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J Bone Miner Res., 2008; PMID: 19113912

Serum Estradiol is Associated with Volumetric Bone Mineral Density and Modulates the Impact of Physical Activity on Bone Size at the Age of Peak Bone Mass; a Study in Healthy Male Siblings

Lapauw B, Taes Y, Bogaert V, Vanbillemont G, Goemaere S, Zmierczak H, De Bacquer D, Kaufman J

Abstract

Abstract Introduction: This study investigates determinants of peak bone mass (PBM) in healthy men, focusing on effects and interactions of parameters reflecting mechanical loading and sex steroids. Methods: Healthy male siblings (n = 677; 25-45 yr) were recruited in a cross-sectional, population-based study. Physical activity score was assessed by a self-reported questionnaire. Cross-sectional muscle area (CSMA) and bone parameters of radius (4 and 66% site) and tibia (66% site) were assessed using peripheral quantitative computed tomography (pQCT). Peak torque of biceps and quadriceps muscles was assessed by isokinetic dynamometry. Serum testosterone (T) and estradiol (E(2)) levels were measured using immunoassays; free hormone fractions were calculated. Relations between indices of bone strength, CSMA, muscle strength, and sex steroids were investigated using linear mixed-effects modeling. Results: Physical activity, CSMA and muscle strength were positively associated with indices of bone strength, except for volumetric bone mineral density (vBMD). After controlling for age, weight and height, free E(2) levels were positively associated with trabecular and cortical vBMD and negatively with endosteal circumference at the radius, and positively with cortical vBMD at the tibia. In addition, positive interactions between physical activity and serum E(2) concentrations were observed for bone size at the tibia. No associations between free T levels and pQCT bone parameters were found. Conclusions: In this population of healthy men at the age of PBM, parameters reflecting mechanical loading are confirmed as important determinants of bone size. E(2), but not T, levels are positively associated with vBMD and modulate the impact of physical activity on bone size at the tibia.

Produktgruppen: pQCT Knochendichte & -geometrie
Themen: Klinische Studien, Klinische Anwendung, Diagnostik mit Leonardo & pQCT
Doc-ID: 1724, 17.02.2009