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Scientific publications for the application area muscle and bone

Here you will find all scientific publications, listed by date of last update. This category currently includes 137 entries.

Literature (137)

Scientific Publications

Gait speed and survival in older adults.

CONTEXT: Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival. Physical performance measures, such as gait speed, mi weiter...

Author: Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, Brach J, Chandler J, Cawthon P, Connor EB, Nevitt M, Visser M, Kritchevsky S, Badinelli S, Harris T, Newman AB, Cauley J, Ferrucci L, Guralnik J
Source: JAMA, 2011; 305(1): 50-8, PMID: 21205966
Keywords: Gait Speed
Doc-ID: 4364,
More information: Original Article

Scientific Publications

The effects of whole body vibration on mobility and balance in children with cerebral palsy: a systematic review with meta-analysis.

OBJECTIVE: We performed a meta-analysis to evaluate the effects of whole-body vibration on physiologic and functional measurements in children with cerebral palsy. DESIGN AND METHODS: We searched MEDLINE, Cochr weiter...

Author: Saquetto M, Carvalho V, Silva C, Conceicao C, Gomes-Neto M
Source: J Musculoskelet Neuronal Interact, 2015; 15(2): 137-44, PMID: 26032205
Keywords: Cerebral Palsy, Exercise, Whole-body Vibration, Mobility
Doc-ID: 3884,

Scientific Publications

Minimal intensity physical activity (standing and walking) of longer duration improves insulin action and plasma lipids more than shorter periods of moderate to vigorous exercise (cycling) in sedentary subjects when energy expenditure is comparable.

BACKGROUND: Epidemiological studies suggest that excessive sitting time is associated with increased health risk, independent of the performance of exercise. We hypothesized that a daily bout of exercise cannot weiter...

Author: Duvivier BM, Schaper NC, Bremers MA, van Crombrugge G, Menheere PP, Kars M, Savelberg HH
Source: PLoS One, 2013; 8(2): e55542, PMID: 23418444
Keywords: often standing and walking during working day much better than intensive workout after long sitting
Doc-ID: 3874,
More information: Original Article

Scientific Publications

Whole body vibration training in patients with COPD: A systematic review.

In recent years, several studies have shown that whole body vibration training (WBVT) may be a beneficial training mode in a variety of chronic diseases and conditions such as osteoporosis, fibromyalgia, multip weiter...

Author: Gloeckl R, Heinzelmann I, Kenn K
Source: Chron Respir Dis, 2015; (): , PMID: 25904085
Doc-ID: 3865,

Scientific Publications

Whole body vibration in sport: a critical review.

Whole body vibration training is a recent area of study in athletic conditioning, health and rehabilitation. This paper provides a review of the effectiveness of this type of training in sport. A search was con weiter...

Author: Costantino C, Gimigliano R, Olvirri S, Gimigliano F
Source: J Sports Med Phys Fitness, 2014; 54(6): 757-64, PMID: 24998609
Doc-ID: 3548,

Scientific Publications

Untersuchungen zur Optimierung des körperlichen Trainings bei Frauen mit postmenopausal verminderter Knochendichte

Hintergrund: Der Erhalt von neuromuskularen Funktionen und einer tragfahigen Knochenmasse bei alteren Menschen wird immer wichtiger, besonders bei alteren Frauen mit verminderter Knochendichte, die zu Sturzen weiter...

Author: N Stolzenberg
Source: Thesis, 2014;
Doc-ID: 3473,

Scientific Publications

Osteoporosis in Men Chapter 52: Exercise programs for Pateints with osteoporosis

Author: Felsenberg D., Runge M.
Source: Osteoporosis in Men, 2010; 635-652
Doc-ID: 3308,

Scientific Publications

The effects of whole-body vibration on muscle strength and power: a meta-analysis.

Exercise with whole-body vibration (WBV) is becoming popular as an alternative to conventional training or as supplementary training. However, despite increasing research efforts in this field, additive effects weiter...

Author: Osawa Y, Oguma Y, Ishii N
Source: J Musculoskelet Neuronal Interact, 2013; 13(3): 342-52, PMID: 23989260
Doc-ID: 3306,
More information: Original Article

Scientific Publications

Hypertrophy in the cervical muscles and thoracic discs in bed-rest?

The impact of prolonged bed-rest on the cervical and upper thoracic spine is unknown. In the 2nd Berlin BedRest Study (BBR2-2), 24 male subjects underwent 60d bed-rest and performed either no exercise, resistiv weiter...

Author: Belavy DL, Miokovic T, Armbrecht G, Felsenberg D
Source: J Appl Physiol, 2013; 115(5): 586-96, PMID: 23813530
Keywords: morphology; uncovertebral joint; magnetic resonance imaging; space- flight; microgravity
Doc-ID: 3237,

Scientific Publications

Changes in body composition in triathletes during an Ironman race.

PURPOSE: Triathletes lose body mass during an Ironman triathlon. However, the associated body composition changes remain enigmatic. Thus, the purpose of this study was to investigate Ironman-induced changes in weiter...

Author: Mueller SM, Anliker E, Knechtle P, Knechtle B, Toigo M
Source: Eur J Appl Physiol, 2013; 113: 2343–2352, PMID: 23748466
Keywords: Dual-energy X-ray absorptiometry (DXA)  Peripheral quantitative computed tomography (pQCT)  Glycogen  Dehydration
Doc-ID: 3247,

Scientific Publications

Vascular adaptations induced by 6 weeks WBV resistance exercise training.

BACKGROUND: The impact of whole-body vibration (WBV) upon the cardiovascular system is receiving increasing attention. Despite numerous studies addressing the acute cardiovascular effects of WBV training, very weiter...

Author: Weber T, Beijer A, Rosenberger A, Mulder E, Yang P, Schonau E, Bloch W, Rittweger J
Source: Clin Physiol Funct Imaging, 2013; 33(2): 92-100, PMID: 23383686
Keywords: arterial function; arterial structure; flow-mediated shear stress; gravitational-induced shear stress; resistive vibration exercise
Doc-ID: 3133,

Scientific Publications

Reliability of ground reaction forces during a vertical jump: implications for functional strength assessment.

OBJECTIVE: To determine the reliability of ground reaction force during a vertical jump. DESIGN AND SETTING: Two test sessions 48 hours apart in which subjects performed five maximal vertical jumps with their r weiter...

Author: Cordova ML, Armstrong CW
Source: J Athl Train, 2010; 31(4): 342-5, PMID: 16558421
Doc-ID: 2969,
More information: Original Article

Scientific Publications

The dynamics of bone structure development during pubertal growth.

The pubertal growth spurt is a time of rapid changes in bone length, mass and structure, followed by the cessation of longitudinal growth. The two best studied anatomical areas in this respect are the metaphyse weiter...

Author: Rauch F
Source: J Musculoskelet Neuronal Interact, 2012; 12(1): 1-6, PMID: 22373945
Doc-ID: 2904,
More information: Original Article

Scientific Publications

Gesundheit im Unternehmen managen und fördern: Vibrationstraining als effektive Maßnahme für Mitarbeiter

Das vorliegende Buch bietet einen umfassenden Überblick zum Thema Gesundheit, Gesundheitsmanagement und Gesundheitsförderung in Unternehmen. Aufgrund der steigenden Altersstruktur der Erwerbspersonen nehmen a weiter...

Author: Seitz D.
Source: 3639384326, 2011;
Keywords: Betriebliche Gesundheitsförderung
Doc-ID: 2779,

Scientific Publications

Why bones bend but don"t break.

The musculoskeletal system is adept at dissipating potentially damaging energy that could accelerate fracture consequent to multiple loading cycles. Microstructural damage reduces bone"s residual properties, bu weiter...

Author: Burr DB
Source: J Musculoskelet Neuronal Interact, 2011; 11(4): 270-85, PMID: 22130136
Doc-ID: 2776,
More information: Original Article

Scientific Publications


The purpose of this study was to investigate the effect of Juvenile Idiopathic Arthritis (JIA) on lower limb muscle activity during a countermovement jump (CMJ). Two groups of patient data were collected; 6 pat weiter...

Author: Dwyer KD; Kennedy MJ; Lamontagne M; Roth J
Source: Portuguese Journal of Sport Sciences, ISBS 2011, 2011; 11(2): 721-3
Doc-ID: 2754,
More information: Original Article

Scientific Publications

Vibration exercise: the potential benefits

The aim of this review was to examine the physiological effects of vibration exercise (VbX), including the cardiovascular indices and to elucidate its potential use for those with compromised health. VbX has lo weiter...

Author: Cochrane DJ
Source: Int J Sports Med, 2011; 32(2): 75-99, PMID: 21165804
Doc-ID: 2686,

Scientific Publications

What do we currently know from in vivo bone strain measurements in humans

Bone strains are the most important factors for osteogenic adaptive responses. During the past decades, scientists have been trying to describe the relationship between bone strain and bone osteogenic responses weiter...

Author: Yang PF, Brüggemann GP, Rittweger J
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 8-20, PMID: 21364270
Doc-ID: 2584,
More information: Original Article

Scientific Publications

Effects of oxidation on the power of chemically skinned rat soleus fibres

Oxidation alters calcium sensitivity, and decreases maximum isometric force (Po) and shortening velocity (Vmax) of single muscle fibres. To examine the effect of oxidation on the curvature of the force-velocity weiter...

Author: Gilliver SF, Jones DA, Rittweger J, Degens H
Source: J Musculoskelet Neuronal Interact., 2010; 10(4): 267-73, PMID: 21116063
Doc-ID: 2485,
More information: Original Article

Scientific Publications

Determinants of peak muscle power: effects of age and physical conditioning

The relationships between absolute peak muscle power (Wpeak), muscle cross sectional area (CSAtot, i.e. the sum of both thigh and calf CSA) and muscle high energy phosphate concentration (adenosine 5"-triphosph weiter...

Author: Ferretti G, Narici MV, Binzoni T, Gariod L, Le Bas JF, Reutenauer H, Cerretelli P
Source: Eur J Appl Physiol Occup Physiol., 1994; 68(2): 111-5, PMID: 8194538
Doc-ID: 2462,

Scientific Publications

Differential effects of countermovement magnitude and volitional effort on vertical jumping

The importance of vertical jumping in sport and rehabilitative medicine is widely recognized. Despite the ample use of jump tests to assess neuromuscular function, the differential effects of muscular activatio weiter...

Author: Salles AS, Baltzopoulos V, Rittweger J
Source: Eur J Appl Physiol., 2010; 111(3: 441-8, PMID: 20882293
Keywords: Mechanography – Electromyography – Motor control – Jump strategy – Neuromuscular testing
Doc-ID: 2418,

Scientific Publications

Reporting whole-body vibration intervention studies: Recommendations of the International Society of Musculoskeletal and Neuronal Interactions

Whole-body vibration (WBV) is receiving increasing interest as a therapeutic modality to improve neuromuscular performance or to increase bone mass or density. In order to help improve the quality of reports ab weiter...

Author: Rauch F, Sievanen H, Boonen S, Cardinale M, Degens H, Felsenberg D, Roth J, Schoenau E, Verschueren S, Rittweger J
Source: J Musculoskelet Neuronal Interact., 2010; 10(3): 193-8, PMID: 20811143
Doc-ID: 2392,
More information: Original Article

Scientific Publications

Reliability of measures obtained during single and repeated countermovement jumps

PURPOSE: To establish the reliability of various measures obtained during single and repeated countermovement jump (CMJ) performance in an elite athlete population. METHODS: Two studies, each involving 15 elite weiter...

Author: Cormack SJ, Newton RU, McGuigan MR, Doyle TL
Source: Int J Sports Physiol Perform., 2008; 3(2): 131-44, PMID: 19208922
Doc-ID: 2121,
More information: Original Article

Scientific Publications

Intersession Reliability of Vertical Jump Height

Introduction: The usefulness of measurements in research depends on the extent to which the researcher can rely on data as accurate and meaningful indicators of a behavior. In short, the measurements have to weiter...

Source: 14th annual Congress ECSS 2009, Oslo, Book of Abstracts, 2009;
Doc-ID: 2120,

Scientific Publications

Changes in muscle mass and strength after menopause

Menopause is associated with a natural decline in estrogen, that increases visceral fat mass, decreases bone mass density, muscle mass, and strength. This review will examine the role of menopause transition an weiter...

Author: Maltais ML, Desroches J, Dionne IJ
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 186-97, PMID: 19949277
Doc-ID: 2108,
More information: Original Article

Scientific Publications

Perspectives: some roles of mechanical usage, muscle strength, and the mechanostat in skeletal physiology, disease, and research

Author: Frost HM, Ferretti JL, Jee WS
Source: Calcif Tissue Int., 1998; 62(1): 1-7, PMID: 9405724
Doc-ID: 2079,

Scientific Publications

Skeletal adaptations during growth

NASA: The authors examine the role of mechanical usage in skeletal development. Principle mechanisms of bone physiology include longitudinal bone growth; modeling drifts; micromodeling; remodeling by the basic weiter...

Author: Jee WS, Frost HM
Source: Triangle., 1992; 31(2/3): 77-88, PMID: 11539347
Doc-ID: 2078,

Scientific Publications

The role of changes in mechanical usage set points in the pathogenesis of osteoporosis

Mechanical usage (MU) effects on modeling drifts and BMU-based remodeling affect bone mass in defined ways. Decreased MU stops additions of bone by modeling and increases removal of bone next to marrow by remod weiter...

Author: Frost HM
Source: J Bone Miner Res., 1992; 7(3): 253-61, PMID: 1585826
Doc-ID: 2077,

Scientific Publications

Mechanical efficiency during repetitive vertical jumping

The purpose of this study was to compare mechanical efficiency between repeated static jumps (SJ), countermovement jumps (CMJ), drop jumps from 75% of maximum CMJ jump height (75DJ) and drop jumps from 125% of weiter...

Author: McCaulley GO, Cormie P, Cavill MJ, Nuzzo JL, Urbiztondo ZG, McBride JM
Source: Eur J Appl Physiol., 2007; 101(1): 115-23, PMID: 17530275
Doc-ID: 2055,

Scientific Publications

Direct corticospinal pathways contribute to neuromuscular control of perturbed stance

The antigravity soleus muscle (Sol) is crucial for compensation of stance perturbation. A corticospinal contribution to the compensatory response of the Sol is under debate. The present study assessed spinal, c weiter...

Author: Taube W, Schubert M, Gruber M, Beck S, Faist M, Gollhofer A
Source: J Appl Physiol., 2006; 101(2): 420-9, PMID: 16601305
Doc-ID: 1999,
More information: Original Article

Scientific Publications

Isometric contraction of the abductor digiti minimi muscle in man

Isometric contraction of the abductor digiti minimi muscle (ADM) has been studied in six normal subjects. Twitch contraction times of ADM ranged from 60 to 68 ms and twitch torque ranged from 2·33 to 6·24 x 1 weiter...

Author: Burke D, Skuse NF, Lethlean AK
Source: J Neurol Neurosurg Psychiatry., 1974; 37(7): 825-34, PMID: 4852602
Doc-ID: 1996,
More information: Original Article

Scientific Publications

Contraction times and fibre types in intact human muscle

Twitches were recorded in situ in muscles of normal humans by small transducers connected to a needle in the tendon. The twitches were elicited by stimuli in the endplate zone, the force of the smallest twitche weiter...

Author: Buchthal F, Schmalbruch H.
Source: Acta Physiol Scand, 1970; 79(4): 435-52, PMID: 5472111
Keywords: Contraction Time, muscle function
Doc-ID: 1995,

Scientific Publications

Enhanced Skeletal Parameters in Gymnasts Are Not Attributable to Self-Selection Bias

Author: Dowthwaite J, Gero N, Rosenbaum P, Scerpella T
Source: ASBMR, 2009;
Doc-ID: 1956,

Scientific Publications

Vibration therapy

Whole-body vibration training is a method for muscle strengthening that is increasingly used in a variety of clinical situations. Key descriptors of vibration devices include the frequency, the amplitude, and t weiter...

Author: Rauch F
Source: Dev Med Child Neurol., 2009; 51 Suppl 4: 166-8, PMID: 19740225
Doc-ID: 1951,

Scientific Publications

Biomechanical loading of Achilles tendon during normal locomotion

Direct in vivo Achilles tendon force measurements open up new possibilities for understanding the loading of the Achilles tendon during natural locomotion. This article describes how these human experiments can weiter...

Author: Komi PV, Fukashiro S, Järvinen M
Source: Clin Sports Med., 1992; 11(3): 521-31, PMID: 1638639
Doc-ID: 1879,

Scientific Publications

In vivo Achilles tendon loading during jumping in humans

Elastic behaviour of the human tendomuscular system during jumping was investigated by determination of the in vivo Achilles tendon force. A buckle-type transducer was implanted under local anaesthesia around t weiter...

Author: Fukashiro S, Komi PV, Järvinen M, Miyashita M
Source: Eur J Appl Physiol Occup Physiol., 1995; 71(5): 453-8, PMID: 8565978
Doc-ID: 1877,

Scientific Publications

In vivo measurement-based estimations of the human Achilles tendon moment arm

The aim of the present study was to estimate and compare in vivo measurement-based Achilles tendon moment arm lengths at rest and during isometric plantarflexion maximum voluntary contraction (MVC) using the ce weiter...

Author: Maganaris CN, Baltzopoulos V, Sargeant AJ
Source: Eur J Appl Physiol., 2000; 83(4 -5): 363-9, PMID: 11138576
Keywords: maximum internal forces on tibia
Doc-ID: 1876,

Scientific Publications

Local body composition is associated with gender differences of bone development at the forearm in puberty

BACKGROUND/AIMS: The present analyses intend to clarify if gender and puberty modify the relationship between bone development (modeling and remodeling) and fat mass at the forearm. METHODS: Data were collected weiter...

Author: Fricke O, Sumnik Z, Tutlewski B, Stabrey A, Remer T, Schoenau E
Source: Horm Res., 2008; 70(2): 105-11, PMID: 18547958
Doc-ID: 1857,

Scientific Publications

Mechanical influences on bone development in children

This review focuses on methodological concepts in the evaluation of skeletal muscle function and on adaptation. It is now thought that the critical property of bone is strength rather than weight, and that cont weiter...

Author: Schoenau E, Fricke O
Source: Eur J Endocrinol., 2008; 159 Suppl 1: S27-31, PMID: 18787052
Doc-ID: 1856,
More information: Original Article

Scientific Publications

The "functional muscle-cartilage unit": a reasonable approach to describe a putative relationship between muscle force and longitudinal growth at the forearm in children and adolescents

BACKGROUND: Several reports give evidence that the perichondral ossificiation of bone tubes (modeling) strongly depends on muscular forces in children and adolescents. The present analyses intend to investigate weiter...

Author: Fricke O, Beccard R, Semler O, Land C, Stabrey A, Tutlewski B, Remer T, Schoenau E
Source: Horm Res., 2008; 70(5): 285-93, PMID: 18824867
Doc-ID: 1855,

Scientific Publications

What is new in neuro-musculoskeletal interactions: Bye-bye, density?

Author: Rauch F
Source: J Musculoskelet Neuronal Interact., 2003; 3(3): 258-60, PMID: 15758350
Doc-ID: 1851,
More information: Original Article

Scientific Publications

What is new in neuro-musculoskeletal interactions: On soups, hips and humeri

Author: Rittweger J, Rauch F
Source: J Musculoskelet Neuronal Interact., 2003; 3(1): 101-4, PMID: 15758372
Doc-ID: 1850,
More information: Original Article

Scientific Publications

What is new in neuro-musculoskeletal interactions: Strain on Bones

Author: Rauch F, Rittweger J
Source: J Musculoskelet Neuronal Interact., 2002; 2(5): 489-92, PMID: 15758418
Doc-ID: 1849,
More information: Original Article

Scientific Publications

What is new in neuro-musculoskeletal interactions: Research with impact

Author: Rauch F, Rittweger J
Source: J Musculoskelet Neuronal Interact., 2001; 1(4): 393-8, PMID: 15758490
Doc-ID: 1848,
More information: Original Article

Scientific Publications

What is new in neuro-musculoskeletal interactions: mechanotransduction, microdamage and repair

Author: Rittweger J
Source: J Musculoskelet Neuronal Interact., 2007; 7(2): 191-3, PMID: 17627090
Doc-ID: 1847,
More information: Original Article

Scientific Publications

Revival of bone strength: the bottom line

Author: Järvinen TL, Sievänen H, Jokihaara J, Einhorn TA
Source: J Bone Miner Res., 2005; 20(5): 717-20, PMID: 15824843
Doc-ID: 1730,

Scientific Publications

Updates on improvement of human athletic performance: focus on world records in athletics

INTRODUCTION: Progression of world records (WRs) in athletics is a reliable mean to assess the potentiality of the human body, which also reflects how society has evolved over time and will continue to evolve. weiter...

Author: Lippi G, Banfi G, Favaloro EJ, Rittweger J, Maffulli N
Source: Br Med Bull., 2008; 87: 7-15, PMID: 18723588
Doc-ID: 1779,

Scientific Publications

Ten years muscle-bone hypothesis: What have we learned so far? -Almost a Festschrift-

The importance of mechanical stimuli for bone is widely appreciated. Mechanostat theory proposes a negative feedback system to explain the adaptation of bone by homeostatic control of peak strains. However, no weiter...

Author: Rittweger J
Source: J Musculoskelet Neuronal Interact., 2008; 8(2): 174-8, PMID: 18622086
Doc-ID: 1650,
More information: Original Article

Scientific Publications

Drop jumping. II. The influence of dropping height on the biomechanics of drop jumping

In the literature, athletes preparing for explosive activities are recommended to include drop jumping in their training programs. For the execution of drop jumps, different techniques and different dropping he weiter...

Author: Bobbert MF, Huijing PA, van Ingen Schenau GJ
Source: Med Sci Sports Exerc., 1987; 19(4): 339-46, PMID: 3657482
Doc-ID: 1648,

Scientific Publications

Principles in bone physiology

The view that nonmechanical agents dominate control of osteoblasts and osteoclasts and thus postnatal changes in bone strength and mass (agent --> effector cells --> disease) is obsolete. Nonmechanical agents i weiter...

Author: Jee WS
Source: J Musculoskelet Neuronal Interact., 2000; 1(1): 11-3, PMID: 15758518
Doc-ID: 1644,
More information: Original Article

Scientific Publications

The benefit of combining non-mechanical agents with mechanical loading: a perspective based on the Utah Paradigm of Skeletal Physiology

The Utah Paradigm of Skeletal Physiology with its key component, the mechanostat hypothesis, suggest plausible explanations of some of the tissue-level changes occurring from combining selected non-mechanical a weiter...

Author: Jee WS, Tian XY
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 110-8, PMID: 15951626
Doc-ID: 1641,
More information: Original Article

Scientific Publications

Musculoskeletal responses of 2-year-old Thoroughbred horses to early training. Conclusions

This paper summarises and presents in context the main findings of an extensive series of studies of early training lasting 13 weeks in which the tissue responses of 2-year-old Thoroughbred horses were assessed weiter...

Author: Firth EC, Rogers CW
Source: N Z Vet J., 2005; 53(6): 377-83, PMID: 16317437
Doc-ID: 1620,

Scientific Publications

From Wolff"s law to the Utah paradigm: insights about bone physiology and its clinical applications

Efforts to understand our anatomy and physiology can involve four often overlapping phases. We study what occurs, then how, then ask why, and then seek clinical applications. In that regard, in 1960 views, bone weiter...

Author: Frost HM
Source: Anat Rec., 2001; 262(4): 398-419, PMID: 11275971
Doc-ID: 1609,

Scientific Publications

Coming changes in accepted wisdom about "osteoporosis"

Here a voice from the past suggests 28 changes that will affect how people study, manage, classify and think about "osteoporoses" today. Those changes depend mainly on two things: (i) "Connecting the dots" betw weiter...

Author: Frost HM
Source: J Musculoskelet Neuronal Interact., 2004; 4(1): 78-85, PMID: 15615080
Doc-ID: 1608,
More information: Original Article

Scientific Publications

New targets for fascial, ligament and tendon research: a perspective from the Utah paradigm of skeletal physiology

Here an octogenarian voice from the past argues that the physiology of fascia, ligaments and tendons has strong and useful analogs in some general features of bone physiology, including the latter"s tissue-leve weiter...

Author: Frost HM
Source: J Musculoskelet Neuronal Interact., 2003; 3(3): 201-9, PMID: 15758342
Doc-ID: 1607,
More information: Original Article

Scientific Publications

Perspective: genetic and hormonal roles in bone disorders: insights of an updated bone physiology

In 1997 Professor J. Gorski suggested endocrinology needed new paradigms (Endocrine News 1997; 22:4,12). "Connecting the dots" between diverse facts and ideas drawn from many lines of inquiry, plus accumulating weiter...

Author: Frost HM
Source: J Musculoskelet Neuronal Interact., 2003; 3(2): 118-35, PMID: 15758352
Doc-ID: 1606,
More information: Original Article

Scientific Publications

On the strength-safety factor (SSF) for load-bearing skeletal organs

The strength of healthy postnatal mammalian load-bearing bones, growth plates, joints, fascia, ligaments and tendons exceeds the minimum strength needed to keep voluntary mechanical usage from breaking or ruptu weiter...

Author: Frost HM
Source: J Musculoskelet Neuronal Interact., 2003; 3(2): 136-40, PMID: 15758353
Doc-ID: 1605,
More information: Original Article

Scientific Publications

On the pathogenesis of osteogenesis imperfecta: some insights of the Utah paradigm of skeletal physiology

The pathogenesis of osteogenesis imperfecta (OI) baffled physiologists and physicians for over a century. Most past efforts to explain it depended heavily on cell and molecular biology and on changes in the mat weiter...

Author: Frost HM
Source: J Musculoskelet Neuronal Interact., 2003; 3(1): 1-7, PMID: 15758360
Doc-ID: 1604,
More information: Original Article

Scientific Publications

Why should many skeletal scientists and clinicians learn the Utah paradigm of skeletal physiology

Adding later facts and ideas to a universally accepted "1960 paradigm" of skeletal physiology led to the still-evolving "Utah paradigm". The ASBMR"s William Neuman award in 2001 to one of the latter paradigm"s weiter...

Author: Frost HM
Source: J Musculoskelet Neuronal Interact., 2001; 2(2): 121-30, PMID: 15758459
Doc-ID: 1603,
More information: Original Article

Scientific Publications

The Utah paradigm on animal models of skeletal disorders: quo vadis

Skeletal disorders that need effective studies in suitable animal models include "osteoporosis", arthroses and hard and soft tissue healing. For people doing or analyzing such studies this article provides a br weiter...

Author: Frost HM
Source: J Musculoskelet Neuronal Interact., 2001; 1(3): 185-91, PMID: 15758492
Doc-ID: 1602,
More information: Original Article

Scientific Publications

Why the ISMNI and the Utah paradigm? Their role in skeletal and extraskeletal disorders

Besides bringing problems, aging can let the mind"s eye see more clearly than before, and it can let us express ourselves better. As age, experience and common sense examine today"s skeletal medicine and surger weiter...

Author: Frost HM
Source: J Musculoskelet Neuronal Interact., 2000; 1(1): 5-9, PMID: 15758517
Doc-ID: 1601,
More information: Original Article

Scientific Publications

The Utah paradigm of skeletal physiology: an overview of its insights for bone, cartilage and collagenous tissue organs

In a 1960 paradigm of skeletal physiology, effector cells (chondroblasts, fibroblasts, osteoblasts, osteoclasts, etc.) regulated by nonmechanical agents wholly determined the architecture, strength, and health weiter...

Author: Frost HM
Source: J Bone Miner Metab., 2000; 18(6): 305-16, PMID: 11052462
Doc-ID: 1599,

Scientific Publications

Variation in the density of the femoral diaphysis with age

1. A detailed study of density variations with age in cortical bone samples from different areas of the femoral diaphysis has been carried out. 2. Bone of relatively high density and, conversely, of low densit weiter...

Author: Atkinson PJ, Weatherell JA
Source: J Bone Joint Surg Br., 1967; 49(4): 781-8, PMID: 6073195
Doc-ID: 1590,

Scientific Publications

Bone growth in length and width: the Yin and Yang of bone stability

Bone growth in length is primarily achieved through the action of chondrocytes in the proliferative and hypertrophic zones of the growth plate. Longitudinal growth is controlled by systemic, local paracrine and weiter...

Author: Rauch F
Source: J Musculoskelet Neuronal Interact., 2005; 5(3): 194-201, PMID: 16172510
Doc-ID: 1586,
More information: Original Article

Scientific Publications

The Management of Postmenopausal Osteoporosis: A Position Paper of the World Health Origination Collaborating Center on Public Health Aspects of Rheumatic Diseases

Author: P.D. Delmas, N. Khaltaev, M. Arriagada, M.L. Brandi, J. Cannata, E. Lau, R. Lederman, R. Lorenc, H. Minne, J. Morales-Torres, H. Morii, P. Sambrook, T. Torralba, J. Zanchetta, J.Y. Reginster
Source: Musculoskelet Neuronal Interact, 2005; 5(2): 105-109
Doc-ID: 1585,
More information: Original Article

Scientific Publications

Energy metabolism in human calf muscle performing isometric plantar flexion superimposed by 20-Hz vibration

Vibration training is commonly expected to induce an active muscle contraction via a complex reflex mechanism. In calf muscles of 20 untrained subjects, the additional energy consumption in response to vibratio weiter...

Author: Zange J, Haller T, Müller K, Liphardt AM, Mester J
Source: Eur J Appl Physiol., 2008; PMID: 18953563
Doc-ID: 1576,

Scientific Publications

Bone quality: an empty term

Author: Sievänen H, Kannus P, Järvinen TL
Source: PLoS Med., 2007; 4(3): e27, PMID: 17341126
Doc-ID: 1517,
More information: Original Article

Scientific Publications

Brief communication: Two and three-dimensional analysis of bone mass and microstructure in a bog body from the Iron Age

Human remains from peat bogs, called "bog bodies," have yielded valuable insights into human history because of their excellent preservation of soft tissue. On the other hand, the acidic environment of the peat weiter...

Author: Schilling AF, Kummer T, Marshall RP, Bauerochse A, Jopp E, Pueschel K, Amling M
Source: Am J Phys Anthropol., 2008; 135(4): 479-83, PMID: 18000892
Doc-ID: 1502,

Scientific Publications

Relative strength of the tibia and fibula and locomotor behavior in hominoids

The fibula has rarely been considered in comparative morphological studies, probably due to its relatively minor role in carrying mechanical loads. However, some differences in morphology (and inferred function weiter...

Author: Marchi D
Source: J Hum Evol., 2007; 53(6): 647-55, PMID: 17675139
Doc-ID: 1331,

Scientific Publications

Risk factors for falls among elderly persons living in the community

To study risk factors for falling, we conducted a one-year prospective investigation, using a sample of 336 persons at least 75 years of age who were living in the community. All subjects underwent detailed cli weiter...

Author: Tinetti ME, Speechley M, Ginter SF
Source: N Engl J Med., 1988; 319(26): 1701-7, PMID: 3205267
Doc-ID: 1288,

Scientific Publications

Bone mineral density in chimpanzees, humans, and Japanese macaques

We performed a comparative study of bone mechanical properties in the radii of chimpanzees (Pan troglodytes), humans (Homo sapiens), and Japanese macaques (Macaca fuscata) using peripheral quantitative computed weiter...

Author: Kikuchi Y, Udono T, Hamada Y
Source: Primates., 2003; 44(2): 151-5, PMID: 12687479
Doc-ID: 1257,

Scientific Publications

Measurement of bone density and bone strength with pQCT

Author: J. Willnecker
Source: Novel approaches towards primate toxicology, 2006; 13 - 19
Doc-ID: 1213,

Scientific Publications

The peak bone mass concept: is it still relevant

The peak bone mass concept implies that optimal skeletal development during childhood and adolescence will prevent fractures in late adulthood. This concept is based on the observation that areal bone density i weiter...

Author: Schönau E
Source: Pediatr Nephrol., 2004; 19(8): 825-31, PMID: 15197638
Doc-ID: 1138,

Scientific Publications

From bone biology to bone analysis

Bone development is one of the key processes characterizing childhood and adolescence. Understanding this process is not only important for physicians treating pediatric bone disorders, but also for clinicians weiter...

Author: Schoenau E, Saggese G, Peter F, Baroncelli GI, Shaw NJ, Crabtree NJ, Zadik Z, Neu CM, Noordam C, Radetti G, Hochberg Z
Source: Horm Res., 2004; 61(6): 257-69, PMID: 14963367
Doc-ID: 1136,

Scientific Publications

Noninvasive Analysis of Bone Mass, Structure, and Strength

Author: JL Ferretti, GR Cointry, RF Capozza
Source: Orthopaedic Issues in Osteoporosis CRC Press, 2002; 145 - 167
Doc-ID: 1081,

Scientific Publications

Osteopenias and Osteoporoses - Muscle Bone Interactions, Absorptiometry, Safety Factors, and Fracture Risk

Author: JL Ferretti, HM Frost
Source: CRC Press 2002 (202 - 217) Orthopaedic Issues in Osteoporosis CRC Press, 2002; 202 - 217
Doc-ID: 1083,

Scientific Publications

Quantitative Bestimmung der Knochenmasse: heutiger Stand und Fallstricke der Methoden

Author: P Schneider, C Reiners
Source: Med Welt (1998) 49: 157 - 163, 1998; 49: 157-163
Doc-ID: 1088,

Scientific Publications

Osteoporosis a disease requiring treatment or a physiologic osteopenia state? WHO definition in opposition to Utah Paradigm?

Author: Frost HM, Schneider P, Schneider R
Source: Dtsch Med Wochenschr., 2002; 127(48): 2570-4, PMID: 12457328
Doc-ID: 1091,

Scientific Publications

Peripheral Quantitative Computed Tomography

Author: P Schneider, C Reiners
Source: Bone Densitometry and Osteoporosis Springer, 1998; 349-363
Doc-ID: 1093,

Scientific Publications

Can exercise prevent osteoporosis

Commonly used definitions of osteoporosis rely upon the measurement of bone mass or bone mineral density and regard the difference between osteopenia and osteoporosis as gradual. An alternative definition has b weiter...

Author: Rittweger J
Source: J Musculoskelet Neuronal Interact., 2006; 6(2): 162-6, PMID: 16849827
Doc-ID: 1071,
More information: Original Article

Scientific Publications

New Noninvasive pQCT Devices to Determine Bone Structure

Author: G Tysarczyk-Niemeyer
Source: J Jpn Soc Bone Morphom, 1997; 7: 97-105
Doc-ID: 1000,

Scientific Publications

The "muscle-bone unit" in children and adolescents: a 2000 overview

In former views hormones, calcium, vitamin D and other humoral and nonmechanical agents dominated control of postnatal bone strength (and "mass") in children and adolescents. However later evidence that led to weiter...

Author: Frost HM, Schönau E
Source: J Pediatr Endocrinol Metab., 2000; 13(6): 571-90, PMID: 10905381
Doc-ID: 1027,

Scientific Publications

CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts

Fusion of macrophages is an essential step in the differentiation of osteoclasts, which play a central role in the development and remodeling of bone. Osteoclasts are important mediators of bone loss, which lea weiter...

Author: Cui W, Cuartas E, Ke J, Zhang Q, Einarsson HB, Sedgwick JD, Li J, Vignery A
Source: Proc Natl Acad Sci U S A., 2007; 104(36): 14436-41, PMID: 17726108
Doc-ID: 959,

Scientific Publications

Ability of peripheral QCT at the radius in comparison to DEXA of the spine to diagnose osteoporosis in postmenopausal women

Author: P.Schneider, W. Börner
Source: Osteoporosis, 1990; 59: 921-924
Doc-ID: 974,

Scientific Publications

Stellenwert zweier unterschiedlicher Knochendichtemeßmethoden zur Bestimmung des Mineralgehalts am peripheren und axialen Skelett

(English) Between May 1990 and February 1991 we enrolled 212 patients of 410 referred to our clinic for bone mass evaluation according to different diagnosis or therapeutic procedures. These patients were divi weiter...

Author: P. Schneider, W. Börner, J. Rendl, C. Eilles, K. Schlißke, M. Scheubeck
Source: Z Orthop (1992) 130: 16-21, 1992; 130: 16-21
Doc-ID: 975,

Scientific Publications

pQCT as an Investigation Tool

Source: Acta Orthop Scand, 2002; Suppl 303) 43:: 44 - 52
Doc-ID: 864,
More information: Original Article

Scientific Publications

Genetics of osteoporosis

Osteoporosis is a common multifactorial disorder of reduced bone mass. The disorder in its most common form is generalized, affecting the elderly, both sexes, and all racial groups. Multiple environmental facto weiter...

Author: Peacock M, Turner CH, Econs MJ, Foroud T
Source: Endocr Rev., 2002; 23(3): 303-26, PMID: 12050122
Doc-ID: 724,

Scientific Publications

Effect of Exercise on Bone Mass and Structure with Special Reference to Maintenance of the Exerciseinduced Bone Gain

The primary findings and conclusions of the present series of studies can be summarised as follows: I Studies I and II demonstrated that long-term racquet sports training had increased bone mineral mass and weiter...

Author: Kontulainen S
Source: Disseration, 2002;
Keywords: Bone Training
Doc-ID: 671,
More information: Original Article

Scientific Publications

A 2003 update of bone physiology and Wolff"s Law for clinicians

By 1892, Julius Wolff and others realized that mechanical loads can affect bone architecture in living beings, but the mechanisms responsible for this effect were unknown, and it had no known clinical applicati weiter...

Author: Frost HM
Source: Angle Orthod., 2004; 74(1): 3-15, PMID: 15038485
Doc-ID: 587,
More information: Original Article

Scientific Publications

Vibration exercise makes your muscles and bones stronger: fact or fiction

Vibration transmitted to the whole body or part of it has been extensively studied in relation to the risks to the health and safety of workers. These studies have highlighted the particular danger of lower-bac weiter...

Author: Cardinale M, Rittweger J
Source: J Br Menopause Soc., 2006; 12(1): 12-8, PMID: 16513017
Doc-ID: 572,

Scientific Publications

Differential shock transmission response of the human body to impact severity and lower limb posture

The shocks imparted to the foot during locomotion may lead to joint-degenerative diseases and jeopardize the visual-vestibular functions. The body relies upon several mechanisms and structures that have unique weiter...

Author: Lafortune MA, Lake MJ, Hennig EM
Source: J Biomech, 1996; 29(12): 1531-7, PMID: 8945651
Doc-ID: 29,

Scientific Publications

Muscle mechanical advantage of human walking and running: implications for energy cost

Muscular forces generated during locomotion depend on an animal"s speed, gait, and size and underlie the energy demand to power locomotion. Changes in limb posture affect muscle forces by altering the mechanica weiter...

Author: Biewener AA, Farley CT, Roberts TJ, Temaner M
Source: J Appl Physiol., 2004; 97(6): 2266-74, PMID: 15258124
Doc-ID: 100,

Scientific Publications

Minimizing center of mass vertical movement increases metabolic cost in walking

A human walker vaults up and over each stance limb like an inverted pendulum. This similarity suggests that the vertical motion of a walker"s center of mass reduces metabolic cost by providing a mechanism for p weiter...

Author: Ortega JD, Farley CT
Source: J Appl Physiol., 2005; 99(6): 2099-107, PMID: 16051716
Doc-ID: 99,

Scientific Publications

Mechanism of leg stiffness adjustment for hopping on surfaces of different stiffnesses

When humans hop in place or run forward, leg stiffness is increased to offset reductions in surface stiffness, allowing the global kinematics and mechanics to remain the same on all surfaces. The purpose of the weiter...

Author: Farley CT, Houdijk HH, Van Strien C, Louie M
Source: J Appl Physiol., 1998; 85(3): 1044-55, PMID: 9729582
Doc-ID: 98,

Scientific Publications

Mechanics of locomotion in lizards

Lizards bend their trunks laterally with each step of locomotion and, as a result, their locomotion appears to be fundamentally different from mammalian locomotion. The goal of the present study was to determin weiter...

Author: Farley CT, Ko TC
Source: J Exp Biol., 1997; 200(Pt 16): 2177-88, PMID: 9286099
Doc-ID: 97,

Scientific Publications

Maximum speed and mechanical power output in lizards

The goal of the present study was to test the hypothesis that maximum running speed is limited by how much mechanical power the muscular system can produce. To test this hypothesis, two species of lizards, Cole weiter...

Author: Farley CT
Source: J Exp Biol., 1997; 200(Pt 16): 2189-95, PMID: 9286100
Doc-ID: 96,

Scientific Publications

Low cost of locomotion in the banded Gecko: a test of the nocturnality hypothesis

This study tested the hypothesis that there has been an evolutionary increase in locomotor performance capacity at low temperature in nocturnal lizards. Nocturnal lizards are often active at low and suboptimal weiter...

Author: Autumn K, Farley CT, Emshwiller M, Full RJ
Source: Physiol Zool., 1997; 70(6): 660-9, PMID: 9361140
Doc-ID: 95,

Scientific Publications

Locomotion. Just skip it

When four-legged animals want to move quickly they gallop -- a gait that was thought to have no equivalent in humans. But a new paper shows that skipping in humans is biomechanically similar to galloping. In bo weiter...

Author: Farley CT
Source: Nature., 1998; 394(6695): 721-3
Doc-ID: 94,

Scientific Publications

Leg stiffness primarily depends on ankle stiffness during human hopping

When humans hop in place or run forward, they adjust leg stiffness to accommodate changes in stride frequency or surface stiffness. The goal of the present study was to determine the mechanisms by which humans weiter...

Author: Farley CT, Morgenroth DC
Source: J Biomech., 1999; 32(3): 267-73, PMID: 10093026
Doc-ID: 93,

Scientific Publications

Leg stiffness and stride frequency in human running

When humans and other mammals run, the body"s complex system of muscle, tendon and ligament springs behaves like a single linear spring ("leg spring"). A simple spring-mass model, consisting of a single linear weiter...

Author: Farley CT, González O
Source: J Biomech., 1996; 29(2): 181-6, PMID: 8849811
Doc-ID: 92,

Scientific Publications

Individual limb work does not explain the greater metabolic cost of walking in elderly adults

Elderly adults consume more metabolic energy during walking than young adults. Our study tested the hypothesis that elderly adults consume more metabolic energy during walking than young adults because they per weiter...

Author: Ortega JD, Farley CT
Source: J Appl Physiol., 2007; 102(6): 2266-73, PMID: 17363623
Doc-ID: 90,

Scientific Publications

How animals move: an integrative view

Recent advances in integrative studies of locomotion have revealed several general principles. Energy storage and exchange mechanisms discovered in walking and running bipeds apply to multilegged locomotion and weiter...

Author: Dickinson MH, Farley CT, Full RJ, Koehl MA, Kram R, Lehman S
Source: Science., 2000; 288(5463): 100-6, PMID: 10753108
Doc-ID: 85,

Scientific Publications

Interaction of leg stiffness and surfaces stiffness during human hopping

When mammals run, the overall musculoskeletal system behaves as a single linear "leg spring". We used force platform and kinematic measurements to determine whether leg spring stiffness (k(leg)) is adjusted to weiter...

Author: Ferris DP, Farley CT
Source: J Appl Physiol., 1997; 82(1): 15-22; discussion 13, PMID: 9029193
Doc-ID: 91,

Scientific Publications

Independent metabolic costs of supporting body weight and accelerating body mass during walking

The metabolic cost of walking is determined by many mechanical tasks, but the individual contribution of each task remains unclear. We hypothesized that the force generated to support body weight and the work p weiter...

Author: Grabowski A, Farley CT, Kram R
Source: J Appl Physiol., 2005; 98(2): 579-83, PMID: 15649878
Doc-ID: 89,

Scientific Publications

Human hopping on very soft elastic surfaces: implications for muscle pre-stretch and elastic energy storage in locomotion

During hopping in place and running, humans maintain similar center of mass dynamics by precisely adjusting leg mechanics to compensate for moderate changes in surface stiffness. We investigated the limits of t weiter...

Author: Moritz CT, Farley CT
Source: J Exp Biol., 2005; 208(Pt 5): 939-49, PMID: 15755892
Doc-ID: 88,

Scientific Publications

Human hopping on damped surfaces: strategies for adjusting leg mechanics

Fast-moving legged animals bounce along the ground with spring-like legs and agilely traverse variable terrain. Previous research has shown that hopping and running humans maintain the same bouncing movement of weiter...

Author: Moritz CT, Farley CT
Source: Proc Biol Sci., 2003; 270(1525): 1741-6, PMID: 12965003
Doc-ID: 87,

Scientific Publications

Human hoppers compensate for simultaneous changes in surface compression and damping

On a range of elastic and damped surfaces, human hoppers and runners adjust leg mechanics to maintain similar spring-like mechanics of the leg and surface combination. In a previous study of adaptations to damp weiter...

Author: Moritz CT, Farley CT
Source: J Biomech., 2006; 39(6): 1030-8, PMID: 16549093
Doc-ID: 86,

Scientific Publications

Regulation of stiffness by skeletomotor reflexes

Since the early 1950s when Merton introduced his "follow-up serco hypothesis" of movement control, the dominant optinion has held that strech and unloading reflexes function to control the length of a muscle in weiter...

Author: Houk JC
Source: Annu Rev Physiol., 1979; 41: 99-114
Doc-ID: 84,
More information: Original Article

Scientific Publications

Hopping frequency in humans: a test of how springs set stride frequency in bouncing gaits

The storage and recovery of elastic energy in muscle-tendon springs is important in running, hopping, trotting, and galloping. We hypothesized that animals select the stride frequency at which they behave most weiter...

Author: Farley CT, Blickhan R, Saito J, Taylor CR
Source: J Appl Physiol., 1991; 71(6): 2127-32, PMID: 1778902
Doc-ID: 83,

Scientific Publications

Determinants of the center of mass trajectory in human walking and running

Walking is often modeled as an inverted pendulum system in which the center of mass vaults over the rigid stance limb. Running is modeled as a simple spring-mass system in which the center of mass bounces along weiter...

Author: Lee CR, Farley CT
Source: J Exp Biol., 1998; 201(Pt 21): 2935-44, PMID: 9866878
Doc-ID: 82,

Scientific Publications

Energetics of walking and running: insights from simulated reduced-gravity experiments

On Earth, a person uses about one-half as much energy to walk a mile as to run a mile. On another planet with lower gravity, would walking still be more economical than running? When people carry weights while weiter...

Author: Farley CT, McMahon TA
Source: J Appl Physiol., 1992; 73(6): 2709-12, PMID: 1490989
Doc-ID: 81,

Scientific Publications

Energetics and mechanics of human running on surfaces of different stiffnesses

Mammals use the elastic components in their legs (principally tendons, ligaments, and muscles) to run economically, while maintaining consistent support mechanics across various surfaces. To examine how leg sti weiter...

Author: Kerdok AE, Biewener AA, McMahon TA, Weyand PG, Herr HM
Source: J Appl Physiol., 2002; 92(2): 469-78, PMID: 11796653
Doc-ID: 80,

Scientific Publications

Biomechanics of walking and running: center of mass movements to muscle action

Author: Farley CT, Ferris DP
Source: Exerc Sport Sci Rev., 1998; 26: 253-85, PMID: 9696992
Doc-ID: 79,
More information: Original Article

Scientific Publications

Athletic footwear, leg stiffness, and running kinematics

CONTEXT: The leg acts as a linear spring during running and hopping and adapts to the stiffness of the surface, maintaining constant total stiffness of the leg-surface system. Introducing a substance (eg, footw weiter...

Author: Bishop M, Fiolkowski P, Conrad B, Brunt D, Horodyski M
Source: J Athl Train., 2006; 41(4): 387-92, PMID: 17273463
Doc-ID: 77,

Scientific Publications

Biomechanics of quadrupedal walking: how do four-legged animals achieve inverted pendulum-like movements

Walking involves a cyclic exchange of gravitational potential energy and kinetic energy of the center of mass. Our goal was to understand how the limbs of walking quadrupeds coordinate the vertical movements of weiter...

Author: Griffin TM, Main RP, Farley CT
Source: J Exp Biol., 2004; 207(Pt 20): 3545-58, PMID: 15339951
Doc-ID: 78,

Scientific Publications

A mechanical trigger for the trot-gallop transition in horses

It is widely thought that animals switch gaits at speeds that minimize energetic cost. Horses naturally switched from a trot to a gallop at a speed where galloping required more energy than trotting, and thus, weiter...

Author: Farley CT, Taylor CR
Source: Science., 1991; 253(5017): 306-8, PMID: 1857965
Doc-ID: 76,

Scientific Publications

What is new in neuro-musculoskeletal interactions: Neuromuscular Science

Author: Rittweger J, Rauch F
Source: J Musculoskelet Neuronal Interact., 2002; 2(2): 177-80, PMID: 15758468
Keywords: Mechanostat
Doc-ID: 356,
More information: Original Article

Scientific Publications

Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group

BACKGROUND. Many risk factors for hip fractures have been suggested but have not been evaluated in a comprehensive prospective study. METHODS. We assessed potential risk factors, including bone mass, in 9516 wh weiter...

Author: Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM
Source: N Engl J Med., 1995; 332(12): 767-73, PMID: 7862179
Doc-ID: 52,

Scientific Publications

Risk factors for recurrent nonsyncopal falls. A prospective study

Falls are a major threat to the health of older persons. We evaluated potential risk factors for falls in 325 community-dwelling persons aged 60 years or older who had fallen during the previous year, then foll weiter...

Author: Nevitt MC, Cummings SR, Kidd S, Black D
Source: JAMA., 1989; 261(18): 2663-8, PMID: 2709546
Doc-ID: 53,

Scientific Publications

Defining osteopenias and osteoporoses: another view (with insights from a new paradigm)

This article suggests classifying "osteoporoses" by their biomechanical pathogenesis instead of by their severity or their accompanying medical conditions. (A) In a "true osteoporosis," bone fragility would inc weiter...

Author: Frost HM
Source: Bone., 1997; 20(5): 385-91, PMID: 9145234
Keywords: Mechanostat
Doc-ID: 289,

Scientific Publications

Why do marathon runners have less bone than weight lifters? A vital-biomechanical view and explanation

Author: Frost HM
Source: Bone., 1997; 20(3): 183-9, PMID: 9071467
Keywords: Mechanostat
Doc-ID: 288,

Scientific Publications

High-frequency vibration training increases muscle power in postmenopausal women

OBJECTIVE: To test whether training on a high-frequency (28Hz) vibrating platform improves muscle power and bone characteristics in postmenopausal women. DESIGN: Randomized controlled trial with 6-month follow- weiter...

Author: Russo CR, Lauretani F, Bandinelli S, Bartali B, Cavazzini C, Guralnik JM, Ferrucci L
Source: Arch Phys Med Rehabil., 2003; 84(12): 1854-7, PMID: 14669194
Doc-ID: 274,

Scientific Publications

Predictors of falls among elderly people. Results of two population-based studies

A study was performed to identify and rank risk factors for falling among populations of institutionalized (fallers, N = 79, nonfallers, N = 70) and noninstitutionalized (fallers, N = 34, nonfallers, N = 34) el weiter...

Author: Robbins AS, Rubenstein LZ, Josephson KR, Schulman BL, Osterweil D, Fine G
Source: Arch Intern Med., 1989; 149(7): 1628-33, PMID: 2742437
Doc-ID: 55,

Scientific Publications

Die Muskeln als Determinate des erfolgreichen Alterns

Author: Runge M
Source: MedReport, 2003; 13: 12-13
Doc-ID: 254,

Scientific Publications

Neue Erkenntnisse über den Zusammenhang zwischen Knochenstabilität und Muskelkraft

Author: Schiessl H, Willnecker J
Source: TraumaLinc, 2000; 1:
Keywords: Mechanostat, Muscle-Bone Unit
Doc-ID: 190,

Scientific Publications

Prevention of falls in the elderly trial (PROFET): a randomised controlled trial

BACKGROUND: Falls in elderly people are a common presenting complaint to accident and emergency departments. Current practice commonly focuses on the injury, with little systematic assessment of the underlying weiter...

Author: Close J, Ellis M, Hooper R, Glucksman E, Jackson S, Swift C
Source: Lancet., 1999; 353(9147): 93-7, PMID: 10023893
Doc-ID: 109,

Scientific Publications

Running in the real world: adjusting leg stiffness for different surfaces

A running animal coordinates the actions of many muscles, tendons, and ligaments in its leg so that the overall leg behaves like a single mechanical spring during ground contact. Experimental observations have weiter...

Author: Ferris DP, Louie M, Farley CT
Source: Proc Biol Sci., 1998; 265(1400): 989-94, PMID: 9675909
Doc-ID: 105,

Scientific Publications

Impact of muscle power and force on gait speed in disabled older men and women

BACKGROUND: The purpose of this study was to explore the relationship between muscle power output at different external resistances and performance of functional tasks. The authors hypothesized that power at 40 weiter...

Author: Cuoco A, Callahan DM, Sayers S, Frontera WR, Bean J, Fielding RA
Source: J Gerontol A Biol Sci Med Sci., 2004; 59(11): 1200-6, PMID: 15602076
Doc-ID: 108,

Scientific Publications

Running springs: speed and animal size

Trotting and hopping animals use muscles, tendons and ligaments to store and return elastic energy as they bounce along the ground. We examine how the musculoskeletal spring system operates at different speeds weiter...

Author: Farley CT, Glasheen J, McMahon TA
Source: J Exp Biol., 1993; 185: 71-86, PMID: 8294853
Doc-ID: 106,

Scientific Publications

Soleus H-reflex gain in humans walking and running under simulated reduced gravity

The Hoffmann (H-) reflex is an electrical analogue of the monosynaptic stretch reflex, elicited by bypassing the muscle spindle and directly stimulating the afferent nerve. Studying H-reflex modulation provides weiter...

Author: Ferris DP, Aagaard P, Simonsen EB, Farley CT, Dyhre-Poulsen P
Source: J Physiol., 2001; 530(Pt 1): 167-80, PMID: 11136869
Doc-ID: 107,

Scientific Publications

Runners adjust leg stiffness for their first step on a new running surface

Human runners adjust the stiffness of their stance leg to accommodate surface stiffness during steady state running. This adjustment allows runners to maintain similar center of mass movement (e.g., ground cont weiter...

Author: Ferris DP, Liang K, Farley CT
Source: J Biomech., 1999; 32(8): 787-94, PMID: 10433420
Doc-ID: 104,

Scientific Publications

Passive dynamics change leg mechanics for an unexpected surface during human hopping

Humans running and hopping maintain similar center-of-mass motions, despite large changes in surface stiffness and damping. The goal of this study was to determine the contributions of anticipation and reaction weiter...

Author: Moritz CT, Farley CT
Source: J Appl Physiol., 2004; 97(4): 1313-22, PMID: 15169748
Doc-ID: 103,

Scientific Publications

Neuromuscular changes for hopping on a range of damped surfaces

Humans hopping and running on elastic and damped surfaces maintain similar center-of-mass dynamics by adjusting stance leg mechanics. We tested the hypothesis that the leg transitions from acting like an energy weiter...

Author: Moritz CT, Greene SM, Farley CT
Source: J Appl Physiol., 2004; 96(5): 1996-2004, PMID: 14688034
Doc-ID: 102,

Scientific Publications

Neuromechanical adaptation to hopping with an elastic ankle-foot orthosis

When humans hop or run on different surfaces, they adjust their effective leg stiffness to offset changes in surface stiffness. As a result, the overall stiffness of the leg-surface series combination remains i weiter...

Author: Ferris DP, Bohra ZA, Lukos JR, Kinnaird CR
Source: J Appl Physiol., 2006; 100(1): 163-70, PMID: 16179395
Doc-ID: 101,

Scientific Publications

Reducing frailty and falls in older persons: an investigation of Tai Chi and computerized balance training. Atlanta FICSIT Group. Frailty and Injuries: Cooperative Studies of Intervention Techniques

OBJECTIVE: To evaluate the effects of two exercise approaches, Tai Chi (TC) and computerized balance training (BT), on specified primary outcomes (biomedical, functional, and psychosocial indicators of frailty) weiter...

Author: Wolf SL, Barnhart HX, Kutner NG, McNeely E, Coogler C, Xu T
Source: J Am Geriatr Soc., 1996; 44(5): 489-97, PMID: 8617895
Doc-ID: 54,

Scientific Publications

Wie geht es weiter mit der Messung der Knochendichte

Author: Semler J
Source: Mobiles Leben, 2000; 7: 7-9
Doc-ID: 17,

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