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J Bone Miner Res., 2008; 23(12): 1946-53, PMID: 18684083

Bone structure and volumetric BMD in overweight children: a longitudinal study

Jahr: 2008

Wetzsteon RJ, Petit MA, Macdonald HM, Hughes JM, Beck TJ, McKay HA
Department of Pediatrics, Division of Nephrology, Children"s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.


The effect of excess body fat on bone strength accrual is not well understood. Therefore, we assessed bone measures in healthy weight (HW) and overweight (OW) children. Children (9-11 yr) were classified as HW (n = 302) or OW (n = 143) based on body mass index. We assessed total (ToD) and cortical (CoD) volumetric BMD and bone area, estimates of bone strength (bone strength index [BSI]; stress-strain index [SSIp]), and muscle cross-sectional area (CSA) at the distal (8%), midshaft (50%), and proximal (66%) tibia by pQCT. We used analysis of covariance to compare bone outcomes at baseline and change over 16 mo. At baseline, all bone measures were significantly greater in OW compared with HW children (+4-15%; p
GID: 1655; Letzte Änderung: 02.12.2008