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J Clin Endocrinol Metab., 2009; 94(2): 559-563, PMID: 19033372

Vitamin D status and muscle function in post-menarchal adolescent girls

Jahr: 2009

Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, Mughal Z
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK, M13 9PT; Central Manchester Primary Care Trust, Longsight Health Centre, 526-528 Stockport Road, Longsight, Manchester, M13 0RR; Vitamin D Research Group, Medicine, Univ


Context: There has been a resurgence of vitamin D deficiency among infants, toddlers and adolescents in the United Kingdom. Myopathy is an important clinical symptom of vitamin D deficiency, yet it has not been widely studied. Objective: To investigate the relationship of baseline serum 25-hydroxyvitamin D concentration (25(OH)D) and parathyroid hormone (PTH) with muscle power and force Design: Cross sectional study Setting: Community based in a secondary school Participants: Ninety-nine post-menarchal 12-14 year old females Main outcome measures: Jumping mechanography to measure muscle power, velocity, jump height and Esslinger Fitness Index (EFI) from a two legged counter movement jump and force from multiple one-legged hops. Body height, weight and serum concentrations of 25(OH)D, PTH and calcium (Ca) were measured. Results: Median serum 25(OH)D concentration was 21.3 nmol/L, range 2.5 - 88.5 nmol/L and PTH 3.7 pmol/L (range 0.47 - 26.2 pmol/L). After correction for weight using a quadratic function there was a positive relationship between 25(OH)D and jump velocity (p=0.002), jump height (p = 0.005), power (p = 0.003), Esslinger Fitness Index (p=0.003) and force (p = 0.05). There was a negative effect of PTH upon jump velocity (p = 0.04). Conclusions: From these data we conclude that vitamin D was significantly associated with muscle power and force in adolescent girls.

GID: 1674; Letzte Änderung: 12.12.2008