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J Musculoskelet Neuronal Interact, 2017; 17(2): 1-7, PMID: 28574406

Muscle abnormalities in osteogenesis imperfecta.

Jahr: 2017

Veilleux LN, Trejo P, Rauch F
Shriners Hospital for Children and McGill University, Montreal, Quebec, Canada.

Abstract

Osteogenesis imperfecta (OI) is mainly characterized by bone fragility but muscle abnormalities have been reported both in OI mouse models and in children with OI. Muscle mass is decreased in OI, even when short stature is taken into account. Dynamic muscle tests aiming at maximal eccentric force production reveal functional deficits that can not be explained by low muscle mass alone. However, it appears that diaphyseal bone mass is normally adapted to muscle force. At present the determinants of muscle mass and function in OI have not been clearly defined. Physiotherapy interventions and bisphosphonate treatment appear to have some effect on muscle function in OI. Interventions targeting muscle mass have shown encouraging results in OI animal models and are an interesting area for further research.

Schlagworte: pQCT Muscle
GID: 4474; Letzte Änderung: 12.07.2017
Weitere Informationen: Original Article