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Clinical studies for the application area muscle and bone

Here you will find all clinical studies, listed by date of last update. This category currently includes 534 entries.

Literature (534)

Clinical Studies

Effects of whole body vibration in patients with chronic obstructive pulmonary disease - A randomized controlled trial.

INTRODUCTION: To date endurance and strength training are established and evidence-based exercise methods in patients with chronic obstructive pulmonary disease (COPD). There is an unmet need for further resear weiter...

Author: Gloeckl R, Heinzelmann I, Baeuerle S, Damm E, Schwedhelm AL, Diril M, Buhrow D, Jerrentrup A, Kenn K
Source: Respir Med, 2012; 106(1): 75-83, PMID: 22104540
Doc-ID: 2780,

Clinical Studies

Side-to-side differences in bone strength in master jumpers and sprinters.

Introduction: This study evaluated side-to-side difference in tibial bone structure, calf muscle cross-sectional area (CSA) and hopping force in master athletes as a result of training for sports with different weiter...

Author: Ireland A, Korhonen M, Heinonen A, Suominen H, Baur C, Stevens S, Degens H, Rittweger J
Source: J Musculoskelet Neuronal Interact, 2011; 11(4): 298-305, PMID: 22130138
Doc-ID: 2777,
More information: Original Article

Clinical Studies

Contralateral comparison of bone geometry, BMD and muscle function in the lower leg and forearm after stroke.

Objective: The aim of the study was to investigate the side-to-side differences of the upper and lower limbs in chronic stroke patients by means of peripheral quantitative computed tomography (pQCT). Methods: T weiter...

Author: Talla R, Galea M, Lythgo N, Angeli T, Eser P
Source: J Musculoskelet Neuronal Interact, 2011; 11(4): 306-13, PMID: 22130139
Doc-ID: 2778,
More information: Original Article

Clinical Studies

PLATELET ATP AND L-ARGININE-ASYMMETRICAL DIMETHYLARGININE RATIO IN VIBRATIONAL TRAINING VERSUS AEROBIC TRAINING OF PARKINSON’S DISEASE PATIENTS. A PRELIMINARY STUDY

Background: Nitric oxide (NO) synthases (NOS) produce NO by oxidation of l-arginine (l-Arg). Excessive NO synthesis in the brain has cytotoxic effects1 and in mouse models NOS knockouts are protective after ce weiter...

Author: Bongioanni P, Corbianco S, Dini M, Carraro U, Adami N, Zampieri S, Carboncini M, Giannetti M, Cavallini G, Rossi B
Source: 2011;
Keywords: Parkinson
Doc-ID: 2766,

Clinical Studies

PLATELET ATP AND L-ARGININE-ASYMMETRICAL DIMETHYLARGININE RATIO IN VIBRATIONAL TRAINING VERSUS AEROBIC TRAINING OF PARKINSON’S DISEASE PATIENTS. A PRELIMINARY STUDY

Background: Nitric oxide (NO) synthases (NOS) produce NO by oxidation of l-arginine (l-Arg). Excessive NO synthesis in the brain has cytotoxic effects1 and in mouse models NOS knockouts are protective after ce weiter...

Author: P. Bongioanni, S. Corbianco, M. Dini, U. Carraro, N. Adami, S. Zampieri, M. Carboncini, M. Giannetti, G. Cavallini, B. Rossi
Source: 2011;
Keywords: Parkinson
Doc-ID: 2764,

Clinical Studies

The Muscle Activity In The Lower Limb During Single Legged Hop In Children With Juvienile Idiophathic Arthritis

The one-legged hop was used to assess the muscle function of children diagnosed with Juvenile Idiopathic Arthritis. Vertical hopping relies heavily on the triceps surae musculature, and the calcaneal tendon mak weiter...

Author: Dwyer KD; Kennedy MJ; Lamontagne M; Roth J
Source: ISB, Brussels, 2011; 1162
Doc-ID: 2753,

Clinical Studies

Spezielle Trainingstherapie zur Reduktion der Inflammation bei Anti-Jo-1-Syndrom (Special Training Therapy to Reduce Inflammation in Anti-Jo-1 Syndrome)

Zusammenfassung: Wir berichten über den Fall eines 46-jährigen Patienten mit medikamentös behandeltem Anti-Jo-1-Syndrom. Aufgrund einer progressiven Verschlechterung der Lungenfunktion, Dyspnoe, Abgeschlage weiter...

Author: Greulich T, Müller S, Fechtel J, Nell C, Holland A, Bach JP, Tackenberg B, Schubert H, Kenn K, Vogelmeier C, Koczulla AR
Source: Pneumologie, 2011; Oct;65(10): 624-7
Doc-ID: 2755,

Clinical Studies

Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise.

Protein calcium sensors of the Homer family have been proposed to modulate the activity of various ion channels and nuclear factor of activated T cells (NFAT), the transcription factor modulating skeletal musc weiter...

Author: Salanova M, Bortoloso E, Schiffl G, Gutsmann M, Belavy DL, Felsenberg D, Furlan S, Volpe P, Blottner D
Source: FASEB J, 2011; (): , PMID: 21885651
Keywords: BBR2
Doc-ID: 2748,

Clinical Studies

pQCT measures of bone and muscle are independently associated with falls in women – a principal components analysis

BACKGROUND: falling is often a first step to generate sufficient energy for a fragility fracture fallers have been associated with poor muscle strength and low vitamin D levels fat within muscle has been sugge weiter...

Author: Wong AKO, Bhargava A, Beattie KA, Gordon CL, Pickard L, Webber CE, Papaioannou A, Adachi JD
Source: ASBMR, San Diego, 2011;
Keywords: Muslce Density, Falls
Doc-ID: 2744,

Clinical Studies

Tri-modality comparison of bone structure imaging technologies

BACKGROUND: bone structural quantification desirable to assess fracture risk, not captured by BMD useful for assessing bone formation agents and abnormalities in structural pathologies achieved primarily by th weiter...

Author: Wong AKO, Beattie KA, Webber CE, Inglis D, Pickard L, Cheung AMW, Gordon CL, Papaioannou A, Adachi JD, the CaMos Research Group
Source: ASBMR, SanDiego, 2011;
Doc-ID: 2745,

Clinical Studies

Combined Effects of Whole-Body Vibration, Resistance Exercise, and Vascular Occlusion on Skeletal Muscle and Performance.

The purpose of this study was to evaluate the effects of a new high-intensity training modality comprised of vibration exercise with superimposed resistance exercise and vascular occlusion (vibroX) on skeletal weiter...

Author: Item F, Denkinger J, Fontana P, Weber M, Boutellier U, Toigo M
Source: Int J Sports Med, 2011; 32(10): 781-7, PMID: 21870317
Doc-ID: 2690,

Clinical Studies

12-weeks of Whole Body Vibration with Resistance Exercise is Osteogenic at the Spine

Evidence supports weight-bearing activity as a means to increase bone mineral density (BMD) and lower risk for osteoporosis. Whole body vibration (WBV) training is a novel technique that has been minimally exp weiter...

Author: Almstedt HC, Urbinati CR, Ligouri GC, Spiegel M, Stapleton MR, Shoepe TC
Source: ACSM annual meeting, 2011;
Keywords: lumbar spine
Doc-ID: 2683,

Clinical Studies

Maximum Ground Reaction Force in Relation to Tibial Bone Mass in Children and Adults.

PURPOSE:: To assess maximum voluntary forefoot ground reaction force (Fm1LH) during multiple one-legged hopping (m1LH, a new jumping maneuver) and to determine the correlation between tibial volumetric bone min weiter...

Author: Anliker E, Rawer R, Boutellier U, Toigo M
Source: Med Sci Sports Exerc, (): , PMID: 21502901
Doc-ID: 2632,

Clinical Studies

Assessment of musculoskeletal system in women with jumping mechanography

The purpose of this study was to investigate and add reference data about the musculoskeletal system in women. The mechanography system of the Leonardo weiter...

Author: Dionyssiotis Y, Galanos A, Michas G, Trovas G, Lyritis GP
Source: Int J Womens Health., 2010; 1: 113-8, PMID: 21072281
Doc-ID: 2622,

Clinical Studies

Inter-limb musculoskeletal differences in competitive ten-pin bowlers: A preliminary analysis

Objectives: To compare musculoskeletal characteristics of the loaded and non-loaded forearm and upper leg of competitive ten-pin bowlers. Methods: 10 competitive bowlers (30.6 weiter...

Author: Young KC, Sherk VD, Bemben DA
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 21-6, PMID: 21364271
Doc-ID: 2585,
More information: Original Article

Clinical Studies

Gait analysis using a force-measuring gangway: Intrasession repeatability in healthy adults

Objectives: The goal of the present study was to determine the repeatability of gait parameters measured by a force plate gait analysis system (Leonardo Mechanograph® GW). Methods: Fifteen healthy adult partic weiter...

Author: Veilleux LN, Robert M, Ballaz L, Lemay M, Rauch F
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 27-33, PMID: 21364272
Keywords: Gangway
Doc-ID: 2586,
More information: Original Article

Clinical Studies

Additive impact of alfacalcidol on bone mineral density and bone strength in alendronate treated postmenopausal women with reduced bone mass

Objectives: Assessment of additive impact of alfacalcidol 1 weiter...

Author: Felsenberg D, Bock O, Börst H, Armbrecht G, Beller G, Degner C, Stephan-Oelkers M, Schacht E, Mazor Z, Hashimoto J, Roth HJ, Martus P, Runge M
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 34-45, PMID: 21364273
Doc-ID: 2587,
More information: Original Article

Clinical Studies

Relationship of muscle function to auxology in preterm born children at the age of seven years

BACKGROUND/AIMS: To characterize the relationship between muscle function and auxology in preterm born children. METHODS: Forty-five preterm born children (birth weight < or =1,500 g with mean +/- SD: 1,06 weiter...

Author: Fricke O, Roedder D, Kribs A, Tutlewski B, von Kleist-Retzow JC, Herkenrath P, Roth B, Schoenau E
Source: Horm Res Paediatr., 2010; 73(5): 390-7, PMID: 20389111
Doc-ID: 2573,

Clinical Studies

Reproducibility of jumping mechanography in healthy children and adults

Objectives: To describe mechanographic tests that can be performed by patients with a range of functional abilities and to assess the reproducibility of test results in healthy adults and children. Methods: Fif weiter...

Author: Veilleux LN, Rauch F
Source: J Musculoskelet Neuronal Interact., 2010; 10(4): 256-66, PMID: 21116062
Doc-ID: 2483,
More information: Original Article

Clinical Studies

Neuromuscular performance and bone structural characteristics in young healthy men and women

Muscle mass and strength have been shown to be important factors in bone strength. Low muscular force predisposes to falling especially among elderly. Regular exercise helps to prevent falls and resulting bone weiter...

Author: Rantalainen T, Heinonen A, Komi PV, Linnamo V
Source: Eur J Appl Physiol., 2008; 102(2): 215-22, PMID: 17926061
Doc-ID: 2450,

Clinical Studies

The relationship between isokinetic quadriceps strength test and hop tests for distance and one-legged vertical jump test following anterior cruciate ligament reconstruction

Isokinetic measurements and functional tests are often used to assess function following knee ligament reconstruction using the opposite limb as a control. However, the question of whether the uninvolved leg ma weiter...

Author: Petschnig R, Baron R, Albrecht M
Source: J Orthop Sports Phys Ther., 1998; 28(1): 23-31, PMID: 9653687
Doc-ID: 2436,

Clinical Studies

A Randomized, Controlled Trial of Vitamin D Supplementation upon Musculoskeletal Health in Postmenarchal Females

Context:There has been a resurgence of vitamin D deficiency rickets throughout the developed world, with infants and adolescents being primarily affected. Adolescence is a crucial period for muscle and bone min weiter...

Author: Ward KA, Das G, Roberts SA, Berry JL, Adams JE, Rawer R, Mughal MZ
Source: J Clin Endocrinol Metab., 2010; PMID: 20631020
Doc-ID: 2391,

Clinical Studies

Whole body vibration as an adjunct to static stretching

This study was a randomized control trial. The purpose of this study was twofold: 1) to determine if stretching the hamstrings during whole-body-vibration (WBV) is more effective than static stretching alone; a weiter...

Author: Feland JB, Hawks M, Hopkins JT, Hunter I, Johnson AW, Eggett DL
Source: Int J Sports Med., 2010; 31(8): 584-9, PMID: 20535662
Keywords: Stretching
Doc-ID: 2366,

Clinical Studies

Muscle tissue oxygenation and VEGF in VO-matched vibration and squatting exercise

Exposure to vibration has traditionally been associated with compromised perfusion. This study investigated whether blood supply during whole body vibration (WBV), as an exercise modality, is in proportion to t weiter...

Author: Rittweger J, Moss AD, Colier W, Stewart C, Degens H
Source: Clin Physiol Funct Imaging., 2010; 30(4): 269-78, PMID: 20497445
Doc-ID: 2374,

Clinical Studies

Comparing muscle temperature during static and dynamic squatting with and without whole-body vibration

The aim of this study was to investigate the influence of shallow dynamic squatting (DS) versus static squatting (SS) with or without concurrent side-to-side alternating whole-body vibration (WBV) on vastus lat weiter...

Author: Cochrane DJ, Stannard SR, Firth EC, Rittweger J
Source: Clin Physiol Funct Imaging., 2010; 30(4): 223-9, PMID: 20491843
Keywords: muscle temperature
Doc-ID: 2375,

Clinical Studies

Structural analysis of the human tibia in men with spinal cord injury by tomographic (pQCT) serial scans

Spinal cord injury (SCI), as a primarily neurological disorder that causes muscular atrophy, is well known to be associated with sub-lesional bone losses. These losses are more pronounced from epiphyseal than f weiter...

Author: Rittweger J, Goosey-Tolfrey VL, Cointry G, Ferretti JL
Source: Bone., 2010; 47(3): 511-8, PMID: 20561989
Doc-ID: 2336,

Clinical Studies

Vibration effects on static balance and strength

The purpose of this study was to investigate the effects of a vibration training protocol and a conventional strength training program consisting of similar exercises on knee extensors and flexors strength and weiter...

Author: Spiliopoulou SI, Amiridis IG, Tsigganos G, Economides D, Kellis E
Source: Int J Sports Med., 2010; 31(9): 610-6, PMID: 20589590
Keywords: Balance
Doc-ID: 2319,

Clinical Studies

Jumping mechanography: a potential tool for sarcopenia evaluation in older individuals

Muscular function declines with advancing age and is associated with increased risk for falls and fragility fractures. No single methodology ideally quantitatively evaluates this decline. Jumping mechanography weiter...

Author: Buehring B, Krueger D, Binkley N
Source: J Clin Densitom., 2010; 13(3): 283-91, PMID: 20554231
Doc-ID: 2325,

Clinical Studies

Differential atrophy of the postero-lateral hip and thigh musculature during 60-days bed-rest and the effect of two different countermeasure exercises

Objectives: Data from previous bed-rest studies have demonstrated that the muscle groups of the thigh most susceptible to atrophy during prolonged inactivity include the hamstrings and the vastii. Limited inf weiter...

Author: Miokovic T, Belavy D, Armbrecht G, Felsenberg D
Source: Life in Space for Life on Earth, ESA, Triest, 2010;
Keywords: Galileo Space, Counter Measure, BBR 2
Doc-ID: 2294,
More information: Original Article

Clinical Studies

Evidence for an additional effect of whole-body vibration above resistive exercise alone in preventing bone loss during prolonged bed-rest

Prior work suggests that the addition of whole-body vibration to high-load resistive exercise (RVE) may be more effective in preventing bone loss in spaceflight and its simulation (bed-rest) than resistive exer weiter...

Author: Belavy D, Beller G, Armbrecht G, Bock O, Börst H, Degner C, Gast U, Felsenberg D
Source: Life in Space for Life on Earth, ESA, Triest, 2010;
Keywords: Galileo Space, Counter Measure, BBR 2
Doc-ID: 2295,
More information: Original Article

Clinical Studies

Increased Homer 2a/b expression by Resistive Vibration Exercise (RVE) in unloaded human soleus (SOL) and vastus lateralis (VL) muscle biopsies

Introduction: The molecular mechanisms of human skeletal muscle adaptation following prolonged disuse are still largely unknown. Recently, protein calcium sensors of the homer family (comprised of short and l weiter...

Author: Salanova M, Schiffl G, Gutsmann M, Belavý D, Felsenberg D, Furlan S, Bortoloso B, Volpe P, Blottner D
Source: Life in Space for Life on Earth, ESA, Triest, 2010;
Keywords: Galileo Space, Counter Measure, BBR 2
Doc-ID: 2296,
More information: Original Article

Clinical Studies

55-days bed rest with and without vibration exercise countermeasure: effects on human muscle protein dysregulation

Prolonged bed rest is often adopted as a model for the study of the effects of microgravity in humans, particularly on muscle mass, fiber type distribution as well as on the contractile properties, at the tissu weiter...

Author: Gelfi C, Moriggi M, Vasso M, Fania C, Capitanio D, Salanova M, Rittweger J, Blottner D, Felsenberg D, Cerrettelli P
Source: Life in Space for Life on Earth, ESA, Triest, 2010;
Keywords: Galielo Space, Counter Measure, BBR 1
Doc-ID: 2298,
More information: Original Article

Clinical Studies

Lower-limb muscle atrophy and effect of resistive vibration exercise during 56-day bed-rest

Objectives: Developing more efficient countermeasures for the maintenance of muscle and muscle function in spaceflight is a priority for space agencies. In this work, we examine changes in muscle volume of th weiter...

Author: Belavy D, Miokovic T, Armbrecht G, Rittweger J, Felsenberg D
Source: Life in Space for Life on Earth, ESA, Triest, 2010;
Keywords: Galileo Space, Counter Measure, BBR 1
Doc-ID: 2299,
More information: Original Article

Clinical Studies

Calf muscle x-ray absorption is reduced in patients with chronic spinal cord injury, but not during 90 days of experimental bed rest

BACKGROUND: Immobilisation leads to muscular atrophy. However, certain types of immobilisation, such as e.g. denervation can also cause a fatty degeneration of skeletal muscle. As fat has lower x-ray absorpti weiter...

Author: Rittweger J
Source: Life in Space for Life on Earth, ESA, Triest, 2010;
Keywords: Muskeldichte, MXA
Doc-ID: 2300,
More information: Original Article

Clinical Studies

Muscle cross sectional area and grip torque contraction types are similarly related to pQCT derived bone strength indices in the radii of older healthy adults

Objectives: We sought to identify the variance in radius bone strength indices explained by forearm muscle cross sectional area (MCSA) and isometric (ISO), concentric (CON), or eccentric (ECC) grip torque in he weiter...

Author: Frank AW, Lorbergs AL, Chilibeck PD, Farthing JP, Kontulainen SA
Source: J Musculoskelet Neuronal Interact., 2010; 10(2): 136-41, PMID: 20516630
Doc-ID: 2290,
More information: Original Article

Clinical Studies

Effect of a new physiotherapy concept on bone mineral density, muscle force and gross motor function in children with bilateral cerebral palsy

Objective: The purpose of this study was to determine the effect of a new physiotherapy concept on bone density, muscle force and motor function in bilateral spastic cerebral palsy children. Methods: In a retro weiter...

Author: Stark C, Nikopoulou-Smyrni P, Stabrey A, Semler O, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2010; 10(2): 151-8, PMID: 20516632
Doc-ID: 2292,
More information: Original Article

Clinical Studies

Vibration as an exercise modality: how it may work, and what its potential might be

Whilst exposure to vibration is traditionally regarded as perilous, recent research has focussed on potential benefits. Here, the physical principles of forced oscillations are discussed in relation to vibratio weiter...

Author: Rittweger J
Source: Eur J Appl Physiol., 2010; 108(5): 877-904, PMID: 20012646
Doc-ID: 2284,

Clinical Studies

Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise

Bed rest is a recognized model for muscle atrophy and bone loss in space flight and in clinical medicine. We hypothesized that whole body vibration in combination with resistive exercise (RVE) would be an effec weiter...

Author: Rittweger J, Beller G, Armbrecht G, Mulder E, Buehring B, Gast U, Dimeo F, Schubert H, de Haan A, Stegeman DF, Schiessl H, Felsenberg D
Source: Bone, 2010; 46(1): 137-47, PMID: 19732856
Keywords: BBR2
Doc-ID: 2285,

Clinical Studies

Effect of prolonged bed rest on the anterior hip muscles

Prolonged bed rest and inactivity is known to cause muscular atrophy with previous research indicating that muscles involved in joint stabilisation are more susceptible. The anterior hip muscles are important f weiter...

Author: Dilani Mendis M, Hides JA, Wilson SJ, Grimaldi A, Belavý DL, Stanton W, Felsenberg D, Rittweger J, Richardson C
Source: Gait Posture., 2009; 30(4): 533-7, PMID: 19726188
Keywords: BBR
Doc-ID: 2286,

Clinical Studies

Changes in joint angle, muscle-tendon complex length, muscle contractile tissue displacement, and modulation of EMG activity during acute whole-body vibration

It has been suggested that vibration causes small changes in muscle length, but to the best of our knowledge, these have yet to be demonstrated during whole-body vibration (WBV). This was an observational study weiter...

Author: Cochrane DJ, Loram ID, Stannard SR, Rittweger J
Source: Muscle Nerve., 2009; 40(3): 420-9, PMID: 19618430
Doc-ID: 2287,

Clinical Studies

Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism

During and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whil weiter...

Author: Armbrecht G, Belavý DL, Gast U, Bongrazio M, Touby F, Beller G, Roth HJ, Perschel FH, Rittweger J, Felsenberg D
Source: Osteoporos Int., 2010; 21(4): 597-607, PMID: 19536451
Keywords: BBR
Doc-ID: 2288,

Clinical Studies

EMG activity during whole body vibration: motion artifacts or stretch reflexes

The validity of electromyographic (EMG) data recorded during whole body vibration (WBV) is controversial. Some authors ascribed a major part of the EMG signal to vibration-induced motion artifacts while others weiter...

Author: Ritzmann R, Kramer A, Gruber M, Gollhofer A, Taube W
Source: Eur J Appl Physiol., 2010; 110(1): 143-51, PMID: 20419311
Keywords: Strech Reflex
Doc-ID: 2242,

Clinical Studies

Reference graphs of age-related changes in bone mass, volumetric density, design and strength of muscle-bone interactions in normal men and women.

Author: Feldman S, Capozza RF, Cointry GR, Ferretti SE, Reina PS, Homse B, Zapata M, Mansur JL, Ferretti JL
Source: ASBMR, 2007;
Doc-ID: 2224,
Download:

Clinical Studies

Relationships between diaphyseal geometry and cortical mineral density as assessed by pQCT in the human tibia. A pQCT study.

Author: Capozza R, Reina P, Cointry G, Feldman S, Castellini S, Rittweger J, Ferretti JL
Source: ASBMR, 2007;
Doc-ID: 2226,
Download:

Clinical Studies

Trabecular bone mass evaluation as related to cortical mass in the human leg. A pQCT study.

Author: Cointry GR, Capozza RF, Feldman S, Mortarino P, Maffei L, Alvarisqueta A, Ferretti JL
Source: ASBMR, 2007;
Doc-ID: 2227,
Download:

Clinical Studies

Non-invasive (pQCT) biomechanical analysis of the whole human tibia in normal men and women

Author: Feldman S, Capozza R, Mortario P, Yelin I, Reina P, Schiessl H, Rittweger J, Ferretti JL, Cointry GR
Source: ASBMR, 2009;
Doc-ID: 2228,
Download:

Clinical Studies

Structural and biomechanical analysis of the whole tibia by pQCT in trained long-distance runners

Author: Feldman S, Capozza R, Mortarino P. Yelin I, Reina P, Ullna MR, Rittweger J, Ferretti JL, Cointry GR
Source: ASBMR, 2009;
Doc-ID: 2229,
Download:

Clinical Studies

Age-Related Changes in Physical Function in Community-Dwelling People Aged 50-79 Years

[Purpose] We aimed to obtain the mean values for physical function tests in healthy community-dwelling people aged 50-79 years and to compare these values between age decades. [Subjects and Methods] We recr weiter...

Author: Tsubaki A, Kubo M, Kobayashi R, Jigami H, Takahashi HE
Source: J. Phys. Ther. Sci, 2010; 22/1: 23-27
Doc-ID: 2231,
More information: Original Article

Clinical Studies

Structural analysis of the human tibia by tomographic (pQCT) serial scans

Abstract This study analyses the evaluation of tomographic indicators of tibia structure, assuming that the usual loading pattern shifts from uniaxial compression close to the heel to a combined compression, to weiter...

Author: Capozza RF, Feldman S, Mortarino P, Reina PS, Schiessl H, Rittweger J, Ferretti JL, Cointry GR
Source: J Anat., 2010; 216: 470 -481, PMID: 20136670
Doc-ID: 2194,

Clinical Studies

Vibration treatment in cerebral palsy: A randomized controlled pilot study

In this 6-month trial, twenty children with cerebral palsy (age 6.2 to 12.3 years; 6 girls) were randomized to either continue their school physiotherapy program unchanged or to receive 9 minutes of side-altern weiter...

Author: Ruck J, Chabot G, Rauch F
Source: J Musculoskelet Neuronal Interact., 2010; 10(1): 77-83, PMID: 20190383
Doc-ID: 2173,
More information: Original Article

Clinical Studies

Mechanographic analyses in pediatrics: allometric scaling of "peak jump force" and its relationship to "maximal isometric grip force" in childhood and adolescence

BACKGROUND: Kinetic analyses of the neuromuscular system have become an important part in the diagnostics of metabolic bone disorders in pediatrics because of the relevance of the "Functional Muscle-Bone Unit". weiter...

Author: Fricke O, Stabrey A, Tutlewski B, Schoenau E
Source: Klin Padiatr., 2009; 221(7): 436-9, PMID: 20013567
Doc-ID: 2156,

Clinical Studies

Building a Better Understanding of Basic Mechanical Principles Through Analysis of the Vertical Jump

An understanding of the basic mechanical principles governing movement is essential for the development of training programs, performance improvement, and injury prevention. The goal of this article is to revie weiter...

Author: Reiser RF, Rocheford EC, Armstrong CJ
Source: Strength and conditioning journal, 2006; 28(4): 70-80
Doc-ID: 2135,

Clinical Studies

EFFECT OF SPORT ACTIVITY ON COUNTER MOVEMENT JUMP PARAMETERS IN JUVENILE STUDENTS

INTRODUCTION: The counter movement jump (CMJ) is a commonly used method in performance diagnostics to measure leg power (Frick et al., 1991). The use of arm movements during jumping can increase the release ve weiter...

Author: Richter A, Lang D, Strutzenberger G, Schwameder H
Source: ISBS, Conference Proceedings Archive, 27 International Conference on Biomechanics in Sports (2009), 2009;
Doc-ID: 2124,
More information: Original Article

Clinical Studies

Bone loss in Pompe disease: novel application of Vibration Training and High Resolution peripheral Quantitative Computed Tomography (HR-pQCT)

Author: Khan Q, Boyd S, Ramage B, Robu I, McNeil C, Hanley D, Casey R
Source: 2009;
Doc-ID: 2107,

Clinical Studies

Skeletal geometry and indices of bone strength in artistic gymnasts

This review addresses bone geometry and indices of skeletal strength associated with exposure to gymnastic loading during growth. A brief background characterizes artistic gymnastics as a mechanical loading mod weiter...

Author: Dowthwaite JN, Scerpella TA
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 198-214, PMID: 19949278
Doc-ID: 2109,
More information: Original Article

Clinical Studies

Acute whole-body vibration elicits post-activation potentiation

Whole-body vibration (WBV) leads to a rapid increase in intra-muscular temperature and enhances muscle power. The power-enhancing effects by WBV can, at least in part, be explained by intra-muscular temperature weiter...

Author: Cochrane DJ, Stannard SR, Firth EC, Rittweger J
Source: Eur J Appl Physiol., 2009; PMID: 19795130
Keywords: BBR2
Doc-ID: 2098,

Clinical Studies

Age comparisons of bone density and geometry in men

Objectives: The purposes of this study were to examine tibia bone density and geometry in young and middle aged men, and to explore relationships between pQCT- and DXA-derived body composition variables. Method weiter...

Author: Sherk VD, Karabulut M, Bemben MG, Bemben DA
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 256-62, PMID: 19949283
Doc-ID: 2086,
More information: Original Article

Clinical Studies

Muscle and bone adaptations after treadmill training in incomplete Spinal Cord Injury: a case study using peripheral Quantitative Computed Tomography

We describe the use of peripheral Quantitative Computed Tomography (pQCT) to identify musculoskeletal responses to partial body-weight supported treadmill training (BWSTT) in incomplete spinal cord injury (SCI) weiter...

Author: Coupaud S, Jack LP, Hunt KJ, Allan DB
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 288-97, PMID: 19949287
Doc-ID: 2087,
More information: Original Article

Clinical Studies

Age-dependency in bone mass and geometry: a pQCT study on male and female master sprinters, middle and long distance runners, race-walkers and sedentary people

Objective: To investigate whether athletic participation allows master athletes to preserve their good bone health into old age. Methods: Bone strength indicators of the tibia and the radius were obtained of ma weiter...

Author: Wilks DC, Winwood K, Gilliver SF, Kwiet A, Sun LW, Gutwasser C, Ferretti JL, Sargeant AJ, Felsenberg D, Rittweger J
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 236-46, PMID: 19949281
Keywords: Master Athletes
Doc-ID: 2084,
More information: Original Article

Clinical Studies

Resistive vibration exercise reduces lower limb muscle atrophy during 56-day bed-rest

Objectives: The current study aimed to examine the effectiveness of a resistive vibration exercise countermeasure during prolonged bed-rest in preventing lower-limb muscle atrophy. Methods: 20 male subjects und weiter...

Author: Belavý DL, Miokovic T, Armbrecht G, Rittweger J, Felsenberg D
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 225-35, PMID: 19949280
Keywords: BBR, Galileo Space
Doc-ID: 2083,
More information: Original Article

Clinical Studies

Comparison of pQCT parameters between ulna and radius in retired elite gymnasts: the skeletal benefits associated with long-term gymnastics are bone- and site-specific

Objectives: To compare the skeletal benefits associated with gymnastics between ulna and radius. Methods: 19 retired artistic gymnasts, aged 18-36 years, were compared to 24 sedentary women. Bone mineral conten weiter...

Author: Ducher G, Hill BL, Angeli T, Bass SL, Eser P
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 247-55, PMID: 19949282
Doc-ID: 2085,
More information: Original Article

Clinical Studies

Normative values for maximum power during motor function assessment of jumping among physically active Japanese

Objectives: To determine the relationship between maximum power relative to body weight (Pmax-rel) and the aging process, and to indicate the target values of improvement of motor function in Japanese individua weiter...

Author: Tsubaki A, Kubo M, Kobayashi R, Jigami H, Takahashi HE
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 263-7, PMID: 19949284
Keywords: Leonardo Normative Data
Doc-ID: 2082,
More information: Original Article

Clinical Studies

Examining the developing skeletal muscle: Why, what and how

This review focuses on methodological concepts in the evaluation of skeletal muscle function, taking into account classical muscle physiology, the developing motor system in children and anthropometric paramete weiter...

Author: Fricke O, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2005; 5(3): 225-31, PMID: 16172513
Doc-ID: 2074,
More information: Original Article

Clinical Studies

The "Functional Muscle-Bone Unit": probing the relevance of mechanical signals for bone development in children and adolescents

The present text deals with the relationship of muscle force and mass to bone mass and geometry in the developing skeleton of children and adolescents. Recent results of the last ten years are discussed with re weiter...

Author: Fricke O, Schoenau E
Source: Growth Horm IGF Res., 2007; 17(1): 1-9, PMID: 17194607
Doc-ID: 2076,

Clinical Studies

Leistungsoptimierung im Rahmen eines 8-wöchigen Vibrationstrainings und der Einsatz eines Kohärenzmessgerätes im Leistungssport

Author: Wegner R, Ziaja C, Witt J, Weinberg P, Baur C
Source: Leistungssport, 2009; 6: 22-24
Keywords: Leistung, Galileo, Leichtathletik, Balance, Einbeinstand
Doc-ID: 2035,

Clinical Studies

Electromyographic Activity During Whole Body Vibration: Motion Artifacts or Strech Reflex Responses?

Introduction: The validity of electromyographic (EMG) data recorded during whole body vibration (WBV) is discussed controversially. Some authors have suggested filtering because of vibration-induced motion art weiter...

Author: Kramer A, Ritzmann R, Gruber M, Gollhofer A, Taube W
Source: ECSS, Oslo, 2009;
Doc-ID: 2038,
More information: Original Article

Clinical Studies

Influence of vibration resistance training on knee extensor and plantar flexor size, strength, and contractile speed characteristics after 60 days of bed rest

Spaceflight and bed rest (BR) result in loss of muscle mass and strength. This study evaluated the effectiveness of resistance training and vibration-augmented resistance training to preserve thigh (quadriceps weiter...

Author: Mulder ER, Horstman AM, Stegeman DF, de Haan A, Belavý DL, Miokovic T, Armbrecht G, Felsenberg D, Gerrits KH
Source: J Appl Physiol., 2009; 107(6): 1789-98, PMID: 19797694
Keywords: BBR2
Doc-ID: 2013,

Clinical Studies

Einfluss von dynamischem Krafttraining mit und ohne Vibration auf Knochenmasse und -festigkeit bei postmenopausalen Frauen [Influence of Resistance Training with and without vibration on Bone Mass and Strength in Postmenopausal Women]

Einleitung: Das Skelettsystem unterliegt lebenslang einem regen Umbauprozess, bei dem sich Knochenmasse und -architektur der sich ändernden mechanischen Beanspruchung anpassen. Bei älteren Menschen liegen d weiter...

Author: Kleinmond C
Source: Dissertation, 2002;
Doc-ID: 1976,
More information: Original Article

Clinical Studies

Auswirkungen von erschöpfendem Ganzkörpervibrationstraining auf neuromuskuläre Parameter im Vergleich zu erschöpfendem Kniebeugentraining [Effect of exhausive whole body vibration exercise on neuromuscular parameters compared to exhaustive squatting exer

Studienziel war die Auswirkungen von erschöpfendem Ganzkörpervibrationstraining auf das neuromuskuläre System gesunder Probanden explorativ zu erforschen und mit normalem Training mit Kniebeugen zu vergleich weiter...

Author: Mutschelknauss M
Source: Dissertation, 2006;
Doc-ID: 1977,
More information: Original Article

Clinical Studies

Physiologischer Einfluss adrenaler Androgene und Glucocorticoide auf den Unterarmknochen im Wachstumsalter bei gesunden Kindern [The physiological influence of adrenal androgens and glucococorticoids on forearm bone of healthy children during growth]

Der positive Einfluss von gonadalen Steroiden auf die Knochenmasse ist längst belegt. Bei einem im Wachstumsalter supraphysiologischen Sekretionsniveau (z.B. bei prämaturer Pubarche) können adrenale Androgen weiter...

Author: Boye KR
Source: Dissertation, 2006;
Doc-ID: 1980,
More information: Original Article

Clinical Studies

Der Voraussagewert von neuromuskulären Tests für das Sturzrisiko und das damit assoziierte Frakturrisiko bei postmenopausalen Frauen [Value of prediction of neuromuscular tests for risk of fall and the associated risk of fracture in postmenopausal women]

Die Voraussagekraft eines einzelnen Risikofaktors für das Vorhandensein einer Osteoporose ist relativ gering. Die Bemühungen zur Erstellung eines Risikoscores, der eine bestimmte Konstellation von Risikofakto weiter...

Author: Degner C
Source: Dissertation, 2006;
Doc-ID: 1981,
More information: Original Article

Clinical Studies

Notwendigkeit und Wirksamkeit adjuvanter Schmerztherapie bei der Behandlung der primären Osteoporose und deren Einfluss auf die Lebensqualität [Influence of adjuvant pain medication on quality of life in the treatment of postmenopausal osteoporosis]

Der chronische Rückenschmerz ist das Hauptsymptom der postmenopausalen Osteoporose und mindert die Mobilität und Lebensqualität der Patientinnen. Die vorliegende prospektive, pseudorandomisierte Studie verg weiter...

Author: Ullrich H
Source: Dissertation Dissertation, 2009;
Doc-ID: 1982,
More information: Original Article

Clinical Studies

Die Osteoporose des Mannes: Eine klinische Querschnittsanalyse [Osteoporosis in Men: A Clinical Cross Sectional Analysis]

Anhand eines Patientenkollektivs, das in einer Universitätsklinik einer großen mitteleuropäischen Hauptstadt in einem Zeitraum von dreieinhalb Jahren zur Knochendichtemessung überwiesen wurde, sollte ein kl weiter...

Author: Valentine SM
Source: Dissertation, 2001;
Doc-ID: 1983,
More information: Original Article

Clinical Studies

Experimentelle und klinische Validierung der mittels peripherer Quantitativer Computertomographie (pQCT) berechneten biomechanischen Parameter Flächenträgheitsmoment I, Widerstandsmoment W und anderer Festigkeitsindices

Die Zielsetzung dieser Arbeit war die Überprüfung der Richtigkeit der Berechnung der Biegesteifigkeit peripherer Knochen mittels pQCT Messung und deren dichtebasierte Berechnung des Flächenträgheitsmomentes weiter...

Author: Beller GR
Source: Dissertation, 2008;
Doc-ID: 1974,
More information: Original Article

Clinical Studies

Bone Loss and Recovery following

Author: Fard-Shirazi Y, Kupke JS, Lucas MW, Greene ES, Swift JM, Thomson JV, Schepp BD, Bloomfield SA, Hogan HA
Source: ASBMR, 2009;
Doc-ID: 1955,

Clinical Studies

Side-alternating vibration training improves muscle performance in a patient with late-onset pompe disease

Side-alternating vibration training (SAVT) was used for 15 weeks in a patient with Late-onset Pompe disease who had never used enzyme replacement or chaperone therapy. Prior to the use of SAVT, the patient had weiter...

Author: Khan A, Ramage B, Robu I, Benard L
Source: Case Report Med., 2009; 2009: 741087, PMID: 19710926
Doc-ID: 1953,
More information: Original Article

Clinical Studies

Association between long-term consumption of soft drinks and variables of bone modeling and remodeling in a sample of healthy German children and adolescents

BACKGROUND: Soft drinks are thought to displace milk in diets of children and adolescents and therefore might affect variables of bone modeling and remodeling. OBJECTIVE: We assessed the association between lon weiter...

Author: Libuda L, Alexy U, Remer T, Stehle P, Schoenau E, Kersting M
Source: Am J Clin Nutr., 2008; 88(6): 1670-7, PMID: 19064530
Doc-ID: 1941,

Clinical Studies

The acute effect of vibration exercise on concentric muscular characteristics

This study was designed to compare the acute effect of vibration exercise with a concentric-only activity (arm cranking) on concentric-only muscle action using an upper body isoinertial exercise. Twelve healthy weiter...

Author: Cochrane DJ, Stannard SR, Walmsely A, Firth EC
Source: J Sci Med Sport., 2008; 11(6): 527-34, PMID: 17714990
Keywords: Galileo Dumbbell, Galileo Hantel, Vibrationshantel, vibrating Bumbbell
Doc-ID: 1945,

Clinical Studies

History of amenorrhoea compromises some of the exercise-induced benefits in cortical and trabecular bone in the peripheral and axial skeleton: a study in retired elite gymnasts

BACKGROUND: Female gymnasts frequently present with overt signs of hypoestrogenism, such as late menarche or menstrual dysfunction. The objective was to investigate the impact of history of amenorrhoea on the e weiter...

Author: Ducher G, Eser P, Hill B, Bass S
Source: Bone., 2009; 45(4): 760-7, PMID: 19573632
Doc-ID: 1922,

Clinical Studies

Influence of exercise mode and osteogenic index on bone biomarker responses during short-term physical training

Prescribing exercise based on intensity, frequency, and duration of loading may maximize osteogenic responses in bone, but a model of the osteogenic potential of exercise has not been established in humans. In weiter...

Author: Lester ME, Urso ML, Evans RK, Pierce JR, Spiering BA, Maresh CM, Hatfield DL, Kraemer WJ, Nindl BC
Source: Bone., 2009; 45(4): 768-76, PMID: 19520194
Doc-ID: 1923,

Clinical Studies

Correlation of pQCT bone strength index with mechanical testing in distraction osteogenesis

Distraction osteogenesis is an established method of treatment of non-unions and limb length discrepancies. Despite improvements in surgical techniques and fixation devices there is still a considerable possibi weiter...

Author: Kokoroghiannis C, Charopoulos I, Lyritis G, Raptou P, Karachalios T, Papaioannou N
Source: Bone., 2009; 45(3): 512-6, PMID: 19497394
Doc-ID: 1926,

Clinical Studies

Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment

In a population-based cross-sectional study, we examined effects of sex and age on bone microstructure at the wrist using high-resolution 3-D pQCT. Compared with women, men had thicker trabeculae in young adult weiter...

Author: Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, Peterson JM, Melton LJ 3rd
Source: J Bone Miner Res., 2006; 21(1): 124-31, PMID: 16355281
Doc-ID: 1938,
More information: Original Article

Clinical Studies

Metaanalyse zur Veränderung der Leistungsfähigkeit durch Vibrationstraining

Problemstellung: Inwiefern können durch Vibrationstraining positive Veränderungen der Leistungsfähigkeit erzielt werden. Methode: In der Metaanalyse wurden Studien eingeschlossen, die zwischen den Jahren 9 weiter...

Author: Baur C
Source: Deutsche Zeitschrift für Sportmedizin, 2007;
Doc-ID: 1900,

Clinical Studies

Auswirkung eines Vibrations- und Krafttrainings auf die Beinmuskulatur bei Gonarthrose Patienten Efficiency of Vibration or Strength Training for Knee Stability in Osteoarthritis of the Knee

(English) Background: The diagnosis of osteoarthritis of the knee is becoming more common as life expectancy increases. Strength training has been proven to be an effective treatment. The aim of the present weiter...

Author: Rapp W, Boeer J, Albrich C, Heitkamp HC
Source: Akt Rheumatol, 2009; 10.1055/s-0029-1225366:
Doc-ID: 1886,

Clinical Studies

Harninkontinenz - Vibrationstraining befreit von Harninkontinenz

Dauer: 12 Wochen Studie: Geprüft wurde das Verfahren bei 90 Frauen mit Stress-Harninkonzinenz. In einer multizentrischen Studie nahm ein Drittel der Frauen zuerst an einem herkömmlichen Beckenbodentraini weiter...

Author: Viereck V
Doc-ID: 1871,
Download:

Clinical Studies

Assessment of material, structural, and functional properties of the human skeleton by pQCT systems

Peripheral quantitative computed tomography (pQCT) systems measure bone parameters noninvasively using low radiation doses. This limits image resolution but is practical for the diagnosis and quantitative monit weiter...

Author: Roldán EJ, Bogado CE
Source: Curr Osteoporos Rep., 2009; 7(2): 37-41, PMID: 19631026
Doc-ID: 1844,

Clinical Studies

Precision of the XCT 3000 and comparison of densitometric measurements in distal radius scans between XCT 3000 and XCT 2000 peripheral quantitative computed tomography scanners.

Researchers conducting longitudinal studies face challenges as technology evolves and data collection equipment is upgraded from older to newer models. In this study, we report precision error and associations weiter...

Author: Koenig C, Wey H, Binkley T.
Source: J Clin Densitom., 2008; Oct-Dec;11(4):: 575-80, PMID: 18715808
Doc-ID: 1846,

Clinical Studies

Muscle mass during childhood--relationship to skeletal development

Bone densitometric data often are difficult to interpret in children and adolescents because of large inter- and intraindividual variations in bone size. Here, we propose a functional approach to bone densitome weiter...

Author: Schoenau E, Neu MC, Manz F
Source: J Musculoskelet Neuronal Interact., 2004; 4(1): 105-8, PMID: 15615084
Doc-ID: 1852,
More information: Original Article

Clinical Studies

Influence of weight reduction on muscle performance and bone mass, structure and metabolism in obese premenopausal women.

Muscle performance, body composition and bone mass at the lumbar spine and proximal femur with DXA, structural traits at the tibia and radius with pQCT, and biomarkers of bone metabolism were assessed at baseli weiter...

Author: Uusi-Rasi K, Sievanen H, Kannus P, Pasanen M, Kukkonen-Harjula K, Fogelholm M.
Source: J Musculoskelet Neuronal Interact., 2009; 9(2):72-80: , PMID: 19516082
Doc-ID: 1836,
More information: Original Article

Clinical Studies

Bone mineral density alterations in upper and lower extremities 12 months after stroke measured by peripheral quantitative computed tomography and DXA.

To evaluate the loss of trabecular and cortical bone mineral density (BMD) and geometric parameters of bone strength expressed by stress-strain index (SSI) in the proximal and distal forearm and the alterations weiter...

Author: Lazoura O, Groumas N, Antoniadou E, Papadaki PJ, Papadimitriou A, Thriskos P, Fezoulidis I, Vlychou M.
Source: J Clin Densitom., 2008; 11(4):: 511-7, PMID: 18639477
Doc-ID: 1837,

Clinical Studies

Platform accelerations of three different whole-body vibration devices and the transmission of vertical vibrations to the lower limbs

Physical whole-body vibration (WBV) exercises become available at various levels of intensity. In a first series of measurements, we investigated 3-dimensional platform accelerations of three different WBV devi weiter...

Author: Pel JJ, Bagheri J, van Dam LM, van den Berg-Emons HJ, Horemans HL, Stam HJ, van der Steen J
Source: Med Eng Phys., 2009; 31(8): 937-44, PMID: 19523867
Doc-ID: 1828,

Clinical Studies

Fitness efficacy of vibratory exercise compared to walking in postmenopausal women

In this study, we compared the efficacy of 8 months of low-frequency vibration and a walk-based program in health-related fitness. Twenty-seven postmenopausal women were randomly assigned into two groups: whole weiter...

Author: Raimundo AM, Gusi N, Tomas-Carus P
Source: Eur J Appl Physiol., 2009; 106(5): 741-8, PMID: 19434420
Doc-ID: 1829,

Clinical Studies

Intensity, repetitiveness, and directionality of habitual adolescent mobility patterns influence the tibial diaphysis morphology of athletes.

Mobility patterns affect the loads placed on the lower limbs during locomotion and may influence variation in lower limb diaphyseal robusticity and shape. This relationship commonly forms the basis for inferrin weiter...

Author: Shaw CN, Stock JT.
Source: Am J Phys Anthropol., 2009; Apr 8.:
Doc-ID: 1811,

Clinical Studies

Habitual throwing and swimming correspond with upper limb diaphyseal strength and shape in modern human athletes.

Variation in upper limb long bone cross-sectional properties may reflect a phenotypically plastic response to habitual loading patterns. Structural differences between limb bones have often been used to infer p weiter...

Author: Shaw CN, Stock JT.
Source: Am J Phys Anthropol., 2009; Apr 8.:
Doc-ID: 1812,

Clinical Studies

Use of whole-body vibration as a mode of warming up before counter movement jump

Letter to the Editor weiter...

Author: Artero EG, España-Romero V, Ortega FB, Jiménez-Pavón D, Carreño-Gálvez F, Ruiz JR, Castillo ÁG, Castillo MJ
Source: Journal of Sports Science and Medicine, 2007; 6: 574-575
Doc-ID: 1806,
More information: Original Article

Clinical Studies

Bone mass and geometry of the tibia and the radius of master sprinters, middle and long distance runners, race-walkers and sedentary control participants: A pQCT study

Mechanical loading is thought to be a determinant of bone mass and geometry. Both ground reaction forces and tibial strains increase with running speed. This study investigates the hypothesis that surrogates of weiter...

Author: Wilks DC, Winwood K, Gilliver SF, Kwiet A, Chatfield M, Michaelis I, Sun LW, Ferretti JL, Sargeant AJ, Felsenberg D, Rittweger J
Source: Bone., 2009; PMID: 19332164
Doc-ID: 1800,

Clinical Studies

Long-Term Leisure Time Physical Activity and Properties of Bone: A Twin Study

Abstract Effects of physical activity on bone properties when controlled for genetic effects are not fully understood. We aimed to investigate association between long-term leisure time physical activity (LTPA) weiter...

Author: Ma H, Leskinen T, Alen M, Cheng S, Sipilä S, Heinonen A, Kaprio J, Suominen H, Kujala UM
Source: J Bone Miner Res., 2009; 24/8: 1427-33, PMID: 19335223
Doc-ID: 1801,

Clinical Studies

Study of bone density by pQCT analysis in healthy adults and patients with B-thalassemia major and intermedia

BACKGROUND: Bone changes are a prominent symptom of beta-thalassemias, related to expansion of bone marrow and reduction of bone density. Conventional treatment ameliorates bone changes and improves survival, t weiter...

Author: Ladis V, Raptou P, Rigatou E, Chouliaras G, Galanos A, Korres D, Kattamis C
Source: Pediatr Endocrinol Rev., 2008; 6 Suppl 1: 127-31, PMID: 19360988
Doc-ID: 1804,

Clinical Studies

Muscle indices do not fully account for enhanced upper extremity bone mass and strength in gymnasts

OBJECTIVES: Muscular forces are an important determinant of bone strength, but bone may also adapt to non-muscular loading. We tested the hypothesis that loads associated with childhood gymnastics yield high ar weiter...

Author: Dowthwaite JN, Kanaley JA, Spadaro JA, Hickman RM, Scerpella TA
Source: J Musculoskelet Neuronal Interact., 2009; 9(1): 2-14, PMID: 19240362
Doc-ID: 1797,
More information: Original Article

Clinical Studies

Quantification of bone mineral density precision according to repositioning errors in peripheral quantitative computed tomography (pQCT) at the radius and tibia

Peripheral quantitative computed tomography (pQCT) is increasingly being used to measure bone mineral density (BMD) in both research and clinical practice to monitor BMD changes. Repeated measurements in long-t weiter...

Author: Sun L, Beller G, Felsenberg D
Source: J Musculoskelet Neuronal Interact., 2009; 9(1): 18-24, PMID: 19240364
Doc-ID: 1798,
More information: Original Article

Clinical Studies

Evaluation of pharmaceuticals with a novel 50-hour animal model of bone loss

Osteoporosis remains a major public health problem through its associated fragility fractures. Several animal models for the study of osteoporotic bone loss, such as ovariectomy (OVX) and denervation, require s weiter...

Author: Tomimori Y, Mori K, Koide M, Nakamichi Y, Ninomiya T, Udagawa N, Yasuda H
Source: J Bone Miner Res., 2009; 24(7): 1194-205, PMID: 19257825
Doc-ID: 1735,

Clinical Studies

Skeletal Muscle and Mortality Results From the InCHIANTI Study

BACKGROUND: Sarcopenia, the age-related loss of muscle mass, may not be an isolated process but is associated with an increase in fat mass. The aim of this study was to estimate the mortality risk of sarcopenia weiter...

Author: Cesari M, Pahor M, Lauretani F, Zamboni V, Bandinelli S, Bernabei R, Guralnik JM, Ferrucci L
Source: J Gerontol A Biol Sci Med Sci., 2009; 64(3): 377-84, PMID: 19181709
Doc-ID: 1737,

Clinical Studies

Pelvic floor stimulation: what are the good vibrations

OBJECTIVE: The aim of this study was to determine if two different whole body vibration, sinusoidal vibration (SV) and stochastic resonance vibration (SRV), using various intensities lead to a reactive activati weiter...

Author: Lauper M, Kuhn A, Gerber R, Luginbühl H, Radlinger L
Source: Neurourol Urodyn., 2009; 28(5): 405-10, PMID: 19283866
Keywords: EMG Data: Galileo vs. Zeptor SRT
Doc-ID: 1739,

Clinical Studies

Load-specific differences in the structure of femoral neck and tibia between world-class moguls skiers and slalom skiers

Bone structure of weight-bearing proximal femur and tibia was examined among the Finnish world-class moguls skiers and slalom skiers. We hypothesized that these bones, during typical sport-specific performance, weiter...

Author: Nikander R, Sievänen H, Heinonen A, Karstila T, Kannus P
Source: Scand J Med Sci Sports., 2008; 18(2): 145-53, PMID: 18067528
Doc-ID: 1733,

Clinical Studies

Recovery of muscle atrophy and bone loss from 90 days bed rest: results from a one-year follow-up

Earlier studies found the recovery of bone loss after clinical immobilization to be incomplete. It has been argued that this is due to the human skeleton"s inability to accrue bone mass once peak bone mass has weiter...

Author: Rittweger J, Felsenberg D
Source: Bone., 2009; 44(2): 214-24, PMID: 19022418
Keywords: BedRest
Doc-ID: 1734,

Clinical Studies

Distal Radius Strength: A Comparison of DXA-Derived vs pQCT-Measured Parameters in Adolescent Females

Although quantitative computed tomography (QCT) is considered the gold standard for in vivo densitometry, dual-energy X-ray absorptiometry (DXA) scans assess larger bone regions and are more appropriate for ped weiter...

Author: Dowthwaite JN, Hickman RM, Kanaley JA, Ploutz-Snyder RJ, Spadaro JA, Scerpella TA
Source: J Clin Densitom., 2009; 12(1): 42-53, PMID: 19084448
Doc-ID: 1732,

Clinical Studies

Body composition, volumetric and areal bone parameters in male-to-female transsexual persons

CONTEXT: Male-to-female (M-->F) transsexual persons undergo extreme changes in gonadal hormone concentrations, both by pharmacological and surgical interventions. Given the importance of sex steroids for develo weiter...

Author: Lapauw B, Taes Y, Simoens S, Van Caenegem E, Weyers S, Goemaere S, Toye K, Kaufman JM, T"Sjoen GG
Source: Bone., 2008; 43(6): 1016-21, PMID: 18835591
Keywords: transsexual, body composition, bone size
Doc-ID: 1727,

Clinical Studies

Well-nourished cystic fibrosis patients have normal mineral density, but reduced cortical thickness at the forearm

SUMMARY: Our goal was to assess mineral density and geometry of the cortex at the level of the forearm in adolescents and young adults with cystic fibrosis, using peripheral quantitative computed tomography. We weiter...

Author: Louis O, Clerinx P, Gies I, De Wachter E, De Schepper J
Source: Osteoporos Int., 2009; 20(2): 309-14, PMID: 18536951
Keywords: cystic fibrosis bone geometry cortical thickness
Doc-ID: 1729,

Clinical Studies

The effects of acute whole body vibration as a recovery modality following high-intensity interval training in well-trained, middle-aged runners

The main purpose of the present study was to examine the effects of acute whole body vibration (WBV) on recovery following a 3 km time trial (3 km TT) and high-intensity interval training (HIIT) (8 x 400 m). Po weiter...

Author: Edge J, Mündel T, Weir K, Cochrane DJ
Source: Eur J Appl Physiol., 2009; 105(3): 421-8, PMID: 19011891
Doc-ID: 1709,

Clinical Studies

Acute enhancement of lower-extremity dynamic strength and flexibility with whole-body vibration

The purpose of this investigation was to examine the acute effects of whole-body vibration (WBV) on muscular strength, flexibility, and heart rate (HR). Twenty adults (10 men, 10 women) untrained to WBV partici weiter...

Author: Jacobs PL, Burns P
Source: J Strength Cond Res., 2009; 23(1): 51-7, PMID: 18824930
Keywords: Warm Up - Galileo vs. Cycling
Doc-ID: 1713,

Clinical Studies

Whole body vibration does not potentiate the stretch reflex

Whole body vibration (WBV) is theorized to enhance neural potentiation of the stretch reflex. The purpose of this study was to determine if WBV affects the quadriceps reflex from a patellar tendon tap. Subjects weiter...

Author: Hopkins JT, Fredericks D, Guyon PW, Parker S, Gage M, Feland JB, Hunter I
Source: Int J Sports Med., 2009; 30(2): 124-9, PMID: 18773376
Doc-ID: 1715,

Clinical Studies

Bone loss in the lower leg during 35 days of bed rest is predominantly from the cortical compartment

Immobilization-induced bone loss is usually greater in the epiphyses than in the diaphyses. The larger fraction of trabecular bone in the epiphyses than in the diaphyses offers an intuitive explanation to accou weiter...

Author: Rittweger J, Simunic B, Bilancio G, Gaspare De Santo N, Cirillo M, Biolo G, Pisot R, Eiken O, Mekjavic IB, Narici M
Source: Bone., 2009; PMID: 19168165
Keywords: BedRest
Doc-ID: 1716,

Clinical Studies

Tibial geometry in individuals with neurofibromatosis type 1 without anterolateral bowing of the lower leg using peripheral quantitative computed tomography

INTRODUCTION: Lower leg bowing with tibial pseudarthrosis is associated with neurofibromatosis type 1 (NF1). The objective of the study is to determine if the geometry of the lower limb in individuals with neur weiter...

Author: Stevenson DA, Viskochil DH, Carey JC, Slater H, Murray M, Sheng X, D"Astous J, Hanson H, Schorry E, Moyer-Mileur LJ
Source: Bone., 2008; PMID: 19118659
Doc-ID: 1722,

Clinical Studies

Serum Estradiol is Associated with Volumetric Bone Mineral Density and Modulates the Impact of Physical Activity on Bone Size at the Age of Peak Bone Mass; a Study in Healthy Male Siblings

Abstract Introduction: This study investigates determinants of peak bone mass (PBM) in healthy men, focusing on effects and interactions of parameters reflecting mechanical loading and sex steroids. Methods: He weiter...

Author: Lapauw B, Taes Y, Bogaert V, Vanbillemont G, Goemaere S, Zmierczak H, De Bacquer D, Kaufman J
Source: J Bone Miner Res., 2008; PMID: 19113912
Doc-ID: 1724,

Clinical Studies

Beta-adrenergic blockade and leptin replacement effectively mitigate disuse bone loss

Our objective was to test effects of beta-adrenergic blockade on hindlimb unloading (HU)-induced bone loss and serum leptin and to compare these responses with those observed with leptin replacement. Adult male weiter...

Author: Baek K, Bloomfield SA
Source: J Bone Miner Res., 2009; 24(5): 792-9, PMID: 19113907
Doc-ID: 1725,

Clinical Studies

A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6-19 years

We have produced paediatric reference data for forearm sites using the Stratec XCT-2000 peripheral quantitative computed tomography scanner. These data are intended for clinical and research use and will assist weiter...

Author: Ashby RL, Ward KA, Roberts SA, Edwards L, Mughal MZ, Adams JE
Source: Osteoporos Int., 2008; PMID: 19066709
Doc-ID: 1726,

Clinical Studies

Whole-body vibration dosage alters leg blood flow

The effect of whole-body vibration dosage on leg blood flow was investigated. Nine healthy young adult males completed a set of 14 random vibration and non-vibration exercise bouts whilst squatting on a Galileo weiter...

Author: Lythgo N, Eser P, de Groot P, Galea M
Source: Clin Physiol Funct Imaging., 2009; 29(1): 53-9, PMID: 19125731
Doc-ID: 1703,

Clinical Studies

Sprint and endurance power and ageing: an analysis of master athletic world records

Human physical performance is notably reduced with ageing. Although the effects of ageing are often compounded by disuse, the study of master athletes provides an opportunity for investigating the effects of ag weiter...

Author: Rittweger J, di Prampero PE, Maffulli N, Narici MV
Source: Proc Biol Sci., 2009; 276(1657): 683-9, PMID: 18957366
Doc-ID: 1773,

Clinical Studies

The effect of bed rest and an exercise countermeasure on leg venous function

This study was performed to assess the effect of resistive vibration exercise during bed rest deconditioning on venous vascular dimension and function, as measured with ultrasound in the popliteal vein. Sixteen weiter...

Author: van Duijnhoven NT, Bleeker MW, de Groot PC, Thijssen DH, Felsenberg D, Rittweger J, Hopman MT
Source: Eur J Appl Physiol., 2008; 104(6): 991-8, PMID: 18719936
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 1774,

Clinical Studies

Vertical jump performance after 90 days bed rest with and without flywheel resistive exercise, including a 180 days follow-up

Muscle atrophy and neuromuscular de-conditioning occur in response to space flight and bed-rest. In this study, we investigated the efficacy of flywheel training to conserve jumping power and height during 90 d weiter...

Author: Rittweger J, Felsenberg D, Maganaris C, Ferretti JL
Source: Eur J Appl Physiol., 2007; 100(4): 427-36, PMID: 17406887
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 1776,

Clinical Studies

Changes in Volumetric Bone Density and Strength at the Tibial Midshaft in Boys and Girls during Growth

Author: Ahamed Y, Cooper D ML, Burrows M, Braid S, McKay H
Source: ASBMR, 2008;
Keywords: Children
Doc-ID: 1772,
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Clinical Studies

Peripheral quantitative computed tomography of the proximal radius in young subjects - New reference data and interpretation of results

The aim of this contribution is to provide reference data for peripheral quantitative computed tomography (Stratec XCT2000(R)) performed at the proximal radius (the so-called "65% site") of young subjects and t weiter...

Author: Rauch F, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2008; 8(3): 217-26, PMID: 18799854
Keywords: Bone Geometry, Bone Mineral Density, Bone Size, Children, Peripheral Quantitative Computed Tomography
Doc-ID: 1689,
More information: Original Article

Clinical Studies

Muscle-bone relationships in the lower leg of healthy pre-pubertal females and males

Muscle-bone relationships in healthy pre-pubertal children were investigated using four muscle measures as predictors of tibial strength: 66% tibia cross-sectional muscle area (CSMA) by pQCT; leg lean mass (LLM weiter...

Author: Binkley TL, Specker BL
Source: J Musculoskelet Neuronal Interact., 2008; 8(3): 239-43, PMID: 18799856
Keywords: Muscle-bone, Pre-pubertal, pQCT, Cross-sectional Muscle Area, Bone Strength
Doc-ID: 1690,
More information: Original Article

Clinical Studies

Strength indices from pQCT imaging predict up to 85% of variance in bone failure properties at tibial epiphysis and diaphysis

Our primary objective was to validate the Bone Strength Index for compression (BSIC) by determining the amount of variance in failure load and stiffness that was explained by BSIC and bone properties at two dis weiter...

Author: Kontulainen SA, Johnston JD, Liu D, Leung C, Oxland TR, McKay HA
Source: J Musculoskelet Neuronal Interact., 2008; 8(4): 401-9, PMID: 19147978
Keywords: pQCT, Strength Indices, Failure Load, Stiffness, Moment, Flexural Rigidity tibia, strength index
Doc-ID: 1691,
More information: Original Article

Clinical Studies

The effects of high potassium consumption on bone mineral density in a prospective cohort study of elderly postmenopausal women

SUMMARY: Few studies have investigated the long-term effects of potassium intake on BMD. In a cohort of 266 elderly women, we found that baseline potassium intake as reflected by 24-hour urine potassium excreti weiter...

Author: Zhu K, Devine A, Prince RL
Source: Osteoporos Int., 2009; 20(2): 335-40, PMID: 18575949
Keywords: Bone mineral density . Dual energy x-ray absorptiometry . Elderly women . Peripheral quantitative computed tomography . Potassium . Trabecular bone
Doc-ID: 1695,

Clinical Studies

Bone mass and structure in adolescents with type 1 diabetes compared to healthy peers

SUMMARY: We measured bone mass and structure using pQCT and DXA in adolescents with Type 1 diabetes and compared the results with those of healthy peers. Our results showed that diabetes is associated with redu weiter...

Author: Saha MT, Sievänen H, Salo MK, Tulokas S, Saha HH
Source: Osteoporos Int., 2009; 20(8): 1401-6, PMID: 19083073
Keywords: Adolescence . Bone fragility . Bone mineral content . Osteoporosis . Type 1 diabetes
Doc-ID: 1696,

Clinical Studies

Asymmetric bone adaptations to soleus mechanical loading after spinal cord injury

The purpose of this report is to examine longitudinal bone mineral density (BMD) changes in individuals with spinal cord injury (SCI) who began unilateral soleus electrical stimulation early after injury. Twelv weiter...

Author: Dudley-Javoroski S, Shields RK
Source: J Musculoskelet Neuronal Interact., 2008; 8(3): 227-38, PMID: 18799855
Keywords: Spinal chord injury, bone adaptation, Peripheral Quantitative Computed Tomography, Electrical Stimulation, Compression, Tension
Doc-ID: 1697,
More information: Original Article

Clinical Studies

High-density surface EMG study on the time course of central nervous and peripheral neuromuscular changes during 8 weeks of bed rest with or without resistive vibration exercise

The aim of the present study was to assess the time course and the origin of adaptations in neuromuscular function as a consequence of prolonged bed rest with or without countermeasure. Twenty healthy males vol weiter...

Author: Mulder ER, Gerrits KH, Kleine BU, Rittweger J, Felsenberg D, de Haan A, Stegeman DF
Source: J Electromyogr Kinesiol., 2009; 19(2): 208-18, PMID: 17560125
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 1769,

Clinical Studies

Characteristics of fast voluntary and electrically evoked isometric knee extensions during 56 days of bed rest with and without exercise countermeasure

The contractile characteristics of fast voluntary and electrically evoked unilateral isometric knee extensions were followed in 16 healthy men during 56 days of horizontal bed rest and assessed at bed rest days weiter...

Author: Mulder ER, Gerrits KH, Rittweger J, Felsenberg D, Stegeman DF, de Haan A
Source: Eur J Appl Physiol., 2008; 103(4): 431-40, PMID: 18386049
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 1781,

Clinical Studies

Whole body vibration: a new therapeutic approach to improve muscle function in cystic fibrosis

Disease progression in cystic fibrosis (CF) leads to muscle wasting and loss of muscle function. The aim of this prospective pilot study was to evaluate the effects of whole body vibration (WBV) on muscle funct weiter...

Author: Rietschel E, van Koningsbruggen S, Fricke O, Semler O, Schoenau E
Source: Int J Rehabil Res., 2008; 31(3): 253-6, PMID: 18708849
Keywords: Köln
Doc-ID: 1786,

Clinical Studies

Contrast Agent-Enhanced Computed Tomography of Articular Cartilage: Association with Tissue Composition and Properties

Background: Contrast agent-enhanced computed tomography may enable the noninvasive quantification of glycosaminoglycan (GAG) content of articular cartilage. It has been reported that penetration of the negative weiter...

Author: Silvast TS, Jurvelin JS, Aula AS, Lammi MJ, Toyras J
Source: Acta Radiol., 2008; PMID: 19052932
Doc-ID: 1666,

Clinical Studies

Divergent Effects of Glucocorticoids on Cortical and Trabecular Compartment Bone Mineral Density in Childhood Nephrotic Syndrome

Abstract Glucocorticoid (GC) effects on skeletal development have not been established. The objective of this peripheral quantitative computed tomography (pQCT) study was to assess volumetric bone mineral densi weiter...

Author: Wetzsteon RJ, Shults J, Zemel BS, Gupta PU, Burnham JM, Herskovitz RM, Howard KM, Leonard MB
Source: J Bone Miner Res., 2009; 24(3):: 503-13, PMID: 19016583
Doc-ID: 1669,

Clinical Studies

Longitudinal Assessment of Bone Density and Structure in an Incident Cohort of Children With Crohn"s Disease

BACKGROUND & AIMS: The impact of childhood Crohn"s disease (CD) and its therapies on volumetric bone mineral density (vBMD), bone structure, and muscle mass have not been established. The objective of this long weiter...

Author: Dubner SE, Shults J, Baldassano RN, Zemel BS, Thayu M, Burnham JM, Herskovitz RM, Howard KM, Leonard MB
Source: Gastroenterology., 2009; 136: 123-130, PMID: 19026647
Keywords: bone geometry, Crohn, muscle children bone geometry
Doc-ID: 1670,

Clinical Studies

Vitamin D status and muscle function in post-menarchal adolescent girls

Context: There has been a resurgence of vitamin D deficiency among infants, toddlers and adolescents in the United Kingdom. Myopathy is an important clinical symptom of vitamin D deficiency, yet it has not been weiter...

Author: Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, Mughal Z
Source: J Clin Endocrinol Metab., 2009; 94(2): 559-563, PMID: 19033372
Doc-ID: 1674,

Clinical Studies

The effect of L-arginine administration on muscle force and power in postmenopausal women

Previously published data (J Bone Miner Res (2005); 20: 471) did not give evidence that the administration of the nitric oxide precursor L-arginine increases bone formation and decreases bone resorption in post weiter...

Author: Fricke O, Baecker N, Heer M, Tutlewski B, Schoenau E
Source: Clin Physiol Funct Imaging., 2008; 28(5): 307-11, PMID: 18510549
Keywords: cross-sectional muscle area; L-arginine; maximal isometric grip force; nitric oxide; peak jump force; peak jump power
Doc-ID: 1675,

Clinical Studies

Musculoskeletal plasticity after acute spinal cord injury: effects of long-term neuromuscular electrical stimulation training

Maintaining the physiologic integrity of paralyzed limbs may be critical for those with spinal cord injury (SCI) to be viable candidates for a future cure. No long-term intervention has been tested to attempt t weiter...

Author: Shields RK, Dudley-Javoroski S
Source: J Neurophysiol., 2006; 95(4): 2380-90, PMID: 16407424
Keywords: spinal chord injury electrical stimulation
Doc-ID: 1676,

Clinical Studies

Vibrationstraining mit Gonarthrosepatienten

Formen der funktionellen Belastung sind eine wichtige therapeutische Maßnahme in der Therapie von Gonarthrosepatienten. Ziel dieser Studie war es, zu überprüfen, welche Effektivität ein Vibrationstraining weiter...

Author: Rapp W, Albrich C, Horstmann T, Heitkamp HC
Source: 40. Deutscher Sportärzte Kongress, 2007;
Keywords: Vibrationstraining, Gonarthrose, Krafttraining
Doc-ID: 1657,
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Clinical Studies

Anterior-posterior bending strength at the tibial shaft increases with physical activity in boys: evidence for non-uniform geometric adaptation

We investigated bone structural adaptations to a 16-month school-based physical activity intervention in 202 young boys using a novel analytical method for peripheral quantitative computed tomography scans of t weiter...

Author: Macdonald HM, Cooper DM, McKay HA
Source: Osteoporos Int., 2009; 20(1): 61-70, PMID: 18496638
Keywords: Bone . Children . Peripheral QCT. Physical activity, bone geometry
Doc-ID: 1653,

Clinical Studies

Bone structure and volumetric BMD in overweight children: a longitudinal study

The effect of excess body fat on bone strength accrual is not well understood. Therefore, we assessed bone measures in healthy weight (HW) and overweight (OW) children. Children (9-11 yr) were classified as HW weiter...

Author: Wetzsteon RJ, Petit MA, Macdonald HM, Hughes JM, Beck TJ, McKay HA
Source: J Bone Miner Res., 2008; 23(12): 1946-53, PMID: 18684083
Doc-ID: 1655,

Clinical Studies

Veränderungen der Knochenstruktur der Tibia, quantifiziert mit der pQCT, bei kleinwüchsigen Kindern und Jugendlichen unter Therapie mit Wachstumshormon

Als Prädiktoren für das Wachstum unter WH-Therapie werden auxiologische und laborchemische Parameter eingesetzt. Diese prospektive Studie evaluiert die Knochenstruktur der Tibia vor und während einer Therapi weiter...

Author: THOMAS SCHWAB
Source: Dissertation, 2003;
Keywords: children bone geometry, growth hormone
Doc-ID: 1597,
More information: Original Article

Clinical Studies

Comparative assessment of bone mineral measurements using dual X-ray absorptiometry and peripheral quantitative computed tomography

A measurement of bone mass is the single most important determinant of future fracture. However, controversy exists as to which technique (dual X-ray absorptiometry (DXA) or peripheral quantitative computed tom weiter...

Author: Formica CA, Nieves JW, Cosman F, Garrett P, Lindsay R
Source: Osteoporos Int., 1998; 8(5): 460-7, PMID: 9850355
Keywords: Bone densitometry; Bone mineral density; Dual X-ray absorptiometry; Peripheral quantitative computed tomography
Doc-ID: 1615,

Clinical Studies

Epidemiology of falls

Author: Masud T, Morris RO
Source: Age Ageing., 2001; 30 Suppl 4: 3-7, PMID: 11769786
Doc-ID: 1617,
More information: Original Article

Clinical Studies

The impact of degenerative spinal changes on the correlation of peripheral and axial bone density

Results of bone density measurements by quantitative computed tomography of the peripheral skeleton (pQCT) were compared with those of measurements at the axial skeleton with a view to study the effects of dege weiter...

Author: Schneider P, Börner W
Source: Nuklearmedizin., 1994; 33(4): 138-43, PMID: 7971288
Keywords: comparison axial peripheral bone density sensitivity
Doc-ID: 1636,

Clinical Studies

Impact on bone of an estrogen receptor-alpha gene loss of function mutation

CONTEXT: The kindred described is the only known instance of a germ line loss of function mutation of estrogen receptor (ER)-alpha. OBJECTIVE: Our objective was to assess the impact of a loss of function mutati weiter...

Author: Smith EP, Specker B, Bachrach BE, Kimbro KS, Li XJ, Young MF, Fedarko NS, Abuzzahab MJ, Frank GR, Cohen RM, Lubahn DB, Korach KS
Source: J Clin Endocrinol Metab., 2008; 93(8): 3088-96, PMID: 18505767
Keywords: estrogen receptor gene
Doc-ID: 1571,

Clinical Studies

Skeletal effects of estrogen and mechanical loading are structurally distinct

Estrogen has been suggested to influence skeletal homeostasis by both increasing the sensitivity of the feedback control system for skeletal rigidity and acting directly on bone surfaces. The objective of the p weiter...

Author: Pajamäki I, Sievänen H, Kannus P, Jokihaara J, Vuohelainen T, Järvinen TL
Source: Bone., 2008; 43(4): 748-57, PMID: 18620089
Keywords: estrogen, mechanical loading, loading sensitivity
Doc-ID: 1575,

Clinical Studies

Bone steady-state is established at reduced bone strength after spinal cord injury: a longitudinal study using peripheral quantitative computed tomography (pQCT)

Spinal cord injury (SCI) is associated with a marked and rapid sublesional bone loss. So far, reports about the time course of adaptive changes in bone mass and structure in people with chronic and complete SCI weiter...

Author: Frotzler A, Berger M, Knecht H, Eser P
Source: Bone., 2008; 43(3): 549-55, PMID: 18567554
Keywords: spinal chord injury bone strength
Doc-ID: 1577,

Clinical Studies

Muscle power is related to tibial bone strength in older women

We enrolled 65 to 75 year-old community-dwelling women and measured muscle power, strength, physical activity using accelerometry and tibial bone strength using peripheral quantitative computed tomography (pQCT weiter...

Author: Ashe MC, Liu-Ambrose TY, Cooper DM, Khan KM, McKay HA
Source: Osteoporos Int., 2008; 19(12): 1725-32, PMID: 18629571
Keywords: Accelerometry. Bone strength . Muscle power . Muscle strength . pQCT, BBR, Berlin Bedrest Study
Doc-ID: 1563,

Clinical Studies

The effect of menarcheal age on anthropometric, limb length, and bone measures in Hutterite and non-Hutterite women

The age women reach menarche may affect bone length and mass. Some studies show an earlier menarcheal age (MA) results in a shorter stature and increased body fat. We hypothesized that Hutterite women have a sh weiter...

Author: Grimsrud C, Binkley T, Specker B
Source: Am J Hum Biol., 2008; 20(6): 693-9, PMID: 18491408
Doc-ID: 1565,

Clinical Studies

Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions

The International Society for Clinical Densitometry (ISCD) has developed Official Positions for the clinical use of dual-energy X-ray absorptiometry (DXA) and non-DXA technologies. While only DXA can be used fo weiter...

Author: Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg D, Ito M, Prevrhal S, Hans DB, Lewiecki EM
Source: J Clin Densitom., 2008; 11(1): 123-62, PMID: 18442757
Doc-ID: 1537,

Clinical Studies

Tibial bone geometry in chronic stroke patients: influence of sex, cardiovascular health, and muscle mass

This study aimed to examine the geometry of the tibia in chronic stroke survivors. Fifty-five ambulatory individuals with chronic stroke were included in the study. pQCT was used to obtain a cross-sectional sca weiter...

Author: Pang MY, Ashe MC, Eng JJ
Source: J Bone Miner Res., 2008; 23(7): 1023-30, PMID: 18302505
Keywords: bone geometry, heart disease, muscle
Doc-ID: 1543,

Clinical Studies

Characterising cortical density in the mid-tibia: intra-individual variation in adolescent girls and boys

BACKGROUND: Inter-individual differences in cortical bone volumetric density (CoD), such as those related to sex, are a product of differences in remodelling rates. While cortical bone is often treated as a uni weiter...

Author: Cooper DM, Ahamed Y, Macdonald HM, McKay HA
Source: Br J Sports Med., 2008; 42(8): 690-5, PMID: 18635740
Keywords: Children, adolescents, cortical density
Doc-ID: 1547,

Clinical Studies

Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits

OBJECTIVE: To identify determinants of musculoskeletal deficits (muscle cross-sectional area [mCSA], trabecular volumetric bone mineral density [vBMD], and cortical bone strength [section modulus]) in patients weiter...

Author: Burnham JM, Shults J, Dubner SE, Sembhi H, Zemel BS, Leonard MB
Source: Arthritis Rheum., 2008; 58(8): 2518-27, PMID: 18668565
Doc-ID: 1548,

Clinical Studies

BMD and bone geometry in transtibial and transfemoral amputees

Prolonged unloading of bone(s) in the residual limb after amputation may cause significant bone loss in the hip and distal bony end of the residual limb. The purpose of this study was to examine the effect of a weiter...

Author: Sherk VD, Bemben MG, Bemben DA
Source: J Bone Miner Res., 2008; 23(9): 1449-57, PMID: 18410229
Doc-ID: 1550,

Clinical Studies

Improved peripheral cortical bone geometry after surgical treatment of primary hyperparathyroidism in postmenopausal women

CONTEXT: Cortical bone geometry is one of the most important components of bone strength. Excess endogenous PTH or intermittent PTH administration affects cortical bone geometry; however, the changes in cortica weiter...

Author: Kaji H, Yamauchi M, Nomura R, Sugimoto T
Source: J Clin Endocrinol Metab., 2008; 93(8): 3045-50, PMID: 18544624
Keywords: bone geometry, pth primary hyperparathyreoidism
Doc-ID: 1553,

Clinical Studies

Tibial subchondral trabecular volumetric bone density in medial knee joint osteoarthritis using peripheral quantitative computed tomography technology

OBJECTIVE: Knee osteoarthritis (OA) is an organ-level failure of the joint involving pathologic changes in articular cartilage and bone. This cross-sectional study compared apparent volumetric bone mineral dens weiter...

Author: Bennell KL, Creaby MW, Wrigley TV, Hunter DJ
Source: Arthritis Rheum., 2008; 58(9): 2776-85, PMID: 18759296
Doc-ID: 1554,

Clinical Studies

20-Hz whole body vibration training fails to counteract the decrease in leg muscle volume caused by 14 days of 6 degrees head down tilt bed rest

A 6 degrees head down tilt bed rest (HDT) was used to simulate the effects of muscle unloading in space. We tested whether vibration training (VT) reduces the decrease in leg muscle volume induced by 14 days HD weiter...

Author: Zange J, Mester J, Heer M, Kluge G, Liphardt AM
Source: Eur J Appl Physiol., 2008; PMID: 18972127
Doc-ID: 1558,

Clinical Studies

Mechanographic characteristics of adolescents and young adults with congenital heart disease

The present study comprised 29 adolescents and young adults (15 females, 14 males; aged 14.1-23.9 years) with congenital heart disease (CHD) and focused on the interaction between the biomechanical system and C weiter...

Author: Fricke O, Witzel C, Schickendantz S, Sreeram N, Brockmeier K, Schoenau E
Source: Eur J Pediatr., 2008; 167(3): 331-6, PMID: 17516086
Doc-ID: 1559,

Clinical Studies

Differences in physical fitness of male and female recruits in gender-integrated army basic training

PURPOSE: To evaluate gender differences in physical fitness before and after a 4-month gender-integrated basic training (BT) course and to determine whether this program effectively narrowed the differences bet weiter...

Author: Yanovich R, Evans R, Israeli E, Constantini N, Sharvit N, Merkel D, Epstein Y, Moran DS
Source: Med Sci Sports Exerc., 2008; 40(11 Suppl): S654-9, PMID: 18849869
Doc-ID: 1562,

Clinical Studies

Long-bone changes after pamidronate discontinuation in children and adolescents with osteogenesis imperfecta

Cyclical intravenous pamidronate is a widely used symptomatic therapy in moderate to severe osteogenesis imperfecta (OI). The effects of treatment discontinuation on long bone development have not been characte weiter...

Author: Rauch F, Cornibert S, Cheung M, Glorieux FH
Source: Bone., 2007; 40(4): 821-7, PMID: 17223617
Keywords: bisphosphonates, children, adolescents, osteogenesis imperfecta
Doc-ID: 1532,

Clinical Studies

Bone Volumetric Density, Geometry and Strength in Female and Male Collegiate Runners

Author: Thiescafer AJ, Hughes JM, Popp KL, Wetzsteon RJ, Stovitz SD, Kaufman BC, Kurzer MS, Petit MA
Source: ASBMR, 2008;
Doc-ID: 1533,
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Clinical Studies

Jumping Mechanography Safely Evaluates Muscle Performance in Older Adults

Neuromuscular function declines with advancing age and is strongly associated with increased risk for falls, hip fractures and decreased quality of life. A variety of tests, e.g., chair-rise or timed-up-and-go, weiter...

Author: Buehring B, Valentine S, Woods A, Checovich M, Krueger D, Binkley N
Source: ASBMR 2008, 2008;
Doc-ID: 1529,
Download:

Clinical Studies

Follicle-stimulating hormone does not impact male bone mass in vivo or human male osteoclasts in vitro.

Bone loss in the elderly is mainly caused by osteoclast-induced bone resorption thought to be causally linked to the decline in estrogen and testosterone levels in females and males. Recently, involvement of fo weiter...

Author: Ritter V, Thuering B, Saint Mezard P, Luong-Nguyen NH, Seltenmeyer Y, Junker U, Fournier B, Susa M, Morvan F.
Source: Calcif Tissue Int., 2008; 82: 383-91, PMID: 0018465073
Keywords: hormones, osteoclasts
Doc-ID: 1504,

Clinical Studies

Imaging of lower extremity stress fracture injuries

Stress reactions and stress fractures in the lower extremities occur frequently in military and athletic populations. As the clinical symptoms of stress fracture may mimic other less severe musculoskeletal inju weiter...

Author: Moran DS, Evans RK, Hadad E
Source: Sports Med., 2008; 38(4): 345-56, PMID: 18348592
Keywords: fatigue
Doc-ID: 1505,

Clinical Studies

Longitudinal changes in BMD and bone geometry in a population-based study

We prospectively examined vBMD and structural bone parameters assessed by QCT among participants of the InCHIANTI study over a 6-yr follow-up. Periosteal apposition occurred both in men and women. Endocortical weiter...

Author: Lauretani F, Bandinelli S, Griswold ME, Maggio M, Semba R, Guralnik JM, Ferrucci L
Source: J Bone Miner Res., 2008; 23(3): 400-8, PMID: 17997708
Keywords: longitudinal study, osteoporosis, periosteal apposition, endocortical resorption, BMD, bone geometry
Doc-ID: 1506,

Clinical Studies

Leisure physical activity and the risk of fracture in men

BACKGROUND: Data from previous studies are inconsistent, and it is therefore uncertain whether, to what extent, and at what level leisure physical activity influences the risk of osteoporotic fractures in men. weiter...

Author: Michaëlsson K, Olofsson H, Jensevik K, Larsson S, Mallmin H, Berglund L, Vessby B, Melhus H
Source: PLoS Med., 2007; 4(6): e199, PMID: 17579509
Keywords: fracture risk
Doc-ID: 1507,
More information: Original Article

Clinical Studies

Methods for measurement of pediatric bone

Many experts believe that optimizing bone mineral accrual early in life may prevent childhood fractures and possibly delay the development of osteoporosis later in life. Adequate nutrition and physical activity weiter...

Author: Binkley TL, Berry R, Specker BL
Source: Rev Endocr Metab Disord., 2008; 9(2): 95-106, PMID: 18247119
Keywords: Pediatrics . pQCT. DXA . Ultrasound . Bone density . Bone geometry, children
Doc-ID: 1508,

Clinical Studies

Genetic and environmental influence on structural strength of weight-bearing and non-weight-bearing bone: a twin study

A bivariate genetic analysis among 217 older female twin pairs showed that, although the structural strength of tibia and radius are mainly regulated by same genetic and environmental factors, the tibia is more weiter...

Author: Mikkola TM, Sipilä S, Rantanen T, Sievänen H, Suominen H, Kaprio J, Koskenvuo M, Kauppinen M, Heinonen A
Source: J Bone Miner Res., 2008; 23(4): 492-8, PMID: 18072876
Keywords: twins, genetics, bone geometry
Doc-ID: 1510,

Clinical Studies

In vivo magnetic resonance detects rapid remodeling changes in the topology of the trabecular bone network after menopause and the protective effect of estradiol

INTRODUCTION: Estrogen depletion after menopause is accompanied by bone loss and architectural deterioration of trabecular bone. The hypothesis underlying this work is that the microMRI-based virtual bone biops weiter...

Author: Wehrli FW, Ladinsky GA, Jones C, Benito M, Magland J, Vasilic B, Popescu AM, Zemel B, Cucchiara AJ, Wright AC, Song HK, Saha PK, Peachey H, Snyder PJ
Source: J Bone Miner Res., 2008; 23(5): 730-40, PMID: 18251704
Keywords: MRI, bone structure, estrogen
Doc-ID: 1511,

Clinical Studies

Subcutaneous Fat and Body Fat Mass Have Different Effects on Bone Development at the Forearm in Children and Adolescents

The present study investigated whether subcutaneous fat differs in the impact on bone development from fat mass (FM). We analyzed 295 healthy children and adolescents (age 5-19 years, 139 males) for FM by measu weiter...

Author: Fricke O, Land C, Semler O, Tutlewski B, Stabrey A, Remer T, Schoenau E
Source: Calcif Tissue Int., 2008; PMID: 18521529
Keywords: children, fat, adolescents
Doc-ID: 1513,

Clinical Studies

Muscle function improves during growth hormone therapy in short children born small for gestational age: results of a peripheral quantitative computed tomography study on body composition

BACKGROUND: Short small for gestational age (SGA) children can be affected by a lack of muscle mass rather than fat mass. They also face a high risk of the metabolic syndrome developing after childhood. It is n weiter...

Author: Schweizer R, Martin DD, Schönau E, Ranke MB
Source: J Clin Endocrinol Metab., 2008; 93(8): 2978-83, PMID: 18505766
Keywords: muscle groth hormone, growth retardation
Doc-ID: 1515,

Clinical Studies

Comparison of the skeletal effects of the progestogens desogestrel and levonorgestrel in oral contraceptive preparations in young women: controlled, open, partly randomized investigation over 13 cycles

AIM: This 12-month study was conducted to evaluate the skeletal effects of two monophasic oral contraceptives containing 20 mug of ethinylestradiol and 100 mug of levonorgestrel (LEVO) or 150 mug of desogestrel weiter...

Author: Hartard M, Kleinmond C, Luppa P, Zelger O, Egger K, Wiseman M, Weissenbacher ER, Felsenberg D, Erben RG
Source: Contraception., 2006; 74(5): 367-75, PMID: 17046377
Doc-ID: 1516,

Clinical Studies

The Response of Elderly Female fast Gait to Whole Body Vibration

Older adults walk more slowly than healthy young adults at fast and normal walking speeds. These age-associated changes in mobility impact upon daily function. A slower gait, for example, may reduce the older a weiter...

Author: Lorentzen HC
Source: PhD, 2007;
Keywords: Galileo (Eigenbau)
Doc-ID: 1443,

Clinical Studies

Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD

In postmenopausal women with a wide range of vertebral deformities, MRI-based structural measures of topology and scale at the distal radius are shown to account for as much as 30% of vertebral deformity, indep weiter...

Author: Ladinsky GA, Vasilic B, Popescu AM, Wald M, Zemel BS, Snyder PJ, Loh L, Song HK, Saha PK, Wright AC, Wehrli FW
Source: J Bone Miner Res., 2008; 23(1): 64-74, PMID: 17784842
Doc-ID: 1373,

Clinical Studies

High-volume FES-cycling partially reverses bone loss in people with chronic spinal cord injury

Spinal cord injury (SCI) leads to severe bone loss in the paralysed limbs and to a resulting increased fracture risk thereof. Since long bone fractures can lead to comorbidities and a reduction in quality of li weiter...

Author: Frotzler A, Coupaud S, Perret C, Kakebeeke TH, Hunt KJ, Donaldson Nde N, Eser P
Source: Bone., 2008; 43(1): 169-76, PMID: 18440891
Doc-ID: 1374,

Clinical Studies

Peripheral quantitative computed tomography in children and adolescents: the 2007 ISCD Pediatric Official Positions

Peripheral quantitative computed tomography (pQCT) has mainly been used as a research tool in children. To evaluate the clinical utility of pQCT and formulate recommendations for its use in children, the Intern weiter...

Author: Zemel B, Bass S, Binkley T, Ducher G, Macdonald H, McKay H, Moyer-Mileur L, Shepherd J, Specker B, Ward K, Hans D
Source: J Clin Densitom., 2008; 11(1): 59-74, PMID: 18442753
Doc-ID: 1375,

Clinical Studies

Glucocorticoid excess affects cortical bone geometry in premenopausal, but not postmenopausal, women

Glucocorticoid (GC) excess causes a great increase in fracture risk, but the effects of GC excess on cortical bone geometry are unknown. The present study was performed to examine the effects of GC excess on co weiter...

Author: Kaji H, Yamauchi M, Chihara K, Sugimoto T
Source: Calcif Tissue Int., 2008; 82(3): 182-90, PMID: 18278571
Keywords: cortisone, bone geometry
Doc-ID: 1376,

Clinical Studies

Relationship between endogenous parathyroid hormone and bone metabolism/geometry in female patients treated with glucocorticoid

Although the role of PTH (parathyroid hormone) has been debated in glucocorticoid (GC)-induced osteoporosis (GIO), clinical data about the relation of endogenous PTH to bone metabolism in patients treated with weiter...

Author: Kaji H, Yamauchi M, Chihara K, Sugimoto T
Source: Horm Metab Res., 2008; 40(1): 60-5, PMID: 18072075
Keywords: pth, cortisone, hormone
Doc-ID: 1377,

Clinical Studies

Fat Infiltration in Muscle: New Evidence for Familial Clustering and Associations With Diabetes

Objective:Increased fat infiltration in skeletal muscle has been associated with diabetes. Quantitative computed tomography (QCT) can be used to measure muscle density, which reflects the lipid content of skele weiter...

Author: Miljkovic-Gacic I, Wang X, Kammerer CM, Gordon CL, Bunker CH, Kuller LH, Patrick AL, Wheeler VW, Evans RW, Zmuda JM
Source: Obesity (Silver Spring)., 2008; PMID: 18535552
Keywords: fat, muscle
Doc-ID: 1378,

Clinical Studies

Bone size normalizes with age in children and adolescents with type 1 diabetes

OBJECTIVE: The aim of this study was to establish whether type 1 diabetes has a long-term effect on bone development in children and adolescents. RESEARCH DESIGN AND METHODS: Bone characteristics and muscle cro weiter...

Author: Bechtold S, Putzker S, Bonfig W, Fuchs O, Dirlenbach I, Schwarz HP
Source: Diabetes Care., 2007; 30(8): 2046-50, PMID: 17456838
Keywords: children, adolescents, bone geometry, diabetes
Doc-ID: 1379,

Clinical Studies

Effects of Depot medroxyprogesterone acetate on bone density and bone metabolism before and after peak bone mass: a case-control study

INTRODUCTION: Depot medroxyprogesterone acetate (DMPA; Depo-Provera, Tadworth, UK) contraception is used by more than 9 million women worldwide and has a high usage among teenagers in the United Kingdom and the weiter...

Author: Walsh JS, Eastell R, Peel NF
Source: J Clin Endocrinol Metab., 2008; 93(4): 1317-23, PMID: 18230659
Keywords: Estrogen, hormones
Doc-ID: 1380,

Clinical Studies

Osteoporosis in men

With the aging of the population, there is a growing recognition that osteoporosis and fractures in men are a significant public health problem, and both hip and vertebral fractures are associated with increase weiter...

Author: Khosla S, Amin S, Orwoll E
Source: Endocr Rev., 2008; 29(4): 441-64, PMID: 18451258
Doc-ID: 1381,

Clinical Studies

Whole body vibration in cystic fibrosis - a pilot study

Introduction: In cystic fibrosis (CF), bone mass deficits as well as a lack of muscle mass and force have been described. The bone mass deficits are thought to be at least in part secondary to the reduced muscl weiter...

Author: Roth J, Wust M, Rawer R, Schnabel D, Armbrecht G, Beller G, Rembitzki I, Wahn U, Felsenberg D, Staab D
Source: J Musculoskelet Neuronal Interact., 2008; 8(2): 179-87, PMID: 18622087
Keywords: Cystic Fibrosis, Whole Body Vibration, Bone, Muscle, Osteoporosis
Doc-ID: 1382,
More information: Original Article

Clinical Studies

Results of a prospective pilot trial on mobility after whole body vibration in children and adolescents with osteogenesis imperfecta

OBJECTIVE: To evaluate the effect of whole body vibration on the mobility of long-term immobilized children and adolescents with a severe form of osteogenesis imperfecta. Osteogenesis imperfecta is a hereditary weiter...

Author: Semler O, Fricke O, Vezyroglou K, Stark C, Stabrey A, Schoenau E
Source: Clin Rehabil., 2008; 22(5): 387-94, PMID: 18441035
Keywords: Köln
Doc-ID: 1365,

Clinical Studies

Decline of specific peak jumping power with age in master runners

Background: It is difficult to disentangle the effects of pure ageing from those of disuse. Master athletes, however, provide an opportunity to assess the effects of ageing per se, as these people maintain high weiter...

Author: Michaelis I, Kwiet A, Gast U, Boshof A, Antvorskov T, Jung T, Rittweger J, Felsenberg D
Source: J Musculoskelet Neuronal Interact., 2008; 8(1): 64-70, PMID: 18398267
Keywords: Power
Doc-ID: 1309,
More information: Original Article

Clinical Studies

The rate of muscle temperature increase during acute whole-body vibration exercise

This study compared the rate of muscle temperature (T (m)) increase during acute whole-body vibration (WBV), to that of stationary cycling and passive warm-up. Additionally we wanted to determine if the purport weiter...

Author: Cochrane DJ, Stannard SR, Sargeant AJ, Rittweger J
Source: Eur J Appl Physiol., 2008; 103(4): 441-8, PMID: 18392845
Keywords: Muscle Temperature Power
Doc-ID: 1310,

Clinical Studies

Impact of parathyroid status and Ca and vitamin-D supplementation on bone mass and muscle-bone relationships in 208 Belarussian children after thyroidectomy because of thyroid carcinoma

This observational study analyzes Ca-P metabolism and its impact on bone mass accrual and density and the muscle-bone mass/mass relationships in male and female children and adolescents who were parathyroidecto weiter...

Author: Schneider P, Biko J, Reiners C, Demidchik YE, Drozd VM, Capozza RF, Cointry GR, Ferretti JL
Source: Exp Clin Endocrinol Diabetes., 2004; 112(8): 444-50, PMID: 15372365
Keywords: TBMC vs. TLM
Doc-ID: 1291,

Clinical Studies

Resistive simulated weightbearing exercise with whole body vibration reduces lumbar spine deconditioning in bed-rest.

STUDY DESIGN: Randomized controlled trial. OBJECTIVE: Determine the effectiveness a resistive exercise countermeasure with whole-body vibration in relation to lumbo-pelvic muscle and spinal morphology changes d weiter...

Author: Belavý DL, Hides JA, Wilson SJ, Stanton W, Dimeo FC, Rittweger J, Felsenberg D, Richardson CA.
Source: Spine., 2008; 33(5): E121-31, PMID: 18317179
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 1286,

Clinical Studies

Whole body vibration versus conventional physiotherapy to improve balance and gait in Parkinson"s disease.

OBJECTIVE: To compare the effects of whole body vibration (WBV) and conventional physiotherapy (PT) on levodopa-resistant disturbances of balance and gait in idiopathic Parkinson"s disease (PD). DESIGN: weiter...

Author: Ebersbach G, Edler D, Kaufhold O, Wissel J.
Source: Arch Phys Med Rehabil., 2008; 89(3): 399-403, PMID: 18295614
Keywords: Parkinson
Doc-ID: 1285,

Clinical Studies

Males have larger skeletal size and bone mass than females, despite comparable body size

Gender differences in fractures may be related to body size, bone size, geometry, or density. We studied this in 18-year-old males (n = 36) and females (n = 36) matched for height and weight. Despite comparable weiter...

Author: Nieves JW, Formica C, Ruffing J, Zion M, Garrett P, Lindsay R, Cosman F
Source: J Bone Miner Res., 2005; 20(3): 529-35, PMID: 15746999
Doc-ID: 1246,

Clinical Studies

Growth patterns at distal radius and tibial shaft in pubertal girls: a 2-year longitudinal study

Bone changes, in terms of both size and BMD, were assessed longitudinally in pubertal girls. Before puberty, BMD at the distal radius declined, whereas bone size increased, suggesting that normal growing girls weiter...

Author: Wang Q, Alén M, Nicholson P, Lyytikäinen A, Suuriniemi M, Helkala E, Suominen H, Cheng S
Source: J Bone Miner Res., 2005; 20(6): 954-61, PMID: 15883635
Doc-ID: 1248,

Clinical Studies

Examining bone surfaces across puberty: a 20-month pQCT trial

This follow-up study assessed sex differences in cortical bone growth at the tibial midshaft across puberty. In both sexes, periosteal apposition dominated over endosteal resorption. Boys had a greater magnitud weiter...

Author: Kontulainen SA, Macdonald HM, Khan KM, McKay HA
Source: J Bone Miner Res., 2005; 20(7): 1202-7, PMID: 15940373
Doc-ID: 1249,

Clinical Studies

Age of attainment of peak bone mass is site specific in Swedish men--The GOOD study

Results from this study suggest that PBM has been attained in the spine and femoral neck, but not in the radius or tibia, in 18- to 20-year-old men, in which an endosteal contraction and increase in cortical vo weiter...

Author: Lorentzon M, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2005; 20(7): 1223-7, PMID: 15940376
Doc-ID: 1250,

Clinical Studies

Polymorphisms in the aromatase gene predict areal BMD as a result of affected cortical bone size: the GOOD study

The association between aromatase gene polymorphisms, bone parameters, and sex steroid levels was studied in 1068 men (18.9 +/- 0.6 years of age). Several aromatase gene polymorphisms were found to be associate weiter...

Author: Lorentzon M, Swanson C, Eriksson AL, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2006; 21(2): 332-9, PMID: 16418790
Doc-ID: 1251,

Clinical Studies

Leptin is a negative independent predictor of areal BMD and cortical bone size in young adult Swedish men

The association between leptin and areal BMD has been controversial, and the predictive role of leptin on cortical volumetric BMD and bone size has not previously been studied. We show that leptin is a negative weiter...

Author: Lorentzon M, Landin K, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2006; 21(12): 1871-8, PMID: 17002557
Doc-ID: 1252,

Clinical Studies

Is a school-based physical activity intervention effective for increasing tibial bone strength in boys and girls

This 16-month randomized, controlled school-based study compared change in tibial bone strength between 281 boys and girls participating in a daily program of physical activity (Action Schools! BC) and 129 same weiter...

Author: Macdonald HM, Kontulainen SA, Khan KM, McKay HA
Source: J Bone Miner Res., 2007; 22(3): 434-46, PMID: 17181400
Doc-ID: 1253,

Clinical Studies

Genetic and environmental determinants of volumetric and areal BMD in multi-generational families of African ancestry: the Tobago Family Health Study

BMD is higher and fracture risk is lower among individuals of African versus European descent, but little is known about the genetic architecture of BMD in the former group. Heritabilities of areal and volumetr weiter...

Author: Wang X, Kammerer CM, Wheeler VW, Patrick AL, Bunker CH, Zmuda JM
Source: J Bone Miner Res., 2007; 22(4): 527-36, PMID: 17227221
Doc-ID: 1254,

Clinical Studies

Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y)

CONTEXT: Sex steroids are involved in the regulation of pubertal cortical bone expansion in males. In vitro studies have indicated that the enzyme uridine diphosphate glucuronosyltransferase (UGT) 2B7 has the c weiter...

Author: Swanson C, Lorentzon M, Vandenput L, Labrie F, Rane A, Jakobsson J, Chouinard S, Bélanger A, Ohlsson C
Source: J Clin Endocrinol Metab., 2007; 92(9): 3697-704, PMID: 17579197
Doc-ID: 1255,

Clinical Studies

Growth in early life predicts bone strength in late adulthood: the Hertfordshire Cohort Study

Infant growth is a determinant of adult bone mass, and poor childhood growth is a risk factor for adult hip fracture. Peripheral quantitative computed tomography (pQCT) allows non-invasive assessment of bone st weiter...

Author: Oliver H, Jameson KA, Sayer AA, Cooper C, Dennison EM, Hertfordshire Cohort Study Group
Source: Bone., 2007; 41(3): 400-5, PMID: 17599849
Doc-ID: 1256,

Clinical Studies

Relationship of volumetric bone mineral density and structural parameters with ERalpha gene polymorphisms

Bone mineral density (BMD) contributes to bone strength, and methods for clinical assessment of bone quality characteristics beyond what can be gathered by BMD are awaited. Peripheral quantitative computed tomo weiter...

Author: Cepollaro C, Lauretani F, Gozzini A, Masi L, Falchetti A, Del Monte F, Carbonell-Sala S, Tanini A, Corsi AM, Bandinelli S, Ferrucci L, Brandi ML
Source: Calcif Tissue Int., 2007; 80(5): 307-15, PMID: 17505773
Doc-ID: 1259,

Clinical Studies

Forearm bone geometry and mineral content in UK women of European and South-Asian origin

Ethnic variation in areal bone mineral density (BMD) has been well documented. Such variation may, however, reflects differences in bone geometry rather than volumetric BMD (vBMD). The aim of the study was to c weiter...

Author: Ward KA, Roy DK, Pye SR, O"Neill TW, Berry JL, Swarbrick CM, Silman AJ, Adams JE
Source: Bone., 2007; 41(1): 117-21, PMID: 17493888
Doc-ID: 1260,

Clinical Studies

Material matters: a mechanostat-based perspective on bone development in osteogenesis imperfecta and hypophosphatemic rickets

This perspective paper presents a hypothesis that links abnormalities of bone material with densitometric findings in two congenital metabolic bone disorders, osteogenesis imperfecta type I (OI) and X-linked hy weiter...

Author: Rauch F
Source: J Musculoskelet Neuronal Interact., 2006; 6(2): 142-6, PMID: 16849823
Doc-ID: 1261,
More information: Original Article

Clinical Studies

Annual change in bone mineral density in predialysis patients with chronic renal failure: significance of a decrease in serum 1,25-dihydroxy-vitamin D

Bone disease occurs in the predialysis phase of chronic renal failure (CRF). The aim of this study was to examine how a decrease in renal function affects annual bone mineral density (BMD) changes in predialysi weiter...

Author: Obatake N, Ishimura E, Tsuchida T, Hirowatari K, Naka H, Imanishi Y, Miki T, Inaba M, Nishizawa Y
Source: J Bone Miner Metab., 2007; 25(1): 74-9, PMID: 17187197
Doc-ID: 1262,

Clinical Studies

Calcium supplementation and weight bearing physical activity--do they have a combined effect on the bone density of pre-pubertal children

The adaptation of bone to exercise has been shown to be modified by dietary calcium intake. The aim of this randomised controlled trial was to investigate whether there was a differential response to calcium su weiter...

Author: Ward KA, Roberts SA, Adams JE, Lanham-New S, Mughal MZ
Source: Bone., 2007; 41(4): 496-504, PMID: 17870038
Doc-ID: 1263,

Clinical Studies

Impaired geometric properties of tibia in older women with hip fracture history

SUMMARY: This study evaluated side-to-side differences in tibial mineral mass and geometry in women with previous hip fracture sustained on average 3.5 years earlier. Both tibial mineral mass and geometry were weiter...

Author: Mikkola T, Sipilä S, Portegijs E, Kallinen M, Alén M, Kiviranta I, Pekkonen M, Heinonen A
Source: Osteoporos Int., 2007; 18(8): 1083-90, PMID: 17323107
Doc-ID: 1264,

Clinical Studies

Musculoskeletal abnormalities of the tibia in juvenile rheumatoid arthritis

OBJECTIVE: To characterize local bone geometry, density, and strength, using peripheral quantitative computed tomography (pQCT), compared with general bone characteristics as measured using dual x-ray absorptio weiter...

Author: Felin EM, Prahalad S, Askew EW, Moyer-Mileur LJ
Source: Arthritis Rheum., 2007; 56(3): 984-94, PMID: 17328076
Doc-ID: 1265,

Clinical Studies

Analyzing cortical bone cross-sectional geometry by peripheral QCT: comparison with bone histomorphometry

A distinct advantage of peripheral quantitative computed tomography (pQCT) is its ability to assess bone strength by measuring cross-sectional geometry and density of cortical bone. For accurate determination o weiter...

Author: Kontulainen S, Liu D, Manske S, Jamieson M, Sievänen H, McKay H
Source: J Clin Densitom., 2007; 10(1): 86-92, PMID: 17289530
Doc-ID: 1266,

Clinical Studies

Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study

SUMMARY: We studied the relations between bone geometry and density and the mechanical properties of human cadaveric tibiae. Bone geometry, assessed by MRI and pQCT, and bone density, assessed by DXA, were sign weiter...

Author: Liu D, Manske SL, Kontulainen SA, Tang C, Guy P, Oxland TR, McKay HA
Source: Osteoporos Int., 2007; 18(7): 991-7, PMID: 17268944
Doc-ID: 1267,

Clinical Studies

Volumetric bone density and geometry assessed by peripheral quantitative computed tomography in uremic patients on maintenance hemodialysis

The aim of this study was to establish, by means of peripheral quantitative computed tomography (pQCT) at the distal radius, the existence of cortical and/or trabecular osteopenia, and to assess the integrity o weiter...

Author: Russo CR, Taccetti G, Caneva P, Mannarino A, Maranghi P, Ricca M
Source: Osteoporos Int., 1998; 8(5): 443-8, PMID: 9850352
Doc-ID: 1268,

Clinical Studies

Can bisphosphonate treatment be stopped in a growing child with skeletal fragility

SUMMARY: Cyclical pamidronate therapy in a 2-year-old child with skeletal fragility resulted in remodelling of vertebral fractures and improvement in bone mineral density (BMD) at distal radial and spinal sites weiter...

Author: Ward KA, Adams JE, Freemont TJ, Mughal MZ
Source: Osteoporos Int., 2007; 18(8): 1137-40, PMID: 17279467
Doc-ID: 1269,

Clinical Studies

Hand dominance and bone response after a distal radial fracture: a peripheral QCT study

There are no reports on bone geometry or volumetric bone density adaptations in those who have sustained a distal radial fracture. We used peripheral quantitative computed tomography (pQCT) and dual-energy X-ra weiter...

Author: Ashe MC, Khan KM, Davis JC, Guy P, McKay HA
Source: J Clin Densitom., 2007; 10(1): 93-101, PMID: 17289531
Doc-ID: 1270,

Clinical Studies

Chocolate consumption and bone density in older women

BACKGROUND: Nutrition is important for the development and maintenance of bone structure and for the prevention of osteoporosis and fracture. The relation of chocolate intake with bone has yet to be investigate weiter...

Author: Hodgson JM, Devine A, Burke V, Dick IM, Prince RL
Source: Am J Clin Nutr., 2008; 87(1): 175-80, PMID: 18175753
Doc-ID: 1271,

Clinical Studies

Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration

OBJECTIVE: To determine the interrelations between degenerative changes in articular cartilage and underlying trabecular bone during development of osteoarthritis and to test the ability of quantitative magneti weiter...

Author: Lammentausta E, Kiviranta P, Töyräs J, Hyttinen MM, Kiviranta I, Nieminen MT, Jurvelin JS
Source: Osteoarthritis Cartilage., 2007; 15(10): 1149-57, PMID: 17502160
Doc-ID: 1272,

Clinical Studies

A structural approach to the assessment of fracture risk in children and adolescents with chronic kidney disease

Children with chronic kidney disease (CKD) have multiple risk factors for impaired accretion of trabecular and cortical bone. CKD during childhood poses an immediate fracture risk and compromises adult bone mas weiter...

Author: Leonard MB
Source: Pediatr Nephrol., 2007; 22(11): 1815-24, PMID: 17622566
Doc-ID: 1273,

Clinical Studies

Association between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD study

In this large population-based study in young men, we show that the COMT val158met polymorphism modulates the association between physical activity, aBMD (DXA), and trabecular vBMD (pQCT). INTRODUCTION: Peak BM weiter...

Author: Lorentzon M, Eriksson AL, Nilsson S, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2007; 22(8): 1165-72, PMID: 17451372
Doc-ID: 1274,

Clinical Studies

Similar effects of long-term exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestational-age (SGA) children

BACKGROUND AND AIMS: Treatment with GH in short children has focused on height development. Little is known about the concomitant changes in muscle mass, bone structure and bone strength. METHODS: Muscle area a weiter...

Author: Schweizer R, Martin DD, Haase M, Roth J, Trebar B, Binder G, Schwarze CP, Ranke MB
Source: Bone., 2007; 41(5): 875-81, PMID: 17826368
Doc-ID: 1276,

Clinical Studies

Quantifying leisure physical activity and its relation to bone density and strength

PURPOSE: Compare three published methods of quantifying physical activity (total activity, peak strain, and bone-loading exposure (BLE) scores) and identify their associations with areal bone mineral density (a weiter...

Author: Shedd KM, Hanson KB, Alekel DL, Schiferl DJ, Hanson LN, Van Loan MD
Source: Med Sci Sports Exerc., 2007; 39(12): 2189-98, PMID: 18046190
Doc-ID: 1277,

Clinical Studies

Age-related decline in trabecular and cortical density: a 5-year peripheral quantitative computed tomography follow-up study of pre- and postmenopausal women

This 5-year prospective study assessed changes in trabecular and cortical volumetric bone density at the non-weight-bearing radius and weight-bearing tibia among clinically healthy pre- and postmenopausal women weiter...

Author: Uusi-Rasi K, Sievänen H, Pasanen M, Kannus P
Source: Calcif Tissue Int., 2007; 81(4): 249-53, PMID: 17768589
Doc-ID: 1278,

Clinical Studies

Evaluation of cortical bone by peripheral quantitative computed tomography in renal transplant recipients

BACKGROUND: The absolute risk of fractures in renal transplant patients is 3 times that of matched controls. Most of the symptomatic fractures are peripheral, suggesting a greater compromise of cortical bone. P weiter...

Author: Negri AL, Lombas C, Cuevas C, Schiavelli R, Bogado CE, Zanchetta JR
Source: Transplant Proc., 2005; 37(2): 1020-2, PMID: 15848610
Doc-ID: 1204,

Clinical Studies

Loading modalities and bone structures at nonweight-bearing upper extremity and weight-bearing lower extremity: a pQCT study of adult female athletes

This cross-sectional study of adult female athletes assessed whether the apparent loading-related differences in bone structure are primarily associated with the loading type or the muscle performance-related j weiter...

Author: Nikander R, Sievänen H, Uusi-Rasi K, Heinonen A, Kannus P
Source: Bone., 2006; 39(4): 886-94, PMID: 16731064
Doc-ID: 1205,
More information: Original Article

Clinical Studies

Bone geometric response to chronic disuse following stroke: a pQCT study

OBJECTIVES: The objectives of this study were to 1) assess volumetric bone geometry and density at the distal radius of individuals with chronic stroke and 2) assess whether bone strength is associated with mea weiter...

Author: Ashe MC, Fehling P, Eng JJ, Khan KM, McKay HA
Source: J Musculoskelet Neuronal Interact., 2006; 6(3): 226-33, PMID: 17142942
Doc-ID: 1206,
More information: Original Article

Clinical Studies

Bone adaptation to altered loading after spinal cord injury: a study of bone and muscle strength

Bone loss from the paralysed limbs after spinal cord injury (SCI) is well documented. Under physiological conditions, bones are adapted to forces which mainly emerge from muscle pull. After spinal cord injury ( weiter...

Author: Rittweger J, Gerrits K, Altenburg T, Reeves N, Maganaris CN, de Haan A
Source: J Musculoskelet Neuronal Interact., 2006; 6(3): 269-76, PMID: 17142949
Doc-ID: 1207,
More information: Original Article

Clinical Studies

Effects of joint unloading and reloading on human cartilage morphology and function, muscle cross-sectional areas, and bone density - a quantitative case report

Recent studies have shown that thinning of human cartilage occurs with unloading, but no data are available on the effect of remobilization (after immobilization) on knee joint cartilage status in humans. We ex weiter...

Author: Hudelmaier M, Glaser C, Hausschild A, Burgkart R, Eckstein F
Source: J Musculoskelet Neuronal Interact., 2006; 6(3): 284-90, PMID: 17142951
Doc-ID: 1208,
More information: Original Article

Clinical Studies

Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus

OBJECTIVE: To determine whether bone characteristics in adolescents with type 1 diabetes mellitus (DM) are influenced by blood glucose regulation and disease duration. The subjects were adolescents with type 1 weiter...

Author: Heap J, Murray MA, Miller SC, Jalili T, Moyer-Mileur LJ
Source: J Pediatr., 2004; 144(1): 56-62, PMID: 14722519
Doc-ID: 1209,

Clinical Studies

Bone loss from the human distal tibia epiphysis during 24 days of unilateral lower limb suspension

Bone loss during immobilization is well documented. Currently, the only means of studying this in human beings is bed rest, which is resource intensive and inconvenient for the subjects. Unilateral lower limb s weiter...

Author: Rittweger J, Winwood K, Seynnes O, de Boer M, Wilks D, Lea R, Rennie M, Narici M
Source: J Physiol., 2006; 577(Pt 1): 331-7, PMID: 17023509
Doc-ID: 1210,

Clinical Studies

High bone mineral density in pycnodysostotic patients with a novel mutation in the propeptide of cathepsin K

INTRODUCTION: Pycnodysostosis is typically associated with short stature, multiple fractures without adequate trauma and high bone density on x-ray. The increased bone density is due to a genetic defect of cath weiter...

Author: Schilling AF, Mülhausen C, Lehmann W, Santer R, Schinke T, Rueger JM, Amling M
Source: Osteoporos Int., 2007; 18(5): 659-69, PMID: 17206399
Doc-ID: 1211,

Clinical Studies

Smoking is associated with lower bone mineral density and reduced cortical thickness in young men

CONTEXT: Smoking has previously been associated with reduced areal bone mineral density (aBMD) in elderly subjects, but the association remains controversial in adolescents. OBJECTIVE: The aim of this study was weiter...

Author: Lorentzon M, Mellström D, Haug E, Ohlsson C
Source: J Clin Endocrinol Metab., 2007; 92(2): 497-503, PMID: 17077132
Doc-ID: 1212,

Clinical Studies

Influence of birth weight and early diet on peripheral bone in premenopausal Cambridge women: a pQCT study

Epidemiological studies have shown relationships of adult bone mineral status with birth weight and diet in early life. Most of these studies used DXA to measure bone mineral content. Peripheral quantitative co weiter...

Author: Laskey MA, de Bono S, Smith EC, Prentice A
Source: J Musculoskelet Neuronal Interact., 2007; 7(1): 83, PMID: 17396013
Doc-ID: 1215,
More information: Original Article

Clinical Studies

Influence of birth weight on peripheral bone in young Gambian adults: a pQCT study

Birth weight has been shown to predict adult skeletal size and bone mineral content independently of postnatal factors. However, it is not known whether birth weight and current weight influence adult cortical weiter...

Author: de Bono S, Laskey MA, Ceesay M, Mendy M, Prentice A
Source: J Musculoskelet Neuronal Interact., 2007; 7(1): 82, PMID: 17396012
Doc-ID: 1216,
More information: Original Article

Clinical Studies

Bone loss and mechanical properties of tibia in spinal cord injured men

AIM: The effects of Spinal Cord Injury (SCI) on bone in paralyzed areas are well documented but there are few data for the importance of the level of injury in the decrease of mechanical strength in paralyzed l weiter...

Author: Dionyssiotis Y, Trovas G, Galanos A, Raptou P, Papaioannou N, Papagelopoulos P, Petropoulou K, Lyritis GP
Source: J Musculoskelet Neuronal Interact., 2007; 7(1): 62-8, PMID: 17396008
Doc-ID: 1217,
More information: Original Article

Clinical Studies

Muskel und Knochen - eine funktionelle Einheit

Einleitung: Im sich entwickelnden Organismus von Kindern und Jugendlichen steht die Kraft und die Masse der Muskulatur in biologischer Beziehung zur Geometrie und Masse des Skeletts. Methoden: Vor dem Hintergr weiter...

Author: E Schönau, O Fricke
Source: Dtsch Ärztebl 103: (2006) A3414 - 3418, 2006; 103: 3414-3418
Doc-ID: 1218,

Clinical Studies

Determinants of bone mass and bone size in a large cohort of physically active young adult men

The determinants of bone mineral density (BMD) at multiple sites were examined in a fit college population. Subjects were 755 males (mean age = 18.7 years) entering the United States Military Academy. A questio weiter...

Author: Ruffing JA, Cosman F, Zion M, Tendy S, Garrett P, Lindsay R, Nieves JW
Source: Nutr Metab (Lond)., 2006; 3: 14, PMID: 16480509
Doc-ID: 1219,
More information: Original Article

Clinical Studies

Detrimental effect of oral contraceptives on parameters of bone mass and geometry in a cohort of 248 young women

The aim of this cross-sectional analysis was to examine the skeletal effects of low-dose monophasic oral contraceptive (OC) use in a cohort of 248 young Caucasian women aged 18-24 years. Areal bone mineral dens weiter...

Author: Hartard M, Kleinmond C, Wiseman M, Weissenbacher ER, Felsenberg D, Erben RG
Source: Bone., 2007; 40(2): 444-50, PMID: 16965947
Doc-ID: 1220,

Clinical Studies

Vitamin D status and bone mass in UK South Asian women

INTRODUCTION: Low vitamin D status is prevalent among South Asians living in the UK. The relationship, however, between serum 25-hydroxyvitamin D level (25OHD), serum parathyroid level (PTH) and bone mass in th weiter...

Author: Roy DK, Berry JL, Pye SR, Adams JE, Swarbrick CM, King Y, Silman AJ, O"Neill TW
Source: Bone., 2007; 40(1): 200-4, PMID: 16950669
Doc-ID: 1221,

Clinical Studies

Effects of genes, sex, age, and activity on BMC, bone size, and areal and volumetric BMD

Quantitative genetic analyses of bone data for 710 inter-related individuals 8-85 yr of age found high heritability estimates for BMC, bone area, and areal and volumetric BMD that varied across bone sites. Acti weiter...

Author: Havill LM, Mahaney MC, L Binkley T, Specker BL
Source: J Bone Miner Res., 2007; 22(5): 737-46, PMID: 17444815
Doc-ID: 1222,

Clinical Studies

Volumetric bone mineral density and bone size in sleep-deprived individuals

INTRODUCTION: Chronic sleep deprivation, which is associated with several age-related pathologies and altered endocrine function, may adversely affect bone. Our a priori hypothesis was that bone mineral density weiter...

Author: Specker BL, Binkley T, Vukovich M, Beare T
Source: Osteoporos Int., 2007; 18(1): 93-9, PMID: 16909195
Doc-ID: 1223,

Clinical Studies

Skeletal effects of long-term estrogen and testosterone replacement treatment in a man with congenital aromatase deficiency: evidences of a priming effect of estrogen for sex steroids action on bone

The relative contribution of each sex steroid (i.e. estrogen and androgen) on bone in men and the relationships among sex steroids and changes in BMD and bone strength are still unknown. A defective BMD of bone weiter...

Author: Rochira V, Zirilli L, Madeo B, Aranda C, Caffagni G, Fabre B, Montangero VE, Roldan EJ, Maffei L, Carani C
Source: Bone., 2007; 40(6): 1662-8, PMID: 17400043
Doc-ID: 1224,

Clinical Studies

Evaluation of cortical bone by peripheral quantitative computed tomography in continuous ambulatory peritoneal dialysis patients

Several studies have suggested an increased prevalence of osteopenia in dialysis. Peripheral quantitative computed tomography (pQCT) is a new technique that allows the noninvasive evaluation of trabecular and c weiter...

Author: Negri AL, Barone R, Lombas C, Bogado CE, Zanchetta JR
Source: Hemodial Int., 2006; 10(4): 351-5, PMID: 17014510
Doc-ID: 1225,

Clinical Studies

Bone density comparison of selected carpal and tarsal bones: validation for their use in compression fracture fixation studies of scaphoid screws

INTRODUCTION: To determine if trabecular, total and cortical bone densities of the capitate, navicular, cuboid, and first cuneiform were equivalent to those of the scaphoid, such that these bones could be used weiter...

Author: Brutus JP, Rajkumar JS, Rust E, Harley BJ, Palmer AK, Werner FW
Source: Chir Main., 2006; 25(2): 77-80, PMID: 16841768
Doc-ID: 1226,

Clinical Studies

Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study

BACKGROUND: Frailty is a common condition in elders and identifies a state of vulnerability for adverse health outcomes. OBJECTIVE: Our objective was to provide a biological face validity to the well-establishe weiter...

Author: Cesari M, Leeuwenburgh C, Lauretani F, Onder G, Bandinelli S, Maraldi C, Guralnik JM, Pahor M, Ferrucci L
Source: Am J Clin Nutr., 2006; 83(5): 1142-8, PMID: 16685058
Doc-ID: 1227,

Clinical Studies

High and low density in the same bone: a study on children and adolescents with mild osteogenesis imperfecta

Children and adolescents with osteogenesis imperfecta (OI) generally have low bone mineral density (BMD) at the lumbar spine and hip. However, the effects of the disease on diaphyseal bone have not been well ch weiter...

Author: Rauch F, Land C, Cornibert S, Schoenau E, Glorieux FH
Source: Bone., 2005; 37(5): 634-41, PMID: 16112635
Doc-ID: 1228,

Clinical Studies

Bone density measurements in pediatric patients with renal osteodystrophy

Peripheral quantitative computed tomography (pQCT) can selectively measure the densities of cortical and trabecular bone, but there is limited information about its use in patients with renal osteodystrophy. Th weiter...

Author: Lima EM, Goodman WG, Kuizon BD, Gales B, Emerick A, Goldin J, Salusky IB
Source: Pediatr Nephrol., 2003; 18(6): 554-9, PMID: 12712376
Doc-ID: 1229,

Clinical Studies

Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group

To determine whether magnetic resonance (MR)-derived measures of trabecular bone architecture in the distal radius are predictive for prevalent hip fractures, 20 subjects with hip fractures and 19 age-matched p weiter...

Author: Majumdar S, Link TM, Augat P, Lin JC, Newitt D, Lane NE, Genant HK
Source: Osteoporos Int., 1999; 10(3): 231-9, PMID: 10525716
Doc-ID: 1230,

Clinical Studies

Oral glucocorticoid-induced fall in cortical bone volume and density in postmenopausal asthmatic patients

Despite a deepening understanding of the influence of glucocorticoids (GC) on trabecular bone, little is known about GC-induced cortical bone loss. To elucidate the mechanism of GC-induced loss of cortical bone weiter...

Author: Tsugeno H, Goto B, Fujita T, Okamoto M, Mifune T, Mitsunobu F, Ashida K, Hosaki Y, Tsuji T, Tanizaki Y
Source: Osteoporos Int., 2001; 12(4): 266-70, PMID: 11420775
Doc-ID: 1231,

Clinical Studies

Assessment of the tibia using ultrasonic guided waves in pubertal girls

The purpose of this study was to compare low frequency ultrasonic guided wave measurements with established ultrasound and bone density measurements in terms of their ability to characterize the tibia in pubert weiter...

Author: Moilanen P, Nicholson PH, Kärkkäinen T, Wang Q, Timonen J, Cheng S
Source: Osteoporos Int., 2003; 14(12): 1020-7, PMID: 14564455
Doc-ID: 1232,

Clinical Studies

Lasofoxifene (CP-336,156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats

The purpose of this study was to evaluate if long-term (6 months) treatment with lasofoxifene (LAS), a new selective estrogen receptor modulator (SERM), can protect against age-related changes in bone mass and weiter...

Author: Ke HZ, Qi H, Chidsey-Frink KL, Crawford DT, Thompson DD
Source: J Bone Miner Res., 2001; 16(4): 765-73, PMID: 11316005
Doc-ID: 1233,

Clinical Studies

Bone loss in patients with untreated chronic obstructive pulmonary disease is mediated by an increase in bone resorption associated with hypercapnia

This study sought to determine whether the bone loss in untreated chronic obstructive pulmonary disease (COPD) is associated with hypercapnia and/or respiratory acidosis. Bone mineral density (BMD) measured at weiter...

Author: Dimai HP, Domej W, Leb G, Lau KH
Source: J Bone Miner Res., 2001; 16(11): 2132-41, PMID: 11697811
Doc-ID: 1234,

Clinical Studies

Assessment of anthropometric, systemic, and lifestyle factors influencing bone status in the legs of spinal cord injured individuals

The aim of the present study was to assess the influence of muscle spasms, systemic or lifestyle factors on bone mass and geometry of the femur and the tibia in people with long-standing spinal cord injury (SCI weiter...

Author: Eser P, Frotzler A, Zehnder Y, Schiessl H, Denoth J
Source: Osteoporos Int., 2005; 16(1): 26-34, PMID: 15138665
Doc-ID: 1235,

Clinical Studies

Bone density and hemoglobin levels in older persons: results from the InCHIANTI study

Hypoxemia has been recognized as a risk factor for bone loss. The aim of the present study is to investigate the relationship of bone mass and density measures with anemia and hemoglobin levels in a large sampl weiter...

Author: Cesari M, Pahor M, Lauretani F, Penninx BW, Bartali B, Russo R, Cherubini A, Woodman R, Bandinelli S, Guralnik JM, Ferrucci L
Source: Osteoporos Int., 2005; 16(6): 691-9, PMID: 15455197
Doc-ID: 1236,

Clinical Studies

Musculoskeletal and functional muscle-bone analysis in children with rheumatic disease using peripheral quantitative computed tomography

Bone demineralization is a severe complication of juvenile idiopathic arthritis (JIA) and other rheumatic diseases. To identify patients, who are at risk of bone disease, musculoskeletal analysis is performed. weiter...

Author: Bechtold S, Ripperger P, Dalla Pozza R, Schmidt H, Häfner R, Schwarz HP
Source: Osteoporos Int., 2005; 16(7): 757-63, PMID: 15490121
Doc-ID: 1239,

Clinical Studies

The discriminative ability of peripheral and axial bone measurements to identify proximal femoral, vertebral, distal forearm and proximal humeral fractures: a case control study

Previous studies evaluating peripheral bone measurement devices have often used discontinued technologies, compared single devices, only evaluated a single fracture syndrome or failed to make a comparison with weiter...

Author: Clowes JA, Eastell R, Peel NF
Source: Osteoporos Int., 2005; 16(12): 1794-802, PMID: 15947861
Doc-ID: 1240,

Clinical Studies

High parity is associated with increased bone size and strength

Some, but not all, studies report an association between decreased hip fracture risk and high parity despite similar bone mineral density (BMD). Our hypothesis was that bone size, a major determinant of bone st weiter...

Author: Specker B, Binkley T
Source: Osteoporos Int., 2005; 16(12): 1969-74, PMID: 16091837
Doc-ID: 1241,

Clinical Studies

Long-term recreational gymnastics provides a clear benefit in age-related functional decline and bone loss. A prospective 6-year study

INTRODUCTION: Bone fragility and decreased functional performance are risk factors for osteoporotic fractures. The influence of long-term recreational gymnastics on the maintenance of bone rigidity and physical weiter...

Author: Uusi-Rasi K, Sievänen H, Heinonen A, Vuori I, Beck TJ, Kannus P
Source: Osteoporos Int., 2006; 17(8): 1154-64, PMID: 16758134
Doc-ID: 1242,

Clinical Studies

Device-specific thresholds to diagnose osteoporosis at the proximal femur: an approach to interpreting peripheral bone measurements in clinical practice

INTRODUCTION: A single T score criterion cannot be universally applied to different peripheral bone measurement devices, since measurements in an identical population result in a tenfold difference in the preva weiter...

Author: Clowes JA, Peel NF, Eastell R
Source: Osteoporos Int., 2006; 17(9): 1293-302, PMID: 16810454
Doc-ID: 1243,

Clinical Studies

A 19-week exercise program for people with chronic stroke enhances bone geometry at the tibia: a peripheral quantitative computed tomography study

BACKGROUND: We assessed the impact of a 19-week exercise program on bone health in chronic stroke. RESULTS: Those who underwent the program reported significantly more gain in tibial trabecular bone content weiter...

Author: Pang MY, Ashe MC, Eng JJ, McKay HA, Dawson AS
Source: Osteoporos Int., 2006; 17(11): 1615-25, PMID: 16896509
Doc-ID: 1244,

Clinical Studies

A multi-component exercise regimen to prevent functional decline and bone fragility in home-dwelling elderly women: randomized, controlled trial

Summary: This study showed that combination of strength, balance, agility and jumping training prevented functional decline and bone fragility in home-dwelling elderly women. The finding supports the idea that weiter...

Author: Karinkanta S, Heinonen A, Sievänen H, Uusi-Rasi K, Pasanen M, Ojala K, Fogelholm M, Kannus P
Source: Osteoporos Int., 2007; 18(4): 453-62, PMID: 17103296
Doc-ID: 1245,

Clinical Studies

Effect of primary hyperparathyroidism on volumetric bone mineral density and bone geometry assessed by peripheral quantitative computed tomography in postmenopausal women

CONTEXT: Primary hyperparathyroidism (PH) is characterized by inappropriate PTH elevation with or without hypercalcemia. Bone disease involves catabolic action at cortical sites, whereas cancellous sites and ge weiter...

Author: Charopoulos I, Tournis S, Trovas G, Raptou P, Kaldrymides P, Skarandavos G, Katsalira K, Lyritis GP
Source: J Clin Endocrinol Metab., 2006; 91(5): 1748-53, PMID: 16492695
Doc-ID: 1184,

Clinical Studies

Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial

BACKGROUND: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. OBJECTI weiter...

Author: Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F
Source: Am J Clin Nutr., 2005; 82(5): 1115-26; quiz 1147-8, PMID: 16280447
Doc-ID: 1185,

Clinical Studies

Reduced bone mineral density in adults treated with high-dose corticosteroids for childhood nephrotic syndrome

BACKGROUND: Children with minimal change nephrotic syndrome (MCNS) receive repeated courses of high dose oral prednisolone. No previous study has investigated the impact of this on final bone mineral density (B weiter...

Author: Hegarty J, Mughal MZ, Adams J, Webb NJ
Source: Kidney Int., 2005; 68(5): 2304-9, PMID: 16221233
Doc-ID: 1186,

Clinical Studies

Structural adaptations to bone loss in aging men and women

INTRODUCTION: Bone apposition on the subperiosteal surface and bone loss from the endocortical surface during aging establish the external diameter, total cross-sectional area (tCSA), cortical thickness (Ct.Th) weiter...

Author: Russo CR, Lauretani F, Seeman E, Bartali B, Bandinelli S, Di Iorio A, Guralnik J, Ferrucci L
Source: Bone., 2006; 38(1): 112-8, PMID: 16242391
Doc-ID: 1187,

Clinical Studies

Accuracy of pQCT for evaluating the aged human radius: an ashing, histomorphometry and failure load investigation

INTRODUCTION: Quantifying the determinants of bone strength is essential to understanding if or how the structure will fail under load. Determining failure requires knowledge of material and geometric propertie weiter...

Author: Ashe MC, Khan KM, Kontulainen SA, Guy P, Liu D, Beck TJ, McKay HA
Source: Osteoporos Int., 2006; 17(8): 1241-51, PMID: 16683179
Doc-ID: 1188,

Clinical Studies

Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study

The importance of pubertal timing for adult BMD in males was studied through association of pubertal timing with young adult bone phenotype. Pubertal timing was found to predict both cortical and trabecular vol weiter...

Author: Kindblom JM, Lorentzon M, Norjavaara E, Hellqvist A, Nilsson S, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2006; 21(5): 790-5, PMID: 16734395
Doc-ID: 1189,

Clinical Studies

Intravenous bisphosphonate therapy increases radial width in adults with osteogenesis imperfecta

Neridronate therapy in adult patients with OI significantly increases the cross-sectional area of the proximal radius. This observation may provide an additional explanation for the antifracture efficacy of bis weiter...

Author: Gatti D, Viapiana O, Lippolis I, Braga V, Prizzi R, Rossini M, Adami S
Source: J Bone Miner Res., 2005; 20(8): 1323-6, PMID: 16007328
Doc-ID: 1190,

Clinical Studies

Cortical pQCT measures are associated with fractures in dialysis patients

To determine if pQCT could identify HD patients with fractures, we conducted a cross-sectional study in 52 men and women on HD. We found that cortical, but not trabecular, pQCT measures were associated with fra weiter...

Author: Jamal SA, Gilbert J, Gordon C, Bauer DC
Source: J Bone Miner Res., 2006; 21(4): 543-8, PMID: 16598374
Doc-ID: 1191,

Clinical Studies

Change in cortical bone density and its distribution differs between boys and girls during puberty

CONCEPT: Postmenarchal girls and premenopausal women have 3-4% higher cortical bone density (CoD, milligrams per cubic centimeter), compared with postpubertal boys and men, respectively. Females" denser cortica weiter...

Author: Kontulainen SA, Macdonald HM, McKay HA
Source: J Clin Endocrinol Metab., 2006; 91(7): 2555-61, PMID: 16636118
Doc-ID: 1192,

Clinical Studies

Association of amount of physical activity with cortical bone size and trabecular volumetric BMD in young adult men: the GOOD study

In this population-based study, amount of PA was associated with cortical bone size (increased thickness and periosteal circumference) and trabecular vBMD, but not with cortical vBMD or length of the long bones weiter...

Author: Lorentzon M, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2005; 20(11): 1936-43, PMID: 16234966
Doc-ID: 1193,

Clinical Studies

Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD study

In this study, we evaluated the predictive roles of sex steroids for skeletal parameters in young men (n = 1068) at the age of peak bone mass. Serum free estradiol was a negative predictor, whereas free testost weiter...

Author: Lorentzon M, Swanson C, Andersson N, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2005; 20(8): 1334-41, PMID: 16007330
Doc-ID: 1194,

Clinical Studies

The state of pediatric bone: summary of the ASBMR pediatric bone initiative

Author: Klein GL, Fitzpatrick LA, Langman CB, Beck TJ, Carpenter TO, Gilsanz V, Holm IA, Leonard MB, Specker BL, ASBMR Group
Source: J Bone Miner Res., 2005; 20(12): 2075-81, PMID: 16294260
Doc-ID: 1195,

Clinical Studies

Magnesium and muscle performance in older persons: the InCHIANTI study

BACKGROUND: The role of magnesium in maintaining muscle integrity and function in older adults is largely unknown. OBJECTIVE: We aimed to investigate the relation between serum magnesium concentrations and musc weiter...

Author: Dominguez LJ, Barbagallo M, Lauretani F, Bandinelli S, Bos A, Corsi AM, Simonsick EM, Ferrucci L
Source: Am J Clin Nutr., 2006; 84(2): 419-26, PMID: 16895893
Doc-ID: 1196,

Clinical Studies

A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency

CONTEXT: Low bone mass is a characteristic feature of the adult GH deficiency (GHD) syndrome, but recent dual-energy x-ray absorptiometry (DXA) studies in patients with GH-receptor and GHRH-receptor gene mutati weiter...

Author: Murray RD, Adams JE, Shalet SM
Source: J Clin Endocrinol Metab., 2006; 91(2): 432-8, PMID: 16278268
Doc-ID: 1197,

Clinical Studies

Effect of protein supplementation during a 6-month strength and conditioning program on areal and volumetric bone parameters

BACKGROUND: Skeletal loading and proper nutrition are necessary for optimal bone health. The appropriate amount of dietary protein to maximize skeletal health, however, is under constant debate. OBJECTIVE: To d weiter...

Author: Ballard TL, Specker BL, Binkley TL, Vukovich MD
Source: Bone., 2006; 38(6): 898-904, PMID: 16364710
Doc-ID: 1198,

Clinical Studies

Changes in bone mass and bone turnover following tibial shaft fracture

INTRODUCTION: Bone loss occurs in the regional bone following tibial shaft fracture. An earlier cross-sectional study showed that measurements made at the metaphyseal region of the tibia using peripheral quanti weiter...

Author: Veitch SW, Findlay SC, Hamer AJ, Blumsohn A, Eastell R, Ingle BM
Source: Osteoporos Int., 2006; 17(3): 364-72, PMID: 16362144
Doc-ID: 1199,

Clinical Studies

COL1A1 Sp1 polymorphism associates with bone density in early puberty

Optimal acquisition of bone mass in puberty is a key determinant of the lifetime risk of osteoporosis and has a strong genetic basis. We investigated the relationship between the COL1A1 Sp1 polymorphism and BMD weiter...

Author: Suuriniemi M, Kovanen V, Mahonen A, Alén M, Wang Q, Lyytikäinen A, Cheng S
Source: Bone., 2006; 39(3): 591-7, PMID: 16580273
Doc-ID: 1201,

Clinical Studies

Correlates of bone quality in older persons

PURPOSE OF THE STUDY: In a population-based sample of older persons, we studied the relationship between tibial bone density and geometry and factors potentially affecting osteoporosis. METHODS: Of the 1260 par weiter...

Author: Lauretani F, Bandinelli S, Russo CR, Maggio M, Di Iorio A, Cherubini A, Maggio D, Ceda GP, Valenti G, Guralnik JM, Ferrucci L
Source: Bone., 2006; 39(4): 915-21, PMID: 16709469
Doc-ID: 1202,

Clinical Studies

Effects of age, grip strength and smoking on forearm volumetric bone mineral density and bone geometry by peripheral quantitative computed tomography: comparisons between female and male

Peripheral quantitative computed tomography (pQCT) is useful to measure volumetric bone mineral density (vBMD) distinguishing trabecular from cortical bones as well as quantity of bone geometry. In the present weiter...

Author: Kaji H, Kosaka R, Yamauchi M, Kuno K, Chihara K, Sugimoto T
Source: Endocr J., 2005; 52(6): 659-66, PMID: 16410656
Doc-ID: 1203,

Clinical Studies

Case-control study of the muscular compartments and osseous strength in neurofibromatosis type 1 using peripheral quantitative computed tomography

Skeletal anomalies are observed in neurofibromatosis type 1 (NF1), but the pathogenesis is unknown. Given that muscle mass is important in the development of the strength of bone, peripheral quantitative comput weiter...

Author: Stevenson DA, Moyer-Mileur LJ, Carey JC, Quick JL, Hoff CJ, Viskochil DH
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 145-9, PMID: 15951630
Doc-ID: 1163,
More information: Original Article

Clinical Studies

Co-existence of X-linked hypophosphatemic rickets (XLH) and primary hyperparathyroidism: case report and review of the literature

X-linked hypophosphatemic rickets (XLH) is a dominant disorder characterized by hypophosphatemia due to impaired renal tubular reabsorption of inorganic phosphate. Cardinal manifestations include defective calc weiter...

Author: Tournis ST, Giannikou PV, Paspati IN, Katsalira EA, Voskaki IC, Lyritis GP
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 150-4, PMID: 15951631
Doc-ID: 1164,
More information: Original Article

Clinical Studies

A cybernetic approach to osteoporosis in anorexia nervosa

A group of 25 female individuals, who had been admitted to the University Hospital with the diagnosis of anorexia nervosa (AN) 3 to 10 years before, was seen for a follow-up visit in the hospital. These women g weiter...

Author: Fricke O, Tutlewski B, Stabrey A, Lehmkuhl G, Schöenau E
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 155-61, PMID: 15951632
Doc-ID: 1165,
More information: Original Article

Clinical Studies

Quantitative bone analysis in children: current methods and recommendations

Over the past decade there have been an increasing number of published manuscripts dealing with pediatric bone mineral density (BMD). The reason for this interest is 2-fold. First, there is a belief that bone g weiter...

Author: Specker BL, Schoenau E
Source: J Pediatr., 2005; 146(6): 726-31, PMID: 15973307
Doc-ID: 1166,

Clinical Studies

Speed of sound: relation to geometric characteristics of bone in children, adolescents, and adults

OBJECTIVES: To investigate the relation between volumetric bone mineral density (vBMD) and speed of sound (SOS). STUDY DESIGN: Total and trabecular vBMD were measured by peripheral quantitative computed tomogra weiter...

Author: Fricke O, Tutlewski B, Schwahn B, Schoenau E
Source: J Pediatr., 2005; 146(6): 764-8, PMID: 15973315
Doc-ID: 1167,

Clinical Studies

L-arginine, the natural precursor of NO, is not effective for preventing bone loss in postmenopausal women

NO is an important regulator of bone turnover. L-Arginine, the natural precursor of NO, can enhance NO production. However, no effect of L-arginine hydrochloride supplementation was found on bone metabolism or weiter...

Author: Baecker N, Boese A, Schoenau E, Gerzer R, Heer M
Source: J Bone Miner Res., 2005; 20(3): 471-9, PMID: 15746992
Doc-ID: 1168,

Clinical Studies

Fracture threshold in the femur and tibia of people with spinal cord injury as determined by peripheral quantitative computed tomography

OBJECTIVE: To determine bone traits of the femur and tibia with peripheral quantitative computed tomography (pQCT) that best distinguish between spinal cord injury (SCI) subjects with and without fractures. DES weiter...

Author: Eser P, Frotzler A, Zehnder Y, Denoth J
Source: Arch Phys Med Rehabil., 2005; 86(3): 498-504, PMID: 15759235
Doc-ID: 1169,

Clinical Studies

Bone geometry and density in the skeleton of pre-pubertal gymnasts and school children

We have studied the differences between the peripheral and axial skeleton of pre-pubertal gymnasts and controls. We hypothesised that compared to controls, gymnasts would have larger and stronger radius and tib weiter...

Author: Ward KA, Roberts SA, Adams JE, Mughal MZ
Source: Bone., 2005; 36(6): 1012-8, PMID: 15876561
Doc-ID: 1173,

Clinical Studies

Bone structure and volumetric density in young adults born prematurely: a peripheral quantitative computed tomography study

Prematurity is known to be associated with reduced bone mineral density (BMD) in childhood, but whether this condition has long-term detrimental consequences on adult bone structure is not known. In this study, weiter...

Author: Backström MC, Kuusela AL, Koivisto AM, Sievänen H
Source: Bone., 2005; 36(4): 688-93, PMID: 15780965
Doc-ID: 1174,

Clinical Studies

Maturity- and sex-related changes in tibial bone geometry, strength and bone-muscle strength indices during growth: a 20-month pQCT study

During growth, bone strength is conferred through subtle adaptations in bone mass and geometry in response to muscle forces. Few studies have examined the changes in bone geometry, strength and the bone-muscle weiter...

Author: Macdonald HM, Kontulainen SA, Mackelvie-O"Brien KJ, Petit MA, Janssen P, Khan KM, McKay HA
Source: Bone., 2005; 36(6): 1003-11, PMID: 15823517
Doc-ID: 1175,

Clinical Studies

Muscle atrophy and bone loss after 90 days" bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study

Muscle atrophy and bone loss pose substantial problems for long-term space flight and in clinical immobilization. We therefore tested the efficacy of flywheel resistive exercise and pamidronate to counteract su weiter...

Author: Rittweger J, Frost HM, Schiessl H, Ohshima H, Alkner B, Tesch P, Felsenberg D
Source: Bone., 2005; 36(6): 1019-29, PMID: 15811637
Keywords: Flywheel BedRest
Doc-ID: 1176,

Clinical Studies

Neurofibromin and its inactivation of Ras are prerequisites for osteoblast functioning

Skeletal problems and osteoporosis occur in up to 50% affected neurofibromatosis type 1 (NF1) humans. Inactivation of neurofibromin results in deregulation of Ras signal transduction. Little is known of bone bi weiter...

Author: Yu X, Chen S, Potter OL, Murthy SM, Li J, Pulcini JM, Ohashi N, Winata T, Everett ET, Ingram D, Clapp WD, Hock JM
Source: Bone., 2005; 36(5): 793-802, PMID: 15804420
Doc-ID: 1177,

Clinical Studies

Bone loss is detected more frequently in patients with ankylosing spondylitis with syndesmophytes

OBJECTIVE: To define the relationship between bone growth (syndesmophytes) and bone loss (osteoporosis) in ankylosing spondylitis (AS). METHODS: Bone mineral density (BMD) at the spine, hip, and radius was meas weiter...

Author: Karberg K, Zochling J, Sieper J, Felsenberg D, Braun J
Source: J Rheumatol., 2005; 32(7): 1290-8, PMID: 15996067
Doc-ID: 1178,

Clinical Studies

Differences in peak bone mass in women of European and South Asian origin can be explained by differences in body size

There are few data concerning the occurrence of peak bone mass in women of South Asian origin. The aim of this study was to determine the level of peak bone mass in South Asian women in the UK and to determine weiter...

Author: Roy D, Swarbrick C, King Y, Pye S, Adams J, Berry J, Silman A, O"Neill T
Source: Osteoporos Int., 2005; 16(10): 1254-62, PMID: 15702264
Doc-ID: 1179,

Clinical Studies

Digital radiogrammetry as a new diagnostic tool for estimation of disease-related osteoporosis in rheumatoid arthritis compared with pQCT

OBJECTIVES: To investigate the potential of a new osteogeometric technology based on digital X-ray radiogrammetry (DXR) as a diagnostic tool for quantification of severity-dependent osteoporosis, and to disting weiter...

Author: Böttcher J, Pfeil A, Heinrich B, Lehmann G, Petrovitch A, Hansch A, Heyne JP, Mentzel HJ, Malich A, Hein G, Kaiser WA
Source: Rheumatol Int., 2005; 25(6): 457-64, PMID: 15761729
Doc-ID: 1180,

Clinical Studies

Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children

BACKGROUND: Protein and alkalizing minerals are increasingly described as playing a major role in influencing bone status, not only in the elderly but also in children and adolescents. OBJECTIVE: We examined wh weiter...

Author: Alexy U, Remer T, Manz F, Neu CM, Schoenau E
Source: Am J Clin Nutr., 2005; 82(5): 1107-14, PMID: 16280446
Doc-ID: 1181,

Clinical Studies

Bone measurements by peripheral quantitative computed tomography (pQCT) in children with cerebral palsy

OBJECTIVE: To use peripheral quantitative computed tomography (pQCT) to determine bone measurements in patients with cerebral palsy (CP) age 3 to 20 years and compare them with control subjects. STUDY DESIGN: A weiter...

Author: Binkley T, Johnson J, Vogel L, Kecskemethy H, Henderson R, Specker B
Source: J Pediatr., 2005; 147(6): 791-6, PMID: 16356433
Doc-ID: 1182,

Clinical Studies

Rural versus nonrural differences in BMC, volumetric BMD, and bone size: a population-based cross-sectional study

Despite reports of lower fracture risk among rural versus urban populations, few studies have investigated rural versus urban differences in bone mineral content (BMC) and bone mineral density (BMD). Population weiter...

Author: Specker B, Binkley T, Fahrenwald N
Source: Bone., 2004; 35(6): 1389-98, PMID: 15589221
Doc-ID: 1153,

Clinical Studies

Increased periosteal circumference remains present 12 months after an exercise intervention in preschool children

We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine weiter...

Author: Specker B, Binkley T, Fahrenwald N
Source: Bone., 2004; 35(6): 1383-8, PMID: 15589220
Doc-ID: 1154,

Clinical Studies

Mechanical strength of the proximal femur as predicted from geometric and densitometric bone properties at the lower limb versus the distal radius

This experimental study compares geometric and densitometric properties of cortical and trabecular bone at the lower limb and the distal radius with those at the femoral neck, and evaluates their ability to pre weiter...

Author: Lochmüller EM, Groll O, Kuhn V, Eckstein F
Source: Bone., 2002; 30(1): 207-16, PMID: 11792587
Doc-ID: 1156,

Clinical Studies

Growth hormone changes bone geometry and body composition in patients with juvenile idiopathic arthritis requiring glucocorticoid treatment: a controlled study using peripheral quantitative computed tomography

Osteopenia and growth retardation have been described in children with chronic arthritis. GH has an impact on both. In the present controlled study, we used peripheral quantitative computed tomography to evalua weiter...

Author: Bechtold S, Ripperger P, Bonfig W, Pozza RD, Haefner R, Schwarz HP
Source: J Clin Endocrinol Metab., 2005; 90(6): 3168-73, PMID: 15769991
Doc-ID: 1158,

Clinical Studies

Association of an aromatase TTTA repeat polymorphism with circulating estrogen, bone structure, and biochemistry in older women

Osteoporosis is a disease that is strongly genetically determined. Aromatase converts androgens to estradiol in postmenopausal women, therefore polymorphisms of the gene for this enzyme may be associated with b weiter...

Author: Dick IM, Devine A, Prince RL
Source: Am J Physiol Endocrinol Metab., 2005; 288(5): E989-95, PMID: 15613678
Doc-ID: 1159,

Clinical Studies

Three children with lower limb fractures and a mineralization defect: a novel bone fragility disorder

In this report, we describe three unrelated children with an apparently novel bone fragility disorder that is associated with an idiopathic mineralization defect. Recurrent lower limb fractures started with wei weiter...

Author: Munns CF, Rauch F, Travers R, Glorieux FH
Source: Bone., 2004; 35(5): 1023-8, PMID: 15542026
Doc-ID: 1161,

Clinical Studies

Peripheral quantitative computed tomography of the distal radius in young subjects - new reference data and interpretation of results

Application of bone densitometry to clinical use requires the availability of accessible reference data and is helped by an interpretative framework that is based on bone physiology. The aim of this contributio weiter...

Author: Rauch F, Schöenau E
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 119-26, PMID: 15951627
Doc-ID: 1162,
More information: Original Article

Clinical Studies

Total, trabecular, and cortical bone mineral density in different regions of the glenoid

The purpose of this study was to analyze total, trabecular, and cortical bone mineral density (BMD) of different regions of the glenoid. Soft tissue was dissected from 20 cadaveric shoulders, and the glenoids w weiter...

Author: Lehtinen JT, Tingart MJ, Apreleva M, Warner JJ
Source: J Shoulder Elbow Surg., 2004; 13(3): 344-8, PMID: 15111907
Doc-ID: 1143,

Clinical Studies

Estimation of bone mineral density and architectural parameters of the distal radius in hemodialysis patients using peripheral quantitative computed tomography

We analyzed bone changes in a series of hemodialysis patients followed up for a maximum of 299 months by assessing bone mineral density (BMD) and architectural parameters of the distal radius using peripheral q weiter...

Author: Hasegawa K, Hasegawa Y, Nagano A
Source: J Biomech., 2004; 37(5): 751-6, PMID: 15047004
Doc-ID: 1144,

Clinical Studies

Bone mineral density in children with primary hyperoxaluria type I

BACKGROUND: In primary hyperoxaluria type I (PH 1), hepatic overproduction of oxalate leads to its deposition in various organ systems including bone (oxalosis). To evaluate skeletal status non-invasively in PH weiter...

Author: Behnke B, Kemper MJ, Kruse HP, Müller-Wiefel DE
Source: Nephrol Dial Transplant., 2001; 16(11): 2236-9, PMID: 11682674
Doc-ID: 1145,

Clinical Studies

Lower estimates of net endogenous non-carbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women

BACKGROUND: The link between acid-base homeostasis and skeletal integrity has gained increasing prominence in the literature. Estimation of the net rate of endogenous non-carbonic acid production (NEAP) from di weiter...

Author: New SA, MacDonald HM, Campbell MK, Martin JC, Garton MJ, Robins SP, Reid DM
Source: Am J Clin Nutr., 2004; 79(1): 131-8, PMID: 14684409
Doc-ID: 1146,

Clinical Studies

Estrogens are essential for male pubertal periosteal bone expansion

The skeletal response to estrogen therapy was studied in a 17-yr-old boy with congenital aromatase deficiency. As expected, estrogen therapy (1 mg estradiol valeriate/d from age 17 until 20 yr) normalized total weiter...

Author: Bouillon R, Bex M, Vanderschueren D, Boonen S
Source: J Clin Endocrinol Metab., 2004; 89(12): 6025-9, PMID: 15579754
Doc-ID: 1147,

Clinical Studies

Is muscle power output a key factor in the age-related decline in physical performance? A comparison of muscle cross section, chair-rising test and jumping power

Ageing compromises locomotor capacity and is associated with an increased risk of falls. Several lines of evidence indicate that both changes in muscle mass and performance are causative. Most studies, however, weiter...

Author: Runge M, Rittweger J, Russo CR, Schiessl H, Felsenberg D
Source: Clin Physiol Funct Imaging., 2004; 24(6): 335-40, PMID: 15522042
Doc-ID: 1148,
More information: Original Article

Clinical Studies

The clinical significance of serum osteocalcin and N-terminal propeptide of type I collagen in predialysis patients with chronic renal failure

Several new serum markers for bone metabolism have recently become available and are being applied to clinical practice. Their clinical usefulness in predialysis patients with chronic renal failure (CRF), howev weiter...

Author: Tsuchida T, Ishimura E, Miki T, Matsumoto N, Naka H, Jono S, Inaba M, Nishizawa Y
Source: Osteoporos Int., 2005; 16(2): 172-9, PMID: 15164161
Doc-ID: 1149,

Clinical Studies

Bone loss and steady state after spinal cord injury: a cross-sectional study using pQCT

Author: Eser P, Schiessl H, Willnecker J
Source: J Musculoskelet Neuronal Interact., 2004; 4(2): 197-8, PMID: 15615125
Doc-ID: 1152,
More information: Original Article

Clinical Studies

Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites

This study comprehensively analyzes the ability of site-specific and nonsite-specific clinical densitometric techniques for predicting mechanical strength of the distal radius in different loading configuration weiter...

Author: Lochmüller EM, Lill CA, Kuhn V, Schneider E, Eckstein F
Source: J Bone Miner Res., 2002; 17(9): 1629-38, PMID: 12211433
Doc-ID: 1133,

Clinical Studies

Interpretation of whole body dual energy X-ray absorptiometry measures in children: comparison with peripheral quantitative computed tomography

The assessment of bone health in children requires strategies to minimize the confounding effects of bone size on dual energy X-ray absorptiometry (DXA) areal bone mineral density (BMD) results. Cortical bone c weiter...

Author: Leonard MB, Shults J, Elliott DM, Stallings VA, Zemel BS
Source: Bone., 2004; 34(6): 1044-52, PMID: 15193552
Doc-ID: 1134,

Clinical Studies

Androgens and bone

Loss of estrogens or androgens increases the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal imbalance between resorption and format weiter...

Author: Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C
Source: Endocr Rev., 2004; 25(3): 389-425, PMID: 15180950
Doc-ID: 1135,

Clinical Studies

The bone mass concept: problems in short stature

Bone densitometry is currently one of the mainstays in the evaluation of systemic bone diseases in adults and is also increasingly used to assess primary or secondary bone disorders in children and adolescents. weiter...

Author: Schoenau E, Land C, Stabrey A, Remer T, Kroke A
Source: Eur J Endocrinol., 2004; 151 Suppl 1: S87-91, PMID: 15339251
Doc-ID: 1137,

Clinical Studies

Accuracy and precision of peripheral quantitative computed tomography measurements at the tibial metaphysis

The ability of 29 peripheral quantitative computed tomography (pQCT) software analysis modes at defining cortical from trabecular bone at three tibial metaphyseal regions was evaluated using five cadaveric tibi weiter...

Author: Veitch SW, Findlay SC, Ingle BM, Ibbotson CJ, Barrington A, Hamer AJ, Eastell R
Source: J Clin Densitom., 2004; 7(2): 209-17, PMID: 15181265
Doc-ID: 1139,

Clinical Studies

Analysis of the functional muscle-bone unit of the forearm in pediatric renal transplant recipients

BACKGROUND: Renal transplantation in children and adolescents is associated with various skeletal complications. The incidence of spontaneous fractures appears to be increased, but the reasons for this are not weiter...

Author: Rüth EM, Weber LT, Schoenau E, Wunsch R, Seibel MJ, Feneberg R, Mehls O, Tönshoff B
Source: Kidney Int., 2004; 66(4): 1694-706, PMID: 15458468
Doc-ID: 1140,

Clinical Studies

Hemoglobin levels and skeletal muscle: results from the InCHIANTI study

BACKGROUND: Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative a weiter...

Author: Cesari M, Penninx BW, Lauretani F, Russo CR, Carter C, Bandinelli S, Atkinson H, Onder G, Pahor M, Ferrucci L
Source: J Gerontol A Biol Sci Med Sci., 2004; 59(3): 249-54, PMID: 15031309
Doc-ID: 1141,

Clinical Studies

Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)

The diagnosis of osteoporosis is generally based on the assessment of bone mineral content with dual X-ray absorptiometry (DXA) but does not account for the spatial distribution and inherent material properties weiter...

Author: Hudelmaier M, Kuhn V, Lochmüller EM, Well H, Priemel M, Link TM, Eckstein F
Source: Osteoporos Int., 2004; 15(5): 375-81, PMID: 14740151
Doc-ID: 1142,

Clinical Studies

Volumetric and projective bone mineral density

Projectional bone mineral density measurement so far used extensively in radiogrammetry and single and dual source absorptiometry is confronted with a serious limitation for the accurate evaluation of true dens weiter...

Author: Fujita T
Source: J Musculoskelet Neuronal Interact., 2002; 2(4): 302-5, PMID: 15758420
Doc-ID: 1115,
More information: Original Article

Clinical Studies

Aging bone in men and women: beyond changes in bone mineral density

Using peripheral quantitative computed tomography (pQCT) we assessed trabecular and cortical bone density, mass and geometric distribution at the tibia level in 512 men and 693 women, age range 20-102 years, ra weiter...

Author: Russo CR, Lauretani F, Bandinelli S, Bartali B, Di Iorio A, Volpato S, Guralnik JM, Harris T, Ferrucci L
Source: Osteoporos Int., 2003; 14(7): 531-8, PMID: 12827220
Doc-ID: 1116,

Clinical Studies

Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodeling

Dual energy x-ray absorptiometry (DEXA) has revealed that GH- deficient adults gain in bone mineral density during GH therapy. Measurements of volumetric bone density (grams per cubic centimeter vs. grams per s weiter...

Author: Schweizer R, Martin DD, Schwarze CP, Binder G, Georgiadou A, Ihle J, Ranke MB
Source: J Clin Endocrinol Metab., 2003; 88(11): 5266-72, PMID: 14602760
Doc-ID: 1117,

Clinical Studies

The volumetric bone density and cortical thickness in adult patients affected by osteogenesis imperfecta

In patients with osteogenesis imperfecta (OI), a disease characterized by abnormal bone fragility, bone mineral density (BMD) was found to be relatively preserved. Quantitative computed tomography (QCT) is the weiter...

Author: Gatti D, Colapietro F, Fracassi E, Sartori E, Antoniazzi F, Braga V, Rossini M, Adami S
Source: J Clin Densitom., 2003; 6(2): 173-7, PMID: 12794240
Doc-ID: 1118,

Clinical Studies

Predicting the failure load of the distal radius

The distal radius is an important site for the early detection of patients at risk for fracture. Since measuring bone strength in vivo is not possible, we evaluated which bone assessment method of the forearm w weiter...

Author: Muller ME, Webber CE, Bouxsein ML
Source: Osteoporos Int., 2003; 14(4): 345-52, PMID: 12730737
Doc-ID: 1119,

Clinical Studies

Hormone replacement therapy improves distal radius bone structure by endocortical mineral deposition

Hormone replacement therapy (HRT) produces a small increase in bone mineral density (BMD) when measured by dual energy X-ray absorptiometry (DXA). The corresponding decrease in fracture risk is more impressive, weiter...

Author: Muller ME, Webber CE, Adachi JD
Source: Can J Physiol Pharmacol., 2003; 81(10): 952-8, PMID: 14608412
Doc-ID: 1121,

Clinical Studies

Effects of an excess and a deficiency of endogenous parathyroid hormone on volumetric bone mineral density and bone geometry determined by peripheral quantitative computed tomography in female subjects

Peripheral quantitative computed tomography (pQCT) is useful for evaluating volumetric bone mineral density (vBMD) as well as bone mineral density (BMD) of cortical and trabecular bones separately. Although PTH weiter...

Author: Chen Q, Kaji H, Iu MF, Nomura R, Sowa H, Yamauchi M, Tsukamoto T, Sugimoto T, Chihara K
Source: J Clin Endocrinol Metab., 2003; 88(10): 4655-8, PMID: 14557436
Doc-ID: 1122,

Clinical Studies

Age- and gender-related differences in vertebral bone mass, density, and strength

This study was designed to evaluate age- and gender-related differences in vertebral bone mass, density, and strength by dual-energy X-ray absorptiometry (DXA), quantitative computed tomography (QCT), periphera weiter...

Author: Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde L
Source: J Bone Miner Res., 1999; 14(8): 1394-403, PMID: 10457272
Doc-ID: 1124,

Clinical Studies

Predicting human vertebral bone strength by vertebral static histomorphometry

The study investigates the relationship between static histomorphometry and bone strength of human lumbar vertebral bone. The ability of vertebral histomorphometry to predict vertebral bone strength was compare weiter...

Author: Thomsen JS, Ebbesen EN, Mosekilde L
Source: Bone., 2002; 30(3): 502-8, PMID: 11882465
Doc-ID: 1125,

Clinical Studies

Relationship between the duration of paralysis and bone structure: a pQCT study of spinal cord injured individuals

The aim of the present study was to describe bone loss of the separate compartments of trabecular and cortical bone, as well as changes in bone geometry of a large number of spinal cord injured (SCI) individual weiter...

Author: Eser P, Frotzler A, Zehnder Y, Wick L, Knecht H, Denoth J, Schiessl H
Source: Bone., 2004; 34(5): 869-80, PMID: 15121019
Doc-ID: 1126,

Clinical Studies

Augmentation experimentale de la resistance du radius distal osteoporotique par un ciment phosphocalcique

Le diagnostic et le traitement de l’ostéoporose sont focalisés sur la lutte contre la déminéralisation. Or, la densité minérale de l’os n’est pas directement corrélée à la résistance mécanique weiter...

Author: P Liverneaux
Source: Chirurgie de la main, 2004; 23: 37-44
Doc-ID: 1128,

Clinical Studies

Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometry

OBJECTIVE: Alterations of the skeletal system, including reduced bone mineral density, increased frequency of fractures, and changes in markers of bone metabolism, have been described in juvenile idiopathic art weiter...

Author: Roth J, Palm C, Scheunemann I, Ranke MB, Schweizer R, Dannecker GE
Source: Arthritis Rheum., 2004; 50(4): 1277-85, PMID: 15077312
Doc-ID: 1131,
More information: Original Article

Clinical Studies

Skeletal adaptations in hemiplegic patients

Author: Runge M, Rehfeld G, Schiessl H
Source: J Musculoskelet Neuronal Interact., 2004; 4(2): 191-6, PMID: 15615124
Doc-ID: 1132,
More information: Original Article

Clinical Studies

Peripheral Quantitative Computed Tomography of the Tibia: Pediatric Reference Values

Peripheral quantitative computed tomography (pQCT) has been used in a number of pediatric studies. Reference data for children are primarily limited to the radius. The purpose of this study was to establish nor weiter...

Author: Moyer-Mileur LJ, Quick JL, Murray MA
Source: J Clin Densitom., 2008; PMID: 18164637
Keywords: pädiatrie
Doc-ID: 1114,

Clinical Studies

Neuromuscular adaptations during long-term bed rest

Author: Mulder ER
Source: Dissertation, 2007;
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 1111,
Download:

Clinical Studies

Effects of Whole-Body Vibration Exercise on Lower-Extremity Muscle Strength and Power in an Older Population: A Randomized Clinical Trial

BACKGROUND AND PURPOSE:/b> Vibration training is a relatively new exercise intervention. This study investigated the effects of vibration exercise on strength (force-producing capacity) and power in older adult weiter...

Author: Rees SS, Murphy AJ, Watsford ML
Source: Phys Ther., 2008; PMID: 18218826
Doc-ID: 1098,

Clinical Studies

Differential effects of whole body vibration durations on knee extensor strength

The effectiveness and optimality of whole body vibration (WBV) duration on muscular strength is yet to be determined. Hence the aim of this study was to investigate the effects of three different durations of c weiter...

Author: Stewart JA, Cochrane DJ, Morton RH
Source: J Sci Med Sport., 2009; PMID: 18078783
Doc-ID: 1106,
More information: Original Article

Clinical Studies

Whole Body Vibration and Dynamic Restraint

The purpose of this study was to identify changes due to whole body vibration in peroneus longus (PL) activation following ankle inversion perturbation. Participants were 22 (age 22.1 +/- 1.8 yrs, ht 168.8 +/- weiter...

Author: Hopkins T, Pak JO, Robertshaw AE, Feland JB, Hunter I, Gage M
Source: Int J Sports Med., 2007; PMID: 17879889
Doc-ID: 1107,

Clinical Studies

Alter-und geschlechtsabhängige Knochenmineraldichteverteilung und mechanische Eigenschaften des proximalen Humerus

Author: H Lill, P Hepp, W Gowin, JW Oestmann, J Korner, NP Haas, C Josten, GN Duda
Source: Fortschr. Röntgenstr., 2002; 174: 1544-1550
Doc-ID: 1078,

Clinical Studies

Analysis of the structure and strength of bones in celiac disease patients

OBJECTIVE: The aim of this study was to gain insight into the pathogenesis of bone mass loss and weakening affecting patients with celiac disease, according to the new concepts of bone structure/strength and mu weiter...

Author: Ferretti J, Mazure R, Tanoue P, Marino A, Cointry G, Vazquez H, Niveloni S, Pedreira S, Mauriño E, Zanchetta J, Bai JC
Source: Am J Gastroenterol., 2003; 98(2): 382-90, PMID: 12591059
Doc-ID: 1079,

Clinical Studies

Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis

Treatment with teriparatide (rDNA origin) injection [teriparatide, recombinant human parathyroid hormone (1-34) [rhPTH(1-34)]] reduces the risk of vertebral and nonvertebral fragility fractures and increases ca weiter...

Author: Zanchetta JR, Bogado CE, Ferretti JL, Wang O, Wilson MG, Sato M, Gaich GA, Dalsky GP, Myers SL
Source: J Bone Miner Res., 2003; 18(3): 539-43, PMID: 12619939
Doc-ID: 1080,

Clinical Studies

Mandible and maxilla bone mineral density and threshold analysis studies by pQCT in two edentulous women receiving pamidronate

The mandible and maxilla of two edentulous women, treated during 25 weeks with oral pamidronate, were monitored by peripheral quantitative tomography (pQCT). Whole bone volumetric mineral density failed to show weiter...

Author: Montangero VE, Capiglioni R, Roldán EJ
Source: Cranio., 2003; 21(2): 110-5, PMID: 12723856
Doc-ID: 1084,

Clinical Studies

The value of peripheral quantitative computed tomography (pQCT) in the diagnosis of osteoporosis

AIM: To evaluate the accuracy of distal radial pQCT in discriminating between osteoporotic fracture and non fracture cases and its efficiency to predict fractures. METHODS: Densitometric data determined with an weiter...

Author: Niedhart C, Braun K, Graf Stenbock-Fermor N, Bours F, Schneider P, Zilkens KW, Niethard FU
Source: Z Orthop Ihre Grenzgeb., 2003; 141(2): 135-42, PMID: 12695948
Doc-ID: 1085,

Clinical Studies

Bone mass and density response to a 12-month trial of calcium and vitamin D supplement in preadolescent girls

BACKGROUND: Maximal bone acquisition in adolescent girls through dietary and lifestyle practices is advocated to prevent or minimize the development of osteoporosis and its associated complications in later lif weiter...

Author: Moyer-Mileur LJ, Xie B, Ball SD, Pratt T
Source: J Musculoskelet Neuronal Interact., 2003; 3(1): 63-70, PMID: 15758367
Doc-ID: 1086,
More information: Original Article

Clinical Studies

Die Muskel-Knochen-Einheit im Kindes- und Jugendalter. Konsequenzen für Prävention und Klassifikation der Osteoporose

Author: E Schönau
Source: Extracta Orthopaedica, 2002; 11: 20-25
Doc-ID: 1087,

Clinical Studies

Bone quality parameters of the distal radius as assessed by pQCT in normal and fractured women

The aim of this study was to test the ability of some indicators of different aspects of bone quality (assessed by peripheral quantitative computed tomography in the distal radius) to discriminate between fract weiter...

Author: Schneider P, Reiners C, Cointry GR, Capozza RF, Ferretti JL
Source: Osteoporos Int., 2001; 12(8): 639-46, PMID: 11580077
Doc-ID: 1089,

Clinical Studies

Age, sex, and grip strength determine architectural bone parameters assessed by peripheral quantitative computed tomography (pQCT) at the human radius

The purpose of this study was to estimate the relation of some noninvasively derived mechanical characteristics of radial bone including architectural parameters for bone strength to grip strength and muscle cr weiter...

Author: Hasegawa Y, Schneider P, Reiners C
Source: J Biomech., 2001; 34(4): 497-503, PMID: 11266673
Doc-ID: 1090,

Clinical Studies

Measurement of bone adjacent to tibial shaft fracture

Delayed union and non-union are common complications after fracture of the tibial shaft. Response of the surrounding bone as a fracture heals could be monitored using techniques currently used in the study of o weiter...

Author: Findlay SC, Eastell R, Ingle BM
Source: Osteoporos Int., 2002; 13(12): 980-9, PMID: 12459941
Doc-ID: 1094,

Clinical Studies

Peripheral quantitative Computed Tomography (PQCT) in the evaluation of bone geometry, biomechanics and mineral density in postmenopausal women

AIM: Non-invasive assessment of bone geometry, biomechanics, and mineral content in postmenopausal women by peripheral quantitative Computed Tomography (pQCT). MATERIAL AND METHODS: Total, trabecular and cortic weiter...

Author: Di Leo C, Tarolo GL, Bagni B, Bestetti A, Tagliabue L, Pietrogrande L, Pepe L
Source: Radiol Med (Torino)., 2002; 103(3): 233-41, PMID: 11976620
Doc-ID: 1095,

Clinical Studies

Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis

Despite an intriguing understanding of trabecular bone dynamics, little is known about corticosteroid-induced cortical bone loss and fractures. Recently, we verified a steroid-induced decrease in cortical bone weiter...

Author: Tsugeno H, Tsugeno H, Fujita T, Goto B, Sugishita T, Hosaki Y, Ashida K, Mitsunobu F, Tanizaki Y, Shiratori Y
Source: Osteoporos Int., 2002; 13(8): 650-6, PMID: 12181624
Doc-ID: 1096,

Clinical Studies

Effect of alendronate and exercise on bone and physical performance of postmenopausal women: a randomized controlled trial

In this randomized, double-blind, placebo-controlled 12-month trial we evaluated effects of weight- bearing jumping exercise and oral alendronate, alone or in combination, on the mass and structure of bone, ris weiter...

Author: Uusi-Rasi K, Kannus P, Cheng S, Sievänen H, Pasanen M, Heinonen A, Nenonen A, Halleen J, Fuerst T, Genant H, Vuori I
Source: Bone., 2003; 33(1): 132-43, PMID: 12919708
Doc-ID: 1097,

Clinical Studies

Changes of trabecular bone density in elderly subjects: a 4-year prospective pQCT study

In large cohort studies changes in bone density and mass are often described statistically as mean values over a period of time1,2. This implies that bone loss occurs homogeneously in the study population over weiter...

Author: Schiessl H, Runge M, Willnecker J
Source: J Musculoskelet Neuronal Interact., 2006; 6(2): 160-1, PMID: 16849826
Doc-ID: 1070,
More information: Original Article

Clinical Studies

Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine

OBJECTIVE: To examine bone development in children and adolescents who have uncomplicated idiopathic epilepsy and had received monotherapy with carbamazepine or valproic acid for at least 1 year. METHODS: Thirt weiter...

Author: Rieger-Wettengl G, Tutlewski B, Stabrey A, Rauch F, Herkenrath P, Schauseil-Zipf U, Schoenau E
Source: Pediatrics., 2001; 108(6): E107, PMID: 11731634
Doc-ID: 1075,

Clinical Studies

Analysis of muscle strength and bone structure in children with renal disease

Bone structure and muscular strength of 30 children with renal disease were investigated by peripheral computed tomography and grip strength. Sixteen children suffered from nephrotic syndrome (NS) and had previ weiter...

Author: Tenbrock K, Kruppa S, Mokov E, Querfeld U, Michalk D, Schoenau E
Source: Pediatr Nephrol., 2000; 14(7): 669-72, PMID: 10912540
Doc-ID: 1076,

Clinical Studies

Patient-specific microarchitecture of vertebral cancellous bone: a peripheral quantitative computed tomographic and histological study

This study directly compares peripheral quantitative computed tomography (pQCT) and histology for the assessment of 11 morphological parameters. Sixty-eight cylindrical cancellous bone samples were cored from t weiter...

Author: Banse X, Devogelaer JP, Grynpas M
Source: Bone., 2002; 30(6): 829-35, PMID: 12052449
Doc-ID: 1077,

Clinical Studies

High-impact exercise and bones of growing girls: a 9-month controlled trial

The maximum amount of bone a person can obtain during the first two decades of life is an important determinant of bone mass in later life, and an increase in peak bone mass has been associated with decreased r weiter...

Author: Heinonen A, Sievänen H, Kannus P, Oja P, Pasanen M, Vuori I
Source: Osteoporos Int., 2000; 11(12): 1010-7, PMID: 11256891
Doc-ID: 1047,

Clinical Studies

Ultrasound velocity and cortical bone characteristics in vivo

Axial transmission of ultrasound along cortical bone may reflect a combination of material and structural properties of long bone cortices. The goal of this study was to determine the association of speed of so weiter...

Author: Sievänen H, Cheng S, Ollikainen S, Uusi-Rasi K
Source: Osteoporos Int., 2001; 12(5): 399-405, PMID: 11444089
Doc-ID: 1048,

Clinical Studies

Postmenopausal changes in the distribution of the volumetric BMD of cortical bone. A pQCT study of the human leg

Three different regions of interest (ROIs) were defined in pQCT scans (XCT-3000 machine, Stratec, Germany) taken at the tibial mid-diaphyses of 12 pre-menopausal (pre-MP) and 12 post-menopausal (post-MP) women weiter...

Author: Roldán EJ, Capiglioni R, Cointry CR, Capozza RF, Ferretti JL
Source: J Musculoskelet Neuronal Interact., 2001; 2(2): 157-62, PMID: 15758464
Doc-ID: 1049,
More information: Original Article

Clinical Studies

Peripheral quantitative computed tomography at the distal radius: cross-calibration between two scanners

Peripheral quantitative computed tomography (pQCT) is an important technique to study the interaction between the muscle and bone systems. We have recently established pQCT reference ranges for children, adoles weiter...

Author: Rauch F, Tutlewski B, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2001; 2(2): 153-5, PMID: 15758463
Doc-ID: 1050,
More information: Original Article

Clinical Studies

Predictive value of Singh index and bone mineral density measured by quantitative computed tomography in determining the local cancellous bone quality of the proximal femur

OBJECTIVE: The purpose of this study was to assess the predictive value of the Singh index as well as quantitative computed tomography for the in vitro local mechanical competence of the cancellous bone of the weiter...

Author: Wachter NJ, Augat P, Hoellen IP, Krischak GD, Sarkar MR, Mentzel M, Kinzl L, Claes L
Source: Clin Biomech (Bristol, Avon)., 2001; 16(3): 257-62, PMID: 11240062
Doc-ID: 1051,

Clinical Studies

Prediction of strength of cortical bone in vitro by microcomputed tomography

OBJECTIVE: The aim of this study was to evaluate the predictive value of bone mineral density and intracortical porosity measured by microcomputed tomography for the strength of cortical bone biopsies. DESIGN: weiter...

Author: Wachter NJ, Augat P, Krischak GD, Sarkar MR, Mentzel M, Kinzl L, Claes L
Source: Clin Biomech (Bristol, Avon)., 2001; 16(3): 252-6, PMID: 11240061
Doc-ID: 1052,

Clinical Studies

Bone mineral content per muscle cross-sectional area as an index of the functional muscle-bone unit

Bone densitometric data often are difficult to interpret in children and adolescents because of large inter- and intraindividual variations in bone size. Here, we propose a functional approach to bone densitome weiter...

Author: Schoenau E, Neu CM, Beck B, Manz F, Rauch F
Source: J Bone Miner Res., 2002; 17(6): 1095-101, PMID: 12054165
Doc-ID: 1053,

Clinical Studies

Gender-specific pubertal changes in volumetric cortical bone mineral density at the proximal radius

It is well established that puberty affects the geometry of cortical bone differently in females and males. In the present study we investigated whether there are also gender differences in the volumetric bone weiter...

Author: Schoenau E, Neu CM, Rauch F, Manz F
Source: Bone., 2002; 31(1): 110-3, PMID: 12110422
Doc-ID: 1055,

Clinical Studies

Correlation of bone mineral density with strength and microstructural parameters of cortical bone in vitro

The aim of this study was to evaluate the influence of microstructural parameters, such as porosity and osteon dimensions, on strength. Therefore, the predictive value of bone mineral density (BMD) measured by weiter...

Author: Wachter NJ, Krischak GD, Mentzel M, Sarkar MR, Ebinger T, Kinzl L, Claes L, Augat P
Source: Bone., 2002; 31(1): 90-5, PMID: 12110418
Doc-ID: 1056,

Clinical Studies

Musculoskeletal analyses of the forearm in young women with Turner syndrome: a study using peripheral quantitative computed tomography

Turner syndrome (TS) is associated with multiple skeletal abnormalities. Fracture incidence appears to be increased, but the reasons for this are not entirely clear. In the present study, we used peripheral qua weiter...

Author: Bechtold S, Rauch F, Noelle V, Donhauser S, Neu CM, Schoenau E, Schwarz HP
Source: J Clin Endocrinol Metab., 2001; 86(12): 5819-23, PMID: 11739445
Doc-ID: 1057,

Clinical Studies

Site-specific skeletal response to long-term weight training seems to be attributable to principal loading modality: a pQCT study of female weightlifters

Physical training may be able to improve bone strength through site-specific changes in the composition, size and structure of the bone without notable increases in volumetric density. To address this possibili weiter...

Author: Heinonen A, Sievänen H, Kannus P, Oja P, Vuori I
Source: Calcif Tissue Int., 2002; 70(6): 469-74, PMID: 12016461
Doc-ID: 1058,

Clinical Studies

Cut-off values determined for vertebral fracture by peripheral quantitative computed tomography in Japanese women

In spite of the benefits of bone mass measurement by dual-energy X-ray absorptiometry (DXA), the use of DXA has limitations. It is unable to assess a true bone density, and cannot discriminate between the trabe weiter...

Author: Gorai I, Nonaka K, Kishimoto H, Sakata H, Fujii Y, Fujita T
Source: Osteoporos Int., 2001; 12(9): 741-8, PMID: 11605740
Doc-ID: 1059,

Clinical Studies

Influence of puberty on muscle development at the forearm

Despite its fundamental importance for physical development, the growth of the muscle system has received relatively little consideration. In this study, we analyzed the relationship between cross-sectional are weiter...

Author: Neu CM, Rauch F, Rittweger J, Manz F, Schoenau E
Source: Am J Physiol Endocrinol Metab., 2002; 283(1): E103-7, PMID: 12067849
Doc-ID: 1060,

Clinical Studies

The bone behind a low areal bone mineral density: peripheral quantitative computed tomographic analysis in a woman with osteogenesis imperfecta

Areal bone mineral density (BMD) is the most widely used densitometric parameter. However, this approach makes it difficult to understand the structural basis of bone diseases, because a large number of bone pr weiter...

Author: Rauch F, Tutlewski B, Schönau E
Source: J Musculoskelet Neuronal Interact., 2002; 2(4): 306-8, PMID: 15758421
Doc-ID: 1061,
More information: Original Article

Clinical Studies

The muscle-bone relationship: methods and management - perspectives in glycogen storage disease

Currently bone development is commonly presented as a process leading to the "accumulation of peak bone mass". Consequently, the usual approach to a suspected bone disorder in a child is to address the question weiter...

Author: Schönau E, Schwahn B, Rauch F
Source: Eur J Pediatr., 2002; 161 Suppl 1: S50-2, PMID: 12373571
Doc-ID: 1062,

Clinical Studies

Anthropometric assessment of muscularity during growth: estimating fat-free mass with 2 skinfold-thickness measurements is superior to measuring midupper arm muscle area in healthy prepubertal children

BACKGROUND: Anthropometric measurements are widely used to determine body composition, especially in children. OBJECTIVE: Our aim was to compare 2 of the simplest anthropometry-based equations available for det weiter...

Author: Boye KR, Dimitriou T, Manz F, Schoenau E, Neu C, Wudy S, Remer T
Source: Am J Clin Nutr., 2002; 76(3): 628-32, PMID: 12198010
Doc-ID: 1063,

Clinical Studies

The developing bone: slave or master of its cells and molecules

A large number of molecular, cellular, and epidemiologic factors have been implicated in the regulation of bone development. A major unsolved problem is how to integrate these disparate findings into a concept weiter...

Author: Rauch F, Schoenau E
Source: Pediatr Res., 2001; 50(3): 309-14, PMID: 11518815
Doc-ID: 1064,

Clinical Studies

Modeling of cross-sectional bone size, mass and geometry at the proximal radius: a study of normal bone development using peripheral quantitative computed tomography

It is becoming increasingly accepted that bone size is an important determinant of bone mass. Studies on the development of bone size may therefore promote a better understanding of the basis of diseases which weiter...

Author: Neu CM, Rauch F, Manz F, Schoenau E
Source: Osteoporos Int., 2001; 12(7): 538-47, PMID: 11527050
Doc-ID: 1065,

Clinical Studies

Changes in bone density during childhood and adolescence: an approach based on bone"s biological organization

Bone densitometry has great potential to improve our understanding of bone development. However, densitometric data in children rarely are interpreted in light of the biological processes they reflect. To stren weiter...

Author: Rauch F, Schoenau E
Source: J Bone Miner Res., 2001; 16(4): 597-604, PMID: 11315987
Doc-ID: 1066,

Clinical Studies

Estrogen and bone-muscle strength and mass relationships

The largest voluntary loads on bones come from muscles. To adapt bone strength and mass to them, special strain threshold ranges determine where modeling adds and strengthens bone, and where remodeling conserve weiter...

Author: Schiessl H, Frost HM, Jee WS
Source: Bone., 1998; 22(1): 1-6, PMID: 9437507
Doc-ID: 998,

Clinical Studies

Noninvasive Assessment of Bone Architecture and Biomechanical Properties in Animals and Humans Employing pQCT Technology

Author: J L Ferretti
Source: J Jpn Soc Bone Morphom, 1997; 7: 115-125
Doc-ID: 999,

Clinical Studies

Peripheral QCT for the diagnosis of osteoporosis

Author: Ito M, Tsurusaki K, Hayashi K
Source: Osteoporos Int., 1997; 7 Suppl 3: S120-7, PMID: 9536317
Doc-ID: 1001,

Clinical Studies

Diagnostic sensitivity of peripheral quantitative computed tomography measurements at ultradistal and proximal radius in postmenopausal women

Peripheral quantitative computed tomography (pQCT) is a bone densitometry technique that is able to provide real volumetric bone density values not only of the total but also of trabecular and cortical bone sep weiter...

Author: Nijs J, Westhovens R, Joly J, Cheng XG, Borghs H, Dequeker J
Source: Bone., 1998; 22(6): 659-64, PMID: 9626405
Doc-ID: 1002,

Clinical Studies

Measurement of forearm bone in children by peripheral computed tomography

By means of peripheral computed tomography (pQCT), adult cortical bone density and volume was shown to be under a fixed rectilinear relationship regardless of age, sex, and presence or absence of osteoporosis. weiter...

Author: Fujita T, Fujii Y, Goto B
Source: Calcif Tissue Int., 1999; 64(1): 34-9, PMID: 9868281
Doc-ID: 1003,

Clinical Studies

Bone density reduction in various measurement sites in men and women with osteoporotic fractures of spine and hip: the European quantitation of osteoporosis study

We have measured bone mineral density (BMD) using dual X-ray absorptiometry (DXA) of the spine and hip, spinal quantitative computed tomography (QCTspi), and peripheral radial quantitative computed tomography ( weiter...

Author: Kröger H, Lunt M, Reeve J, Dequeker J, Adams JE, Birkenhager JC, Diaz Curiel M, Felsenberg D, Hyldstrup L, Kotzki P, Laval-Jeantet A, Lips P, Louis O, Perez Cano R, Reiners C, Ribot C, Ruegsegger P, Schneider P, Braillon P, Pearson J
Source: Calcif Tissue Int., 1999; 64(3): 191-9, PMID: 10024374
Doc-ID: 1004,

Clinical Studies

Peripheral quantitative computed tomography in human long bones: evaluation of in vitro and in vivo precision

Despite the excellent performance in clinical practice and research, the dual-energy X-ray absorptiometry is restricted by the inherent planar nature of the measurement and the inability to discriminate between weiter...

Author: Sievänen H, Koskue V, Rauhio A, Kannus P, Heinonen A, Vuori I
Source: J Bone Miner Res., 1998; 13(5): 871-82, PMID: 9610752
Doc-ID: 1005,

Clinical Studies

Clinical evaluation of a high-resolution new peripheral quantitative computerized tomography (pQCT) scanner for the bone densitometry at the lower limbs

Precision, long-term stability, linearity and accuracy of the x-ray peripheral quantitative computerized tomographic (pQCT) bone scanner XCT 3000 (Norland-Stratec Medical Sys.) were evaluated using the European weiter...

Author: Braun MJ, Meta MD, Schneider P, Reiners C
Source: Phys Med Biol., 1998; 43(8): 2279-94, PMID: 9725604
Doc-ID: 1006,

Clinical Studies

The development of the skeletal system in children and the influence of muscular strength

In a study on 14 healthy children aged from 6 to 13 years, the volumetric spongiosa bone density (SBD), cortical bone density (CBD), bone cross-sectional area (BCSA), cortical area (CA), and bone strength index weiter...

Author: Schönau E
Source: Horm Res., 1998; 49(1): 27-31, PMID: 9438782
Doc-ID: 1007,

Clinical Studies

Problems of bone analysis in childhood and adolescence

The monitoring of bone metabolism and skeletal development during childhood and adolescence is becoming increasingly important in the prevention of osteoporosis. This is especially important in patients with ch weiter...

Author: Schönau E
Source: Pediatr Nephrol., 1998; 12(5): 420-9, PMID: 9686965
Doc-ID: 1008,

Clinical Studies

Influence of muscle strength on bone strength during childhood and adolescence

In connection with the prevention of osteoporosis, paediatrics is challenged with ensuring the optimal formation of the skeletal system with maximal bone strength during childhood and youth. Biomechanical use r weiter...

Author: Schönau E, Werhahn E, Schiedermaier U, Mokow E, Schiessl H, Scheidhauer K, Michalk D
Source: Horm Res., 1996; 45 Suppl 1: 63-6, PMID: 8805035
Doc-ID: 1009,

Clinical Studies

Alendronate increases bone density and bone strength at the distal radius in postmenopausal women

In addition to the alendronate Osteoporosis Intervention Trial (FOSIT) core protocol 901-0A of 1908 enrolled patients, the use of peripheral quantitative computed tomography (pQCT) was explored for the assessme weiter...

Author: Schneider PF, Fischer M, Allolio B, Felsenberg D, Schröder U, Semler J, Ittner JR
Source: J Bone Miner Res., 1999; 14(8): 1387-93, PMID: 10457271
Doc-ID: 1010,

Clinical Studies

Long-term recreational gymnastics, estrogen use, and selected risk factors for osteoporotic fractures

The purpose of this cross-sectional study was to examine whether long-term participation in recreational gymnastics or folk dancing or estrogen replacement therapy (ERT) is associated with mechanically more com weiter...

Author: Uusi-Rasi K, Sievänen H, Vuori I, Heinonen A, Kannus P, Pasanen M, Rinne M, Oja P
Source: J Bone Miner Res., 1999; 14(7): 1231-8, PMID: 10404026
Doc-ID: 1011,

Clinical Studies

Comparison of total and regional body composition in adolescent patients with anorexia nervosa and pair-matched controls

Body composition in 31 adolescent girls suffering from anorexia nervosa (AN) was measured at the time of hospitalization in order to assess the muscle/bone relationship as a potential source of the development weiter...

Author: Schneider P, Biko J, Schlamp D, Trott GE, Badura F, Warnke A, Reiners C
Source: Eat Weight Disord., 1998; 3(4): 179-87, PMID: 10728169
Doc-ID: 1012,

Clinical Studies

Age at menarche and cortical bone geometry in premenopausal women

Previous studies have suggested that the timing of puberty might have an impact on the adult skeleton. What composite of bone structure could be affected by the timing of puberty is unknown at present. In this weiter...

Author: Rauch F, Klein K, Allolio B, Schönau E
Source: Bone., 1999; 25(1): 69-73, PMID: 10423024
Doc-ID: 1013,

Clinical Studies

Trabecular bone mineral and calculated structure of human bone specimens scanned by peripheral quantitative computed tomography: relation to biomechanical properties

The relationship of cortical bone mineral density (BMD), and geometry to bone strength has been well documented. In this study, we used peripheral quantitative computerized tomography (pQCT) to acquire trabecul weiter...

Author: Jiang Y, Zhao J, Augat P, Ouyang X, Lu Y, Majumdar S, Genant HK
Source: J Bone Miner Res., 1998; 13(11): 1783-90, PMID: 9797489
Doc-ID: 1014,

Clinical Studies

Tomographical description of tennis-loaded radius: reciprocal relation between bone size and volumetric BMD

Effects of long-term tennis loading on volumetric bone mineral density (vBMD) and geometric properties of playing-arm radius were examined. Paired forearms of 16 tennis players (10 women) and 12 healthy control weiter...

Author: Ashizawa N, Nonaka K, Michikami S, Mizuki T, Amagai H, Tokuyama K, Suzuki M
Source: J Appl Physiol., 1999; 86(4): 1347-51, PMID: 10194221
Doc-ID: 1015,

Clinical Studies

Bone metabolism and bone mineral density in childhood hypophosphatasia

Childhood hypophosphatasia (HP) is an inborn error of bone metabolism, characterized by a reduced tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Bone mineral density (BMD) in childhood HP has no weiter...

Author: Girschick HJ, Schneider P, Kruse K, Huppertz HI
Source: Bone., 1999; 25(3): 361-7, PMID: 10495141
Doc-ID: 1016,

Clinical Studies

Age-related changes in the biochemical properties of human cancellous bone collagen: relationship to bone strength

The metabolism of bone collagen has received little attention in relation to age-related loss of bone mass and strength. The aim of the present study was to analyze bone collagen content and metabolism in human weiter...

Author: Bailey AJ, Sims TJ, Ebbesen EN, Mansell JP, Thomsen JS, Mosekilde L
Source: Calcif Tissue Int., 1999; 65(3): 203-10, PMID: 10441651
Doc-ID: 1017,

Clinical Studies

Age-related changes assessed by peripheral QCT in healthy Italian women

The purpose of this study was to describe the normal cross-sectional pattern of radial bone loss associated with aging in healthy women and to generate a normative database using peripheral quantitative compute weiter...

Author: Guglielmi G, De Serio A, Fusilli S, Scillitani A, Chiodini I, Torlontano M, Cammisa M
Source: Eur Radiol., 2000; 10(4): 609-14, PMID: 10795543
Doc-ID: 1018,

Clinical Studies

Peripheral quantitative computed tomography of the femoral neck in 60 Japanese women

Peripheral quantitative computed tomography (pQCT) is able to evaluate trabecular and cortical bone separately, and to determine geometric properties from cross-sectional images for noninvasive assessments of m weiter...

Author: Horikoshi T, Endo N, Uchiyama T, Tanizawa T, Takahashi HE
Source: Calcif Tissue Int., 1999; 65(6): 447-53, PMID: 10594163
Doc-ID: 1019,

Clinical Studies

Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing

Bone densitometry with DXA (dual energy X-ray absorptiometry) and QCT (quantitative computed tomography) techniques are used for in vivo assessment of bone strength and thereby prediction of fracture risk. Howe weiter...

Author: Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde L
Source: Bone., 1999; 25(6): 713-24, PMID: 10593417
Doc-ID: 1020,

Clinical Studies

Precision and intersite correlation of bone densitometry at the radius, tibia and femur with peripheral quantitative CT

OBJECTIVE: To compare the in situ precision of peripheral quantitative CT (pQCT) at the radius, tibia and femur, and to analyze the intersite correlation, in order to determine whether measurements at the lower weiter...

Author: Groll O, Lochmüller EM, Bachmeier M, Willnecker J, Eckstein F
Source: Skeletal Radiol., 1999; 28(12): 696-702, PMID: 10653365
Doc-ID: 1021,

Clinical Studies

Perspectives on bone mechanical properties and adaptive response to mechanical challenge

The bones of the human skeleton serve a mechanical function besides providing a reservoir for calcium and hematopoietic homeostatis. When mechanically challenged, they usually respond and adapt; failure to do s weiter...

Author: Jiang Y, Zhao J, Rosen C, Geusens P, Genant HK
Source: J Clin Densitom., 1999; 2(4): 423-33, PMID: 10677796
Doc-ID: 1023,

Clinical Studies

On new opportunities for absorptiometry

Mechanical loads cause bone strains; and muscle forces, not body weight, cause the largest strains. The strains help to control the effects of bone modeling and remodeling on bone strength and "mass." When stra weiter...

Author: Ferretti JL, Schiessl H, Frost HM
Source: J Clin Densitom., 1998; 1(1): 41-53, PMID: 15304912
Doc-ID: 1024,

Clinical Studies

Ultrasonographic, axial, and peripheral measurements in female patients with benign hypermobility syndrome

Twenty-five female Caucasians, aged 19-57 years, with the hypermobility syndrome had bone density measurements using established noninvasive techniques such as dual X-ray absorptiometry (DXA), single photon abs weiter...

Author: Nijs J, Van Essche E, De Munck M, Dequeker J
Source: Calcif Tissue Int., 2000; 67(1): 37-40, PMID: 10908410
Doc-ID: 1025,

Clinical Studies

Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players

Bilateral bone characteristics of the humerus (proximal, shaft, and distal sites) and radius (shaft and distal sites) in 12 former Finnish national-level male tennis players (mean age 30 years) and their 12 age weiter...

Author: Haapasalo H, Kontulainen S, Sievänen H, Kannus P, Järvinen M, Vuori I
Source: Bone., 2000; 27(3): 351-7, PMID: 10962345
Doc-ID: 1028,

Clinical Studies

Biomechanical Examinations for Validation of the Bone Strength Strain Index SSI, Calculated by Peripheral Quantitative Computed Tomography

Author: G Wilhelm, D Felsenberg, G Bogusch, J Willnecker, J Thaten, P Gummert
Source: MusculoSkeletal Interactions, 2000; 2: 47-52
Doc-ID: 1029,

Clinical Studies

Musculoskeletal Interactions in Normal Subjects and Dialysis Patients

Author: CR Russo
Source: MusculoSkeletal Interactions, 2000; 2: 105 - 110
Doc-ID: 1030,
Download:

Clinical Studies

Densitometric and tomographic analyses of musculoskeletal interactions in humans

Previous studies with standard densitometry (DXA) have suggested that the bone mass is strongly dependent on the muscle mass in the species, following a similar relationship at any age and sex hormones or relat weiter...

Author: Ferretti JL, Capozza RF, Cointry GR, Capiglioni R, Roldan EJ, Zanchetta JR
Source: J Musculoskelet Neuronal Interact., 2000; 1(1): 31-4, PMID: 15758522
Doc-ID: 1031,
More information: Original Article

Clinical Studies

Contributions of bone density and geometry to the strength of the human second metatarsal

We investigated, at the whole bone level, the contribution of bone density and geometry to the fracture load of the second metatarsal, a bone that is prone to stress fracture. Dual-energy X-ray absorptiometry ( weiter...

Author: Muehleman C, Lidtke R, Berzins A, Becker JH, Shott S, Sumner DR
Source: Bone., 2000; 27(5): 709-14, PMID: 11062360
Doc-ID: 1032,

Clinical Studies

Predictive value of bone mineral density and morphology determined by peripheral quantitative computed tomography for cancellous bone strength of the proximal femur

Peripheral quantitative computed tomography (pQCT) is an established diagnostic method for assessment of bone mineral density in the diagnosis of osteoporosis. However, the capacity of structural parameters of weiter...

Author: Wachter NJ, Augat P, Mentzel M, Sarkar MR, Krischak GD, Kinzl L, Claes LE
Source: Bone., 2001; 28(1): 133-9, PMID: 11165955
Doc-ID: 1033,

Clinical Studies

Bone density in asthmatic children treated with inhaled corticosteroids

Volumetric trabecular bone mineral density of the lumbar spine (vTBMD) and distal radius (rTBMD) were measured in 20 prepubertal white asthmatic children treated with moderate to high doses of inhaled corticost weiter...

Author: Reilly SM, Hambleton G, Adams JE, Mughal MZ
Source: Arch Dis Child., 2001; 84(2): 183-4, PMID: 11159303
Doc-ID: 1034,

Clinical Studies

Bone-muscle strength indices for the human lower leg

This cross-sectional study is based on images from the lower leg as assessed by peripheral quantitative computer tomography (pQCT). Measurements were performed in 39 female and 38 male control subjects and 15 f weiter...

Author: Rittweger J, Beller G, Ehrig J, Jung C, Koch U, Ramolla J, Schmidt F, Newitt D, Majumdar S, Schiessl H, Felsenberg D
Source: Bone., 2000; 27(2): 319-26, PMID: 10913929
Doc-ID: 1035,

Clinical Studies

The development of bone strength at the proximal radius during childhood and adolescence

Current investigations of bone development mostly focus on bone mass, but bone strength may be functionally more important than mass. Therefore, we compared the developmental changes in cortical bone mass (BMCc weiter...

Author: Schoenau E, Neu CM, Rauch F, Manz F
Source: J Clin Endocrinol Metab., 2001; 86(2): 613-8, PMID: 11158018
Doc-ID: 1036,

Clinical Studies

Bone densities and bone size at the distal radius in healthy children and adolescents: a study using peripheral quantitative computed tomography

Peripheral quantitative computed tomography (pQCT) has the ability to improve the diagnostic utility of densitometry in children and adolescents, because bone size and volumetric bone mineral density (vBMD) can weiter...

Author: Neu CM, Manz F, Rauch F, Merkel A, Schoenau E
Source: Bone., 2001; 28(2): 227-32, PMID: 11182383
Doc-ID: 1037,

Clinical Studies

Association of the vitamin D receptor genotype BB with low bone density in hyperthyroidism

Bone mineral density (BMD) is modulated by genetic and environmental factors or certain diseases. In several conditions such as low calcium intake, an influence of vitamin D receptor (VDR) polymorphisms on BMD weiter...

Author: Obermayer-Pietsch BM, Frühauf GE, Chararas K, Mikhail-Reinisch S, Renner W, Berghold A, Kenner L, Lackner C
Source: J Bone Miner Res., 2000; 15(10): 1950-5, PMID: 11028447
Doc-ID: 1039,

Clinical Studies

Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health

BACKGROUND: The role of nutritional influences on bone health remains largely undefined because most studies have focused attention on calcium intake. OBJECTIVE: We reported previously that intakes of nutrients weiter...

Author: New SA, Robins SP, Campbell MK, Martin JC, Garton MJ, Bolton-Smith C, Grubb DA, Lee SJ, Reid DM
Source: Am J Clin Nutr., 2000; 71(1): 142-51, PMID: 10617959
Doc-ID: 1040,

Clinical Studies

Peripheral computed tomography (pQCT) detected short-term effect of AAACa (heated oyster shell with heated algal ingredient HAI): a double-blind comparison with CaCO3 and placebo

Trabecular bone density at the distal radius and cortical bone density at the midradius were measured in four randomized groups of women before and after 4 months administration of AAACa, oyster shell heated un weiter...

Author: Fujita T, Fujii Y, Goto B, Miyauchi A, Takagi Y
Source: J Bone Miner Metab., 2000; 18(4): 212-5, PMID: 10874600
Doc-ID: 1041,

Clinical Studies

pQCT measurement of bone parameters in young children: validation of technique

Dual-energy X-ray absorptiometry (DXA) measures areal bone mineral density (BMD) and is affected by bone size. Peripheral quantitative computed tomography (pQCT) measures volumetric density and should not be af weiter...

Author: Binkley TL, Specker BL
Source: J Clin Densitom., 2000; 3(1): 9-14, PMID: 10745298
Doc-ID: 1042,

Clinical Studies

Inhomogeneity of human vertebral cancellous bone: systematic density and structure patterns inside the vertebral body

In the spine, cancellous bone quality is usually assessed for the whole vertebral body in a transverse central slice. Correct identification and assessment of the weakest parts of the cancellous bone may lead t weiter...

Author: Banse X, Devogelaer JP, Munting E, Delloye C, Cornu O, Grynpas M
Source: Bone., 2001; 28(5): 563-71, PMID: 11344057
Doc-ID: 1043,

Clinical Studies

The development of metaphyseal cortex--implications for distal radius fractures during growth

Fractures of the distal radial metaphysis are very common in otherwise healthy children. The reasons for this high fracture incidence are not entirely clear. To address this problem, we undertook a detailed ana weiter...

Author: Rauch F, Neu C, Manz F, Schoenau E
Source: J Bone Miner Res., 2001; 16(8): 1547-55, PMID: 11499878
Doc-ID: 1044,

Clinical Studies

Estimation of the architectural properties of cortical bone using peripheral quantitative computed tomography

We assessed the volumetric bone mineral density (vBMD) and cross-sectional architecture of cortical bone at the distal radius by peripheral quantitative computed tomography (pQCT). The volumetric bone mineral d weiter...

Author: Hasegawa Y, Schneider P, Reiners C, Kushida K, Yamazaki K, Hasegawa K, Nagano A
Source: Osteoporos Int., 2000; 11(1): 36-42, PMID: 10663357
Doc-ID: 1045,

Clinical Studies

Comparison of bone parameters by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography in Hutterite vs. non-Hutterite women aged 35-60 years

A previous report of elevated dual-energy X-ray absorptiometry (DXA) bone mineral density (BMD) Z scores suggests that Hutterite females might be significantly less likely to develop osteoporosis compared with weiter...

Author: Wosje KS, Binkley TL, Specker BL
Source: Bone., 2001; 29(2): 192-7, PMID: 11502483
Doc-ID: 1046,

Clinical Studies

Medical Vibration Therapy in Osteopenic patients with Galileo900/2000

Author: Praet SFE, Mulder H, Snelder N
Source: Thesis, 2004;
Doc-ID: 993,
More information: Original Article
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Clinical Studies

Knochenmineralgehalt bei Kindern und Jugendlichen mit Hyperkalziurie

Author: B. Lettgen, P. Rasche Ch. Reiners
Source: Monatssch. Kinderheilkunde, 1995; 143: 46-49
Doc-ID: 973,

Clinical Studies

Influence of steroid medication on bone mineral density in children with nephrotic syndrome

Bone mineral density (BMD) was studied in 26 children with idiopathic nephrotic syndrome and in age- and sex-matched healthy controls. BMD was selectively measured in trabecular (TBD), cortical (CBD) and total weiter...

Author: Lettgen B, Jeken C, Reiners C
Source: Pediatr Nephrol., 1994; 8(6): 667-70, PMID: 7696102
Doc-ID: 976,

Clinical Studies

Bone mineral density in children and adolescents with juvenile diabetes: selective measurement of bone mineral density of trabecular and cortical bone using peripheral quantitative computed tomography

Bone mineral density (BMD) was studied in 21 children and adolescents with type I diabetes and in age- and sex-matched healthy controls. BMD was selectively measured in trabecular and total bone using periphera weiter...

Author: Lettgen B, Hauffa B, Möhlmann C, Jeken C, Reiners C
Source: Horm Res., 1995; 43(5): 173-5, PMID: 7782045
Doc-ID: 977,

Clinical Studies

Cortical mineral content of the radius assessed by peripheral QCT predicts compressive strength on biomechanical testing

Our aim was to evaluate the role of cortical bone in resistance to compression in the human radius. Thirty-three left cadaver forearms were scanned on an XCT 960 Stratec CT scanner. Cortical density and cortica weiter...

Author: Louis O, Boulpaep F, Willnecker J, Van den Winkel P, Osteaux M
Source: Bone., 1995; 16(3): 375-9, PMID: 7786641
Doc-ID: 978,

Clinical Studies

Multicenter German reference data base for peripheral quantitative computer tomography

The wide spread use of bone densitometers in Germany and other European countries has required the establishment of a validated reference population data base. A semianthropomorphic forearm cross-calibration ph weiter...

Author: Schneider P, Butz S, Allolio B, Börner W, Klein K, Lehmann R, Petermann K, Tysarczyk-Niemeyer G, Wüster C, Zander C, , et al
Source: Technol Health Care., 1995; 3(2): 69-73, PMID: 8574764
Doc-ID: 979,

Clinical Studies

Cortical thickness assessed by peripheral quantitative computed tomography: accuracy evaluated on radius specimens

The purpose of the present study was to evaluate the accuracy of peripheral quantitative computed tomography (pQCT) in measuring the thickness of the radial cortex. Thirty left forearm specimens were scanned on weiter...

Author: Louis O, Willnecker J, Soykens S, Van den Winkel P, Osteaux M
Source: Osteoporos Int., 1995; 5(6): 446-9, PMID: 8695966
Doc-ID: 980,

Clinical Studies

Knochendichte bei Kindern und Jugendlichen mit rheumatischen Erkrankungen. Vorläufige Ergebnisse einer Selektiven Messung von Spongiosa und Kortikalis mittels peripherer Computertomographie

(english) Selective measurements of bone mineral density (BMD) of trabecular and cortical bone at the ultradistal radius were made in 27 children with rheumatic diseases and in age- and sex-matched healthy con weiter...

Author: Lettgen B, Neudorf U, Hosse R, Peters S, Reiners C
Source: Klin Pädiatr, 1996; 208: 117-117
Doc-ID: 981,

Clinical Studies

Noninvasive bone strength index as analysed by peripheral quantitative computed tomography

Author: H. Schießl, J.L.Ferretti, G. Tysarczyk-Niemeyer & J. Willnecker
Source: Paediatric Osteology, 1996; 141-145
Doc-ID: 982,

Clinical Studies

Cortical and total bone mineral content of the radius: accuracy of peripheral computed tomography

The aim of the study was to evaluate the accuracy of an XCT 960 Stratec peripheral quantitative computed tomography (pQCT) device in assessing bone mineral content of the radius. We scanned 27 left forearm spec weiter...

Author: Louis O, Soykens S, Willnecker J, Van den Winkel P, Osteaux M
Source: Bone., 1996; 18(5): 467-72, PMID: 8739905
Doc-ID: 983,

Clinical Studies

Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell

Quantitative bone assessment today is primarily based on the analysis of bone mineral density (BMD). The geometric properties of bone, which are an important parameter for skeletal strength, are generally not c weiter...

Author: Augat P, Reeb H, Claes LE
Source: J Bone Miner Res., 1996; 11(9): 1356-63, PMID: 8864911
Doc-ID: 984,

Clinical Studies

Peripheral quantitative computed tomography: reference data and clinical experiences in chronic diseases

Author: Bernhard Lettgen
Source: Paediatric Osteology, 1996; 123-133
Doc-ID: 985,

Clinical Studies

Measurement of radial bone mineral density and cortical thickness in children by peripheral quantitative computed tomography

Author: De Schepper, De Boeck & O. Louis
Source: Paediatric osteology, 1996; 135-140
Doc-ID: 986,

Clinical Studies

Bone and muscle development during childhood in health and disease

Author: E. Schönau, E. Werhahn, U. Schiedermaier, E. Mokov, K. Scheidhauer, E. Rietschel, F. Haverkamp, H. Schießl & D. Michalk
Source: Paediatric osteology, 1996; 1996
Doc-ID: 987,

Clinical Studies

Comparison of trabecular bone density at vertebral and radial sites using quantitative computed tomography

Trabecular volumetric bone mineral density (VMD) was measured at the lumbar spine using quantitative computed tomography (QCT) and at the distal radius using peripheral QCT (pQCT) in 60 Japanese women aged 21-8 weiter...

Author: Fujii Y, Chikawa T, Nakamura T, Goto B, Fujita T
Source: Osteoporos Int., 1996; 6(6): 486-90, PMID: 9116395
Doc-ID: 988,

Clinical Studies

Quantitative computed tomography at the axial and peripheral skeleto

Author: Guglielmi G, Schneider P, Lang TF, Giannatempo GM, Cammisa M, Genant HK
Source: Eur Radiol., 1997; 7(10): 32-42, PMID: 9042764
Doc-ID: 989,

Clinical Studies

Quantitative assessment of experimental fracture repair by peripheral computed tomography

An experimental fracture model was used to assess bone mineral density at the fracture site by peripheral computed tomography and to compare the model with biomechanical, histological, and radiographic methods weiter...

Author: Augat P, Merk J, Genant HK, Claes L
Source: Calcif Tissue Int., 1997; 60(2): 194-9, PMID: 9056170
Doc-ID: 990,

Clinical Studies

Volumetric bone mineral density using peripheral quantitative computed tomography in Japanese women

The present study evaluated a commercial device for peripheral quantitative computed tomography (pQCT) and examined the age-related changes in normal Japanese women. The volumetric bone mineral density (vBMD) o weiter...

Author: Hasegawa Y, Kushida K, Yamazaki K, Inoue T
Source: Osteoporos Int., 1997; 7(3): 195-9, PMID: 9205630
Doc-ID: 991,

Clinical Studies

Nondestructive determination of iliac crest cancellous bone strength by pQCT

The close relationship between apparent bone density and compressive strength is well established. In clinical situations, histomorphometry and determination of the compressive strength on bone biopsies are des weiter...

Author: Ebbesen EN, Thomsen JS, Mosekilde L
Source: Bone., 1997; 21(6): 535-40, PMID: 9430244
Doc-ID: 992,

Clinical Studies

Änderung der Kraft und Stellenwert verschiedener Kraftmessmethoden bei älteren Frauen

Problemstellung: Der Verlust an Muskelkraft und -leistung ist bedeutsamer Risikofaktor für das erhöhte Sturz und Frakturrisiko im Alter. Die Erfassung der Muskelkraft/-leistung und des Muskelstatus spielt d weiter...

Author: Lammel C, Siegrist M, Zelger O, Jeschke D
Source: D. Zeitschrift Sportmed., Po-059, 2003; 54(7/8): 67
Keywords: elderly force
Doc-ID: 577,

Clinical Studies

Trainingsbedingte Anpassungen in der Knochengeometrie bei osteopenischen Frauen

Problemstellung: Knochen müssen sich in ihrer Festigkeit den einwirkenden Kräften anpassen, um physiologische Verformungen zu tolerieren. Neben der Knochenmasse und -dichte bestimmt die Knochengeometrie den weiter...

Author: Lammel C, Siegrist M, Zelger O, Jeschke D
Source: D. Zeitschrift Sportmed., KV-104, 2003; 54(7/8): 45
Doc-ID: 578,

Clinical Studies

Effect of vibration during fatiguing resistance exercise on subsequent muscle activity during maximal voluntary isometric contractions

This investigation was designed to determine if vibration during fatiguing resistance exercise would alter associated patterns of muscle activity. A cross-over design was employed with 8 subjects completing a r weiter...

Author: McBride JM, Porcari JP, Scheunke MD
Source: J Strength Cond Res., 2004; 18(4): 777-81, PMID: 15574082
Keywords: Galileo Dumbbell, Galileo Hantel, Vibrationshantel, vibrating Bumbbell
Doc-ID: 566,

Clinical Studies

Hormone and lipolytic responses to whole body vibration in young men

This study examined the effects of whole-body vibration (WBV) on the hormone and lipolytic responses. Eight male subjects performed WBV and control (CON) trials on separate days. The WBV session consisted of 10 weiter...

Author: Goto K, Takamatsu K
Source: Jpn J Physiol., 2005; 55(5): 279-84, PMID: 16271160
Doc-ID: 568,

Clinical Studies

Knee extensor fatigability after bedrest for 8 weeks with and without countermeasure

We analyzed the effects of gravitational unloading on muscular fatigability and the effectiveness of resistive vibration exercise to counteract these changes. Changes in knee extensor fatigability as a conseque weiter...

Author: Mulder ER, Kuebler WM, Gerrits KH, Rittweger J, Felsenberg D, Stegeman DF, De Haan A
Source: Muscle Nerve., 2007; 36(6): 798-806, PMID: 17661376
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 571,

Clinical Studies

Effects of vibration exercise on muscle performance and mobility in an older population

This study was designed to investigate the effects of vibration on muscle performance and mobility in a healthy, untrained, older population. Forty-three participants (23 men, 20 women, 66-85 y old) performed t weiter...

Author: Rees S, Murphy A, Watsford M
Source: J Aging Phys Act., 2007; 15(4): 367-81, PMID: 18048942
Keywords: elderly mobility
Doc-ID: 573,

Clinical Studies

Highly demanding resistive vibration exercise program is tolerated during 56 days of strict bed-rest.

Several studies have tried to find countermeasures against musculoskeletal de-conditioning during bed-rest, but none of them yielded decisive results. We hypothesised that resistive vibration exercise (RVE) mig weiter...

Author: Rittweger J, Belavy D, Hunek P, Gast U, Boerst H, Feilcke B, Armbrecht G, Mulder E, Schubert H, Richardson C, de Haan A, Stegeman DF, Schiessl H, Felsenberg D
Source: Int J Sports Med, 2006; 27(7): 553-9, PMID: 16802251
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 291,

Clinical Studies

Variation in neuromuscular responses during acute whole-body vibration exercise

PURPOSE: Leg muscle strength and power are increased after whole-body vibration (WBV) exercise. These effects may result from increased neuromuscular activation during WBV; however, previous studies of neuromus weiter...

Author: Abercromby AF, Amonette WE, Layne CS, McFarlin BK, Hinman MR, Paloski WH
Source: Med Sci Sports Exerc., 2007; 39(9): 1642-50, PMID: 17805098
Doc-ID: 305,

Clinical Studies

Low-frequency vibratory exercise reduces the risk of bone fracture more than walking: a randomized controlled trial

BACKGROUND: Whole-body vibration (WBV) is a new type of exercise that has been increasingly tested for the ability to prevent bone fractures and osteoporosis in frail people. There are two currently marketed weiter...

Author: Gusi N, Raimundo A, Leal A
Source: BMC Musculoskelet Disord., 2006; 7: 92, PMID: 17137514
Keywords: Knochenzuwchacs
Doc-ID: 338,
More information: Original Article

Clinical Studies

Krafttraining unter Vibrationseinwirkung

In der vorliegenden Untersuchung sollten die Auswirkungen eines vibrationsgestützten Krafttrainings auf das Maximal- und Explosivkraftverhalten überprüft und mit den Effekten einer herkömmlichen Krafttraini weiter...

Author: Schlumberger A, Salin D, Schmidtbleicher D
Source: Sportverletz Sportschaden, 2001; 15: 1-7, PMID: 11338657
Doc-ID: 447,

Clinical Studies

USE OF VIBRATION-ASSISTED EXERCISE IN FIBROMYALGIA PATIENTS

Objectve: Vibratory-assisted exercise is a relatively new concept in the US; however, there is supportive research in Europe indicating its effectiveness on athletes and the general population through providi weiter...

Author: Wayloins G, Todd C, Danko M, Le V.
Source: 2005;
Doc-ID: 499,

Clinical Studies

Effects of acute upper-body vibration on strength and power variables in climbers

Whole-body vibration training has recently received a lot of attention with reported enhancements of strength and power qualities in athletes. This study investigated whether upper-body vibration would be able weiter...

Author: Cochrane DJ, Hawke EJ
Source: J Strength Cond Res., 2007; 21(2): 527-31, PMID: 17530943
Keywords: Galileo Dumbbell, Galileo Hantel, Vibrationshantel, vibrating Bumbbell
Doc-ID: 549,

Clinical Studies

Metabolic and Cardiovascular response during Whole Body Vibration (WBV) Exercise - a Pilot Study

WBV is an exercise modality touted for its improvement of neuromuscular and skeletal function. Little is known about the psychological and physiological strain of WBV exercise and their influence on exercise co weiter...

Author: Mark A, MacDonald M, Rakobowchuck M, Gordon C, Blimke M
Source: Poster, 2005;
Doc-ID: 23,

Clinical Studies

Ergebnisse einer monozentrischen Studie zur Verbesserung der Mobilität und Muskelfunktion bei Kindern und Jugendlichen mit Osteogenesis Imperfecta

Author: Schönau E, Neu CM, Mokov E, Wassmer G, Manz F
Source: 1. Kölner Symposium: Forschung in der pädiatrischen Physiotherapie, 2007;
Keywords: Kölner Konzept
Doc-ID: 293,
Download:

Clinical Studies

Motor rehabilitation of spinal cord dysfunction by means of whole body vibration

Objective: To explore (1) the efficacy of whole body vibration (WBV) in inducing reflex standing and, specifically, (2) the progress of persons with spinal cord dysfunction of 3 differing etiologies. Desi weiter...

Author: Gianutsos JG, Oakes LC, Siasoco V, Appelblatt S, Hamel J, Gold JT
Source: AAPMR, 2001;
Keywords: back
Doc-ID: 372,

Clinical Studies

Use of a Therapeutic Ranging/Exercise Program in the Rehabilitation of a Person with Progressive Supranuclear Palsy

Author: Gianutsos JG
Source: 3rd Mediterranean Conference of Physical Medicine and rehabilitation, 2000;
Keywords: parkinson
Doc-ID: 373,
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Clinical Studies

The Benefits of Whole Body Vibration in the Rehabilitation of a Pediatric Patient with Quadriplegia

A 73-year-old male diagnosed six years earlier was advanced Progressive Supranuclear Palsy (PSP), an atypical form of Parkinsonism, had deteriorated over several months despite attemps to adjust medication. He weiter...

Author: Gianutsos JG, Ahn JH, Oakes LV, Richter EF, Grynbaum BB, Thistle HG
Source: 3RD MEDITERRANEAN CONGRESS of Physical Medicine and Rehabilitation, Athens, 2000;
Doc-ID: 392,

Clinical Studies

Use of a Therapeutic Ranging Program in the Rehabilitation of a Person wirth Progressive Supranuclear Palsy (Parkinson)

Author: Gianutsos JG, Richter EF, Hutchinson M
Source: 5th International Congress of Physical Medicine and Rehabilitation, Athens, 2000;
Keywords: Parkinson
Doc-ID: 188,
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Clinical Studies

The Effects of Whole Body Vibration on Reflex-Induced Standing in Persons with Chronic and Acute Spinal Cord Injury

Author: Gianutsos JG, Ahn JH, Richter EF, Grynbaum BB, Thistle HG
Source: 5th International Congress of Physical Medicine and Rehabilitation, Athens, 2000;
Doc-ID: 189,
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Clinical Studies

Acute whole body vibration training increases vertical jump and flexibility performance in elite female field hockey players

OBJECTIVE: To quantify the acute effect of whole body vibration (WBV) training on arm countermovement vertical jump (ACMVJ), grip strength, and flexibility performance. METHODS: Eighteen female elite fiel weiter...

Author: Cochrane DJ, Stannard SR
Source: Br J Sports Med., 2005; 39(11): 860-5, PMID: 16244199
Doc-ID: 281,

Clinical Studies

Effect of whole-body vibration exercise on lumbar bone mineral density, bone turnover, and chronic back pain in post-menopausal osteoporotic women treated with alendronate

BACKGROUND AND AIMS: Exercise may enhance the effect of alendronate on bone mineral density (BMD) and reduce chronic back pain in elderly women with osteoporosis. The aim of this study was to determine whether weiter...

Author: Iwamoto J, Takeda T, Sato Y, Uzawa M
Source: Aging Clin Exp Res., 2005; 17(2): 157-63, PMID: 15977465
Keywords: Bone, Back Pain
Doc-ID: 282,

Clinical Studies

Effect On Muscles Of Mechanical Vibrations Produced By The Galileo 2000 in Combionation with Physical Therapy in Treaining Female Stress Urinary Incontinence

Author: von der Heide S, Emons G, Hilgers R, Viereck V
Source: international urology conference, 2003;
Doc-ID: 349,
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Clinical Studies

Bewertung verschiedener Trainingsformen zur Prävention der Osteoporose anhand struktureller Anpassungen des Knochens und der Änderungen des Muskelstatus bei postmenopausalen Frauen

Problemstellung: Um alltägliche, physiologische Verformungen zu tolerieren, müssen sich Knochen in ihrer Festigkeit den einwirkenden Zug- und Druckspannungen anpassen. Auf Makroebene ist die Knochenfestigke weiter...

Author: Lammel C
Source: Dissertation,, 2004;
Keywords: elderly power
Doc-ID: 398,
More information: Original Article

Clinical Studies

The short-term effect of whole-body vibration training on vertical jump, sprint, and agility performance

Previous studies have suggested that short-term whole-body vibration (WBV) training produces neuromuscular improvement similar to that of power and strength training. However, it is yet to be determined whether weiter...

Author: Cochrane DJ, Legg SJ, Hooker MJ
Source: J Strength Cond Res., 2004; 18(4): 828-32, PMID: 15574090
Doc-ID: 448,

Clinical Studies

Muscle stiffness and injury effects of whole body vibration

Objective: The interest in vibration as a method of enhancing muscular performance is receiving considerable attention from sport scientists, physiotherapists, coaches and athletes. Increases in strength, powe weiter...

Author: Cronin, JB, Olivera M, McNairb PJ
Source: Physical Therapy in Sport, 2004; 5/2: 68-74
Doc-ID: 449,

Clinical Studies

Bone-Strength-Index for the description of setpoint changes of bone remodeling

Author: Hartard M, Schiessl H, Arians A, Jeschke D
Source: Int J Sports Med, 2002; 23 Suppl. 2: 154
Keywords: HRT
Doc-ID: 457,

Clinical Studies

Controlled Whole Body Vibration to decrease Fall Risk and improve health-related Quality of Life of Nursing Home Residents

OBJECTIVE: To investigate the effects of whole body vibration in the elderly. DESIGN: Randomized controlled trial. SETTING: Nursing home. PARTICIPANTS: Forty-two elderly volunteers. INTERVENTION weiter...

Author: Bruyere O, Wuidart MA, Di Palma E, Gourlay M, Ethgen O, Richy F, Reginster JY
Source: Arch Phys Med Rehabil., 2005; 86(2): 303-7, PMID: 15706558
Keywords: elderly
Doc-ID: 272,

Clinical Studies

Acute Effects of Whole-Body Vibration on Lower Body Flexibility and Strength

Whole-body vibration (WBV) is a neuromuscular training method designed to improve muscle strength and mobility that has become an increasing popular mode of alternative training in European athletes. Purpose: weiter...

Author: Burns PA, Beekhuizen KS, Jacobs PL
Source: Medicine & Science in Sports & Exercise, 2004; 36(5):
Doc-ID: 370,
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Clinical Studies

Neuromuscular Responses to Two Whole-Body Vibration Modalities During Dynamic Squats

INTRODUCTION: Whole Body Vibration (WBV) is a method used to stimulate skeletal muscle reflexes and has been shown to elicit training responses in muscle strength and power. PURPOSE: The purpose of this st weiter...

Author: Amonette WE, Abercromby AFJ, Hinman M, Paloski WH
Source: NSCA National Conference and Exposition, 2005;
Keywords: Galileo vs. Powerplate
Doc-ID: 376,

Clinical Studies

Positive Bilanz endostalen Remodelings unter maximaler muskulärer Koaktivierung bei postmenopausalen Frauen

Problemstellung: Positive Zusammenhänge zwischen der Knochenfestigkeit und der Maximalkraft gelten ebenso gesichert wie zwischen Krafttraining und Knochenmassenentwicklung (BMD). Ein neues Trainingsgerätesys weiter...

Author: Lammel C, Hartard M, Siegrist M, Schiessl H, Jeschke D
Source: 37. Deutscher Kongresses für Sportmedizin und Prävention, Rotenburd a.d. Fulda, 2001;
Doc-ID: 393,
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Clinical Studies

Einfluss einer neuen Form des Krafttrainings auf kardiopulmonale und muskuläre Funktionsgrössen sowie sympathoadrenerge Reaktionen

Problemstellung: Für die neuromuskuläre Erregbarkeit und die lokalmuskuläre Hämodynamik konnten positive Effekte nach einer oszillierenden Intervention (Amplitude von 12 mm, 25-30 Hz) mit einem neuen Train weiter...

Author: Wameling P, Hartard M, Kleinmond C, Schiessl H, Jeschke D
Source: 37. Deutscher Kongresses für Sportmedizin und Prävention, Rotenburg a.d. Fulda, 2001;
Doc-ID: 394,
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Clinical Studies

Einfluss eines intensiven Krafttrainings auf Parameter von Knochen-stoffwechsel und Hormonstatus von postmenopausalen Frauen

Problemstellung: Knochenmarker ermöglichen die Beschreibung kurzfristiger Anpassungsreaktionen des Knochenstoffwechsels. Ziel dieser Studie war, den Verlauf dieser Marker und den Hormonstatus bei postmenopau weiter...

Author: Kleinmond C, Hartard M, Haas W, Zelger O, Jeschke D
Source: 37. Deutscher Kongresses für Sportmedizin und Prävention, Rotenburg a.d. Fulda, 2001;
Doc-ID: 395,
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Clinical Studies

Krafttraining an konventionellen bzw. oszillierenden Geräten und Wirbelsäulengymnastik in der Prävention der Osteoporose bei postmenopausalen Frauen

In einer 12-monatigen prospektiven, randomisierten und kontrollierten Studie an 69 osteopenischen, postmenopausalen Frauen wurden die Effekte verschiedener Trainingsprogramme auf Knochen, Muskelkraft, dynamisch weiter...

Author: Siegrist M, Lammel C, Jeschke D
Source: DEUTSCHE ZEITSCHRIFT FÜR SPORTMEDIZIN, 2006; 57/7-8: 182-188
Keywords: elderly osteo
Doc-ID: 396,
More information: Original Article

Clinical Studies

Long-term effects of 6-week whole-body vibration on balance recovery and activities of daily living in the postacute phase of stroke: a randomized, controlled trial

BACKGROUND AND PURPOSE: The long-term effects of 6-weeks whole-body vibration, as a novel method of somatosensory stimulation, on postural control and activities of daily living were compared with those of 6 weiter...

Author: van Nes IJ, Latour H, Schils F, Meijer R, van Kuijk A, Geurts AC
Source: Stroke., 2006; 37(9): 2331-5, PMID: 16902175
Keywords: supratentorial stroke
Doc-ID: 397,
More information: Original Article

Clinical Studies

Stellenwert verschiedener Trainingsprogramme in der Prävention der Osteoporose

In einer prospektiven, kontrollierten und randomisierten Studie über 12 Monate an 69 gesunden postmenopausalen osteopenischen Frauen wurden die Auswirkungen verschiedener Trainingsprogramme auf Knochenstoffwec weiter...

Author: Siegrist M
Source: Dissertation, Technische Universität München , Fakultät für Sportwissenschaften, 2003;
Keywords: elderly osteo
Doc-ID: 399,
More information: Original Article

Clinical Studies

Randomisierter Vergleich von zwei Formen des Krafttrainings zur Prävention des Osteoporeose

Einleitung Ein neues Trainingsgerätesystem -Galileo 2000- ermöglicht die Durchführung eines konventionellen dynamischen Krafttrainings unter zeitgleich hochfrequenter mechanischer Oszillation. Uns stellte s weiter...

Author: Hartard M, Häring S, Schwaiger M, Bottermann P, Kowolik J, Schießl H, Kleinmond C, Jeschke D
Source: International Journal of Sports Medicine, 2002; 154
Doc-ID: 400,
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Clinical Studies

Einfluss einer neuen Form des Krafttrainings im Vergleich und in Kombination mit einer Hormonersatztherapie auf die Knochenmassen

Problemstellung: Positive Zusammenhänge zw. einem Krafttraining und der Knochenmassenentwicklung (BMD) gelten als gesichert. Ein neues Trainingsgerätesystem (GALILEO 2000) ermöglicht die Intensivierung des weiter...

Author: Hartard M, Schiessl H, Kleinmond C, Lindbüchl S, Jeschke D
Source: 37. Deutscher Kongresses für Sportmedizin und Prävention, Rotenburg a.d. Fulda, 2001;
Keywords: HRT
Doc-ID: 401,
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Clinical Studies

Status der Maximalkraft vor und nach oszillierender Intervention

Problemstellung: Für die neuromuskuläre Erregbarkeit und die lokalmuskuläre Hämodynamik konnten positive Effekte nach einer oszillierenden Intervention (Amplitude von 12mm, 25-30Hz) mit einem neuen Traini weiter...

Author: Lammel C, Hartard M, Kleinmond C, Schiessl H, Jeschke D
Source: Dtsch Z Sportme, 1999; 50/20:
Keywords: Galileo Dumbbell, Galileo Hantel, Vibrationshantel, vibrating Bumbbell
Doc-ID: 402,
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Clinical Studies

Vibrationskrafttraining und Gelenkstabilität: EMG-Untersuchungen zur Wirkung von Vibrationsfrequenz und Körperhaltung auf Muskelaktivierung und -koaktivierung

Das Ziel dieser Studie war es, im Rahmen einer elektromyographischen Untersuchung zu überprüfen, wie sich die EMG-Aktivität von Agonist und Antagonist beim Training auf einer Vibrationsplattform in Abhängig weiter...

Author: Berschin G, Sommer HM
Source: DEUTSCHE ZEITSCHRIFT FÜR SPORTMEDIZIN, 2004; 55/6: 152-156
Doc-ID: 405,
More information: Original Article

Clinical Studies

Zur Bedeutung der Körperhaltung beim Training auf Vibrationsplattformen

Das Training auf Vibrationsplattformen gilt als eine neue effiziente Trainingsform, die sowohl im Sport als auch in der Rehabilitation verwendet wird. In eigenen Studien wurde nachgewiesen, dass die Körperhalt weiter...

Author: Berschin G, Fischer H, Sommer HM
Source: Z. f. Physiotherapeuten, 2006; 58/3: 208-212
Keywords: Körperhaltung auf Galileo
Doc-ID: 407,

Clinical Studies

Acute Effects of Whole-Body Vibration on Soleus H-Reflex

Introduction: Recent investigations suggest that whole-body vibration (WBV) training contributes to enhanced athletic performance2,4 and improvement in functional ability in individuals with disabilities1,3, y weiter...

Author: Beekhuizen KS, Field-Fote EC, Burns PA, Jacobs PL
Source: Medicine & Science in Sports & Exercise, 2004; 36(5):
Keywords: H-Reflex
Doc-ID: 432,

Clinical Studies

Recovery Effects of GALILEO 2000 - A New Device for Training-Investigations

Purpose: In this study, we investigated a new device for muscle training and recovery called Galileo 2000 (Novotec, Fig.5) which included exertion with superimposed vibratory stimulation (VS). . Study Design weiter...

Author: Harthard H, Kleinmond C, Lammel C, Schießl H, Jeschke D
Source: International Course on Osteoporosis; Vienna, 1999;
Keywords: Recovery
Doc-ID: 185,
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Clinical Studies

Long Term effects of GALILEO 2000 - a new training device

Author: S. Häring, M. Hartard, M. Schlitter, P. Bartenstein, H. Schießl, D. Jeschke
Source: International Course on Osteoporosis, 2000;
Keywords: Bone Strength
Doc-ID: 193,
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Clinical Studies

Langzeiteffekte des GALILEO 2000

Problemstellung: Ein neues Trainingsgerätesystem (Galileo 900 - 2000 ) ermöglicht eine Modifikation des konventionellen dynamischen Krafttrainings ( KRAFT). Ziel dieser Studie war daher der Vergleich von KR weiter...

Author: Schlitter M, Hartard M, Häring S, Bartenstein P, Schießl H, Jeschke D
Source: International Course on Osteoporosis; Vienna, 1999;
Keywords: Galileo Dumbbell, Galileo Hantel, Vibrationshantel, vibrating Bumbbell
Doc-ID: 207,
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Clinical Studies

Einfluss mechanischer Schwingungen auf die Beckenbodenmuskulatur mittels GALILEO 2000 in Kombination mit Physiotherapie zur Behandlung der weiblicher Stressinkontinenz

Author: von der Heide S, Hilgers R, Viereck V, Emons D
Source: Proceedings of the International Continence Society,33rd Annual Meeting, Florence, 2003;
Doc-ID: 262,
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Clinical Studies

Zum Einsatz von Vibrationstraining als spezifisches Schnellkrafttrainingsmittel in Sportspielen - am Beispiel Rugby

Author: Berschin G, Schmiedeberg I, Sommer HM
Source: Leistungssport, 2003; 4:
Doc-ID: 263,

Clinical Studies

Zum Einsatz von Vibrationskrafttraining in der Rehabilitation nach VKB-Rekonstruktion

Author: Berschin G, Behrens A, Sommer HM
Source: Deutsche Zeitschrift für Sportmedizin, 2005; 56: Poster 319:
Keywords: bänder
Doc-ID: 279,
More information: Original Article
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Clinical Studies

High-frequency whole-body vibration improves balancing ability in elderly women

OBJECTIVE: To investigate the efficacy of high-frequency whole-body vibration (WBV) on balancing ability in elderly women. DESIGN: Randomized controlled trial. Subjects were randomized to either the WBV interve weiter...

Author: Cheung WH, Mok HW, Qin L, Sze PC, Lee KM, Leung KS
Source: Arch Phys Med Rehabil., 2007; 88(7): 852-7, PMID: 17601464
Keywords: elderly balance
Doc-ID: 346,

Clinical Studies

Effects of vibration and resistance training on neuromuscular and hormonal measures

The aim was to study whether whole body vibration (WBV) combined with conventional resistance training (CRT) induces a higher increase in neuromuscular and hormonal measures compared with CRT or WBV, respective weiter...

Author: Kvorning T, Bagger M, Caserotti P, Madsen K
Source: Eur J Appl Physiol., 2006; 96(5): 615-25, PMID: 16482475
Doc-ID: 347,

Clinical Studies

Effect of Whole Body Vibration on Muscular Performance, Balance, and Bone

Author: Torvinen S
Source: Dissertation, 2003;
Keywords: Galileo vs. Kuntotäry
Doc-ID: 353,
More information: Original Article

Clinical Studies

Correlation of Strength Strain Index (SSI) and Torque in Upper Limbs

Author: Hartard M, Horn D, Bartenstein P, Schießl H
Source: 2000;
Doc-ID: 358,
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Clinical Studies

Controlled Whole Body Vibrations Improve Health Related Quality Of Life In Elderly Patients

Objective: To investigate the effects of controlled whole body vibrations (CWBV) exercises on global health in elderly patients. Methods: 42 volunteers patients, resident in a nursing home, were randomiz weiter...

Author: Bruyere O, Wuidart MA, Di Palma E, Reginster JY
Source: 2003;
Doc-ID: 368,

Clinical Studies

Influence of vibration on mechanical power and electromyogram activity in human arm flexor muscles

The aim of this study was to evaluate the influence of vibration on the mechanical properties of arm flexors. A group of 12 international level boxers, all members of the Italian national team, voluntarily part weiter...

Author: Bosco C, Cardinale M, Tsarpela O
Source: Eur J Appl Physiol Occup Physiol., 1999; 79(4): 306-11, PMID: 10090628
Keywords: Galileo Dumbbell, Galileo Hantel, Vibrationshantel, vibrating Bumbbell
Doc-ID: 371,

Clinical Studies

Short-term effects of whole-body vibration on maximal voluntary isometric knee extensor force and rate of force rise

Whole-Body vibration (WBV) may lead to muscle contractions via reflex activation of the primary muscle spindle (Ia) fibres. WBV has been reported to increase muscle power in the short term by improved muscle ac weiter...

Author: de Ruiter CJ, van der Linden RM, van der Zijden MJ, Hollander AP, de Haan A
Source: Eur J Appl Physiol., 2003; 88(4-5): 472-5, PMID: 12527980
Doc-ID: 385,

Clinical Studies

The effect of weight-bearing exercise with low frequency, whole body vibration on lumbosacral proprioception: a pilot study on normal subjects

Patients with low back pain (LBP) often present with impaired proprioception of the lumbopelvic region. For this reason, proprioception training usually forms part of the rehabilitation protocols. New exercise weiter...

Author: Fontana TL, Richardson CA, Stanton WR
Source: Aust J Physiother., 2005; 51(4): 259-63, PMID: 16321133
Doc-ID: 386,

Clinical Studies

The Influence of Whole Body Vibration on Jumping Performance

Physical exercise is recommended for the prevention and treatment of osteoporosis. However, its exact role and effectiveness in adulthood is unclear. While vigorous exercise of long duration enhances bone densi weiter...

Author: Bosco C, Cardinale M, Tsarpela O, Colli R, Tihanyi J, Ducillard C, Viru A
Source: Biology of Sport, 1998; 15/3: 157-164
Doc-ID: 167,

Clinical Studies

Acute changes in neuromuscular excitability after exhaustive whole body vibration exercise as compared to exhaustion by squatting exercise

The effects of hard squatting exercise with (VbX+) and without (VbX-) vibration on neuromuscular function were tested in 19 healthy young volunteers. Before and after the exercise, three different tests were pe weiter...

Author: Rittweger J, Mutschelknauss M, Felsenberg D
Source: Clin Physiol Funct Imaging., 2003; 23(2): 81-6, PMID: 12641601
Doc-ID: 261,

Clinical Studies

Short-term effects of whole-body vibration on postural control in unilateral chronic stroke patients: preliminary evidence

The short-term effects of whole-body vibration as a novel method of somatosensory stimulation on postural control were investigated in 23 chronic stroke patients. While standing on a commercial platform, patien weiter...

Author: van Nes IJ, Geurts AC, Hendricks HT, Duysens J
Source: Am J Phys Med Rehabil., 2004; 83(11): 867-73, PMID: 15502741
Keywords: stroke
Doc-ID: 273,

Clinical Studies

Controlled Whole body vibrations to decrease fall risk and improve health related quality of life in elderly patients

Objective: To investigate the effects of controlled whole body vibrations (CWBV) exercises on global health in elderly patients. Methods: 42 volunteers patients, resident in a nursing home, were randomiz weiter...

Author: Bruyere O, Wuidart M, Di Palma E, Gourlay M, Ethgen O, Richy F, Reginster J
Source: 2003;
Doc-ID: 28,
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Clinical Studies

The effects of vibration on human performance and hormonal profile

Author: Cardinale M
Source: Abstract Dissertation, 2002;
Doc-ID: 333,

Clinical Studies

Einfluss mechanischer oszillierender Stimuli im Rahmen der frühfunktionellen Aktivierung des propiozeptiven Systems auf die Oberschenkelmuskulatur nach Rekonstruktion des vorderen Kreuzbandes des Kniegelenkes

Im Rahmen dieser Studie wurde ergänzend zu den „allgemeinen“ rehabilitativen Maßnahmen der Einfluß mechanischer Stimuli mittels oszillierender Interventionen vom Galileo 2000 auf die berschenkelmuskulat weiter...

Author: Kombrink M
Source: Dissertation, 2006;
Keywords: kreuzband kniegelenk
Doc-ID: 334,
More information: Original Article

Clinical Studies

Zusammenhänge zwischen Knochendichte, Knochenmasse, Knochenfestigkeit des Radius und dem maximalen Drehmoment der Unterarmbeugemuskulatur

Klinisch bedeutsame Veränderungen des Knochenstatus resultieren meist in einer Verminderung der Knochendichte bis hin zu einer manifesten Osteoporose. Heutzutage werden zur Überprüfung des Knochenstatus häu weiter...

Author: Wolf D
Source: 2003;
Keywords: Zusammenhang SSI, Muskelkraft / Drehmoment
Doc-ID: 335,
More information: Original Article

Clinical Studies

Projekt Fit & Sail - Pilotstudie: Vergleich der Wirkungen von Vibrationstraining und Fahrtensegeln auf die Sprungkraft

Im Rahmen des Forschungsprojektes "Fit & Sail" zur Untersuchung der körperlichen und mentalen Leistungen und Belastungen älterer Segler auf Fahrtensegelbooten in Zusammenarbeit mit dem Bundesverband Wasserspo weiter...

Author: Mell WD
Source: IBoaT-Report, 2006; 3.2:
Doc-ID: 336,

Clinical Studies

Gravitational forces and whole body vibration: implications for prescription of vibratory stimulation

The purpose of this study was to determine the gravitational forces (g-forces) associated with different postures (standing single leg, standing double leg, semi-squat), amplitudes (1.25, 3.0, 5.25 mm), frequen weiter...

Author: Crewther B, Cronin J, Keogh J
Source: Physical Therapy in Sport, 2003; 5/1: 37-43
Keywords: Galileo Acceleration
Doc-ID: 337,

Clinical Studies

Mechanical impacts to the human body by different vibration training devices

Author: Spitzenpfeil P, Stritzker M, Kirchbichler A, Tusker F, Hartmann U, Hartard H
Source: Journal of Biomechanics, 2006; Vol. 39 (Suppl 1): 196
Keywords: Galileo vs. Power Plate
Doc-ID: 339,

Clinical Studies

EFFECT OF KNEE FLEXION ANGLE ON NEUROMUSCULAR RESPONSES TO WHOLE-BODY VIBRATION

Author: Abercromby A, Amonette W, Paloski W, Hinman M
Source: Presented Abstract at NSCA National Conference, 2005;
Doc-ID: 344,
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Clinical Studies

Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin Bed Rest study

Deconditioning is a risk factor for cardiovascular disease. The physiology of vascular adaptation to deconditioning has not been elucidated. The purpose of the present study was to assess the effects of bed res weiter...

Author: Bleeker MW, De Groot PC, Rongen GA, Rittweger J, Felsenberg D, Smits P, Hopman MT
Source: J Appl Physiol., 2005; 99(4): 1293-300, PMID: 15932956
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 283,

Clinical Studies

Human skeletal muscle structure and function preserved by vibration muscle exercise following 55 days of bed rest

Prolonged immobilization of the human body results in functional impairments and musculoskeletal system deconditioning that may be attenuated by adequate muscle exercise. In a 56-day horizontal bed rest campaig weiter...

Author: Blottner D, Salanova M, Püttmann B, Schiffl G, Felsenberg D, Buehring B, Rittweger J
Source: Eur J Appl Physiol., 2006; 97(3): 261-71, PMID: 16568340
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 284,

Clinical Studies

Krafttraining mit dem Galileo2000 im Jugendbereich

Spätestens seit Mitte der 80er Jahre hat man erkannt, dass in den führenden Sportnationen und in den meisten olympischen Sportarten die Ausweitung der Trainingsumfänge nicht länger eine Hauptreserve für w weiter...

Author: Harbrecht E
Source: 2003;
Keywords: Volleyball
Doc-ID: 285,
More information: Original Article
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Clinical Studies

Resistive Vibration Exercise Prevents Bone Loss During 8 Weeks of Strict Bed Rest in Healthy Male Subjects: Results from the Berlin Bed Rest (BBR) Study

Resistive vibration exercise, as applied here, appears to completely prevent bone loss from the tibia during prolonged bed rest," conclude the study authors, Dr Dieter Felsenberg (Manchester University, UK) and weiter...

Author: Rittweger J, Felsenberg D
Source: 26th Annual Meeting of the American Society for Bone and Mineral Research, 2004; Poster 1145:
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 290,
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Clinical Studies

Weight training with the Galileo2000 in youth top-volleyball

Author: Harbrecht E
Source: Thesis University Berlin (translated summary), 2002;
Keywords: Volleyball
Doc-ID: 292,
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Clinical Studies

Preliminary results on the mobility after whole body vibration in immobilized children and adolescents

The present article is a preliminary report on the effect of Whole Body Vibration (WBV) on the mobility in long-term immobilized children and adolescents. WBV was applied to 6 children and adolescents (diagnose weiter...

Author: Semler O, Fricke O, Vezyroglou K, Stark C, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2007; 7(1): 77-81, PMID: 17396011
Keywords: Kölner Konzept
Doc-ID: 296,
More information: Original Article

Clinical Studies

Submaximal aerobic exercise with mechanical vibrations improves the functional status of patients with chronic fatigue syndrome

AIM: Chronic fatigue syndrome (CFS) is an illness characterised by disabling fatigue of uncertain aetiology and other nonspecific symptoms. Typically CFS patients complain of a severe fatigue made worse by ex weiter...

Author: Saggini R, Vecchiet J, Iezzi S, Racciatti D, Affaitati G, Bellomo RG, Pizzigallo E
Source: Eura Medicophys., 2006; 42(2): 97-102, PMID: 16767057
Doc-ID: 298,

Clinical Studies

Strength, size and activation of knee extensors followed during 8 weeks of horizontal bed rest and the influence of a countermeasure

Changes in the quadriceps femoris muscle with respect to anatomical cross sectional area (CSA), neural activation level and muscle strength were determined in 18 healthy men subjected to 8 weeks of horizontal b weiter...

Author: Mulder ER, Stegeman DF, Gerrits KH, Paalman MI, Rittweger J, Felsenberg D, de Haan A
Source: Eur J Appl Physiol., 2006; 97(6): 706-15, PMID: 16786354
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 301,

Clinical Studies

Determinants of musculoskeletal frailty and the risk of falls in old age

Neuromuscular parameters that describe locomotion are indispensable variables for the diagnosis and treatment of frailty, fall risk and osteoporosis. A scientifically-based standardized locomotor assessment sho weiter...

Author: Runge M, Hunter G
Source: J Musculoskelet Neuronal Interact., 2006; 6(2): 167-73, PMID: 16849828
Keywords: Mechanography
Doc-ID: 303,
More information: Original Article

Clinical Studies

Mechanography--a new device for the assessment of muscle function in pediatrics

The development of the musculoskeletal system in children and adolescents became an important topic in the field of pediatric research when the connections between muscle force and bone diseases were revealed. weiter...

Author: Fricke O, Weidler J, Tutlewski B, Schoenau E
Source: Pediatr Res., 2006; 59(1): 46-9, PMID: 16327004
Keywords: Mechanography
Doc-ID: 304,

Clinical Studies

Die Ergebnisse Berliner BedRest-Studie

Author: Felsenberg D
Source: Statement, 2004;
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
Doc-ID: 311,
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Clinical Studies

Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia

Sarcopenia, the reduction of muscle mass and strength that occurs with aging, is widely considered one of the major causes of disability in older persons. Surprisingly, criteria that may help a clinician to ide weiter...

Author: Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, Rantanen T, Guralnik JM, Ferrucci L
Source: J Appl Physiol., 2003; 95(5): 1851-60, PMID: 14555665
Doc-ID: 1755,

Clinical Studies

Vibration exposure and biodynamic responses during whole-body vibration training

PURPOSE: Excessive, chronic whole-body vibration (WBV) has a number of negative side effects on the human body, including disorders of the skeletal, digestive, reproductive, visual, and vestibular systems. Whol weiter...

Author: Abercromby AF, Amonette WE, Layne CS, McFarlin BK, Hinman MR, Paloski WH
Source: Med Sci Sports Exerc., 2007; 39(10): 1794-800, PMID: 17909407
Keywords: Galileo vs. Power Plate
Doc-ID: 169,

Clinical Studies

Oxygen uptake in whole-body vibration exercise: influence of vibration frequency, amplitude, and external load

Vibration exercise (VbX) is a new type of physical training to increase muscle power. The present study was designed to assess the influence of whole-body VbX on metabolic power. Specific oxygen uptake (sVO(2)) weiter...

Author: Rittweger J, Ehrig J, Just K, Mutschelknauss M, Kirsch KA, Felsenberg D
Source: Int J Sports Med., 2002; 23(6): 428-32, PMID: 12215962
Doc-ID: 264,

Clinical Studies

Safety of Whole-Body Vibration Exercise for Heart Transplant Recipients

Purpose: The benefits of whole-body vibration exercise (WBV) have not yet been recognized in heart transplant recipients although these patients often show a severe loss in skeletal muscle strength and bone min weiter...

Author: Crevenna R, Fialka-Moser V, Rödler S, Keilani M, Zöch C, Nuhr M, Quittan M, Wolzt M
Source: Phys Rehab Kur Med, 2003; 13: 286-290
Keywords: heart transplant
Doc-ID: 266,

Clinical Studies

Reproducibility of the jumping mechanography as a test of mechanical power output in physically competent adult and elderly subjects

OBJECTIVES: To compare the reproducibility of the newly developed jumping mechanography with other physical tests. DESIGN: Study 1: Repeated testing with an interval of 2 weeks to assess the short-term repetiti weiter...

Author: Rittweger J, Schiessl H, Felsenberg D, Runge M
Source: J Am Geriatr Soc., 2004; 52(1): 128-31, PMID: 14687327
Keywords: Mechanography
Doc-ID: 270,

Clinical Studies

Multifactorial pathogenesis of falls as a basis for multifactorial interventions

Author: Runge M, Schacht E
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 127-34, PMID: 15951628
Keywords: Mechanography
Doc-ID: 275,
More information: Original Article

Clinical Studies

Sicherheit und Leistungsoptimierung im Vibrationstraining

Zusammenfassung Der Beitrag vermittelt wesentliche, grundlegende Aspekte des Vibrationstrainings. Die wichtigsten Wirkmechanismen werden dargestellt und die Integration des Vibrationstrainings in die Sportther weiter...

Author: Kleinöder H, Mester J
Source: BISp-Jahrbuch, 2003; 253-258
Keywords: Galileo Transmission to Head
Doc-ID: 277,

Clinical Studies

Vastus lateralis oxygenation and blood volume measured by near-infrared spectroscopy during whole body vibration

The purpose of this study was to investigate the effects of whole body vibration (WBV) on oxygenation of vastus lateralis muscle during squatting exercise. Eighteen male subjects [mean age, 27.3 +/- 6.0 (SD) ye weiter...

Author: Yamada E, Kusaka T, Miyamoto K, Tanaka S, Morita S, Tanaka S, Tsuji S, Mori S, Norimatsu H, Itoh S
Source: Clin Physiol Funct Imaging., 2005; 25(4): 203-8, PMID: 15972021
Doc-ID: 124,

Clinical Studies

Effect of a vibration exposure on muscular performance and body balance. Randomized cross-over study

This randomized cross-over study was designed to investigate the effects of a 4-min vibration bout on muscle performance and body balance in young, healthy subjects. Sixteen volunteers (eight men, eight women, weiter...

Author: Torvinen S, Kannu P, Sievänen H, Järvinen TA, Pasanen M, Kontulainen S, Järvinen TL, Järvinen M, Oja P, Vuori I
Source: Clin Physiol Funct Imaging., 2002; 22(2): 145-52, PMID: 12005157
Keywords: balance power
Doc-ID: 161,

Clinical Studies

Effect of Whole Body Vibration Stimulus and Voluntary Contraction on Motoneuron Pool

We investigated the influence of transient whole bogy vibration and voluntary contraction on the motorneuron pool. Electromyographic recordings were obtained from the soleus muscle of 17 healthy subjects using weiter...

Author: NISHIHIRA Y, IWASAKI T, HATTA A, WASAKA T, KANEDA T, KUROIWA K, AKIYAMA S, KIDA T, RYOL K S
Source: Adv Exerc Sports Physiol, 2002; 8/4: 83-86
Keywords: H-Reflex
Doc-ID: 162,
More information: Original Article

Clinical Studies

Vibration therapy improves walk, balance in elderly

Good vibrations In the new study, 42 volunteers in a nursing home were randomized to a vibration group or a nontreatment group for 6 weeks. The treatment group underwent 6 weeks of CWBV (4 oneminute series 3 weiter...

Author: Bruyere O
Source: Rheuma wire, 2003;
Doc-ID: 170,

Clinical Studies

Whole-body vibration exercise leads to alterations in muscle blood volume

Occupationally used high-frequency vibration is supposed to have negative effects on blood flow and muscle strength. Conversely, low-frequency vibration used as a training tool appears to increase muscle streng weiter...

Author: Kerschan-Schindl K, Grampp S, Henk C, Resch H, Preisinger E, Fialka-Moser V, Imhof H
Source: Clin Physiol., 2001; 21(3): 377-82, PMID: 11380538
Doc-ID: 172,

Clinical Studies

Whole-body vibration induced adaptation in knee extensors; consequences of initial strength, vibration frequency, and joint angle

It was hypothesized that both vibration frequency and muscle length modulate the strengthening of muscles that is assumed to result from whole-body vibration (WBV). Length of knee extensor muscles during vibrat weiter...

Author: Savelberg HH, Keizer HA, Meijer K
Source: J Strength Cond Res., 2007; 21(2): 589-93, PMID: 17530984
Doc-ID: 173,

Clinical Studies

Verhalten der Knochenmasse postmenopausaler Frauen unter fortlaufend adaptierendem Krafttraining an konventionellen Kraftmaschinen sowie an oszillierenden Geräten ohne und unter Hormoneinfluss

An einem Kollektiv früh- und spät postmenopausaler Frauen, n = 173, mit einem Durchschnittsalter von 56 Jahren wurde über einen Zeitraum von 12 bis 14 Monaten der Einfluss zweier Trainingsmethoden ohne und i weiter...

Author: Baumeister A
Source: Dissertation, 2005;
Keywords: Galileo Dumbbell, Galileo Hantel, Vibrationshantel, vibrating Bumbbell
Doc-ID: 182,
More information: Original Article

Clinical Studies

Wirkung mechanischer Stimuli mittels oszillierender Interventionen durch GALILEO 2000 auf Muskelkraft und Knochendichte

Author: Rößler O, Marsch S, Abendroth K, Meuser K, Hübscher J
Source: Osteologie Jena, 1999;
Doc-ID: 183,
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Clinical Studies

Influence of puberty on muscle area and cortical bone area of the forearm in boys and girls

The aim of the current study is to analyze the interaction of the muscle and bone system (muscle-bone unit) during puberty in males and females by computed tomography of the nondominant forearm. The data presen weiter...

Author: Schoenau E, Neu CM, Mokov E, Wassmer G, Manz F
Source: J Clin Endocrinol Metab., 2000; 85(3): 1095-8, PMID: 10720045
Keywords: Bone Adaptation
Doc-ID: 192,

Clinical Studies

Balance training and exercise in geriatric patients

Objective measures of gait and balance which meet the criteria of reliability and validity are required as a basis for exercise regimens. We established reference values of clinically relevant locomotor and bal weiter...

Author: Runge M, Rehfeld G, Resnicek E
Source: J Musculoskelet Neuronal Interact., 2000; 1(1): 61-5, PMID: 15758528
Keywords: elderly balance
Doc-ID: 194,

Clinical Studies

Acute physiological effects of exhaustive whole-body vibration exercise in man

Vibration exercise (VE) is a new neuromuscular training method which is applied in athletes as well as in prevention and therapy of osteoporosis. The present study explored the physiological mechanisms of fatig weiter...

Author: Rittweger J, Beller G, Felsenberg D
Source: Clin Physiol., 2000; 20(2): 134-42, PMID: 10735981
Doc-ID: 195,

Clinical Studies

Adaptive responses of human skeletal muscle to vibration exposure

The aim of this study was to investigate the effects of whole-body vibrations (WBV) on the mechanical behaviour of human skeletal muscle. For this purpose, six female volleyball players at national level were r weiter...

Author: Bosco C, Colli R, Introini E, Cardinale M, Tsarpela O, Madella A, Tihanyi J, Viru A
Source: Clin Physiol., 1999; 19(2): 183-7, PMID: 10200901
Doc-ID: 203,

Clinical Studies

The Effect of Whole-Body Vibration on Mechanical Behaviour of Skeletal Muscle and Hormonal Profil

Author: Bosco C, Colli R, Cardinale M, Tsarpela O, Bonifazi M
Source: Musculo-Skeletal Interactions, 1999; 2: 67-76
Doc-ID: 211,

Clinical Studies

Oxygen uptake during whole-body vibration exercise: comparison with squatting as a slow voluntary movement

In this study we investigated metabolic power during whole-body vibration exercise (VbX) compared to mild resistance exercise. Specific oxygen consumption (VO2) and subjectively perceived exertion (rating of pe weiter...

Author: Rittweger J, Schiessl H, Felsenberg D
Source: Eur J Appl Physiol., 2001; 86(2): 169-73, PMID: 11822476
Doc-ID: 231,

Clinical Studies

The Influence of Whole-Body Vibration on the Mechanical Behaviour of Skeletal Muscle

Author: Bosco C, Cardinale M, Colli R, Tihanyi J, von Duvillard SP, Viru A
Source: Clinical Physiology, 1999; 19: 183-187
Doc-ID: 233,

Clinical Studies

Treatment of chronic lower back pain with lumbar extension and whole-body vibration exercise: a randomized controlled trial

STUDY DESIGN: A randomized controlled trial with a 6-month follow-up period was conducted. OBJECTIVE: To compare lumbar extension exercise and whole-body vibration exercise for chronic lower back pain. S weiter...

Author: Rittweger J, Just K, Kautzsch K, Reeg P, Felsenberg D
Source: Spine., 2002; 27(17): 1829-34, PMID: 12221343
Keywords: Back Pain
Doc-ID: 250,

Clinical Studies

The effects of 11 weeks whole body vibration training on jump height, contractile properties and activation of human knee extensors

The purpose of the present study was to investigate whether 11 weeks of whole body vibration (WBV) training applied in a way that is commonly seen in practice, i.e. without additional loads, would improve muscl weiter...

Author: de Ruiter CJ, Van Raak SM, Schilperoort JV, Hollander AP, de Haan A
Source: Eur J Appl Physiol., 2003; 90(5-6): 595-600, PMID: 12923646
Doc-ID: 122,

Clinical Studies

Effect of Acute Exposure to Whole-Body-Vibration on Vertical Jump in Senior Athlete Volleyball Players

Author: Feland JB, Hopkins T, Hunter I, Hunter ATC, Provo UT
Source: Med Sci Sports Exerc, 2006; 38(5):
Doc-ID: 118,
More information: Original Article

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