Fundamental studies for the application area muscle and bone
Here you will find all fundamental studies, listed by date of last update. This category currently includes 393 entries.
Literature (393)
Fundamental Studies (2022)
pQCT Analysis of Cortical Bone in Rats Exposed to High Levels of Cortisol in-utero.
Unperturbed fetal development is essential for future health of an individual. Previous studies have linked diseases of aging to harmful alterations that happen during fetal development. Given the significant l weiter...
Author: Brown SA
Source: FASEB J, 2022; 36 Suppl 1(): , PMID: 35555908
Keywords: Abstract only
GID: 5707; Last update: 17.05.2022
Fundamental Studies (2022)
GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice.
Sex steroid deficiency plays critical roles in the pathophysiology of bone as the result of uncertain bone remodeling, i.e., increased bone resorption with equivocal bone formation. We have previously shown tha weiter...
Author: Chen JR, Lazarenko OP, Blackburn ML
Source: Bone, 2022; 161(): 116422, PMID: 35489706
GID: 5701; Last update: 03.05.2022
Fundamental Studies (2022)
Management of Sarcopenia: A Network Meta-Analysis of Randomized Controlled Trials.
OBJECTIVE: This study aimed to determine the comparative effectiveness of interventions in treatment of sarcopenia. The primary outcome was the measure of treatment effect on muscle mass, and secondary outcome weiter...
Author: Negm AM, Lee J, Hamidian R, Jones CA, Khadaroo RG
Source: J Am Med Dir Assoc, 2022; (): , PMID: 35183490
GID: 5647; Last update: 03.03.2022
Fundamental Studies (2022)
INTRODUCTION: The rice rat (Oryzomys palustris) is a non-conventional laboratory rodent species used to model some human bone disorders. However, no studies have been conducted to characterize the postcranial weiter...
Author: Castillo EJ, Croft S, Jiron JM, Aguirre JI
Source: Anat Rec (Hoboken), 2022; (): , PMID: 35090092
Keywords: Marsh rice rat
GID: 5635; Last update: 01.02.2022
Fundamental Studies (2021)
Whole-body vibration (WBV) is an exercise modality or treatment/prophylaxis method in which subjects (humans, animals, or cells) are exposed to mechanical vibrations through a vibrating platform or device. The weiter...
Author: van Heuvelen MJG, Rittweger J, Judex S, Sanudo B, Seixas A, Fuermaier ABM, Tucha O, Nyakas C, Marin PJ, Taiar R, Stark C, Schoenau E, Sa-Caputo DC, Bernardo-Filho M, van der Zee EA
Source: Biology (Basel), 2021; 10(10): , PMID: 34681065
GID: 5572; Last update: 02.11.2021
Fundamental Studies (2021)
Bilateral asymmetry and developmental plasticity of the humerus in modern humans.
OBJECTIVE: This study investigates bilateral asymmetry in the humerus of modern human populations with differing activity patterns to assess the relative plasticity of different bone regions in response to envi weiter...
Author: Zelazny KG, Sylvester AD, Ruff CB
Source: Am J Phys Anthropol, 2021; 174(3): 418-433, PMID: 33460465
GID: 5319; Last update: 08.03.2021
Fundamental Studies (2021)
Programming Effect of the Parental Obesity on the Skeletal System of Offspring at Weaning Day.
Our study aimed to verify the hypothesis of the existence of a programming effect of parental obesity on the growth, development and mineralization of the skeletal system in female and male rat offspring on the weiter...
Author: Radzki RP, Bienko M, Wolski D, Ostapiuk M, Polak P, Manastyrska M, Kimicka A, Wolska J
Source: Animals (Basel), 2021; 11(2): , PMID: 33562167
GID: 5301; Last update: 16.02.2021
Fundamental Studies (2020)
Transmission of whole body vibration - Comparison of three vibration platforms in healthy subjects.
The potential of whole body vibration (WBV) to maintain or enhance musculoskeletal strength during ageing is of increasing interest, with both low and high magnitude WBV having been shown to maintain or increas weiter...
Author: Spain L, Yang L, Wilkinson JM, McCloskey E
Source: Bone, 2020; 144(): 115802, PMID: 33309990
Keywords: Galileo 900, Powerplate, Juvent
GID: 5288; Last update: 04.02.2021
Fundamental Studies (2021)
Oral Estradiol Impact on Mitigating Unloading-Induced Bone Loss in Ovary-Intact Rats.
BACKGROUND: The impact of the spaceflight environment on endogenous estrogen production in female crewmembers and the resulting impact on other adaptations, like bone loss, is an under-investigated topic. Hence weiter...
Author: Mantri AV, Allaway HCM, Brezicha JE, Hogan HA, Bloomfield SA
Source: Aerosp Med Hum Perform, 2021; 92(2): 65-74, PMID: 33468286
GID: 5281; Last update: 25.01.2021
Fundamental Studies (2020)
The cysteine knot protein sclerostin is an osteocyte-derived secreted inhibitor of the Wnt co-receptors LRP5 and LRP6. LRP5 plays a dominant role in bone homeostasis, but we previously reported that Sost/sclero weiter...
Author: Lim KE, Bullock WA, Horan DJ, Williams BO, Warman ML, Robling AG
Source: Bone, 2020; 143(): 115708, PMID: 33164872
GID: 5241; Last update: 03.12.2020
Fundamental Studies (2020)
Automated resolution independent method for comparing in vivo and dry trabecular bone.
OBJECTIVES: Variation in human trabecular bone morphology can be linked to habitual behavior, but it is difficult to investigate in vivo due to the radiation required at high resolution. Consequently, functiona weiter...
Author: Saers JPP, DeMars LJ, Stephens NB, Jashashvili T, Carlson KJ, Gordon AD, Ryan TM, Stock JT
Source: Am J Phys Anthropol, 2020; 174(4): 822-831, PMID: 33244765
GID: 5240; Last update: 03.12.2020
Fundamental Studies (2021)
The aim of this study was to investigate if the distribution of subchondral volumetric bone mineral density (vBMD) from peripheral quantitative computed tomography (pQCT) is related to estimates of knee joint l weiter...
Author: Thewlis D, Waters A, Solomon LB, Perilli E
Source: Bone, 2021; 143(): 115662, PMID: 32987197
GID: 5206; Last update: 05.10.2020
Fundamental Studies (2020)
Analysis of low-dose estrogen on fracture healing measured by pQCT in postmenopausal women
Background The skeletal disease osteoporosis affects primarily postmenopausal women. It is characterized by increased fracture risk due to defective remodeling of bone tissue and a pathological bone microarchi weiter...
Author: Katharina Blanka Dr. Jäckle, Jan Philipp Kolb, Arndt F Schilling
Source: PREPRINT (Version 1) available at Research Square [+https://doi.org/10.21203/rs.3.rs-29939/v1+], 2020;
Keywords: estrogen, fracture healing, osteoporosis, callus formation
GID: 5144; Last update: 16.06.2020
Fundamental Studies (2020)
Background Whole-body vibration training has recently been proposed as a complementary training modality to improve the bone health of adolescent swimmers. However, there is no longitudinal study regarding the weiter...
Author: Marin-Puyalto J, Gomez-Cabello A, Gonzalez-Aguero A, Matute-Llorente A, Gomez-Bruton A, Jurimae J, Casajus JA, Vicente-Rodriguez G
Source: J Pediatr Endocrinol Metab, 2020; 33(5): 623-630, PMID: 32229668
GID: 5089; Last update: 06.04.2020
Fundamental Studies (2020)
Site-Specific Effects of Swimming on Bone Density in Female Collegiate Swimmers.
While swimming provides numerous cardiovascular and overall health benefits, past research suggests it provides no constructive benefits to bone strength and density at dual energy x-ray absorptiometry (DXA) me weiter...
Author: Miller M, Kojetin S, Scibora L
Source: Int J Exerc Sci, 2020; 13(1): 249-259, PMID: 32148613
GID: 5078; Last update: 16.03.2020
Fundamental Studies (2020)
In osteogenesis imperfecta (OI), vertebrae brittleness causes thorax deformations and leads to cardiopulmonary failure. As sclerostin-neutralizing antibodies increase bone mass and strength in animal models of weiter...
Author: Cardinal M, Dessain A, Roels T, Lafont S, Ominsky MS, Devogelaer JP, Chappard D, Mabilleau G, Ammann P, Nyssen-Behets C, Manicourt DH
Source: Calcif Tissue Int, 2020; 106(5): 106(5):494-508, PMID: 32025752
GID: 5041; Last update: 11.02.2020
Fundamental Studies (2019)
Evolutions of temperature and density during roll compaction of a pharmaceutical excipient.
Roll compaction is a critical unit operation in the pharmaceutical manufacture. During roll compaction, a change in the internal energy of powder due to applying of external work from the rolls can generate hea weiter...
Author: Krok A, Wu CY
Source: Int J Pharm, 2019; 572(): 118822, PMID: 31678375
GID: 4994; Last update: 19.11.2019
Fundamental Studies (2020)
Bone and muscle have shown to interact, but little is known about fat within bone and muscle. Clinical studies have isolated fat within bone and muscle using MRI. In this cross-sectional study, we hypothesized weiter...
Author: Wong AK, Chandrakumar A, Whyte R, Reitsma S, Gillick H, Pokhoy A, Papaioannou A, Adachi JD
Source: J Bone Miner Res, 2020; 35(3): 516-527, PMID: 31675452
GID: 4995; Last update: 19.11.2019
Fundamental Studies (2020)
Novel anabolic drug targets are needed to treat osteoporosis. Having established a large national cohort with unexplained high bone mass (HBM), we aimed to identify a novel monogenic cause of HBM and provide i weiter...
Author: Gregson CL, Bergen D, Leo P, Sessions RB, Wheeler L, Hartley A, Youlten S, Croucher PI, McInerney-Leo AM, Fraser W, Tang JCY, Anderson L, Marshall M, Sergot L, Paternoster L, Davey-Smith G, Brown MA, Hammond C, Kemp JP, Tobias JH, Duncan EL
Source: J Bone Miner Res, 2020; 35(1): 92-105, PMID: 31525280
GID: 4977; Last update: 26.09.2019
Fundamental Studies (2019)
Bisphosphonate alendronate (ALN), phytoestrogen 8-prenylnaringenin (8-PN) and the whole body vibration exert a favorable effect on osteoporotic bone. However, the impact of these treatments and the combination weiter...
Author: Komrakova M, Rechholtz C, Pohlmann N, Lehmann W, Schilling AF, Wigger R, Sehmisch S, Hoffmann DB
Source: Bone Rep, 2019; 11(): 100224, PMID: 31516917
GID: 4962; Last update: 16.09.2019
Fundamental Studies (2019)
Objective: To determine the effect of an antibody to vascular endothelial growth factor (VEGF) on bone blood flow, bone strength, and bone mass in the young adult mouse. Methods: Ten-week-old male BALB/cJ mice weiter...
Author: Lane NE, Nyman JS, Uppuganti S, Chaudhari AJ, Aguirre JI, Shidara K, Liu XP, Yao W, Kimmel DB
Source: Bone Rep, 2019; 10(): 100210, PMID: 31193542
GID: 4925; Last update: 17.06.2019
Fundamental Studies (2019)
Since stress fractures are common among adolescent athletes, it is important to identify bone assessment tools that accurately identify risk. We investigated the discriminative ability of two imaging technologi weiter...
Author: Duckham RL, Bialo SR, Machan J, Kriz P, Gordon CM
Source: Osteoporos Int, 2019; 30(8): 1573–1580, PMID: 31143993
GID: 4911; Last update: 03.06.2019
Fundamental Studies (2019)
pQCT- and Ultrasound-based Muscle and Fat Estimate Errors after Resistance Exercise.
PURPOSE: Resistance exercise increases blood flow, induces osmotic and hydrostatic fluid shifts during and immediately after exercise, and may trigger inflammatory responses for several days in the working musc weiter...
Author: Rowe GS, Blazevich AJ, Haff GG
Source: Med Sci Sports Exerc, 2019; 51(5): 1022-1031, PMID: 30986813
GID: 4894; Last update: 23.04.2019
Fundamental Studies (2019)
The aim of this study was to estimate cortical porosity (Ct.Po) and cortical thickness (Ct.Th) using 500-kHz bi-directional axial transmission (AT). Ct.ThAT and Ct.PoAT were obtained at the tibia in 15 patients weiter...
Author: Schneider J, Ramiandrisoa D, Armbrecht G, Ritter Z, Felsenberg D, Raum K, Minonzio JG
Source: Ultrasound Med Biol, 2019; 45(51234-1242): , PMID: 30777311
GID: 4864; Last update: 26.02.2019
Fundamental Studies (2019)
BACKGROUND: Excess weight exerts the positive effect of mechanical loading on bone during development whereas obesity-related metabolic dysfunction may have a detrimental impact. In adults, the presence of met weiter...
Author: Hetherington-Rauth M, Bea JW, Blew RM, Funk JL, Lee VR, Roe DJ, Sardinha LB, Going SB
Source: Bone, 2019; 120(): 452-458, PMID: 30572143
GID: 4818; Last update: 08.01.2019
Fundamental Studies (2018)
The present study shows that football practice during growth may improve bone geometry in male and female football players. However, only females had better bone strength in comparison with controls. PURPOSE: T weiter...
Author: Lozano-Berges G, Matute-Llorente A, Gomez-Bruton A, Gonzalez-Aguero A, Vicente-Rodriguez G, Casajus JA
Source: Arch Osteoporos, 2018; 13(1): 57, PMID: 29737414
GID: 4685; Last update: 22.05.2018
Fundamental Studies (2018)
Low birth weight programs diseases in adulthood, including adverse bone health. These diseases can have intergenerational and transgenerational origins, whereby transmission to subsequent generations occurs vi weiter...
Author: Anevska K, Wark JD, Wlodek ME, Romano T
Source: J Dev Orig Health Dis, 2018; 314(): 161-170, PMID: 29631641
GID: 4663; Last update: 13.04.2018
Fundamental Studies (2018)
Long-term diabetes mellitus can induce osteopenia and osteoporosis, an increase in the incidence of low-stress fractures, and/or delayed fracture healing. Strontium ranelate (SrR) is a dual-action anti-osteopor weiter...
Author: Alvarez-Lloret P, Fernandez JM, Molinuevo MS, Lino AB, Ferretti JL, Capozza RF, Cortizo AM, McCarthy AD
Source: Biol Trace Elem Res, 2018; 186(2): 457-466, PMID: 29623650
GID: 4661; Last update: 09.04.2018
Fundamental Studies (2018)
Aldehyde dehydrogenase 2 (ALDH2) is the enzyme that degrades and detoxifies the acetaldehyde produced by alcohol metabolism. In our previous study, we found that compared with wild-type mice (WT), climbing exer weiter...
Author: Tajima T, Menuki K, Okuma KF, Tsukamoto M, Fukuda H, Okada Y, Kosugi K, Yamanaka Y, Uchida S, Sakai A
Source: Bone, 2018; (): 254-266, PMID: 29482068
GID: 4632; Last update: 27.02.2018
Fundamental Studies (2017)
Can whole body vibration exercises affect growth hormone concentration? A systematic review.
Whole body vibration (WBV) has been recognized as an effective alternative exercise modality to resistance exercise for its ability in enhancing force and power, generating capacity in skeletal muscle, increasi weiter...
Author: Paineiras-Domingos LL, Sa-Caputo DDC, Moreira-Marconi E, Morel DS, da Fontoura Dionello C, Sousa-Goncalves CR, Frederico EHFF, Marin PJ, Tamini S, Sartorio A, Bernardo-Filho M
Source: Growth Factors, 2017; 35(4-5): 189-200, PMID: 29228887
Keywords: Metaanalysis
GID: 4585; Last update: 14.01.2018
Fundamental Studies (2017)
Abaloparatide, a novel PTH1 receptor agonist, increased bone formation in osteopenic ovariectomized cynomolgus monkeys while increasing cortical and trabecular bone mass. Abaloparatide increased bone strength a weiter...
Author: Doyle N, Varela A, Haile S, Guldberg R, Kostenuik PJ, Ominsky MS, Smith SY, Hattersley G
Source: Osteoporos Int, 2017; (): , PMID: 29260289
GID: 4576; Last update: 08.01.2018
Fundamental Studies (2018)
The study was aimed at determining the osteotropic effects of diets containing snail meat as a sole protein source. In our experiment, we tested three different diets incorporating snail meat originating from H weiter...
Author: Radzki RP, Bienko M, Polak P, Szkucik K, Ziomek M, Ostapiuk M, Bienias J
Source: J Anim Physiol Anim Nutr (Berl), 2018; 102(): 885-891, PMID: 29218776
GID: 4577; Last update: 08.01.2018
Fundamental Studies (2017)
Physical inactivity leads to a deconditioning of the skeletal, neuromuscular and cardiovascular system. It can lead to impaired quality of life, loss of autonomy, falls and fractures. Regular exercise would be weiter...
Author: Kramer A, Gollhofer A, Armbrecht G, Felsenberg D, Gruber M
Source: Sci Rep, 2017; 7(1): 13177, PMID: 29030644
Keywords: leonardo Jumping Table, BedRest
GID: 4555; Last update: 14.11.2017
Fundamental Studies (2018)
Females born growth restricted have poor adult bone health. Stress exposure during pregnancy increases risk of pregnancy complications. We determined whether maternal stress exposure in growth restricted female weiter...
Author: Anevska K, Cheong JN, Wark JD, Wlodek ME, Romano T
Source: Am J Physiol Regul Integr Comp Physiol, 2018; 314(): 161-170, PMID: 28978512
GID: 4544; Last update: 12.10.2017
Fundamental Studies (2020)
Muscle power predicts bone strength in Division II athletes.
The relationship between muscle fitness measures and tibial bone strength in collegiate level athletes was investigated. Eighty-six Division II collegiate athletes (age: (18-29 years), height: 1.71 m (.09): mas weiter...
Author: Yingling VR, Webb S, Inouye C, O J, Sherwood JJ
Source: J Strength Cond Res, 2020; 34(6): 1657-1665, PMID: 28859012
GID: 4498; Last update: 01.09.2017
Fundamental Studies (2017)
Physiological concentrations of thyroid hormones are crucial for skeletal growth and development, physiological bone turnover and bone homeostasis maintenance. Methimazole (1-methyl-2-mercaptoimidazole) is an weiter...
Author: Tatara MR, Golynski M, Radzki RP, Bienko M, Krupski W
Source: Biomed Pharmacother, 2017; 94(): 124-128, PMID: 28759749
GID: 4501; Last update: 01.09.2017
Fundamental Studies (2018)
Mineral features of connective dental hard tissues in hypoplastic amelogenesis imperfecta.
OBJECTIVE: To explore the mineral features of dentin and cementum in hypoplastic AI teeth MATERIALS AND METHODS: Forty four (44) teeth cleaned and free of caries were used: 20 control and 24 affected by hypop weiter...
Author: Kammoun R, Behets C, Mansour L, Ghoul-Mazgar S
Source: Oral Dis, 2018; 24(): 384-392, PMID: 28771955
GID: 4482; Last update: 14.08.2017
Fundamental Studies (2015)
The intention of this study was to systematically analyze the impact of biomechanical parameters in terms of different peak-to-peak displacements and knee angles on trunk and neck muscle activity during whole-b weiter...
Author: Perchthaler D, Hauser S, Heitkamp HC, Hein T, Grau S
Source: J Sports Sci Med, 2015; 14(1): 155-62, PMID: 25729303
Keywords: EMG on lower back during vibration training
Vibration, electromyography, torso, paraspinal
muscles. EMG, Lower Back Muscles, Upper Back Muscles
#GRFS8
GID: 3839; Last update: 08.04.2015
More information: Original Article
Fundamental Studies (2015)
BACKGROUND: Studies in childhood suggest that both body composition and early postnatal growth are associated with bone mineral density (BMD). However, little is known of the relationships between longitudinal weiter...
Author: Moon RJ, Cole ZA, Crozier SR, Curtis EM, Davies JH, Gregson CL, Robinson SM, Dennison EM, Godfrey KM, Inskip HM, Cooper C, Harvey NC
Source: Bone, 2015; 75(): 105-10, PMID: 25703480
GID: 3852; Last update: 08.04.2015
Fundamental Studies (2015)
Low birth weight, due to uteroplacental insufficiency, results in programmed bone deficits in the first generation (F1). These deficits may be passed onto subsequent generations. We characterized the effects of weiter...
Author: Anevska K, Gallo LA, Tran M, Jefferies AJ, Wark JD, Wlodek ME, Romano T
Source: Bone, 2015; 74(): 199-207, PMID: 25659207
GID: 3856; Last update: 08.04.2015
Fundamental Studies (2013)
Musculoskeletal response of dystrophic mice to short term, low intensity, high frequency vibration.
Objectives: We aimed to identify parameters of low-intensity vibration that initiate the greatest osteogenic response in dystrophin-deficient mice and determine vibration safety for diseased muscle in three sep weiter...
Author: Novotny SA, Eckhoff MD, Eby BC, Call JA, Nuckley D, Lowe DA
Source: J Musculoskelet Neuronal Interact, 2013; 13(4): 418-29, PMID: 24292612
GID: 3422; Last update: 10.01.2014
Fundamental Studies (2013)
Objective: Low intensity vibration as a therapeutic and training modality has received increased attention despite the lack of clear mechanistic pathways. Thus, to determine mechanisms underpinning vibration-in weiter...
Author: Novotny SA, Mehta H, Lowe DA, Nuckley DJ
Source: J Musculoskelet Neuronal Interact, 2013; 13(4): 412-7, PMID: 24292611
GID: 3423; Last update: 10.01.2014
Fundamental Studies (2013)
Elderly patients with diabetes and peripheral neuropathy are more likely to experience falls. However, the information available on how such falls can be prevented is scarce. We investigated the effects of whol weiter...
Author: Lee K, Lee S, Song C
Source: Tohoku J Exp Med, 2013; 231(4): 305-14, PMID: 24334483
Keywords: Muscle Power, Balance, HbA1c, Diabetes, Flexibility
#GRFS55
GID: 3411; Last update: 08.01.2014
Fundamental Studies (2013)
PURPOSE: Many potential countermeasures for muscle and bone loss caused by exposure to microgravity require an uncompromised stretch reflex system. This is especially true for whole body vibration (WBV), as the weiter...
Author: Kramer A, Gollhofer A, Ritzmann R.
Source: J Electromyogr Kinesiol., 2013; 23(4): 872-8, PMID: 23541330
Keywords: Parabolic flights
Bed rest
Countermeasure
Bone loss
Muscle loss
Space, Spinal Excitability
#GRFS104, #GRFS105
GID: 3194; Last update: 06.06.2013
Fundamental Studies (2013)
Side-to-Side Differences in the Lower Leg Muscle-Bone Unit in Male Soccer Players.
Purpose: To characterize side-to-side differences in the lower leg muscle-bone unit between the non-dominant leg (NL) and the dominant leg (DL) using maximum voluntary forefoot ground reaction force (Fm1LH) dur weiter...
Author: Anliker E, Sonderegger A, Toigo M.
Source: Med Sci Sports Exerc., 2013; 45(8): 1545-1552, PMID: 23470305
Keywords: MAXIMUM VOLUNTARY
MUSCLE FORCE, MULTIPLE ONE-LEGGED HOPPING (M1LH), BONE STRENGTH, PERIPHERAL QUANTITATIVE
COMPUTED TOMOGRAPHY (PQCT), TIBIA
GID: 3215; Last update: 06.06.2013
Fundamental Studies (2013)
Whole-body vibration improves functional recovery in spinal cord injured rats.
Whole-body vibration (WBV) is a relatively novel form of exercise used to improve neuromuscular performance in healthy individuals. Its usefulness as a therapy for patients with neurological disorders, in parti weiter...
Author: Wirth F, Schempf G, Stein G, Wellmann K, Manthou M, Scholl C, Sidorenko M, Semler O, Eisel L, Harrach R, Angelova S, Jaminet P, Ankerne J, Ashrafi M, Ozsoy O, Ozsoy U, Schubert H, Abdulla D, Dunlop SA, Angelov DN, Irintchev A, Schonau E
Source: J Neurotrauma, 2013; 30(6): 453-68, PMID: 23157611
GID: 3068; Last update: 27.11.2012
Fundamental Studies (2012)
Objectives: This study evaluated the influence of diet-induced obesity on bone tissue quantity and quality in the proximal tibiae of growing mice and also examined the relationships between the serum total chol weiter...
Author: Fujita Y, Watanabe K, Maki K
Source: J Musculoskelet Neuronal Interact, 2012; 12(2): 84-94, PMID: 22647282
GID: 2972; Last update: 04.06.2012
More information: Original Article
Fundamental Studies (2012)
This study recorded the response to training of the diaphysis of the proximal phalangeal bone and the third metacarpal bone (Mc3) and the Mc3 proximal metaphysis. Nineteen 2- and 3-year old horses in training w weiter...
Author: Firth EC, Rogers CW, van Weeren PR, Barneveld A, McIlwraith CW, Kawcak CE, Goodship AE, Smith RK
Source: Vet J, 2012; 192(1): 34-40, PMID: 21855374
GID: 2922; Last update: 19.03.2012
Fundamental Studies (2010)
Analyses of muscular mass and function: the impact on bone mineral density and peak muscle mass
Bone density and bone mass are commonly regarded as the essential parameters to describe fracture risk in osteology. Because fractures primarily depend on bone strength and secondarily on bone mass and density, weiter...
Author: Fricke O, Beccard R, Semler O, Schoenau E
Source: Pediatr Nephrol., 2010; 25(12): 2393-400, PMID: 20458595
GID: 2571; Last update: 22.02.2011
Fundamental Studies (2010)
Objectives: To assess the effect of conditioning exercise on bone parameters at multiple sites in the radius and tibia of young Thoroughbred horses. Methods: The left and right radius and tibia were obtained fr weiter...
Author: Nicholson CL, Firth EC
Source: J Musculoskelet Neuronal Interact., 2010; 10(3): 199-206, PMID: 20811144
GID: 2393; Last update: 03.09.2010
More information: Original Article
Fundamental Studies (2010)
Biological underpinnings of Frost"s mechanostat thresholds: The important role of osteocytes
Harold Frost first proposed the existence of several mechanical thresholds in bone, two of which determine whether bone is added to, or lost from, the skeleton. Recent evidence from bone biology helps elucidate weiter...
Author: Hughes JM, Petit MA
Source: J Musculoskelet Neuronal Interact., 2010; 10(2): 128-35, PMID: 20516629
GID: 2293; Last update: 07.06.2010
More information: Original Article
Fundamental Studies (2007)
Author: Cointry GR, Capozza RF, Meta M, Mondelo N, Piccini E, Ferretti JL
Source: ASBMR, 2007;
GID: 2225; Last update: 09.04.2010
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Fundamental Studies (2007)
Author: Cointry G, Daniele SM, Capozza R, Martinez S, Ulla MR, Tarres MC, Montenegro S, Morisoli L, Ferretti JL
Source: ASBMR, 2007;
GID: 2223; Last update: 09.04.2010
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Fundamental Studies (2009)
Author: Chippe BA, Isla L. De Simone E, Roldan E, Cointry Gm Ferretti JL, Capozza R
Source: ASBMR, 2009;
GID: 2230; Last update: 09.04.2010
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Fundamental Studies (2010)
Biomechanical Evaluation of Peri- and Interprosthetic Fractures of the Femur
BACKGROUND:: Because of an increasing life expectancy of patients and the rising number of joint replacements, peri- and interprosthetic femoral fractures are a common occurrence in most trauma centers. This st weiter...
Author: Lehmann W, Rupprecht M, Hellmers N, Sellenschloh K, Briem D, Püschel K, Amling M, Morlock M, Rueger JM
Source: J Trauma., 2010; PMID: 20093986
GID: 2200; Last update: 23.03.2010
Fundamental Studies (1975)
Walking and running on the level involves external mechanical work, even when speed averaged over a complete stride remains constant. This work must be performed by the muscles to accelerate and/or raise the ce weiter...
Author: Cavagna GA
Source: J Appl Physiol., 1975; 39(1): 174-9, PMID: 1150585
GID: 2037; Last update: 16.11.2009
Fundamental Studies (2007)
Effects of dietary equol administration on ovariectomy induced bone loss in Sprague-Dawley rats
Oestrogen deficiency leads to a considerable bone loss, thus, osteopenia and osteoporosis are serious complications after menopause. OBJECTIVES: To evaluate the effects of a daidzein metabolite equol on bone ma weiter...
Author: Rachon D, Seidlová-Wuttke D, Vortherms T, Wuttke W.
Source: Maturitas., 2007; 58(3): 308-15, PMID: 17961939
GID: 2033; Last update: 09.11.2009
Fundamental Studies (2008)
The development of bone in immature rats and in aged rats has not been thoroughly studied. Therefore, we investigated the development of bones in young, middle-aged, and aged female rats. Because most rat chows weiter...
Author: Seidlová-Wuttke D, Jarry H, Jäger Y, Wuttke W
Source: J Bone Miner Metab., 2008; 26(4): 321-7, PMID: 18600397
GID: 2032; Last update: 09.11.2009
Fundamental Studies (2008)
Extracts of the black cohosh (Actaea/Cimicifuga racemosa (CR)) have long been used to treat estrogen deficiency symptoms in women after menopause. Recent data from randomized controlled studies have shown that weiter...
Author: Rachon D, Vortherms T, Seidlová-Wuttke D, Wuttke W.
Source: Maturitas., 2008; 60(3-4): 209-15, PMID: 18691839
GID: 2034; Last update: 09.11.2009
Fundamental Studies (2009)
Physical exercise improves properties of bone and its collagen network in growing and maturing mice
This study characterized bone structure, composition, and mechanical properties in growing male mice. The development of the collagen network during maturation was monitored, and the effect of voluntary physica weiter...
Author: Isaksson H, Tolvanen V, Finnilä MA, Iivarinen J, Tuukkanen J, Seppänen K, Arokoski JP, Brama PA, Jurvelin JS, Helminen HJ
Source: Calcif Tissue Int., 2009; 85(3): 247-56, PMID: 19641838
GID: 1917; Last update: 07.09.2009
Fundamental Studies (2009)
Low birth weight increases the risk of developing adult onset cardiovascular and metabolic diseases. Recently being born small has also been identified as a risk factor for adverse bone growth, development and weiter...
Author: Romano T, Wark JD, Owens JA, Wlodek ME
Source: Bone., 2009; 45(1): 132-41, PMID: 19332163
GID: 1840; Last update: 21.07.2009
Fundamental Studies (2008)
Beneficial effects of soy protein consumption on bone quality have been reported. The effects of other dietary protein sources such as whey protein hydrolysate (WPH) and rice protein isolate (RPI) on bone growt weiter...
Author: Chen JR, Singhal R, Lazarenko OP, Liu X, Hogue WR, Badger TM, Ronis MJ
Source: Exp Biol Med (Maywood)., 2008; 233(11): 1348-58, PMID: 18703746
GID: 1838; Last update: 21.07.2009
Fundamental Studies (2009)
Binge alcohol-related bone damage is prevented by concurrent administration of bisphosphonates, suggesting an activation of bone resorption with patterned alcohol exposure. Although chronic alcohol abuse is kno weiter...
Author: Callaci JJ, Himes R, Lauing K, Wezeman FH, Brownson K
Source: Calcif Tissue Int., 2009; 84(6): 474-84, PMID: 19330277
GID: 1839; Last update: 21.07.2009
Fundamental Studies (2009)
Several methods have been used to increase bone mass in distraction osteogenesis. Since bone resorption as well as regeneration is stimulated in the distracted segment, bisphosphonate can be a beneficial agent weiter...
Author: Abbaspour A, Takahashi M, Sairyo K, Takata S, Yukata K, Inui A, Yasui N
Source: Bone., 2009; 44(5): 917-23, PMID: 19442623
GID: 1822; Last update: 03.07.2009
Fundamental Studies (2008)
Automatic segmentation of cortical and trabecular components of bone specimens acquired by pQCT
Peripheral Quantitative Computerized Tomography (pQCT) allows the acquisition of bone specimens with a spatial resolution adequate to visualize the 3D structure of the bone cortex and the trabecular network. At weiter...
Author: Rizzo G, Tresoldi D, Scalco E, Mendez M, Bianchi AM, Moro GL, Rubinacci A
Source: Conf Proc IEEE Eng Med Biol Soc., 2008; 2008: 486-9, PMID: 19162699
GID: 1738; Last update: 17.03.2009
Fundamental Studies (2009)
This study evaluated whether transgenic expression of PTP-oc (osteoclastic transmembrane protein-tyrosine phosphatase) in cells of the osteoclast lineage would affect bone resorption and bone density in young a weiter...
Author: Sheng MH, Amoui M, Stiffel V, Srivastava AK, Wergedal JE, Lau KH
Source: J Biol Chem., 2009; 284(17): 11531-45, PMID: 19244239
GID: 1736; Last update: 17.03.2009
Fundamental Studies (2009)
A genome-wide linkage analysis to identify quantitative trait loci (QTLs) for bone phenotypes was performed in an F(2) intercross of inbred spontaneously type 2 diabetic GK and normoglycemic F344 rats (108 mal weiter...
Author: Lagerholm S, Li LS, Jiao H, Park HB, Ohlsson C, Akesson K, Luthman H
Source: J Bone Miner Res, 2009; 24(6): 1066-74, PMID: 19113924
GID: 1723; Last update: 17.02.2009
Fundamental Studies (2009)
Colony-stimulating factor-1 (CSF1) is one of two cytokines required for normal osteoclastogenesis. There are two major isoforms of CSF1, the cell-surface or membrane-bound isoform (mCSF1) and soluble CSF1 (sCSF weiter...
Author: Yao GQ, Wu JJ, Ovadia S, Troiano N, Sun BH, Insogna K
Source: Am J Physiol Endocrinol Metab., 2009; 296(4): E714-20, PMID: 19141689
GID: 1721; Last update: 17.02.2009
Fundamental Studies (2009)
Short-term exposure to dioxin impairs bone tissue in male rats
Chronic and sub-chronic studies in rats have previously shown that dioxin-like compounds impair the bone tissue homeostasis. In the present study, tibiae and serum were analyzed to study possible effects of sho weiter...
Author: Lind PM, Wejheden C, Lundberg R, Alvarez-Lloret P, Hermsen SA, Rodriguez-Navarro AB, Larsson S, Rannug A
Source: Chemosphere., 2009; 75(5): 680-4, PMID: 19152955
GID: 1719; Last update: 17.02.2009
Fundamental Studies (2009)
Exposure to pastures fertilised with sewage sludge disrupts bone tissue homeostasis in sheep
The femurs of male and female sheep (Ovis aries), aged 18 months, bred on pastures fertilized twice annually with sewage sludge (2.25 tonnes dry matter/ha; Treated; T)) or on pastures treated with inorganic fer weiter...
Author: Lind PM, Gustafsson M, Hermsen SA, Larsson S, Kyle CE, Orberg J, Rhind SM
Source: Sci Total Environ., 2009; 407(7): 2200-8, PMID: 19162300
GID: 1717; Last update: 17.02.2009
Fundamental Studies (2009)
Both ovariectomized animals and animals fed with Ca-depleted diets are commonly used in vivo models for the investigation of osteoporosis-related bone loss. The present study aimed to study the genomic response weiter...
Author: Zhang Y, Dong XL, Leung PC, Wong MS
Source: Bone., 2009; 44(1): 46-52, PMID: 18848653
GID: 1702; Last update: 13.02.2009
Fundamental Studies (2008)
ABSTRACT: BACKGROUND: Hip fracture is associated with pronounced morbidity and excess mortality in elderly women with postmenopausal osteoporosis. Many drugs have been developed to treat osteoporosis and to red weiter...
Author: Nakamura Y, Naito M, Hayashi K, Fotovati A, Abu-Ali S
Source: J Orthop Surg Res., 2008; 3: 51, PMID: 19091077
GID: 1701; Last update: 02.02.2009
Fundamental Studies (2005)
OBJECTIVE: This study was designed to evaluate the postimpact response of the articular cartilage in the rabbit knee after a single traumatic episode. DESIGN: A novel servo-controlled Rabbit Impact Test System weiter...
Author: Milentijevic D, Rubel IF, Liew AS, Helfet DL, Torzilli PA
Source: J Orthop Trauma., 2005; 19(7): 466-73, PMID: 16056079
GID: 1700; Last update: 21.01.2009
Fundamental Studies (2008)
Bone tissue is one of the target tissues for dioxins and dioxin-like compounds. Therefore, the aim of this study was to investigate effects of in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-d weiter...
Author: Hermsen SA, Larsson S, Arima A, Muneoka A, Ihara T, Sumida H, Fukusato T, Kubota S, Yasuda M, Lind PM
Source: Toxicology., 2008; 253(1-3): 147-52, PMID: 18835322
GID: 1693; Last update: 21.01.2009
Fundamental Studies (2009)
Osteoporosis and muscle frailty are important health problems in elderly men and may be partly related to biological androgen activity. This androgen action can be mediated directly through stimulation of the a weiter...
Author: Callewaert F, Venken K, Ophoff J, De Gendt K, Torcasio A, van Lenthe GH, Van Oosterwyck H, Boonen S, Bouillon R, Verhoeven G, Vanderschueren D
Source: FASEB J., 2009; 23(1): 232-40, PMID: 18809737
GID: 1692; Last update: 21.01.2009
Fundamental Studies (2008)
Hepatocyte growth factor (HGF) was initially identified in cultured hepatocytes and subsequently reported to induce angiogenic, morphogenic, and antiapoptotic activity in various tissues. These properties sugge weiter...
Author: Matsubara H, Tsuchiya H, Watanabe K, Takeuchi A, Tomita K
Source: Clin Orthop Relat Res., 2008; 466(12): 2962-72, PMID: 18813894
GID: 1668; Last update: 12.12.2008
Fundamental Studies (2008)
Changes in subchondral bone mineral density and collagen matrix organization in growing horses
OBJECTIVE: The effects of growth and maturation on the mineral deposition and the collagen framework of equine subchondral bone (SCB) were studied. MATERIALS AND METHODS: Osteochondral specimens (diameter 6 mm) weiter...
Author: Holopainen JT, Brama PA, Halmesmäki E, Harjula T, Tuukkanen J, van Weeren PR, Helminen HJ, Hyttinen MM
Source: Bone., 2008; 43(6): 1108-14, PMID: 18757048
GID: 1665; Last update: 12.12.2008
Fundamental Studies (2008)
The menopausal transition is associated with decreased ovarian function and concomitant decline in estrogen production, which may result in physiological effects such as hot flashes, reduced bone mass, and alte weiter...
Author: Kharode Y, Bodine PV, Miller CP, Lyttle CR, Komm BS
Source: Endocrinology., 2008; 149(12): 6084-91, PMID: 18703623
GID: 1652; Last update: 02.12.2008
Fundamental Studies (2008)
Fracture healing in mice deficient in plasminogen activator inhibitor-1
To evaluate the role of plasminogen activator inhibitor (PAI)-1, a key negative regulator of the plasmin system of extracellular matrix proteases in developmental bone growth and fracture repair, the bone pheno weiter...
Author: Rundle CH, Wang X, Wergedal JE, Mohan S, Lau KH
Source: Calcif Tissue Int., 2008; 83(4): 276-84, PMID: 18820962
GID: 1646; Last update: 24.11.2008
Fundamental Studies (2000)
Sometimes naturally occurring disorders combined with other evidence can provide a "virtual laboratory" exercise that answers old questions and reveals new problems and questions that need appropriately "target weiter...
Author: Frost HM.
Source: J Musculoskelet Neuronal Interact., 2000; Dec;1(2): 113-9., PMID: 15758503
GID: 1643; Last update: 20.11.2008
More information: Original Article
Fundamental Studies (2004)
In vivo human tendon mechanical properties: effect of resistance training in old age
Recent advances in ultrasound scanning have made it possible to obtain the mechanical properties of human tendons in vivo. Application of the in vivo method in elderly individuals showed that their patellar ten weiter...
Author: Maganaris CN, Narici MV, Reeves ND
Source: J Musculoskelet Neuronal Interact., 2004; 4(2): 204-8, PMID: 15615128
GID: 1633; Last update: 19.11.2008
More information: Original Article
Fundamental Studies (2006)
Adaptation of the tendon to mechanical usage
Tendons primarily function as contractile force transmitters, but their mechanical properties may change dependent upon their level of mechanical usage. Using an ultrasound-based technique we have assessed tend weiter...
Author: Reeves ND
Source: J Musculoskelet Neuronal Interact., 2006; 6(2): 174-80, PMID: 16849829
GID: 1632; Last update: 19.11.2008
More information: Original Article
Fundamental Studies (2008)
Health effects associated with the Great Lakes environment were assessed in adult herring gulls (Larus argentatus) in the early 1990s, including the size and quality of their bones. Femurs were excised from 140 weiter...
Author: Fox GA, Lundberg R, Wejheden C, Lind L, Larsson S, Orberg J, Lind PM
Source: J Toxicol Environ Health A., 2008; 71(21): 1448-56, PMID: 18800294
GID: 1584; Last update: 17.11.2008
Fundamental Studies (2008)
Increased cortical remodeling after osteotomy causes posttraumatic osteopenia
Following a fracture, substantial bone mineral loss can occur at the affected limb. The aim of this study was to analyze the changes in cortical bone around the site of a fracture. We analyzed bone mineral dens weiter...
Author: Augat P, Claes L
Source: Bone., 2008; 43(3): 539-43, PMID: 18586599
GID: 1579; Last update: 11.11.2008
Fundamental Studies (2008)
The functions of estrogen receptors (ER) alpha and beta (ER-alpha and beta) in bone and fat tissue are not precisely described. Therefore we studied the effects of a specific ERalpha and ERbeta agonist in bone weiter...
Author: Seidlová-Wuttke D, Prelle K, Fritzemeier KH, Wuttke W
Source: Bone., 2008; 43(5): 849-55, PMID: 18708178
GID: 1569; Last update: 11.11.2008
Fundamental Studies (2008)
INTRODUCTION: It has been widely assumed that osteoclasts play a pivotal role during the entire process of fracture healing. Bisphosphonates (BPs) are anti-catabolic agents commonly used to treat metabolic bone weiter...
Author: McDonald MM, Dulai S, Godfrey C, Amanat N, Sztynda T, Little DG
Source: Bone., 2008; 43(4): 653-62, PMID: 18582604
GID: 1568; Last update: 11.11.2008
Fundamental Studies (2008)
This study sought to determine the role of the pro-apoptotic gene, Bax, in fracture healing by comparing femoral fracture healing in Bax knockout (KO) and wild-type C57BL/6J (background strain) mice. Bax KO fra weiter...
Author: Rundle CH, Wang X, Sheng MH, Wergedal JE, Lau KH, Mohan S
Source: Bone., 2008; 43(5): 880-8, PMID: 18708175
GID: 1567; Last update: 11.11.2008
Fundamental Studies (2008)
Hyperlipidemia impairs osteoanabolic effects of PTH
Epidemiological and in vitro studies have suggested that hyperlipidemia/oxidized phospholipids adversely affect bone. We recently found that oxidized phospholipids attenuate PTH-induced cAMP and immediate-early weiter...
Author: Huang MS, Lu J, Ivanov Y, Sage AP, Tseng W, Demer LL, Tintut Y
Source: J Bone Miner Res., 2008; 23(10): 1672-9, PMID: 18505371
GID: 1555; Last update: 06.11.2008
Fundamental Studies (2008)
It has been reported that alfacalcidol had an anticatabolic and anabolic effect on bone in ovariectomized and aged male rat models, but this has not been tested on intact female rats. The current study was to d weiter...
Author: Liu XQ, Chen HY, Tian XY, Setterberg RB, Li M, Jee WS
Source: J Bone Miner Metab., 2008; 26(5): 425-35, PMID: 18758900
GID: 1552; Last update: 06.11.2008
Fundamental Studies (2008)
Beneficial effects of conjugated linoleic acid and exercise on bone of middle-aged female mice
Conjugated linoleic acids (CLA) are a group of polyunsaturated fatty acids that has recently been shown to have several beneficial effects on different diseases, including prevention of bone loss. The important weiter...
Author: Banu J, Bhattacharya A, Rahman M, Fernandes G
Source: J Bone Miner Metab., 2008; 26(5): 436-45, PMID: 18758901
GID: 1551; Last update: 06.11.2008
Fundamental Studies (2008)
Linkage screen for BMD phenotypes in male and female COP and DA rat strains
Because particular inbred strains of experimental animals are informative for only a subset of the genes underlying variability in BMD, we undertook a genome screen to identify quantitative trait loci (QTLs) in weiter...
Author: Koller DL, Liu L, Alam I, Sun Q, Econs MJ, Foroud T, Turner CH
Source: J Bone Miner Res., 2008; 23(9): 1382-8, PMID: 18707222
GID: 1549; Last update: 06.11.2008
Fundamental Studies (2008)
The objective of this study was to compare the effects of soft tissue coverage by either muscle or fasciocutaneous tissue on the healing of open tibial fractures in a murine model. An open tibial fracture, stri weiter...
Author: Harry LE, Sandison A, Paleolog EM, Hansen U, Pearse MF, Nanchahal J
Source: J Orthop Res., 2008; 26(9): 1238-44, PMID: 18404722
GID: 1546; Last update: 06.11.2008
Fundamental Studies (2008)
Low-density lipoprotein receptor-related protein 5 (LRP5) regulates bone acquisition by controlling bone formation. Because roles of LRP6, another co-receptor for Wnts, in postnatal bone metabolism have not bee weiter...
Author: Kubota T, Michigami T, Sakaguchi N, Kokubu C, Suzuki A, Namba N, Sakai N, Nakajima S, Imai K, Ozono K
Source: J Bone Miner Res., 2008; 23(10): 1661-71, PMID: 18505367
GID: 1545; Last update: 06.11.2008
Fundamental Studies (2008)
INTRODUCTION: Body weight is positively correlated with bone mass and density, and both muscle mass and body fat are thought to play a role in regulating bone metabolism. We examined bone metabolism in calorica weiter...
Author: Hamrick MW, Ding KH, Ponnala S, Ferrari SL, Isales CM
Source: J Bone Miner Res., 2008; 23(6): 870-8, PMID: 18435579
GID: 1544; Last update: 06.11.2008
Fundamental Studies (2008)
Bone formation in interleukin-4 and interleukin-13 depleted mice
BACKGROUND AND PURPOSE: Cytokines play an important role in the complex process of bone formation. We have previously found an altered skeletal phenotype with reduction of cortical bone mass in mice depleted of weiter...
Author: Silfverswärd CJ, Sisask G, Larsson S, Ohlsson C, Frost A, Ljunggren O, Nilsson O
Source: Acta Orthop., 2008; 79(3): 410-20, PMID: 18622847
GID: 1542; Last update: 06.11.2008
Fundamental Studies (2008)
Tamoxifen impairs both longitudinal and cortical bone growth in young male rats
Tamoxifen (Tam) has been used experimentally to treat boys with gynecomastia and girls with McCune-Albright syndrome. This drug was recently shown to inhibit the growth of cultured fetal rat metatarsal bones an weiter...
Author: Karimian E, Chagin AS, Gjerde J, Heino T, Lien EA, Ohlsson C, Sävendahl L
Source: J Bone Miner Res., 2008; 23(8): 1267-77, PMID: 18348701
GID: 1540; Last update: 06.11.2008
Fundamental Studies (2008)
To understand the function of human hydroxysteroid (17beta) dehydrogenase 2 (HSD17B2) in the peripheral tissues in vivo, we studied the bone development in transgenic male mice ubiquitously expressing human HSD weiter...
Author: Shen Z, Peng Z, Sun Y, Väänänen HK, Poutanen M
Source: J Bone Miner Res., 2008; 23(8): 1217-26, PMID: 18348690
GID: 1539; Last update: 06.11.2008
Fundamental Studies (2008)
OBJECTIVE: Natural medicines derived from plants have aroused increasing interest in the prevention and treatment of osteoporosis. This is due to their unique characteristics as these are more suitable for long weiter...
Author: Cao DP, Zheng YN, Qin LP, Han T, Zhang H, Rahman K, Zhang QY
Source: Maturitas., 2008; 59(4): 373-80, PMID: 18468819
GID: 1538; Last update: 06.11.2008
Fundamental Studies (2008)
The aim of this study was to evaluate the effects of combining a porous poly(L-lactide-co-epsilon-caprolactone)/beta-tricalcium phosphate membrane and gelatin sponge incorporating basic fibroblastic growth fact weiter...
Author: Kinoshita Y, Matsuo M, Todoki K, Ozono S, Fukuoka S, Tsuzuki H, Nakamura M, Tomihata K, Shimamoto T, Ikada Y
Source: Int J Oral Maxillofac Surg., 2008; 37(3): 275-81, PMID: 18262760
GID: 1536; Last update: 06.11.2008
Fundamental Studies (2001)
Ground reaction force and spatiotemporal measurements of the gait of the mouse
Measurement of ground reaction forces with force plates permits quantification of the subtle changes in movement associated with a variety of pathophysiological states. The apparatus used here permits simultane weiter...
Author: Clarke KA, Smart L, Still J
Source: Behav Res Methods Instrum Comput., 2001; 33(3): 422-6, PMID: 11591074
GID: 1520; Last update: 09.09.2008
Fundamental Studies (2006)
Force plate for measuring the ground reaction forces in small animal locomotion
The importance of kinetic force plate studies of locomotion in small animals has grown recently with the increasing use of rodent models for studies of musculoskeletal diseases. However, the force plates for us weiter...
Author: Zumwalt AC, Hamrick M, Schmitt D
Source: J Biomech., 2006; 39(15): 2877-81, PMID: 16356506
GID: 1519; Last update: 09.09.2008
Fundamental Studies (2007)
Risedronate did not block the maximal anabolic effect of PTH in aged rats
The study was designed to investigate if pre-treating rats with a therapeutic equivalent dose of risedronate blunted the anabolic effects of PTH, and whether a withdrawal period prior to PTH treatment would alt weiter...
Author: Yao W, Su M, Zhang Q, Tian X, Setterberg RB, Blanton C, Lundy MW, Phipps R, Jee WS
Source: Bone., 2007; 41(5): 813-9, PMID: 17716965
GID: 1501; Last update: 09.09.2008
Fundamental Studies (2008)
Current bisphosphonate therapies effectively prevent bone loss in postmenopausal women. We studied the effect of a single intravenous dose of ZOL in ovariectomized rats. Protection from bone loss was dose depen weiter...
Author: Gasser JA, Ingold P, Venturiere A, Shen V, Green JR
Source: J Bone Miner Res., 2008; 23(4): 544-51, PMID: 18072878
GID: 1500; Last update: 09.09.2008
Fundamental Studies (2008)
Effect of osteoporosis on bone mineral density and fracture repair in a rat femoral fracture model
Osteoporosis (OP) is one of the most prevalent bone diseases worldwide with bone fracture the major clinical consequence. The effect of OP on fracture repair is disputed and although it might be expected for fr weiter...
Author: McCann RM, Colleary G, Geddis C, Clarke SA, Jordan GR, Dickson GR, Marsh D
Source: J Orthop Res., 2008; 26(3): 384-93, PMID: 17960650
GID: 1499; Last update: 09.09.2008
Fundamental Studies (2008)
INTRODUCTION: Hypogonadism is considered to be one of the major risk factors for osteoporosis in men. Here, we sequentially studied the effects of androgen deficiency on cortical bone in aged orchiectomy (ORX) weiter...
Author: Reim NS, Breig B, Stahr K, Eberle J, Hoeflich A, Wolf E, Erben RG
Source: J Bone Miner Res., 2008; 23(5): 694-704, PMID: 18433303
GID: 1498; Last update: 09.09.2008
Fundamental Studies (2008)
We have previously demonstrated bone loss of the mandible and femur in experimental osteoporotic rats and its prevention by medication, using peripheral quantitative computed tomography (pQCT). In the present s weiter...
Author: Jiang GZ, Matsumoto H, Hori M, Gunji A, Hakozaki K, Akimoto Y, Fujii A
Source: J Bone Miner Metab., 2008; 26(2): 130-7, PMID: 18301968
GID: 1497; Last update: 09.09.2008
Fundamental Studies (2008)
Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats
EtOH consumption significantly impaired anabolic rebuilding of bone after lactation. Lower BMD and BMC in EtOH-fed rats were associated with decreased bone formation in the proximal tibia, increased proportion weiter...
Author: Shankar K, Hidestrand M, Liu X, Chen JR, Haley R, Perrien DS, Skinner RA, Lumpkin CK Jr, Badger TM, Ronis MJ
Source: J Bone Miner Res., 2008; 23(3): 338-49, PMID: 17967133
GID: 1496; Last update: 09.09.2008
Fundamental Studies (2008)
Reduced bone toughness, the energy absorption capacity of the tissue, has been consistently documented in vertebrae of animals treated with a wide range of bisphosphonate doses. Data regarding toughness changes weiter...
Author: Allen MR, Reinwald S, Burr DB
Source: Calcif Tissue Int., 2008; 82(5): 354-60, PMID: 18463913
GID: 1495; Last update: 09.09.2008
Fundamental Studies (2008)
Pathogenesis of age-related osteoporosis: impaired mechano-responsiveness of bone is not the culprit
BACKGROUND: According to prevailing understanding, skeletal mechano-responsiveness declines with age and this apparent failure of the mechano-sensory feedback system has been attributed to the gradual bone loss weiter...
Author: Leppänen OV, Sievänen H, Jokihaara J, Pajamäki I, Kannus P, Järvinen TL
Source: PLoS ONE., 2008; 3(7): e2540, PMID: 18648530
GID: 1494; Last update: 09.09.2008
Fundamental Studies (2007)
CASE HISTORY: A 4-year-old female Labrador Retriever was diagnosed with an osteolytic lesion of the right distal radius. CLINICAL FINDINGS: Radiographs indicated a well-circumscribed radiolucent area 18 x 15 x weiter...
Author: Worth AJ, Thompson KG, Owen MC, Mucalo MR, Firth EC
Source: N Z Vet J., 2007; 55(3): 143-8, PMID: 17534418
GID: 1401; Last update: 22.07.2008
Fundamental Studies (2008)
CART deficiency increases body weight but does not alter bone strength
The regulation of bone metabolism mediated by leptin is a complex process that is not clearly understood. Recent studies suggest that CART (cocaine-amphetamine related transcript) is a significant neuronal co-f weiter...
Author: Bartell SM, Isales CM, Baile CA, Kuhar MJ, Hamrick MW
Source: J Musculoskelet Neuronal Interact., 2008; 8(2): 146-53, PMID: 18622083
GID: 1400; Last update: 22.07.2008
More information: Original Article
Fundamental Studies (2008)
BACKGROUND: Osteoporosis is a potential risk factor affecting implant stability following total joint arthroplasty. Bisphosphonates are potent inhibitors of osteoblastic bone resorption, and vitamin D is an i weiter...
Author: Nakamura Y, Hayashi K, Abu-Ali S, Naito M, Fotovati A
Source: J Bone Joint Surg Am., 2008; 90(4): 824-32, PMID: 18381321
GID: 1399; Last update: 22.07.2008
Fundamental Studies (2007)
Statins potently inhibit 3-hydroxy-3-methylglutaryl-coenzyme A reductase, blocking downstream biosynthesis of isoprenoid lipids and causing inhibition of protein prenylation. Prenylated signaling molecules are weiter...
Author: Hughes A, Rogers MJ, Idris AI, Crockett JC
Source: Calcif Tissue Int., 2007; 81(5): 403-13, PMID: 17982704
GID: 1398; Last update: 22.07.2008
Fundamental Studies (2008)
The benefits of impact exercise and dietary calcium on bone development are controversial. We used inbred rats under highly controlled conditions to test the independent and combined effects of impact exercise weiter...
Author: Welch JM, Turner CH, Devareddy L, Arjmandi BH, Weaver CM
Source: Bone., 2008; 42(4): 660-8, PMID: 18291744
GID: 1397; Last update: 22.07.2008
Fundamental Studies (2008)
Osteoporosis is characterized by impaired bone quality leading to increased susceptibility to fracture, particularly of the thoracic spine. However, the lumbar spine is studied most commonly. We investigated th weiter...
Author: Fox J, Newman MK, Turner CH, Guldberg RE, Varela A, Smith SY
Source: Calcif Tissue Int., 2008; 82(3): 212-20, PMID: 18297227
GID: 1396; Last update: 22.07.2008
Fundamental Studies (2008)
Epistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats
To further delineate the factors underlying the complex genetic architecture of BMD in the rat model, a genome screen for epistatic interactions was conducted. Several significant interactions were identified, weiter...
Author: Koller DL, Liu L, Alam I, Sun Q, Econs MJ, Foroud T, Turner CH
Source: J Bone Miner Res., 2008; 23(1): 41-7, PMID: 17907919
GID: 1395; Last update: 22.07.2008
Fundamental Studies (2008)
Genetic loci affecting bone structure and strength in inbred COP and DA rats
Previous studies have shown that the Copenhagen 2331 (COP) and Dark Agouti (DA) rats have significant differences in bone structure and strength despite their similar body mass. Thus, these inbred rat strains m weiter...
Author: Sun Q, Alam I, Liu L, Koller DL, Carr LG, Econs MJ, Foroud T, Turner CH
Source: Bone., 2008; 42(3): 547-53, PMID: 18158281
GID: 1394; Last update: 22.07.2008
Fundamental Studies (2008)
Impact of pregnancy-associated plasma protein-a deletion on the adult murine skeleton
INTRODUCTION: The metalloproteinase, pregnancy-associated plasma protein-A (PAPP-A) functions to enhance local insulin-like growth factor (IGF)-I bioavailability through cleavage of inhibitory IGF binding pro weiter...
Author: Tanner SJ, Hefferan TE, Rosen CJ, Conover CA
Source: J Bone Miner Res., 2008; 23(5): 655-62, PMID: 18086007
GID: 1393; Last update: 22.07.2008
Fundamental Studies (2007)
Knee loading accelerates bone healing in mice
Knee loading is an anabolic loading modality that applies lateral loads to the knee. This study shows that loads applied to the proximal tibial epiphysis stimulate healing of surgically generated wounds in the weiter...
Author: Zhang P, Sun Q, Turner CH, Yokota H
Source: J Bone Miner Res., 2007; 22(12): 1979-87, PMID: 17696761
GID: 1392; Last update: 22.07.2008
Fundamental Studies (2008)
STUDY DESIGN: The measured maximum compressive force and stress of lumbar vertebral bodies from cynomolgus monkeys were compared with peripheral quantitative computed tomography (pQCT) derived densitometric and weiter...
Author: Dickerson CR, Saha S, Hotchkiss CE
Source: Spine., 2008; 33(4): 366-72, PMID: 18277866
GID: 1391; Last update: 22.07.2008
Fundamental Studies (2008)
The vitamin D endocrine system is important for skeletal homeostasis. 1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] impacts bone indirectly by promoting intestinal absorption of calcium and phosphate and directl weiter...
Author: Sutton AL, Zhang X, Dowd DR, Kharode YP, Komm BS, Macdonald PN
Source: Mol Endocrinol., 2008; 22(6): 1370-81, PMID: 18356290
GID: 1390; Last update: 22.07.2008
Fundamental Studies (2008)
Serum procollagen I N-terminal propeptide (PINP) is a sensitive bone formation marker in humans. We have developed a nonradioactive immunoassay for rat PINP and studied PINP as a bone formation marker in the ra weiter...
Author: Rissanen JP, Suominen MI, Peng Z, Morko J, Rasi S, Risteli J, Halleen JM
Source: Calcif Tissue Int., 2008; 82(2): 155-61, PMID: 18219436
GID: 1389; Last update: 22.07.2008
Fundamental Studies (2007)
Long chain polyunsaturated fatty acids (LCPUFAs) are involved in the regulation of bone metabolism. Increased dietary consumption of n-3, and possibly some n-6, LCPUFAs may limit postmenopausal bone loss. The a weiter...
Author: Poulsen RC, Firth EC, Rogers CW, Moughan PJ, Kruger MC
Source: Calcif Tissue Int., 2007; 81(6): 459-71, PMID: 18008020
GID: 1388; Last update: 22.07.2008
Fundamental Studies (2008)
A technique for computed tomography (CT) of the foot in the standing horse
Computed tomography (CT) in equine orthopaedics is currently limited because of the price, availability, impossibility to transport the scanner into surgical theatre, and the contraindications of general anaest weiter...
Author: FG Desbrosse, JMEF Vanderweerd, RA Perrin, PD Clegg, MT Launois, L Brogniez, SP Gehin
Source: Equine Veterinary Education, 2008; 20: 1 - 6
GID: 1387; Last update: 22.07.2008
Fundamental Studies (2008)
Replacement of bone marrow by bone in rat femurs: the bone bioreactor
During development and repair of bone, two distinct yet complementary mechanisms, intramembranous and endochondral, mediate new bone formation via osteoblasts. Because mechanical bone marrow ablation leads to t weiter...
Author: Zhang Q, Cuartas E, Mehta N, Gilligan J, Ke HZ, Saltzman WM, Kotas M, Ma M, Rajan S, Chalouni C, Carlson J, Vignery A
Source: Tissue Eng Part A., 2008; 14(2): 237-46, PMID: 18333776
GID: 1386; Last update: 22.07.2008
Fundamental Studies (2008)
Estrogen (E) is critical for the maintenance of bone mass in both female and male mice and steroid receptor coactivator (SRC)-1 has been shown to be important for mediating E effects on bone, at least in female weiter...
Author: Mödder UI, Sanyal A, Xu J, O"Malley BW, Spelsberg TC, Khosla S
Source: Bone., 2008; 42(2): 414-21, PMID: 18055287
GID: 1385; Last update: 22.07.2008
Fundamental Studies (2008)
TIEG-null mice display an osteopenic gender-specific phenotype
TGFbeta inducible early gene-1 (TIEG) was originally cloned from human osteoblasts (OB) and has been shown to play an important role in TGFbeta/Smad signaling, regulation of gene expression and OB growth and di weiter...
Author: Hawse JR, Iwaniec UT, Bensamoun SF, Monroe DG, Peters KD, Ilharreborde B, Rajamannan NM, Oursler MJ, Turner RT, Spelsberg TC, Subramaniam M
Source: Bone., 2008; 42(6): 1025-31, PMID: 18396127
GID: 1384; Last update: 22.07.2008
Fundamental Studies (2008)
Experimental tibial lengthening was achieved in 61 rabbits to examine the effect of continuous local infusion of recombinant human fibroblast growth factor-2 (rhFGF-2) on bone healing of the lengthened segment. weiter...
Author: Abbaspour A, Takata S, Sairyo K, Katoh S, Yukata K, Yasui N
Source: Bone., 2008; 42(1): 98-106, PMID: 17939975
GID: 1383; Last update: 22.07.2008
Fundamental Studies (2008)
Vibrational loading can stimulate the formation of new trabecular bone or maintain bone mass. Studies investigating vibrational loading have often used whole-body vibration (WBV) as their loading method. Howeve weiter...
Author: Christiansen BA, Bayly PV, Silva MJ
Source: J Biomech Eng., 2008; 130(4): 044502, PMID: 18601464
GID: 1366; Last update: 11.07.2008
Fundamental Studies (2007)
The uPAR and its ligand uPA are expressed by both osteoblasts and osteoclasts. Their function in bone remodeling is unknown. We report that uPAR-lacking mice display increased BMD, increased osteogenic potentia weiter...
Author: Furlan F, Galbiati C, Jorgensen NR, Jensen JE, Mrak E, Rubinacci A, Talotta F, Verde P, Blasi F
Source: J Bone Miner Res., 2007; 22(9): 1387-96, PMID: 17539736
GID: 1072; Last update: 01.02.2008
Fundamental Studies (2007)
Phenotype-driven mutagenesis approach in the mouse holds much promise as a method for revealing gene function. Earlier, we have described an N-ethyl-N-nitrosourea (ENU) mutagenesis screen to create genome-wide weiter...
Author: Mohan S, Chest V, Chadwick RB, Wergedal JE, Srivastava AK
Source: Bone., 2007; 41(5): 860-8, PMID: 17884746
GID: 1073; Last update: 01.02.2008
Fundamental Studies (2006)
Objectives: Orchidectomy (orx) of rats increases bone metabolism, the activity of osteoclasts more than of osteoblasts which results in osteoporosis. As testosterone (T) may be metabolized to estrogens, the eff weiter...
Author: D Seidlova-Wuttke, KM Stürmer, S Sehmisch, W Wuttke
Source: Maturitas, 2006; 55s: 64-74
GID: 1074; Last update: 01.02.2008
Fundamental Studies (2007)
Author: Firth EC, Rogers CW, van Weeren PR, Barneveld A, Kawcak CE, McIlwraith CW, Goodship AE, Smith RK
Source: J Musculoskelet Neuronal Interact., 2007; 7(1): 74-6, PMID: 17396010
GID: 933; Last update: 24.01.2008
More information: Original Article
Fundamental Studies (2006)
Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading
Estrogen and exercise influence cortical bone formation. Both affect bone during growth, but with complex interactions. We hypothesized that estrogen reduces the osteogenic response caused by exercise at the pe weiter...
Author: Saxon LK, Turner CH
Source: Bone., 2006; 39(6): 1261-7, PMID: 16934543
GID: 927; Last update: 24.01.2008
Fundamental Studies (2006)
Recent evidence has demonstrated that long-term estrogen deprivation using aromatase inhibitor therapy in postmenopausal women with breast cancer results in bone loss and increased fracture risk. Bisphosphonate weiter...
Author: Gasser JA, Green JR, Shen V, Ingold P, Rebmann A, Bhatnagar AS, Evans DB
Source: Bone., 2006; 39(4): 787-95, PMID: 16844441
GID: 929; Last update: 24.01.2008
Fundamental Studies (2007)
Effects of loss of classical estrogen response element signaling on bone in male mice
The role of estrogen signaling in the male skeleton via estrogen receptor (ER)-alpha is now well established. ERalpha can elicit responses through either classical estrogen response elements (ERE) pathways or n weiter...
Author: Syed FA, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, Khosla S
Source: Endocrinology., 2007; 148(4): 1902-10, PMID: 17204553
GID: 930; Last update: 24.01.2008
Fundamental Studies (2007)
Mutations in filamin B (FLNB), a gene encoding a cytoplasmic actin-binding protein, have been found in human skeletal disorders, including boomerang dysplasia, spondylocarpotarsal syndrome, Larsen syndrome, and weiter...
Author: Zhou X, Tian F, Sandzén J, Cao R, Flaberg E, Szekely L, Cao Y, Ohlsson C, Bergo MO, Borén J, Akyürek LM
Source: Proc Natl Acad Sci U S A., 2007; 104(10): 3919-24, PMID: 17360453
GID: 931; Last update: 24.01.2008
Fundamental Studies (2007)
Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific
Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone"s mechanical environment. Male mice have a greater response to non-weight-b weiter...
Author: Wallace JM, Rajachar RM, Allen MR, Bloomfield SA, Robey PG, Young MF, Kohn DH
Source: Bone., 2007; 40(4): 1120-7, PMID: 17240210
GID: 932; Last update: 24.01.2008
Fundamental Studies (2006)
Mesenchymal stem cells (MSCs) were demonstrated to exist within peripheral blood (PB) of several mammalian species including human, guinea pig, mice, rat, and rabbit. Whether or not the PB derived MSCs (PBMSCs) weiter...
Author: Wan C, He Q, Li G
Source: J Orthop Res., 2006; 24(4): 610-8, PMID: 16514623
GID: 934; Last update: 24.01.2008
Fundamental Studies (2007)
INTRODUCTION: Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug therapies should discontinue treatment after sustaining a non-vertebral fracture weiter...
Author: Cao Y, Mori S, Mashiba T, Kaji Y, Manabe T, Iwata K, Miyamoto K, Komatsubara S, Yamamoto T
Source: Bone., 2007; 40(1): 132-9, PMID: 16962400
GID: 935; Last update: 24.01.2008
Fundamental Studies (2007)
The biostimulatory effects of laser irradiation focus not only in the field of soft tissue but also bone formation. Studies have shown that the light of a nanosecond pulsed laser which has a high peak power can weiter...
Author: Ninomiya T, Hosoya A, Nakamura H, Sano K, Nishisaka T, Ozawa H
Source: Bone., 2007; 40(1): 140-8, PMID: 16978938
GID: 936; Last update: 24.01.2008
Fundamental Studies (2007)
Most previous studies to identify loci involved in bone mineral density (BMD) regulation have used inbred strains with high and low BMD in generating F(2) mice. However, differences in BMD may not be a requirem weiter...
Author: Yu H, Mohan S, Edderkaoui B, Masinde GL, Davidson HM, Wergedal JE, Beamer WG, Baylink DJ
Source: Calcif Tissue Int., 2007; 80(2): 103-10, PMID: 17308992
GID: 937; Last update: 24.01.2008
Fundamental Studies (2006)
AIM: To examine the effectiveness of administering recombinant human bone morphogenetic protein-2 (rhBMP-2) in distraction osteogenesis. MATERIAL AND METHODS: Twenty-one mature male Japanese white rabbits under weiter...
Author: Yonezawa H, Harada K, Ikebe T, Shinohara M, Enomoto S
Source: J Craniomaxillofac Surg., 2006; 34(5): 270-6, PMID: 16790354
GID: 938; Last update: 24.01.2008
Fundamental Studies (2007)
Reduced estrogen levels occurring during menopause in women are accompanied by a variety of disorders, e.g. hot flushes, depressions, osteoporosis, increase in body weight and reduced movement drive. The phytoe weiter...
Author: Hertrampf T, Gruca MJ, Seibel J, Laudenbach U, Fritzemeier KH, Diel P
Source: Bone., 2007; 40(6): 1529-35, PMID: 17383949
GID: 939; Last update: 24.01.2008
Fundamental Studies (2001)
Chromosome 13 locus, Pbd2, regulates bone density in mice
Bone density is inherited as a complex polygenic trait. Previously, we identified two quantitative trait loci (QTLs) specifying the peak relative bone mass (bone mass corrected by bone size) on chromosomes (Chr weiter...
Author: Shimizu M, Higuchi K, Kasai S, Tsuboyama T, Matsushita M, Mori M, Shimizu Y, Nakamura T, Hosokawa M
Source: J Bone Miner Res., 2001; 16(11): 1972-82, PMID: 11697793
GID: 940; Last update: 24.01.2008
Fundamental Studies (2005)
Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene
COX-2 is a key enzyme involved in the response of bone to loading. However, using mice with a null mutation of the COX-2 gene, we found that a functional COX-2 gene is not required for mechanotransduction. This weiter...
Author: Alam I, Warden SJ, Robling AG, Turner CH
Source: J Bone Miner Res., 2005; 20(3): 438-46, PMID: 15746988
GID: 941; Last update: 24.01.2008
Fundamental Studies (2005)
Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance
Using a mechanical loading program to induce bone adaptation, we found that small (<2-fold) changes in the structural properties of the rat ulna increased its fatigue resistance >100-fold. This indicates that a weiter...
Author: Warden SJ, Hurst JA, Sanders MS, Turner CH, Burr DB, Li J
Source: J Bone Miner Res., 2005; 20(5): 809-16, PMID: 15824854
GID: 942; Last update: 24.01.2008
Fundamental Studies (2005)
Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta
Systemic growth hormone injections increased spine and femur length in a mouse model of OI. Femur BMC, cross-sectional area, and BMD were increased. Smaller gains were produced in vertebral BMC and cross-sectio weiter...
Author: King D, Jarjoura D, McEwen HA, Askew MJ
Source: J Bone Miner Res., 2005; 20(6): 987-93, PMID: 15883639
GID: 943; Last update: 24.01.2008
Fundamental Studies (2005)
Using a dominant ENU mutagenesis screen in C57BL/6J (B6) mice to reveal gene function, we identified a mutant, 917M, with a reduced bone size phenotype, which is expressed only in males. We show that mutation r weiter...
Author: Srivastava AK, Kapur S, Mohan S, Yu H, Kapur S, Wergedal J, Baylink DJ
Source: J Bone Miner Res., 2005; 20(6): 1041-50, PMID: 15883645
GID: 944; Last update: 24.01.2008
Fundamental Studies (2005)
Type XIII collagen strongly affects bone formation in transgenic mice
To characterize the function of type XIII collagen, a transmembrane protein occurring at cell adhesion sites, we generated transgenic mice overexpressing it. High transgene expression was detected in cartilage weiter...
Author: Ylönen R, Kyrönlahti T, Sund M, Ilves M, Lehenkari P, Tuukkanen J, Pihlajaniemi T
Source: J Bone Miner Res., 2005; 20(8): 1381-93, PMID: 16007336
GID: 945; Last update: 24.01.2008
Fundamental Studies (2006)
Skeletal phenotype analyses of 10 B6.CAST-1 congenic sublines of mice have revealed evidence for the presence of three closely linked QTLs in Chr 1 that influence femoral vBMD both positively and negatively. IN weiter...
Author: Edderkaoui B, Baylink DJ, Beamer WG, Wergedal JE, Dunn NR, Shultz KL, Mohan S
Source: J Bone Miner Res., 2006; 21(1): 97-104, PMID: 16355278
GID: 946; Last update: 24.01.2008
Fundamental Studies (2006)
We developed a cyclic PTH regimen with repeated cycles of 1-week on and off daily PTH injection and explored its effects on bone strength, BMD, bone markers, and bone structure in mice. Cyclic protocols produce weiter...
Author: Iida-Klein A, Hughes C, Lu SS, Moreno A, Shen V, Dempster DW, Cosman F, Lindsay R
Source: J Bone Miner Res., 2006; 21(2): 274-82, PMID: 16418783
GID: 947; Last update: 24.01.2008
Fundamental Studies (2006)
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass
Wnt/beta-catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast differentiation and mineralized matrix formation. We weiter...
Author: Morvan F, Boulukos K, Clément-Lacroix P, Roman Roman S, Suc-Royer I, Vayssière B, Ammann P, Martin P, Pinho S, Pognonec P, Mollat P, Niehrs C, Baron R, Rawadi G
Source: J Bone Miner Res., 2006; 21(6): 934-45, PMID: 16753024
GID: 948; Last update: 24.01.2008
Fundamental Studies (2006)
Genetic analysis of an NZB/B1NJ x RF/J cross has identified QTLs for femur mechanical, geometric, and densitometric phenotypes. Most mechanical QTLs were associated with geometric QTLs, strongly suggesting comm weiter...
Author: Wergedal JE, Ackert-Bicknell CL, Tsaih SW, Sheng MH, Li R, Mohan S, Beamer WG, Churchill GA, Baylink DJ
Source: J Bone Miner Res., 2006; 21(8): 1256-66, PMID: 16869724
GID: 949; Last update: 24.01.2008
Fundamental Studies (2006)
The liver X receptor (alpha,beta) is responsible for regulating cholesterol homeostasis in cells. However, our studies using the LXRalpha-/-, LXRbeta-/-, and LXRalpha-/-beta-/- mice show that both LXRalpha and weiter...
Author: Robertson KM, Norgård M, Windahl SH, Hultenby K, Ohlsson C, Andersson G, Gustafsson JA
Source: J Bone Miner Res., 2006; 21(8): 1276-87, PMID: 16869726
GID: 950; Last update: 24.01.2008
Fundamental Studies (2007)
Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty
The interaction between androgens and GH/IGF-I was studied in male GHR gene disrupted or GHRKO and WT mice during puberty. Androgens stimulate trabecular and cortical bone modeling and increase muscle mass even weiter...
Author: Venken K, Movérare-Skrtic S, Kopchick JJ, Coschigano KT, Ohlsson C, Boonen S, Bouillon R, Vanderschueren D
Source: J Bone Miner Res., 2007; 22(1): 72-82, PMID: 17014385
GID: 951; Last update: 24.01.2008
Fundamental Studies (2007)
High dietary phosphate intake reduces bone strength in the growing rat skeleton
Nutrition influences peak bone mass development in early adulthood. The effect of high dietary phosphate intake on the growing skeleton of 1-month-old male rats (n = 30) was assessed in an 8-week intervention. weiter...
Author: Huttunen MM, Tillman I, Viljakainen HT, Tuukkanen J, Peng Z, Pekkinen M, Lamberg-Allardt CJ
Source: J Bone Miner Res., 2007; 22(1): 83-92, PMID: 17042736
GID: 952; Last update: 24.01.2008
Fundamental Studies (2007)
Exercise when young provides lifelong benefits to bone structure and strength
Short-term exercise in growing rodents provided lifelong benefits to bone structure, strength, and fatigue resistance. Consequently, exercise when young may reduce the risk for fractures later in life, and the weiter...
Author: Warden SJ, Fuchs RK, Castillo AB, Nelson IR, Turner CH
Source: J Bone Miner Res., 2007; 22(2): 251-9, PMID: 17129172
GID: 953; Last update: 24.01.2008
Fundamental Studies (2007)
Histomorphometric studies of treatments for osteoporosis in humans are restricted to iliac crest biopsies. We studied the effects of PTH(1-84) treatment at the lumbar spine of skeletally mature ovariectomized r weiter...
Author: Fox J, Miller MA, Newman MK, Turner CH, Recker RR, Smith SY
Source: J Bone Miner Res., 2007; 22(2): 260-73, PMID: 17087625
GID: 954; Last update: 24.01.2008
Fundamental Studies (2007)
With chicken used as a model species, we used QTL analysis to examine the genetic contribution to bone traits. We report the identification of four QTLs for femoral traits: one for bone strength, one for endost weiter...
Author: Rubin CJ, Brändström H, Wright D, Kerje S, Gunnarsson U, Schutz K, Fredriksson R, Jensen P, Andersson L, Ohlsson C, Mallmin H, Larsson S, Kindmark A
Source: J Bone Miner Res., 2007; 22(3): 375-84, PMID: 17181401
GID: 955; Last update: 24.01.2008
Fundamental Studies (2003)
Thus far, orthopedic research lacks a suitable animal model of osteoporosis. In OVX sheep, 6 months of steroid exposure reduced bone density and mechanical competence. Bone properties and bone formation did not weiter...
Author: Schorlemmer S, Gohl C, Iwabu S, Ignatius A, Claes L, Augat P
Source: J Bone Miner Res., 2003; 18(11): 2010-5, PMID: 14606514
GID: 956; Last update: 24.01.2008
Fundamental Studies (2003)
CP-533,536, a newly discovered, non-prostanoid EP2 receptor-selective PGE2 agonist, stimulates local bone formation and enhances fracture healing in rat models. INTRODUCTION: There is a significant medical need weiter...
Author: Li M, Ke HZ, Qi H, Healy DR, Li Y, Crawford DT, Paralkar VM, Owen TA, Cameron KO, Lefker BA, Brown TA, Thompson DD
Source: J Bone Miner Res., 2003; 18(11): 2033-42, PMID: 14606517
GID: 957; Last update: 24.01.2008
Fundamental Studies (2007)
A cyclic PTH regimen is as effective as a daily regimen on bone density gain in humans and in improving bone quality in mice. Our previous murine study evaluated the effects of a cyclic PTH regimen in the absen weiter...
Author: Johnston S, Andrews S, Shen V, Cosman F, Lindsay R, Dempster DW, Iida-Klein A
Source: Endocrinology., 2007; 148(9): 4466-74, PMID: 17569757
GID: 958; Last update: 24.01.2008
Fundamental Studies (2003)
Age-change of bone mineral density in the distal radius of chimpanzees and japanese macaques
Using peripheral quantitative computed tomography (pQCT), we evaluated and analyzed age-related changes in bone mineral density and other properties at the site of the distal radius in two catarrhines: chimpanz weiter...
Author: Kikuchi Y
Source: Anthropological Science, 2003; 111: 165-86
GID: 960; Last update: 24.01.2008
Fundamental Studies (2005)
Estradiol (E2) and testosterone (T) effectively prevent orchidectomy (orx) induced osteoporosis. T, however, stimulates prostate proliferation which may lead to malignancy. We showed that a Cimicifuga racemosa weiter...
Author: Seidlová-Wuttke D, Jarry H, Pitzel L, Wuttke W
Source: Maturitas., 2005; 51(2): 177-86, PMID: 15917159
GID: 961; Last update: 24.01.2008
Fundamental Studies (2007)
The findings that sex-specific effects on femoral structure and peak bone mineral density (BMD) are linked to quantitative trait loci (QTL) provide evidence for the involvement of specific genes that contribute weiter...
Author: Edderkaoui B, Baylink DJ, Beamer WG, Shultz KL, Wergedal JE, Mohan S
Source: Bone., 2007; 41(3): 340-5, PMID: 17618849
GID: 962; Last update: 24.01.2008
Fundamental Studies (2007)
Treatment with parathyroid hormone 1-84 (PTH) or teriparatide increases osteonal remodeling and decreases bone mineral density (BMD) at cortical (Ct) bone sites but may also increase bone size. Decreases in BMD weiter...
Author: Fox J, Miller MA, Newman MK, Recker RR, Turner CH, Smith SY
Source: Bone., 2007; 41(3): 321-30, PMID: 17573250
GID: 963; Last update: 24.01.2008
Fundamental Studies (2007)
Treatment of monkeys and humans with parathyroid hormone (PTH) 1-84 stimulates skeletal remodeling, which increases trabecular (Tb) bone mineral density (BMD) but decreases cortical (Ct) BMD at locations where weiter...
Author: Fox J, Miller MA, Recker RR, Turner CH, Smith SY
Source: Calcif Tissue Int., 2007; 81(1): 53-63, PMID: 17551766
GID: 964; Last update: 24.01.2008
Fundamental Studies (2004)
Quantitative analyses of cross-sectional shape of the distal radius in three species of macaques
I conducted quantitative analyses of the cross-sectional shape of the distal radial shaft in three species of macaques, which differ in locomotor behavior: semi-terrestrial Japanese macaques ( Macaca fuscata), weiter...
Author: Kikuchi Y
Source: Primates., 2004; 45(2): 129-34, PMID: 14685819
GID: 965; Last update: 24.01.2008
Fundamental Studies (2007)
Fat and bone metabolism are two linked processes regulated by several hormonal factors. Fetal antigen 1 (FA1) is the soluble form of dlk1 (delta-like 1), which is a member of the Notch-Delta family. We previous weiter...
Author: Abdallah BM, Ding M, Jensen CH, Ditzel N, Flyvbjerg A, Jensen TG, Dagnaes-Hansen F, Gasser JA, Kassem M
Source: Endocrinology., 2007; 148(7): 3111-21, PMID: 17446189
GID: 966; Last update: 24.01.2008
Fundamental Studies (2007)
Decreased bone mass and bone strength can result from excess alcohol consumption in humans and alcohol treatment in the rat. Although the specific mechanism is unknown, the damaging effects of alcohol abuse mod weiter...
Author: Wezeman FH, Juknelis D, Himes R, Callaci JJ
Source: Bone., 2007; 41(4): 639-45, PMID: 17643361
GID: 967; Last update: 24.01.2008
Fundamental Studies (2007)
Segmental defect regeneration has been a clinical challenge. Current tissue-engineering approach using porous biodegradable scaffolds to delivery osteogenic cells and growth factors demonstrated success in faci weiter...
Author: Chu TM, Warden SJ, Turner CH, Stewart RL
Source: Biomaterials., 2007; 28(3): 459-67, PMID: 16996588
GID: 968; Last update: 24.01.2008
Fundamental Studies (2007)
Experimental studies as well as studies in free-ranging animals have shown that endocrine-disrupting chemicals (EDCs) impair bone tissue composition and strength. The aim of the present study was to expand our weiter...
Author: Lundberg R, Jenssen BM, Leiva-Presa A, Rönn M, Hernhag C, Wejheden C, Larsson S, Orberg J, Lind PM
Source: J Toxicol Environ Health A., 2007; 70(7): 614-9, PMID: 17365615
GID: 969; Last update: 24.01.2008
Fundamental Studies (2007)
Ovariectomy worsens secondary hyperparathyroidism in mature rats during low-Ca diet
Estrogen deficiency impairs intestinal Ca absorption and induces bone loss, but its effects on the vitamin D-endocrine system are unclear. In the present study, calciotropic hormones levels, renal vitamin D met weiter...
Author: Zhang Y, Lai WP, Wu CF, Favus MJ, Leung PC, Wong MS
Source: Am J Physiol Endocrinol Metab., 2007; 292(3): E723-31, PMID: 17077343
GID: 970; Last update: 24.01.2008
Fundamental Studies (2007)
Reduced cortical bone mass in mice with inactivation of interleukin-4 and interleukin-13
The aim of the present study was to study the in vivo role of IL-4 and IL-13 on bone metabolism. The skeletal phenotypes of male and female IL-13(-/-) (n = 7+7), IL-4(-/-)IL-13(-/-) (n = 7+7), and WT (n = 7+7) weiter...
Author: Silfverswärd CJ, Larsson S, Ohlsson C, Frost A, Nilsson O
Source: J Orthop Res., 2007; 25(6): 725-31, PMID: 17318894
GID: 971; Last update: 24.01.2008
Fundamental Studies (2007)
Substantial losses of skeletal tissue occur during late pregnancy and lactation. The goal of the present study was to follow these changes in pregnant and lactating goats and sheep, compare these two species du weiter...
Author: Liesegang A, Risteli J, Wanner M
Source: J Anim Physiol Anim Nutr (Berl)., 2007; 91(5-6): 217-25, PMID: 17516943
GID: 972; Last update: 24.01.2008
Fundamental Studies (2004)
Contradictory results whether the endocrine disrupters (ED) benzophenone-2 (BP2), bisphenol A (BPA) and dibutylphtalate (DBP) exert estrogenic effects have been published. Selective estrogen receptor modulators weiter...
Author: Seidlová-Wuttke D, Jarry H, Wuttke W
Source: Toxicology., 2004; 205(1-2): 103-12, PMID: 15458795
GID: 877; Last update: 23.01.2008
Fundamental Studies (2005)
We studied the effects of grape seed proanthocyanidins extract (GSPE) given as a ratio of 3 mg in 100 g in a standard diet, on the tibial bone diaphysis in low-calcium fed rats. Measurements of bone density, mi weiter...
Author: Yahara N, Tofani I, Maki K, Kojima K, Kojima Y, Kimura M
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 162-9, PMID: 15951633
GID: 878; Last update: 23.01.2008
More information: Original Article
Fundamental Studies (2005)
The effect of oral ipriflavone on the rat mandible during growth
Different types of ipriflavone (IF) have been reported to be effective when used as a remedy for bone loss due to osteoporosis. However, no information is available regarding the relationship between IF and jaw weiter...
Author: Maki K, Nishida I, Kimura M
Source: Eur J Orthod., 2005; 27(1): 27-31, PMID: 15743860
GID: 879; Last update: 23.01.2008
Fundamental Studies (2005)
Reduced bone mineral density in SOCS-2-deficient mice
Suppressor of cytokine signaling-2 (SOCS-2) is a member of the suppressor of cytokine signaling family, implicated in the negative regulation of cytokine action through inhibition of the Janus kinase (JAK) sign weiter...
Author: Lorentzon M, Greenhalgh CJ, Mohan S, Alexander WS, Ohlsson C
Source: Pediatr Res., 2005; 57(2): 223-6, PMID: 15585682
GID: 880; Last update: 23.01.2008
Fundamental Studies (2005)
The effect of a simultaneous dietary administration of xylitol and ethanol on bone resorption
Our previous studies have shown that dietary xylitol supplementation diminishes bone resorption in rats, as well as protects against ovariectomy-induced increase of bone resorption during experimental osteoporo weiter...
Author: Mattila PT, Kangasmaa H, Knuuttila ML
Source: Metabolism., 2005; 54(4): 548-51, PMID: 15798965
GID: 881; Last update: 23.01.2008
Fundamental Studies (2005)
Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity
We assessed the preclinical characteristics of a novel, stringently screened selective estrogen receptor modulator, bazedoxifene acetate, including its ability to bind to and activate estrogen receptors and pro weiter...
Author: Komm BS, Kharode YP, Bodine PV, Harris HA, Miller CP, Lyttle CR
Source: Endocrinology., 2005; 146(9): 3999-4008, PMID: 15961563
GID: 882; Last update: 23.01.2008
Fundamental Studies (2005)
This study reports the preclinical evaluation of the bone and muscle protective potential of the synthetic androgen 7alpha-methyl-19-nortestosterone (MENTtrade mark), as assessed in the aged orchidectomized rat weiter...
Author: Venken K, Boonen S, Van Herck E, Vandenput L, Kumar N, Sitruk-Ware R, Sundaram K, Bouillon R, Vanderschueren D
Source: Bone., 2005; 36(4): 663-70, PMID: 15784189
GID: 883; Last update: 23.01.2008
Fundamental Studies (2005)
Differential turnover of cortical and trabecular bone in transgenic mice overexpressing cathepsin K
Cathepsin K is a major osteoclastic protease. We have recently shown that overexpression of mouse cathepsin K gene in transgenic UTU17 mouse model results in high turnover osteopenia of metaphyseal trabecular b weiter...
Author: Morko J, Kiviranta R, Hurme S, Rantakokko J, Vuorio E
Source: Bone., 2005; 36(5): 854-65, PMID: 15826870
GID: 884; Last update: 23.01.2008
Fundamental Studies (2005)
Changes in total bone mineral density determined by the bone-ash method were recently demonstrated in rats, exposed to Herring oil from the contaminated southern part of the Baltic Sea. In the present study mor weiter...
Author: Stern N, Korotkova M, Strandvik B, Oxlund H, Oberg M, Håkansson H, Lind PM
Source: Basic Clin Pharmacol Toxicol., 2005; 96(6): 453-64, PMID: 15910409
GID: 885; Last update: 23.01.2008
Fundamental Studies (2005)
This study aimed to test whether intermittent treatment of human parathyroid hormone [hPTH(1-34)] disturbs or accelerates the fracture healing process using rat surgical osteotomy model. One hundred five, 5-wee weiter...
Author: Komatsubara S, Mori S, Mashiba T, Nonaka K, Seki A, Akiyama T, Miyamoto K, Cao Y, Manabe T, Norimatsu H
Source: Bone., 2005; 36(4): 678-87, PMID: 15781006
GID: 886; Last update: 23.01.2008
Fundamental Studies (2005)
Mice deficient for all known thyroid hormone receptors, TRalpha1-/-beta-/- mice, display a clear skeletal phenotype characterized by growth retardation, delayed maturation of long bones and decreased trabecular weiter...
Author: Kindblom JM, Gevers EF, Skrtic SM, Lindberg MK, Göthe S, Törnell J, Vennström B, Ohlsson C
Source: Bone., 2005; 36(4): 607-16, PMID: 15780976
GID: 887; Last update: 23.01.2008
Fundamental Studies (2005)
Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation. The present study examined the long-term effects of targeted PTN over-expression o weiter...
Author: Li G, Bunn JR, Mushipe MT, He Q, Chen X
Source: Calcif Tissue Int., 2005; 76(4): 299-306, PMID: 15812580
GID: 888; Last update: 23.01.2008
Fundamental Studies (2005)
Macaque lumber posterolateral spine fusion (PLF) was performed by using beta-TCP graft combined with bone marrow derived stromal cells (MSCs), to evaluate whether a beta-TCP/MSCs hybrid can be used for PLF inst weiter...
Author: Orii H, Sotome S, Chen J, Wang J, Shinomiya K
Source: J Med Dent Sci., 2005; 52(1): 51-7, PMID: 15868741
GID: 889; Last update: 23.01.2008
Fundamental Studies (2005)
Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice
The EP4 receptor, one of the subtypes of the prostaglandin E2 (PGE2) receptor, plays a critical role in the anabolic effects of PGE2 on bone. However, its role in the maintenance of bone mass in aged animals an weiter...
Author: Li M, Healy DR, Li Y, Simmons HA, Crawford DT, Ke HZ, Pan LC, Brown TA, Thompson DD
Source: Bone., 2005; 37(1): 46-54, PMID: 15869929
GID: 890; Last update: 23.01.2008
Fundamental Studies (2005)
The objective of this study was to evaluate the influence of heterozygous inactivation of one allele of the type II collagen gene (Col2a1) on biomechanical properties and mineral density of bone under physical weiter...
Author: Nieminen J, Sahlman J, Hirvonen T, Jämsä T, Tuukkanen J, Kovanen V, Kröger H, Jurvelin J, Arita M, Li SW, Prockop DJ, Hyttinen MM, Helminen HJ, Lapveteläinen T, Puustjärvi K
Source: Calcif Tissue Int., 2005; 77(2): 104-12, PMID: 15920676
GID: 891; Last update: 23.01.2008
Fundamental Studies (2005)
Raloxifene and vitamin K2 combine to improve the femoral neck strength of ovariectomized rats
We evaluated the skeletal effects of two osteoporosis therapies in an ovariectomized rat model, raloxifene and vitamin K2, as well as the vitamin K2 plus raloxifene (K + Ral) combination. In two studies, 6-mont weiter...
Author: Iwamoto J, Yeh JK, Schmidt A, Rowley E, Stanfield L, Takeda T, Sato M
Source: Calcif Tissue Int., 2005; 77(2): 119-26, PMID: 16059775
GID: 892; Last update: 23.01.2008
Fundamental Studies (2004)
Problems in quantifying bone response to exercise in horses: a review
Detecting changes in bone during growth, training, rest from competition (spelling), and disease in horses requires imaging techniques that have a high level of accuracy and precision. Currently, most imaging t weiter...
Author: Firth EC
Source: N Z Vet J., 2004; 52(5): 216-29, PMID: 15768116
GID: 893; Last update: 23.01.2008
Fundamental Studies (2006)
COX-2 is necessary for venous ligation-mediated bone adaptation in mice
In osteoblasts, cyclooxygenase 2 (COX-2) is the major isozyme responsible for production of prostaglandins. Prostaglandins are local mediators of bone resorption and formation and are known to be involved in bo weiter...
Author: Stevens HY, Meays DR, Yeh J, Bjursten LM, Frangos JA
Source: Bone., 2006; 38(1): 93-104, PMID: 16122997
GID: 894; Last update: 23.01.2008
Fundamental Studies (2006)
Different molecular mechanisms underlie ethanol-induced bone loss in cycling and pregnant rats
Chronic ethanol (EtOH) consumption can result in osteopenia. In the current study, we examined the modulation of EtOH-induced bone loss during pregnancy. Nonpregnant and pregnant dams were intragastrically infu weiter...
Author: Shankar K, Hidestrand M, Haley R, Skinner RA, Hogue W, Jo CH, Simpson P, Lumpkin CK Jr, Aronson J, Badger TM, Ronis MJ
Source: Endocrinology., 2006; 147(1): 166-78, PMID: 16239303
GID: 895; Last update: 23.01.2008
Fundamental Studies (2006)
Aromatase is the sole enzyme which converts androgen into estrogen. We have reported that aromatase-knockout (ArKO) mice showed bone loss by increased bone resorption not only in female but also in male mice, s weiter...
Author: Matsumoto C, Inada M, Toda K, Miyaura C
Source: Bone., 2006; 38(2): 220-6, PMID: 16213803
GID: 896; Last update: 23.01.2008
Fundamental Studies (2006)
Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss
INTRODUCTION: Estrogen deficiency results in trabecular bone loss, associated with T-cell proliferation in the bone marrow. Insulin-like growth factor I (IGF-I) is involved in the regulation of both bone metabo weiter...
Author: Lindberg MK, Svensson J, Venken K, Chavoshi T, Andersson N, Movérare Skrtic S, Isaksson O, Vanderschueren D, Carlsten H, Ohlsson C
Source: Bone., 2006; 38(1): 85-92, PMID: 16257281
GID: 897; Last update: 23.01.2008
Fundamental Studies (2006)
In both clinical and experimental settings, access to quantitative methods enabling the objective evaluation of cortical bone mass, structure, geometry and strength are essential for the assessment of efficacy weiter...
Author: Bagi CM, Hanson N, Andresen C, Pero R, Lariviere R, Turner CH, Laib A
Source: Bone., 2006; 38(1): 136-44, PMID: 16301011
GID: 898; Last update: 23.01.2008
Fundamental Studies (2005)
AIM: To determine the effect of a known training regimen on the size and mineral content of the third metacarpal (Mc3) and third metatarsal (Mt3) bones of 2-year-old Thoroughbred horses trained on racetracks. M weiter...
Author: Firth EC, Rogers CW, Doube M, Jopson NB
Source: N Z Vet J., 2005; 53(2): 101-12, PMID: 15846394
GID: 899; Last update: 23.01.2008
Fundamental Studies (2005)
AIM: To describe features of the morphology of the carpus, quantify the thickness of hyaline and calcified cartilage, and to describe the morphology and density of subchondral bone in the third carpal bone (C3) weiter...
Author: Firth EC, Rogers CW
Source: N Z Vet J., 2005; 53(2): 113-22, PMID: 15846395
GID: 900; Last update: 23.01.2008
Fundamental Studies (2006)
Although testosterone (T) has striking effects on mature skeletal size and structure, it is not clear whether this depends exclusively on adult circulating levels of T or whether additional early-life factors a weiter...
Author: Sims NA, Brennan K, Spaliviero J, Handelsman DJ, Seibel MJ
Source: Am J Physiol Endocrinol Metab., 2006; 290(3): E456-62, PMID: 16204337
GID: 901; Last update: 23.01.2008
Fundamental Studies (2003)
AIMS: To measure the nutritive value of pasture in terms of digestible energy intake (DEI) and dry matter (DM) digestibility, and the effects of increased calcium (Ca) intakes on apparent mineral absorption and weiter...
Author: Grace ND, Rogers CW, Firth EC, Faram TL, Shaw HL
Source: N Z Vet J., 2003; 51(4): 165-73, PMID: 16032319
GID: 902; Last update: 23.01.2008
Fundamental Studies (2006)
Mature bone-resorbing osteoclasts (OCs) mediate excessive bone loss seen in several bone disorders, including osteoporosis. Here, we showed that reveromycin A (RM-A), a small natural product with three carboxyl weiter...
Author: Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Kanoh N, Nakagawa H, Takami M, Lee KH, Stern PH, Nagai K, Osada H
Source: Proc Natl Acad Sci U S A., 2006; 103(12): 4729-34, PMID: 16537392
GID: 903; Last update: 23.01.2008
Fundamental Studies (2006)
BACKGROUND: IGF-I is an important growth and differentiative factor for osteoblasts and may have a role in defining prostate cancer risk and skeletal metastases. METHODS: Conditioned media (CM) from human prost weiter...
Author: Rubin J, Fan X, Rahnert J, Sen B, Hsieh CL, Murphy TC, Nanes MS, Horton LG, Beamer WG, Rosen CJ
Source: Prostate., 2006; 66(8): 789-800, PMID: 16482567
GID: 904; Last update: 23.01.2008
Fundamental Studies (2006)
Chronic renal insufficiency (CRI) results in phosphate retention and secondary hyperparathyroidism, the treatment of which is largely based on the use of calcium salts as phosphate binders. Advanced CRI causes weiter...
Author: Jokihaara J, Järvinen TL, Jolma P, Kööbi P, Kalliovalkama J, Tuukkanen J, Saha H, Sievänen H, Kannus P, Pörsti I
Source: Bone., 2006; 39(2): 353-60, PMID: 16584934
GID: 905; Last update: 23.01.2008
Fundamental Studies (2006)
We examined whether regional differences in cortical bone mineral density (Ct.BMD) measured by peripheral quantitative computed tomography is related to the heterogeneity of bone tissue and whether regional Ct. weiter...
Author: Nonaka K, Fukuda S, Aoki K, Yoshida T, Ohya K
Source: Bone., 2006; 38(2): 265-72, PMID: 16213204
GID: 906; Last update: 23.01.2008
Fundamental Studies (2006)
Paricalcitol [19-nor-1,25-(OH)2D2] in the treatment of experimental renal bone disease
Paricalcitol is a less hypercalcemic vitamin D analog that has been shown to suppress secondary hyperparathyroidism and to prevent the associated histomorphometric changes in bone. In this study, we show that p weiter...
Author: Jokihaara J, Pörsti I, Pajamäki I, Vuohelainen T, Jolma P, Kööbi P, Kalliovalkama J, Niemelä O, Kannus P, Sievänen H, Järvinen TL
Source: J Bone Miner Res., 2006; 21(5): 745-51, PMID: 16734389
GID: 907; Last update: 23.01.2008
Fundamental Studies (2005)
FR167356, a novel inhibitor of vacuolar ATPase, has high potency against osteoclast V-ATPase and low potency against lysosomal V-ATPase. FR167356 is the first compound of this nature to be tested. It has the po weiter...
Author: Niikura K, Takeshita N, Takano M
Source: J Bone Miner Res., 2005; 20(9): 1579-88, PMID: 16059630
GID: 908; Last update: 23.01.2008
Fundamental Studies (2005)
ER alpha acts either through classical (ERE-mediated) or nonclassical (non-ERE) pathways. The generation of mice carrying a mutation that eliminates classical ER alpha signaling presents a unique opportunity to weiter...
Author: Syed FA, Mödder UI, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, Khosla S
Source: J Bone Miner Res., 2005; 20(11): 1992-2001, PMID: 16234973
GID: 909; Last update: 23.01.2008
Fundamental Studies (2005)
A new SERM, CHF 4227.01, given to 6-month-old female rats immediately after ovariectomy, preserved bone mass and bone microarchitecture without affecting uterus weight. It also decreased serum cholesterol and f weiter...
Author: Armamento-Villareal R, Sheikh S, Nawaz A, Napoli N, Mueller C, Halstead LR, Brodt MD, Silva MJ, Galbiati E, Caruso PL, Civelli M, Civitelli R
Source: J Bone Miner Res., 2005; 20(12): 2178-88, PMID: 16294271
GID: 910; Last update: 23.01.2008
Fundamental Studies (2006)
We identified quantitative trait loci (QTL) that determined the genetic variance in serum IGF-I through genome-wide scanning of mice derived from C57BL/6J(B6) x C3H/HeJ(C3H) intercrosses. One QTL (Igf1s2), on m weiter...
Author: Delahunty KM, Shultz KL, Gronowicz GA, Koczon-Jaremko B, Adamo ML, Horton LG, Lorenzo J, Donahue LR, Ackert-Bicknell C, Kream BE, Beamer WG, Rosen CJ
Source: Endocrinology., 2006; 147(8): 3915-23, PMID: 16675518
GID: 911; Last update: 23.01.2008
Fundamental Studies (2006)
Risk factors for osteoporotic hip fracture include reduced bone mineral density and poor structure of the femoral neck, both of which are heritable traits. Previously, we showed that despite similar body size, weiter...
Author: Alam I, Sun Q, Liu L, Koller DL, Fishburn T, Carr LG, Econs MJ, Foroud T, Turner CH
Source: Bone., 2006; 39(1): 93-9, PMID: 16461031
GID: 913; Last update: 23.01.2008
Fundamental Studies (2006)
The effects of first gestation and lactation on bone metabolism in dairy goats and milk sheep
The goal of the present study was to compare mobilization rate of calcium (Ca) from bone in pregnant and lactating goats and sheep. Blood samples were collected from goats and sheep monthly during pregnancy and weiter...
Author: Liesegang A, Risteli J, Wanner M
Source: Bone., 2006; 38(6): 794-802, PMID: 16364707
GID: 914; Last update: 23.01.2008
Fundamental Studies (2006)
Mediolateral three-point bending of the rat midfemur was developed to enable the assessment of the mechanical competence of the elliptic bone cross-section in terms of its widest diameter, the apparent primary weiter...
Author: Leppänen O, Sievänen H, Jokihaara J, Pajamäki I, Järvinen TL
Source: J Bone Miner Res., 2006; 21(8): 1231-7, PMID: 16869721
GID: 915; Last update: 23.01.2008
Fundamental Studies (2006)
The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific
Biglycan (bgn) is a small leucine-rich proteoglycan (SLRP) enriched in the extracellular matrix of skeletal tissues. While bgn is known to be involved in the growth and differentiation of osteoblast precursor c weiter...
Author: Wallace JM, Rajachar RM, Chen XD, Shi S, Allen MR, Bloomfield SA, Les CM, Robey PG, Young MF, Kohn DH
Source: Bone., 2006; 39(1): 106-16, PMID: 16527557
GID: 916; Last update: 23.01.2008
Fundamental Studies (2006)
Inflammation is a complex cellular and humoral response against trauma and infection, and its presence leads to destruction of tissue in humans. The mechanisms that initiate inflammatory diseases remain largely weiter...
Author: Abe K, Fuchs H, Lisse T, Hans W, Hrabé de Angelis M
Source: Mamm Genome., 2006; 17(9): 915-26, PMID: 16964445
GID: 917; Last update: 23.01.2008
Fundamental Studies (2006)
Strain-dependent differences in bone adaptive responses to loading among inbred mouse strains suggest that genetic background contributes significantly to adaptation to exercise. To explore the genetic regulati weiter...
Author: Kesavan C, Mohan S, Srivastava AK, Kapoor S, Wergedal JE, Yu H, Baylink DJ
Source: Bone., 2006; 39(3): 634-43, PMID: 16713414
GID: 919; Last update: 23.01.2008
Fundamental Studies (2006)
Increased expression of several osteoblastic proteases and MEPE (a bone matrix protein) occurs in X-linked hypophosphatemic rickets (hyp). This is associated with an increased release of a protease-resistant ME weiter...
Author: Rowe PS, Matsumoto N, Jo OD, Shih RN, Oconnor J, Roudier MP, Bain S, Liu S, Harrison J, Yanagawa N
Source: Bone., 2006; 39(4): 773-86, PMID: 16762607
GID: 920; Last update: 23.01.2008
Fundamental Studies (2006)
Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice
It has been hypothesized that activation of peroxisome-proliferator-activated receptor-gamma (PPARgamma) by thiazolidinedione drugs can increase adipogenesis at the expense of osteogenesis, leading to bone loss weiter...
Author: Li M, Pan LC, Simmons HA, Li Y, Healy DR, Robinson BS, Ke HZ, Brown TA
Source: Bone., 2006; 39(4): 796-806, PMID: 16759917
GID: 921; Last update: 23.01.2008
Fundamental Studies (2006)
Differential bone and muscle recovery following hindlimb unloading in skeletally mature male rats
This study was designed to track the recovery of bone and muscle properties after 28 days of hindlimb unloading (HU) in skeletally mature male rats in order to quantify the degree and timing of the expected mis weiter...
Author: Allen MR, Hogan HA, Bloomfield SA
Source: J Musculoskelet Neuronal Interact., 2006; 6(3): 217-25, PMID: 17142941
GID: 922; Last update: 23.01.2008
More information: Original Article
Fundamental Studies (2006)
Increased osteogenic response to exercise in metaphyseal versus diaphyseal cortical bone
Recent experimental data suggest that the anabolic response of bone to changes in physical activity and mechanical loading may vary among different skeletal elements, and even within different regions of the sa weiter...
Author: Hamrick MW, Skedros JG, Pennington C, McNeil PL
Source: J Musculoskelet Neuronal Interact., 2006; 6(3): 258-63, PMID: 17142947
GID: 923; Last update: 23.01.2008
More information: Original Article
Fundamental Studies (2006)
Effect of a single botulinum toxin injection on bone development in growing rabbits
Intramuscular injections with botulinum toxin A (BTX-A) lead to a rapid decrease in muscle mass and force, but the effect of this drug on bone development is unclear. In the present pilot study we evaluated the weiter...
Author: Rauch F, Hamdy R
Source: J Musculoskelet Neuronal Interact., 2006; 6(3): 264-8, PMID: 17142948
GID: 924; Last update: 23.01.2008
More information: Original Article
Fundamental Studies (2006)
Pregnancy-associated plasma protein (PAPP)-A, a protease for IGF binding protein (IGFBP)-2, -4, and -5, may enhance IGF action by increasing its bioavailability. Here we have determined the role and mechanism o weiter...
Author: Qin X, Wergedal JE, Rehage M, Tran K, Newton J, Lam P, Baylink DJ, Mohan S
Source: Endocrinology., 2006; 147(12): 5653-61, PMID: 16946002
GID: 925; Last update: 23.01.2008
Fundamental Studies (2003)
Effect of unilateral superior cervical ganglionectomy on mandibular bone in rats
OBJECTIVE: To assess the effect of local sympathectomy on mandibular bone during tooth eruption in rats. METHODS: The effect of a unilateral superior cervical ganglionectomy (Gx) on morphometry of ipsi- and con weiter...
Author: Ladizesky M, Lama MA, Roldán EJ, Cutrera RA, Boggio V, Giglio MJ, Cardinali DP
Source: Neuro Endocrinol Lett., 2003; 24(5): 314-20, PMID: 14647003
GID: 827; Last update: 22.01.2008
Fundamental Studies (2003)
To first test the possible effect of gender on the responsiveness of growing rat skeleton to mechanical loading, 5-week-old littermates of 25 male and 25 female rats were subjected to either free-cage activity weiter...
Author: Järvinen TL, Kannus P, Pajamäki I, Vuohelainen T, Tuukkanen J, Järvinen M, Sievänen H
Source: Bone., 2003; 32(6): 642-51, PMID: 12810171
GID: 828; Last update: 22.01.2008
Fundamental Studies (2002)
To determine the contributions of estrogen receptor (ER)alpha and ERbeta in bone growth and remodeling in male and female mice, we generated and analyzed full knockouts for each receptor, and a double ER knocko weiter...
Author: Sims NA, Dupont S, Krust A, Clement-Lacroix P, Minet D, Resche-Rigon M, Gaillard-Kelly M, Baron R
Source: Bone., 2002; 30(1): 18-25, PMID: 11792560
GID: 829; Last update: 22.01.2008
Fundamental Studies (2003)
Congenic mice reveal sex-specific genetic regulation of femoral structure and strength
Genetic linkage studies in C3H/HeJ (C3H) and C57BL/6J (B6) mice identified several chromosomal locations or quantitative trait loci (QTL) linked to femoral volumetric bone mineral density (vBMD). From QTL ident weiter...
Author: Turner CH, Sun Q, Schriefer J, Pitner N, Price R, Bouxsein ML, Rosen CJ, Donahue LR, Shultz KL, Beamer WG
Source: Calcif Tissue Int., 2003; 73(3): 297-303, PMID: 14667144
GID: 830; Last update: 22.01.2008
Fundamental Studies (2003)
Femoral neck response to exercise and subsequent deconditioning in young and adult rats
Aged bones have been considered to have reduced capacity to respond to changes in incident loading. By subjecting young and adult rats to increased loading and subsequent deconditioning, we observed quantitativ weiter...
Author: Järvinen TL, Pajamäki I, Sievänen H, Vuohelainen T, Tuukkanen J, Järvinen M, Kannus P
Source: J Bone Miner Res., 2003; 18(7): 1292-9, PMID: 12854840
GID: 831; Last update: 22.01.2008
Fundamental Studies (2001)
Torsional testing and peripheral quantitative computed tomography in rat humerus
Peripheral quantitative computed tomography (pQCT) is a noninvasive method mainly used to evaluate the densitometric and geometric properties of bone. In the present study, we evaluate the different variables p weiter...
Author: Lind PM, Lind L, Larsson S, Orberg J
Source: Bone., 2001; 29(3): 265-70, PMID: 11557371
GID: 832; Last update: 22.01.2008
Fundamental Studies (2000)
In previous studies we have described structural and functional changes in rat bone tissue caused by 3,3",4,4",5-pentachlorobiphenyl (PCB126). Some of the effects caused by PCB126 resemble those found in vitami weiter...
Author: Lind PM, Larsson S, Johansson S, Melhus H, Wikström M, Lindhe O, Orberg J
Source: Toxicology., 2000; 151(1-3): 11-23, PMID: 11074296
GID: 833; Last update: 22.01.2008
Fundamental Studies (2002)
Age-related changes in bone mineral density (BMD), cross-sectional area and strength strain index (SSI) of the long bones in the limbs and first lumbar vertebra of male Wistar rats were measured by a peripheral weiter...
Author: Iida H, Fukuda S
Source: J Vet Med Sci., 2002; 64(1): 29-34, PMID: 11853142
GID: 834; Last update: 22.01.2008
Fundamental Studies (2001)
This prospective 5-year follow-up study of 64 adult female racquet sports players and 27 controls assessed the changes in the playing-to-nonplaying arm bone mineral content (BMC) differences to answer three que weiter...
Author: Kontulainen S, Kannus P, Haapasalo H, Sievänen H, Pasanen M, Heinonen A, Oja P, Vuori I
Source: J Bone Miner Res., 2001; 16(2): 195-201, PMID: 11204418
GID: 835; Last update: 22.01.2008
Fundamental Studies (2003)
The present study was designed to determine the effects of glucocorticoid (GC) on bone turnover, minerals, structure, and bone mechanical properties in minipigs. Six 8-month-old Göttingen minipigs were subcuta weiter...
Author: Ikeda S, Morishita Y, Tsutsumi H, Ito M, Shiraishi A, Arita S, Akahoshi S, Narusawa K, Nakamura T
Source: Bone., 2003; 33(5): 779-87, PMID: 14623053
GID: 836; Last update: 22.01.2008
Fundamental Studies (2004)
The tumor necrosis factor family ligand, tumor necrosis factor-related activation-induced cytokine (TRANCE), and its receptors, receptor activator of nuclear factor-kappaB (RANK) and osteoprotegerin (OPG), are weiter...
Author: Cheng X, Kinosaki M, Takami M, Choi Y, Zhang H, Murali R
Source: J Biol Chem., 2004; 279(9): 8269-77, PMID: 14679212
GID: 837; Last update: 22.01.2008
Fundamental Studies (2003)
Biglycan deficiency interferes with ovariectomy-induced bone loss
Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OV weiter...
Author: Nielsen KL, Allen MR, Bloomfield SA, Andersen TL, Chen XD, Poulsen HS, Young MF, Heegaard AM
Source: J Bone Miner Res., 2003; 18(12): 2152-8, PMID: 14672350
GID: 838; Last update: 22.01.2008
Fundamental Studies (2003)
Precision and accuracy of DXA and pQCT for densitometry of the rat femur
Measurements of bone mineral density and bone mineral content are key data in the study of osteoporosis and pathologic skeletal disease. Dual-energy X-ray absorptiometry and peripheral quantitative computed tom weiter...
Author: Horton JA, Murray GM, Spadaro JA, Margulies BS, Allen MJ, Damron TA
Source: J Clin Densitom., 2003; 6(4): 381-90, PMID: 14716052
GID: 839; Last update: 22.01.2008
Fundamental Studies (2004)
Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice
Steroid receptor coactivator (SRC)-1 is an important nuclear receptor coactivator that enhances estrogen (E) action in many tissues, but its role in mediating E effects on bone is unknown. Thus, we assessed the weiter...
Author: Mödder UI, Sanyal A, Kearns AE, Sibonga JD, Nishihara E, Xu J, O"Malley BW, Ritman EL, Riggs BL, Spelsberg TC, Khosla S
Source: Endocrinology., 2004; 145(2): 913-21, PMID: 14563705
GID: 840; Last update: 22.01.2008
Fundamental Studies (2004)
To study the musculoskeletal effects of hypophysectomy (Hx) and a partial replacement treatment with recombinant human growth hormone (rhGH) in rats, we determined the stiffness (elastic modulus, E) and volumet weiter...
Author: Feldman S, Cointry GR, Leite Duarte ME, Sarrió L, Ferretti JL, Capozza RF
Source: Bone., 2004; 34(1): 203-15, PMID: 14751579
GID: 841; Last update: 22.01.2008
Fundamental Studies (2004)
The purpose of this study was to determine the long-term effects of lasofoxifene, a new selective estrogen receptor modulator, on bone mass, bone strength, and reproductive tissues in ovariectomized (OVX) rats. weiter...
Author: Ke HZ, Foley GL, Simmons HA, Shen V, Thompson DD
Source: Endocrinology., 2004; 145(4): 1996-2005, PMID: 14726439
GID: 842; Last update: 22.01.2008
Fundamental Studies (2004)
Glucocorticoids (GCs) exert potent, but poorly characterized, effects on the skeleton. The cellular activity of GCs is regulated at a prereceptor level by 11beta-hydroxysteroid dehydrogenases (11betaHSDs). The weiter...
Author: Justesen J, Mosekilde L, Holmes M, Stenderup K, Gasser J, Mullins JJ, Seckl JR, Kassem M
Source: Endocrinology., 2004; 145(4): 1916-25, PMID: 14715714
GID: 843; Last update: 22.01.2008
Fundamental Studies (2004)
Previous studies have associated activation of canonical Wnt signaling in osteoblasts with elevated bone formation. Here we report that deletion of the murine Wnt antagonist, secreted frizzled-related protein ( weiter...
Author: Bodine PV, Zhao W, Kharode YP, Bex FJ, Lambert AJ, Goad MB, Gaur T, Stein GS, Lian JB, Komm BS
Source: Mol Endocrinol., 2004; 18(5): 1222-37, PMID: 14976225
GID: 844; Last update: 22.01.2008
Fundamental Studies (2004)
Mutations in the fibroblast growth factor 23 gene, FGF23, cause autosomal dominant hypophosphatemic rickets (ADHR). The gene product, FGF-23, is produced by tumors from patients with oncogenic osteomalacia (OOM weiter...
Author: Larsson T, Marsell R, Schipani E, Ohlsson C, Ljunggren O, Tenenhouse HS, Jüppner H, Jonsson KB
Source: Endocrinology., 2004; 145(7): 3087-94, PMID: 14988389
GID: 845; Last update: 22.01.2008
Fundamental Studies (2004)
Prostaglandin E(2) (PGE(2)) is essential for fracture healing. Systemic administration of EP4 ligands such as PGE(2) and other synthetic EP4 agonists appears to transduce anabolic signals by binding to receptor weiter...
Author: Tanaka M, Sakai A, Uchida S, Tanaka S, Nagashima M, Katayama T, Yamaguchi K, Nakamura T
Source: Bone., 2004; 34(6): 940-8, PMID: 15193540
GID: 846; Last update: 22.01.2008
Fundamental Studies (2004)
Conditions of disuse in bed rest patients, as well as microgravity experienced by astronauts are accompanied by reduced mechanical loading, reduced calcium absorption, and lower serum levels of 1,25(OH)2D3 (1,2 weiter...
Author: Narayanan R, Allen MR, Gaddy D, Bloomfield SA, Smith CL, Weigel NL
Source: Bone., 2004; 35(1): 134-43, PMID: 15207749
GID: 847; Last update: 22.01.2008
Fundamental Studies (2004)
Mechanical tests of bone provide valuable information about material and structural properties important for understanding bone pathology in both clinical and research settings, but no previous studies have pro weiter...
Author: Martin DE, Severns AE, Kabo JM
Source: J Biomech., 2004; 37(8): 1289-93, PMID: 15212935
GID: 848; Last update: 22.01.2008
Fundamental Studies (2003)
This study was designed to determine the effects of 28 days of hindlimb unloading (HU) on the mature female rat skeleton. In vivo proximal tibia bone mineral density and geometry of HU and cage control (CC) rat weiter...
Author: Allen MR, Bloomfield SA
Source: J Appl Physiol., 2003; 94(2): 642-50, PMID: 12391029
GID: 849; Last update: 22.01.2008
Fundamental Studies (2004)
The b and c variants of fibroblast growth factor receptor 2 (FGFR2) differ in sequence, binding specificity, and localization. Fgfr2b, expressed in epithelia, is required for limb outgrowth and branching morpho weiter...
Author: Eswarakumar VP, Horowitz MC, Locklin R, Morriss-Kay GM, Lonai P
Source: Proc Natl Acad Sci U S A., 2004; 101(34): 12555-60, PMID: 15316116
GID: 850; Last update: 22.01.2008
Fundamental Studies (1999)
Ovariectomy in young, growing rodents results in decreased trabecular bone mineral density (BMD) and increased radial growth of the cortical bone. Both of these effects are reversed by treatment with estrogen. weiter...
Author: Windahl SH, Vidal O, Andersson G, Gustafsson JA, Ohlsson C
Source: J Clin Invest., 1999; 104(7): 895-901, PMID: 10510330
GID: 851; Last update: 22.01.2008
Fundamental Studies (2004)
BACKGROUND: Bone loss in osteoporosis is caused by an imbalance between resorption and formation on endosteal surfaces of trabecular and cortical bone. We investigated the feasibility of increasing endosteal bo weiter...
Author: Zhang XS, Linkhart TA, Chen ST, Peng H, Wergedal JE, Guttierez GG, Sheng MH, Lau KH, Baylink DJ
Source: J Gene Med., 2004; 6(1): 4-15, PMID: 14716672
GID: 852; Last update: 22.01.2008
Fundamental Studies (2002)
Skeletal effects are described for near-lifetime treatment of young, female rats with recombinant human PTH (1-34) (PTH). Rats (5-8 wk of age) were administered 0, 5, 30, or 75 microg/kg x d sc PTH for up to 2 weiter...
Author: Sato M, Vahle J, Schmidt A, Westmore M, Smith S, Rowley E, Ma LY
Source: Endocrinology., 2002; 143(9): 3230-42, PMID: 12193534
GID: 853; Last update: 22.01.2008
Fundamental Studies (2004)
Reproductive disorders have been found in pesticide-exposed alligators living in Lake Apopka, Florida (USA). These disorders have been hypothesized to be caused by exposure to endocrine- disruptive estrogen-lik weiter...
Author: Lind PM, Milnes MR, Lundberg R, Bermudez D, Orberg JA, Guillette LJ Jr
Source: Environ Health Perspect., 2004; 112(3): 359-62, PMID: 14998753
GID: 854; Last update: 22.01.2008
Fundamental Studies (2003)
Bone mineral density in male Baltic grey seal (Halichoerus grypus)
Bone mineral density (mg cm(-3)) was studied in male Baltic grey seals (4-23 years of age) by noninvasive computed tomography (pQCT). The material was grouped according to year of collection. Group A: 1850-1955 weiter...
Author: Lind PM, Bergman A, Olsson M, Orberg J
Source: Ambio., 2003; 32(6): 385-8, PMID: 14627366
GID: 855; Last update: 22.01.2008
Fundamental Studies (2005)
IGF-binding protein-5 (IGFBP-5) is abundant in serum and bone during normal skeletal development, but levels decrease in osteoporosis. Studies have shown that IGFBP-5 stimulates markers of bone formation by pot weiter...
Author: Salih DA, Mohan S, Kasukawa Y, Tripathi G, Lovett FA, Anderson NF, Carter EJ, Wergedal JE, Baylink DJ, Pell JM
Source: Endocrinology., 2005; 146(2): 931-40, PMID: 15550514
GID: 856; Last update: 22.01.2008
Fundamental Studies (2004)
Here, we present evidence that Lrp6, a coreceptor for Wnt ligands, is required for the normal formation of somites and bones. By positional cloning, we demonstrate that a novel spontaneous mutation ringelschwan weiter...
Author: Kokubu C, Heinzmann U, Kokubu T, Sakai N, Kubota T, Kawai M, Wahl MB, Galceran J, Grosschedl R, Ozono K, Imai K
Source: Development., 2004; 131(21): 5469-80, PMID: 15469977
GID: 857; Last update: 22.01.2008
Fundamental Studies (2004)
Calbindin (CaBP)-D28k and CaBP-D9k are cytosolic vitamin D-dependent calcium-binding proteins long thought to play an important role in transepithelial calcium transport. However, recent genetic studies suggest weiter...
Author: Zheng W, Xie Y, Li G, Kong J, Feng JQ, Li YC
Source: J Biol Chem., 2004; 279(50): 52406-13, PMID: 15456794
GID: 858; Last update: 22.01.2008
Fundamental Studies (2004)
A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
Caspase-3 is a critical enzyme for apoptosis and cell survival. Here we report delayed ossification and decreased bone mineral density in caspase-3-deficient (Casp3(-/-) and Casp3(+/-)) mice due to an attenuate weiter...
Author: Miura M, Chen XD, Allen MR, Bi Y, Gronthos S, Seo BM, Lakhani S, Flavell RA, Feng XH, Robey PG, Young M, Shi S
Source: J Clin Invest., 2004; 114(12): 1704-13, PMID: 15599395
GID: 859; Last update: 22.01.2008
Fundamental Studies (2004)
Because SBM may contribute to cartilage breakdown in OA, experimental OA was induced in dogs by transecting the anterior cruciate ligament of the knee and treating with either CT or a placebo. CT significantly weiter...
Author: Behets C, Williams JM, Chappard D, Devogelaer JP, Manicourt DH
Source: J Bone Miner Res., 2004; 19(11): 1821-6, PMID: 15476582
GID: 860; Last update: 22.01.2008
Fundamental Studies (2004)
Adaptations to free-fall impact are different in the shafts and bone ends of rat forelimbs
Impact exercise can have beneficial effects on the growing skeleton. To understand what changes it promotes in the shafts and ends of weight-bearing bones, we measured the effects of impact from repetitive free weiter...
Author: Welch JM, Weaver CM, Turner CH
Source: J Appl Physiol., 2004; 97(5): 1859-65, PMID: 15258128
GID: 861; Last update: 22.01.2008
Fundamental Studies (2004)
Both ER and AR activation regulates trabecular bone mass. We show that combined estrogen and androgen treatment results in additive protection of trabecular bone in OVX rats. This may in part be attributable to weiter...
Author: Tivesten A, Movérare-Skrtic S, Chagin A, Venken K, Salmon P, Vanderschueren D, Sävendahl L, Holmäng A, Ohlsson C
Source: J Bone Miner Res., 2004; 19(11): 1833-9, PMID: 15476584
GID: 862; Last update: 22.01.2008
Fundamental Studies (2004)
We examined the long-term sensitivity of uterus and bone to low-dose 17beta-estradiol in a 4-month experiment in OVX rats and found that a dose of estradiol that fully protected against uterine atrophy did not weiter...
Author: Erben RG, Brunner KS, Breig B
Source: J Bone Miner Res., 2004; 19(11): 1827-32, PMID: 15476583
GID: 863; Last update: 22.01.2008
Fundamental Studies (2004)
Thiazolidinediones are insulin-sensitizing agents and in clinical use for the treatment of type II diabetes. Under specific experimental conditions, these molecules induce adipogenic differentiation of mesenchy weiter...
Author: Sottile V, Seuwen K, Kneissel M
Source: Calcif Tissue Int., 2004; 75(4): 329-37, PMID: 15549648
GID: 865; Last update: 22.01.2008
Fundamental Studies (2004)
Site-specific effects of cerivastatin on bone in male Sprague-Dawley rats
It is well established that age-related bone loss occurs in men and male SD rats. This study was designed to determine whether cerivastatin will prevent age-related bone loss in male Sprague-Dawley (SD) rats. P weiter...
Author: Banu J, Kalu DN
Source: Bone., 2004; 34(3): 432-42, PMID: 15003791
GID: 866; Last update: 22.01.2008
Fundamental Studies (2004)
OBJECTIVE: To compare bone mineral measurements obtained by use of dual-energy x-ray absorptiometry (DEXA), peripheral quantitative computed tomography (pQCT), and chemical-physical analyses and determine effec weiter...
Author: Schneider S, Breit SM, Grampp S, Künzel WW, Liesegang A, Mayrhofer E, Zentek J
Source: Am J Vet Res., 2004; 65(7): 891-900, PMID: 15281646
GID: 867; Last update: 22.01.2008
Fundamental Studies (2004)
Belamcanda chinensis (BC) belongs to the family of iridaceae and the isoflavone tectorigenin has been isolated from the rhizome of this plant. Whether this isoflavone has estrogenic, possibly selective estrogen weiter...
Author: Seidlová-Wuttke D, Hesse O, Jarry H, Rimoldi G, Thelen P, Christoffel V, Wuttke W
Source: Phytomedicine., 2004; 11(5): 392-403, PMID: 15330494
GID: 868; Last update: 22.01.2008
Fundamental Studies (2004)
Effects of grape seed proanthocyanidins extract on rat mandibular condyle
We investigated the effects of grape seed proanthocyanidins extract (GSPE) on bone formation by examining total and cortical bone mass, density, architecture, and strength non-invasively using mandibular condyl weiter...
Author: Kojima K, Maki K, Tofani I, Kamitani Y, Kimura M
Source: J Musculoskelet Neuronal Interact., 2004; 4(3): 301-7, PMID: 15615498
GID: 869; Last update: 22.01.2008
More information: Original Article
Fundamental Studies (2004)
To evaluate the biological effects of vitamin K2 (menatetrenone, MK-4) on ovariectomy (OVX)-induced bone loss, we have examined histological alterations of femoral metaphyses of sham-operated (sham group), ovar weiter...
Author: Asawa Y, Amizuka N, Hara K, Kobayashi M, Aita M, Li M, Kenmotsu S, Oda K, Akiyama Y, Ozawa H
Source: Bone., 2004; 35(4): 870-80, PMID: 15454094
GID: 870; Last update: 22.01.2008
Fundamental Studies (2004)
Cyclic loading induces fatigue in bone and initiates a complex, functionally adaptive response. We investigated the effect of a single period of fatigue on the histologic structure and biomechanical properties weiter...
Author: Colopy SA, Benz-Dean J, Barrett JG, Sample SJ, Lu Y, Danova NA, Kalscheur VL, Vanderby R Jr, Markel MD, Muir P
Source: Bone., 2004; 35(4): 881-91, PMID: 15454095
GID: 871; Last update: 22.01.2008
Fundamental Studies (2005)
Retinoid-induced bone thinning is caused by subperiosteal osteoclast activity in adult rodents
Excess of Vitamin A (retinol) and related compounds (retinoids) induces bone fragility and is associated with increased hip fracture incidence in humans. Yet, their impact on the adult skeleton has been studied weiter...
Author: Kneissel M, Studer A, Cortesi R, Susa M
Source: Bone., 2005; 36(2): 202-14, PMID: 15780946
GID: 872; Last update: 22.01.2008
Fundamental Studies (2005)
Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice
Bone anabolic action of PTH has been suggested to be mediated by induction of IGF-I in osteoblasts; however, little is known about the molecular mechanism by which IGF-I leads to bone formation under the PTH st weiter...
Author: Yamaguchi M, Ogata N, Shinoda Y, Akune T, Kamekura S, Terauchi Y, Kadowaki T, Hoshi K, Chung UI, Nakamura K, Kawaguchi H
Source: Endocrinology., 2005; 146(6): 2620-8, PMID: 15718274
GID: 873; Last update: 22.01.2008
Fundamental Studies (2004)
In this study, we examined changes in bone parameters and bone strength in rats fed low-Mg diets (experiment 1) and the effects of vitamin K2 (MK-4, experiment 3) and alendronate (ALN, experiment 2) in this mod weiter...
Author: Kobayashi M, Hara K, Akiyama Y
Source: Bone., 2004; 35(5): 1136-43, PMID: 15542039
GID: 874; Last update: 22.01.2008
Fundamental Studies (2004)
The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis
Recently, the involvement of immune responses in metabolic bone disease and/or local bone destruction has received much attention. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a member of the immunoglo weiter...
Author: Nagahama K, Aoki K, Nonaka K, Saito H, Takahashi M, Varghese BJ, Shimokawa H, Azuma M, Ohya K, Ohyama K
Source: Bone., 2004; 35(5): 1059-68, PMID: 15542030
GID: 875; Last update: 22.01.2008
Fundamental Studies (2004)
The proliferation inhibitor of the macrolide class, everolimus, is a drug shown to be effective in the prevention of organ transplant rejection and to have a potential in the treatment of rheumatoid arthritis a weiter...
Author: Kneissel M, Luong-Nguyen NH, Baptist M, Cortesi R, Zumstein-Mecker S, Kossida S, O"Reilly T, Lane H, Susa M
Source: Bone., 2004; 35(5): 1144-56, PMID: 15542040
GID: 876; Last update: 22.01.2008
Fundamental Studies (2003)
La mise au point d´un petit scanner de´die´au membre de cheval, applications pratiques
Author: F Desbrosse, S Mosseri, R Perrin, MT Launois
Source: Bull Soc Vet Prat de France, 2003; 87: 126-137
GID: 720; Last update: 15.01.2008
Fundamental Studies (2002)
Bone loss and long-term persistence of osteoporosis with increased fracture risk are common after liver transplantation. It is unknown whether transplantation-induced disruption of hepatic nerves, serving numer weiter...
Author: Kissler HJ, Erben RG, Hennig R, Gepp H, Stahr K, Hohenberger W, Schwille PO
Source: Calcif Tissue Int., 2002; 71(2): 193-202, PMID: 12200652
GID: 706; Last update: 15.01.2008
Fundamental Studies (2002)
Subclinical hypervitaminosis A causes fragile bones in rats
Excessive intake of vitamin A has been associated with an increased risk of hip fracture in humans. This finding has raised the question of whether long-term intake of relatively moderate doses ("subclinical" h weiter...
Author: Johansson S, Lind PM, Hakansson H, Oxlund H, Orberg J, Melhus H
Source: Bone., 2002; 31(6): 685-9, PMID: 12531562
GID: 707; Last update: 15.01.2008
Fundamental Studies (2002)
The molecular and cellular mechanism of estrogen action in skeletal tissue remains unclear. The purpose of this study was to understand the role of estrogen receptor-beta, (ERbeta) on cortical and cancellous bo weiter...
Author: Ke HZ, Brown TA, Qi H, Crawford DT, Simmons HA, Petersen DN, Allen MR, McNeish JD, Thompson DD
Source: J Musculoskelet Neuronal Interact., 2002; 2(5): 479-88, PMID: 15758417
GID: 708; Last update: 15.01.2008
More information: Original Article
Fundamental Studies (2002)
Vitamin K(2) (K(2), menatetrenone) has been reported to enhance bone formation and inhibit bone resorption in vitro. However, there is no evidence that K(2) enhances bone formation in vivo. The aim of this stud weiter...
Author: Hara K, Kobayashi M, Akiyama Y
Source: Bone., 2002; 31(5): 575-81, PMID: 12477571
GID: 709; Last update: 15.01.2008
Fundamental Studies (2002)
Vitamin D (D) deficiency during human pregnancy appears to disturb fetal growth and mineralization, but fetal development is normal in D-deficient rats and vitamin D receptor gene-ablated mice. We used the guin weiter...
Author: Rummens K, van Bree R, Van Herck E, Zaman Z, Bouillon R, Van Assche FA, Verhaeghe J
Source: Calcif Tissue Int., 2002; 71(4): 364-75, PMID: 12196905
GID: 710; Last update: 15.01.2008
Fundamental Studies (2003)
The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo
The specific biological function of the cell surface or membrane-bound isoform of colony-stimulating factor-1 (mCSF-1) is not well understood. To help define the role of this isoform in bone, we developed a tra weiter...
Author: Yao GQ, Wu JJ, Sun BH, Troiano N, Mitnick MA, Insogna K
Source: Endocrinology., 2003; 144(8): 3677-82, PMID: 12865350
GID: 711; Last update: 15.01.2008
Fundamental Studies (2002)
Morphological and biomechanical features of the mandible are negatively affected by protein-energy malnutrition, whose effects are apparently dependent on the time of life of application. The aim here was to in weiter...
Author: Alippi RM, Meta MD, Olivera MI, Bozzini C, Schneider P, Meta IF, Bozzini CE
Source: Arch Oral Biol., 2002; 47(1): 47-53, PMID: 11743931
GID: 712; Last update: 15.01.2008
Fundamental Studies (2003)
The P2X7 nucleotide receptor is an ATP-gated ion channel expressed widely in cells of hematopoietic origin. Our purpose was to explore the involvement of the P2X7 receptor in bone development and remodeling by weiter...
Author: Ke HZ, Qi H, Weidema AF, Zhang Q, Panupinthu N, Crawford DT, Grasser WA, Paralkar VM, Li M, Audoly LP, Gabel CA, Jee WS, Dixon SJ, Sims SM, Thompson DD
Source: Mol Endocrinol., 2003; 17(7): 1356-67, PMID: 12677010
GID: 713; Last update: 15.01.2008
Fundamental Studies (2003)
Effects of increased muscle mass on bone in male mice overexpressing IGF-I in skeletal muscles
It has been hypothesized that increase in muscle mass increases the strain on bone resulting in increase in bone mass. The aim of the present study was to determine the effects of increased muscle mass on bone. weiter...
Author: Banu J, Wang L, Kalu DN
Source: Calcif Tissue Int., 2003; 73(2): 196-201, PMID: 14565602
GID: 714; Last update: 15.01.2008
Fundamental Studies (2003)
We describe here the activity of a novel selective estrogen receptor modulator, SP500263. When given to adult ovariectomized (OVX) rats for 28 days at doses of 0.3, 1, or 3 mg/kg/day, we found that SP500263 par weiter...
Author: Sutherland MK, Brady H, Gayo-Fung LM, Leisten J, Lipps SG, McKie JA, O"Leary E, Patnaik N, Anderson DW, Bhagwat SS, Stein B
Source: Calcif Tissue Int., 2003; 72(6): 710-6, PMID: 14563000
GID: 715; Last update: 15.01.2008
Fundamental Studies (2003)
We previously found that the magnitude of skeletal deficits caused by GH deficiency varied during different growth periods. To test the hypothesis that the sensitivity to GH is growth period dependent, we treat weiter...
Author: Kasukawa Y, Baylink DJ, Guo R, Mohan S
Source: Endocrinology., 2003; 144(9): 3950-7, PMID: 12933669
GID: 716; Last update: 15.01.2008
Fundamental Studies (2002)
Bisphosphonate treatment is beneficial against symptoms of metastatic bone disease, although less is known about the effect of preventative treatment schedules. We investigated the effect of various treatment r weiter...
Author: Kurth AA, Kim SZ, Sedlmeyer I, Bauss F, Shea M
Source: Bone., 2002; 30(1): 300-6, PMID: 11792601
GID: 717; Last update: 15.01.2008
Fundamental Studies (2002)
Age-related changes in bone mineral content and density in intact male F344 rats
This study was undertaken to determine whether age-related bone loss occurs in intact male F344 rats. Bone loss was assessed in male F344 rats aged 3 to 27 months by scanning different bones using peripheral qu weiter...
Author: Banu J, Wang L, Kalu DN
Source: Bone., 2002; 30(1): 125-30, PMID: 11792574
GID: 718; Last update: 15.01.2008
Fundamental Studies (2003)
Although the role of estradiol in maintaining bone mass is well established, the relative contributions of the estradiol receptors ERalpha and ERbeta and of the androgen receptor (AR) remain controversial. To d weiter...
Author: Sims NA, Clément-Lacroix P, Minet D, Fraslon-Vanhulle C, Gaillard-Kelly M, Resche-Rigon M, Baron R
Source: J Clin Invest., 2003; 111(9): 1319-27, PMID: 12727923
GID: 719; Last update: 15.01.2008
Fundamental Studies (2003)
Large amounts of calcium are transferred to offspring by milk. This demand results in negative calcium balance in lactating mothers and is associated with rapid bone loss. The mechanisms of bone loss during lac weiter...
Author: VanHouten JN, Dann P, Stewart AF, Watson CJ, Pollak M, Karaplis AC, Wysolmerski JJ
Source: J Clin Invest., 2003; 112(9): 1429-36, PMID: 14597768
GID: 721; Last update: 15.01.2008
Fundamental Studies (2003)
Androgens may regulate the male skeleton either directly by stimulation of the androgen receptor (AR) or indirectly by aromatization of androgens into estrogens and, thereafter, by stimulation of the estrogen r weiter...
Author: Movérare S, Venken K, Eriksson AL, Andersson N, Skrtic S, Wergedal J, Mohan S, Salmon P, Bouillon R, Gustafsson JA, Vanderschueren D, Ohlsson C
Source: Proc Natl Acad Sci U S A., 2003; 100(23): 13573-8, PMID: 14573701
GID: 722; Last update: 15.01.2008
Fundamental Studies (2003)
Estrogen and bone--a reproductive and locomotive perspective
The primary function of the skeleton is locomotion, and the primary function of estrogen is reproduction. When the skeleton is considered within this locomotive context, the onset of estrogen secretion at puber weiter...
Author: Järvinen TL, Kannus P, Sievänen H
Source: J Bone Miner Res., 2003; 18(11): 1921-31, PMID: 14606503
GID: 723; Last update: 15.01.2008
Fundamental Studies (2003)
pQCT provides better prediction of canine femur breaking load than does DXA
Our study was designed to examine the validity of dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) measurements as predictors of whole bone breaking strength in beag weiter...
Author: Moisio KC, Podolskaya G, Barnhart B, Berzins A, Sumner DR
Source: J Musculoskelet Neuronal Interact., 2003; 3(3): 240-5, PMID: 15758347
GID: 725; Last update: 15.01.2008
More information: Original Article
Fundamental Studies (2001)
Effects of high-frequency, low-magnitude mechanical stimulus on bone healing
Recent studies have shown osteogenic effects of high-frequency mechanical stimuli. The purpose of this study was whether externally applied, high-frequency, low-magnitude interfragmentary movements affect the p weiter...
Author: Wolf S, Augat P, Eckert-Hübner K, Laule A, Krischak GD, Claes LE
Source: Clin Orthop Relat Res., 2001; (385): 192-8, PMID: 11302314
GID: 677; Last update: 10.01.2008
Fundamental Studies (2002)
Bone mineral content and density in the humerus of adult myostatin-deficient mice
Myostatin (GDF-8), a member of the transforming growth factor-b superfamily of secreted growth and differentiation factors, is a negative regulator of skeletal muscle growth. We investigated the effects of incr weiter...
Author: Hamrick MW, McPherron AC, Lovejoy CO
Source: Calcif Tissue Int., 2002; 71(1): 63-8, PMID: 12060865
GID: 678; Last update: 10.01.2008
Fundamental Studies (2002)
Both men and women lose bone at a late age (aging bone loss). The aim of this study was to determine whether cerivastatin and parathyroid hormone (PTH) can prevent aging bone loss in men. Bone loss in aged male weiter...
Author: Banu J, Kalu DN
Source: Bone., 2002; 31(1): 173-9, PMID: 12110431
GID: 679; Last update: 10.01.2008
Fundamental Studies (2001)
The recent development of different genetically modified mice with potentially interesting bone phenotypes has increased the demand for effective non-invasive methods to evaluate effects on bone of mice during weiter...
Author: Andersson N, Lindberg MK, Ohlsson C, Andersson K, Ryberg B
Source: J Endocrinol., 2001; 170(3): 529-37, PMID: 11524233
GID: 680; Last update: 10.01.2008
Fundamental Studies (2002)
Site- and compartment-specific changes in bone with hindlimb unloading in mature adult rats
The purpose of this study was to examine site- and compartment-specific changes in bone induced by hindlimb unloading (HU) in the mature adult male rat (6 months old). Tibiae, femora, and humeri were removed af weiter...
Author: Bloomfield SA, Allen MR, Hogan HA, Delp MD
Source: Bone., 2002; 31(1): 149-57, PMID: 12110428
GID: 681; Last update: 10.01.2008
Fundamental Studies (2001)
In vivo studies have shown T cells to be central to the mechanism by which estrogen deficiency induces bone loss, but the mechanism involved remains, in part, undefined. In vitro, T cells from ovariectomized mi weiter...
Author: Roggia C, Gao Y, Cenci S, Weitzmann MN, Toraldo G, Isaia G, Pacifici R
Source: Proc Natl Acad Sci U S A., 2001; 98(24): 13960-5, PMID: 11717453
GID: 682; Last update: 10.01.2008
Fundamental Studies (2002)
A time course of bone response to jump exercise in C57BL/6J mice
Exercise, by way of mechanical loading, provides a physiological stimulus to which bone tissue adapts by increased bone formation. The mechanical stimulus due to physical activity depends on both the magnitude weiter...
Author: Umemura Y, Baylink DJ, Wergedal JE, Mohan S, Srivastava AK
Source: J Bone Miner Metab., 2002; 20(4): 209-15, PMID: 12115066
GID: 683; Last update: 10.01.2008
Fundamental Studies (2002)
Departing from the premise that it is the large-amplitude signals inherent to intense functional activity that define bone morphology, we propose that it is the far lower magnitude, high-frequency mechanical si weiter...
Author: Rubin C, Turner AS, Mallinckrodt C, Jerome C, McLeod K, Bain S
Source: Bone., 2002; 30(3): 445-52, PMID: 11882457
GID: 684; Last update: 10.01.2008
Fundamental Studies (2001)
Identification of bone selective vitamin D analogues would provide an interesting substance class for the treatment of osteoporosis. The synthetic prodrug 1alpha-hydroxyvitamin D2 [1alpha(OH)D2] has been shown weiter...
Author: Weber K, Goldberg M, Stangassinger M, Erben RG
Source: J Bone Miner Res., 2001; 16(4): 639-51, PMID: 11315991
GID: 685; Last update: 10.01.2008
Fundamental Studies (2002)
Insulin-like growth factor-binding protein-2 (IGFBP-2) has been suggested to be a negative regulator of bone growth and maintenance. The objective of this study was to characterize the effect of elevated IGFBP- weiter...
Author: Eckstein F, Pavicic T, Nedbal S, Schmidt C, Wehr U, Rambeck W, Wolf E, Hoeflich A
Source: Anat Embryol (Berl)., 2002; 206(1-2): 139-48, PMID: 12478375
GID: 686; Last update: 10.01.2008
Fundamental Studies (2003)
Rodent model for investigating the effects of estrogen on bone and muscle relationship during growth
It has been reported that in humans from about 11-12 years of age, bone mass begins to increase faster in girls than in boys with the same muscle mass, and by 14-15 years of age, bone mass per unit mass of musc weiter...
Author: Wang L, McMahan CA, Banu J, Okafor MC, Kalu DN
Source: Calcif Tissue Int., 2003; 72(2): 151-5, PMID: 12469248
GID: 687; Last update: 10.01.2008
Fundamental Studies (2001)
Thyroid hormone governs a diverse repertoire of physiological functions through receptors encoded in the receptor genes alpha and beta, which each generate variant proteins. In mammals, the alpha gene generates weiter...
Author: Saltó C, Kindblom JM, Johansson C, Wang Z, Gullberg H, Nordström K, Mansén A, Ohlsson C, Thorén P, Forrest D, Vennström B
Source: Mol Endocrinol., 2001; 15(12): 2115-28, PMID: 11731613
GID: 688; Last update: 10.01.2008
Fundamental Studies (2001)
Evidence that anabolic effects of PTH on bone require IGF-I in growing mice
Although it has been established that PTH exerts potent anabolic effects on bone in animals and humans, the mechanism of PTH action on bone remains controversial. Based on the previous findings that PTH treatme weiter...
Author: Miyakoshi N, Kasukawa Y, Linkhart TA, Baylink DJ, Mohan S
Source: Endocrinology., 2001; 142(10): 4349-56, PMID: 11564695
GID: 689; Last update: 10.01.2008
Fundamental Studies (2003)
RATIONALE AND OBJECTIVE: To assess the utility of dual energy x-ray absorptiometry (DEXA) and peripheral quantitative computed tomography (pQCT) in detecting trabecular and cortical bone changes in diabetes as weiter...
Author: Ahmad T, Ohlsson C, Ostenson CG, Kreicbergs A
Source: Invest Radiol., 2003; 38(3): 171-6, PMID: 12595798
GID: 690; Last update: 10.01.2008
Fundamental Studies (2003)
Anesthetized Sprague-Dawley weanling rats were scanned for bone mineral density (BMD) values after 7 days of treatment to determine whether resorption/growth at the proximal tibia can be quantified by periphera weiter...
Author: McHugh NA, Vercesi HM, Egan RW, Hey JA
Source: Am J Physiol Endocrinol Metab., 2003; 284(1): E70-5, PMID: 12388153
GID: 691; Last update: 10.01.2008
Fundamental Studies (2003)
Common herbs, essential oils, and monoterpenes potently modulate bone metabolism
During our survey of herbs looking for activity on bone metabolism, we found that the dried leaves of sage strongly inhibit bone resorption. Therefore, we investigated several common herbs rich in essential oil weiter...
Author: Mühlbauer RC, Lozano A, Palacio S, Reinli A, Felix R
Source: Bone., 2003; 32(4): 372-80, PMID: 12689680
GID: 692; Last update: 10.01.2008
Fundamental Studies (2002)
The runt family transcription factor core-binding factor alpha1 (Cbfa1) is essential for bone formation during development. Surprisingly, transgenic mice overexpressing Cbfa1 under the control of the 2.3-kb col weiter...
Author: Geoffroy V, Kneissel M, Fournier B, Boyde A, Matthias P
Source: Mol Cell Biol., 2002; 22(17): 6222-33, PMID: 12167715
GID: 693; Last update: 10.01.2008
Fundamental Studies (2002)
Mouse genetic model for bone strength and size phenotypes: NZB/B1NJ and RF/J inbred strains
The relationships of bone size, bone strength, and bone formation were investigated in two strains of mice, NZB/B1NJ and RF/J. Measurement of the femur midshaft size by peripheral quantitative computed tomograp weiter...
Author: Wergedal JE, Sheng MH, Ackert-Bicknell CL, Beamer WG, Baylink DJ
Source: Bone., 2002; 31(6): 670-4, PMID: 12531560
GID: 694; Last update: 10.01.2008
Fundamental Studies (2002)
Our knowledge of the developmental changes in the concentration of serum and bone osteocalcin (OC) is limited. To investigate the interrelationship between skeletal and circulatory OC during acquisition of peak weiter...
Author: Li X, Srivastava AK, Gu W, Masinde G, Mohan S, Baylink DJ
Source: Calcif Tissue Int., 2002; 71(5): 416-20, PMID: 12172650
GID: 695; Last update: 10.01.2008
Fundamental Studies (2002)
Bone mineral density variation is a highly heritable trait and is the best predictor of skeletal fragility. Total skeletal density was determined by PIXIMUS, and femur density was determined by pQCT. The data w weiter...
Author: Masinde GL, Li X, Gu W, Wergedal J, Mohan S, Baylink DJ
Source: Calcif Tissue Int., 2002; 71(5): 421-8, PMID: 12202954
GID: 696; Last update: 10.01.2008
Fundamental Studies (2001)
Previous studies have demonstrated that growth hormone (GH) has a marked anabolic effect on cortical bone and parathyroid hormone (PTH) has been shown to increase cancellous bone and cortical bone markedly in o weiter...
Author: Wang L, Orhii PB, Banu J, Kalu DN
Source: Mech Ageing Dev., 2001; 122(1): 89-104, PMID: 11163626
GID: 519; Last update: 12.12.2007
Fundamental Studies (2001)
Bone strength is an important clinical endpoint of osteoporosis research. The evaluation of the relative importance of bone and muscle components to bone strength has widespread implications for the understandi weiter...
Author: Li X, Mohan S, Gu W, Wergedal J, Baylink DJ
Source: Calcif Tissue Int., 2001; 68(6): 365-9, PMID: 11685425
GID: 520; Last update: 12.12.2007
Fundamental Studies (2001)
Levormeloxifene, a nonsteroidal selective estrogen receptor modulator (SERM), has been evaluated for its effects on bone in cynomolgus monkeys (Macaca fascicularis). Adult female monkeys were imported from Indo weiter...
Author: Hotchkiss CE, Stavisky R, Nowak J, Brommage R, Lees CJ, Kaplan J
Source: Bone., 2001; 29(1): 7-15, PMID: 11472885
GID: 521; Last update: 12.12.2007
Fundamental Studies (2001)
We investigated the effects of ovariectomy (ovx) and estrogen replacement therapy (ERT) on bone mineral density (BMD) and arthritis severity in rats with collagen-induced arthritis (CIA). Seven-month-old female weiter...
Author: Yamasaki D, Enokida M, Okano T, Hagino H, Teshima R
Source: Bone., 2001; 28(6): 634-40, PMID: 11425652
GID: 522; Last update: 12.12.2007
Fundamental Studies (2001)
The influence of recombinant human insulin-like growth factor-I (rhIGF-I), its binding protein-5 (IGFBP-5) or their equimolar complexes on calvarial osteogenesis was investigated by quantitative radiography and weiter...
Author: Bauss F, Lang K, Dony C, Kling L
Source: Growth Horm IGF Res., 2001; 11(1): 1-9, PMID: 11437468
GID: 523; Last update: 12.12.2007
Fundamental Studies (2001)
Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-alpha knockout mice
To examine the role of the estrogen receptor-alpha (ERalpha) during male skeletal development, bone density and structure of aged ERalphaKO mice and wild-type (WT) littermates were analyzed and skeletal changes weiter...
Author: Vandenput L, Ederveen AG, Erben RG, Stahr K, Swinnen JV, Van Herck E, Verstuyf A, Boonen S, Bouillon R, Vanderschueren D
Source: Biochem Biophys Res Commun., 2001; 285(1): 70-6, PMID: 11437374
GID: 524; Last update: 12.12.2007
Fundamental Studies (2000)
OBJECTIVE: Pathological processes in bone can lead to fatal health consequences. Therefore, it is important to study factors that possibly influence the activity of bone cells. The mast cell is a normal compone weiter...
Author: Cindik ED, Maurer M, Hannan MK, Müller R, Hayes WC, Hovy L, Kurth AA
Source: Technol Health Care., 2000; 8(5): 267-75, PMID: 11204172
GID: 525; Last update: 12.12.2007
Fundamental Studies (2001)
Effect of nickel-titanium shape memory metal alloy on bone formation
The aim of this study was to determine the biocompatibility of NiTi alloy on bone formation in vivo. For this purpose we used ectopic bone formation assay which goes through all the events of bone formation and weiter...
Author: Kapanen A, Ryhänen J, Danilov A, Tuukkanen J
Source: Biomaterials., 2001; 22(18): 2475-80, PMID: 11516078
GID: 526; Last update: 12.12.2007
Fundamental Studies (1998)
As part of a long-term safety study the bisphosphonate ibandronate was investigated for its effects on bone quality in lumbar vertebrae in rats. Bone area, bone density and mechanical properties were assessed b weiter...
Author: Lalla S, Hothorn LA, Haag N, Bader R, Bauss F
Source: Osteoporos Int., 1998; 8(2): 97-103, PMID: 9666930
GID: 527; Last update: 12.12.2007
Fundamental Studies (2001)
Osteopenia develops in experimental animals following surgical removal of the ovaries (ovariectomy. Ovx) or the stomach (gastrectomy, Gx). Though the effect of Ovx has been ascribed to estrogen deficiency, the weiter...
Author: Surve VV, Andersson N, Alatalo S, Lehto-Axtelius D, Halleen J, Väänänen K, Håkanson R
Source: Calcif Tissue Int., 2001; 69(5): 274-80, PMID: 11768197
GID: 528; Last update: 12.12.2007
Fundamental Studies (2001)
Parathyroid hormone (PTH) or synthetic N-terminal PTH fragments administered intermittently have been established as anabolic agents in animal and human bones. In the present study, the influence of a low calci weiter...
Author: Steiner PD, Forrer R, Kneissel M, Gasser JA, Thomsen JS, Mosekilde L, Riond JL
Source: Bone., 2001; 29(4): 344-51, PMID: 11595617
GID: 529; Last update: 12.12.2007
Fundamental Studies (2001)
Male rodent model of age-related bone loss in men
Osteoporosis is a common occurrence in aging men. There is currently no appropriate animal model for studying age-related bone loss in men. To determine whether male Sprague-Dawley (SD) rats experience bone los weiter...
Author: Wang L, Banu J, McMahan CA, Kalu DN
Source: Bone., 2001; 29(2): 141-8, PMID: 11502475
GID: 530; Last update: 12.12.2007
Fundamental Studies (2000)
Active absorbable calcium (AAACa) produced by adding HAI (heated algal ingredient) to oyster shell calcium (AACa) is quite efficiently absorbed from the intestine and can increase bone mineral density in elderl weiter...
Author: Fujita T, Fujii Y, Goto B, Miyauchi A, Takagi Y, Kobayashi S, Kamoshita K, Mikuni N, Kurihara Y, Shikauchi I
Source: J Bone Miner Metab., 2000; 18(3): 165-9, PMID: 10783851
GID: 511; Last update: 12.12.2007
Fundamental Studies (2001)
Nitric oxide (NO) is a pleiotropic signaling molecule that is produced by bone cells constitutively and in response to diverse stimuli such as proinflammatory cytokines, mechanical strain, and sex hormones. End weiter...
Author: Armour KE, Armour KJ, Gallagher ME, Gödecke A, Helfrich MH, Reid DM, Ralston SH
Source: Endocrinology., 2001; 142(2): 760-6, PMID: 11159848
GID: 514; Last update: 12.12.2007
Fundamental Studies (2000)
Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen rece weiter...
Author: Vidal O, Lindberg MK, Hollberg K, Baylink DJ, Andersson G, Lubahn DB, Mohan S, Gustafsson JA, Ohlsson C
Source: Proc Natl Acad Sci U S A., 2000; 97(10): 5474-9, PMID: 10805804
GID: 515; Last update: 12.12.2007
Fundamental Studies (2000)
Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha
Estrogen deficiency induces bone loss by upregulating osteoclastogenesis by mechanisms not completely defined. We found that ovariectomy-enhanced T-cell production of TNF-alpha, which, acting through the TNF-al weiter...
Author: Cenci S, Weitzmann MN, Roggia C, Namba N, Novack D, Woodring J, Pacifici R
Source: J Clin Invest., 2000; 106(10): 1229-37, PMID: 11086024
GID: 516; Last update: 12.12.2007
Fundamental Studies (2000)
The aim of this study was to evaluate the effects of different doses of androgen replacement, both on body composition and bone, in an aged male orchidectomized rat model. Testosterone was administered by 0.5, weiter...
Author: Vanderschueren D, Vandenput L, Boonen S, Van Herck E, Swinnen JV, Bouillon R
Source: Endocrinology., 2000; 141(5): 1642-7, PMID: 10803572
GID: 517; Last update: 12.12.2007
Fundamental Studies (2000)
Insulin-like growth factor I (IGF-I) is an important growth factor for bone, yet the mechanisms that mediate its anabolic activity in the skeleton are poorly understood. To examine the effects of locally produc weiter...
Author: Zhao G, Monier-Faugere MC, Langub MC, Geng Z, Nakayama T, Pike JW, Chernausek SD, Rosen CJ, Donahue LR, Malluche HH, Fagin JA, Clemens TL
Source: Endocrinology., 2000; 141(7): 2674-82, PMID: 10875273
GID: 518; Last update: 12.12.2007
Fundamental Studies (2000)
The mouse is increasingly being used as an animal model for the study of skeletal phenotypes in humans, mainly because of the ease of genetic manipulation. Biochemical markers of bone metabolism provide a valua weiter...
Author: Srivastava AK, Bhattacharyya S, Castillo G, Miyakoshi N, Mohan S, Baylink DJ
Source: Bone., 2000; 27(4): 529-33, PMID: 11033448
GID: 507; Last update: 11.12.2007
Fundamental Studies (2000)
Multiple cellular phenotypes in an insertional mutation in mouse affecting bone development
The 6093 line of transgenic mice exhibits altered bone development as a result of an insertional mutation by the transgene. Female transgenic mice show a marked kyphosis as early as 2 weeks of age. Vertebrae fr weiter...
Author: Nadon NL, Doersen CJ, Lade DA, Medina K, Thompson L, Rohrer M, Gimble JM
Source: Calcif Tissue Int., 2000; 67(6): 449-54, PMID: 11289693
GID: 508; Last update: 11.12.2007
Fundamental Studies (2001)
To study the effect of arthritis on bone mass, bone mineral density (BMD) of cancellous and cortical bone in the tibial metaphysis and diaphysis in 2- and 7-month-old rats with collagen-induced arthritis (CIA) weiter...
Author: Enokida M, Yamasaki D, Okano T, Hagino H, Morio Y, Teshima R
Source: Bone., 2001; 28(1): 87-93, PMID: 11165947
GID: 509; Last update: 11.12.2007
Fundamental Studies (2000)
Comparison of radiographic and pQCT analyses of healing rat tibial fractures
Fracture healing and callus formation have traditionally been evaluated by using X-ray radiography. Here we compared X-ray radiography and peripheral quantitative computed tomography (pQCT) in evaluating the he weiter...
Author: Jämsä T, Koivukangas A, Kippo K, Hannuniemi R, Jalovaara P, Tuukkanen J
Source: Calcif Tissue Int., 2000; 66(4): 288-91, PMID: 10742447
GID: 510; Last update: 11.12.2007
Fundamental Studies (2000)
Modulation of Strain Sensing: A New Approach for the Treatment of Osteoporosis
Author: Gasser JA
Source: J Musculoskelet Neuronal Interact., 2000; 2: 105-110
GID: 490; Last update: 10.12.2007
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Fundamental Studies (1999)
Femoral Bone Mass, Size and Density in Male and Female Growth Hormone Transgenic Mice
Author: A Weusten, EM Lochmüller, E Cindik, I Renner-Müller, G Tysarczyk-Niemeyer, E Wolf, F Eckstein
Source: Transgenics, 1999; 3: 43-50
GID: 482; Last update: 10.12.2007
Fundamental Studies (2000)
Analyse femoraler Knocheneigenschaften im MT-bGH-transgenen Mausmodell mit der hochauflösenden pQCT
Author: E Cindik, J Willnecker, E Wolf, F Eckstein
Source: Osteologie, 2000; 85-93
GID: 484; Last update: 10.12.2007
Fundamental Studies (2001)
Analysis of biomechanical effects on bone and on the muscle-bone interactions in small animal models
Animal models are suitable to study many aspects of bone structure and strength. This article reviews some general principles of current bone biomechanics and describes the scope of the available methodology fo weiter...
Author: Ferretti JL, Cointry GR, Capozza RF, Capiglioni R, Chiappe MA
Source: J Musculoskelet Neuronal Interact., 2001; 1(3): 263-74, PMID: 15758500
GID: 500; Last update: 10.12.2007
More information: Original Article
Fundamental Studies (2001)
The purpose of this study was to assess the long-term effects of aging and sex hormone deficiency on skeletal metabolism and body composition in rapidly growing male rats. Sprague-Dawley male rats were sham-ope weiter...
Author: Ke HZ, Crawford DT, Qi H, Chidsey-Frink KL, Simmons HA, Li M, Jee WS, Thompson DD
Source: J Musculoskelet Neuronal Interact., 2001; 1(3): 215-24, PMID: 15758495
GID: 502; Last update: 10.12.2007
More information: Original Article
Fundamental Studies (2001)
Previous studies have demonstrated that growth hormone (GH) has a marked anabolic effect on cortical bone, and parathyroid hormone (PTH) has been shown to increase cancellous bone markedly and cortical bone to weiter...
Author: Wang L, Orhii PB, Banu J, Kalu DN
Source: Bone., 2001; 28(2): 202-7, PMID: 11182379
GID: 503; Last update: 10.12.2007
Fundamental Studies (2000)
Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice
In this study we used a mouse model system to compare the in vivo effects of parathyroid hormone(1-34) [PTH(1-34)] with that of PTH(1-31) or PTH(2-34) analogs. Daily subcutaneous administration of PTH(1-34) for weiter...
Author: Mohan S, Kutilek S, Zhang C, Shen HG, Kodama Y, Srivastava AK, Wergedal JE, Beamer WG, Baylink DJ
Source: Bone., 2000; 27(4): 471-8, PMID: 11033441
GID: 504; Last update: 10.12.2007
Fundamental Studies (2000)
Some vegetables (commonly consumed by humans) efficiently modulate bone metabolism
We have hypothesized that some vegetables which are part of the regular human diet may contain modulators of bone metabolism. To mimic a typical Western diet with large proportions of refined components, rats w weiter...
Author: Mühlbauer RC, Li F, Lozano A, Reinli A, Tschudi I
Source: J Musculoskelet Neuronal Interact., 2000; 1(2): 137-40, PMID: 15758507
GID: 505; Last update: 10.12.2007
More information: Original Article
Fundamental Studies (2000)
Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice
Serum insulin-like growth factor-1 (IGF-1) and femoral bone mineral density (BMD) differ between two inbred strains of mice, C3H/HeJ (C3H) and C57BL/6J (B6), by approximately 30% and 50%, respectively. Similarl weiter...
Author: Rosen CJ, Churchill GA, Donahue LR, Shultz KL, Burgess JK, Powell DR, Ackert C, Beamer WG
Source: Bone., 2000; 27(4): 521-8, PMID: 11033447
GID: 506; Last update: 10.12.2007
Fundamental Studies (2001)
To test the hypothesis that factors associated with bone strength (i.e., volumetric bone mineral density [vBMD], geometry, and microstructure) have heritable components, we exploited the 12 BXH recombinant inbr weiter...
Author: Turner CH, Hsieh YF, Müller R, Bouxsein ML, Rosen CJ, McCrann ME, Donahue LR, Beamer WG
Source: J Bone Miner Res., 2001; 16(2): 206-13, PMID: 11204420
GID: 497; Last update: 10.12.2007
Fundamental Studies (2000)
The severely osteoporotic human skeleton is characterized by thin cortices and a very fragile cancellous framework. To increase the biomechanical competence of such a skeleton, powerful anabolic agents are need weiter...
Author: Mosekilde L, Tornvig L, Thomsen JS, Orhii PB, Banu MJ, Kalu DN
Source: Bone., 2000; 26(6): 643-51, PMID: 10831937
GID: 485; Last update: 10.12.2007
Fundamental Studies (1999)
Anabolic effect of aminoterminally truncated fibroblast growth factor 4 (FGF4) on bone
Fibroblast growth factor 4 (FGF4), a member of the FGF family, plays several important roles in bone development during embryogenesis. Systemic administration of FGF4 increases bone mass in rats, which suggests weiter...
Author: Kuroda S, Kasugai S, Oida S, Iimura T, Ohya K, Ohyama T
Source: Bone., 1999; 25(4): 431-7, PMID: 10511109
GID: 486; Last update: 10.12.2007
Fundamental Studies (2000)
One of the proteolytic systems produced by bone cells is the plasminogen activator/plasmin pathway, which involves the two plasminogen activators and the type 1 plasminogen activator inhibitor (PAI-1) and resul weiter...
Author: Daci E, Verstuyf A, Moermans K, Bouillon R, Carmeliet G
Source: Bone., 2000; 27(1): 97-102, PMID: 10865215
GID: 487; Last update: 10.12.2007
Fundamental Studies (2000)
As an adjunct to our efforts to identify the genes that determine peak bone density, we examined phenotypic differences between two inbred strains of mice, C3H/HeJ (C3H) and C57BL/6J (B6), which are of similar weiter...
Author: Kodama Y, Miyakoshi N, Linkhart TA, Wergedal J, Srivastava A, Beamer W, Donahue LR, Rosen C, Baylink DJ, Farley J
Source: Bone., 2000; 27(3): 445-52, PMID: 10962358
GID: 488; Last update: 10.12.2007
Fundamental Studies (2000)
Mineral density and bone strength are dissociated in long bones of rat osteopetrotic mutations
Bone mineral density (BMD) and mechanical strength generally show strong positive correlations. However, osteopetrosis is a metabolic bone disease with increased skeletal density radiographically and increased weiter...
Author: Tuukkanen J, Koivukangas A, Jämsä T, Sundquist K, Mackay CA, Marks SC Jr
Source: J Bone Miner Res., 2000; 15(10): 1905-11, PMID: 11028442
GID: 489; Last update: 10.12.2007
Fundamental Studies (2000)
PTH and interactions with bisphosphonates
We report that a therapeutic dose of the antiresorptive bisphosphonate alendronate administered to skeletally mature rats for the duration of 16 weeks significantly blunted the anabolic response to a high dose weiter...
Author: Gasser JA, Kneissel M, Thomsen JS, Mosekilde L
Source: J Musculoskelet Neuronal Interact., 2000; 1(1): 53-6, PMID: 15758526
GID: 491; Last update: 10.12.2007
More information: Original Article
Fundamental Studies (2000)
Spontaneous fracture (sfx): a mouse genetic model of defective peripubertal bone formation
A new mouse model of stage-specific bone growth failure and fracture has been recovered as an autosomal recessive mutation, designated spontaneous fracture (sfx). The sfx/sfx mice are phenotypically normal unti weiter...
Author: Beamer WG, Rosen CJ, Bronson RT, Gu W, Donahue LR, Baylink DJ, Richardson CC, Crawford GC, Barker JE
Source: Bone., 2000; 27(5): 619-26, PMID: 11062347
GID: 493; Last update: 10.12.2007
Fundamental Studies (2000)
How cancellous and cortical bones adapt to loading and growth hormone
There is great interest in the relationships between growth hormone (GH), muscle loading and bone, in part, because GH increases muscle mass which provides the largest signals that control bone modeling and rem weiter...
Author: Kalu DN, Banu J, Wang L
Source: J Musculoskelet Neuronal Interact., 2000; 1(1): 19-23, PMID: 15758520
GID: 492; Last update: 10.12.2007
More information: Original Article
Fundamental Studies (2000)
Aromatization of androgens into estrogens may be important for maintenance of the male skeleton. To address this hypothesis, we evaluated the skeletal effects of selective estrogen deficiency as induced by the weiter...
Author: Vanderschueren D, Boonen S, Ederveen AG, de Coster R, Van Herck E, Moermans K, Vandenput L, Verstuyf A, Bouillon R
Source: Bone., 2000; 27(5): 611-7, PMID: 11062346
GID: 494; Last update: 10.12.2007
Fundamental Studies (2001)
Atherogenic high-fat diet reduces bone mineralization in mice
The epidemiological correlation between osteoporosis and cardiovascular disease is independent of age, but the basis for this correlation is unknown. We previously found that atherogenic oxidized lipids inhibit weiter...
Author: Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL
Source: J Bone Miner Res., 2001; 16(1): 182-8, PMID: 11149483
GID: 495; Last update: 10.12.2007
Fundamental Studies (2001)
Previous studies have shown that 60-70% of variance in peak bone density is determined genetically. The higher the peak bone density, the less likely an individual is to eventually develop osteoporosis. Therefo weiter...
Author: Richman C, Kutilek S, Miyakoshi N, Srivastava AK, Beamer WG, Donahue LR, Rosen CJ, Wergedal JE, Baylink DJ, Mohan S
Source: J Bone Miner Res., 2001; 16(2): 386-97, PMID: 11204439
GID: 496; Last update: 10.12.2007
Fundamental Studies (2000)
The objectives of this study were to investigate the different effects on muscle mass and cancellous (proximal tibial metaphysis [PTM]) and cortical (tibial shaft [TX]) bone mass of sham-operated and orchidecto weiter...
Author: Yao W, Jee WS, Chen J, Liu H, Tam CS, Cui L, Zhou H, Setterberg RB, Frost HM
Source: J Bone Miner Res., 2000; 15(6): 1158-68, PMID: 10841185
GID: 483; Last update: 10.12.2007
Fundamental Studies (1998)
Einfluß der Laufaktivität auf die Knochenentwicklung und Beinschäden bei Broilern
Author: K Reiter, W Bessei
Source: Arch Geflügelk., 1998; 62: 247-253
GID: 476; Last update: 07.12.2007
Fundamental Studies (1998)
Möglichkeiten zur Verringerung von Beinschäden bei Broilern und Puten
Author: K Reiter, W Bessei
Source: Arch Geflügelk., 1998; 62: 145-149
GID: 475; Last update: 07.12.2007
Fundamental Studies (1999)
Author: JL Ferretti
Source: A Practical Guide for Mechanical Testing of Bone, 1999;
GID: 470; Last update: 07.12.2007
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Fundamental Studies (1999)
A non-destructive, three-dimensional technique for microstructural phenotypic characterisation of skeletal elements in genetically altered mice is presented. Preliminary data in bovine growth-hormone transgenic weiter...
Author: Graichen H, Lochmüller EM, Wolf E, Langkabel B, Stammberger T, Haubner M, Renner-Müller I, Englmeier KH, Eckstein F
Source: Anat Embryol (Berl)., 1999; 199(3): 239-48, PMID: 10068090
GID: 481; Last update: 07.12.2007
Fundamental Studies (1999)
Low-calcium-fed animals have been accepted as one of the experimental models showing a reduction in bone mass. However, the effects of short-term low-calcium feeding on bone turnover, the development of osteopr weiter...
Author: Seto H, Aoki K, Kasugai S, Ohya K
Source: Bone., 1999; 25(6): 687-95, PMID: 10593414
GID: 480; Last update: 07.12.2007
Fundamental Studies (1999)
A potential negative side effect of intermittent parathyroid hormone (PTH) therapy to treat osteoporosis is the loss of cortical bone concomitant with increased cancellous bone mass. We addressed this issue by weiter...
Author: Jerome CP, Johnson CS, Vafai HT, Kaplan KC, Bailey J, Capwell B, Fraser F, Hansen L, Ramsay H, Shadoan M, Lees CJ, Thomsen JS, Mosekilde L
Source: Bone., 1999; 25(3): 301-9, PMID: 10495134
GID: 479; Last update: 07.12.2007
Fundamental Studies (1999)
The aim of this study is to examine the effects of growth hormone, exercise, and weight loss due to food restriction on tibial diaphyseal bone and on tibial muscle mass. Thirteen-month-old female F344 rats were weiter...
Author: Banu MJ, Orhii PB, Mejia W, McCarter RJ, Mosekilde L, Thomsen JS, Kalu DN
Source: Bone., 1999; 25(4): 469-80, PMID: 10511115
GID: 478; Last update: 07.12.2007
Fundamental Studies (1999)
Quantitative computed tomography (QCT) allows for the separate densitometric examination of cortical and cancellous bone in vivo. With the new peripheral QCT (pQCT) instrument (the Norland/Stratec XCT-3000A), w weiter...
Author: Hotchkiss CE
Source: Bone., 1999; 24(2): 101-7, PMID: 9951777
GID: 477; Last update: 07.12.2007
Fundamental Studies (1999)
Calcium absorption and bone loss in ovariectomized rats fed varying levels of dietary calcium
The following studies were undertaken to examine whether estrogen deficiency impairs calcium absorption in aged rats, and to determine whether impaired calcium absorption and the level of dietary calcium are re weiter...
Author: Kalu DN, Orhii PB
Source: Calcif Tissue Int., 1999; 65(1): 73-7, PMID: 10369737
GID: 474; Last update: 07.12.2007
Fundamental Studies (1999)
The incidence of osteoporotic fractures has been associated with low bone mass. To reduce this incidence, it is therefore important to try to prevent the development of low bone mass by either increasing bone m weiter...
Author: Li F, Mühlbauer RC
Source: J Bone Miner Res., 1999; 14(8): 1457-65, PMID: 10457280
GID: 473; Last update: 07.12.2007
Fundamental Studies (1999)
Targeted expression of calcitonin gene-related peptide to osteoblasts increases bone density in mice
The neuropeptide calcitonin gene-related peptide (CGRP) is concentrated in fine sensory nerve endings innervating all tissues, including bone. CGRP inhibits osteoclasts, stimulates insulin-like growth factor I weiter...
Author: Ballica R, Valentijn K, Khachatryan A, Guerder S, Kapadia S, Gundberg C, Gilligan J, Flavell RA, Vignery A
Source: J Bone Miner Res., 1999; 14(7): 1067-74, PMID: 10404006
GID: 472; Last update: 07.12.2007
Fundamental Studies (1997)
Application of automatic image segmentation to tibiae and vertebrae from ovariectomized rats
Automatic contextual segmentation algorithms were developed to objectively identify bone compartments in pQCT images of tibiae, femora, and vertebrae. Principal advantages of this approach over existing techniq weiter...
Author: Helterbrand JD, Higgs RE Jr, Iversen PW, Tysarczyk-Niemeyer G, Sato M
Source: Bone., 1997; 21(5): 401-9, PMID: 9356733
GID: 469; Last update: 07.12.2007
Fundamental Studies (1998)
Morphometric analysis of gastrectomy-evoked osteopenia
Gastrectomy leads to osteopenia in the rat. The present study describes the effects of gastrectomy on bone morphology. Rats were subjected to gastrectomy or sham operation. Four weeks after the operation the ra weiter...
Author: Mühlbauer RC, Schenk RK, Chen D, Lehto-Axtelius D, Hâkanson R
Source: Calcif Tissue Int., 1998; 62(4): 323-6, PMID: 9504957
GID: 468; Last update: 07.12.2007
Fundamental Studies (1995)
An anabolic effect of hPTH(1-38) (s.c. doses of 200 micrograms/kg/d during 75 days) on trabecular and cortical bone mass is tomographically described in the metaphyseal region of immobilized rat femurs using pQ weiter...
Author: Ma YF, Ferretti JL, Capozza RF, Cointry G, Alippi R, Zanchetta J, Jee WS
Source: Bone, 1995; 17(4 Suppl): 321S-327S, PMID: 8579934
GID: 15; Last update: 05.12.2007
Fundamental Studies (1997)
Biosynthetic human parathyroid hormone (1-34) effects on bone quality in aged ovariectomized rats
For the first time, PTH (1-34) was found to significantly affect bone quality, femora length, and body weight of aged, ovariectomized rats. Specifically, we examined the effects of biosynthetic human PTH (1-34) weiter...
Author: Sato M, Zeng GQ, Turner CH
Source: Endocrinology., 1997; 138(10): 4330-7, PMID: 9322947
GID: 429; Last update: 05.12.2007
Fundamental Studies (1997)
Recent work has demonstrated differences in femoral bone mineral density between two common inbred strains of mice, C3H/HeJ (C3H) and C57BL/6J (B6), across a wide age range. To investigate one possible mechanis weiter...
Author: Rosen CJ, Dimai HP, Vereault D, Donahue LR, Beamer WG, Farley J, Linkhart S, Linkhart T, Mohan S, Baylink DJ
Source: Bone., 1997; 21(3): 217-23, PMID: 9276086
GID: 427; Last update: 05.12.2007
Fundamental Studies (1999)
Femoral neck is a sensitive indicator of bone loss in immobilized hind limb of mouse
The present study was carried out to evaluate a unilateral hind limb immobilization model in the mouse. The right legs of male mice (age 10-12 weeks) were immobilized for 3 weeks against the abdomen by an elast weiter...
Author: Jämsä T, Koivukangas A, Ryhänen J, Jalovaara P, Tuukkanen J
Source: J Bone Miner Res., 1999; 14(10): 1708-13, PMID: 10491218
GID: 428; Last update: 05.12.2007
Fundamental Studies (1997)
The process of bone resorption by osteoclasts involves the dissolution of mineral salts and enzymatic degradation of the mainly collagenous extracellular matrix. Cysteine proteinases, which can efficiently degr weiter...
Author: Millest AJ, Breen SA, Loveday BE, Clarkson PN, Simpson CA, Waterton JC, Johnstone D
Source: Bone., 1997; 20(5): 465-71, PMID: 9145244
GID: 426; Last update: 05.12.2007
Fundamental Studies (1996)
For the first time, raloxifene or alendronate was administered to rats immediately after ovariectomy for 10 months and compared with estrogen to elucidate mechanisms behind the raloxifene effects observed in no weiter...
Author: Sato M, Bryant HU, Iversen P, Helterbrand J, Smietana F, Bemis K, Higgs R, Turner CH, Owan I, Takano Y, Burr DB
Source: J Pharmacol Exp Ther., 1996; 279(1): 298-305, PMID: 8859007
GID: 425; Last update: 05.12.2007
Fundamental Studies (1996)
Effects of wortmannin analogs on bone in vitro and in vivo
The possible importance of phosphatidylinositol (PI) 3-kinase activity in bone resorption activity in vitro and in vivo were evaluated with synthetic wortmannin analogs in two in vitro bone resorption assays, t weiter...
Author: Sato M, Bryant HU, Dodge JA, Davis H, Matter WF, Vlahos CJ
Source: J Pharmacol Exp Ther., 1996; 277(1): 543-50, PMID: 8613966
GID: 423; Last update: 05.12.2007
Fundamental Studies (1996)
For the first time, four well-characterized compounds from four distinct chemical classes were directly compared for efficacy and potency in hone, uteri, lipids, and adipose tissues in an ovariectomized model w weiter...
Author: Sato M, Rippy MK, Bryant HU
Source: FASEB J., 1996; 10(8): 905-12, PMID: 8666168
GID: 424; Last update: 05.12.2007
Fundamental Studies (1996)
The use of peripheral quantitative computed tomography (pQCT) was investigated for the measurement of volumetric bone mineral density (BMD) in mg x cm-3. Two studies were undertaken. In the first study, the pre weiter...
Author: Breen SA, Millest AJ, Loveday BE, Johnstone D, Waterton JC
Source: Calcif Tissue Int., 1996; 58(6): 449-53, PMID: 8661488
GID: 422; Last update: 05.12.2007
Fundamental Studies (1996)
Genetic variability in adult bone density among inbred strains of mice
More than 70% of the variability in human bone density has been attributed to genetic factors as a result of studies with twins, osteoporotic families, and individuals with rare heritable bone disorders. We hav weiter...
Author: Beamer WG, Donahue LR, Rosen CJ, Baylink DJ
Source: Bone., 1996; 18(5): 397-403, PMID: 8739896
GID: 421; Last update: 05.12.2007
Fundamental Studies (1994)
Raloxifene preserves bone strength and bone mass in ovariectomized rats
We investigated the effects of raloxifene, a nonsteroidal benzothiophene, on bone strength in ovariectomized rats and compared them with estrogen treatment. Sixty ovariectomized Sprague-Dawley rats were divided weiter...
Author: Turner CH, Sato M, Bryant HU
Source: Endocrinology., 1994; 135(5): 2001-5, PMID: 7956922
GID: 420; Last update: 05.12.2007
Fundamental Studies (1995)
Comparative x-ray densitometry of bones from ovariectomized rats
Comparative analysis of dual energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT) with phantoms and rat bones showed that both are necessary to adequately quantitate ovariectomy induced weiter...
Author: Sato M
Source: Bone., 1995; 17(4 Suppl): 157S-162S, PMID: 8579911
GID: 419; Last update: 05.12.2007
Fundamental Studies (1995)
Assessing bone quantity by pQCT
We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of healthy rats treated with hPTH(1-34). The results demonstrated that high prec weiter...
Author: Gasser JA
Source: Bone., 1995; 17(4 Suppl): 145S-154S, PMID: 8579910
GID: 418; Last update: 05.12.2007
Fundamental Studies (1995)
Clinical data suggest that PTH may increase cancellous bone mass at the expense of cortical bone in human beings. In this study, the effects of PTH on whole body, axial and appendicular bone mass were studied i weiter...
Author: Jerome CP, Johnson CS, Lees CJ
Source: Bone., 1995; 17(4 Suppl): 415S-420S, PMID: 8579946
GID: 417; Last update: 05.12.2007
Fundamental Studies (1995)
Human growth hormone (hGH) and insulin-like growth factor I (IGF-I) both stimulate bone formation and have been proposed as therapeutic agents for osteoporosis. We examined the effect of hGH and IGF-I alone and weiter...
Author: Rosen HN, Chen V, Cittadini A, Greenspan SL, Douglas PS, Moses AC, Beamer WG
Source: J Bone Miner Res., 1995; 10(9): 1352-8, PMID: 7502707
GID: 416; Last update: 05.12.2007
Fundamental Studies (1995)
In studies of rat bone metabolism, trabecular bone density should be measured. Three established methods of measuring trabecular bone include trabecular bone volume by histomorphometry (BV/TV%), trabecular bone weiter...
Author: Rosen HN, Tollin S, Balena R, Middlebrooks VL, Beamer WG, Donohue LR, Rosen C, Turner A, Holick M, Greenspan SL
Source: Calcif Tissue Int., 1995; 57(1): 35-9, PMID: 7671163
GID: 415; Last update: 05.12.2007
Fundamental Studies (1995)
Six-month old rats chronically submitted to right hindlimb immobilization (IM) with mechanical overload (OL) of the left leg were treated 1 month later with 200 micrograms/kg/d of hPTH(1-38) for 15 or 75 days. weiter...
Author: Capozza R, Ma YF, Ferretti JL, Meta M, Alippi R, Zanchetta J, Jee WS
Source: Bone., 1995; 17(4 Suppl): 233S-239S, PMID: 8579922
GID: 410; Last update: 05.12.2007
Fundamental Studies (2001)
Mobil bleiben - Pflege bei Gehstörungen und Sturzgefahr
Die Selbstständigkeit älterer Menschen wird durch kaum ein anderes Problem so stark bedroht wie durch die Einschränkung der Bewegungsfähigkeit und die damit verbundene Sturzgefahr. Stürze im Alter sind zud weiter...
Author: Runge M, Rehfeld G
Source: Schlütersche Verlag , ISBN 3-87706-597-X, 2001;
GID: 318; Last update: 02.12.2007
Fundamental Studies (2004)
Fall risk assessment in very old males and females living in nursing homes
BACKGROUND: Several studies identified muscle weakness, history of falls, gait deficit and balance deficit as the most common risk factors for falls. AIMS: To determine risk factors of fall in older males and f weiter...
Author: Sieri T, Beretta G
Source: Disabil Rehabil., 2004; 26(12): 718-23, PMID: 15204494
GID: 60; Last update: 01.12.2007
Fundamental Studies (2006)
CONTEXT: Primary hyperparathyroidism (PH) is characterized by inappropriate PTH elevation with or without hypercalcemia. Bone disease involves catabolic action at cortical sites, whereas cancellous sites and ge weiter...
Author: Charopoulos I, Tournis S, Trovas G, Raptou P, Kaldrymides P, Skarandavos G, Katsalira K, Lyritis GP
Source: J Clin Endocrinol Metab, 2006; 91(5): 1748-53, PMID: 16492695
GID: 24; Last update: 24.11.2007
Fundamental Studies (1997)
Author: Gasser JA
Source: J.Jpn Soc Bone Morphom, 1997; 7: 107-10
GID: 11; Last update: 24.11.2007
Fundamental Studies (1995)
Female Wistar rats aged 3 months were ovariectomized (OX, n = 27). Three months later they were given i.v. doses of 150 (6), 300 (7), or 600 (6) ug/kg 2/wk of olpadronate during 12 weeks or left as OX controls weiter...
Author: Cointry GR, Mondelo N, Zanchetta JR, Montuori E, Ferretti JL
Source: Bone, 1995; 17(4 Suppl): 373S-378S, PMID: 8579940
GID: 14; Last update: 24.11.2007
Fundamental Studies (1995)
Assessment of bone material quality and architectural indicators by means of peripheral quantitative computed tomography (pQCT) offers a wide perspective for skeletal research employing noninvasive procedures. weiter...
Author: Ferretti JL
Source: Bone, 1995; 17(4 Suppl): 353S-364S, PMID: 8579938
GID: 13; Last update: 23.11.2007
Fundamental Studies (1995)
To extend and confirm previous data, we examined the effects of raloxifene on the proximal tibia of ovariectomized rats, aged 6 months, longitudinally and cross-sectionally by computed tomography (pQCT) and the weiter...
Author: Sato M, Kim J, Short LL, Slemenda CW, Bryant HU
Source: J Pharmacol Exp Ther, 1995; 272(3): 1252-9, PMID: 7891341
GID: 10; Last update: 23.11.2007
Fundamental Studies (1996)
Cross-sectional moment of inertia (CSMI) and volumetric cortical bone mineral density (vCtBMD) were assessed by peripheral quantitative computed tomography (pQCT) at femur midshafts from 103 Wistar female rats weiter...
Author: Ferretti JL, Capozza RF, Zanchetta JR
Source: Bone, 1996; 18(2): 97-102, PMID: 8833202
GID: 12; Last update: 23.11.2007
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