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J Musculoskelet Neuronal Interact, 2016; 16(4): 302-309, PMID: 27973382

Lower insulin sensitivity is related to lower relative muscle cross-sectional area, lower muscle density and lower handgrip force in young and middle aged non-diabetic men.

Year: 2016

Gysel T, Tonoli C, Pardaens S, Cambier D, Kaufman JM, Zmierczak HG, Goemaere S, Lapauw B, Calders P
Department of Rehabilitation Sciences and Physiotherapy, Ghent University, De Pintelaan 185, 1B3, Ghent, Belgium.


OBJECTIVES: This study investigated whether an association between insulin resistance (IR) and muscle parameters is appreciable in young healthy men, independent of obesity. Furthermore, markers of muscle metabolism and hormones/possible determinants, were explored. METHODS: 358 healthy young men were divided into a less and more insulin sensitive (LIS [age=33.2+/-5.4, BMI=23.4+/-2.3] and MIS [age=35.5+/-5.3, BMI=28.1+/-3.7]) group based on upper and lower quartile of HOMA-IR. Muscle cross-sectional area (CSA), -density, handgrip force, serum testosterone, estradiol, SHBG, Vitamin 25(OH)D, creatinine, IGF-1, IGFBP-3 and leptin levels were compared between these groups, correcting for differences in age, physical activity and fat mass. Correlations between HOMA-IR and these parameters, and between muscle measures and biochemical parameters, were calculated. RESULTS: LIS is related to lower relative muscle CSA, muscle density, muscle/fat CSA ratio, relative handgrip force and level of physical activity. Furthermore, lower levels in SHBG, testosterone, Vitamin 25(OH)D and higher leptin, IGF-1 and IGFBP-3 levels were observed in LIS. Bio available T, FT, TE2, FE2, bioavailable E2, serum and urinary creatinine levels did not differ between groups. CONCLUSION: Differences in muscle performance are already present in healthy men with lower insulin sensitivity and could be possibly modifiable risk factors for the development of type 2 diabetes.

Keywords: Insulin Resistance, Muscle Cross-sectional Area, Handgrip Strength, Estradiol
GID: 4347; Last update: 11.01.2017