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J Bone Miner Res, 2018; (): , PMID: 29394462

Sex-, ethnic- and age-specific centile curves for pQCT- and HR-pQCT-derived measures of bone structure and strength in adolescents and young adults.

Year: 2018

Gabel L, Nettlefold LA, Macdonald HM, McKay HA
Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Canada.


There are presently no adolescent centile curves for bone parameters at the tibial midshaft using peripheral quantitative computed tomography (pQCT) or at the distal radius and tibia using high-resolution pQCT (HR-pQCT). Thus, we aimed to develop sex-, ethnic-, site- and age-specific centile curves for pQCT and HR-pQCT-derived bone outcomes for youth and young adults aged 10-21 years. We acquired pQCT scans (XCT3000) at the tibial midshaft (50% site) and HR-pQCT scans (XtremeCT, Scanco Medical) at the distal radius (7% site) and tibia (8% site) in a convenience sample of participants in the mixed-longitudinal University of British Columbia Healthy Bones III Study. We scanned 778, 10-21-year-olds annually for a maximum of 11 years using pQCT (413 girls, 56% Asian; 365 boys, 54% Asian; n = 3160 observations) and 349, 10-21-year-olds annually for a maximum of 4 years using HR-pQCT (189 girls, 51% Asian; 165 boys; 50% Asian; n = 1090 observations). For pQCT, we report cortical bone mineral density (BMD), total bone cross-sectional area and polar strength-strain index. For HR-pQCT, we report standard measures: total BMD, trabecular number, thickness and bone volume fraction; and automated segmentation measures: total bone cross-sectional area, cortical BMD, porosity and thickness. We applied finite element analysis to estimate failure load. We applied the lamda, mu, sigma (LMS) method using LMS ChartMaker Light (Version 2.5, The Institute of Child Health, London, UK) to construct LMS tables and centile plots. We report sex- and age-specific centiles (3(rd) , 10(th) , 25(th) , 50(th) , 75(th) and 97(th) ) for whites and Asians for pQCT bone parameters at the tibial midshaft and HR-pQCT bone parameters at the distal radius and tibia. These centile curves might be used by clinicians and scientists to interpret values or better understand trajectories of bone parameters in clinical populations, those from different geographic regions or of different ethnic origin. This article is protected by copyright. All rights reserved.

GID: 4634; Last update: 27.02.2018