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Ann Hum Biol, 2021; (): 1-27, PMID: 33470135

Quantitative peripheral computed tomography to measure muscle area and assess lean soft tissue mass in children.

Year: 2021

Cordoba-Rodriguez DP, Iglesia I, Gomez-Bruton A, Miguel-Berges ML, Flores-Barrantes P, Casajus JA, Moreno LA, Rodriguez G
Food, Nutrition, and Health Research Group, Faculty of Science, Pontificia Universidad Javeriana, Bogota DC, Colombia.


BACKGROUND: Skeletal muscle is one of the main components of lean soft tissue mass (LSTM). Low levels in children affect locomotion, posture and increase the risk of metabolic syndrome. AIM: (1) To evaluate the association between cross-sectional muscle area (MCSA) of the lower left leg measured by quantitative peripheral computed tomography (pQCT) and total LSTM; namely, total left leg and left lower leg LSTM assessed by dual-energy X-ray absorptiometry (DXA) in a group of children (2) to examine if MCSA is a predictor of LSTM (3) to determine the ability of pQCT to identify children with low LSTM. SUBJECTS AND METHODS: Lower left leg MCSA and LSTM were measured using pQCT and DXA, respectively, in 396 children. RESULTS: Statistically significant positive correlations were found between the lower leg MCSA- total LSTM (r(2) = .789), total leg LSTM (r(2) = .79), and lower leg LSTM (r(2) = .791) (p <.01). MCSA explained 64-68% of the variance in LSTM.ROC curves determined the capacity of the lower left leg MCSA to identify low LSTM in girls (AUC 0.95) and boys (AUC 0.87). CONCLUSIONS: Our results showed that lower left leg MCSA, measured using pQCT, could be a tool to predict low LSTM in children.

GID: 5280; Last update: 25.01.2021