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Nutrients, 2021; 13(5): , PMID: 33922947

Plasma Fatty Acids and Quantitative Ultrasound, DXA and pQCT Derived Parameters in Postmenopausal Spanish Women.

Year: 2021

Roncero-Martin R, Aliaga I, Moran JM, Puerto-Parejo LM, Rey-Sanchez P, de la Luz Canal-Macias M, Sanchez-Fernandez A, Pedrera-Zamorano JD, Lopez-Espuela F, Vera V, Cerrato-Carretero P, Lavado-Garcia JM
Metabolic Bone Diseases Research Group, Nursing and Occupational Therapy College, University of Extremadura, 10003 Caceres, Spain.


Different factors may contribute to the development of osteopenia or osteoporosis. Fatty acids are key nutrients for health, and a number of studies have reported an association between bone mineral density (BMD) and fatty acid intake. We aimed to investigate the relationships between serum levels of different fatty acids and bone parameters determined by quantitative bone ultrasound (QUS), peripheral quantitative computed tomography (pQCT), and dual-energy X-ray absorptiometry (DXA) in a sample of Spanish postmenopausal women. We enrolled a total of 301 postmenopausal women (median age 59 years; interquartile range (IQR) 7) in this study. All participants underwent full densitometric screening, including calcaneal quantitative ultrasound (QUS), peripheral quantitative computed tomography (pQCT), and dual-energy X-ray absorptiometry (DXA), as well as plasma fatty acid measurement. After adjustment for potential confounders, plasma n-3 polyunsaturated fatty acid (PUFA) levels correlated with BMD in the spine (r = 0.150; p = 0.014) and femoral neck (r = 0.143; p = 0.019). By multiple linear regression, an independent statistically significant positive relationship was observed between BMD in the spine and BMI (beta = 0.288; p = 0.001) as well as total plasma n-3 PUFAs (beta = 0.155; p = 0.009). The plasma n-3 PUFA level was also a significant and positive predictor of BMD at the femoral neck (beta = 0.146; p = 0.009). Independent risk factors for low BMD (T-score
GID: 5395; Last update: 03.05.2021