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J Clin Densitom, 2021; (): , PMID: 34391642

Sclerostin and Dickkopf-1 Characteristics According to Age and Physical Activity Levels in Premenopausal Women.

Year: 2021

Sharma-Ghimire P, Buchanan S, Bemben MG, Knehans A, Campbell J, Bemben DA
Department of Physical Education and Exercise Science, Lander University, Greenwood, SC, USA. Electronic address:


We aimed to compare serum concentrations of sclerostin and DKK-1 in young (20-30 yrs, n=25) and middle-aged (35-45 yrs, n=25) premenopausal women and based on physical activity (PA) status. PA status was assessed by the International Physical Activity Questionnaire (low-moderate (/= 3000 MET-min/week). Serum sclerostin and DKK-1 levels were measured in fasting morning blood samples by ELISA. Areal bone mineral density (aBMD) was measured by DXA, and non-dominant tibia bone characteristics were assessed by pQCT. After adjusting for total body aBMD, middle-aged women had significantly (p < 0.001) higher (0.54 +/- 0.01 ng/mL) serum sclerostin than young women (0.41 +/- 0.01 ng/mL), and sclerostin was positively correlated with age (rs=0.065, p
GID: 5528; Last update: 30.08.2021