Bitte aktivieren Sie JavaScript in Ihrem Browser um unseren Internetauftritt optimal nutzen zu können.

J Clin Endocrinol Metab, 2017; (102): 2734-2743, PMID: 28472303

The effect of whole body vibration training on bone and muscle function in children with osteogenesis imperfecta.

Jahr: 2017

Hogler W, Scott J, Bishop N, Arundel P, Nightingale P, Mughal MZ, Padidela R, Shaw N, Crabtree N
Department of Endocrinology & Diabetes, Birmingham Children"s Hospital, Birmingham, UK.


Context: Osteogenesis imperfecta (OI) is a bone fragility disorder associated with reduced muscle size, dynamic muscle function and mobility. Objective: To assess the effect of whole body vibration (WBV) training on bone density and geometry, muscle size and function, mobility, and balance in children with OI. Design: Randomised controlled pilot trial. Setting: Tertiary paediatric research centre. Participants: Twenty-four children (5-16 years) with OI types 1,4 and limited mobility (CHAQ score >/=0.13) recruited in gender- and pubertal stage-matched pairs. Incident fractures in two boys (WBV arm) led to exclusion of two prepubertal male pairs. Intervention: 5 months of WBV training (3x3min twice daily) or regular care. Main Outcome Measures: Bone and muscle variables measured by dual-energy X-ray absorptiometry (lumbar spine, hip, total body) and peripheral quantitative computed tomography (distal and proximal tibia). Mobility assessed by six-minute walk tests and CHAQ; dynamic muscle function by mechanography. Results: All participants had reduced walking distances and dynamic muscle function (p<0.001). BMI Z-score was associated with higher CHAQ scores (rho +0.552; p=0.005) and lower walking and two-leg jumping performance (rho -0.405 to -0.654, p<0.05). The WBV and control groups did not differ in the 5-month changes in bone density or geometry. Total lean mass increased more in the WBV group (+1119g [+224 to +1744]) compared to controls (+635g [-951 to +1006]), p=0.01, without improving mobility, muscle function or balance. Conclusions: The increase in lean mass without changes in muscle function or bone mass suggests reduced biomechanical responsiveness of the muscle-bone unit in children with OI.

Schlagworte: OI, Mechanography,
GID: 4436; Letzte Änderung: 08.05.2017