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Triangle., 1992; 31(2/3): 77-88, PMID: 11539347

Skeletal adaptations during growth

Year: 1992

Jee WS, Frost HM
Radiobiology Division, University of Utah, Salt Lake City 84112, USA.


NASA: The authors examine the role of mechanical usage in skeletal development. Principle mechanisms of bone physiology include longitudinal bone growth; modeling drifts; micromodeling; remodeling by the basic multicellular unit and its effects on bone mass, bone turnover, and bone gain or loss; setpoint effects; microdamage and its repair; and the effects of mechanical usage. Biomechanical explanations for the architecture of growing long bones are examined. Clinical problems that involve principal biological mechanisms include osteopenia; influence of hormones, cytokines, drugs, other agents, and setpoints; osteoporosis and bone fragility; stress fractures; homeostasis and calcium; and fracture healing.

GID: 2078; Last update: 25.11.2009