Open Access Dissertations and Theses. Paper 8464, 2013;
A TRI-MODALITY COMPARISON OF VOLUMETRIC BONE MEASURE QUANTIFICATION USING 1.0 TESLA PERIPHERAL MAGNETIC RESONANCE
IMAGING, PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY AND HIGHRESOLUTION- PERIPHERAL QUANTITATIVE COMPUTED
TOMOGRAPHY IMAGES
Year: 2013
Wong A.K.O.
McMaster University, Canada
Abstract
This comparative study of peripheral (p) QCT, high-resolution pQCT (hr-pQCT) and 1.0Tesla pMRI technologies focused on quantifying short-term test-retest reproducibility,
validity, one-year detection limit and clinical sensitivity of each modality’s derived bone
measures. Select bone outcomes were evaluated from scans performed on Hamiltonian
women above 50 years old and then externally validated in a population-based cohort of
Canadian women 60-85 years old. In the local cohort (age: 74 ± 9 years and BMI 27.65 ±
5.74 kg/m2), Tb.Sp measured on pMRI, Ct.Th and vBMD from pQCT showed significant
correlations (r2=0.52-0.85) with hr-pQCT and yielded slopes near unity. Bland-Altman
analyses revealed significant relations between magnitude of pQCT and pMRI bone
outcomes (Tb.Th(-), Tb.N(+), BV/TV(-)) and level of agreement with hr-pQCT. Except
for hole geometry and connectivity, short-term reproducibility was < 5% for pQCT but
only BV/TV was < 5% for pMRI. The more distal slice of pQCT scans at both sites
showed superior reproducibility but slightly larger change than the proximal. Coregistering
repeat images and excluding those on antiresorptive therapy mildly reduced
precision error and one-year change. In the local cohort, only Ct.Th and cortical vBMD
associated with fragility fractures (OR: 1.09-3.28) using hr-pQCT, which was externally
validated in the national cohort. Certain trabecular measures on pMRI and pQCT erred
towards increased odds for fractures locally. For pQCT, these became significant in the
national cohort (OR:1.04-3.81). The national reference dataset for hr-pQCT showed
larger Tb.Sp and smaller Tb.N compared to Americans but age-related rates of decline in
Ct.Th and BV/TV were larger in Europeans. This study demonstrated validity of pMRI
and pQCT image-derived volumetric bone outcomes and a reasonable degree of shortand
long-term precision error for measures derived from pQCT images but not from 1.0T
pMRI. For pMRI, a shorter scan was suggested to limit motion and to reduce precision
error. Performing scans more distally was recommended, but a single CT slice from
pQCT was comparable to 110 slices from hr-pQCT in associations with fractures.
Keywords: Morphometric parameters pQCT vs. HR-pQCT
GID: 3342; Last update: 06.11.2013
More information: Original Article
