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Ultrasound Med Biol, 2019; 45(51234-1242): , PMID: 30777311

In Vivo Measurements of Cortical Thickness and Porosity at the Proximal Third of the Tibia Using Guided Waves: Comparison with Site-Matched Peripheral Quantitative Computed Tomography and Distal High-Resolution Peripheral Quantitative Computed Tomography

Year: 2019

Schneider J, Ramiandrisoa D, Armbrecht G, Ritter Z, Felsenberg D, Raum K, Minonzio JG
Berlin-Brandenburg School for Regenerative Therapies (BSRT), Charite-Universitatsmedizin Berlin, Berlin, Germany.


The aim of this study was to estimate cortical porosity (Ct.Po) and cortical thickness (Ct.Th) using 500-kHz bi-directional axial transmission (AT). Ct.ThAT and Ct.PoAT were obtained at the tibia in 15 patients from a 2-D transverse isotropic free plate model fitted to measured guided wave dispersion curves. The velocities of the first arriving signal (upsilonFAS) and A0 mode (upsilonA0) were also determined. Site-matched peripheral quantitative computed tomography (pQCT) provided volumetric cortical bone mineral density (Ct.vBMDpQCT) and Ct.ThpQCT. Good agreement was found between Ct.ThAT and Ct.ThpQCT (R(2)=0.62, root mean square error [RMSE]=0.39 mm). Ct.vBMDpQCT correlated with Ct.PoAT (R(2)=0.57), upsilonFAS (R(2)=0.43) and upsilonA0 (R(2)=0.28). Furthermore, a significant correlation was found between AT and distal high-resolution pQCT. The measurement of cortical parameters at the tibia using guided waves might improve the prediction of bone fractures in a cost-effective and radiation-free manner.

GID: 4864; Last update: 26.02.2019