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Literature (651)

Research Studies (2022)

Beneficial effects of denosumab on muscle performance in patients with low BMD: a retrospective, propensity score-matched study.

This study examined the effects of denosumab compared to bisphosphonates and vitamin D alone on muscle performance in patients with low BMD. While grip force improved in both the denosumab and bisphosphonate g weiter...

Author: Rupp T, von Vopelius E, Strahl A, Oheim R, Barvencik F, Amling M, Rolvien T
Source: Osteoporos Int, 2022; (): , PMID: 35751664
GID: 5735; Last update: 28.06.2022

Research Studies (2022)

The effect of Functional Electrical Stimulation-assisted posture-shifting in bone mineral density: case series-pilot study.

STUDY DESIGN: A training intervention study using standing dynamic load-shifting Functional Electrical Stimulation (FES) in a group of individuals with complete spinal cord injury (SCI) T2 to T10. OBJECTIVES: weiter...

Author: Armengol M, Zoulias ID, Gibbons RS, McCarthy I, Andrews BJ, Harwin WS, Holderbaum W
Source: Spinal Cord Ser Cases, 2022; 8(1): 60, PMID: 35680785
GID: 5730; Last update: 14.06.2022

Research Studies (2022)

Peak power and body mass as predictors of tibial bone strength in healthy male and female adults.

OBJECTIVE: The purpose of this study was to examine whether a non-invasive, muscular fitness field test was a better predictor of bone strength compared to body mass in healthy adults. METHODS: Hierarchical mul weiter...

Author: Denys AT, Bugayong JC, Juhala CC, Ma EJ, Carvalho KE, Kwong SM, Yingling VR
Source: J Musculoskelet Neuronal Interact, 2022; 22(2): 154-160, PMID: 35642695
GID: 5722; Last update: 02.06.2022
More information: Original Article

Research Studies (2022)

Sex differences in tibial adaptations to arduous training: An observational cohort study.

Military training increases tibial density and size, but it is unknown if men and women adapt similarly to the same arduous training. Seventy-seven men and 57 women not using hormonal contraceptives completed t weiter...

Author: O"Leary TJ, Izard RM, Tang JCY, Fraser WD, Greeves JP
Source: Bone, 2022; 160(): 116426, PMID: 35470123
GID: 5698; Last update: 02.05.2022

Research Studies (2018)

Randomised study of children with obesity showed that whole body vibration reduced sclerostin.

AIM: New strategies are required to increase physical activity and improve metabolic profiles in children with obesity. We studied the effect of whole body vibration (WBV) on children with obesity on biochemic weiter...

Author: Tubic B, Zeijlon R, Wennergren G, Obermayer-Pietsch B, Marild S, Dahlgren J, Magnusson P, Swolin-Eide D
Source: Acta Paediatr, 2018; 108(3): 502-513, PMID: 30071142
GID: 5697; Last update: 26.04.2022

Research Studies (2022)

Physical function and physical activity in adults with X-linked hypophosphatemia.

We described physical function and activity in UK adults with X-linked hypophosphatemia (XLH). Our data indicate that low physical activity and impaired mobility are common in adults with XLH. Deficits in lower weiter...

Author: Orlando G, Bubbear J, Clarke S, Keen R, Roy M, Anilkumar A, Schini M, Walsh JS, Javaid MK, Ireland A
Source: Osteoporos Int, 2022; 33(7): 1485-1491, PMID: 35122145
GID: 5687; Last update: 25.04.2022

Research Studies (2021)

Combination of DXA and BIS Predicts Jump Power Better Than Traditional Measures of Sarcopenia.

Traditional diagnostic criteria for sarcopenia use dual-energy X-ray absorptiometry (DXA)-measured appendicular lean mass (ALM), normalized to height (ALM/ht(2)) or body mass index (ALM/BMI) to define low musc weiter...

Author: Rush B, Binkley N, Krueger D, Yamada Y, Kuchnia AJ
Source: JBMR Plus, 2021; 5(8): e10527, PMID: 34368612
GID: 5685; Last update: 25.04.2022

Research Studies (2022)

Effect of semi-recumbent vibration exercise on muscle outcomes in older adults: a pilot randomized controlled clinical trial.

BACKGROUND: Many older adults with physical limitations living in residential care apartments are unable to exercise in a standing position and are at risk for declining in muscle function leading to falls and weiter...

Author: Taani MH, Binkley N, Gangnon R, Krueger D, Buehring B
Source: BMC Geriatr, 2022; 22(1): 335, PMID: 35436920
Keywords: seated leg vibration
GID: 5686; Last update: 25.04.2022

Research Studies (2022)

Neuromuscular conditions and the impact of cystine-depleting therapy in infantile nephropathic cystinosis: A cross-sectional analysis of 55 patients.

Infantile nephropathic cystinosis (INC) is a rare lysosomal storage disease caused by biallelic mutations in the cystinosin gene, leading to cystine accumulation in various organs. The aim of this cross-section weiter...

Author: Vill K, Muller-Felber W, Landfarth T, Koppl C, Herzig N, Knerr C, Holla H, Steidle G, Harms E, Hohenfellner K
Source: J Inherit Metab Dis, 2022; 45(2): 183-191, PMID: 34888877
GID: 5688; Last update: 25.04.2022

Research Studies (2021)

Association between sarcopenia, physical performance and falls in patients with rheumatoid arthritis: a 1-year prospective study.

BACKGROUND: Patients with rheumatoid arthritis (RA) are at increased risk of falls and fractures. Sarcopenia occurs more frequently in RA patients due to the inflammatory processes. Early diagnosis and prevent weiter...

Author: Wiegmann S, Armbrecht G, Borucki D, Buehring B, Buttgereit F, Detzer C, Schaumburg D, Zeiner KN, Dietzel R
Source: BMC Musculoskelet Disord, 2021; 22(1): 885, PMID: 34663280
GID: 5689; Last update: 25.04.2022

Research Studies (2022)

Bone Density, Geometry, and Mass by Peripheral Quantitative Computed Tomography and Bone Turnover Markers in Children with Diabetes Mellitus Type 1

Background. The type 1 diabetes mellitus (T1DM) is a chronic systemic autoimmune-mediated disease characterised by the insulin deficiency and hyperglycaemia. Its deleterious effect on bones concerns not only bo weiter...

Author: Maciej Jaworski, Elzbieta Wierzbicka, Edyta Czekuc-Kryskiewicz, Pawel Pludowski, Maria Kobylinska, Mieczysaw Szalecki
Source: Journal of Diabetes Research,, 2022; 9261512: , PMID: 35480630
GID: 5684; Last update: 21.04.2022
More information: Original Article

Research Studies (2022)

Bone accrual and structural changes over one year in youth with cystic fibrosis.

Background: Pediatric bone accrual governs peak bone mass and strength. Longitudinal studies of bone health in youth with cystic fibrosis (CF) may provide insight into CF-related bone disease (CFBD), a prevalen weiter...

Author: Bass RM, Zemel BS, Stallings VA, Leonard MB, Tsao J, Kelly A
Source: J Clin Transl Endocrinol, 2022; 28(): 100297, PMID: 35433270
GID: 5683; Last update: 20.04.2022

Research Studies (2022)

Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: A nested study within a randomized placebo controlled trial.

The effect of levothyroxine (LT4) therapy for subclinical hypothyroidism (SHypo) on appendicular bone geometry and volumetric density has so far not been studied. In a nested study within the randomized, place weiter...

Author: Buchi AE, Feller M, Netzer S, Blum MR, Rodriguez EG, Collet TH, Del Giovane C, van Heemst D, Quinn T, Kearney PM, Westendorp RGJ, Gussekloo J, Mooijaart S, Hans D, Bauer DC, Rodondi N, Aeberli D
Source: Bone, 2022; 161 (): 116404, PMID: 35381390
GID: 5679; Last update: 11.04.2022

Research Studies (2022)

Subject factors influencing blood flow restriction in the arm at low cuff pressures.

BACKGROUND: Limb circumference predicts the pressure needed for complete occlusion. However, that relationship is inconsistent at moderate pressures typical of effective blood flow restriction (BFR) training. T weiter...

Author: Meek AW, Heavrin AM, Mikesky AE, Segal NA, Riley ZA
Source: Clin Physiol Funct Imaging, 2022; 42(4): 233-240, PMID: 35319161
Keywords: anthropometrics; composition; limb circumference.
GID: 5673; Last update: 04.04.2022

Research Studies (2022)

Forearm Fractures in Overweight-Obese Children and Adolescents: A Matter of Bone Density, Bone Geometry or Body Composition?

Forearm fractures in children and adolescents are associated with increased body mass index (BMI). This bone site is non-weight-bearing and therefore is appropriate to explore the effect of BMI on bone mineral weiter...

Author: Franceschi R, Radetti G, Soffiati M, Maines E
Source: Calcif Tissue Int doi: 10.1007/s00223-022-00971-3, 2022; PMID: 35316361
GID: 5674; Last update: 04.04.2022

Research Studies (2022)

Open-Label Pilot Study of Interferon Gamma-1b in Patients With Non-Infantile Osteopetrosis.

The only treatment currently available for patients with severe infantile osteopetrosis is hematopoietic cell transplantation (HCT). HCT-related toxicity and mortality risks typically preclude its use in non-in weiter...

Author: Nguyen A, Miller WP, Gupta A, Lund TC, Schiferl D, Lam LSK, Arzumanyan Z, Orchard PJ, Polgreen LE
Source: JBMR Plus, 2022; 6(3): e10597, PMID: 35309862
GID: 5676; Last update: 04.04.2022

Research Studies (2022)

Modest changes in sex hormones during early and middle adulthood affect bone mass and size in healthy men. A prospective cohort study.

Bone metabolism in men is in part determined by sex steroid exposure. This is especially clear during puberty and senescence but it remains to be established whether declines in sex steroid levels during young weiter...

Author: Banica T, Verroken C, T"Sjoen G, Goemaere S, Zmierczak HG, Fiers T, Kaufman JM, Lapauw B
Source: J Bone Miner Res, 2022; 37(5): 865-875, PMID: 35279881
Keywords: AGING; BONE GEOMETRY; BONE MASS; EVOLUTION; HEALTHY MEN; SEX STEROIDS.
GID: 5667; Last update: 21.03.2022

Research Studies (2022)

Between-Subject and Within-Subject Variaton of Muscle Atrophy and Bone Loss in Response to Experimental Bed Rest.

To improve quantification of individual responses to bed rest interventions, we analyzed peripheral quantitative computer tomography (pQCT) datasets of the lower leg of 76 participants, who took part in eight d weiter...

Author: Bocker J, Schmitz MT, Mittag U, Jordan J, Rittweger J
Source: Front Physiol, 2022; 12(): 743876, PMID: 35273514
GID: 5661; Last update: 15.03.2022

Research Studies (2022)

The skeletal muscle phenotype of children with Neurofibromatosis Type 1 - A clinical perspective.

Neurofibromatosis type 1 (NF1) can affect multiple systems in the body. An under recognised phenotype is one of muscle weakness. Clinical studies using dynamometry and jumping mechanography have demonstrated t weiter...

Author: Chinoy A, Vassallo GR, Burkitt Wright E, Eelloo J, West S, Hupton E, Galloway P, Pilkington A, Padidela R, Mughal MZ
Source: J Musculoskelet Neuronal Interact, 2022; 22(1): 70-78, PMID: 35234161
GID: 5651; Last update: 07.03.2022

Research Studies (2022)

Correlation of muscle and bone parameters, daily function and participation in women with generalized joint hypermobility: a descriptive evaluation.

OBJECTIVES: Generalized joint hypermobility (GJH) has a prevalence in women of 15% to 35%. GJH may lead to impaired movement control, frequent sprains or subluxations and pain, and can be associated with early weiter...

Author: Luder G, Aeberli D, Mueller Mebes C, Haupt-Bertschy B, Verra ML, Baeyens JP
Source: J Musculoskelet Neuronal Interact, 2022; 22(1): 15-26, PMID: 35234155
GID: 5653; Last update: 07.03.2022

Research Studies (2022)

Tibial Bone Geometry Is Associated With Bone Stress Injury During Military Training in Men and Women.

Bone stress injuries (BSI) are a common musculoskeletal condition among exercising and military populations and present a major burden to military readiness. The purpose of this investigation was to determine w weiter...

Author: Koltun KJ, Sekel NM, Bird MB, Lovalekar M, Mi Q, Martin BJ, Nindl BC
Source: Front Physiol, 2022; 13(): 803219, PMID: 35222074
GID: 5654; Last update: 07.03.2022

Research Studies (2022)

Determinants of muscle power and force as assessed by Jumping Mechanography in rural Indian children.

OBJECTIVES: To: 1. Assess muscle function (MF) of rural Indian children (6-11y, n=232), using Jumping Mechanography (JM) and hand dynamometer, 2. Investigate gender differences, 3. Identify determinants of MF. weiter...

Author: Kasture S, Padidela R, Rawer R, Ekbote V, Gondhalekar K, Khadilkar V, Khadilkar A
Source: J Musculoskelet Neuronal Interact, 2022; 22(1): 43-51, PMID: 35234158
GID: 5656; Last update: 07.03.2022

Research Studies (2022)

Assessment of Activity Profiles in Older Adults and Lower Limb Bone Parameters: Observations from the Hertfordshire Cohort Study.

As muscle strength and function decline with age the optimal high-impact physical activity (PA) required for bone remodelling is rarely achievable in older adults. This study aimed to explore the activity profi weiter...

Author: Parsons CM, Dennison EM, Fuggle N, Breasail MO, Deere K, Hannam K, Tobias JH, Cooper C, Ward KA
Source: Calcif Tissue Int, 2022; (): , PMID: 35212826
GID: 5648; Last update: 03.03.2022

Research Studies (2022)

Intermittent fasting and continuous energy restriction result in similar changes in body composition and muscle strength when combined with a 12 week resistance training program.

PURPOSE: The objective of this study was to compare the effects of 12 weeks of resistance training combined with either 5:2 intermittent fasting or continuous energy restriction on body composition, muscle size weiter...

Author: Keenan SJ, Cooke MB, Hassan EB, Chen WS, Sullivan J, Wu SX, El-Ansary D, Imani M, Belski R
Source: Eur J Nutr, 2022; 61(4): 2183-2199, PMID: 35084574
GID: 5636; Last update: 01.02.2022

Research Studies (2022)

Persistent Musculoskeletal Deficits in Pediatric, Adolescent and Young Adult Survivors of Allogeneic Hematopoietic Stem-Cell Transplantation.

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a common therapy for pediatric hematologic malignancies. With improved supportive care, addressing treatment-related late effects is at the foref weiter...

Author: Kindler JM, Guo M, Baker J, McCormack S, Armenian SH, Zemel BS, Leonard MB, Mostoufi-Moab S
Source: J Bone Miner Res, 2022; 37(4): 794-803, PMID: 35080067
GID: 5637; Last update: 01.02.2022

Research Studies (2022)

Associations of serum IL-6 with muscle, bone, and adipose tissue in women.

This cross-sectional study examined the associations between serum interleukin-6 (IL-6) and muscle, bone, and fat parameters in recreationally active women. One-hundred forty-five women (48.7 +/- 17.8 years; 1 weiter...

Author: Miller RM, Freitas EDS, Heishman AD, Peak KM, Buchanan SR, Bemben DA, Bemben MG
Source: Cytokine, 2022; 151(): 155787, PMID: 35065509
GID: 5631; Last update: 26.01.2022

Research Studies (2022)

Fatty Liver Index and Skeletal Muscle Density.

Accumulation of fat in the liver and skeletal muscle is associated with obesity and poor health outcomes. Liver steatosis is a characteristic of non-alcoholic fatty liver disease (NAFLD) and myosteatosis, of po weiter...

Author: Pasco JA, Sui SX, West EC, Anderson KB, Rufus-Membere P, Tembo MC, Hyde NK, Williams LJ, Liu ZSJ, Kotowicz MA
Source: Calcif Tissue Int, 2022; 110(6): 649-657, PMID: 35028685
GID: 5627; Last update: 18.01.2022

Research Studies (2022)

Evaluation of Increasing Dairy Intake on Bone Density in Post-pubertal Youth: A Randomized Controlled Trial Using Motivational Interviewing.

BACKGROUND: Adequate nutrition is important for bone health, especially for bone mineral accretion. OBJECTIVE: The primary objective tested whether increasing dairy intake using the motivational interviewing t weiter...

Author: Slim M, Vanstone CA, Morin SN, Rahme E, Bacon SL, Weiler HA
Source: J Nutr, 2022; 152(4): 1031-1041, PMID: 35015862
GID: 5628; Last update: 18.01.2022

Research Studies (2022)

Correlation of muscle and bone parameters, daily function and participation in women with generalized joint hypermobility: a descriptive evaluation

Objectives: Generalized joint hypermobility GJH) has a prevalence in women of 15% to 35%. GJH may lead to impaired movement control, frequent sprains or subluxations and pain, and can be associated with early o weiter...

Author: Gere Luder, Daniel Aeberli, Christine Mueller Mebes, Bettina Haupt-Bertschy,Martin L. Verra, Jean-Pierre Baeyens
Source: J Musculoskelet Neuronal Interact, 2022; 22(1): 15-26, PMID: 35234155
Keywords: Beighton Score, Disability, Muscle Cross-Sectional-Area, Muscle Strength, Stair Climbing
GID: 5630; Last update: 18.01.2022

Research Studies (2021)

Assessment of Intramuscular Fat and Correlation with Body Composition in Patients with Rheumatoid Arthritis and Spondyloarthritis: A Pilot Study.

Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are associated with changes in body composition. Ectopic intramuscular fat (IMAT) may alter muscle function and contribute to cardiometabolic disorders. In weiter...

Author: Villedon de Naide M, Pereira B, Courteix D, Dutheil F, Cassagnes L, Boirie Y, Soubrier M, Tournadre A
Source: Nutrients, 2021; 13(12): , PMID: 34960085
GID: 5610; Last update: 10.01.2022

Research Studies (2021)

Site-Specific Bone Differences and Energy Status in Male Competitive Runners and Road Cyclists.

The interaction between mechanical loading and energy availability on bone health in male endurance athletes merits further investigation. The purpose of this study was to compare bone status in male competitiv weiter...

Author: Chen Z, Sherk VD, Sharma-Ghimire P, Bemben MG, Bemben DA
Source: J Clin Densitom, 2021; (): , PMID: 34952789
GID: 5611; Last update: 10.01.2022

Research Studies (2021)

A proposal for the adjustment of bone mineral density for body dimensions in children.

Objectives: The precise age estimation is of high importance in bone mineral density (BMD) assessment in children, since the bone structure of a studied child is evaluated by using the age and gender dependent weiter...

Author: Annar D, Feher P, Zsakai A, Muzsnai A
Source: Anthropol Anz, 2021; (): , PMID: 34931217
GID: 5613; Last update: 10.01.2022

Research Studies (2021)

Impact of adolescent pregnancy on bone density in underprivileged pre-menopausal Indian women.

High prevalence (31.5%) of adolescent pregnancies (AP) have been reported in India. Reports suggest that pregnancy during adolescence may have deleterious effects on peak bone mass. Very few studies have descri weiter...

Author: Kajale N, Khadilkar A, Shah N, Padidela R, Mughal Z, Chiplonkar S, Ekbote V, Khadilkar V
Source: J Clin Densitom, 2021; (): , PMID: 34911660
GID: 5623; Last update: 10.01.2022

Research Studies (2022)

Is it important to achieve physical activity recommendations at early stages of life to improve bone health?

Research in bone health during childhood is limited and important to prevent future diseases, particularly, osteoporosis. Bone parameters using DXA and pQCT in 295 Spanish children were evaluated and we found a weiter...

Author: Ferrer P, Iglesia I, Muniz-Pardos B, Miguel-Berges ML, Flores-Barrantes P, Gomez-Bruton A, Moreno LA, Rodriguez G
Source: Osteoporos Int, 2022; 33(5): 1017-1026, PMID: 34905063
GID: 5624; Last update: 10.01.2022

Research Studies (2020)

Exploring changes in bone mass in individuals with a chronic spinal cord injury.

People experience rapid bone loss shortly after a spinal cord injury (SCI), but the long-term bone changes are yet to be confirmed. This study showed that trabecular bone may have reached a steady state, wherea weiter...

Author: El-Kotob R, Craven BC, Thabane L, Papaioannou A, Adachi JD, Giangregorio LM
Source: Osteoporos Int, 2020; 32(4): 759-767, PMID: 33089353
GID: 5602; Last update: 06.12.2021

Research Studies (2021)

Associations between parameters of peripheral quantitative computed tomography and bone material strength index.

BACKGROUND: Bone material strength index (BMSi) is measured in vivo using impact microindentation (IMI). However, the associations between BMSi and other bone measures are not clear. This study investigated wh weiter...

Author: Holloway-Kew KL, Rufus-Membere P, Anderson KB, Tembo MC, Sui SX, Hyde NK, Diez-Perez A, Kotowicz MA, Pasco JA
Source: Bone, 2021; 155(): 116268, PMID: 34856422
GID: 5600; Last update: 06.12.2021

Research Studies (2021)

Peripheral quantitative computed tomography (pQCT) measures are associated with prior low trauma fracture in men.

Peripheral quantitative computed tomography (pQCT) assesses bone quantity and quality, complementary to current standard practice, and has potential to improve prediction of fracture risk. This study explored w weiter...

Author: Anderson KB, Tembo MC, Sui SX, Hyde NK, Pasco JA, Kotowicz MA, Holloway-Kew KL
Source: Arch Osteoporos, 2021; 16(1): 178, PMID: 34825263
GID: 5595; Last update: 30.11.2021

Research Studies (2021)

Divergent effects of sex and calcium/vitamin D supplementation on serum magnesium and markers of bone structure and function during initial military training.

Maintaining magnesium status may be important for military recruits, a population that experiences high rates of stress fracture during initial military training (IMT). The objectives of this secondary analysis weiter...

Author: Hennigar SR, Kelley AM, Nakayama AT, Anderson BJ, McClung JP, Gaffney-Stomberg E
Source: Br J Nutr, 2021; (): 1-8, PMID: 34814952
GID: 5596; Last update: 30.11.2021

Research Studies (2021)

Cessation of ambulation results in a dramatic loss of trabecular bone density in boys with Duchenne muscular dystrophy (DMD).

Glucocorticoids are currently used to improve muscle strength and prolong ambulation in boys with DMD although the effect on bone health is still unclear. The aim of this study was to compare bone strength in weiter...

Author: Crabtree NJ, Roper H, Shaw NJ
Source: Bone, 2021; (): 116248, PMID: 34718220
GID: 5580; Last update: 09.11.2021

Research Studies (2021)

Myofibril and Mitochondrial Area Changes in Type I and II Fibers Following 10 Weeks of Resistance Training in Previously Untrained Men.

Resistance training increases muscle fiber hypertrophy, but the morphological adaptations that occur within muscle fibers remain largely unresolved. Fifteen males with minimal training experience (24+/-4years, weiter...

Author: Ruple BA, Godwin JS, Mesquita PHC, Osburn SC, Sexton CL, Smith MA, Ogletree JC, Goodlett MD, Edison JL, Ferrando AA, Fruge AD, Kavazis AN, Young KC, Roberts MD
Source: Front Physiol, 2021; 12(): 728683, PMID: 34630147
GID: 5568; Last update: 18.10.2021

Research Studies (2021)

Development of Tibia & Fibula Bone Deficits in Children With Neurofibromatosis Type I - A Longitudinal Case-Control Comparison

Neurofibromatosis type 1 (NF1) is associated with lower bone mass and increased risk of fracture. Children with NF1 display faltering growth from mid-childhood. However, to date tibia bone development in child weiter...

Author: Ireland A, Riddell A, Prentice A, Eelloo J, Zulf Mughal M, Ward KA
Source: Bone, 2021; (): 116183, PMID: 34600162
GID: 5564; Last update: 12.10.2021

Research Studies (2021)

Examining effects of habitual physical activity and body composition on bone structure in early post-menopausal women: a pQCT analysis.

After menopause, bones decline in structure and can break more easily. Physical activity can strengthen bones. This study investigated how activity and body composition can impact bone structure in post-menopau weiter...

Author: Flores LE, Nelson S, Waltman N, Kupzyk K, Lappe J, Mack L, Bilek LD
Source: Osteoporos Int, 2021; (): , PMID: 34510230
GID: 5550; Last update: 21.09.2021

Scientific Publications (2021)

Peripheral Quantitative Computed Tomography Derived Muscle Density Is Associated With Physical Performance in Older Adults.

PURPOSE: The assessment of body composition is an integral part in diagnosing sarcopenia. The purpose of this study was to determine the relationships between peripheral quantitative computed tomography (pQCT) weiter...

Author: Martini S, Petermeise S, Henkel M, Weiss S, Schaupp A, Ferrari U, Schmidmaier R, Drey M
Source: Arch Gerontol Geriatr, 2021; 97(): 104512, PMID: 34481136
GID: 5542; Last update: 07.09.2021

Research Studies (2021)

Teriparatide and stress fracture healing in young adults (RETURN - Research on Efficacy of Teriparatide Use in the Return of recruits to Normal duty): study protocol for a randomised controlled trial.

BACKGROUND: Stress fractures are a common and potentially debilitating overuse injury to bone and occur frequently among military recruits and athletes. Recovery from a lower body stress fracture typically requ weiter...

Author: Carswell AT, Eastman KG, Casey A, Hammond M, Shepstone L, Payerne E, Toms AP, MacKay JW, Swart AM, Greeves JP, Fraser WD
Source: Trials, 2021; 22(1): 580, PMID: 34461961
GID: 5543; Last update: 07.09.2021

Research Studies (2021)

Sinus-like versus random vibration: Acute effects on elderly people with a high risk of falling.

BACKGROUND: Whole-body vibration (WBV) could be an alternative training method for elderly with a high risk of falling. RESEARCH QUESTION: What acute effects of sinus-like and random WBV intervention occur in t weiter...

Author: Kiehl A, Stein L, Kerling A, Tegtbur U, Kaeding TS
Source: Gait Posture, 2021; 90(): 36-42, PMID: 34385027
GID: 5533; Last update: 30.08.2021

Research Studies (2021)

Differential relationships between parent-child DXA and pQCT bone measures: Results from the Southampton Women"s Survey.

AIM: To investigate the associations between indices of bone health in childhood and corresponding parental measures. METHODS: The Southampton Women"s Survey characterised 12,583 non-pregnant women aged 20-34 weiter...

Author: Holroyd CR, Carter S, Crozier SR, D"Angelo S, Curtis EM, Moon RJ, Davies JH, Ward KA, Dennison EM, Inskip HM, Godfrey KM, Cooper C, Harvey NC
Source: Bone, 2021; 153(): 116134, PMID: 34332160
GID: 5538; Last update: 30.08.2021

Research Studies (2021)

The acute effect of the menstrual cycle and oral contraceptive cycle on measures of body composition.

PURPOSE: This study aimed to investigate the effect of fluctuating female hormones during the menstrual cycle (MC) and oral contraceptive (OC) cycle on different measures of body composition. METHODS: Twenty-tw weiter...

Author: Thompson BM, Hillebrandt HL, Sculley DV, Barba-Moreno L, Janse de Jonge XAK
Source: Eur J Appl Physiol, 2021; 121(11): 3051-3059, PMID: 34296342
GID: 5539; Last update: 30.08.2021

Research Studies (2021)

Sclerostin and Dickkopf-1 Characteristics According to Age and Physical Activity Levels in Premenopausal Women.

We aimed to compare serum concentrations of sclerostin and DKK-1 in young (20-30 yrs, n=25) and middle-aged (35-45 yrs, n=25) premenopausal women and based on physical activity (PA) status. PA status was asses weiter...

Author: Sharma-Ghimire P, Buchanan S, Bemben MG, Knehans A, Campbell J, Bemben DA
Source: J Clin Densitom, 2021; (): , PMID: 34391642
GID: 5528; Last update: 30.08.2021

Research Studies (2021)

A systematic review and meta-analysis of pediatric normative peripheral quantitative computed tomography data

Background: Peripheral-quantitative computed tomography (pQCT) provides an intriguing diagnostic alternative to dual-energy X-ray absorptiometry (DXA) since it can measure 3D bone geometry and differentiates b weiter...

Author: M. Medeleanu, R. Vali, S. Sadeghpour,
Source: Bone Reports (2018), https://doi.org/10.1016/j.bonr.2021.101103, 2021; PMID: 34377749
GID: 5517; Last update: 27.07.2021

Research Studies (2021)

Bone, Biomarker, Body Composition, and Performance Responses to 8 Weeks of ROTC Training.

CONTEXT: Military personnel engage in vigorous exercise, often resulting in higher bone mineral density; however, lower leg bone injuries are common in this population. Predictors of change in tibial bone qual weiter...

Author: Baker BS, Buchanan SR, Black CD, Bemben MG, Bemben DA
Source: J Athl Train, 2021; (): , PMID: 34279654
GID: 5516; Last update: 26.07.2021

Research Studies (2021)

Bone Mineral Density and Type 1 Diabetes in Children and Adolescents: A Meta-analysis.

BACKGROUND: There is substantial evidence that adults with type 1 diabetes have reduced bone mineral density (BMD); however, findings in youth are inconsistent. PURPOSE: To perform a systematic review and meta weiter...

Author: Loxton P, Narayan K, Munns CF, Craig ME
Source: Diabetes Care, 2021; (): , PMID: 34285100
GID: 5515; Last update: 26.07.2021

Research Studies (2021)

Bone health in long-term survivors of pediatric acute lymphoblastic leukemia. An assessment by peripheral quantitative computed tomography.

BACKGROUND: Loss of bone mineral is a common concomitant of the treatment of acute lymphoblastic leukemia (ALL) due mainly to chemotherapy, especially with corticosteroids. Osteopenia/osteoporosis may be encoun weiter...

Author: Barr RD, Inglis D, Athale U, Jaworski M, Farncombe T, Gordon CL
Source: Pediatr Blood Cancer, 2021; (): e29218, PMID: 34264535
GID: 5494; Last update: 19.07.2021

Research Studies (2021)

A Three-Year Longitudinal Study Comparing Bone Mass, Density, and Geometry Measured by DXA, pQCT, and Bone Turnover Markers in Children with PKU Taking L-Amino Acid or Glycomacropeptide Protein Substitutes.

In patients with phenylketonuria (PKU), treated by diet therapy only, evidence suggests that areal bone mineral density (BMDa) is within the normal clinical reference range but is below the population norm. AIM weiter...

Author: Daly A, Hogler W, Crabtree N, Shaw N, Evans S, Pinto A, Jackson R, Ashmore C, Rocha JC, Strauss BJ, Wilcox G, Fraser WD, Tang JCY, MacDonald A
Source: Nutrients, 2021; 13(6): , PMID: 34204378
GID: 5469; Last update: 05.07.2021

Research Studies (2021)

Mechanography assessment of fall risk in older adults: the Vietnam Osteoporosis Study.

BACKGROUND: Jumping mechanography is a technology for quantitatively assessing muscular function and balance in older adults. This study sought to define the association between jumping mechanography parameters weiter...

Author: Hoang DK, Le NM, Vo-Thi UP, Nguyen HG, Ho-Pham LT, Nguyen TV
Source: J Cachexia Sarcopenia Muscle, 2021; (): , PMID: 34196127
GID: 5464; Last update: 02.07.2021
More information: Original Article

Research Studies (2020)

Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years.

At birth, the neonatal skeleton contains 20 to 30 g calcium (Ca). It is hypothesized maternal bone mineral may be mobilized to support fetal skeletal development, although evidence of pregnancy-induced mineral weiter...

Author: O Breasail M, Prentice A, Ward K
Source: J Bone Miner Res, 2020; 35(7): 1253-1262, PMID: 32119748
GID: 5423; Last update: 17.05.2021

Research Studies (2019)

Effect of prenatal calcium supplementation on bone during pregnancy and 1 y postpartum.

Background: Low calcium intake during pregnancy may cause maternal skeletal calcium mobilization to meet fetal needs. The Recommended Dietary Allowance (RDA) for calcium in nonpregnant, pregnant, or lactating w weiter...

Author: Cullers A, King JC, Van Loan M, Gildengorin G, Fung EB
Source: Am J Clin Nutr, 2019; 109(1): 197-206, PMID: 30649176
GID: 5424; Last update: 17.05.2021

Research Studies (2021)

Whole-body vibration training versus conventional balance training in patients with severe COPD-a randomized, controlled trial.

BACKGROUND: Whole-body vibration training (WBV) performed on a vibration platform can significantly improve physical performance in patients with chronic obstructive pulmonary disease. It has been suggested tha weiter...

Author: Gloeckl R, Schneeberger T, Leitl D, Reinold T, Nell C, Jarosch I, Kenn K, Koczulla AR
Source: Respir Res, 2021; 22(1): 138, PMID: 33947416
Keywords: COPD, Balance, Power, Leistung, #GRFS174, #GRFS176
GID: 5420; Last update: 06.05.2021
More information: Original Article

Research Studies (2021)

Associations between Daily Movement Distribution, Bone Structure, Falls, and Fractures in Older Adults: A Compositional Data Analysis Study.

With aging, bone density is reduced, increasing the risk of suffering osteoporosis and fractures. Increasing physical activity (PA) may have preventive effects. However, until now, no studies have considered mo weiter...

Author: Moradell A, Rodriguez-Gomez I, Fernandez-Garcia AI, Navarrete-Villanueva D, Marin-Puyalto J, Perez-Gomez J, Villa-Vicente JG, Gonzalez-Gross M, Ara I, Casajus JA, Gomez-Cabello A, Vicente-Rodriguez G
Source: Int J Environ Res Public Health, 2021; 18(7): , PMID: 33916857
GID: 5396; Last update: 03.05.2021

Research Studies (2021)

Plasma Fatty Acids and Quantitative Ultrasound, DXA and pQCT Derived Parameters in Postmenopausal Spanish Women.

Different factors may contribute to the development of osteopenia or osteoporosis. Fatty acids are key nutrients for health, and a number of studies have reported an association between bone mineral density (BM weiter...

Author: Roncero-Martin R, Aliaga I, Moran JM, Puerto-Parejo LM, Rey-Sanchez P, de la Luz Canal-Macias M, Sanchez-Fernandez A, Pedrera-Zamorano JD, Lopez-Espuela F, Vera V, Cerrato-Carretero P, Lavado-Garcia JM
Source: Nutrients, 2021; 13(5): , PMID: 33922947
GID: 5395; Last update: 03.05.2021

Research Studies (2021)

Musculoskeletal Responses to Exercise plus Nutrition in Men with Prostate Cancer on Androgen Deprivation: A 12-month RCT.

PURPOSE: Androgen deprivation therapy (ADT) for prostate cancer (PCa) has multiple adverse effects on musculoskeletal health. This 12-month randomised controlled trial aimed to assess the effects of multi-compo weiter...

Author: Via JD, Owen PJ, Daly RM, Mundell NL, Livingston PM, Rantalainen T, Foulkes SJ, Millar JL, Murphy DG, Fraser SF
Source: Med Sci Sports Exerc, 2021; (): , PMID: 33867499
GID: 5391; Last update: 26.04.2021

Research Studies (2020)

Muscle force interacts with stature to influence functionally related polar second moments of area in the lower limb among adult women.

OBJECTIVES: We sought to determine the relationships between muscle size, function, and polar second moments of area (J) at the midshaft femur, proximal tibia, and midshaft tibia. MATERIALS AND METHODS: We used weiter...

Author: Murray AA, Stock JT
Source: Am J Phys Anthropol, 2020; 173(2): 258-275, PMID: 32735047
GID: 5382; Last update: 07.04.2021

Research Studies (2021)

Bone Structure Assessed with pQCT in Prepubertal Males with Delayed Puberty or Congenital Hypogonadotropic Hypogonadism.

OBJECTIVE: Congenital hypogonadotropic hypogonadism (CHH) is associated with impaired bone mineral density in adulthood, whereas the estimates on bone structure in adolescents with CHH has not been previously e weiter...

Author: Varimo T, Miettinen J PJ, Laine T, Salonen P, Tenhola S, Voutilainen R, Huopio H, Hero M, Raivio T
Source: Clin Endocrinol (Oxf), 2021; (): , PMID: 33738832
GID: 5333; Last update: 22.03.2021

Research Studies (2021)

Peripheral quantitative computed tomography of the lower leg in children and adolescents: bone densities, cross-sectional sizes and muscle distribution reference data

Objectives: Peripheral quantitative computed tomography is utilised in increasing numbers of paediatric studies, however, very little is known about the reference limits for pQCT tibia measurements. The purpose weiter...

Author: Maciej Jaworski, Maria Kobyliñska, Krzysztof Graff
Source: J Musculoskelet Neuronal Interact, 2021; 21(2): 215-236, PMID: 34059567
GID: 5321; Last update: 08.03.2021

Research Studies (2018)

Effect of Higher vs Standard Dosage of Vitamin D3 Supplementation on Bone Strength and Infection in Healthy Infants: A Randomized Clinical Trial.

Importance: Although guidelines for vitamin D supplementation in infants have been widely implemented, they are mostly based on studies focusing on prevention of rickets. The optimal dose for bone strength and weiter...

Author: Rosendahl J, Valkama S, Holmlund-Suila E, Enlund-Cerullo M, Hauta-Alus H, Helve O, Hytinantti T, Levalahti E, Kajantie E, Viljakainen H, Makitie O, Andersson S
Source: JAMA Pediatr, 2018; 172(7): 646-654, PMID: 29813149
GID: 5302; Last update: 19.02.2021

Research Studies (2021)

Does Vitamin D affects changes in volumetric bone mineral density and architecture in postmenopausal women after conservatively treated distal radius fractures?

Objective: We examined the role of vitamin D on volumetric bone mineral density (vBMD) and architecture during the first weekfs post-fracture in postmenopausal women (PMW) with distal radial fractures (DRF) t weiter...

Author: Konstantinos Raptis, Konstantinos Makris, George Trovas, Antonios Galanos, Christos Koutserimpas, Nikolaos Papaioannou, Ioannis Vlamis, Konstantinos Vlasis, Symeon Tournis
Source: J Musculoskelet Neuronal Interact, 2021; 21(1): 93-103, PMID: 33657759
GID: 5292; Last update: 04.02.2021

Research Studies (2021)

Longitudinal changes in muscle power compared to muscle strength and mass

Objectives: The study reports longitudinal changes in grip strength, muscle mass and muscle power of lower extremities. The aim is to identify early muscular changes to improve the diagnosis and treatment of sa weiter...

Author: Sabine Wiegmann, Dieter Felsenberg, Gabriele Armbrecht, Roswitha Dietzel
Source: J Musculoskelet Neuronal Interact, 2021; 21(1): 13-25, PMID: 33657752
Keywords: Aging, Longitudinal, Mechanography, Muscle Power, Sarcopenia
GID: 5293; Last update: 04.02.2021

Scientific Publications (2020)

Bone health in young adult survivors born extremely preterm or extremely low birthweight in the post surfactant era.

BACKGROUND: Most infants born extremely preterm (EP; <28 weeks" gestation) or extremely low birthweight (ELBW; <1000 g birthweight) in the post surfactant era (early 1990s) are now surviving into adulthood. Pr weiter...

Author: Haikerwal A, Doyle LW, Patton G, Garland SM, Cheung MM, Wark JD, Cheong JLY
Source: Bone, 2020; 143(): 115648, PMID: 32950698
GID: 5283; Last update: 02.02.2021

Research Studies (2021)

Quantitative peripheral computed tomography to measure muscle area and assess lean soft tissue mass in children.

BACKGROUND: Skeletal muscle is one of the main components of lean soft tissue mass (LSTM). Low levels in children affect locomotion, posture and increase the risk of metabolic syndrome. AIM: (1) To evaluate the weiter...

Author: Cordoba-Rodriguez DP, Iglesia I, Gomez-Bruton A, Miguel-Berges ML, Flores-Barrantes P, Casajus JA, Moreno LA, Rodriguez G
Source: Ann Hum Biol, 2021; (): 1-27, PMID: 33470135
GID: 5280; Last update: 25.01.2021

Scientific Publications (2009)

Bone volumetric density, geometry, and strength in female and male collegiate runners.

PURPOSE: To explore differences in tibial bone geometry, volumetric density, and estimates of bone strength in runners and healthy controls. METHODS: Male (n = 21) and female (n = 38) runners (49.1 +/- 13.2 mi weiter...

Author: Smock AJ, Hughes JM, Popp KL, Wetzsteon RJ, Stovitz SD, Kaufman BC, Kurzer MS, Petit MA
Source: Med Sci Sports Exerc, 2009; 41(11): 2026-32, PMID: 19812515
GID: 5272; Last update: 18.01.2021

Research Studies (2021)

Effects of different vibration frequencies on muscle strength, bone turnover and walking endurance in chronic stroke.

This randomized controlled trial aimed to evaluate the effects of different whole body vibration (WBV) frequencies on concentric and eccentric leg muscle strength, bone turnover and walking endurance after stro weiter...

Author: Yang Z, Miller T, Xiang Z, Pang MYC
Source: Sci Rep, 2021; 11(1): 121, PMID: 33420277
GID: 5263; Last update: 11.01.2021

Research Studies (2020)

The effects of resistance training with or without peanut protein supplementation on skeletal muscle and strength adaptations in older individuals.

Several studies suggest resistance training (RT) while supplementing with various protein supplements can enhance strength and muscle mass in older individuals. However, to date, no study has examined the effec weiter...

Author: Lamb DA, Moore JH, Smith MA, Vann CG, Osburn SC, Ruple BA, Fox CD, Smith KS, Altonji OM, Power ZM, Cerovsky AE, Ross CO, Cao AT, Goodlett MD, Huggins KW, Fruge AD, Young KC, Roberts MD
Source: J Int Soc Sports Nutr, 2020; 17(1): 66, PMID: 33317565
GID: 5268; Last update: 11.01.2021

Research Studies (2020)

Trabecular Bone Score has Poor Association With pQCT Derived Trabecular Bone Density in Indian Children With Type 1 Diabetes and Healthy Controls.

BACKGROUND: In children with type 1 diabetes mellitus (T1DM), low trabecular volumetric bone mineral density (Trab vBMD) has been reported. However, studies using the trabecular bone score (TBS) are scarce. The weiter...

Author: Wagh A, Ekbote V, Khadilkar V, Khadilkar A
Source: J Clin Densitom, 2020; (): , PMID: 33358221
GID: 5265; Last update: 11.01.2021

Research Studies (2021)

Effect of Low-Intensity Vibration on Bone Strength, Microstructure, and Adiposity in Pre-Osteoporotic Postmenopausal Women: A Randomized Placebo-Controlled Trial.

There has been evidence that cyclical mechanical stimulation may be osteogenic, thus providing opportunities for nonpharmacological treatment of degenerative bone disease. Here, we applied this technology to a weiter...

Author: Rajapakse CS, Johncola AJ, Batzdorf AS, Jones BC, Al Mukaddam M, Sexton K, Shults J, Leonard MB, Snyder PJ, Wehrli FW
Source: J Bone Miner Res, 2021; 36(4): 673-684, PMID: 33314313
GID: 5269; Last update: 11.01.2021

Professional Articles (2020)

Impact of a multimodal exercise program on tibial bone health in adolescents with Development Coordination Disorder: an examination of feasibility and potential efficacy.

OBJECTIVES: Developmental coordination disorder (DCD) compromises bone health purportedly due to lower levels of physical activity. The potential of an exercise intervention to improve bone health parameters in weiter...

Author: Tan JL, Siafarikas A, Rantalainen T, Hart NH, McIntyre F, Hands B, Chivers P
Source: J Musculoskelet Neuronal Interact, 2020; 20(4): 445-471, PMID: 33265073
GID: 5245; Last update: 07.12.2020

Professional Articles (2020)

Stable bone density in adolescents with severe growth hormone deficiency after six months off rhGH.

OBJECTIVE: Severe growth hormone deficiency causes lean body mass loss in male adolescents and increased fat mass in both sexes. The changes appear after a 6 month GH pause. AIM: The aim was to examine bone den weiter...

Author: Schweizer R, Donner J, von Lukowicz B, Bauer JL, Binder G
Source: Bone, 2020; (142): 115771, PMID: 33246146
GID: 5239; Last update: 03.12.2020

Research Studies (2020)

Administration of Denosumab Preserves Bone Mineral Density at the Knee in Persons With Subacute Spinal Cord Injury: Findings From a Randomized Clinical Trial.

Persons with neurologically motor-complete spinal cord injury (SCI) have a marked loss of bone mineral density (BMD) of the long bones of the lower extremities, predisposing them to fragility fractures, especia weiter...

Author: Cirnigliaro CM, La Fountaine MF, Parrott JS, Kirshblum SC, McKenna C, Sauer SJ, Shapses SA, Hao L, McClure IA, Hobson JC, Spungen AM, Bauman WA
Source: JBMR Plus, 2020; 4(8): e10375, PMID: 33134767
GID: 5220; Last update: 09.11.2020

Research Studies (2021)

DXA and pQCT derived parameters in Indian children with beta thalassemia major - A case controlled study.

Children with beta thalassemia major (BTM) are known to have reduced bone mass which increases incidence of non-traumatic fractures. Few studies have assessed prevalence of fractures and bone health in underpri weiter...

Author: Shah N, Khadilkar A, Ekbote V, Mughal Z, Gondhalekar K, Khadilkar S, Ramanan V, Khadilkar V, Padidela R
Source: Bone, 2021; 143(): 115730, PMID: 33137537
GID: 5219; Last update: 09.11.2020

Research Studies (2021)

Sex-specific associations between cardiac workload, peripheral vascular calcification and bone mineral density: The Gambian Bone and Muscle Ageing Study.

Non-communicable diseases (NCD) are rapidly rising in Africa, with multi-morbidity increasing the burden on health and social care. Osteoporosis and cardiovascular disease (CVD) both share common risk factors; weiter...

Author: Zengin A, Jarjou LM, Janha RE, Prentice A, Cooper C, Ebeling PR, Ward KA
Source: J Bone Miner Res, 2021; 36(2): 227-235, PMID: 33118663
GID: 5216; Last update: 02.11.2020

Scientific Publications (2021)

Studying Bone Mineral Density in Young People: The Complexity of choosing a pQCT Reference Database.

BACKGROUND: Many chronic illnesses affect bone health, and commonly lead to mineralization abnormalities in young people. As cortical and trabecular bone may be differentially affected in certain diseases, an i weiter...

Author: Lalayiannis AD, Fewtrell M, Biassoni L, Silva S, Goodman N, Shroff R, Crabtree NJ
Source: Bone, 2021; 143(): 115713, PMID: 33122089
GID: 5215; Last update: 02.11.2020

Research Studies (2020)

Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance.

Objective: Monoclonal Gammopathy of Undetermined Significance (MGUS) is a risk factor for reduced physical performance, osteoporosis, and fractures due to compromised musculoskeletal metabolism. In this conditi weiter...

Author: Seefried L, Genest F, Stromsdorfer J, Engelmann B, Lapa C, Jakob F, Baumann FT, Sperlich B, Jundt F
Source: J Bone Oncol, 2020; 25(): 100323, PMID: 33083217
GID: 5211; Last update: 26.10.2020
More information: Original Article

Scientific Publications (2020)

Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women.

BACKGROUND: Osteoporosis affects elderly patients of both sexes. It is characterized by an increased fracture risk due to defective remodeling of the bone microarchitecture. It affects in particular postmenopau weiter...

Author: Jackle K, Kolb JP, Schilling AF, Schlickewei C, Amling M, Rueger JM, Lehmann W
Source: BMC Musculoskelet Disord, 2020; 21(1): 693, PMID: 33076902
GID: 5212; Last update: 26.10.2020

Research Studies (2020)

Radiographic imaging, densitometry and disease severity in Autosomal dominant osteopetrosis type 2.

OBJECTIVE: To characterize relationships between quantitative computed tomography bone mineral density measurements and other qualitative and quantitative imaging measures, as well as clinical metrics, in pati weiter...

Author: Ladd LM, Imel EA, Niziolek PJ, Liu Z, Warden SJ, Liang Y, Econs MJ
Source: Skeletal Radiol, 2020; 50(5): 903-913, PMID: 33009917
GID: 5204; Last update: 05.10.2020

Scientific Publications (2020)

Loss of bone density and bone strength following premenopausal risk-reducing bilateral salpingo-oophorectomy: a prospective controlled study (WHAM Study).

Prophylactic oophorectomy is recommended for women at high risk for ovarian cancer, but the associated impact on bone health is of clinical concern. This prospective, controlled study demonstrated substantial l weiter...

Author: Jiang H, Robinson DL, Lee PVS, Krejany EO, Yates CJ, Hickey M, Wark JD
Source: Osteoporos Int, 2020; (): , PMID: 32856124
Keywords: DXA . Finite element analysis . Hormone replacement . pQCT . Surgical menopause
GID: 5186; Last update: 31.08.2020

Research Studies (2020)

Associations between Physical Fitness, Bone Mass, and Structure in Older People.

The main aim was to analyse the associations between several physical fitness variables and bone parameters in a sample of elderly people. 129 participants (94 females and 35 males, 76.2 +/- 5.4 y) from the EXE weiter...

Author: Moradell A, Gomez-Cabello A, Gomez-Bruton A, Muniz-Pardos B, Puyalto JM, Matute-Llorente A, Gonzalez-Aguero A, Ara I, Casajus JA, Vicente-Rodriguez G
Source: Biomed Res Int, 2020; 2020(): 6930682, PMID: 32733950
GID: 5183; Last update: 25.08.2020

Scientific Publications (2020)

Total urinary polyphenols and longitudinal changes of bone properties. The InCHIANTI study.

The aim of this study was to evaluate the association of levels of urinary total polyphenols considered as a proxy measure of polyphenol intake, with longitudinal changes of bone properties, in the InCHIANTI s weiter...

Author: Di Iorio A, Abate M, Bandinelli S, Barassi G, Cherubini A, Andres-Lacueva C, Zamora-Ros R, Paganelli R, Volpato S, Ferrucci L
Source: Osteoporos Int, 2020; (): , PMID: 32793995
GID: 5179; Last update: 25.08.2020

Scientific Publications (2020)

Naturally occurring stable calcium isotope ratios in body compartments provide a novel biomarker of bone mineral balance in children and young adults.

Serum calcium (Ca), bone biomarkers and radiological imaging do not allow accurate evaluation of bone mineral balance (BMB), a key determinant of bone mineral density (BMD) and fracture risk. We studied natural weiter...

Author: Shroff R, Fewtrell M, Heuser A, Kolevica A, Lalayiannis A, McAlister L, Silva S, Goodman N, Schmitt CP, Biassoni L, Rahn A, Fischer DC, Eisenhauer A
Source: J Bone Miner Res, 2020; (): , PMID: 32786145
GID: 5181; Last update: 25.08.2020

Scientific Publications (2020)

Established paths and new avenues: a review of the main radiological techniques for investigating sarcopenia.

Sarcopenia is a clinical condition mainly affecting the elderly that can be associated in a long run with severe consequences like malnutrition and frailty. Considering the progressive ageing of the world popu weiter...

Author: Giraudo C, Cavaliere A, Lupi A, Guglielmi G, Quaia E
Source: Quant Imaging Med Surg, 2020; 10(8): 1602-1613, PMID: 32742955
GID: 5182; Last update: 25.08.2020

Research Studies (2020)

Bone Geometry and Microarchitecture Deficits in Children with Alagille Syndrome.

Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our object weiter...

Author: Kindler JM, Mitchell EL, Piccoli DA, Grimberg A, Leonard MB, Loomes KM, Zemel BS
Source: Bone, 2020; 141(): 115576, PMID: 32791330
GID: 5180; Last update: 25.08.2020

Research Studies (2020)

Influence of Changes in Soft Tissue Composition on Changes in Bone Strength in Peri-Pubertal Girls: The STAR Longitudinal Study.

Obesity and osteoporosis remain two major public health concerns. Soft tissue composition and bone are interrelated; however, it is still not well understood how changes in adiposity during adolescence affect b weiter...

Author: Bland VL, Bea JW, Blew RM, Roe DJ, Lee VR, Funk JL, Going SB
Source: J Bone Miner Res, 2020; (): , PMID: 32810295
GID: 5174; Last update: 24.08.2020

Research Studies (2020)

Bone Measures by Dual-Energy X-Ray Absorptiometry and Peripheral Quantitative Computed Tomography in Young Women With Type 1 Diabetes Mellitus.

Understanding bone fragility in young adult females with type 1 diabetes mellitus (T1DM) is of great clinical importance since the high fracture risk in this population remains unexplained. This study aimed to weiter...

Author: Jiang H, Robinson DL, Nankervis A, Garland SM, Callegari ET, Price S, Lee PVS, Wark JD
Source: J Clin Densitom, 2020; 24(2): 259-267, PMID: 32586681
GID: 5151; Last update: 29.06.2020

Research Studies (2020)

Association of objectively measured physical activity and bone health in children and adolescents: a systematic review and narrative synthesis.

The influence of day-to-day physical activity on bone in adolescence has not been well characterized. Forty articles were identified that assessed the relationship between accelerometry-derived physical activit weiter...

Author: Bland VL, Heatherington-Rauth M, Howe C, Going SB, Bea JW
Source: Osteoporos Int, 2020; 31(10): 1865-1894, PMID: 32542544
GID: 5148; Last update: 22.06.2020

Research Studies (2020)

Pediatric Reference Ranges for Ultradistal Radius Bone Density: Results from the Bone Mineral Density in Childhood Study.

CONTEXT: The ultradistal (UD) radius is rich in trabecular bone and is easily measured by dual energy X-ray absorptiometry (DXA). UD radius areal bone mineral density (aBMD) may help identify trabecular bone d weiter...

Author: Kindler JM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield S, Shepherd JA, Kelly A, Winer KK, Zemel BS
Source: J Clin Endocrinol Metab, 2020; 105(10): 3529-3539, PMID: 32561914
GID: 5147; Last update: 22.06.2020

Fundamental Studies (2020)

Analysis of low-dose estrogen on fracture healing measured by pQCT in postmenopausal women

Background The skeletal disease osteoporosis affects primarily postmenopausal women. It is characterized by increased fracture risk due to defective remodeling of bone tissue and a pathological bone microarchi weiter...

Author: Katharina Blanka Dr. Jäckle, Jan Philipp Kolb, Arndt F Schilling
Source: PREPRINT (Version 1) available at Research Square [+https://doi.org/10.21203/rs.3.rs-29939/v1+], 2020;
Keywords: estrogen, fracture healing, osteoporosis, callus formation
GID: 5144; Last update: 16.06.2020

Scientific Publications (2020)

Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study.

BACKGROUND: Predictors of bone deterioration after hip fracture have not been well characterized. The aim of this study was to examine the associations of physical function and lean body mass (LBM) with loss of weiter...

Author: Suominen TH, Edgren J, Salpakoski A, Kallinen M, Cervinka T, Rantalainen T, Tormakangas T, Heinonen A, Sipila S
Source: BMC Musculoskelet Disord, 2020; 21(1): 367, PMID: 32517755
Keywords: Aging, Bone mineral density, Hip fracture, Lean body mass, Physical function, pQCT
GID: 5140; Last update: 15.06.2020

Research Studies (2020)

Are jumping mechanography assessed muscle force and power, and traditional physical capability measures associated with falls in older adults? Results from the Hertfordshire Cohort Study.

OBJECTIVES: To explore associations between measures of lower limb muscle force, velocity and power from jumping mechanography (JM) and simple physical capability (PC) testing, and falls in community dwelling weiter...

Author: Parsons CM, Edwards MH, Cooper C, Dennison EM, Ward KA
Source: J Musculoskelet Neuronal Interact, 2020; 20(2): 168-175, PMID: 32481232
Keywords: Ageing, Epidemiology, Falls, Jump, Muscle, Physical Capability, Leonardo Mechanography, Fall Risk
GID: 5132; Last update: 05.06.2020

Research Studies (2019)

Evaluation of physical performance in musculoskeletal and rheumatic diseases with jumping mechanography.

Objective: Low muscle function is a component of sarcopenia. Rheumatic and musculoskeletal diseases are related to increased muscle loss and decreased muscle performance. Our purpose was to study muscle functio weiter...

Author: Dionyssiotis Y, Skarantavos G, Kantaidou I, Papadatou MC, Papagelopoulos P, Angoules A, Papathanasiou J, Lyritis GP
Source: J Frailty Sarcopenia Falls, 2019; 4(4): 116-121, PMID: 32300726
Keywords: Sarcopenia, Jumping mechanography, Rheumatic diseases, Osteoporosis, Menopause
GID: 5133; Last update: 05.06.2020

Scientific Publications (2020)

Bone Densities and Bone Geometry in Children and Adolescents With Arthrogryposis

Objective: To describe bone densitometry results using lumbar spine dual-energy X-ray absorptiometry and forearm peripheral quantitative computed tomography (pQCT) in children with arthrogryposis multiplex cong weiter...

Author: Noemi Dahan-Oliel 1 , Jessica Collins 2 , Damian Rauch 2 , Gloria Bukovy 2 , Reggie Hamdy 3 , Frank Rauch 4
Source: Bone, 2020; 137: 115454, PMID: 32464275
Keywords: Arthrogryposis; Bone mineral density; Children; Fat and muscle mass.
GID: 5128; Last update: 03.06.2020

Scientific Publications (2020)

Interscholastic Athletics and Bone Strength: The Iowa Bone Development Study.

Pashkova, A, Hartman, JM, Letuchy, EM, and Janz, KF. Interscholastic athletics and bone strength: the Iowa bone development study. J Strength Cond Res XX(X): 000-000, 2020-The objective of this study was to det weiter...

Author: Pashkova A, Hartman JM, Letuchy EM, Janz KF.
Source: J Strength Cond Res. 2020 May 25;, 2020; PMID: 32459739
GID: 5129; Last update: 03.06.2020

Research Studies (2019)

Gender specific paediatric reference data for muscle function parameters assessed using jumping mechanography

Objective: Bone adapts to mechanical stimuli by increasing its mass and changing geometry; muscles are the stimulators for this change as they induce forces through contractions. Thus, bone strength is driven b weiter...

Author: Palande S., Ekbote V., Chiplonkar S., Padidela R., Mughal Z., Vispute S., Rawer R., Khadilkar A., Khadilkar V.
Source: Bone Abstracts (ICCBH 2019), 2019; 10.1530/boneabs.7.P155: 155
GID: 5124; Last update: 30.05.2020
More information: Original Article

Research Studies (2020)

The Effects of 20 Weeks of Side-Alternating Vibration Therapy on Physical Function, Bone and Muscle Health in Adolescents With Down Syndrome

Aims: To evaluate the effects of side-alternating vibration therapy on physical function and body composition in adolescents with Down syndrome.Methods: Fourteen adolescents (8 males) with Down syndrome (mean weiter...

Author: Silmara Gusso, Renuka M Vesey, José G B Derraik, Craig F Munns, Patricia Colle , Janene B Biggs, Paul L Hofman
Source: Phys Occup Ther Pediatr, 2020; 28: 1-12, PMID: 32345083
Keywords: BMC, Down Syndrome, muscle function, vibration plate
#GRFS169
GID: 5121; Last update: 26.05.2020

Research Studies (2020)

Safety, Feasibility and Efficacy of Side-Alternating Vibration Therapy on Bone and Muscle Health in Children and Adolescents With Musculoskeletal Disorders: A Pilot Trial

Aims: A pilot study was performed to establish the safety, feasibility and efficacy of vibration therapy (VT) on bone and muscle health in children and adolescents with a range of musculoskeletal disorders. M weiter...

Author: Renuka M Vesey , Paul L Hofman , José Gb Derraik, Patrícia Colle, Janene B Biggs, Craig F Munns, Wayne S Cutfield, Silmara Gusso
Source: J Paediatr Child Health, 2020; 56(8): 1257-1262, PMID: 32436612
Keywords: bone; muscle; musculoskeletal disorder; physical function; vibration plate.
GID: 5118; Last update: 26.05.2020

Professional Articles (2020)

Effects of supervised high-intensity resistance and impact training or machine-based isometric training on regional bone geometry and strength in middle-aged and older men with low bone mass: The LIFTMOR-M semi-randomised controlled trial.

INTRODUCTION: Few data exist on the effects of bone-targeted exercise on geometric and biomechanical indices of bone strength in men. The Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation weiter...

Author: Harding AT, Weeks BK, Lambert C, Watson SL, Weis LJ, Beck BR
Source: Bone, 2020; 136: 115263, PMID: 32289518
GID: 5095; Last update: 20.04.2020

Scientific Publications (2020)

25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D, and Peripheral Bone Densitometry in Adults with Celiac Disease.

Background: Adults with celiac disease (CeD) show low bone mineral density (BMD) and high fracture risk. CeD guidelines suggest measurements of serum minerals and vitamin D. However, studies on vitamin levels weiter...

Author: Ciacci C, Bilancio G, Russo I, Iovino P, Cavallo P, Santonicola A, Bucci C, Cirillo M, Zingone F
Source: Nutrients, 2020; 12(4): 929, PMID: 32230847
GID: 5090; Last update: 06.04.2020

Professional Articles (2020)

High Impact Physical Activity and Bone Health of Lower Extremities in Childhood Cancer Survivors: A Cross-sectional Study of SURfit.

Childhood cancer survivors (CCS) are at risk of reduced bone health and premature osteoporosis. As physical activity with high impact loading (IL-PA) is known to promote bone health, we compared bone densitomet weiter...

Author: Zurcher SJ, Jung R, Monnerat S, Schindera C, Eser P, Meier C, Rueegg CS, von der Weid NX, Kriemler S
Source: Int J Cancer, 2020; (): , PMID: 32167159
GID: 5077; Last update: 16.03.2020

Research Studies (2020)

The impact of sensory and/or sensorimotor neuropathy on lower limb muscle endurance, explosive and maximal muscle strength in patients with type 2 diabetes mellitus.

AIMS: The purpose of this study was to investigate the impact of diabetic neuropathy (dNP) on lower limb endurance, explosive and maximal muscle strength in patients with Type 2 Diabetes Mellitus (T2DM). METHOD weiter...

Author: Van Eetvelde BLM, Lapauw B, Proot P, Vanden Wyngaert K, Celie B, Cambier D, Calders P
Source: J Diabetes Complications, 2020; 34(6): 107562, PMID: 32122790
Keywords: Type 2 diabetes mellitus Diabetic neuropathy Maximal muscle strength Muscle endurance Explosive muscle strength
GID: 5079; Last update: 16.03.2020

Research Studies (2020)

Deficits in bone architecture and strength in children living with HIV on antiretroviral therapy.

BACKGROUND: Reduced bone mineral mass by dual x-ray absorptiometry (DXA) is reported in children living with HIV (CLWH), but few studies of bone microarchitecture, particularly in sub-Saharan Africa, have been weiter...

Author: Shiau S, Yin MT, Strehlau R, Burke M, Patel F, Kuhn L, Coovadia A, Norris SA, Arpadi SM
Source: J Acquir Immune Defic Syndr, 2020; 84(1): 101-106, PMID: 32141960
GID: 5070; Last update: 10.03.2020

Research Studies (2020)

Regional changes in indices of bone strength of upper and lower limbs in response to high-intensity impact loading or high-intensity resistance training.

It is well known that the bone response to physical activity is highly dependent on the nature of the loads imposed. Despite this, few direct comparisons of the effect of impact-style loading and resistance tr weiter...

Author: Lambert C, Beck BR, Harding AT, Watson SL, Weeks BK
Source: Bone, 2020; 132(): 115192, PMID: 31846824
GID: 5049; Last update: 27.02.2020

Professional Articles (2020)

Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: The Cardiovascular Risk in Young Finns Study.

BACKGROUND: Studies have shown that osteoporosis and atherosclerosis are comorbid conditions sharing common risk factors and pathophysiological mechanisms. Understanding these is crucial in order to develop sha weiter...

Author: Mishra BH, Mishra PP, Mononen N, Hilvo M, Sievanen H, Juonala M, Laaksonen M, Hutri-Kahonen N, Viikari J, Kahonen M, Raitakari OT, Laaksonen R, Lehtimaki T
Source: Bone, 2020; 131(): 115160, PMID: 31759205
GID: 5050; Last update: 27.02.2020

User Reports (2020)

Bone health in adolescents with idiopathic scoliosis.

AIMS: Idiopathic scoliosis is the most common spinal deformity in adolescents and children. The aetiology of the disease remains unknown. Previous studies have shown a lower bone mineral density in individuals weiter...

Author: Diarbakerli E, Savvides P, Wihlborg A, Abbott A, Bergstrom I, Gerdhem P
Source: Bone Joint J, 2020; 102-B(2): 268-272, PMID: 32009439
GID: 5042; Last update: 11.02.2020

Research Studies (2020)

Self-reported Sleep Quality and Bone Outcomes in Older Adults: Findings from the Hertfordshire Cohort Study.

Sleep duration may be associated with risk of osteoporosis, with suggestions that too little or indeed too much sleep may be detrimental to bone health. In this study, we considered whether perceived sleep qual weiter...

Author: Bevilacqua G, Denison HJ, Laskou F, Jameson KA, Ward KA, Cooper C, Dennison EM
Source: Calcif Tissue Int, 2020; 106(5): 455-464, PMID: 31955228
GID: 5027; Last update: 20.01.2020

Research Studies (2019)

Correlation Between Mechanography and Clinical Parameters at Six Months After Hip Fracture Surgery.

OBJECTIVE: To investigate the correlation between mechanography and clinical parameters in older people at 3 and 6 months after hip fracture surgery. METHODS: A longitudinal follow-up study was conducted in uni weiter...

Author: Min TJ, Cho J, Ha YC, Lim JY, Kang SH, Kim DK, Seo KM, Beom J
Source: Ann Rehabil Med, 2019; 43(6): 642-649, PMID: 31918527
GID: 5029; Last update: 20.01.2020

Research Studies (2020)

Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography.

We investigated the relationship between lower limb osteoarthritis (OA) and muscle strength and power (assessed by jumping mechanography) in UK community-dwelling older adults. We recruited 249 older adults (14 weiter...

Author: Shere C, Fuggle NR, Edward MH, Parsons CM, Jameson KA, Cooper C, Dennison EM, Ward KA
Source: Calcif Tissue Int, 2020; 106(2): 115-123, PMID: 31655874
Keywords: Osteoarthritis
GID: 5031; Last update: 20.01.2020
More information: Original Article

Research Studies (2019)

Normative-referenced percentile values for physical fitness among Canadians.

BACKGROUND: This study developed age- and sex-specific normative-referenced percentile values for five physical fitness tests across a wide age range of Canadians, using a nationally representative sample. DATA weiter...

Author: Hoffmann MD, Colley RC, Doyon CY, Wong SL, Tomkinson GR, Lang JJ
Source: Health Rep, 2019; 30(10): 14-22, PMID: 31617933
GID: 5032; Last update: 20.01.2020
More information: Original Article

Research Studies (2020)

Feasibility and Effects on Muscle Function of an Exercise Program for Older Adults.

INTRODUCTION: Study objective was to determine feasibility and compliance with a 3-month exercise intervention in older adults, and if peripheral quantitative computed tomography muscle measures and jumping me weiter...

Author: Minett MM, Binkley TL, Holm RP, Runge M, Specker BL
Source: Med Sci Sports Exerc, 2020; 52(2): 441-448, PMID: 31939912
GID: 5028; Last update: 20.01.2020

Research Studies (2019)

BIA-assessed cellular hydration and muscle performance in youth, adults, and older adults.

BACKGROUND & AIMS: Alterations in body hydration can have an impact on muscle performance, with consequences not only at a sporting level, but on overall health and daily functional competence. Given that t weiter...

Author: Hetherington-Rauth M, Baptista F, Sardinha LB
Source: Clin Nutr, 2019; 39(8): 2624-2630, PMID: 31837838
GID: 5030; Last update: 20.01.2020

Research Studies (2020)

Effects of Whole-Body Vibration Training and Blood Flow Restriction on Muscle Adaptations in Women: A Randomized Controlled Trial.

Centner, C, Ritzmann, R, Gollhofer, A, and Konig, D. Effects of whole-body vibration training and blood flow restriction on muscle adaptations in women: a randomized controlled trial. J Strength Cond Res XX(X): weiter...

Author: Centner C, Ritzmann R, Gollhofer A, Konig D
Source: J Strength Cond Res, 2020; 34(3): 603-608, PMID: 31842133
GID: 5014; Last update: 14.01.2020

Research Studies (2020)

Higher fracture prevalence and smaller bone size in patients with hEDS/HSD-a prospective cohort study.

Increased fracture risk in patients with Ehlers-Danlos syndromes has been reported, but the reasons for it are incompletely understood. We aimed to investigate possible determinants of this increased risk and f weiter...

Author: Banica T, Coussens M, Verroken C, Calders P, De Wandele I, Malfait F, Zmierczak HG, Goemaere S, Lapauw B, Rombaut L
Source: Osteoporos Int, 2020; 31(5): 849-856, PMID: 31873762
GID: 5018; Last update: 14.01.2020

Research Studies (2020)

Balance Performance across the Lifespan Assessed by the Leonardo Mechanograph®: A Cross-Sectional Study

Reference values of sway parameters have not been published for the Leonardo mechanograph® so far. The aim of this cross-sectional study was to determine normative values on postural control measured by the fo weiter...

Author: Wiegmann S, Felsenberg D, Gast U, Börst H, Armbrecht G, Dietzel R
Source: J. Funct. Morphol. Kinesiol., 2020; 5(1): doi:10.3390/jfmk5010, PMID: 33467217
Keywords: Balance
GID: 5007; Last update: 20.12.2019
More information: Original Article

Scientific Publications (2019)

Forearm bone density, cross-sectional size and muscle cross-sectional area in adolescents with diabetes mellitus type 1 assessed by peripheral quantitative computed tomography.

OBJECTIVES: The mechanical components of bone strength (size, shape and density) in adolescents with T1DM are not extensively studied. METHODS: The studied group comprises 39 adolescents, aged 11,9-18,0 yrs. weiter...

Author: Jaworski M, Wierzbicka E, Pludowski P, Szalecki M
Source: J Musculoskelet Neuronal Interact, 2019; 19(4): 435-447, PMID: 31789294
GID: 5004; Last update: 09.12.2019

Scientific Publications (2020)

Bone health in women with a history of gestational diabetes or obesity.

INTRODUCTION: Type 2 diabetes is associated with an increased risk of bone fractures. However, bone health of women with a history of gestational diabetes (GDM) has received little attention. This cross-section weiter...

Author: Engberg E, Koivusalo SB, Huvinen E, Viljakainen H
Source: Acta Obstet Gynecol Scand, 2020; 99 (4): 477-487, PMID: 31784976
GID: 5000; Last update: 02.12.2019

Scientific Publications (2020)

Muscle and bone parameters in underprivileged Indian children and adolescents with T1DM.

BACKGROUND: The incidence of Type 1 diabetes mellitus (T1DM) is increasing and sarcopenia and osteoporosis have been reported to be associated with long standing diabetes. There is scarcity of data on bone heal weiter...

Author: Dongare-Bhor S, Lohiya N, Maheshwari A, Ekbote V, Chiplonkar S, Padidela R, Mughal Z, Khadilkar V, Khadilkar A
Source: Bone, 2020; 130: 115074, PMID: 31626994
GID: 4996; Last update: 19.11.2019

Scientific Publications (2020)

Peripheral quantitative computed tomography (pQCT)-based finite element analysis provides enhanced diagnostic performance in identifying non-vertebral fracture patients compared with dual-energy X-ray absorptiometry.

Due to limitations of the predominant clinical method for diagnosing osteoporosis, an engineering model based on a dedicated CT scanner for bone density and structure was applied in fracture patients and contro weiter...

Author: Jiang H, Robinson DL, Yates CJ, Lee PVS, Wark JD
Source: Osteoporos Int, 2020; 31(1): 141-151, PMID: 31720708
GID: 4990; Last update: 19.11.2019

Fundamental Studies (2020)

Bone Marrow and Muscle Fat Infiltration are Correlated Among Postmenopausal Women with Osteoporosis: the AMBERS Cohort Study.

Bone and muscle have shown to interact, but little is known about fat within bone and muscle. Clinical studies have isolated fat within bone and muscle using MRI. In this cross-sectional study, we hypothesized weiter...

Author: Wong AK, Chandrakumar A, Whyte R, Reitsma S, Gillick H, Pokhoy A, Papaioannou A, Adachi JD
Source: J Bone Miner Res, 2020; 35(3): 516-527, PMID: 31675452
GID: 4995; Last update: 19.11.2019

Scientific Publications (2019)

Bone Mass and Strength and Fall-Related Fractures in Older Age.

Introduction: Low bone mineral density is a risk factor for fractures. The aim of this follow-up study was to assess the association of various bone properties with fall-related fractures. Materials and Methods weiter...

Author: Uusi-Rasi K, Karinkanta S, Tokola K, Kannus P, Sievanen H
Source: J Osteoporos, 2019; 2019: 5134690, PMID: 31583071
GID: 4979; Last update: 14.10.2019

Professional Articles (2020)

Bone geometry and lower extremity bone stress injuries in male runners.

Bone stress injuries (BSI) are common among distance runners and research investigations examining risk factors for BSI among men are limited. Therefore, investigations are needed to determine if men with a his weiter...

Author: Popp KL, Frye AC, Stovitz SD, Hughes JM
Source: J Sci Med Sport, 2020; 23(2): 145-150, PMID: 31594711
GID: 4984; Last update: 14.10.2019

Fundamental Studies (2020)

A rare mutation in SMAD9 associated with high bone mass identifies the SMAD-dependent BMP signalling pathway as a potential anabolic target for osteoporosis.

Novel anabolic drug targets are needed to treat osteoporosis. Having established a large national cohort with unexplained high bone mass (HBM), we aimed to identify a novel monogenic cause of HBM and provide i weiter...

Author: Gregson CL, Bergen D, Leo P, Sessions RB, Wheeler L, Hartley A, Youlten S, Croucher PI, McInerney-Leo AM, Fraser W, Tang JCY, Anderson L, Marshall M, Sergot L, Paternoster L, Davey-Smith G, Brown MA, Hammond C, Kemp JP, Tobias JH, Duncan EL
Source: J Bone Miner Res, 2020; 35(1): 92-105, PMID: 31525280
GID: 4977; Last update: 26.09.2019

Research Studies (2020)

The acute effects of different frequencies of whole-body vibration on arterial stiffness.

Whole-body vibration (WBV) can decrease arterial stiffness, but the effects of low-frequency WBV on arterial stiffness are not known. The aim of this study was to clarify the acute effects on arterial stiffnes weiter...

Author: Kim E, Okamoto T, Song J, Lee K
Source: Clin Exp Hypertens, 2020; 42(4): 345-351, PMID: 31514544
GID: 4964; Last update: 16.09.2019

Scientific Publications (2019)

Predicting experimentally-derived failure load at the distal radius using finite element modelling based on peripheral quantitative computed tomography cross sections (pQCT-FE): A validation study.

Dual energy X-ray absorptiometry, the current clinical criterion method for osteoporosis diagnosis, has limitations in identifying individuals with increased fracture risk, especially at the distal radius. Peri weiter...

Author: Jiang H, Robinson DL, McDonald M, Lee PVS, Kontulainen SA, Johnston JD, Yates CJ, Wark JD
Source: Bone, 2019; 129: 115051, PMID: 31472298
GID: 4960; Last update: 02.09.2019

Scientific Publications (2020)

Effect of rheumatoid arthritis and age on metacarpal bone shaft geometry and density: A longitudinal pQCT study in postmenopausal women.

OBJECTIVE: This study aimed to elucidate the effects of changes in the geometry and density of the metacarpal bone of patients with rheumatoid arthritis (RA). METHODS: This prospective study included consecutiv weiter...

Author: Aeberli D, Fankhauser N, Zebaze R, Bonel H, Moller B, Villiger PM
Source: Semin Arthritis Rheum, 2020; 50(2): 220-227, PMID: 31466837
GID: 4961; Last update: 02.09.2019

Research Studies (2019)

Effects of a Home-Based Physical Rehabilitation Program on Tibial Bone Structure, Density, and Strength After Hip Fracture: A Secondary Analysis of a Randomized Controlled Trial.

Weight-bearing physical activity may decrease or prevent bone deterioration after hip fracture. This study investigated the effects of a home-based physical rehabilitation program on tibial bone traits in older weiter...

Author: Suominen TH, Edgren J, Salpakoski A, Arkela M, Kallinen M, Cervinka T, Rantalainen T, Tormakangas T, Heinonen A, Sipila S
Source: JBMR Plus, 2019; 3(6): e10175, PMID: 31346568
GID: 4946; Last update: 20.08.2019

Professional Articles (2019)

pQCT bone geometry and strength: population epidemiology and concordance in Australian children aged 11-12 years and their parents.

OBJECTIVES: To describe the epidemiology and concordance of bone health in a population-based sample of Australian parent-child dyads at child age 11-12 years. DESIGN: Population-based cross-sectional study (th weiter...

Author: Vlok J, Simm PJ, Lycett K, Clifford SA, Grobler AC, Lange K, Ismail N, Osborn W, Wake M
Source: BMJ Open, 2019; 9(Suppl 3): 63-74, PMID: 31273017
GID: 4939; Last update: 08.07.2019

Scientific Publications (2019)

Impact of Adrenal Hormone Supplementation on Bone Geometry in Growing Teens With Anorexia Nervosa.

PURPOSE: Adolescents with anorexia nervosa (AN) have decreased dehydroepiandrosterone (DHEA) and estrogen concentrations that may contribute to skeletal deficits. We sought to determine whether DHEA + estrogen weiter...

Author: DiVasta AD, Feldman HA, O"Donnell JM, Long J, Leonard MB, Gordon CM
Source: J Adolesc Health, 2019; 65(4): 462-468, PMID: 31227390
GID: 4933; Last update: 01.07.2019

Scientific Publications (2019)

Pentosidine Is Associated With Cortical Bone Geometry and Insulin Resistance in Otherwise Healthy Children.

Pentosidine is an advanced glycation end product (AGE) associated with fracture in adults with diabetes. AGE accumulation in bone collagen contributes to bone fragility but might also adversely influence bone t weiter...

Author: Kindler JM, Laing EM, Liu W, Dain JA, Lewis RD
Source: J Bone Miner Res, 2019; 34(8): 1446-1450, PMID: 31220375
GID: 4934; Last update: 01.07.2019

Research Studies (2019)

A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease.

End stage renal disease (ESRD) is associated with sarcopenia and skeletal fragility. The objectives of this cross-sectional study were to (1) characterize body composition, bone mineral density (BMD) and bone weiter...

Author: Leonard MB, Wehrli FW, Ziolkowski SL, Billig E, Long J, Nickolas TL, Magland JF, Nihtianova S, Zemel BS, Herskovitz R, Rajapakse CS
Source: Bone, 2019; 127(): 271-279, PMID: 31158505
GID: 4917; Last update: 17.06.2019

Scientific Publications (2019)

Bone mineral density, structure, distribution and strength in men with prostate cancer treated with androgen deprivation therapy.

Androgen deprivation therapy (ADT) improves survival in men with advanced prostate cancer (PCa), but has been associated with compromised skeletal health and increased fracture risk. However, limited previous r weiter...

Author: Via JD, Daly RM, Owen PJ, Mundell NL, Rantalainen T, Fraser SF
Source: Bone, 2019; 127(): 367-375, PMID: 31189088
GID: 4926; Last update: 17.06.2019

Scientific Publications (2019)

Dietary inflammatory index® and cortical bone outcomes in healthy adolescent children.

Diet is thought to modulate inflammation. This study shows no relationships between the dietary inflammatory index (DII) and biomarkers of inflammation or bone after adjusting for covariates. Monocyte chemoattr weiter...

Author: Coheley LM, Shivappa N, Hebert JR, Lewis RD
Source: Osteoporos Int, 2019; 30(8): 1645-1654, PMID: 31143990
GID: 4912; Last update: 03.06.2019

Research Studies (2015)

Age-Related Loss of Muscle Mass, Strength, and Power and Their Association With Mobility in Recreationally-Active Older Adults in the United Kingdom.

To investigate reasons for the age-related reduction in physical function, we determined the relationships between muscle size, strength, and power with 6-min walk distance (6MWD) and timed up-and-go performan weiter...

Author: Maden-Wilkinson TM, McPhee JS, Jones DA, Degens H
Source: J Aging Phys Act, 2015; 23(3): 352-60, PMID: 25007824
GID: 4905; Last update: 21.05.2019
More information: Original Article

Research Studies (2020)

Testing the deconditioning hypothesis of low back pain: A study in 1182 older women.

This study assessed the deconditioning hypothesis of low back pain (LBP) by examining physical function in relation to LBP and self-reported physical activity in women. This cross-sectional study recruited a re weiter...

Author: Tagliaferri SD, Armbrecht G, Miller CT, Owen PJ, Mundell NL, Felsenberg D, Thomasius F, Belavy DL
Source: Eur J Sport Sci, 2020; 20(1): 17-23, PMID: 31012382
GID: 4899; Last update: 29.04.2019

Scientific Publications (2019)

Breech presentation is associated with lower adolescent tibial bone strength.

We compared bone outcomes in adolescents with breech and cephalic presentation. Tibia bone mineral content, density, periosteal circumference, and cross-sectional moment of inertia were lower in breech presenta weiter...

Author: Tobias JH, Sayers A, Deere KC, Heazell AEP, Lawlor DA, Ireland A
Source: Osteoporos Int, 2019; 30(7): 1423-1432, PMID: 31020365
GID: 4895; Last update: 26.04.2019

Research Studies (2019)

Whole-body vibration impedes the deterioration of postural control in patients with multiple sclerosis.

OBJECTIVE: The current study aimed to investigate if whole-body vibration (WBV) might attenuate the processing functional and neuromuscular degeneration of postural control in patients with MS. DESIGN: Performa weiter...

Author: Krause A, Lee K, Freyler K, Buhrer T, Gollhofer A, Ritzmann R
Source: Mult Scler Relat Disord, 2019; 31: 134-140, PMID: 30991299
GID: 4893; Last update: 23.04.2019

Research Studies (2019)

Type 1 diabetes onset at young age is associated with compromised bone quality.

Women with type 1 diabetes (T1D) are at increased risk for fracture. We studied the association of T1D and young age at T1D onset (T1D onset before 20years) on bone structural quality. 24 postmenopausal women w weiter...

Author: Shah VN, Joshee P, Sippl R, Pyle L, Vigers T, Carpenter D, Kohrt W, Snell-Bergeon JK
Source: Bone, 2019; 123(): 260-264, PMID: 30936041
GID: 4887; Last update: 08.04.2019

Research Studies (2019)

Adherence to a Mediterranean Diet and Bone Mineral Density in Spanish Premenopausal Women.

The Mediterranean diet (MD) has been associated with an improvement in health and an increase in longevity. Certain components of a MD can play a role in the prevention of osteoporosis and/or hip fracture. We i weiter...

Author: Perez-Rey J, Roncero-Martin R, Rico-Martin S, Rey-Sanchez P, Pedrera-Zamorano JD, Pedrera-Canal M, Lopez-Espuela F, Lavado Garcia JM
Source: Nutrients, 2019; 11(3): 555, PMID: 30841631
GID: 4871; Last update: 11.03.2019
More information: Original Article

Research Studies (2019)

Lean mass and lower limb muscle function in relation to hip strength, geometry and fracture risk indices in community-dwelling older women.

In a population-based sample of British women aged over 70 years old, lean mass and peak lower limb muscle force were both independently associated with hip strength and fracture risk indices, thereby suggestin weiter...

Author: Elhakeem A, Hartley A, Luo Y, Goertzen AL, Hannam K, Clark EM, Leslie WD, Tobias JH
Source: Osteoporos Int, 2019; 30(1): 211-220, PMID: 30552442
Keywords: Leonardo, BMD Femoral Neck
GID: 4873; Last update: 11.03.2019
More information: Original Article

Research Studies (2018)

Feasibility and safety of a 6-month exercise program to increase bone and muscle strength in children with juvenile idiopathic arthritis.

BACKGROUND: Arthritis in childhood can be associated with muscle weakness around affected joints, low bone mass and low bone strength. Exercise is recognized as an important part of management of children with weiter...

Author: Houghton KM, Macdonald HM, McKay HA, Guzman J, Duffy C, Tucker L
Source: Pediatr Rheumatol Online J, 2018; 16(1): 67, PMID: 30348221
GID: 4874; Last update: 11.03.2019
More information: Original Article

Research Studies (2019)

Evaluation of long-term functional donor-site morbidity after deep circumflex iliac crest artery bone flap harvest.

PURPOSE: Free flap surgery can be associated with donor-site morbidity. The purpose of this study was to analyze long-term functional outcomes at the donor site after deep circumflex iliac artery (DCIA) bone fl weiter...

Author: Rendenbach C, Goehler F, Hansen L, Kohlmeier C, Amling M, Hanken H, Beck-Broichsitter B, Heiland M, Riecke B
Source: Microsurgery, 2019; 39(4): 304-309, PMID: 30159928
GID: 4877; Last update: 11.03.2019

Scientific Publications (2019)

Long-term Outcomes of Adolescent Anorexia Nervosa on Bone.

PURPOSE: Anorexia nervosa (AN) is a chronic and life-threatening eating disorder that can have a considerable negative impact on the growing skeleton. We hypothesized that the long-term impact on bone health m weiter...

Author: Mumford J, Kohn M, Briody J, Miskovic-Wheatley J, Madden S, Clarke S, Biggin A, Schindeler A, Munns C
Source: J Adolesc Health, 2019; 64(3): 305-310, PMID: 30819332
GID: 4867; Last update: 04.03.2019

Research Studies (2019)

Application of current sarcopenia definitions in spinal cord injury

Objective: Little is known about how appropriate the working definitions of sarcopenia are in subjects with spinal cord injury (SCI). This study aimed to evaluate the application of current sarcopenia definitio weiter...

Author: Yannis Dionyssiotis, Grigorios Skarantavos, Konstantina Petropoulou, Antonios Galanos,Christina-Anastassia Rapidi, George P. Lyritis
Source: J Musculoskelet Neuronal Interact, 2019; 1(19): 21-29, PMID: 30839300
Keywords: Sarcopenia, Spinal Cord Injury, Cross Sectional Muscle Area, pQCT, Whole Body DXA
GID: 4865; Last update: 28.02.2019

Professional Articles (2019)

Sex-specific associations between insulin resistance and bone parameters in overweight and obese older adults.

OBJECTIVES: To determine sex-specific associations between insulin resistance and bone parameters measured by peripheral quantitative computed tomography (pQCT) in overweight and obese community-dwelling older weiter...

Author: Mesinovic J, McMillan LB, Shore-Lorenti C, Zengin A, De Courten B, Ebeling PR, Scott D
Source: Clin Endocrinol (Oxf), 2019; 90(5): 680-689, PMID: 30724369
GID: 4853; Last update: 13.02.2019

Research Studies (2019)

Childhood exposure to passive smoking and bone health in adulthood. The Cardiovascular Risk in Young Finns Study.

Context: Passive smoke exposure has been linked with the risk of osteoporosis in adults. Objective: We aimed to examine the independent effects of exposure to passive smoking in childhood on adult bone health. weiter...

Author: Juonala M, Pitkanen N, Tolonen S, Laaksonen M, Sievanen H, Jokinen E, Laitinen T, Sabin MA, Hutri-Kahonen N, Lehtimaki T, Taittonen L, Jula A, Loo BM, Impivaara O, Kahonen M, Magnussen CG, Viikari JSA, Raitakari OT
Source: J Clin Endocrinol Metab, 2019; 104(6): 2403-2411, PMID: 30715377
GID: 4854; Last update: 13.02.2019

Research Studies (2019)

Acute Neuromuscular Modulation Enhances Postural Control after Whole-Body Vibration

The postural movement control determines performance of almost any kind of human movement. The current study aimed to investigate whether a short bout of whole-body vibration (WBV) can improve postural control. weiter...

Author: Krause A, Ritzmann R, Lee K, Freyler K, Gollhofer A
Source: GERMAN JOURNAL OF SPORTS MEDICINE, 2019; 70(1): 5-12
Keywords: Postural Control, Balance, Leonardo
#GRFS158
GID: 4838; Last update: 05.02.2019
More information: Original Article

Research Studies (2019)

Glucocorticoids and body fat inversely associate with bone marrow density of the distal radius in healthy youths

Background Elevated bone marrow adipose tissue (BMAT) is associated with lower bone quality, higher fracture rates, and an unfavorable overall metabolic profile. Apart from older age, particularly glucocortico weiter...

Author: Jonas Esche Lijie Shi Michaela F Hartmann Eckhard Schönau Stefan A Wudy Thomas Remer
Source: The Journal of Clinical Endocrinology & Metabolism, jc., 2019; 104(6): 2250-2256, PMID: 30715368
GID: 4841; Last update: 05.02.2019

Research Studies (2018)

Bone changes in the lower limbs from participation in an FES rowing exercise program implemented within two years after traumatic spinal cord injury.

OBJECTIVE: To determine the effect of a functional electrical stimulation (FES) rowing program on bone mineral density (BMD) when implemented within two years after SCI. DESIGN: Prospective. SETTING: Health Car weiter...

Author: Lambach RL, Stafford NE, Kolesar JA, Kiratli BJ, Creasey GH, Gibbons RS, Andrews BJ, Beaupre GS
Source: J Spinal Cord Med, 2018; 26(): 1-9, PMID: 30475172
GID: 4808; Last update: 03.12.2018

Scientific Publications (2018)

Assessment of Bone and Muscle Measurements by Peripheral Quantitative Computed Tomography in Geriatric Patients.

The loss of bone and muscle mass increases the risk of osteoporotic fractures. Dual energy X-ray absorptiometry (DXA) loses sensitivity in older age. The purpose of this study was to evaluate bone and muscle me weiter...

Author: Drey M, Henkel M, Petermeise S, Weiss S, Ferrari U, Rottenkolber M, Schmidmaier R
Source: J Clin Densitom, 2018; (): , PMID: 30425007
GID: 4803; Last update: 19.11.2018

Research Studies (2018)

Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies - a randomized controlled pilot study.

BACKGROUND: Hospitalized cancer patients undergoing intensive or high-dose chemotherapy often experience a considerable decline in functional performance associated with the increased risk of adverse health eve weiter...

Author: Pahl A, Wehrle A, Kneis S, Gollhofer A, Bertz H
Source: BMC Cancer, 2018; 18(920): , PMID: 30253746
Keywords: Onkologoie, Cancer, ChemoTherapy
#GRFS158
GID: 4774; Last update: 15.10.2018
More information: Original Article

Scientific Publications (2019)

The application of finite element modelling based on clinical pQCT for classification of fracture status.

Fracture risk assessment using dual-energy X-ray absorptiometry (DXA) frequently fails to diagnose osteoporosis amongst individuals who later experience fragility fractures. Hence, more reliable techniques tha weiter...

Author: Robinson DL, Jiang H, Song Q, Yates C, Lee PVS, Wark JD
Source: Biomech Model Mechanobiol, 2019; 18(1): 245-260, PMID: 30293203
GID: 4773; Last update: 15.10.2018

Research Studies (2018)

Associations of fluoride intake with children"s cortical bone mineral and strength measures at age 11.

OBJECTIVES: There is strong affinity between fluoride and calcium, and mineralized tissues. Investigations of fluoride and bone health during childhood and adolescence show inconsistent results. This analysis weiter...

Author: Levy SM, Eichenberger-Gilmore JM, Warren JJ, Kavand G, Letuchy E, Broffitt B, Marshall TA, Burns TL, Janz KF, Pauley C, Torner JC, Phipps K
Source: J Public Health Dent, 2018; 78(4): 352-359, PMID: 30155933
GID: 4750; Last update: 03.09.2018

Research Studies (2018)

Growth, bone health & ambulatory status of boys with DMD treated with daily vs. intermittent oral glucocorticoid regimen.

Oral glucocorticoids (GC) preserve muscle strength and prolong walking in boys with Duchenne muscular dystrophy (DMD). Although vertebral fractures have been reported in boys taking GC, fracture rates for diffe weiter...

Author: Crabtree NJ, Adams JE, Padidela R, Shaw NJ, Hogler W, Roper H, Hughes I, Daniel A, Mughal MZ
Source: Bone, 2018; 116(): 181-186, PMID: 30055340
GID: 4746; Last update: 29.08.2018

Research Studies (2018)

Circum-menarcheal bone acquisition is stress-driven: A longitudinal study in adolescent female gymnasts and non-gymnasts.

Mechanical loading through youth exercise is highly modifiable and represents a strategy to maximize peak adult bone mass, with the potential for broad implementation across the population to lower fracture ris weiter...

Author: Troy KL, Scerpella TA, Dowthwaite JN
Source: J Biomech, 2018; 78(): 45-51, PMID: 30055842
GID: 4745; Last update: 29.08.2018

Research Studies (2018)

Persistence of muscle-bone deficits following anti-tumor necrosis factor therapy in adolescents with crohn"s disease.

OBJECTIVES: To assess change in the muscle-bone unit in adolescents with Crohn"s disease (CD) on anti-tumor necrosis factor (anti-TNFalpha). METHODS: Prospective study following anti-TNFalpha in 19 adolescent weiter...

Author: Altowati MMA, Shepherd S, McMillan M, McGrogan P, Russell R, Ahmed SF, Wong SC
Source: J Pediatr Gastroenterol Nutr, 2018; 67(6): 738-744, PMID: 30052566
GID: 4747; Last update: 29.08.2018

Scientific Publications (2018)

Suboptimal bone status for adolescents with low motor competence and developmental coordination disorder-It"s sex specific.

BACKGROUND: Australian adolescents with low motor competence (LMC) have higher fracture rates and poorer bone health compared to European normative data, but currently no normative data exists for Australians. weiter...

Author: Chivers P, Rantalainen T, McIntyre F, Hands B, Weeks B, Beck B, Sophia N, Hart N, Siafarikas A
Source: Res Dev Disabil, 2018; S0891-4222(18): 30179-3, PMID: 30119956
GID: 4738; Last update: 21.08.2018

Research Studies (2018)

Low physical performance determined by chair rising test muscle mechanography is associated with prevalent fragility fractures.

This study examined associations between physical performance assessed by chair rising test muscle mechanography and DXA T-score as well as body composition in a large patient cohort. Next to various significan weiter...

Author: Rupp T, Butscheidt S, Jahn K, Simon MJ, Mussawy H, Oheim R, Barvencik F, Amling M, Rolvien T
Source: Arch Osteoporos, 2018; 13(1): 71, PMID: 29968169
GID: 4735; Last update: 24.07.2018

Scientific Publications (2018)

Changes in bone microarchitecture following kidney transplantation - beyond bone mineral density.

Bone disease in kidney transplant recipients (KTRs) is characterised by bone mineral density (BMD) loss but bone microarchitecture changes are poorly defined. In this prospective cohort study, we evaluated bone weiter...

Author: Sharma AK, Toussaint ND, Elder GJ, Rajapakse CS, Holt SG, Baldock P, Robertson PL, Ebeling PR, Sorci OR, Masterson R
Source: Clin Transplant, 2018; 32(9): e13347, PMID: 29984421
GID: 4726; Last update: 16.07.2018

Research Studies (2018)

Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study.

OBJECTIVE: To investigate the associations between period-specific and cumulative fluoride (F) intakes from birth to age 17 years, and radial and tibial bone measures obtained using peripheral quantitative comp weiter...

Author: Oweis RR, Levy SM, Eichenberger-Gilmore JM, Warren JJ, Burns TL, Janz KF, Torner JC, Saha PK, Letuchy E
Source: Community Dent Oral Epidemiol, 2018; 46(6): 527-534, PMID: 29962091
GID: 4724; Last update: 09.07.2018

Research Studies (2018)

Diagnosis of Recurrent Fracture in a Pediatric Cohort.

Significant fracture history in children is defined as having at least one vertebral fracture, at least 2 fractures by age 10, or at least 3 fractures by age 19. Between September 2011 and December 2014, clinic weiter...

Author: Fiscaletti M, Coorey CP, Biggin A, Briody J, Little DG, Schindeler A, Munns CF
Source: Calcif Tissue Int, 2018; 103(5): 529-539, PMID: 29943187
GID: 4709; Last update: 02.07.2018

Research Studies (2018)

Diet Quality and Bone Measurements Using HRpQCT and pQCT in Older Community-Dwelling Adults from the Hertfordshire Cohort Study.

There are few data describing associations between dietary patterns and bone microarchitecture. This study investigated the relationship between diet quality and HRpQCT and pQCT measures in older adults. Data weiter...

Author: Shaw SC, Parsons CM, Fuggle NR, Edwards MH, Robinson SM, Dennison EM, Cooper C, Ward KA
Source: Calcif Tissue Int, 2018; 103(5): 494-500, PMID: 29931462
GID: 4700; Last update: 25.06.2018

Research Studies (2018)

Longitudinal Change in Peripheral Quantitative Computed Tomography Assessment in Older Adults: The Hertfordshire Cohort Study.

There are few longitudinal data on change in bone structure and muscle mass, strength and function in later life. We report these, and consider bone-muscle interrelationships in older men and women. We studied weiter...

Author: Patel A, Edwards MH, Jameson KA, Ward KA, Fuggle N, Cooper C, Dennison EM
Source: Calcif Tissue Int, 2018; 103(): 476-482, PMID: 29931460
GID: 4701; Last update: 25.06.2018

Scientific Publications (2018)

Could bioelectric impedance spectroscopy (BIS) measured appendicular intracellular water serve as a lean mass measurement in sarcopenia definitions? A pilot study.

DXA lean mass measurement for sarcopenia diagnosis is not always possible. Bioelectric impedance spectroscopy (BIS), a portable technology, is a potential alternative to DXA-measured lean mass. This pilot study weiter...

Author: Siglinsky E, Buehring B, Krueger D, Binkley N, Yamada Y
Source: Osteoporos Int, 2018; 29(7): 1653-1657, PMID: 29574521
GID: 4662; Last update: 13.04.2018

Scientific Publications (2018)

Physical activity, but not sedentary time, influences bone strength in late adolescence.

Physical activity is essential for optimal bone strength accrual, but we know little about interactions between physical activity, sedentary time, and bone outcomes in older adolescents. Physical activity (by a weiter...

Author: Tan VP, Macdonald HM, Gabel L, McKay HA
Source: Arch Osteoporos, 2018; 13(1): 31, PMID: 29556801
GID: 4653; Last update: 22.03.2018

Research Studies (2018)

Sarcopenia is negatively related to high gravitational impacts achieved from day-to-day physical activity.

Background: Sarcopenia has been associated with reduced physical activity (PA). We aimed to determine if sarcopenia, and specific components of muscle size, function and physical performance, are associated wit weiter...

Author: Hartley A, Gregson CL, Hannam K, Deere KC, Clark EM, Tobias JH
Source: J Gerontol A Biol Sci Med Sci, 2018; 73(5): 652-659, PMID: 29182712
Keywords: Muscle function, Physical capability, Accelerometer, G-force, COSHIBA
GID: 4631; Last update: 27.02.2018
More information: Original Article

Research Studies (2017)

Peripheral quantitative computed tomography detects differences at the radius in prepubertal children with cystic fibrosis compared to healthy controls.

INTRODUCTION: In 2015, 11.9% of people with cystic fibrosis (CF) in the United States had osteopenia, 5.1% osteoporosis, and 0.3% experienced a fracture. Screening for CF-related bone disease starts in childhoo weiter...

Author: O"Brien CE, Com G, Fowlkes J, Tang X, James LP
Source: PLoS One, 2017; 13(1): e0191013, PMID: 29324908
GID: 4614; Last update: 22.01.2018

Research Studies (2018)

Increases in IGF-1 after Anti-TNF-alpha Therapy are Associated with Bone and Muscle Accrual in Pediatric Crohn"s Disease.

Context: Low levels of IGF-1 in pediatric and adolescent Crohn"s Disease (CD) likely contribute to bone and muscle deficits. Objective: Assess changes in IGF-1 levels and associations with bone and muscle accru weiter...

Author: DeBoer MD, Lee AM, Herbert K, Long J, Thayu M, Griffin LM, Baldassano RN, Denson LA, Zemel BS, Denburg MR, Herskovitz R, Leonard MB
Source: J Clin Endocrinol Metab, 2018; 103(3): 936–945, PMID: 29329430
GID: 4613; Last update: 22.01.2018

Research Studies (2018)

The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced peripheral neuropathies - STOP.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients weiter...

Author: Streckmann F, Balke M, Lehmann HC, Rustler V, Koliamitra C, Elter T, Hallek M, Leitzmann M, Steinmetz T, Heinen P, Baumann FT, Bloch W
Source: BMC Cancer, 2018; 18(1): 62, PMID: 29316888
Keywords: Chemotherapy, Neuropathy
GID: 4580; Last update: 14.01.2018
More information: Original Article

Scientific Publications (2017)

Dietary Intake of Cadmium, Lead and Mercury and Its Association with Bone Health in Healthy Premenopausal Women.

The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to frac weiter...

Author: Lavado-Garcia JM, Puerto-Parejo LM, Roncero-Martin R, Moran JM, Pedrera-Zamorano JD, Aliaga IJ, Leal-Hernandez O, Canal-Macias ML
Source: Int J Environ Res Public Health, 2017; 14(12): 924-933, PMID: 29168740
Keywords: heavy metals; food; dietary intake; bone health; women’s health; premenopause; bone mineral density
GID: 4567; Last update: 28.11.2017

Research Studies (2017)

Long-term effects of maternal calcium supplementation on childhood growth differ between males and females in a population accustomed to a low calcium intake.

The importance of adequate calcium intakes for healthy growth and bone development has long been recognised. Recent evidence suggests that calcium supplementation may have sex-specific effects on bone growth in weiter...

Author: Ward KA, Jarjou L, Prentice A
Source: Bone, 2017; 103(): 31-38, PMID: 28583879
GID: 4556; Last update: 15.11.2017

Research Studies (2018)

Whole body vibration added to treatment as usual is effective in adolescents with depression: a partly randomized, three-armed clinical trial in inpatients.

There is growing evidence for the effectiveness of exercise in the treatment of adult major depression. With regard to adolescents, clinical trials are scarce. Due to the inherent symptoms of depression (lack o weiter...

Author: Wunram HL, Hamacher S, Hellmich M, Volk M, Janicke F, Reinhard F, Bloch W, Zimmer P, Graf C, Schonau E, Lehmkuhl G, Bender S, Fricke O
Source: Eur Child Adolesc Psychiatry, 2018; 27(5): 645-662, PMID: 29119301
Keywords: UniReha, Cologne Concept, Depression
GID: 4552; Last update: 14.11.2017

Fundamental Studies (2017)

How to prevent the detrimental effects of two months of bed-rest on muscle, bone and cardiovascular system: an RCT.

Physical inactivity leads to a deconditioning of the skeletal, neuromuscular and cardiovascular system. It can lead to impaired quality of life, loss of autonomy, falls and fractures. Regular exercise would be weiter...

Author: Kramer A, Gollhofer A, Armbrecht G, Felsenberg D, Gruber M
Source: Sci Rep, 2017; 7(1): 13177, PMID: 29030644
Keywords: leonardo Jumping Table, BedRest
GID: 4555; Last update: 14.11.2017

Research Studies (2017)

Whole-Body Vibration Combined with Treadmill Training Improves Walking Performance in Post-Stroke Patients: A Randomized Controlled Trial.

BACKGROUND Stroke is characterized by an asymmetrical gait pattern that causes poor stability and reduces overall activity levels. The aim of this study was to investigate the effect of whole-body vibration co weiter...

Author: Choi W, Han D, Kim J, Lee S
Source: Med Sci Monit, 2017; 23(): 4918-4925, PMID: 29031023
Keywords: Stroke, Gait Parameters, Muscle Function, Endurance
#GRFS128
GID: 4551; Last update: 06.11.2017
More information: Original Article

Research Studies (2017)

The Gambian Bone and Muscle Ageing Study: Baseline Data from a Prospective Observational African Sub-Saharan Study.

The Gambian Bone and Muscle Ageing Study is a prospective observational study investigating bone and muscle ageing in men and women from a poor, subsistence farming community of The Gambia, West Africa. Musculo weiter...

Author: Zengin A, Fulford AJ, Sawo Y, Jarjou LM, Schoenmakers I, Goldberg G, Prentice A, Ward KA
Source: Front Endocrinol (Lausanne), 2017; 8(): 219, PMID: 28912754
GID: 4531; Last update: 02.10.2017
More information: Original Article

Research Studies (2017)

Associations of Childhood and Adulthood Cognition with Bone Mineral Density in Later Adulthood: A Population-Based Longitudinal Study.

This study explores the association between cognitive ability in childhood and midlife and bone health outcomes in early old age; and the relationships of these bone measures with contemporaneous and subsequent weiter...

Author: Bendayan R, Kuh D, Cooper R, Muthuri S, Muniz-Terrera G, Adams J, Ward K, Richards M
Source: Front Aging Neurosci, 2017; 9(): 241, PMID: 28790912
GID: 4537; Last update: 02.10.2017
More information: Original Article

Research Studies (2017)

Evaluating the efficacy of functional electrical stimulation therapy assisted walking after chronic motor incomplete spinal cord injury: effects on bone biomarkers and bone strength.

OBJECTIVES: To determine the efficacy of functional electrical stimulation therapy assisted walking (FES-T) compared to a conventional aerobic and resistance training (CONV) with respect to bone biomarkers and weiter...

Author: Craven BC, Giangregorio LM, Alavinia SM, Blencowe LA, Desai N, Hitzig SL, Masani K, Popovic MR
Source: J Spinal Cord Med, 2017; 40(6): 1-11, PMID: 28929919
GID: 4525; Last update: 25.09.2017

Research Studies (2017)

Muscle Deficits in Rheumatoid Arthritis Contribute to Inferior Cortical Bone Structure and Trabecular Bone Mineral Density.

OBJECTIVE: Rheumatoid arthritis (RA) is associated with muscle loss, osteoporosis, and fracture. We examined associations between skeletal muscle mass, strength, and quality and trabecular and cortical bone def weiter...

Author: Baker JF, Long J, Mostoufi-Moab S, Denburg M, Jorgenson E, Sharma P, Zemel BS, Taratuta E, Ibrahim S, Leonard MB
Source: J Rheumatol, 2017; 44(12): 1777-1785, PMID: 28916544
GID: 4526; Last update: 25.09.2017

Research Studies (2013)

Mineral metabolism and cortical volumetric bone mineral density in childhood chronic kidney disease.

CONTEXT: The relationships among cortical volumetric bone mineral density (CortBMD) and comprehensive measures of mineral metabolism have not been addressed in chronic kidney disease (CKD). OBJECTIVE: The aim o weiter...

Author: Denburg MR, Tsampalieros AK, de Boer IH, Shults J, Kalkwarf HJ, Zemel BS, Foerster D, Stokes D, Leonard MB
Source: J Clin Endocrinol Metab, 2013; 98(5): 1930-8, PMID: 23547048
GID: 4521; Last update: 18.09.2017

Research Studies (2017)

Mechanical basis of bone strength: influence of bone material, bone structure and muscle action.

This review summarises current understanding of how bone is sculpted through adaptive processes, designed to meet the mechanical challenges it faces in everyday life and athletic pursuits, serving as an update weiter...

Author: Hart NH, Nimphius S, Rantalainen T, Ireland A, Siafarikas A, Newton RU
Source: J Musculoskelet Neuronal Interact, 2017; 17(3): 114-139, PMID: 28860414
Keywords: Bone Geometry, Mechanostat, Bone adaptation
GID: 4503; Last update: 06.09.2017

Research Studies (2017)

Experience with jumping mechanography in children with cerebral palsy.

OBJECTIVES: Jumping mechanography provides robust motor function indicators among healthy children. The aim of the study was to assess the reproducibility and validity of jumping mechanography conducted as sing weiter...

Author: Duran I, Martakis K, Stark C, Alberg E, Bossier C, Semler O, Schoenau E
Source: J Musculoskelet Neuronal Interact, 2017; 17(3): 237-245, PMID: 28860426
Keywords: leonardo, CP
GID: 4505; Last update: 06.09.2017

Research Studies (2017)

Feasibility and acceptability of using jumping mechanography to detect early components of sarcopenia in community-dwelling older women.

OBJECTIVE: To determine the feasibility and acceptability of using peak power and force, measured by jumping mechanography (JM), to detect early age-related features of sarcopenia in older women. METHODS: Commu weiter...

Author: Hannam K, Hartley A, Clark EM, Aihie Sayer A, Tobias JH, Gregson CL
Source: J Musculoskelet Neuronal Interact, 2017; 17(3): 246-257, PMID: 28860427
GID: 4506; Last update: 06.09.2017

Research Studies (2017)

Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures.

Low bone mineral density (BMD) and an increased fracture incidence are two extraintestinal complications associated with inflammatory bowel disease (IBD). We aimed to evaluate musculoskeletal traits and assess weiter...

Author: Maratova K, Hradsky O, Matyskova J, Copova I, Soucek O, Sumnik Z, Bronsky J
Source: Eur J Pediatr, 2017; 176(10): 1355-1363, PMID: 28840427
GID: 4500; Last update: 01.09.2017

Research Studies (2017)

Please Don"t Move-Evaluating Motion Artifact From Peripheral Quantitative Computed Tomography Scans Using Textural Features.

Most imaging methods, including peripheral quantitative computed tomography (pQCT), are susceptible to motion artifacts particularly in fidgety pediatric populations. Methods currently used to address motion ar weiter...

Author: Rantalainen T, Chivers P, Beck BR, Robertson S, Hart NH, Nimphius S, Weeks BK, McIntyre F, Hands B, Siafarikas A
Source: J Clin Densitom S1094-6950(17), 2017; S1094-6950(17): 30022-7, PMID: 28801168
GID: 4484; Last update: 31.08.2017

Research Studies (2017)

Musculoskeletal health in newly diagnosed children with Crohn"s disease.

We evaluated the impact of Crohn"s disease on muscle and bone strength, mass, density, and geometry in children with newly diagnosed CD and found profound muscle and bone deficits; nevertheless, the prevalence weiter...

Author: Ward LM, Ma J, Rauch F, Benchimol EI, Hay J, Leonard MB, Matzinger MA, Shenouda N, Lentle B, Cosgrove H, Scharke M, Konji VN, Mack DR
Source: Osteoporos Int, 2017; 28(): 3169–3177, PMID: 28791436
GID: 4480; Last update: 14.08.2017

Research Studies (2017)

Muscle abnormalities in osteogenesis imperfecta.

Osteogenesis imperfecta (OI) is mainly characterized by bone fragility but muscle abnormalities have been reported both in OI mouse models and in children with OI. Muscle mass is decreased in OI, even when shor weiter...

Author: Veilleux LN, Trejo P, Rauch F
Source: J Musculoskelet Neuronal Interact, 2017; 17(2): 1-7, PMID: 28574406
Keywords: pQCT Muscle
GID: 4474; Last update: 12.07.2017
More information: Original Article

Research Studies (2017)

Determinants of bone mineral density in young Australian women; results from the Safe-D study.

The study aimed to explore determinants of bone parameters in young women. Most bone parameters were associated with height and lean mass. Bone parameters were not associated with vitamin D status. Future resea weiter...

Author: Callegari ET, Garland SM, Gorelik A, Wark JD
Source: Osteoporos Int, 2017; 28(9): 2619-2631, PMID: 28660495
GID: 4467; Last update: 03.07.2017

Research Studies (2017)

Muscle power in children, youth and young adults who acquired HIV perinatally.

OBJECTIVES: To compare muscle power between youth who acquired HIV perinatally and HIV unexposed uninfected (HUU) youth. METHODS: We assessed muscle power (relative to body mass, Pmax/mass), muscle force normal weiter...

Author: Macdonald EtaMu, Nettlefold L, Maan EJ, Cote H, Alimenti A
Source: J Musculoskelet Neuronal Interact, 2017; 17(2): 27-37, PMID: 28574409
GID: 4455; Last update: 06.06.2017
More information: Original Article

Research Studies (2017)

Associations of muscle force, power, cross-sectional muscle area and bone geometry in older UK men.

BACKGROUND: Ageing is associated with sarcopenia, osteoporosis, and increased fall risk, all of which contribute to increased fracture risk. Mechanically, bone strength adapts in response to forces created by m weiter...

Author: Zengin A, Pye SR, Cook MJ, Adams JE, Rawer R, Wu FCW, O"Neill TW, Ward KA
Source: J Cachexia Sarcopenia Muscle, 2017; doi:10.1002/jcsm.12198: , PMID: 28474432
GID: 4425; Last update: 24.04.2017
More information: Original Article

Research Studies (2017)

Static postural control in youth with osteogenesis imperfecta type I

Objective: To assess static postural control in eyes-open and eyes-closed conditions in 4 individuals with osteogenesis imperfecta (OI) type I as compared to typically developing (TD) 5 individuals. The secon weiter...

Author: Pouliot-Laforte A, LemayM , Rauch F, Veilleux LN
Source: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2017;
Keywords: Posturography
GID: 4424; Last update: 24.04.2017

Research Studies (2015)

Measuring Muscle and Fat with Peripheral Quantitative Computed Tomography: Precision, Annual Changes, Monitoring Intervals, and Associations with Fall Status in Older Adults

Objectives: The overall aim of this thesis was to investigate the precision error, annual changes, and monitoring time intervals of muscle and fat outcomes measured by peripheral quantitative computed tomograp weiter...

Author: Andrew William Frank-Wilson
Source: Thesis, 2015;
GID: 4411; Last update: 11.04.2017

Research Studies (2017)

Cardiovascular calcification and subcortical bone demineralization in hypertension.

The present study investigated cardiovascular calcification, peripheral bone mineral density (BMD), and lab indices in hypertensive patients aged 55-74 years without severe kidney dysfunction. Cardiovascular c weiter...

Author: Cirillo C, Bilancio G, Natale F, Concilio C, Russo MG, Calabro P, Cirillo M
Source: Hypertens Res, 2017; 40(9): 825-830, PMID: 28381870
GID: 4408; Last update: 10.04.2017

Research Studies (2017)

Lower Jump Power Rather Than Muscle Mass Itself is Associated with Vertebral Fracture in Community-Dwelling Elderly Korean Women.

Sarcopenia is considered to be a risk factor for osteoporotic fracture, which is a major health problem in elderly women. In this study, we aimed to investigate the association of sarcopenia, with regard to mu weiter...

Author: Lee EY, Lee SJ, Kim KM, Seo DH, Lee SW, Choi HS, Kim HC, Youm Y, Kim CO, Rhee Y
Source: Calcif Tissue Int, 2017; 100(6): 585-594, PMID: 28275826
GID: 4405; Last update: 05.04.2017

Research Studies (2006)

Effekte eines niedrigfrequenten Ganzkörpervibrationstrainings auf dem Galileo 2000

Zusammenfassung: Dem Ganzkörpertraining wird der präventive und rehabilitative Nutzen nachgesagt, die Mineralisierung der Knochen zu fördern und darüber hinaus einer allgemeinen Muskeldegeneration entgegen weiter...

Author: Huber G, Weiss K, Eckert K
Source: B & G, 2006; 22(2): 52-57
GID: 4395; Last update: 01.04.2017

Research Studies (2017)

What"s the secret behind the benefits of whole-body vibration training in patients with COPD? A randomized, controlled trial.

BACKGROUND: Several studies have shown that whole-body vibration training (WBVT) improves exercise capacity in patients with severe COPD. The aim of this study was to investigate the determinants of improved e weiter...

Author: Gloeckl R, Jarosch I, Bengsch U, Claus M, Schneeberger T, Andrianopoulos V, Christle JW, Hitzl W, Kenn K
Source: Respir Med, 2017; 126: 17-24, PMID: 28427544
Keywords: COPD, Muslce Power, Balance, Mechanography
#GRFS144
GID: 4386; Last update: 20.03.2017

Research Studies (2018)

Peripheral Quantitative Computed Tomography (pQCT) Measures Contribute to the Understanding of Bone Fragility in Older Patients With Low-trauma Fracture.

Dual-energy X-ray absorptiometry (DXA) as currently used has limitations in identifying patients with osteoporosis and predicting occurrence of fracture. We aimed to express peripheral quantitative computed to weiter...

Author: Jiang H, Yates CJ, Gorelik A, Kale A, Song Q, Wark JD
Source: J Clin Densitom, 2018; 21(1): 140-147, PMID: 28285742
GID: 4385; Last update: 20.03.2017

Research Studies (2017)

A Design Method for FES Bone Health Therapy in SCI.

FES assisted activities such as standing, walking, cycling and rowing induce forces within the leg bones and have been proposed to reduce osteoporosis in spinal cord injury (SCI). However, details of the applie weiter...

Author: Andrews B, Shippen J, Armengol M, Gibbons R, Holderbaum W, Harwin W
Source: Eur J Transl Myol, 2017; 26(4): 6419, PMID: 28078075
GID: 4370; Last update: 24.02.2017

Research Studies (2017)

Whole-body vibration training as a workplace-based sports activity for employees with chronic low-back pain.

INTRODUCTION: The goal of this randomized and controlled study is to examine whether whole-body vibration (WBV) training is able to reduce back pain and physical disability in seated working office employees wi weiter...

Author: Kaeding TS, Karch A, Schwarz R, Flor T, Wittke TC, Kuck M, Boselt G, Tegtbur U, Stein L
Source: Scand J Med Sci Sports, 2017; 27(12): 2027-2039, PMID: 28185300
Keywords: Back-Pain, Workplace, Leonardo Balance
#GRFS98
GID: 4369; Last update: 17.02.2017

Research Studies (2017)

A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises.

BACKGROUND: Chemotherapy-induced polyneuropathy (CIPN) is a common toxicity after chemotherapy, immunomodulatory drugs or proteasome inhibitors, which is difficult to treat and may also have impact on quality o weiter...

Author: Schonsteiner SS, Bauder Missbach H, Benner A, Mack S, Hamel T, Orth M, Landwehrmeyer B, Sussmuth SD, Geitner C, Mayer-Steinacker R, Riester A, Prokein A, Erhardt E, Kunecki J, Eisenschink AM, Rawer R, Dohner H, Kirchner E, Schlenk RF
Source: Exp Hematol Oncol, 2017; 6: 5, PMID: 28194306
Keywords: Neuropathy
#GRFS36
GID: 4363; Last update: 08.02.2017
More information: Original Article

Research Studies (2017)

Muscle Mechanography: A Novel Method to Measure Muscle Function in Older Adults.

Muscle function decline is a commonly observed process that occurs with aging. Low muscle function, an essential component of sarcopenia, is associated with negative outcomes, including falls, fractures, and de weiter...

Author: Taani MH, Kovach CR, Buehring B
Source: Res Gerontol Nurs, 2017; 10(1): 17-24, PMID: 28112354
GID: 4357; Last update: 25.01.2017
More information: Original Article

Research Studies (2016)

Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest.

The impact of effective exercise against bone loss during experimental bed rest appears to be associated with increases in bone formation rather than reductions of bone resorption. Sclerostin and dickkopf-1 ar weiter...

Author: Belavy DL, Baecker N, Armbrecht G, Beller G, Buehlmeier J, Frings-Meuthen P, Rittweger J, Roth HJ, Heer M, Felsenberg D
Source: J Bone Miner Metab, 2016; 34(3): 354-65, PMID: 26056021
Keywords: Spaceflight, Immobilisation, Bone mineral density (BMD), Training, pQCT, space research
#GRFS68, #GRFS127
GID: 4356; Last update: 24.01.2017

Research Studies (2017)

Oscillatory whole-body vibration improves exercise capacity and physical performance in pulmonary arterial hypertension: a randomised clinical study.

OBJECTIVE: In patients with pulmonary arterial hypertension (PAH), supportive therapies may be beneficial in addition to targeted medical treatment. Here, we evaluated the effectiveness and safety of oscillator weiter...

Author: Gerhardt F, Dumitrescu D, Gartner C, Beccard R, Viethen T, Kramer T, Baldus S, Hellmich M, Schonau E, Rosenkranz S
Source: Heart, 2017; 103(8): 592-598, PMID: 28100544
Keywords: PAH, 6MWD, HRQoL
#GRFS80
GID: 4351; Last update: 20.01.2017
More information: Original Article

Research Studies (2017)

High-Intensity Jump Training Is Tolerated during 60 Days of Bed Rest and Is Very Effective in Preserving Leg Power and Lean Body Mass: An Overview of the Cologne RSL Study.

PURPOSE: Space agencies are looking for effective and efficient countermeasures for the degrading effects of weightlessness on the human body. The aim of this study was to assess the effects of a novel jump ex weiter...

Author: Kramer A, Kummel J, Mulder E, Gollhofer A, Frings-Meuthen P, Gruber M
Source: PLoS One, 2017; 12(1): e0169793, PMID: 28081223
Keywords: Bedrest Study Cololgne, RSL, Leonardo Jumping Table
GID: 4348; Last update: 13.01.2017
More information: Original Article

Research Studies (2016)

Lower insulin sensitivity is related to lower relative muscle cross-sectional area, lower muscle density and lower handgrip force in young and middle aged non-diabetic men.

OBJECTIVES: This study investigated whether an association between insulin resistance (IR) and muscle parameters is appreciable in young healthy men, independent of obesity. Furthermore, markers of muscle metab weiter...

Author: Gysel T, Tonoli C, Pardaens S, Cambier D, Kaufman JM, Zmierczak HG, Goemaere S, Lapauw B, Calders P
Source: J Musculoskelet Neuronal Interact, 2016; 16(4): 302-309, PMID: 27973382
Keywords: Insulin Resistance, Muscle Cross-sectional Area, Handgrip Strength, Estradiol
GID: 4347; Last update: 11.01.2017

Research Studies (2016)

Reference data for jumping mechanography in Canadian children, adolescents and young adults.

OBJECTIVES: To provide age- and sex-specific reference data for mechanography-derived parameters of muscle function in Canadian children and youth using the single two-legged jump (S2LJ) with hands-on-waist. ME weiter...

Author: Gabel L, Macdonald HM, Nettlefold L, Race D, McKay HA
Source: J Musculoskelet Neuronal Interact, 2016; 16(4): 283-295, PMID: 27973380
Keywords: SQ, CMJ
GID: 4311; Last update: 21.12.2016
More information: Original Article

Research Studies (2016)

Distal fibula fracture fixation: Biomechanical evaluation of three different fixation implants.

BACKGROUND: The goal of this study was to evaluate the biomechanical performance of three distal fibula fracture fixation implants in a matched pair cadaveric fibula model: (1) a 5-hole compression plate with weiter...

Author: Knutsen AR, Sangiorgio SN, Liu C, Zhou S, Warganich T, Fleming J, Harris TG, Ebramzadeh E
Source: Foot Ankle Surg, 2016; 22(4): 278-285, PMID: 27810029
GID: 4305; Last update: 29.11.2016

Research Studies (2016)

Bone turnover predicts change in volumetric bone density and bone geometry at the radius in men.

Peripheral quantitative computed tomography scans of the distal and midshaft radius were performed in 514 European men aged 40-79 years at baseline and a median of 4.3 years later. Age-related changes in volume weiter...

Author: Pye SR, Ward KA, Cook MJ, Laurent MR, Gielen E, Borghs H, Adams JE, Boonen S, Vanderschueren D, Wu FC, O"Neill TW
Source: Osteoporos Int, 2016; 28(3): 935-944, PMID: 27815569
GID: 4304; Last update: 29.11.2016
More information: Original Article

Research Studies (2017)

Cortical bone area predicts incident fractures independently of areal bone mineral density in older men.

CONTEXT: Areal bone mineral density (aBMD) measured using dual-energy X-ray absorptiometry (DXA) is used clinically to predict fracture but does not allow discrimination between the trabecular and cortical bone weiter...

Author: Ohlsson C, Sundh D, Wallerek A, Nilsson M, Karlsson M, Johansson H, Mellstrom D, Lorentzon M
Source: J Clin Endocrinol Metab, 2017; 102(2): 516-524, PMID: 27875059
GID: 4301; Last update: 29.11.2016

Research Studies (2016)

Vibration training improves disability status in multiple sclerosis: A pretest-posttest pilot study.

The purpose of this study was to examine the effects of an 8-week vibration training program on changing the disability level in people with multiple sclerosis (MS). Twenty-five adults with clinically-confirmed weiter...

Author: Yang F, Estrada EF, Sanchez MC
Source: J Neurol Sci, 2016; 369(): 96-101, PMID: 27653872
Keywords: Side-alternating vibration Mobility Patient Determined Disability Status Multiple Sclerosis Functional Composite
#GRFS82, #GRFS94
GID: 4248; Last update: 20.10.2016

Research Studies (2016)

Menopause, reproductive life, hormone replacement therapy and bone phenotype at age 60-64: a British birth cohort.

CONTEXT: Previous studies of menopausal age and length of reproductive life on bone are limited by retrospective reproductive histories, being cross sectional, or lacking gold standard bone technologies, or in weiter...

Author: Kuh D, Muthuri S, Cooper R, Moore A, MacKinnon K, Cooper C, Adams JE, Hardy R, Ward KA
Source: J Clin Endocrinol Metab 101(10):, 2016; 101(10): 3827-3837, PMID: 27472291
GID: 4224; Last update: 13.09.2016

Research Studies (2016)

Skeletal outcomes by peripheral quantitative computed tomography and dual-energy X-ray absorptiometry in adolescent girls with anorexia nervosa.

We conducted the first comparison of dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) outcomes in adolescent girls with anorexia nervosa. We observed deficits in bon weiter...

Author: DiVasta AD, Feldman HA, O"Donnell JM, Long J, Leonard MB, Gordon CM
Source: Osteoporos Int, 2016; 27(12): :549-3558, PMID: 27392467
Keywords: Anorexia nervosa . DXA . Malnutrition . Peripheral quantitative computed tomography
GID: 4230; Last update: 13.09.2016

Research Studies (2017)

Bone imaging in hypoparathyroidism.

Hypoparathyroidism (HypoPT) is an uncommon endocrine disorder characterized by chronic deficiency or absence of parathyroid hormone (PTH), which leads to a profound reduction in bone remodeling. Subjects with H weiter...

Author: Silva BC, Rubin MR, Cusano NE, Bilezikian JP
Source: Osteoporos Int, 2017; 28(2): 463-471, PMID: 27577725
GID: 4218; Last update: 13.09.2016

Research Studies (2016)

Muscle histology changes after short term vibration training in healthy controls

In search for additional counter measures of muscle atrophy vibration exercise training may have substantial effort for patients with neuromuscular disorders. To cover safety aspects and obtain muscle morpholog weiter...

Author: Schoser B
Source: Acta Myol, 2016; 34(2-3): 133-8, PMID: 27199541
Keywords: Muscle Histology, Muscle function, muscle power, muscle fiber
#GRFS29
GID: 4195; Last update: 27.06.2016
More information: Original Article

Research Studies (2015)

A Theoretical Study on the Evaluation of the Stability and Postural Sway, Based on the Results of the Confidence Ellipse

The aim of this theoretical study is to compare the results obtained by the confident ellipse with the postural sway identified during the balance test. The ability to control postural balance is an important f weiter...

Author: Bendo A, Kuvarati S, Skënderi D, Veveçka A
Source: IJSR, 2015; 4(1): 1776-9
GID: 4155; Last update: 20.05.2016
More information: Original Article

Research Studies (2016)

Effect of high-dose vitamin D supplementation on bone density in youth with osteogenesis imperfecta: A randomized controlled trial.

Osteogenesis imperfecta (OI) is a heritable condition characterized by fragile bones. Our previous studies indicated that serum 25-hydroxyvitamin D (25OHD) concentrations were positively associated with lumbar weiter...

Author: Plante L, Veilleux LN, Glorieux FH, Weiler H, Rauch F
Source: Bone, 2016; 86(): 36-42, PMID: 26924265
GID: 4153; Last update: 19.04.2016

Research Studies (2015)

Greater tibial bone strength in male tennis players than controls in the absence of greater muscle output

Background/Objective: The greatest forces experienced by bones result from muscular contractions muscles produce most force in high-velocity eccentric contractions. Bouncing movements, e.g., sprinting or hoppin weiter...

Author: Alex Ireland, Hans Degens, Bergita Ganse, Thomas Mark Maden-Wilkinson , Desiree Christin Wilks, Jörn Rittweger
Source: Journal of Orthopaedic Translation, 2015; 3(3): 142–151
GID: 4149; Last update: 19.04.2016
More information: Original Article

Research Studies (2016)

Human Musculoskeletal Models of Disuse

According to Frost’s mechanostat theory when the bone receives strains of about 800 to 1600 micro-strain retains its strength; increased strains promote formation (remodeling) up to a fracture point, and whe weiter...

Author: Dionyssiotis Y., Kapsokoulou A., Samlidi E., Iatridou G.
Source: JFSF, Journal of Frailty, Sarcopenia and Falls, 2016; 1(1): 4-7
GID: 4133; Last update: 11.04.2016
More information: Original Article

Research Studies (2016)

The negative effect of sitting time on bone is mediated by lean mass in pubertal children.

OBJECTIVE: Effects of time in moderate to vigorous physical activity (MVPA) and sitting (SIT) on bone were tested, hypothesizing that high MVPA would be positively associated with bone size and strength, offset weiter...

Author: Binkley TL, Specker BL
Source: J Musculoskelet Neuronal Interact, 2016; 16(1): 18-23, PMID: 26944819
GID: 4124; Last update: 09.03.2016
More information: Original Article

Research Studies (2016)

Effects of whole-body vibration training on physical function, bone and muscle mass in adolescents and young adults with cerebral palsy.

We performed a clinical trial on the effects of whole-body vibration training (WBVT) on muscle function and bone health of adolescents and young adults with cerebral palsy. Forty participants (11.3-20.8 years) weiter...

Author: Gusso S, Munns CF, Colle P, Derraik JG, Biggs JB, Cutfield WS, Hofman PL
Source: Sci Rep, 2016; 3;6: 22518, PMID: 26936535
Keywords: Galileo CP,Walking Distance, Chair Rising Test,improved muscle function
#GRFS13
GID: 4116; Last update: 09.03.2016
More information: Original Article

Research Studies (2005)

From mechanostat theory to development of the "Functional Muscle-Bone-Unit".

Bone densitometric data are often difficult to interpret in children and adolescents because of large inter- and intraindividual variations in bone size. Here, we propose a functional approach to bone densitom weiter...

Author: Schoenau E
Source: J Musculoskelet Neuronal Interact, 2005; 5(3): 232-8, PMID: 16172514
GID: 4107; Last update: 17.02.2016
More information: Original Article

Research Studies (2005)

The effect of exercise and nutrition on the mechanostat.

In this review, we discuss the effect of increased and decreased loading and nutrition deficiency on muscle and bone mass and strength (and bone length and architecture) independently and combined. Both exercis weiter...

Author: Bass SL, Eser P, Daly R
Source: J Musculoskelet Neuronal Interact, 2005; 5(3): 239-54, PMID: 16172515
GID: 4108; Last update: 17.02.2016
More information: Original Article

Research Studies (2016)

Acute effects of unilateral whole body vibration training on single leg vertical jump height and symmetry in healthy men.

[Purpose] The aim of the present study was to investigate the acute effects of unilateral whole body vibration training on height and symmetry of the single leg vertical jump in healthy men. [Subjects] Thirty m weiter...

Author: Shin S, Lee K, Song C
Source: J Phys Ther Sci, 2016; 27(12): 3923-8, PMID: 26834381
Keywords: Single leg vertical jump, Symmetry, Whole body vibration
#GRFS77
GID: 4076; Last update: 16.02.2016

Research Studies (2016)

Short-Term Effects of Whole-Body Vibration Combined with Task-Related Training on Upper Extremity Function, Spasticity, and Grip Strength in Subjects with Poststroke Hemiplegia: A Pilot Randomized Controlled Trial.

OBJECTIVE: The aim of this study was to determine the effect of whole-body vibration training combined with task-related training on arm function, spasticity, and grip strength in subjects with poststroke hemip weiter...

Author: Lee JS, Kim CY, Kim HD
Source: Am J Phys Med Rehabil, 2016; 95(8): 608-17, PMID: 26829094
Keywords: Hemiplegia,Motor Recovery,Task-Related Training, Upper Extremity,Whole-Body Vibration
#GRFS40
GID: 4077; Last update: 16.02.2016

Research Studies (2016)

The Relationship between Greater Pre-Pubertal Adiposity, Subsequent Age of Maturation and Bone Strength During Adolescence.

This longitudinal study investigated whether greater pre-pubertal adiposity was associated with subsequent timing of maturation and bone strength during adolescence in 135 girls and 123 boys participating in th weiter...

Author: Glass NA, Torner JC, Letuchy EM, Burns TL, Janz KF, Eichenberger Gilmore JM, Schlechte JA, Levy SM
Source: J Bone Miner Res, 2016; 31(7): 1455-65, PMID: 26861036
Keywords: Bone-fat interactions; Bone QCT; Osteoporosis; General population study; DXA
GID: 4089; Last update: 16.02.2016

Research Studies (2015)

Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters.

Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We weiter...

Author: Hoff P, Belavy DL, Huscher D, Lang A, Hahne M, Kuhlmey AK, Maschmeyer P, Armbrecht G, Fitzner R, Perschel FH, Gaber T, Burmester GR, Straub RH, Felsenberg D, Buttgereit F
Source: Cell Mol Immunol, 2015; 12(4): 483-92, PMID: 25382740
Keywords: Galileo Space, Immune System
#GRFS90
GID: 4070; Last update: 29.01.2016
More information: Original Article

Research Studies (2016)

Association of Jumping Mechanography-Derived Indices of Muscle Function with Tibial Cortical Bone Geometry.

Jumping mechanography has been developed to estimate maximum voluntary muscle forces. This study assessed associations of jumping mechanography-derived force and power measurements with tibial cortical bone geo weiter...

Author: Verroken C, Zmierczak HG, Goemaere S, Kaufman JM, Lapauw B
Source: Calcif Tissue Int, 2016; 98(): 446–455, PMID: 26671019
GID: 4043; Last update: 15.01.2016

Research Studies (2015)

Effect of age and sex on jumping mechanography and other measures of muscle mass and function.

OBJECTIVES: Sarcopenia increases falls and fracture risk. Sarcopenia clinical trials require robust quantitative tools to evaluate muscle function; jumping mechanography (JM) is likely one such tool. However, U weiter...

Author: Siglinsky E, Krueger D, Ward RE, Caserotti P, Strotmeyer ES, Harris TB, Binkley N, Buehring B
Source: J Musculoskelet Neuronal Interact, 2015; 15(4): 301-8, PMID: 26636275
GID: 4042; Last update: 10.12.2015
More information: Original Article

Research Studies (2013)

Erste klinische Erfahrungen mit der Leonardo Mechanograph® GW Ganganalyse bei Kindern mit neuro-muskulo-skeletalen Bewegungsstörungen

Author: Gilnaz Ranjbar Gigasari
Source: Inaugural-Dissertation zur Erlangung der Doktorwürde der Hohen Medizinischen Fakultät der Universität zu Köln, 2013;
GID: 4020; Last update: 27.10.2015

Research Studies (2015)

Posture Monitor for Vibration Exercise Training

Falls and fall-related fractures are common in the elderly and lead to negative health outcomes. Muscle function and balance impairment are important risk factors for falls. Traditional exercise improves muscl weiter...

Author: Hermus J, Hays C, Adamski M, Lider H, Westlund J, SCholp A, Webster J, Buehring B
Source: IEEE, 2015; 978-1-4799-1792-1:
Keywords: Galileo, Kinect
GID: 4019; Last update: 19.10.2015

Research Studies (2015)

Reliability of parameters during stair ascent measured with Leonardo Mechanograph((R)) Stair A in healthy subjects.

OBJECTIVES: Stair climbing (SC) as daily activity is assessed with different SC-tests, but none directly measures ground reaction force over several steps. The Leonardo Mechanograph Stair A has five steps and f weiter...

Author: Saxer S, Speich R, Toigo M, Mueller SM, Ulrich Somaini S
Source: J Musculoskelet Neuronal Interact, 2015; 15(3): 257-63, PMID: 26350944
Keywords: Leonardo SC, Leonardo Mechanography Stair
GID: 3968; Last update: 10.09.2015
More information: Original Article

Research Studies (2015)

Mechanography performance tests and their association with sarcopenia, falls and impairment in the activities of daily living - a pilot cross-sectional study in 293 older adults.

OBJECTIVES: Muscle mass and muscle power considerably decline with aging. The aim of the present study was to determine the association between muscular function using mechanography and sarcopenia, falls and im weiter...

Author: Dietzel R, Felsenberg D, Armbrecht G
Source: J Musculoskelet Neuronal Interact, 2015; 15(3): 249-56, PMID: 26350943
Keywords: Leonardo, Sarcopenia, Performance
GID: 3967; Last update: 10.09.2015
More information: Original Article

Research Studies (2013)

Bone density and neuromuscular function in older competitive athletes depend on running distance.

Individuals who are involved in explosive sport types, such as 100-m sprints and long jump, have greater bone density, leg muscle size, jumping height and grip strength than individuals involved in long-distan weiter...

Author: Gast U, Belavy DL, Armbrecht G, Kusy K, Lexy H, Rawer R, Rittweger J, Winwood K, Zielinski J, Felsenberg D
Source: Osteoporos Int, 2013; 24(7): 2033-42, PMID: 23242430
GID: 3954; Last update: 23.07.2015

Research Studies (2015)

Reduced bone strength and muscle force in women 27 years after anorexia nervosa.

CONTEXT: A substantial body of research findings indicate that muscle mass and bone mass are reduced in populations of anorexic females, even in such populations, whose anorexia nervosa had been in remission fo weiter...

Author: Mueller SM, Immoos M, Anliker E, Drobnjak S, Boutellier U, Toigo M
Source: J Clin Endocrinol Metab, 2015; (): jc20151011, PMID: 26086327
GID: 3929; Last update: 25.06.2015

Research Studies (2015)

Re-examining the surfaces of bone in boys and girls during adolescent growth: a 12-year mixed longitudinal pQCT study.

We revisit Stanley Garn"s theory related to sex differences in endocortical and periosteal apposition during adolescence using a 12-year mixed longitudinal study design. We used peripheral quantitative computed weiter...

Author: Gabel L, Nettlefold L, Brasher PM, Moore S, Ahamed Y, Macdonald HM, McKay HA
Source: J Bone Miner Res, 2015; 30(12): 2158-67, PMID: 26058373
Keywords: pQCT; BONE ACCRUAL; BONE STRENGTH; PEAK HEIGHT VELOCITY; GROWTH
GID: 3908; Last update: 17.06.2015

Research Studies (2015)

Physical activity in youth with osteogenesis imperfecta type I.

INTRODUCTION: Individuals with Osteogenesis Imperfecta (OI) type I often show muscular weakness. However, it is unclear whether muscular weakness is a consequence of physical inactivity or a result of the disea weiter...

Author: Pouliot-Laforte A, Veilleux LN, Rauch F, Lemay M
Source: J Musculoskelet Neuronal Interact, 2015; 15(2): 171-6, PMID: 26032209
GID: 3924; Last update: 17.06.2015
More information: Original Article

Research Studies (2015)

The functional muscle-bone unit in patients with osteogenesis imperfecta type I.

CONTEXT: Osteogenesis imperfecta (OI) type I is a heritable bone fragility disorder that is caused by mutations affecting collagen type I. We recently showed that patients with OI type I frequently have muscle weiter...

Author: Veilleux LN, Pouliot-Laforte A, Lemay M, Cheung MS, Glorieux FH, Rauch F
Source: Bone, 2015; 79(): 52-57, PMID: 26004918
GID: 3925; Last update: 17.06.2015

Research Studies (2008)

Cross-sectional fat area at the forearm in children and adolescents.

BACKGROUND: Cross-sectional fat area (FA) and muscle area have been recently used to describe local body composition at the forearm in children and adolescents. The present analysis intends to characterize FA weiter...

Author: Fricke O, Sumnik Z, Remer T, Stabrey A, Tutlewski B, Schoenau E
Source: Horm Res, 2008; 69(3): 160-4, PMID: 18219219
GID: 3864; Last update: 21.04.2015

Research Studies (2015)

Adolescence physical activity is associated with higher tibial pQCT bone values in adulthood after 28-years of follow-up - The Cardiovascular Risk in Young Finns Study.

High peak bone mass and strong bone phenotype are known to be partly explained by physical activity during growth but there are few prospective studies on this topic. In this 28-year follow-up of Cardiovascular weiter...

Author: Tolonen S, Sievanen H, Mikkila V, Telama R, Oikonen M, Laaksonen M, Viikari J, Kahonen M, Raitakari OT
Source: Bone, 2015; 75(): 77-83, PMID: 25697084
GID: 3853; Last update: 08.04.2015

Research Studies (2015)

Alterations in bone mineral density and lower extremity lean mass after hip arthroscopy in a professional female Ironman triathlete: a case study.

INTRODUCTION: Femoroacetabular impingement is a pathomechanical condition of the hip, which is often treated through arthroscopic techniques. The ensuing immobilization period is associated with decreases in m weiter...

Author: Mueller SM, Braendli S, Toigo M
Source: Springerplus, 2015; 4(): 70, PMID: 25713762
GID: 3851; Last update: 08.04.2015
More information: Original Article

Research Studies (2015)

Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults. A pQCT study.

To compare the independent influence of mechanical and non-mechanical factors on bone features, multiple regression analyses were performed between pQCT indicators of radius and tibia bone mass, mineralization weiter...

Author: Reina P, Cointry GR, Nocciolino L, Feldman S, Ferretti JL, Rittweger J, Capozza RF
Source: J Musculoskelet Neuronal Interact, 2015; 15(1): 10-22, PMID: 25730648
GID: 3850; Last update: 08.04.2015
More information: Original Article

Fundamental Studies (2015)

Longitudinal changes in lean mass predict pQCT measures of tibial geometry and mineralisation at 6-7years.

BACKGROUND: Studies in childhood suggest that both body composition and early postnatal growth are associated with bone mineral density (BMD). However, little is known of the relationships between longitudinal weiter...

Author: Moon RJ, Cole ZA, Crozier SR, Curtis EM, Davies JH, Gregson CL, Robinson SM, Dennison EM, Godfrey KM, Inskip HM, Cooper C, Harvey NC
Source: Bone, 2015; 75(): 105-10, PMID: 25703480
GID: 3852; Last update: 08.04.2015

Research Studies (2015)

Measurement of muscle and fat in postmenopausal women: precision of previously reported pQCT imaging methods.

Peripheral quantitative computed tomography (pQCT) imaging has been used to quantify muscle area and density as well as intermuscular adipose tissue (IMAT) and subcutaneous adipose tissue (SAT) area in the lowe weiter...

Author: Frank-Wilson AW, Johnston JD, Olszynski WP, Kontulainen SA
Source: Bone, 2015; 75(): 49-54, PMID: 25659205
GID: 3857; Last update: 08.04.2015

Research Studies (2015)

Lower-extremity muscle atrophy and fat infiltration after chronic spinal cord injury.

BACKGROUND: Atrophy and fatty-infiltration of lower-extremity muscle after spinal cord injury (SCI) predisposes individuals to metabolic disease and related mortality. OBJECTIVES: To determine the magnitude of weiter...

Author: Moore CD, Craven BC, Thabane L, Laing AC, Frank-Wilson AW, Kontulainen SA, Papaioannou A, Adachi JD, Giangregorio LM
Source: J Musculoskelet Neuronal Interact, 2015; 15(1): 32-41, PMID: 25730650
GID: 3859; Last update: 08.04.2015
More information: Original Article

Research Studies (2015)

Effects of five days of bed rest with intermittent centrifugation on neurovestibular function.

OBJECTIVES: We tested whether intermittent short-radius centrifugation was effective for mitigating alteration in balance and gait following bed rest. METHODS: Ten male subjects were exposed to 5 days of 6 degr weiter...

Author: Clement G, Bareille MP, Goel R, Linnarsson D, Mulder E, Paloski WH, Rittweger J, Wuyts FL, Zange J
Source: J Musculoskelet Neuronal Interact, 2015; 15(1): 60-8, PMID: 25730653
GID: 3860; Last update: 08.04.2015
More information: Original Article

Research Studies (2015)

The muscle-bone interaction in Turner syndrome.

OBJECTIVES: Turner syndrome (TS) is associated with an increased fracture rate due to reduced bone strength, which is mainly determined by skeletal muscle force. This study aimed to assess the muscle force-bone weiter...

Author: Soucek O, Matyskova J, Anliker E, Toigo M, Hlavka Z, Lebl J, Sumnik Z
Source: Bone, 2015; 74C(): 160-165, PMID: 25659206
GID: 3772; Last update: 16.02.2015

Research Studies (2015)

Reproducibility of jumping mechanography and traditional measures of physical and muscle function in older adults.

Improved approaches to assess functional change over time are needed to optimally reduce fall/fracture risk; jumping mechanography (JM) may be one such methodology. In this study, JM parameters were more reprod weiter...

Author: Buehring B, Krueger D, Fidler E, Gangnon R, Heiderscheit B, Binkley N
Source: Osteoporos Int, 2015; 26(2): 819-25, PMID: 25488806
GID: 3750; Last update: 10.02.2015

Research Studies (2014)

Physiological alterations after a marathon in the first 90-year-old male finisher: case study.

INTRODUCTION: Endurance performance decreases during ageing due to alterations in physiological characteristics, energy stores, and psychological factors. To investigate alterations in physiological characteris weiter...

Author: Mueller SM, Knechtle B, Knechtle P, Toigo M
Source: Springerplus, 2014; 3(): 608, PMID: 25392780
GID: 3662; Last update: 24.11.2014
More information: Original Article

Research Studies (2015)

Neuromuscular training based on whole body vibration in children with spina bifida: a retrospective analysis of a new physiotherapy treatment program.

INTRODUCTION: Spina bifida is the most common congenital cause of spinal cord lesions resulting in paralysis and secondary conditions like osteoporosis due to immobilization. Physiotherapy is performed for opt weiter...

Author: Stark C, Hoyer-Kuhn HK, Semler O, Hoebing L, Duran I, Cremer R, Schoenau E
Source: Childs Nerv Syst, 2015; 31(2): 301-9, PMID: 25370032
Keywords: Spina Bifida, Cologne Concept, Auf die Beine, Kölner Konzept, Kontrakturen, Contractures
#GRFS15, #GRFS148
GID: 3658; Last update: 24.11.2014

Research Studies (2014)

Feasibility, compliance, and efficacy of a randomized controlled trial using vibration in pre-pubertal children.

OBJECTIVE: Interventions utilizing vibration may increase bone mass and size which may reduce forearm fractures in children. This randomized controlled pilot trial tested the feasibility, compliance and effica weiter...

Author: Binkley TL, Parupsky EC, Kleinsasser BA, Weidauer LA, Specker BL
Source: J Musculoskelet Neuronal Interact, 2014; 14(3): 294-302, PMID: 25198224
Keywords: BMC, BMD, High-intensity Vibration, Low-intensity Vibration, DXA, pQCT
GID: 3632; Last update: 16.09.2014

Research Studies (2014)

Validity of an accelerometer as a vertical ground reaction force measuring device in healthy children and adolescents and in children and adolescents with osteogenesis imperfecta type I.

INTRODUCTION: Vertical ground reaction forces (vGRFs) are closely related to bone strength and development. It is therefore relevant to assess these forces in bone disorders accompanied with muscle weakness suc weiter...

Author: Pouliot-Laforte A, Veilleux LN, Rauch F, Lemay M
Source: J Musculoskelet Neuronal Interact, 2014; 14(2): 155-61, PMID: 24879019
GID: 3591; Last update: 29.08.2014

Research Studies (2014)

Jump power and force have distinct associations with cortical bone parameters: findings from a population enriched by individuals with high bone mass.

CONTEXT: Little is known of the relationships between muscle function and bone, based on the recently developed technique of jumping mechanography. OBJECTIVE: Our objective was to determine associations between weiter...

Author: Hardcastle SA, Gregson CL, Rittweger J, Crabtree N, Ward K, Tobias JH
Source: J Clin Endocrinol Metab, 2014; 99(1): 266-75, PMID: 24203064
GID: 3515; Last update: 20.03.2014

Research Studies (2014)

Whole body vibration training - improving balance control and muscle endurance.

Exercise combined with whole body vibration (WBV) is becoming increasingly popular, although additional effects of WBV in comparison to conventional exercises are still discussed controversially in literature. weiter...

Author: Ritzmann R, Kramer A, Bernhardt S, Gollhofer A
Source: PLoS One, 2014; 9(2): e89905, PMID: 24587114
GID: 3507; Last update: 20.03.2014

Research Studies (2014)

Study protocol, implementation, and verification of a short versatile upright exercise regime during 5 days of bed rest.

Objectives: This work provides a reference for future papers originating from this study by providing basic results on body mass, urine volume, and hemodynamic changes to 5 days of bed rest (BR) and by describi weiter...

Author: Mulder E, Frings-Meuthen P, von der Wiesche M, Clement G, Linnarsson D, Paloski WH, Wuyts FL, Zange J, Rittweger J
Source: J Musculoskelet Neuronal Interact, 2014; 14(1): 111-23, PMID: 24583546
Keywords: Smith Machine, bed rest, standardization, squat, heel raise
GID: 3496; Last update: 19.03.2014

Research Studies (2014)

Does progressive resistance and balance exercise reduce falls in residential aged care? Randomized controlled trial protocol for the SUNBEAM program

Introduction: Falls are common among older adults. It is reported that approximately 60% of residents of aged care facilities fall each year. This is a major cause of morbidity and mortality, and a significant weiter...

Author: Hewitt J, Refshauge KM, Goodall S, Henwood T, Clemson L
Source: Clinical Interventions in Aging, 2014; 9: 369-376
GID: 3480; Last update: 25.02.2014
More information: Original Article

Research Studies (2013)

Vitamin D status and bone health in immigrant versus Swedish women during pregnancy and the post-partum period.

Objective: We evaluated the association between vitamin D status and bone health in pregnant and post-partum immigrant versus Swedish women. Methods: We consecutively recruited 41 immigrant and 19 age-matched weiter...

Author: Dahlman I, Gerdhem P, Bergstrom I
Source: J Musculoskelet Neuronal Interact, 2013; 13(4): 464-9, PMID: 24292616
GID: 3420; Last update: 10.01.2014

Research Studies (2013)

Intra- and inter-rater reliability of jumping mechanography muscle function assessments.

Muscle function can be assessed through jumping mechanography, where portable ground reaction force plates collect dynamic information as a subject jumps. The aim of this study was to assess both intra- and in weiter...

Author: Matheson LA, Duffy S, Maroof A, Gibbons R, Duffy C, Roth J
Source: J Musculoskelet Neuronal Interact, 2013; 13(4): 480-6, PMID: 24292618
GID: 3419; Last update: 10.01.2014

Research Studies (2013)

Gymnastics participation is associated with skeletal benefits in the distal forearm: a 6-month study using peripheral Quantitative Computed Tomography.

Objectives: Musculoskeletal development of the upper limbs during exposure to weight-bearing loading is under-researched during early pubescent growth. The purpose was to assess the changes in upper body muscul weiter...

Author: Burt LA, Ducher G, Naughton GA, Courteix D, Greene DA
Source: J Musculoskelet Neuronal Interact, 2013; 13(4): 395-404, PMID: 24292609
GID: 3424; Last update: 10.01.2014

Research Studies (2013)

Variations in neuromuscular activity of thigh muscles during whole-body vibration in consideration of different biomechanical variables.

The intention of this study was to systematically analyze the impact of biomechanical variables in terms of different vibration frequencies, amplitudes and knee angles on quadriceps femoris and hamstring activi weiter...

Author: Perchthaler D, Horstmann T, Grau S
Source: J Sports Sci Med, 2013; 12(3): 439-46, PMID: 24149149
GID: 3370; Last update: 12.11.2013
More information: Original Article

Research Studies (2011)

Altersabhängige Muskelleistung und -kraft bei Senioren-Leistungssportlern verschiedener Sprungdisziplinen und die Anpassung des Knochens

Author: Böhme SA.
Source: Dissertation, 2011;
GID: 3347; Last update: 11.11.2013
More information: Original Article

Research Studies (2012)

Neuromuskuläres Assessment mit besonderer Betonung der spezifischen Sprungkraft im Kontext mit Knochendichtemessungen bei postmenopausalen Frauen

Author: Luhn F.
Source: Dissertation, 2012;
GID: 3348; Last update: 11.11.2013
More information: Original Article

Research Studies (2013)

A TRI-MODALITY COMPARISON OF VOLUMETRIC BONE MEASURE QUANTIFICATION USING 1.0 TESLA PERIPHERAL MAGNETIC RESONANCE IMAGING, PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY AND HIGHRESOLUTION- PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY IMAGES

This comparative study of peripheral (p) QCT, high-resolution pQCT (hr-pQCT) and 1.0 Tesla pMRI technologies focused on quantifying short-term test-retest reproducibility, validity, one-year detection limit a weiter...

Author: Wong A.K.O.
Source: Open Access Dissertations and Theses. Paper 8464, 2013;
Keywords: Morphometric parameters pQCT vs. HR-pQCT
GID: 3342; Last update: 06.11.2013
More information: Original Article

Scientific Publications (2010)

Osteoporosis in Men Chapter 52: Exercise programs for Pateints with osteoporosis

Author: Felsenberg D., Runge M.
Source: Osteoporosis in Men, 2010; 635-652
GID: 3308; Last update: 17.09.2013

Research Studies (2013)

Cross-sectional assessment of neuromuscular function using mechanography in women and men aged 20-85 years.

Objectives: The aim of this cross-sectional study was to examine the influence of age and sex on neuromuscular function of the lower limbs using mechanography. 704 adults aged 20-85 years from Germany participa weiter...

Author: Dietzel R, Gast U, Heine T, Felsenberg D, Armbrecht G
Source: J Musculoskelet Neuronal Interact, 2013; 13(3): 274-81, PMID: 23989252
GID: 3305; Last update: 10.09.2013
More information: Original Article

Research Studies (2013)

Reference data for jumping mechanography in healthy children and adolescents aged 6-18 years.

Objectives: To present gender-specific pediatric normative data on the main parameters of muscle function assessed using jumping mechanography. Methods: The study population included 796 non-selected Caucasian weiter...

Author: Sumnik Z, Matyskova J, Hlavka Z, Durdilova L, Soucek O, Zemkova D
Source: J Musculoskelet Neuronal Interact, 2013; 13(3): 259-73, PMID: 23989251
GID: 3304; Last update: 10.09.2013
More information: Original Article

Research Studies (2013)

The effect of physiotherapy in addition to testosterone replacement therapy on the efficiency of the motor system in men with hypogonadism.

BACKGROUND AND OBJECTIVE. The aim of this study was to analyze whether the addition of physiotherapy to testosterone replacement therapy provides added benefit in improving functional capacity of the motor syst weiter...

Author: Baceviciene R, Valonyte L, Ceponis J
Source: Medicina (Kaunas), 2013; 49(2): 71-7, PMID: 23888342
GID: 3285; Last update: 27.08.2013

Research Studies (2013)

Mechanography in childhood: references for grip force, multiple one-leg hopping force and whole body stiffness.

Objective: We sought to study and procure reference values for weight-related maximum isometric grip force (MIGF), maximum voluntary force in relation to body weight (Fmvrel) and peak whole body stiffness (pKwb weiter...

Author: Lang I, Busche P, Rakhimi N, Rawer R, Martin DD.
Source: J Musculoskelet Neuronal Interact., 2013; 13(2):: 227-35., PMID: 23728109
GID: 3221; Last update: 07.06.2013
More information: Original Article

Research Studies (2013)

pQCT-assessed relationships between diaphyseal design and cortical bone mass and density in the tibiae of healthy sedentary and trained men and women.

In a pQCT study of running-trained and untrained men and women we had shown that bone mass distribution along the tibia was adapted to the usage-derived stress pattern. To study the possible association between weiter...

Author: Capozza RF, Rittweger J, Reina PS, Mortarino P, Nocciolino LM, Feldman S, Ferretti JL, Cointry GR.
Source: J Musculoskelet Neuronal Interact., 2013; 13(2):: 195-205., PMID: 23728106
GID: 3219; Last update: 07.06.2013
More information: Original Article

Research Studies (2013)

Mechanography in childhood: references for force and power in counter movement jumps and chair rising tests.

Objective: We sought to procure age- and gender- related reference data and study the characteristics of body weight related peak force (pFrel), body mass related peak power (pPrel) for counter movement jumps ( weiter...

Author: Busche P, Rawer R, Rakhimi N, Lang I, Martin DD.
Source: J Musculoskelet Neuronal Interact., 2013; 13(2):: 213-26., PMID: 23728108
GID: 3220; Last update: 07.06.2013
More information: Original Article

Research Studies (2013)

Bone Size and Bone Strength Are Increased in Obese Male Adolescents.

Context:Controversy exists on the effect of obesity on bone development during puberty.Objective:Our objective was to determine differences in volumetric bone mineral density (vBMD) and bone geometry in male ob weiter...

Author: Vandewalle S, Taes Y, Van Helvoirt M, Debode P, Herregods N, Ernst C, Roef G, Van Caenegem E, Roggen I, Verhelle F, Kaufman JM, De Schepper J.
Source: J Clin Endocrinol Metab., 2013; 98(7): 3019-28, PMID: 23666962
GID: 3199; Last update: 06.06.2013

Research Studies (2013)

Vibration or Balance Training on Neuromuscular Performance in Osteopenic Women.

Maintaining neuromuscular function in older age is an important topic for aging societies, especially for older women with low bone density who may be at risk of falls and bone fracture. This randomized control weiter...

Author: Stolzenberg N, Belavý DL, Rawer R, Felsenberg D.
Source: Int J Sports Med., 2013; 34(11): 956-62, PMID: 23549694
Keywords: osteoporosis menopause whole body vibration ground reaction force
GID: 3192; Last update: 06.06.2013

Research Studies (2013)

Progressive Adaptation in Physical Activity and Neuromuscular Performance during 520d Confinement.

To understand whether prolonged confinement results in reductions in physical activity and adaptation in the musculoskeletal system, six subjects were measured during 520 d isolation in the Mars500 study. We te weiter...

Author: Belavy DL, Gast U, Daumer M, Fomina E, Rawer R, Schiessl H, Schneider S, Schubert H, Soaz C, Felsenberg D
Source: PLoS One, 2013; 8(3): e60090, PMID: 23555896
Keywords: Mars500 Mission
GID: 3170; Last update: 10.04.2013

Research Studies (2013)

Vitamin D status and muscle function in children with neurofibromatosis type 1 (NF1).

Objectives: The aim of this cross-sectional study was to assess the vitamin D status and muscle function in children with NF1 compared with their unaffected siblings. Methods: NF1 children between 5 and 18 year weiter...

Author: Hockett CW, Eelloo J, Huson SM, Roberts SA, Berry JL, Chaloner C, Rawer R, Mughal MZ.
Source: J Musculoskelet Neuronal Interact., 2013; 13(1): 111-119, PMID: 23445921
GID: 3152; Last update: 14.03.2013
More information: Original Article

Research Studies (2013)

Whole-body vibration versus proprioceptive training on postural control in post-menopausal osteopenic women.

BACKGROUND: To prevent falls in the elderly, especially those with low bone density, is it necessary to maintain muscle coordination and balance. The aim of this study was to examine the effect of classical ba weiter...

Author: Stolzenberg N, Belavy DL, Rawer R, Felsenberg D
Source: Gait Posture, 2013; 38(3): 416-20, PMID: 23375357
GID: 3134; Last update: 13.03.2013

Research Studies (2013)

Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial.

Background: Glucocorticoid immunosuppressant therapy in pediatric kidney transplant (Tx) recipients does not allow the improvement of growth after Tx. Objective: To determine the effect of early steroid withdra weiter...

Author: Mericq V, Salas P, Pinto V, Cano F, Reyes L, Brown K, Gonzalez M, Michea L, Delgado I, Delucchi A.
Source: Horm Res Paediatr., 2013; 79: 88–96
Keywords: Pediatric kidney transplant · Steroid withdrawal · Metabolic · Growth benefits
GID: 3141; Last update: 13.03.2013

Research Studies (2013)

Tongue strength is associated with jumping mechanography performance and handgrip strength but not with classic functional tests in older adults.

OBJECTIVES: To determine whether classic muscle function tests and jumping mechanography (JM) are related to tongue strength. DESIGN: Cross-sectional. SETTING: Community. PARTICIPANTS: Ninety-seven community-dw weiter...

Author: Buehring B, Hind J, Fidler E, Krueger D, Binkley N, Robbins J
Source: J Am Geriatr Soc, 2013; 61(3): 418-22, PMID: 23379330
GID: 3116; Last update: 19.02.2013

Research Studies (2013)

Analysing gait using a force-measuring walkway: intrasession repeatability in healthy children and adolescents.

The goal of this study was to determine the repeatability of gait parameters measured by a force plate gait analysis system (Leonardo Mechanograph((R)) GW) in healthy children. Nineteen healthy children and ado weiter...

Author: Veilleux LN, Ballaz L, Robert M, Lemay M, Rauch F
Source: Comput Methods Biomech Biomed Engin, 2013; (): , PMID: 23360226
GID: 3109; Last update: 02.02.2013

Research Studies (2012)

Agreement between vertical ground reaction force and ground reaction force vector in five common clinical tests.

Mechanography is an innovative method to evaluate lower-limb dynamic muscle function. This technique is generally performed on force platforms that measure only the vertical component of ground reaction force ( weiter...

Author: Veilleux LN, Rauch F, Lemay M, Ballaz L
Source: J Musculoskelet Neuronal Interact, 2012; 12(4): 219-23, PMID: 23196264
GID: 3073; Last update: 08.12.2012
More information: Original Article

Research Studies (2012)

Peripheral QCT sector analysis reveals early exercise-induced increases in tibial bone mineral density.

Objectives: The purpose of this controlled trial was to determine whether subtle changes in mineralization and geometry of the tibia were evident following short term exercise interventions. Methods: Fifty-se weiter...

Author: Evans RK, Negus CH, Centi AJ, Spiering BA, Kraemer WJ, Nindl BC
Source: J Musculoskelet Neuronal Interact, 2012; 12(3): 155-64, PMID: 22947547
GID: 3039; Last update: 09.09.2012
More information: Original Article

Research Studies (2012)

Effect of exercise on bone structural traits, physical performance and body composition in breast cancer patients - A 12-month RCT.

In this 12-month RCT, we examined whether aerobic impact exercise training (3x/week) could facilitate breast cancer survivors" recovery by enhancing their bone structural strength, physical performance and body weiter...

Author: Nikander R, Sievanen H, Ojala K, Kellokumpu-Lehtinen P, Palva T, Blomqvist C, Luoto R, Saarto T
Source: J Musculoskelet Neuronal Interact, 2012; 12(3): 127-35, PMID: 22947544
GID: 3036; Last update: 09.09.2012
More information: Original Article

Research Studies (2012)

Is a small muscle mass index really detrimental for insulin sensitivity in postmenopausal women of various body composition status?

Objectives: We sought to determine if a small muscle mass index (MMI) is actually detrimental for insulin sensitivity when studying a large group of postmenopausal women displaying various body composition stat weiter...

Author: Lebon J, Aubertin-Leheudre M, Bobeuf F, Lord C, Labonte M, Dionne IJ
Source: J Musculoskelet Neuronal Interact, 2012; 12(3): 116-26, PMID: 22947543
GID: 3035; Last update: 09.09.2012
More information: Original Article

Research Studies (2012)

Muscle Function, but Not Muscle Mass, is Related to Balance Confidence in Older Adults

Background: Both impaired muscle function and low muscle mass are included in recent consensus sarcopenia definitions. Sarcopenia is associated with increased risk of falls and fear of falling. Self-reported h weiter...

Author: Buehring B, Fidler E, Libber J, Krueger D, Binkley N
Source: ISCD, 2012;
GID: 3006; Last update: 22.06.2012

Research Studies (2012)

Jumping Mechanography and Classic Muscle Function Tests Effects of Age and Gender

Background: Sarcopenia is a risk factor for falls and fractures. As muscle function predicts disability and mortality better than muscle mass, recent consensus sarcopenia definitions include measures of both weiter...

Author: Fidler E, Buehring B, Libber J, Checovich M, Krueger D, Binkley N
Source: ISCD, 2012;
GID: 3005; Last update: 22.06.2012

Research Studies (2012)

Functional assessment of the muscle-bone unit in the lower leg.

Based on the mechanostat theory and the muscle-bone hypothesis, a methodological assessment of the musculoskeletal status in health and disease should relate maximum muscle force in relation to bone mass and g weiter...

Author: Anliker E, Toigo M
Source: J Musculoskelet Neuronal Interact, 2012; 12(2): 46-55, PMID: 22647277
GID: 2980; Last update: 05.06.2012
More information: Original Article

Research Studies (2012)

Effects of jumping exercise on maximum ground reaction force and bone in 8- to 12-year-old boys and girls: a 9-month randomized controlled trial.

Objectives: To assess adaptations of the lower leg muscle-bone unit in 8- to 12-year-old children following a randomized controlled jumping exercise intervention for 9 months. Methods: Twelve boys and 10 girls weiter...

Author: Anliker E, Dick C, Rawer R, Toigo M
Source: J Musculoskelet Neuronal Interact, 2012; 12(2): 56-67, PMID: 22647278
GID: 2981; Last update: 05.06.2012
More information: Original Article

Research Studies (2012)

Abnormalities in Muscle Density and Muscle Function in Hypophosphatemic Rickets.

Context:Animal studies suggest that hypophosphatemic rickets (HPR) is associated with muscle function deficits, but it is unknown whether humans with HPR have a muscle disorder.Objective:Our objective was to a weiter...

Author: Veilleux LN, Cheung M, Ben Amor M, Rauch F
Source: J Clin Endocrinol Metab, 2012; 97(8): E1492-8, PMID: 22639288
GID: 2979; Last update: 05.06.2012

Research Studies (2012)

Effect of different collegiate sports on cortical bone in the tibia.

Objectives: The purpose of this study was to determine the effect of sports participation on cortical bone in the tibia. Methods: 53 female collegiate athletes (25 cross-country, 16 soccer, and 12 volleyball) a weiter...

Author: Weidauer LA, Eilers MM, Binkley TL, Vukovich MD, Specker BL
Source: J Musculoskelet Neuronal Interact, 2012; 12(2): 68-73, PMID: 22647279
GID: 2982; Last update: 05.06.2012
More information: Original Article

Research Studies (2012)

Muscle force and power in obese and overweight children.

The study investigated differences in skeletal muscle function between obese and non-obese children using a force platform. Forty obese children and adolescents (age range 8 to 18 years; 21 girls) and 40 age- weiter...

Author: Rauch R, Veilleux LN, Rauch F, Bock D, Welisch E, Filler G, Robinson T, Burrill E, Norozi K
Source: J Musculoskelet Neuronal Interact, 2012; 12(2): 80-3, PMID: 22647281
GID: 2983; Last update: 05.06.2012
More information: Original Article

Research Studies (2012)

Short-Duration Resistive Exercise Sustains Neuromuscular Function after Bed Rest.

PURPOSE: To assess the effectiveness of a short duration, three times weekly, high-load resistive exercise program on preventing deterioration in neuromuscular function after prolonged bed rest. METHODS: Twenty weiter...

Author: Gast U, John S, Runge M, Rawer R, Felsenberg D, Belavy DL
Source: Med Sci Sports Exerc., 2012; (44): 1764-72, PMID: 22460472
Keywords: BBR2, BedRest, Kuskelfunktion
#GRFS69
GID: 2942; Last update: 10.04.2012

Research Studies (2012)

Effect of level of farm mechanization early in life on bone later in life.

Objective: To determine whether an active rural lifestyle during childhood and adolescence, defined as low farm mechanization, was associated with bone measures later in life. Methods: DXA bone data from total weiter...

Author: McCormack LA, Binkley TL, Specker BL
Source: J Musculoskelet Neuronal Interact, 2012; 12(1): 7-15, PMID: 22373946
GID: 2905; Last update: 07.03.2012
More information: Original Article

Research Studies (2012)

Muscle-bone characteristics in children with Prader-Willi syndrome.

BACKGROUND: A decrease in muscle mass, low motor performance, and normal lumbar spine bone mineral density (BMD) have been reported in children with Prader-Willi syndrome (PWS). However, these data are limited weiter...

Author: Edouard T, Deal C, Van Vliet G, Gaulin N, Moreau A, Rauch F, Alos N
Source: J Clin Endocrinol Metab, 2012; 97(2): E275-81, PMID: 22162467
GID: 2874; Last update: 06.02.2012

Research Studies (2012)

Is 8 weeks of side-alternating whole-body vibration a safe and acceptable modality to improve functional performance in multiple sclerosis?

Purpose: To examine whether an 8-week period of side-alternating whole-body vibration (WBV) exercise is an acceptable and effective exercise intervention to improve and maintain functional performance in multi weiter...

Author: Mason RR, Cochrane DJ, Denny GJ, Firth EC, Stannard SR
Source: Disabil Rehabil, 2012; 34(8): 647-54, PMID: 21992525
Keywords: MS
GID: 2852; Last update: 06.02.2012

Research Studies (2012)

Acute Effects of Whole-Body Vibration on Jump Force and Jump Rate of Force Development: A Comparative Study of Different Devices.

Bagheri, J, van den Berg-Emons, RJ, Pel, JJ, Horemans, HL, and Stam, HJ. Acute effects of whole-body vibration on jump force and jump rate of force development: A comparative study of different devices. J Stren weiter...

Author: Bagheri J, van den Berg-Emons RJ, Pel JJ, Horemans HL, Stam HJ
Source: J Strength Cond Res., 2012; 26(3): 691-6, PMID: 22126972
GID: 2835; Last update: 06.02.2012

Scientific Publications (2011)

Gesundheit im Unternehmen managen und fördern: Vibrationstraining als effektive Maßnahme für Mitarbeiter

Das vorliegende Buch bietet einen umfassenden Überblick zum Thema Gesundheit, Gesundheitsmanagement und Gesundheitsförderung in Unternehmen. Aufgrund der steigenden Altersstruktur der Erwerbspersonen nehmen a weiter...

Author: Seitz D.
Source: ISBN 3639384326, 2011;
Keywords: Betriebliche Gesundheitsförderung
GID: 2779; Last update: 08.12.2011

Research Studies (2011)

Side-to-side differences in bone strength in master jumpers and sprinters.

Introduction: This study evaluated side-to-side difference in tibial bone structure, calf muscle cross-sectional area (CSA) and hopping force in master athletes as a result of training for sports with different weiter...

Author: Ireland A, Korhonen M, Heinonen A, Suominen H, Baur C, Stevens S, Degens H, Rittweger J
Source: J Musculoskelet Neuronal Interact, 2011; 11(4): 298-305, PMID: 22130138
GID: 2777; Last update: 06.12.2011
More information: Original Article

Research Studies (2011)

Contralateral comparison of bone geometry, BMD and muscle function in the lower leg and forearm after stroke.

Objective: The aim of the study was to investigate the side-to-side differences of the upper and lower limbs in chronic stroke patients by means of peripheral quantitative computed tomography (pQCT). Methods: T weiter...

Author: Talla R, Galea M, Lythgo N, Angeli T, Eser P
Source: J Musculoskelet Neuronal Interact, 2011; 11(4): 306-13, PMID: 22130139
GID: 2778; Last update: 06.12.2011
More information: Original Article

Research Studies (2011)

The Muscle Activity In The Lower Limb During Single Legged Hop In Children With Juvienile Idiophathic Arthritis

The one-legged hop was used to assess the muscle function of children diagnosed with Juvenile Idiopathic Arthritis. Vertical hopping relies heavily on the triceps surae musculature, and the calcaneal tendon mak weiter...

Author: Dwyer KD; Kennedy MJ; Lamontagne M; Roth J
Source: ISB, Brussels, 2011; 1162
GID: 2753; Last update: 05.10.2011

Research Studies (2011)

Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise.

Protein calcium sensors of the Homer family have been proposed to modulate the activity of various ion channels and nuclear factor of activated T cells (NFAT), the transcription factor modulating skeletal musc weiter...

Author: Salanova M, Bortoloso E, Schiffl G, Gutsmann M, Belavy DL, Felsenberg D, Furlan S, Volpe P, Blottner D
Source: FASEB J, 2011; (): , PMID: 21885651
Keywords: BBR2
GID: 2748; Last update: 28.09.2011

Research Studies (2011)

Muscle Density, a surrogate of intermuscular adiposity, derived from pQCT is an independent correlate of fractures in women

BACKGROUND: bone, muscle and fat have a common progenitor, the mesenchymal stem cell preferred differentiation into adipocytes can lead to loss of bone architecture fat infiltration in bone marrow and muscle i weiter...

Author: Wong AKO, Bhargava A, Beattie KA, Gordon CL, Pickard L, Webber CE, Papaioannou A, Adachi JD
Source: ASBMR, San Diego, 2011;
Keywords: Muscle Density
GID: 2743; Last update: 21.09.2011

Research Studies (2011)

Correlation of Different Muscle Function Tests in Older Adults

Background: Evidence is growing that sarcopenia is an independent risk factor for falls and osteoporotic fractures. Definition of sarcopenia based on mass alone is not ideal as muscle function appears to bett weiter...

Author: Buehring B, Fidler E, Krueger D, Binkley N
Source: ASBMR, Anual Meeting 2011, San Diego, 2011;
GID: 2727; Last update: 09.09.2011

Research Studies (2011)

Combined Effects of Whole-Body Vibration, Resistance Exercise, and Vascular Occlusion on Skeletal Muscle and Performance.

The purpose of this study was to evaluate the effects of a new high-intensity training modality comprised of vibration exercise with superimposed resistance exercise and vascular occlusion (vibroX) on skeletal weiter...

Author: Item F, Denkinger J, Fontana P, Weber M, Boutellier U, Toigo M
Source: Int J Sports Med, 2011; 32(10): 781-7, PMID: 21870317
Keywords: enduracne, workout, suqat, Kniebeuge, Ausdauer
#GRFS12
GID: 2690; Last update: 29.08.2011

Research Studies (2011)

Changes in lower extremity muscle function after 56 days of bed rest.

Preservation of muscle function, known to decline in microgravity and simulation (bed rest), is important for successful spaceflight missions. Hence, there is great interest in developing interventions to prev weiter...

Author: Buehring B, Belavy DL, Michaelis I, Gast U, Felsenberg D, Rittweger J
Source: J Appl Physiol, 2011; 111(1): 87-94, PMID: 21527664
Keywords: BBR1, Muscle Function
#GRFS93
GID: 2665; Last update: 30.06.2011

Research Studies (2011)

Maximum Ground Reaction Force in Relation to Tibial Bone Mass in Children and Adults.

PURPOSE:: To assess maximum voluntary forefoot ground reaction force (Fm1LH) during multiple one-legged hopping (m1LH, a new jumping maneuver) and to determine the correlation between tibial volumetric bone min weiter...

Author: Anliker E, Rawer R, Boutellier U, Toigo M
Source: Med Sci Sports Exerc, 2011; (43): 2102-9, PMID: 21502901
GID: 2632; Last update: 19.04.2011

Research Studies (2012)

The effects of bed rest and counter measure exercise on the endocrine system in male adults - evidence for immobilization induced reduction in SHBG levels.

Background and Aim. There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and a weiter...

Author: Belavy DL, Seibel MJ, Roth HJ, Armbrecht G, Rittweger J, Felsenberg D
Source: J Endocrinol Invest, 2012; 35(1): 54-62, PMID: 21422800
Keywords: BBR
GID: 2606; Last update: 07.04.2011

Research Studies (2010)

Assessment of musculoskeletal system in women with jumping mechanography

The purpose of this study was to investigate and add reference data about the musculoskeletal system in women. The mechanography system of the Leonardo weiter...

Author: Dionyssiotis Y, Galanos A, Michas G, Trovas G, Lyritis GP
Source: Int J Womens Health., 2010; 1: 113-8, PMID: 21072281
GID: 2622; Last update: 07.04.2011

Research Studies (2011)

Additive impact of alfacalcidol on bone mineral density and bone strength in alendronate treated postmenopausal women with reduced bone mass

Objectives: Assessment of additive impact of alfacalcidol 1 weiter...

Author: Felsenberg D, Bock O, Börst H, Armbrecht G, Beller G, Degner C, Stephan-Oelkers M, Schacht E, Mazor Z, Hashimoto J, Roth HJ, Martus P, Runge M
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 34-45, PMID: 21364273
GID: 2587; Last update: 05.03.2011
More information: Original Article

Research Studies (2011)

Gait analysis using a force-measuring gangway: Intrasession repeatability in healthy adults

Objectives: The goal of the present study was to determine the repeatability of gait parameters measured by a force plate gait analysis system (Leonardo Mechanograph® GW). Methods: Fifteen healthy adult partic weiter...

Author: Veilleux LN, Robert M, Ballaz L, Lemay M, Rauch F
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 27-33, PMID: 21364272
Keywords: Gangway
GID: 2586; Last update: 05.03.2011
More information: Original Article

Research Studies (2011)

Inter-limb musculoskeletal differences in competitive ten-pin bowlers: A preliminary analysis

Objectives: To compare musculoskeletal characteristics of the loaded and non-loaded forearm and upper leg of competitive ten-pin bowlers. Methods: 10 competitive bowlers (30.6 weiter...

Author: Young KC, Sherk VD, Bemben DA
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 21-6, PMID: 21364271
GID: 2585; Last update: 05.03.2011
More information: Original Article

Research Studies (2010)

Do bone mineral density, bone geometry and the functional muscle-bone unit explain bone fractures in healthy children and adolescents

BACKGROUND/AIMS: Because the increasing fracture incidence has not been understood, the present study compares variables of the muscle-bone interaction to examine the hypothesis that an impaired adaptation of weiter...

Author: Beccard R, Land C, Semler O, Fricke O, Remer T, Stabrey A, Schoenau E
Source: Horm Res Paediatr., 2010; 74(5): 312-8, PMID: 20395668
GID: 2572; Last update: 22.02.2011

Fundamental Studies (2010)

Analyses of muscular mass and function: the impact on bone mineral density and peak muscle mass

Bone density and bone mass are commonly regarded as the essential parameters to describe fracture risk in osteology. Because fractures primarily depend on bone strength and secondarily on bone mass and density, weiter...

Author: Fricke O, Beccard R, Semler O, Schoenau E
Source: Pediatr Nephrol., 2010; 25(12): 2393-400, PMID: 20458595
GID: 2571; Last update: 22.02.2011

Research Studies (2010)

Relationship of muscle function to auxology in preterm born children at the age of seven years

BACKGROUND/AIMS: To characterize the relationship between muscle function and auxology in preterm born children. METHODS: Forty-five preterm born children (birth weight < or =1,500 g with mean +/- SD: 1,06 weiter...

Author: Fricke O, Roedder D, Kribs A, Tutlewski B, von Kleist-Retzow JC, Herkenrath P, Roth B, Schoenau E
Source: Horm Res Paediatr., 2010; 73(5): 390-7, PMID: 20389111
GID: 2573; Last update: 22.02.2011

Research Studies (2010)

Reproducibility of jumping mechanography in healthy children and adults

Objectives: To describe mechanographic tests that can be performed by patients with a range of functional abilities and to assess the reproducibility of test results in healthy adults and children. Methods: Fif weiter...

Author: Veilleux LN, Rauch F
Source: J Musculoskelet Neuronal Interact., 2010; 10(4): 256-66, PMID: 21116062
GID: 2483; Last update: 02.12.2010
More information: Original Article

Research Studies (2008)

Neuromuscular performance and bone structural characteristics in young healthy men and women

Muscle mass and strength have been shown to be important factors in bone strength. Low muscular force predisposes to falling especially among elderly. Regular exercise helps to prevent falls and resulting bone weiter...

Author: Rantalainen T, Heinonen A, Komi PV, Linnamo V
Source: Eur J Appl Physiol., 2008; 102(2): 215-22, PMID: 17926061
GID: 2450; Last update: 28.10.2010

Research Studies (1998)

The relationship between isokinetic quadriceps strength test and hop tests for distance and one-legged vertical jump test following anterior cruciate ligament reconstruction

Isokinetic measurements and functional tests are often used to assess function following knee ligament reconstruction using the opposite limb as a control. However, the question of whether the uninvolved leg ma weiter...

Author: Petschnig R, Baron R, Albrecht M
Source: J Orthop Sports Phys Ther., 1998; 28(1): 23-31, PMID: 9653687
GID: 2436; Last update: 19.10.2010

Research Studies (2010)

A Randomized, Controlled Trial of Vitamin D Supplementation upon Musculoskeletal Health in Postmenarchal Females

Context:There has been a resurgence of vitamin D deficiency rickets throughout the developed world, with infants and adolescents being primarily affected. Adolescence is a crucial period for muscle and bone min weiter...

Author: Ward KA, Das G, Roberts SA, Berry JL, Adams JE, Rawer R, Mughal MZ
Source: J Clin Endocrinol Metab., 2010; 95: 4643-4651, PMID: 20631020
GID: 2391; Last update: 01.09.2010

Research Studies (2010)

Calf muscle x-ray absorption is reduced in patients with chronic spinal cord injury, but not during 90 days of experimental bed rest

BACKGROUND: Immobilisation leads to muscular atrophy. However, certain types of immobilisation, such as e.g. denervation can also cause a fatty degeneration of skeletal muscle. As fat has lower x-ray absorpti weiter...

Author: Rittweger J
Source: Life in Space for Life on Earth, ESA, Triest, 2010;
Keywords: Muskeldichte, MXA
GID: 2300; Last update: 18.06.2010
More information: Original Article

Research Studies (2010)

Effect of a new physiotherapy concept on bone mineral density, muscle force and gross motor function in children with bilateral cerebral palsy

Objective: The purpose of this study was to determine the effect of a new physiotherapy concept on bone density, muscle force and motor function in bilateral spastic cerebral palsy children. Methods: In a retro weiter...

Author: Stark C, Nikopoulou-Smyrni P, Stabrey A, Semler O, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2010; 10(2): 151-8, PMID: 20516632
Keywords: mGMFM, Muscle Mass, DXA bone mineral density (BMD), Bone mineral COntent (BMC)
#GRFS72
GID: 2292; Last update: 07.06.2010
More information: Original Article

Research Studies (2010)

Muscle cross sectional area and grip torque contraction types are similarly related to pQCT derived bone strength indices in the radii of older healthy adults

Objectives: We sought to identify the variance in radius bone strength indices explained by forearm muscle cross sectional area (MCSA) and isometric (ISO), concentric (CON), or eccentric (ECC) grip torque in he weiter...

Author: Frank AW, Lorbergs AL, Chilibeck PD, Farthing JP, Kontulainen SA
Source: J Musculoskelet Neuronal Interact., 2010; 10(2): 136-41, PMID: 20516630
GID: 2290; Last update: 07.06.2010
More information: Original Article

Research Studies (2010)

Prevention of bone loss during 56 days of strict bed rest by side-alternating resistive vibration exercise

Bed rest is a recognized model for muscle atrophy and bone loss in space flight and in clinical medicine. We hypothesized that whole body vibration in combination with resistive exercise (RVE) would be an effec weiter...

Author: Rittweger J, Beller G, Armbrecht G, Mulder E, Buehring B, Gast U, Dimeo F, Schubert H, de Haan A, Stegeman DF, Schiessl H, Felsenberg D
Source: Bone, 2010; 46(1): 137-47, PMID: 19732856
Keywords: BBR, Space Research
#GRFS45
GID: 2285; Last update: 24.05.2010

Research Studies (2009)

Changes in joint angle, muscle-tendon complex length, muscle contractile tissue displacement, and modulation of EMG activity during acute whole-body vibration

It has been suggested that vibration causes small changes in muscle length, but to the best of our knowledge, these have yet to be demonstrated during whole-body vibration (WBV). This was an observational study weiter...

Author: Cochrane DJ, Loram ID, Stannard SR, Rittweger J
Source: Muscle Nerve., 2009; 40(3): 420-9, PMID: 19618430
GID: 2287; Last update: 24.05.2010

Research Studies (2010)

Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism

During and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whil weiter...

Author: Armbrecht G, Belavý DL, Gast U, Bongrazio M, Touby F, Beller G, Roth HJ, Perschel FH, Rittweger J, Felsenberg D
Source: Osteoporos Int., 2010; 21(4): 597-607, PMID: 19536451
Keywords: BBR
GID: 2288; Last update: 24.05.2010

Research Studies (2007)

Reference graphs of age-related changes in bone mass, volumetric density, design and strength of muscle-bone interactions in normal men and women.

Author: Feldman S, Capozza RF, Cointry GR, Ferretti SE, Reina PS, Homse B, Zapata M, Mansur JL, Ferretti JL
Source: ASBMR, 2007;
GID: 2224; Last update: 09.04.2010
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Research Studies (2007)

Relationships between diaphyseal geometry and cortical mineral density as assessed by pQCT in the human tibia. A pQCT study.

Author: Capozza R, Reina P, Cointry G, Feldman S, Castellini S, Rittweger J, Ferretti JL
Source: ASBMR, 2007;
GID: 2226; Last update: 09.04.2010
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Research Studies (2009)

Non-invasive (pQCT) biomechanical analysis of the whole human tibia in normal men and women

Author: Feldman S, Capozza R, Mortario P, Yelin I, Reina P, Schiessl H, Rittweger J, Ferretti JL, Cointry GR
Source: ASBMR, 2009;
GID: 2228; Last update: 09.04.2010
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Research Studies (2009)

Structural and biomechanical analysis of the whole tibia by pQCT in trained long-distance runners

Author: Feldman S, Capozza R, Mortarino P. Yelin I, Reina P, Ullna MR, Rittweger J, Ferretti JL, Cointry GR
Source: ASBMR, 2009;
GID: 2229; Last update: 09.04.2010
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Research Studies (2007)

Trabecular bone mass evaluation as related to cortical mass in the human leg. A pQCT study.

Author: Cointry GR, Capozza RF, Feldman S, Mortarino P, Maffei L, Alvarisqueta A, Ferretti JL
Source: ASBMR, 2007;
GID: 2227; Last update: 09.04.2010
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Research Studies (2010)

Age-Related Changes in Physical Function in Community-Dwelling People Aged 50-79 Years

[Purpose] We aimed to obtain the mean values for physical function tests in healthy community-dwelling people aged 50-79 years and to compare these values between age decades. [Subjects and Methods] We recr weiter...

Author: Tsubaki A, Kubo M, Kobayashi R, Jigami H, Takahashi HE
Source: J. Phys. Ther. Sci, 2010; 22/1: 23-27
GID: 2231; Last update: 09.04.2010
More information: Original Article

Research Studies (2009)

Mechanographic analyses in pediatrics: allometric scaling of "peak jump force" and its relationship to "maximal isometric grip force" in childhood and adolescence

BACKGROUND: Kinetic analyses of the neuromuscular system have become an important part in the diagnostics of metabolic bone disorders in pediatrics because of the relevance of the "Functional Muscle-Bone Unit". weiter...

Author: Fricke O, Stabrey A, Tutlewski B, Schoenau E
Source: Klin Padiatr., 2009; 221(7): 436-9, PMID: 20013567
GID: 2156; Last update: 13.01.2010

Research Studies (2006)

Building a Better Understanding of Basic Mechanical Principles Through Analysis of the Vertical Jump

An understanding of the basic mechanical principles governing movement is essential for the development of training programs, performance improvement, and injury prevention. The goal of this article is to revie weiter...

Author: Reiser RF, Rocheford EC, Armstrong CJ
Source: Strength and conditioning journal, 2006; 28(4): 70-80
GID: 2135; Last update: 05.01.2010

Research Studies (2009)

EFFECT OF SPORT ACTIVITY ON COUNTER MOVEMENT JUMP PARAMETERS IN JUVENILE STUDENTS

INTRODUCTION: The counter movement jump (CMJ) is a commonly used method in performance diagnostics to measure leg power (Frick et al., 1991). The use of arm movements during jumping can increase the release ve weiter...

Author: Richter A, Lang D, Strutzenberger G, Schwameder H
Source: ISBS, Conference Proceedings Archive, 27 International Conference on Biomechanics in Sports (2009), 2009;
GID: 2124; Last update: 28.12.2009
More information: Original Article

Research Studies (2009)

Skeletal geometry and indices of bone strength in artistic gymnasts

This review addresses bone geometry and indices of skeletal strength associated with exposure to gymnastic loading during growth. A brief background characterizes artistic gymnastics as a mechanical loading mod weiter...

Author: Dowthwaite JN, Scerpella TA
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 198-214, PMID: 19949278
GID: 2109; Last update: 18.12.2009
More information: Original Article

Research Studies (2009)

Resistive vibration exercise reduces lower limb muscle atrophy during 56-day bed-rest

Objectives: The current study aimed to examine the effectiveness of a resistive vibration exercise countermeasure during prolonged bed-rest in preventing lower-limb muscle atrophy. Methods: 20 male subjects und weiter...

Author: Belavý DL, Miokovic T, Armbrecht G, Rittweger J, Felsenberg D
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 225-35, PMID: 19949280
Keywords: BBR, Galileo Space
GID: 2083; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Age-dependency in bone mass and geometry: a pQCT study on male and female master sprinters, middle and long distance runners, race-walkers and sedentary people

Objective: To investigate whether athletic participation allows master athletes to preserve their good bone health into old age. Methods: Bone strength indicators of the tibia and the radius were obtained of ma weiter...

Author: Wilks DC, Winwood K, Gilliver SF, Kwiet A, Sun LW, Gutwasser C, Ferretti JL, Sargeant AJ, Felsenberg D, Rittweger J
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 236-46, PMID: 19949281
Keywords: Master Athletes
GID: 2084; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Age comparisons of bone density and geometry in men

Objectives: The purposes of this study were to examine tibia bone density and geometry in young and middle aged men, and to explore relationships between pQCT- and DXA-derived body composition variables. Method weiter...

Author: Sherk VD, Karabulut M, Bemben MG, Bemben DA
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 256-62, PMID: 19949283
GID: 2086; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Comparison of pQCT parameters between ulna and radius in retired elite gymnasts: the skeletal benefits associated with long-term gymnastics are bone- and site-specific

Objectives: To compare the skeletal benefits associated with gymnastics between ulna and radius. Methods: 19 retired artistic gymnasts, aged 18-36 years, were compared to 24 sedentary women. Bone mineral conten weiter...

Author: Ducher G, Hill BL, Angeli T, Bass SL, Eser P
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 247-55, PMID: 19949282
GID: 2085; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Muscle and bone adaptations after treadmill training in incomplete Spinal Cord Injury: a case study using peripheral Quantitative Computed Tomography

We describe the use of peripheral Quantitative Computed Tomography (pQCT) to identify musculoskeletal responses to partial body-weight supported treadmill training (BWSTT) in incomplete spinal cord injury (SCI) weiter...

Author: Coupaud S, Jack LP, Hunt KJ, Allan DB
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 288-97, PMID: 19949287
GID: 2087; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Normative values for maximum power during motor function assessment of jumping among physically active Japanese

Objectives: To determine the relationship between maximum power relative to body weight (Pmax-rel) and the aging process, and to indicate the target values of improvement of motor function in Japanese individua weiter...

Author: Tsubaki A, Kubo M, Kobayashi R, Jigami H, Takahashi HE
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 263-7, PMID: 19949284
Keywords: Leonardo Normative Data
GID: 2082; Last update: 02.12.2009
More information: Original Article

Scientific Publications (1992)

Skeletal adaptations during growth

NASA: The authors examine the role of mechanical usage in skeletal development. Principle mechanisms of bone physiology include longitudinal bone growth; modeling drifts; micromodeling; remodeling by the basic weiter...

Author: Jee WS, Frost HM
Source: Triangle., 1992; 31(2/3): 77-88, PMID: 11539347
GID: 2078; Last update: 25.11.2009

Scientific Publications (1998)

Perspectives: some roles of mechanical usage, muscle strength, and the mechanostat in skeletal physiology, disease, and research

Author: Frost HM, Ferretti JL, Jee WS
Source: Calcif Tissue Int., 1998; 62(1): 1-7, PMID: 9405724
GID: 2079; Last update: 25.11.2009

Research Studies (2007)

The "Functional Muscle-Bone Unit": probing the relevance of mechanical signals for bone development in children and adolescents

The present text deals with the relationship of muscle force and mass to bone mass and geometry in the developing skeleton of children and adolescents. Recent results of the last ten years are discussed with re weiter...

Author: Fricke O, Schoenau E
Source: Growth Horm IGF Res., 2007; 17(1): 1-9, PMID: 17194607
GID: 2076; Last update: 25.11.2009

Scientific Publications (1992)

The role of changes in mechanical usage set points in the pathogenesis of osteoporosis

Mechanical usage (MU) effects on modeling drifts and BMU-based remodeling affect bone mass in defined ways. Decreased MU stops additions of bone by modeling and increases removal of bone next to marrow by remod weiter...

Author: Frost HM
Source: J Bone Miner Res., 1992; 7(3): 253-61, PMID: 1585826
GID: 2077; Last update: 25.11.2009

Research Studies (2005)

Examining the developing skeletal muscle: Why, what and how

This review focuses on methodological concepts in the evaluation of skeletal muscle function, taking into account classical muscle physiology, the developing motor system in children and anthropometric paramete weiter...

Author: Fricke O, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2005; 5(3): 225-31, PMID: 16172513
GID: 2074; Last update: 25.11.2009
More information: Original Article

Research Studies (2002)

Einfluss von dynamischem Krafttraining mit und ohne Vibration auf Knochenmasse und -festigkeit bei postmenopausalen Frauen [Influence of Resistance Training with and without vibration on Bone Mass and Strength in Postmenopausal Women]

Einleitung: Das Skelettsystem unterliegt lebenslang einem regen Umbauprozess, bei dem sich Knochenmasse und -architektur der sich ändernden mechanischen Beanspruchung anpassen. Bei älteren Menschen liegen d weiter...

Author: Kleinmond C
Source: Dissertation, Medizinische Fakultät Charité, FU Berlin, 2002;
Keywords: Knochenmasse, Bone Mass, DXA, Spine,Vuibration Therapy
#GRFS118
GID: 1976; Last update: 08.10.2009
More information: Original Article

Research Studies (2006)

Der Voraussagewert von neuromuskulären Tests für das Sturzrisiko und das damit assoziierte Frakturrisiko bei postmenopausalen Frauen [Value of prediction of neuromuscular tests for risk of fall and the associated risk of fracture in postmenopausal women]

Die Voraussagekraft eines einzelnen Risikofaktors für das Vorhandensein einer Osteoporose ist relativ gering. Die Bemühungen zur Erstellung eines Risikoscores, der eine bestimmte Konstellation von Risikofakto weiter...

Author: Degner C
Source: Dissertation, 2006;
GID: 1981; Last update: 08.10.2009
More information: Original Article

Research Studies (2001)

Die Osteoporose des Mannes: Eine klinische Querschnittsanalyse [Osteoporosis in Men: A Clinical Cross Sectional Analysis]

Anhand eines Patientenkollektivs, das in einer Universitätsklinik einer großen mitteleuropäischen Hauptstadt in einem Zeitraum von dreieinhalb Jahren zur Knochendichtemessung überwiesen wurde, sollte ein kl weiter...

Author: Valentine SM
Source: Dissertation, 2001;
GID: 1983; Last update: 08.10.2009
More information: Original Article

Research Studies (2009)

Notwendigkeit und Wirksamkeit adjuvanter Schmerztherapie bei der Behandlung der primären Osteoporose und deren Einfluss auf die Lebensqualität [Influence of adjuvant pain medication on quality of life in the treatment of postmenopausal osteoporosis]

Der chronische Rückenschmerz ist das Hauptsymptom der postmenopausalen Osteoporose und mindert die Mobilität und Lebensqualität der Patientinnen. Die vorliegende prospektive, pseudorandomisierte Studie verg weiter...

Author: Ullrich H
Source: Dissertation Dissertation, 2009;
GID: 1982; Last update: 08.10.2009
More information: Original Article

Research Studies (2008)

Experimentelle und klinische Validierung der mittels peripherer Quantitativer Computertomographie (pQCT) berechneten biomechanischen Parameter Flächenträgheitsmoment I, Widerstandsmoment W und anderer Festigkeitsindices

Die Zielsetzung dieser Arbeit war die Überprüfung der Richtigkeit der Berechnung der Biegesteifigkeit peripherer Knochen mittels pQCT Messung und deren dichtebasierte Berechnung des Flächenträgheitsmomentes weiter...

Author: Beller GR
Source: Dissertation, 2008;
GID: 1974; Last update: 07.10.2009
More information: Original Article

Research Studies (2009)

Bone Loss and Recovery following prolonged microgravity exposure

Author: Fard-Shirazi Y, Kupke JS, Lucas MW, Greene ES, Swift JM, Thomson JV, Schepp BD, Bloomfield SA, Hogan HA
Source: ASBMR, 2009;
GID: 1955; Last update: 24.09.2009

Research Studies (2008)

Association between long-term consumption of soft drinks and variables of bone modeling and remodeling in a sample of healthy German children and adolescents

BACKGROUND: Soft drinks are thought to displace milk in diets of children and adolescents and therefore might affect variables of bone modeling and remodeling. OBJECTIVE: We assessed the association between lon weiter...

Author: Libuda L, Alexy U, Remer T, Stehle P, Schoenau E, Kersting M
Source: Am J Clin Nutr., 2008; 88(6): 1670-7, PMID: 19064530
GID: 1941; Last update: 22.09.2009

Research Studies (2009)

History of amenorrhoea compromises some of the exercise-induced benefits in cortical and trabecular bone in the peripheral and axial skeleton: a study in retired elite gymnasts

BACKGROUND: Female gymnasts frequently present with overt signs of hypoestrogenism, such as late menarche or menstrual dysfunction. The objective was to investigate the impact of history of amenorrhoea on the e weiter...

Author: Ducher G, Eser P, Hill B, Bass S
Source: Bone., 2009; 45(4): 760-7, PMID: 19573632
GID: 1922; Last update: 07.09.2009

Research Studies (2009)

Influence of exercise mode and osteogenic index on bone biomarker responses during short-term physical training

Prescribing exercise based on intensity, frequency, and duration of loading may maximize osteogenic responses in bone, but a model of the osteogenic potential of exercise has not been established in humans. In weiter...

Author: Lester ME, Urso ML, Evans RK, Pierce JR, Spiering BA, Maresh CM, Hatfield DL, Kraemer WJ, Nindl BC
Source: Bone., 2009; 45(4): 768-76, PMID: 19520194
GID: 1923; Last update: 07.09.2009

Scientific Publications (2008)

Mechanical influences on bone development in children

This review focuses on methodological concepts in the evaluation of skeletal muscle function and on adaptation. It is now thought that the critical property of bone is strength rather than weight, and that cont weiter...

Author: Schoenau E, Fricke O
Source: Eur J Endocrinol., 2008; 159 Suppl 1: S27-31, PMID: 18787052
GID: 1856; Last update: 28.07.2009
More information: Original Article

Scientific Publications (2008)

Local body composition is associated with gender differences of bone development at the forearm in puberty

BACKGROUND/AIMS: The present analyses intend to clarify if gender and puberty modify the relationship between bone development (modeling and remodeling) and fat mass at the forearm. METHODS: Data were collected weiter...

Author: Fricke O, Sumnik Z, Tutlewski B, Stabrey A, Remer T, Schoenau E
Source: Horm Res., 2008; 70(2): 105-11, PMID: 18547958
GID: 1857; Last update: 28.07.2009

Research Studies (2004)

Muscle mass during childhood--relationship to skeletal development

Bone densitometric data often are difficult to interpret in children and adolescents because of large inter- and intraindividual variations in bone size. Here, we propose a functional approach to bone densitome weiter...

Author: Schoenau E, Neu MC, Manz F
Source: J Musculoskelet Neuronal Interact., 2004; 4(1): 105-8, PMID: 15615084
GID: 1852; Last update: 27.07.2009
More information: Original Article

Research Studies (2009)

Assessment of material, structural, and functional properties of the human skeleton by pQCT systems

Peripheral quantitative computed tomography (pQCT) systems measure bone parameters noninvasively using low radiation doses. This limits image resolution but is practical for the diagnosis and quantitative monit weiter...

Author: Roldán EJ, Bogado CE
Source: Curr Osteoporos Rep., 2009; 7(2): 37-41, PMID: 19631026
GID: 1844; Last update: 27.07.2009

Research Studies (2008)

Bone mineral density alterations in upper and lower extremities 12 months after stroke measured by peripheral quantitative computed tomography and DXA.

To evaluate the loss of trabecular and cortical bone mineral density (BMD) and geometric parameters of bone strength expressed by stress-strain index (SSI) in the proximal and distal forearm and the alterations weiter...

Author: Lazoura O, Groumas N, Antoniadou E, Papadaki PJ, Papadimitriou A, Thriskos P, Fezoulidis I, Vlychou M.
Source: J Clin Densitom., 2008; 11(4):: 511-7, PMID: 18639477
GID: 1837; Last update: 21.07.2009

Research Studies (2009)

Influence of weight reduction on muscle performance and bone mass, structure and metabolism in obese premenopausal women.

Muscle performance, body composition and bone mass at the lumbar spine and proximal femur with DXA, structural traits at the tibia and radius with pQCT, and biomarkers of bone metabolism were assessed at baseli weiter...

Author: Uusi-Rasi K, Sievanen H, Kannus P, Pasanen M, Kukkonen-Harjula K, Fogelholm M
Source: J Musculoskelet Neuronal Interact, 2009; 9(2): 72-80, PMID: 19516082
GID: 1836; Last update: 21.07.2009
More information: Original Article

Research Studies (2009)

Intensity, repetitiveness, and directionality of habitual adolescent mobility patterns influence the tibial diaphysis morphology of athletes.

Mobility patterns affect the loads placed on the lower limbs during locomotion and may influence variation in lower limb diaphyseal robusticity and shape. This relationship commonly forms the basis for inferri weiter...

Author: Shaw CN, Stock JT
Source: Am J Phys Anthropol, 2009; 140(1): 149-59, PMID: 19358289
GID: 1811; Last update: 05.05.2009

Research Studies (2009)

Habitual throwing and swimming correspond with upper limb diaphyseal strength and shape in modern human athletes.

Variation in upper limb long bone cross-sectional properties may reflect a phenotypically plastic response to habitual loading patterns. Structural differences between limb bones have often been used to infer p weiter...

Author: Shaw CN, Stock JT
Source: Am J Phys Anthropol, 2009; 140(1): 160-72, PMID: 19358297
GID: 1812; Last update: 05.05.2009

Research Studies (2008)

Study of bone density by pQCT analysis in healthy adults and patients with B-thalassemia major and intermedia

BACKGROUND: Bone changes are a prominent symptom of beta-thalassemias, related to expansion of bone marrow and reduction of bone density. Conventional treatment ameliorates bone changes and improves survival, t weiter...

Author: Ladis V, Raptou P, Rigatou E, Chouliaras G, Galanos A, Korres D, Kattamis C
Source: Pediatr Endocrinol Rev., 2008; 6 Suppl 1: 127-31, PMID: 19360988
GID: 1804; Last update: 16.04.2009

Research Studies (2009)

Long-Term Leisure Time Physical Activity and Properties of Bone: A Twin Study

Abstract Effects of physical activity on bone properties when controlled for genetic effects are not fully understood. We aimed to investigate association between long-term leisure time physical activity (LTPA) weiter...

Author: Ma H, Leskinen T, Alen M, Cheng S, Sipilä S, Heinonen A, Kaprio J, Suominen H, Kujala UM
Source: J Bone Miner Res., 2009; 24/8: 1427-33, PMID: 19335223
GID: 1801; Last update: 16.04.2009

Research Studies (2009)

Bone mass and geometry of the tibia and the radius of master sprinters, middle and long distance runners, race-walkers and sedentary control participants: a pQCT study.

Mechanical loading is thought to be a determinant of bone mass and geometry. Both ground reaction forces and tibial strains increase with running speed. This study investigates the hypothesis that surrogates of weiter...

Author: Wilks DC, Winwood K, Gilliver SF, Kwiet A, Chatfield M, Michaelis I, Sun LW, Ferretti JL, Sargeant AJ, Felsenberg D, Rittweger J
Source: Bone, 2009; 45(1): 91-7, PMID: 19332164
GID: 1800; Last update: 16.04.2009

Research Studies (2009)

Recovery of muscle atrophy and bone loss from 90 days bed rest: results from a one-year follow-up

Earlier studies found the recovery of bone loss after clinical immobilization to be incomplete. It has been argued that this is due to the human skeleton"s inability to accrue bone mass once peak bone mass has weiter...

Author: Rittweger J, Felsenberg D
Source: Bone., 2009; 44(2): 214-24, PMID: 19022418
Keywords: BedRest
GID: 1734; Last update: 16.03.2009

Research Studies (2008)

Load-specific differences in the structure of femoral neck and tibia between world-class moguls skiers and slalom skiers

Bone structure of weight-bearing proximal femur and tibia was examined among the Finnish world-class moguls skiers and slalom skiers. We hypothesized that these bones, during typical sport-specific performance, weiter...

Author: Nikander R, Sievänen H, Heinonen A, Karstila T, Kannus P
Source: Scand J Med Sci Sports., 2008; 18(2): 145-53, PMID: 18067528
GID: 1733; Last update: 16.03.2009

Research Studies (2009)

Distal Radius Strength: A Comparison of DXA-Derived vs pQCT-Measured Parameters in Adolescent Females

Although quantitative computed tomography (QCT) is considered the gold standard for in vivo densitometry, dual-energy X-ray absorptiometry (DXA) scans assess larger bone regions and are more appropriate for ped weiter...

Author: Dowthwaite JN, Hickman RM, Kanaley JA, Ploutz-Snyder RJ, Spadaro JA, Scerpella TA
Source: J Clin Densitom., 2009; 12(1): 42-53, PMID: 19084448
GID: 1732; Last update: 12.03.2009

Research Studies (2008)

Body composition, volumetric and areal bone parameters in male-to-female transsexual persons

CONTEXT: Male-to-female (M-->F) transsexual persons undergo extreme changes in gonadal hormone concentrations, both by pharmacological and surgical interventions. Given the importance of sex steroids for develo weiter...

Author: Lapauw B, Taes Y, Simoens S, Van Caenegem E, Weyers S, Goemaere S, Toye K, Kaufman JM, T"Sjoen GG
Source: Bone., 2008; 43(6): 1016-21, PMID: 18835591
Keywords: transsexual, body composition, bone size
GID: 1727; Last update: 18.02.2009

Research Studies (2009)

Well-nourished cystic fibrosis patients have normal mineral density, but reduced cortical thickness at the forearm

SUMMARY: Our goal was to assess mineral density and geometry of the cortex at the level of the forearm in adolescents and young adults with cystic fibrosis, using peripheral quantitative computed tomography. We weiter...

Author: Louis O, Clerinx P, Gies I, De Wachter E, De Schepper J
Source: Osteoporos Int., 2009; 20(2): 309-14, PMID: 18536951
Keywords: cystic fibrosis bone geometry cortical thickness
GID: 1729; Last update: 18.02.2009

Research Studies (2009)

Beta-adrenergic blockade and leptin replacement effectively mitigate disuse bone loss

Our objective was to test effects of beta-adrenergic blockade on hindlimb unloading (HU)-induced bone loss and serum leptin and to compare these responses with those observed with leptin replacement. Adult male weiter...

Author: Baek K, Bloomfield SA
Source: J Bone Miner Res., 2009; 24(5): 792-9, PMID: 19113907
GID: 1725; Last update: 17.02.2009

Research Studies (2009)

Bone loss in the lower leg during 35 days of bed rest is predominantly from the cortical compartment.

Immobilization-induced bone loss is usually greater in the epiphyses than in the diaphyses. The larger fraction of trabecular bone in the epiphyses than in the diaphyses offers an intuitive explanation to acco weiter...

Author: Rittweger J, Simunic B, Bilancio G, De Santo NG, Cirillo M, Biolo G, Pisot R, Eiken O, Mekjavic IB, Narici M
Source: Bone, 2009; 44(4): 612-8, PMID: 19168165
Keywords: BedRest
GID: 1716; Last update: 17.02.2009

Research Studies (2009)

Serum estradiol is associated with volumetric BMD and modulates the impact of physical activity on bone size at the age of peak bone mass: a study in healthy male siblings.

This study investigates determinants of peak bone mass (PBM) in healthy men, focusing on effects and interactions of parameters reflecting mechanical loading and sex steroids. Healthy male siblings (n = 677; 2 weiter...

Author: Lapauw BM, Taes Y, Bogaert V, Vanbillemont G, Goemaere S, Zmierczak HG, De Bacquer D, Kaufman JM
Source: J Bone Miner Res, 2009; 24(6): 1075-85, PMID: 19113912
GID: 1724; Last update: 17.02.2009

Research Studies (2009)

A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6-19 years.

SUMMARY: We have produced paediatric reference data for forearm sites using the Stratec XCT-2000 peripheral quantitative computed tomography scanner. These data are intended for clinical and research use and w weiter...

Author: Ashby RL, Ward KA, Roberts SA, Edwards L, Mughal MZ, Adams JE
Source: Osteoporos Int, 2009; 20(8): 1337-46, PMID: 19066709
GID: 1726; Last update: 17.02.2009

Research Studies (2009)

Tibial geometry in individuals with neurofibromatosis type 1 without anterolateral bowing of the lower leg using peripheral quantitative computed tomography.

INTRODUCTION: Lower leg bowing with tibial pseudarthrosis is associated with neurofibromatosis type 1 (NF1). The objective of the study is to determine if the geometry of the lower limb in individuals with neur weiter...

Author: Stevenson DA, Viskochil DH, Carey JC, Slater H, Murray M, Sheng X, D"Astous J, Hanson H, Schorry E, Moyer-Mileur LJ
Source: Bone, 2009; 44(4): 585-9, PMID: 19118659
GID: 1722; Last update: 17.02.2009

Research Studies (2007)

Vertical jump performance after 90 days bed rest with and without flywheel resistive exercise, including a 180 days follow-up

Muscle atrophy and neuromuscular de-conditioning occur in response to space flight and bed-rest. In this study, we investigated the efficacy of flywheel training to conserve jumping power and height during 90 d weiter...

Author: Rittweger J, Felsenberg D, Maganaris C, Ferretti JL
Source: Eur J Appl Physiol., 2007; 100(4): 427-36, PMID: 17406887
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
GID: 1776; Last update: 06.02.2009

Research Studies (2009)

Sprint and endurance power and ageing: an analysis of master athletic world records

Human physical performance is notably reduced with ageing. Although the effects of ageing are often compounded by disuse, the study of master athletes provides an opportunity for investigating the effects of ag weiter...

Author: Rittweger J, di Prampero PE, Maffulli N, Narici MV
Source: Proc Biol Sci., 2009; 276(1657): 683-9, PMID: 18957366
GID: 1773; Last update: 06.02.2009

Research Studies (2008)

Changes in Volumetric Bone Density and Strength at the Tibial Midshaft in Boys and Girls during Growth

Author: Ahamed Y, Cooper D ML, Burrows M, Braid S, McKay H
Source: ASBMR, 2008;
Keywords: Children
GID: 1772; Last update: 28.01.2009
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Research Studies (2008)

Muscle-bone relationships in the lower leg of healthy pre-pubertal females and males

Muscle-bone relationships in healthy pre-pubertal children were investigated using four muscle measures as predictors of tibial strength: 66% tibia cross-sectional muscle area (CSMA) by pQCT; leg lean mass (LLM weiter...

Author: Binkley TL, Specker BL
Source: J Musculoskelet Neuronal Interact., 2008; 8(3): 239-43, PMID: 18799856
Keywords: Muscle-bone, Pre-pubertal, pQCT, Cross-sectional Muscle Area, Bone Strength
GID: 1690; Last update: 21.01.2009
More information: Original Article

Research Studies (2008)

Peripheral quantitative computed tomography of the proximal radius in young subjects - New reference data and interpretation of results

The aim of this contribution is to provide reference data for peripheral quantitative computed tomography (Stratec XCT2000(R)) performed at the proximal radius (the so-called "65% site") of young subjects and t weiter...

Author: Rauch F, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2008; 8(3): 217-26, PMID: 18799854
Keywords: Bone Geometry, Bone Mineral Density, Bone Size, Children, Peripheral Quantitative Computed Tomography
GID: 1689; Last update: 21.01.2009
More information: Original Article

Research Studies (2009)

Bone mass and structure in adolescents with type 1 diabetes compared to healthy peers

SUMMARY: We measured bone mass and structure using pQCT and DXA in adolescents with Type 1 diabetes and compared the results with those of healthy peers. Our results showed that diabetes is associated with redu weiter...

Author: Saha MT, Sievänen H, Salo MK, Tulokas S, Saha HH
Source: Osteoporos Int., 2009; 20(8): 1401-6, PMID: 19083073
Keywords: Adolescence . Bone fragility . Bone mineral content . Osteoporosis . Type 1 diabetes
GID: 1696; Last update: 21.01.2009

Research Studies (2008)

Strength indices from pQCT imaging predict up to 85% of variance in bone failure properties at tibial epiphysis and diaphysis

Our primary objective was to validate the Bone Strength Index for compression (BSIC) by determining the amount of variance in failure load and stiffness that was explained by BSIC and bone properties at two dis weiter...

Author: Kontulainen SA, Johnston JD, Liu D, Leung C, Oxland TR, McKay HA
Source: J Musculoskelet Neuronal Interact., 2008; 8(4): 401-9, PMID: 19147978
Keywords: pQCT, Strength Indices, Failure Load, Stiffness, Moment, Flexural Rigidity tibia, strength index
GID: 1691; Last update: 21.01.2009
More information: Original Article

Research Studies (2009)

The effects of high potassium consumption on bone mineral density in a prospective cohort study of elderly postmenopausal women

SUMMARY: Few studies have investigated the long-term effects of potassium intake on BMD. In a cohort of 266 elderly women, we found that baseline potassium intake as reflected by 24-hour urine potassium excreti weiter...

Author: Zhu K, Devine A, Prince RL
Source: Osteoporos Int., 2009; 20(2): 335-40, PMID: 18575949
Keywords: Bone mineral density . Dual energy x-ray absorptiometry . Elderly women . Peripheral quantitative computed tomography . Potassium . Trabecular bone
GID: 1695; Last update: 21.01.2009

Research Studies (2008)

Asymmetric bone adaptations to soleus mechanical loading after spinal cord injury

The purpose of this report is to examine longitudinal bone mineral density (BMD) changes in individuals with spinal cord injury (SCI) who began unilateral soleus electrical stimulation early after injury. Twelv weiter...

Author: Dudley-Javoroski S, Shields RK
Source: J Musculoskelet Neuronal Interact., 2008; 8(3): 227-38, PMID: 18799855
Keywords: Spinal chord injury, bone adaptation, Peripheral Quantitative Computed Tomography, Electrical Stimulation, Compression, Tension
GID: 1697; Last update: 21.01.2009
More information: Original Article

Research Studies (2009)

Contrast agent-enhanced computed tomography of articular cartilage: association with tissue composition and properties.

BACKGROUND: Contrast agent-enhanced computed tomography may enable the noninvasive quantification of glycosaminoglycan (GAG) content of articular cartilage. It has been reported that penetration of the negative weiter...

Author: Silvast TS, Jurvelin JS, Aula AS, Lammi MJ, Toyras J
Source: Acta Radiol, 2009; 50(1): 78-85, PMID: 19052932
GID: 1666; Last update: 12.12.2008

Research Studies (2008)

The effect of L-arginine administration on muscle force and power in postmenopausal women

Previously published data (J Bone Miner Res (2005); 20: 471) did not give evidence that the administration of the nitric oxide precursor L-arginine increases bone formation and decreases bone resorption in post weiter...

Author: Fricke O, Baecker N, Heer M, Tutlewski B, Schoenau E
Source: Clin Physiol Funct Imaging., 2008; 28(5): 307-11, PMID: 18510549
Keywords: cross-sectional muscle area; L-arginine; maximal isometric grip force; nitric oxide; peak jump force; peak jump power
GID: 1675; Last update: 12.12.2008

Research Studies (2006)

Musculoskeletal plasticity after acute spinal cord injury: effects of long-term neuromuscular electrical stimulation training

Maintaining the physiologic integrity of paralyzed limbs may be critical for those with spinal cord injury (SCI) to be viable candidates for a future cure. No long-term intervention has been tested to attempt t weiter...

Author: Shields RK, Dudley-Javoroski S
Source: J Neurophysiol., 2006; 95(4): 2380-90, PMID: 16407424
Keywords: spinal chord injury electrical stimulation
GID: 1676; Last update: 12.12.2008

Research Studies (2009)

Longitudinal Assessment of Bone Density and Structure in an Incident Cohort of Children With Crohn"s Disease

BACKGROUND & AIMS: The impact of childhood Crohn"s disease (CD) and its therapies on volumetric bone mineral density (vBMD), bone structure, and muscle mass have not been established. The objective of this long weiter...

Author: Dubner SE, Shults J, Baldassano RN, Zemel BS, Thayu M, Burnham JM, Herskovitz RM, Howard KM, Leonard MB
Source: Gastroenterology., 2009; 136: 123-130, PMID: 19026647
Keywords: bone geometry, Crohn, muscle children bone geometry
GID: 1670; Last update: 12.12.2008

Research Studies (2009)

Divergent Effects of Glucocorticoids on Cortical and Trabecular Compartment Bone Mineral Density in Childhood Nephrotic Syndrome

Abstract Glucocorticoid (GC) effects on skeletal development have not been established. The objective of this peripheral quantitative computed tomography (pQCT) study was to assess volumetric bone mineral densi weiter...

Author: Wetzsteon RJ, Shults J, Zemel BS, Gupta PU, Burnham JM, Herskovitz RM, Howard KM, Leonard MB
Source: J Bone Miner Res., 2009; 24(3):: 503-13, PMID: 19016583
GID: 1669; Last update: 12.12.2008

Research Studies (2009)

Vitamin D status and muscle function in post-menarchal adolescent girls

Context: There has been a resurgence of vitamin D deficiency among infants, toddlers and adolescents in the United Kingdom. Myopathy is an important clinical symptom of vitamin D deficiency, yet it has not been weiter...

Author: Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, Mughal Z
Source: J Clin Endocrinol Metab., 2009; 94(2): 559-563, PMID: 19033372
GID: 1674; Last update: 12.12.2008

Research Studies (2008)

Bone structure and volumetric BMD in overweight children: a longitudinal study

The effect of excess body fat on bone strength accrual is not well understood. Therefore, we assessed bone measures in healthy weight (HW) and overweight (OW) children. Children (9-11 yr) were classified as HW weiter...

Author: Wetzsteon RJ, Petit MA, Macdonald HM, Hughes JM, Beck TJ, McKay HA
Source: J Bone Miner Res., 2008; 23(12): 1946-53, PMID: 18684083
GID: 1655; Last update: 02.12.2008

Research Studies (2003)

Veränderungen der Knochenstruktur der Tibia, quantifiziert mit der pQCT, bei kleinwüchsigen Kindern und Jugendlichen unter Therapie mit Wachstumshormon

Als Prädiktoren für das Wachstum unter WH-Therapie werden auxiologische und laborchemische Parameter eingesetzt. Diese prospektive Studie evaluiert die Knochenstruktur der Tibia vor und während einer Therapi weiter...

Author: THOMAS SCHWAB
Source: Dissertation, 2003;
Keywords: children bone geometry, growth hormone
GID: 1597; Last update: 19.11.2008
More information: Original Article

Research Studies (1994)

The impact of degenerative spinal changes on the correlation of peripheral and axial bone density

Results of bone density measurements by quantitative computed tomography of the peripheral skeleton (pQCT) were compared with those of measurements at the axial skeleton with a view to study the effects of dege weiter...

Author: Schneider P, Börner W
Source: Nuklearmedizin., 1994; 33(4): 138-43, PMID: 7971288
Keywords: comparison axial peripheral bone density sensitivity
GID: 1636; Last update: 19.11.2008

Research Studies (1998)

Comparative assessment of bone mineral measurements using dual X-ray absorptiometry and peripheral quantitative computed tomography

A measurement of bone mass is the single most important determinant of future fracture. However, controversy exists as to which technique (dual X-ray absorptiometry (DXA) or peripheral quantitative computed tom weiter...

Author: Formica CA, Nieves JW, Cosman F, Garrett P, Lindsay R
Source: Osteoporos Int., 1998; 8(5): 460-7, PMID: 9850355
Keywords: Bone densitometry; Bone mineral density; Dual X-ray absorptiometry; Peripheral quantitative computed tomography
GID: 1615; Last update: 19.11.2008

Research Studies (2008)

Impact on bone of an estrogen receptor-alpha gene loss of function mutation

CONTEXT: The kindred described is the only known instance of a germ line loss of function mutation of estrogen receptor (ER)-alpha. OBJECTIVE: Our objective was to assess the impact of a loss of function mutati weiter...

Author: Smith EP, Specker B, Bachrach BE, Kimbro KS, Li XJ, Young MF, Fedarko NS, Abuzzahab MJ, Frank GR, Cohen RM, Lubahn DB, Korach KS
Source: J Clin Endocrinol Metab., 2008; 93(8): 3088-96, PMID: 18505767
Keywords: estrogen receptor gene
GID: 1571; Last update: 11.11.2008

Research Studies (2008)

Bone steady-state is established at reduced bone strength after spinal cord injury: a longitudinal study using peripheral quantitative computed tomography (pQCT)

Spinal cord injury (SCI) is associated with a marked and rapid sublesional bone loss. So far, reports about the time course of adaptive changes in bone mass and structure in people with chronic and complete SCI weiter...

Author: Frotzler A, Berger M, Knecht H, Eser P
Source: Bone., 2008; 43(3): 549-55, PMID: 18567554
Keywords: spinal chord injury bone strength
GID: 1577; Last update: 11.11.2008

Research Studies (2008)

Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions

The International Society for Clinical Densitometry (ISCD) has developed Official Positions for the clinical use of dual-energy X-ray absorptiometry (DXA) and non-DXA technologies. While only DXA can be used fo weiter...

Author: Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg D, Ito M, Prevrhal S, Hans DB, Lewiecki EM
Source: J Clin Densitom., 2008; 11(1): 123-62, PMID: 18442757
GID: 1537; Last update: 06.11.2008

Research Studies (2008)

BMD and bone geometry in transtibial and transfemoral amputees

Prolonged unloading of bone(s) in the residual limb after amputation may cause significant bone loss in the hip and distal bony end of the residual limb. The purpose of this study was to examine the effect of a weiter...

Author: Sherk VD, Bemben MG, Bemben DA
Source: J Bone Miner Res., 2008; 23(9): 1449-57, PMID: 18410229
GID: 1550; Last update: 06.11.2008

Research Studies (2008)

Improved peripheral cortical bone geometry after surgical treatment of primary hyperparathyroidism in postmenopausal women

CONTEXT: Cortical bone geometry is one of the most important components of bone strength. Excess endogenous PTH or intermittent PTH administration affects cortical bone geometry; however, the changes in cortica weiter...

Author: Kaji H, Yamauchi M, Nomura R, Sugimoto T
Source: J Clin Endocrinol Metab., 2008; 93(8): 3045-50, PMID: 18544624
Keywords: bone geometry, pth primary hyperparathyreoidism
GID: 1553; Last update: 06.11.2008

Research Studies (2008)

Tibial subchondral trabecular volumetric bone density in medial knee joint osteoarthritis using peripheral quantitative computed tomography technology

OBJECTIVE: Knee osteoarthritis (OA) is an organ-level failure of the joint involving pathologic changes in articular cartilage and bone. This cross-sectional study compared apparent volumetric bone mineral dens weiter...

Author: Bennell KL, Creaby MW, Wrigley TV, Hunter DJ
Source: Arthritis Rheum., 2008; 58(9): 2776-85, PMID: 18759296
GID: 1554; Last update: 06.11.2008

Research Studies (2008)

Tibial bone geometry in chronic stroke patients: influence of sex, cardiovascular health, and muscle mass

This study aimed to examine the geometry of the tibia in chronic stroke survivors. Fifty-five ambulatory individuals with chronic stroke were included in the study. pQCT was used to obtain a cross-sectional sca weiter...

Author: Pang MY, Ashe MC, Eng JJ
Source: J Bone Miner Res., 2008; 23(7): 1023-30, PMID: 18302505
Keywords: bone geometry, heart disease, muscle
GID: 1543; Last update: 06.11.2008

Research Studies (2008)

Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits

OBJECTIVE: To identify determinants of musculoskeletal deficits (muscle cross-sectional area [mCSA], trabecular volumetric bone mineral density [vBMD], and cortical bone strength [section modulus]) in patients weiter...

Author: Burnham JM, Shults J, Dubner SE, Sembhi H, Zemel BS, Leonard MB
Source: Arthritis Rheum., 2008; 58(8): 2518-27, PMID: 18668565
GID: 1548; Last update: 06.11.2008

Research Studies (2008)

Mechanographic characteristics of adolescents and young adults with congenital heart disease

The present study comprised 29 adolescents and young adults (15 females, 14 males; aged 14.1-23.9 years) with congenital heart disease (CHD) and focused on the interaction between the biomechanical system and C weiter...

Author: Fricke O, Witzel C, Schickendantz S, Sreeram N, Brockmeier K, Schoenau E
Source: Eur J Pediatr., 2008; 167(3): 331-6, PMID: 17516086
GID: 1559; Last update: 06.11.2008

Research Studies (2008)

Characterising cortical density in the mid-tibia: intra-individual variation in adolescent girls and boys

BACKGROUND: Inter-individual differences in cortical bone volumetric density (CoD), such as those related to sex, are a product of differences in remodelling rates. While cortical bone is often treated as a uni weiter...

Author: Cooper DM, Ahamed Y, Macdonald HM, McKay HA
Source: Br J Sports Med., 2008; 42(8): 690-5, PMID: 18635740
Keywords: Children, adolescents, cortical density
GID: 1547; Last update: 06.11.2008

Research Studies (2008)

Differences in physical fitness of male and female recruits in gender-integrated army basic training

PURPOSE: To evaluate gender differences in physical fitness before and after a 4-month gender-integrated basic training (BT) course and to determine whether this program effectively narrowed the differences bet weiter...

Author: Yanovich R, Evans R, Israeli E, Constantini N, Sharvit N, Merkel D, Epstein Y, Moran DS
Source: Med Sci Sports Exerc., 2008; 40(11 Suppl): S654-9, PMID: 18849869
GID: 1562; Last update: 06.11.2008

Research Studies (2007)

Long-bone changes after pamidronate discontinuation in children and adolescents with osteogenesis imperfecta

Cyclical intravenous pamidronate is a widely used symptomatic therapy in moderate to severe osteogenesis imperfecta (OI). The effects of treatment discontinuation on long bone development have not been characte weiter...

Author: Rauch F, Cornibert S, Cheung M, Glorieux FH
Source: Bone., 2007; 40(4): 821-7, PMID: 17223617
Keywords: bisphosphonates, children, adolescents, osteogenesis imperfecta
GID: 1532; Last update: 26.09.2008

Research Studies (2008)

Bone Volumetric Density, Geometry and Strength in Female and Male Collegiate Runners

Author: Thiescafer AJ, Hughes JM, Popp KL, Wetzsteon RJ, Stovitz SD, Kaufman BC, Kurzer MS, Petit MA
Source: ASBMR, 2008;
GID: 1533; Last update: 26.09.2008
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Research Studies (2008)

Jumping Mechanography Safely Evaluates Muscle Performance in Older Adults

Neuromuscular function declines with advancing age and is strongly associated with increased risk for falls, hip fractures and decreased quality of life. A variety of tests, e.g., chair-rise or timed-up-and-go, weiter...

Author: Buehring B, Valentine S, Woods A, Checovich M, Krueger D, Binkley N
Source: ASBMR 2008, 2008;
GID: 1529; Last update: 19.09.2008
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Research Studies (2008)

Imaging of lower extremity stress fracture injuries

Stress reactions and stress fractures in the lower extremities occur frequently in military and athletic populations. As the clinical symptoms of stress fracture may mimic other less severe musculoskeletal inju weiter...

Author: Moran DS, Evans RK, Hadad E
Source: Sports Med., 2008; 38(4): 345-56, PMID: 18348592
Keywords: fatigue
GID: 1505; Last update: 09.09.2008

Research Studies (2008)

Genetic and environmental influence on structural strength of weight-bearing and non-weight-bearing bone: a twin study

A bivariate genetic analysis among 217 older female twin pairs showed that, although the structural strength of tibia and radius are mainly regulated by same genetic and environmental factors, the tibia is more weiter...

Author: Mikkola TM, Sipilä S, Rantanen T, Sievänen H, Suominen H, Kaprio J, Koskenvuo M, Kauppinen M, Heinonen A
Source: J Bone Miner Res., 2008; 23(4): 492-8, PMID: 18072876
Keywords: twins, genetics, bone geometry
GID: 1510; Last update: 09.09.2008

Research Studies (2008)

Longitudinal changes in BMD and bone geometry in a population-based study

We prospectively examined vBMD and structural bone parameters assessed by QCT among participants of the InCHIANTI study over a 6-yr follow-up. Periosteal apposition occurred both in men and women. Endocortical weiter...

Author: Lauretani F, Bandinelli S, Griswold ME, Maggio M, Semba R, Guralnik JM, Ferrucci L
Source: J Bone Miner Res., 2008; 23(3): 400-8, PMID: 17997708
Keywords: longitudinal study, osteoporosis, periosteal apposition, endocortical resorption, BMD, bone geometry
GID: 1506; Last update: 09.09.2008

Research Studies (2008)

Muscle function improves during growth hormone therapy in short children born small for gestational age: results of a peripheral quantitative computed tomography study on body composition

BACKGROUND: Short small for gestational age (SGA) children can be affected by a lack of muscle mass rather than fat mass. They also face a high risk of the metabolic syndrome developing after childhood. It is n weiter...

Author: Schweizer R, Martin DD, Schönau E, Ranke MB
Source: J Clin Endocrinol Metab., 2008; 93(8): 2978-83, PMID: 18505766
Keywords: muscle groth hormone, growth retardation
GID: 1515; Last update: 09.09.2008

Research Studies (2008)

In vivo magnetic resonance detects rapid remodeling changes in the topology of the trabecular bone network after menopause and the protective effect of estradiol

INTRODUCTION: Estrogen depletion after menopause is accompanied by bone loss and architectural deterioration of trabecular bone. The hypothesis underlying this work is that the microMRI-based virtual bone biops weiter...

Author: Wehrli FW, Ladinsky GA, Jones C, Benito M, Magland J, Vasilic B, Popescu AM, Zemel B, Cucchiara AJ, Wright AC, Song HK, Saha PK, Peachey H, Snyder PJ
Source: J Bone Miner Res., 2008; 23(5): 730-40, PMID: 18251704
Keywords: MRI, bone structure, estrogen
GID: 1511; Last update: 09.09.2008

Research Studies (2006)

Comparison of the skeletal effects of the progestogens desogestrel and levonorgestrel in oral contraceptive preparations in young women: controlled, open, partly randomized investigation over 13 cycles

AIM: This 12-month study was conducted to evaluate the skeletal effects of two monophasic oral contraceptives containing 20 mug of ethinylestradiol and 100 mug of levonorgestrel (LEVO) or 150 mug of desogestrel weiter...

Author: Hartard M, Kleinmond C, Luppa P, Zelger O, Egger K, Wiseman M, Weissenbacher ER, Felsenberg D, Erben RG
Source: Contraception., 2006; 74(5): 367-75, PMID: 17046377
GID: 1516; Last update: 09.09.2008

Research Studies (2008)

Glucocorticoid excess affects cortical bone geometry in premenopausal, but not postmenopausal, women

Glucocorticoid (GC) excess causes a great increase in fracture risk, but the effects of GC excess on cortical bone geometry are unknown. The present study was performed to examine the effects of GC excess on co weiter...

Author: Kaji H, Yamauchi M, Chihara K, Sugimoto T
Source: Calcif Tissue Int., 2008; 82(3): 182-90, PMID: 18278571
Keywords: cortisone, bone geometry
GID: 1376; Last update: 22.07.2008

Research Studies (2008)

Whole body vibration in cystic fibrosis - a pilot study

Introduction: In cystic fibrosis (CF), bone mass deficits as well as a lack of muscle mass and force have been described. The bone mass deficits are thought to be at least in part secondary to the reduced muscl weiter...

Author: Roth J, Wust M, Rawer R, Schnabel D, Armbrecht G, Beller G, Rembitzki I, Wahn U, Felsenberg D, Staab D
Source: J Musculoskelet Neuronal Interact., 2008; 8(2): 179-87, PMID: 18622087
Keywords: Cystic Fibrosis, Whole Body Vibration, Bone, Muscle, Mechanography
#GRFS126
GID: 1382; Last update: 22.07.2008
More information: Original Article

Research Studies (2008)

Osteoporosis in men

With the aging of the population, there is a growing recognition that osteoporosis and fractures in men are a significant public health problem, and both hip and vertebral fractures are associated with increase weiter...

Author: Khosla S, Amin S, Orwoll E
Source: Endocr Rev., 2008; 29(4): 441-64, PMID: 18451258
GID: 1381; Last update: 22.07.2008

Research Studies (2008)

Effects of Depot medroxyprogesterone acetate on bone density and bone metabolism before and after peak bone mass: a case-control study

INTRODUCTION: Depot medroxyprogesterone acetate (DMPA; Depo-Provera, Tadworth, UK) contraception is used by more than 9 million women worldwide and has a high usage among teenagers in the United Kingdom and the weiter...

Author: Walsh JS, Eastell R, Peel NF
Source: J Clin Endocrinol Metab., 2008; 93(4): 1317-23, PMID: 18230659
Keywords: Estrogen, hormones
GID: 1380; Last update: 22.07.2008

Research Studies (2008)

Relationship between endogenous parathyroid hormone and bone metabolism/geometry in female patients treated with glucocorticoid

Although the role of PTH (parathyroid hormone) has been debated in glucocorticoid (GC)-induced osteoporosis (GIO), clinical data about the relation of endogenous PTH to bone metabolism in patients treated with weiter...

Author: Kaji H, Yamauchi M, Chihara K, Sugimoto T
Source: Horm Metab Res., 2008; 40(1): 60-5, PMID: 18072075
Keywords: pth, cortisone, hormone
GID: 1377; Last update: 22.07.2008

Research Studies (2007)

Bone size normalizes with age in children and adolescents with type 1 diabetes

OBJECTIVE: The aim of this study was to establish whether type 1 diabetes has a long-term effect on bone development in children and adolescents. RESEARCH DESIGN AND METHODS: Bone characteristics and muscle cro weiter...

Author: Bechtold S, Putzker S, Bonfig W, Fuchs O, Dirlenbach I, Schwarz HP
Source: Diabetes Care., 2007; 30(8): 2046-50, PMID: 17456838
Keywords: children, adolescents, bone geometry, diabetes
GID: 1379; Last update: 22.07.2008

Research Studies (2008)

High-volume FES-cycling partially reverses bone loss in people with chronic spinal cord injury

Spinal cord injury (SCI) leads to severe bone loss in the paralysed limbs and to a resulting increased fracture risk thereof. Since long bone fractures can lead to comorbidities and a reduction in quality of li weiter...

Author: Frotzler A, Coupaud S, Perret C, Kakebeeke TH, Hunt KJ, Donaldson Nde N, Eser P
Source: Bone., 2008; 43(1): 169-76, PMID: 18440891
GID: 1374; Last update: 22.07.2008

Research Studies (2008)

Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD

In postmenopausal women with a wide range of vertebral deformities, MRI-based structural measures of topology and scale at the distal radius are shown to account for as much as 30% of vertebral deformity, indep weiter...

Author: Ladinsky GA, Vasilic B, Popescu AM, Wald M, Zemel BS, Snyder PJ, Loh L, Song HK, Saha PK, Wright AC, Wehrli FW
Source: J Bone Miner Res., 2008; 23(1): 64-74, PMID: 17784842
GID: 1373; Last update: 22.07.2008

Research Studies (2008)

Fat infiltration in muscle: new evidence for familial clustering and associations with diabetes.

OBJECTIVE: Increased fat infiltration in skeletal muscle has been associated with diabetes. Quantitative computed tomography (QCT) can be used to measure muscle density, which reflects the lipid content of skel weiter...

Author: Miljkovic-Gacic I, Wang X, Kammerer CM, Gordon CL, Bunker CH, Kuller LH, Patrick AL, Wheeler VW, Evans RW, Zmuda JM
Source: Obesity (Silver Spring), 2008; 16(8): 1854-60, PMID: 18535552
Keywords: fat, muscle
GID: 1378; Last update: 22.07.2008

Research Studies (2008)

The rate of muscle temperature increase during acute whole-body vibration exercise

This study compared the rate of muscle temperature (T (m)) increase during acute whole-body vibration (WBV), to that of stationary cycling and passive warm-up. Additionally we wanted to determine if the purport weiter...

Author: Cochrane DJ, Stannard SR, Sargeant AJ, Rittweger J
Source: Eur J Appl Physiol., 2008; 103(4): 441-8, PMID: 18392845
Keywords: Muscle Temperature Power
#GRFS137
GID: 1310; Last update: 05.05.2008

Research Studies (2008)

Decline of specific peak jumping power with age in master runners

Background: It is difficult to disentangle the effects of pure ageing from those of disuse. Master athletes, however, provide an opportunity to assess the effects of ageing per se, as these people maintain high weiter...

Author: Michaelis I, Kwiet A, Gast U, Boshof A, Antvorskov T, Jung T, Rittweger J, Felsenberg D
Source: J Musculoskelet Neuronal Interact., 2008; 8(1): 64-70, PMID: 18398267
Keywords: Power
GID: 1309; Last update: 05.05.2008
More information: Original Article

Research Studies (2007)

Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study

SUMMARY: We studied the relations between bone geometry and density and the mechanical properties of human cadaveric tibiae. Bone geometry, assessed by MRI and pQCT, and bone density, assessed by DXA, were sign weiter...

Author: Liu D, Manske SL, Kontulainen SA, Tang C, Guy P, Oxland TR, McKay HA
Source: Osteoporos Int., 2007; 18(7): 991-7, PMID: 17268944
GID: 1267; Last update: 06.03.2008

Research Studies (2007)

Musculoskeletal abnormalities of the tibia in juvenile rheumatoid arthritis

OBJECTIVE: To characterize local bone geometry, density, and strength, using peripheral quantitative computed tomography (pQCT), compared with general bone characteristics as measured using dual x-ray absorptio weiter...

Author: Felin EM, Prahalad S, Askew EW, Moyer-Mileur LJ
Source: Arthritis Rheum., 2007; 56(3): 984-94, PMID: 17328076
GID: 1265; Last update: 06.03.2008

Research Studies (1998)

Volumetric bone density and geometry assessed by peripheral quantitative computed tomography in uremic patients on maintenance hemodialysis

The aim of this study was to establish, by means of peripheral quantitative computed tomography (pQCT) at the distal radius, the existence of cortical and/or trabecular osteopenia, and to assess the integrity o weiter...

Author: Russo CR, Taccetti G, Caneva P, Mannarino A, Maranghi P, Ricca M
Source: Osteoporos Int., 1998; 8(5): 443-8, PMID: 9850352
GID: 1268; Last update: 06.03.2008

Research Studies (2007)

Impaired geometric properties of tibia in older women with hip fracture history

SUMMARY: This study evaluated side-to-side differences in tibial mineral mass and geometry in women with previous hip fracture sustained on average 3.5 years earlier. Both tibial mineral mass and geometry were weiter...

Author: Mikkola T, Sipilä S, Portegijs E, Kallinen M, Alén M, Kiviranta I, Pekkonen M, Heinonen A
Source: Osteoporos Int., 2007; 18(8): 1083-90, PMID: 17323107
GID: 1264; Last update: 06.03.2008

Research Studies (2007)

Analyzing cortical bone cross-sectional geometry by peripheral QCT: comparison with bone histomorphometry

A distinct advantage of peripheral quantitative computed tomography (pQCT) is its ability to assess bone strength by measuring cross-sectional geometry and density of cortical bone. For accurate determination o weiter...

Author: Kontulainen S, Liu D, Manske S, Jamieson M, Sievänen H, McKay H
Source: J Clin Densitom., 2007; 10(1): 86-92, PMID: 17289530
GID: 1266; Last update: 06.03.2008

Research Studies (2007)

Calcium supplementation and weight bearing physical activity--do they have a combined effect on the bone density of pre-pubertal children

The adaptation of bone to exercise has been shown to be modified by dietary calcium intake. The aim of this randomised controlled trial was to investigate whether there was a differential response to calcium su weiter...

Author: Ward KA, Roberts SA, Adams JE, Lanham-New S, Mughal MZ
Source: Bone., 2007; 41(4): 496-504, PMID: 17870038
GID: 1263; Last update: 06.03.2008

Research Studies (2007)

Association between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD study

In this large population-based study in young men, we show that the COMT val158met polymorphism modulates the association between physical activity, aBMD (DXA), and trabecular vBMD (pQCT). INTRODUCTION: Peak BM weiter...

Author: Lorentzon M, Eriksson AL, Nilsson S, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2007; 22(8): 1165-72, PMID: 17451372
GID: 1274; Last update: 06.03.2008

Research Studies (2007)

Relationship of volumetric bone mineral density and structural parameters with ERalpha gene polymorphisms

Bone mineral density (BMD) contributes to bone strength, and methods for clinical assessment of bone quality characteristics beyond what can be gathered by BMD are awaited. Peripheral quantitative computed tomo weiter...

Author: Cepollaro C, Lauretani F, Gozzini A, Masi L, Falchetti A, Del Monte F, Carbonell-Sala S, Tanini A, Corsi AM, Bandinelli S, Ferrucci L, Brandi ML
Source: Calcif Tissue Int., 2007; 80(5): 307-15, PMID: 17505773
GID: 1259; Last update: 06.03.2008

Research Studies (2007)

Annual change in bone mineral density in predialysis patients with chronic renal failure: significance of a decrease in serum 1,25-dihydroxy-vitamin D

Bone disease occurs in the predialysis phase of chronic renal failure (CRF). The aim of this study was to examine how a decrease in renal function affects annual bone mineral density (BMD) changes in predialysi weiter...

Author: Obatake N, Ishimura E, Tsuchida T, Hirowatari K, Naka H, Imanishi Y, Miki T, Inaba M, Nishizawa Y
Source: J Bone Miner Metab., 2007; 25(1): 74-9, PMID: 17187197
GID: 1262; Last update: 06.03.2008

Research Studies (2007)

Hand dominance and bone response after a distal radial fracture: a peripheral QCT study

There are no reports on bone geometry or volumetric bone density adaptations in those who have sustained a distal radial fracture. We used peripheral quantitative computed tomography (pQCT) and dual-energy X-ra weiter...

Author: Ashe MC, Khan KM, Davis JC, Guy P, McKay HA
Source: J Clin Densitom., 2007; 10(1): 93-101, PMID: 17289531
GID: 1270; Last update: 06.03.2008

Research Studies (2007)

Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration

OBJECTIVE: To determine the interrelations between degenerative changes in articular cartilage and underlying trabecular bone during development of osteoarthritis and to test the ability of quantitative magneti weiter...

Author: Lammentausta E, Kiviranta P, Töyräs J, Hyttinen MM, Kiviranta I, Nieminen MT, Jurvelin JS
Source: Osteoarthritis Cartilage., 2007; 15(10): 1149-57, PMID: 17502160
GID: 1272; Last update: 06.03.2008

Research Studies (2008)

Chocolate consumption and bone density in older women

BACKGROUND: Nutrition is important for the development and maintenance of bone structure and for the prevention of osteoporosis and fracture. The relation of chocolate intake with bone has yet to be investigate weiter...

Author: Hodgson JM, Devine A, Burke V, Dick IM, Prince RL
Source: Am J Clin Nutr., 2008; 87(1): 175-80, PMID: 18175753
GID: 1271; Last update: 06.03.2008

Research Studies (2006)

Leptin is a negative independent predictor of areal BMD and cortical bone size in young adult Swedish men

The association between leptin and areal BMD has been controversial, and the predictive role of leptin on cortical volumetric BMD and bone size has not previously been studied. We show that leptin is a negative weiter...

Author: Lorentzon M, Landin K, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2006; 21(12): 1871-8, PMID: 17002557
GID: 1252; Last update: 06.03.2008

Research Studies (2006)

Polymorphisms in the aromatase gene predict areal BMD as a result of affected cortical bone size: the GOOD study

The association between aromatase gene polymorphisms, bone parameters, and sex steroid levels was studied in 1068 men (18.9 +/- 0.6 years of age). Several aromatase gene polymorphisms were found to be associate weiter...

Author: Lorentzon M, Swanson C, Eriksson AL, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2006; 21(2): 332-9, PMID: 16418790
GID: 1251; Last update: 06.03.2008

Research Studies (2005)

Growth patterns at distal radius and tibial shaft in pubertal girls: a 2-year longitudinal study

Bone changes, in terms of both size and BMD, were assessed longitudinally in pubertal girls. Before puberty, BMD at the distal radius declined, whereas bone size increased, suggesting that normal growing girls weiter...

Author: Wang Q, Alén M, Nicholson P, Lyytikäinen A, Suuriniemi M, Helkala E, Suominen H, Cheng S
Source: J Bone Miner Res., 2005; 20(6): 954-61, PMID: 15883635
GID: 1248; Last update: 06.03.2008

Research Studies (2007)

Can bisphosphonate treatment be stopped in a growing child with skeletal fragility

SUMMARY: Cyclical pamidronate therapy in a 2-year-old child with skeletal fragility resulted in remodelling of vertebral fractures and improvement in bone mineral density (BMD) at distal radial and spinal sites weiter...

Author: Ward KA, Adams JE, Freemont TJ, Mughal MZ
Source: Osteoporos Int., 2007; 18(8): 1137-40, PMID: 17279467
GID: 1269; Last update: 06.03.2008

Research Studies (2005)

Males have larger skeletal size and bone mass than females, despite comparable body size

Gender differences in fractures may be related to body size, bone size, geometry, or density. We studied this in 18-year-old males (n = 36) and females (n = 36) matched for height and weight. Despite comparable weiter...

Author: Nieves JW, Formica C, Ruffing J, Zion M, Garrett P, Lindsay R, Cosman F
Source: J Bone Miner Res., 2005; 20(3): 529-35, PMID: 15746999
GID: 1246; Last update: 06.03.2008

Research Studies (2005)

Examining bone surfaces across puberty: a 20-month pQCT trial

This follow-up study assessed sex differences in cortical bone growth at the tibial midshaft across puberty. In both sexes, periosteal apposition dominated over endosteal resorption. Boys had a greater magnitud weiter...

Author: Kontulainen SA, Macdonald HM, Khan KM, McKay HA
Source: J Bone Miner Res., 2005; 20(7): 1202-7, PMID: 15940373
GID: 1249; Last update: 06.03.2008

Research Studies (2005)

Age of attainment of peak bone mass is site specific in Swedish men--The GOOD study

Results from this study suggest that PBM has been attained in the spine and femoral neck, but not in the radius or tibia, in 18- to 20-year-old men, in which an endosteal contraction and increase in cortical vo weiter...

Author: Lorentzon M, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2005; 20(7): 1223-7, PMID: 15940376
GID: 1250; Last update: 06.03.2008

Research Studies (2007)

Is a school-based physical activity intervention effective for increasing tibial bone strength in boys and girls

This 16-month randomized, controlled school-based study compared change in tibial bone strength between 281 boys and girls participating in a daily program of physical activity (Action Schools! BC) and 129 same weiter...

Author: Macdonald HM, Kontulainen SA, Khan KM, McKay HA
Source: J Bone Miner Res., 2007; 22(3): 434-46, PMID: 17181400
GID: 1253; Last update: 06.03.2008

Research Studies (2007)

Growth in early life predicts bone strength in late adulthood: the Hertfordshire Cohort Study

Infant growth is a determinant of adult bone mass, and poor childhood growth is a risk factor for adult hip fracture. Peripheral quantitative computed tomography (pQCT) allows non-invasive assessment of bone st weiter...

Author: Oliver H, Jameson KA, Sayer AA, Cooper C, Dennison EM, Hertfordshire Cohort Study Group
Source: Bone., 2007; 41(3): 400-5, PMID: 17599849
GID: 1256; Last update: 06.03.2008

Research Studies (2007)

Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y)

CONTEXT: Sex steroids are involved in the regulation of pubertal cortical bone expansion in males. In vitro studies have indicated that the enzyme uridine diphosphate glucuronosyltransferase (UGT) 2B7 has the c weiter...

Author: Swanson C, Lorentzon M, Vandenput L, Labrie F, Rane A, Jakobsson J, Chouinard S, Bélanger A, Ohlsson C
Source: J Clin Endocrinol Metab., 2007; 92(9): 3697-704, PMID: 17579197
GID: 1255; Last update: 06.03.2008

Research Studies (2007)

Forearm bone geometry and mineral content in UK women of European and South-Asian origin

Ethnic variation in areal bone mineral density (BMD) has been well documented. Such variation may, however, reflects differences in bone geometry rather than volumetric BMD (vBMD). The aim of the study was to c weiter...

Author: Ward KA, Roy DK, Pye SR, O"Neill TW, Berry JL, Swarbrick CM, Silman AJ, Adams JE
Source: Bone., 2007; 41(1): 117-21, PMID: 17493888
GID: 1260; Last update: 06.03.2008

Research Studies (2007)

Genetic and environmental determinants of volumetric and areal BMD in multi-generational families of African ancestry: the Tobago Family Health Study

BMD is higher and fracture risk is lower among individuals of African versus European descent, but little is known about the genetic architecture of BMD in the former group. Heritabilities of areal and volumetr weiter...

Author: Wang X, Kammerer CM, Wheeler VW, Patrick AL, Bunker CH, Zmuda JM
Source: J Bone Miner Res., 2007; 22(4): 527-36, PMID: 17227221
GID: 1254; Last update: 06.03.2008

Research Studies (2007)

Quantifying leisure physical activity and its relation to bone density and strength

PURPOSE: Compare three published methods of quantifying physical activity (total activity, peak strain, and bone-loading exposure (BLE) scores) and identify their associations with areal bone mineral density (a weiter...

Author: Shedd KM, Hanson KB, Alekel DL, Schiferl DJ, Hanson LN, Van Loan MD
Source: Med Sci Sports Exerc., 2007; 39(12): 2189-98, PMID: 18046190
GID: 1277; Last update: 06.03.2008

Research Studies (2007)

Age-related decline in trabecular and cortical density: a 5-year peripheral quantitative computed tomography follow-up study of pre- and postmenopausal women

This 5-year prospective study assessed changes in trabecular and cortical volumetric bone density at the non-weight-bearing radius and weight-bearing tibia among clinically healthy pre- and postmenopausal women weiter...

Author: Uusi-Rasi K, Sievänen H, Pasanen M, Kannus P
Source: Calcif Tissue Int., 2007; 81(4): 249-53, PMID: 17768589
GID: 1278; Last update: 06.03.2008

Research Studies (2007)

Similar effects of long-term exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestational-age (SGA) children

BACKGROUND AND AIMS: Treatment with GH in short children has focused on height development. Little is known about the concomitant changes in muscle mass, bone structure and bone strength. METHODS: Muscle area a weiter...

Author: Schweizer R, Martin DD, Haase M, Roth J, Trebar B, Binder G, Schwarze CP, Ranke MB
Source: Bone., 2007; 41(5): 875-81, PMID: 17826368
GID: 1276; Last update: 06.03.2008

Research Studies (2006)

Determinants of bone mass and bone size in a large cohort of physically active young adult men

The determinants of bone mineral density (BMD) at multiple sites were examined in a fit college population. Subjects were 755 males (mean age = 18.7 years) entering the United States Military Academy. A questio weiter...

Author: Ruffing JA, Cosman F, Zion M, Tendy S, Garrett P, Lindsay R, Nieves JW
Source: Nutr Metab (Lond)., 2006; 3: 14, PMID: 16480509
GID: 1219; Last update: 05.03.2008
More information: Original Article

Research Studies (2006)

Effects of joint unloading and reloading on human cartilage morphology and function, muscle cross-sectional areas, and bone density - a quantitative case report

Recent studies have shown that thinning of human cartilage occurs with unloading, but no data are available on the effect of remobilization (after immobilization) on knee joint cartilage status in humans. We ex weiter...

Author: Hudelmaier M, Glaser C, Hausschild A, Burgkart R, Eckstein F
Source: J Musculoskelet Neuronal Interact., 2006; 6(3): 284-90, PMID: 17142951
GID: 1208; Last update: 05.03.2008
More information: Original Article

Research Studies (2006)

Bone loss from the human distal tibia epiphysis during 24 days of unilateral lower limb suspension

Bone loss during immobilization is well documented. Currently, the only means of studying this in human beings is bed rest, which is resource intensive and inconvenient for the subjects. Unilateral lower limb s weiter...

Author: Rittweger J, Winwood K, Seynnes O, de Boer M, Wilks D, Lea R, Rennie M, Narici M
Source: J Physiol., 2006; 577(Pt 1): 331-7, PMID: 17023509
GID: 1210; Last update: 05.03.2008

Research Studies (2006)

Bone adaptation to altered loading after spinal cord injury: a study of bone and muscle strength

Bone loss from the paralysed limbs after spinal cord injury (SCI) is well documented. Under physiological conditions, bones are adapted to forces which mainly emerge from muscle pull. After spinal cord injury ( weiter...

Author: Rittweger J, Gerrits K, Altenburg T, Reeves N, Maganaris CN, de Haan A
Source: J Musculoskelet Neuronal Interact., 2006; 6(3): 269-76, PMID: 17142949
GID: 1207; Last update: 05.03.2008
More information: Original Article

Research Studies (2007)

A multi-component exercise regimen to prevent functional decline and bone fragility in home-dwelling elderly women: randomized, controlled trial

Summary: This study showed that combination of strength, balance, agility and jumping training prevented functional decline and bone fragility in home-dwelling elderly women. The finding supports the idea that weiter...

Author: Karinkanta S, Heinonen A, Sievänen H, Uusi-Rasi K, Pasanen M, Ojala K, Fogelholm M, Kannus P
Source: Osteoporos Int., 2007; 18(4): 453-62, PMID: 17103296
GID: 1245; Last update: 05.03.2008

Research Studies (2006)

Device-specific thresholds to diagnose osteoporosis at the proximal femur: an approach to interpreting peripheral bone measurements in clinical practice

INTRODUCTION: A single T score criterion cannot be universally applied to different peripheral bone measurement devices, since measurements in an identical population result in a tenfold difference in the preva weiter...

Author: Clowes JA, Peel NF, Eastell R
Source: Osteoporos Int., 2006; 17(9): 1293-302, PMID: 16810454
GID: 1243; Last update: 05.03.2008

Research Studies (2005)

High parity is associated with increased bone size and strength

Some, but not all, studies report an association between decreased hip fracture risk and high parity despite similar bone mineral density (BMD). Our hypothesis was that bone size, a major determinant of bone st weiter...

Author: Specker B, Binkley T
Source: Osteoporos Int., 2005; 16(12): 1969-74, PMID: 16091837
GID: 1241; Last update: 05.03.2008

Research Studies (2006)

A 19-week exercise program for people with chronic stroke enhances bone geometry at the tibia: a peripheral quantitative computed tomography study

BACKGROUND: We assessed the impact of a 19-week exercise program on bone health in chronic stroke. RESULTS: Those who underwent the program reported significantly more gain in tibial trabecular bone content weiter...

Author: Pang MY, Ashe MC, Eng JJ, McKay HA, Dawson AS
Source: Osteoporos Int., 2006; 17(11): 1615-25, PMID: 16896509
GID: 1244; Last update: 05.03.2008

Research Studies (2006)

Long-term recreational gymnastics provides a clear benefit in age-related functional decline and bone loss. A prospective 6-year study

INTRODUCTION: Bone fragility and decreased functional performance are risk factors for osteoporotic fractures. The influence of long-term recreational gymnastics on the maintenance of bone rigidity and physical weiter...

Author: Uusi-Rasi K, Sievänen H, Heinonen A, Vuori I, Beck TJ, Kannus P
Source: Osteoporos Int., 2006; 17(8): 1154-64, PMID: 16758134
GID: 1242; Last update: 05.03.2008

Research Studies (1999)

Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group

To determine whether magnetic resonance (MR)-derived measures of trabecular bone architecture in the distal radius are predictive for prevalent hip fractures, 20 subjects with hip fractures and 19 age-matched p weiter...

Author: Majumdar S, Link TM, Augat P, Lin JC, Newitt D, Lane NE, Genant HK
Source: Osteoporos Int., 1999; 10(3): 231-9, PMID: 10525716
GID: 1230; Last update: 05.03.2008

Research Studies (2007)

Skeletal effects of long-term estrogen and testosterone replacement treatment in a man with congenital aromatase deficiency: evidences of a priming effect of estrogen for sex steroids action on bone

The relative contribution of each sex steroid (i.e. estrogen and androgen) on bone in men and the relationships among sex steroids and changes in BMD and bone strength are still unknown. A defective BMD of bone weiter...

Author: Rochira V, Zirilli L, Madeo B, Aranda C, Caffagni G, Fabre B, Montangero VE, Roldan EJ, Maffei L, Carani C
Source: Bone., 2007; 40(6): 1662-8, PMID: 17400043
GID: 1224; Last update: 05.03.2008

Research Studies (2007)

Influence of birth weight and early diet on peripheral bone in premenopausal Cambridge women: a pQCT study

Epidemiological studies have shown relationships of adult bone mineral status with birth weight and diet in early life. Most of these studies used DXA to measure bone mineral content. Peripheral quantitative co weiter...

Author: Laskey MA, de Bono S, Smith EC, Prentice A
Source: J Musculoskelet Neuronal Interact., 2007; 7(1): 83, PMID: 17396013
GID: 1215; Last update: 05.03.2008
More information: Original Article

Research Studies (2006)

Bone density comparison of selected carpal and tarsal bones: validation for their use in compression fracture fixation studies of scaphoid screws

INTRODUCTION: To determine if trabecular, total and cortical bone densities of the capitate, navicular, cuboid, and first cuneiform were equivalent to those of the scaphoid, such that these bones could be used weiter...

Author: Brutus JP, Rajkumar JS, Rust E, Harley BJ, Palmer AK, Werner FW
Source: Chir Main., 2006; 25(2): 77-80, PMID: 16841768
GID: 1226; Last update: 05.03.2008

Research Studies (2007)

Detrimental effect of oral contraceptives on parameters of bone mass and geometry in a cohort of 248 young women

The aim of this cross-sectional analysis was to examine the skeletal effects of low-dose monophasic oral contraceptive (OC) use in a cohort of 248 young Caucasian women aged 18-24 years. Areal bone mineral dens weiter...

Author: Hartard M, Kleinmond C, Wiseman M, Weissenbacher ER, Felsenberg D, Erben RG
Source: Bone., 2007; 40(2): 444-50, PMID: 16965947
GID: 1220; Last update: 05.03.2008

Research Studies (2007)

Vitamin D status and bone mass in UK South Asian women

INTRODUCTION: Low vitamin D status is prevalent among South Asians living in the UK. The relationship, however, between serum 25-hydroxyvitamin D level (25OHD), serum parathyroid level (PTH) and bone mass in th weiter...

Author: Roy DK, Berry JL, Pye SR, Adams JE, Swarbrick CM, King Y, Silman AJ, O"Neill TW
Source: Bone., 2007; 40(1): 200-4, PMID: 16950669
GID: 1221; Last update: 05.03.2008

Research Studies (2004)

Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus

OBJECTIVE: To determine whether bone characteristics in adolescents with type 1 diabetes mellitus (DM) are influenced by blood glucose regulation and disease duration. The subjects were adolescents with type 1 weiter...

Author: Heap J, Murray MA, Miller SC, Jalili T, Moyer-Mileur LJ
Source: J Pediatr., 2004; 144(1): 56-62, PMID: 14722519
GID: 1209; Last update: 05.03.2008

Research Studies (2005)

Musculoskeletal and functional muscle-bone analysis in children with rheumatic disease using peripheral quantitative computed tomography

Bone demineralization is a severe complication of juvenile idiopathic arthritis (JIA) and other rheumatic diseases. To identify patients, who are at risk of bone disease, musculoskeletal analysis is performed. weiter...

Author: Bechtold S, Ripperger P, Dalla Pozza R, Schmidt H, Häfner R, Schwarz HP
Source: Osteoporos Int., 2005; 16(7): 757-63, PMID: 15490121
GID: 1239; Last update: 05.03.2008

Research Studies (2005)

The discriminative ability of peripheral and axial bone measurements to identify proximal femoral, vertebral, distal forearm and proximal humeral fractures: a case control study

Previous studies evaluating peripheral bone measurement devices have often used discontinued technologies, compared single devices, only evaluated a single fracture syndrome or failed to make a comparison with weiter...

Author: Clowes JA, Eastell R, Peel NF
Source: Osteoporos Int., 2005; 16(12): 1794-802, PMID: 15947861
GID: 1240; Last update: 05.03.2008

Research Studies (2005)

Assessment of anthropometric, systemic, and lifestyle factors influencing bone status in the legs of spinal cord injured individuals

The aim of the present study was to assess the influence of muscle spasms, systemic or lifestyle factors on bone mass and geometry of the femur and the tibia in people with long-standing spinal cord injury (SCI weiter...

Author: Eser P, Frotzler A, Zehnder Y, Schiessl H, Denoth J
Source: Osteoporos Int., 2005; 16(1): 26-34, PMID: 15138665
GID: 1235; Last update: 05.03.2008

Research Studies (2001)

Bone loss in patients with untreated chronic obstructive pulmonary disease is mediated by an increase in bone resorption associated with hypercapnia

This study sought to determine whether the bone loss in untreated chronic obstructive pulmonary disease (COPD) is associated with hypercapnia and/or respiratory acidosis. Bone mineral density (BMD) measured at weiter...

Author: Dimai HP, Domej W, Leb G, Lau KH
Source: J Bone Miner Res., 2001; 16(11): 2132-41, PMID: 11697811
GID: 1234; Last update: 05.03.2008

Research Studies (2001)

Lasofoxifene (CP-336,156) protects against the age-related changes in bone mass, bone strength, and total serum cholesterol in intact aged male rats

The purpose of this study was to evaluate if long-term (6 months) treatment with lasofoxifene (LAS), a new selective estrogen receptor modulator (SERM), can protect against age-related changes in bone mass and weiter...

Author: Ke HZ, Qi H, Chidsey-Frink KL, Crawford DT, Thompson DD
Source: J Bone Miner Res., 2001; 16(4): 765-73, PMID: 11316005
GID: 1233; Last update: 05.03.2008

Research Studies (2003)

Bone density measurements in pediatric patients with renal osteodystrophy

Peripheral quantitative computed tomography (pQCT) can selectively measure the densities of cortical and trabecular bone, but there is limited information about its use in patients with renal osteodystrophy. Th weiter...

Author: Lima EM, Goodman WG, Kuizon BD, Gales B, Emerick A, Goldin J, Salusky IB
Source: Pediatr Nephrol., 2003; 18(6): 554-9, PMID: 12712376
GID: 1229; Last update: 05.03.2008

Research Studies (2006)

Evaluation of cortical bone by peripheral quantitative computed tomography in continuous ambulatory peritoneal dialysis patients

Several studies have suggested an increased prevalence of osteopenia in dialysis. Peripheral quantitative computed tomography (pQCT) is a new technique that allows the noninvasive evaluation of trabecular and c weiter...

Author: Negri AL, Barone R, Lombas C, Bogado CE, Zanchetta JR
Source: Hemodial Int., 2006; 10(4): 351-5, PMID: 17014510
GID: 1225; Last update: 05.03.2008

Research Studies (2006)

Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study

BACKGROUND: Frailty is a common condition in elders and identifies a state of vulnerability for adverse health outcomes. OBJECTIVE: Our objective was to provide a biological face validity to the well-establishe weiter...

Author: Cesari M, Leeuwenburgh C, Lauretani F, Onder G, Bandinelli S, Maraldi C, Guralnik JM, Pahor M, Ferrucci L
Source: Am J Clin Nutr., 2006; 83(5): 1142-8, PMID: 16685058
GID: 1227; Last update: 05.03.2008

Research Studies (2005)

High and low density in the same bone: a study on children and adolescents with mild osteogenesis imperfecta

Children and adolescents with osteogenesis imperfecta (OI) generally have low bone mineral density (BMD) at the lumbar spine and hip. However, the effects of the disease on diaphyseal bone have not been well ch weiter...

Author: Rauch F, Land C, Cornibert S, Schoenau E, Glorieux FH
Source: Bone., 2005; 37(5): 634-41, PMID: 16112635
GID: 1228; Last update: 05.03.2008

Research Studies (2006)

Loading modalities and bone structures at nonweight-bearing upper extremity and weight-bearing lower extremity: a pQCT study of adult female athletes

This cross-sectional study of adult female athletes assessed whether the apparent loading-related differences in bone structure are primarily associated with the loading type or the muscle performance-related j weiter...

Author: Nikander R, Sievänen H, Uusi-Rasi K, Heinonen A, Kannus P
Source: Bone., 2006; 39(4): 886-94, PMID: 16731064
GID: 1205; Last update: 05.03.2008
More information: Original Article

Research Studies (2005)

Evaluation of cortical bone by peripheral quantitative computed tomography in renal transplant recipients

BACKGROUND: The absolute risk of fractures in renal transplant patients is 3 times that of matched controls. Most of the symptomatic fractures are peripheral, suggesting a greater compromise of cortical bone. P weiter...

Author: Negri AL, Lombas C, Cuevas C, Schiavelli R, Bogado CE, Zanchetta JR
Source: Transplant Proc., 2005; 37(2): 1020-2, PMID: 15848610
GID: 1204; Last update: 05.03.2008

Scientific Publications (2006)

Measurement of bone density and bone strength with pQCT

Author: J. Willnecker
Source: Novel approaches towards primate toxicology, 2006; 13 - 19
GID: 1213; Last update: 05.03.2008
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Research Studies (2007)

Smoking is associated with lower bone mineral density and reduced cortical thickness in young men

CONTEXT: Smoking has previously been associated with reduced areal bone mineral density (aBMD) in elderly subjects, but the association remains controversial in adolescents. OBJECTIVE: The aim of this study was weiter...

Author: Lorentzon M, Mellström D, Haug E, Ohlsson C
Source: J Clin Endocrinol Metab., 2007; 92(2): 497-503, PMID: 17077132
GID: 1212; Last update: 05.03.2008

Research Studies (2007)

High bone mineral density in pycnodysostotic patients with a novel mutation in the propeptide of cathepsin K

INTRODUCTION: Pycnodysostosis is typically associated with short stature, multiple fractures without adequate trauma and high bone density on x-ray. The increased bone density is due to a genetic defect of cath weiter...

Author: Schilling AF, Mülhausen C, Lehmann W, Santer R, Schinke T, Rueger JM, Amling M
Source: Osteoporos Int., 2007; 18(5): 659-69, PMID: 17206399
GID: 1211; Last update: 05.03.2008

Research Studies (2007)

Volumetric bone mineral density and bone size in sleep-deprived individuals

INTRODUCTION: Chronic sleep deprivation, which is associated with several age-related pathologies and altered endocrine function, may adversely affect bone. Our a priori hypothesis was that bone mineral density weiter...

Author: Specker BL, Binkley T, Vukovich M, Beare T
Source: Osteoporos Int., 2007; 18(1): 93-9, PMID: 16909195
GID: 1223; Last update: 05.03.2008

Research Studies (2007)

Effects of genes, sex, age, and activity on BMC, bone size, and areal and volumetric BMD

Quantitative genetic analyses of bone data for 710 inter-related individuals 8-85 yr of age found high heritability estimates for BMC, bone area, and areal and volumetric BMD that varied across bone sites. Acti weiter...

Author: Havill LM, Mahaney MC, L Binkley T, Specker BL
Source: J Bone Miner Res., 2007; 22(5): 737-46, PMID: 17444815
GID: 1222; Last update: 05.03.2008

Research Studies (2001)

Oral glucocorticoid-induced fall in cortical bone volume and density in postmenopausal asthmatic patients

Despite a deepening understanding of the influence of glucocorticoids (GC) on trabecular bone, little is known about GC-induced cortical bone loss. To elucidate the mechanism of GC-induced loss of cortical bone weiter...

Author: Tsugeno H, Goto B, Fujita T, Okamoto M, Mifune T, Mitsunobu F, Ashida K, Hosaki Y, Tsuji T, Tanizaki Y
Source: Osteoporos Int., 2001; 12(4): 266-70, PMID: 11420775
GID: 1231; Last update: 05.03.2008

Research Studies (2007)

Bone loss and mechanical properties of tibia in spinal cord injured men

AIM: The effects of Spinal Cord Injury (SCI) on bone in paralyzed areas are well documented but there are few data for the importance of the level of injury in the decrease of mechanical strength in paralyzed l weiter...

Author: Dionyssiotis Y, Trovas G, Galanos A, Raptou P, Papaioannou N, Papagelopoulos P, Petropoulou K, Lyritis GP
Source: J Musculoskelet Neuronal Interact., 2007; 7(1): 62-8, PMID: 17396008
GID: 1217; Last update: 05.03.2008
More information: Original Article

Research Studies (2005)

Reduced bone mineral density in adults treated with high-dose corticosteroids for childhood nephrotic syndrome

BACKGROUND: Children with minimal change nephrotic syndrome (MCNS) receive repeated courses of high dose oral prednisolone. No previous study has investigated the impact of this on final bone mineral density (B weiter...

Author: Hegarty J, Mughal MZ, Adams J, Webb NJ
Source: Kidney Int., 2005; 68(5): 2304-9, PMID: 16221233
GID: 1186; Last update: 04.03.2008

Research Studies (2005)

Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial

BACKGROUND: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. OBJECTI weiter...

Author: Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F
Source: Am J Clin Nutr., 2005; 82(5): 1115-26; quiz 1147-8, PMID: 16280447
GID: 1185; Last update: 04.03.2008

Research Studies (2006)

Structural adaptations to bone loss in aging men and women

INTRODUCTION: Bone apposition on the subperiosteal surface and bone loss from the endocortical surface during aging establish the external diameter, total cross-sectional area (tCSA), cortical thickness (Ct.Th) weiter...

Author: Russo CR, Lauretani F, Seeman E, Bartali B, Bandinelli S, Di Iorio A, Guralnik J, Ferrucci L
Source: Bone., 2006; 38(1): 112-8, PMID: 16242391
GID: 1187; Last update: 04.03.2008

Research Studies (2006)

Accuracy of pQCT for evaluating the aged human radius: an ashing, histomorphometry and failure load investigation

INTRODUCTION: Quantifying the determinants of bone strength is essential to understanding if or how the structure will fail under load. Determining failure requires knowledge of material and geometric propertie weiter...

Author: Ashe MC, Khan KM, Kontulainen SA, Guy P, Liu D, Beck TJ, McKay HA
Source: Osteoporos Int., 2006; 17(8): 1241-51, PMID: 16683179
GID: 1188; Last update: 04.03.2008

Research Studies (2005)

Association of amount of physical activity with cortical bone size and trabecular volumetric BMD in young adult men: the GOOD study

In this population-based study, amount of PA was associated with cortical bone size (increased thickness and periosteal circumference) and trabecular vBMD, but not with cortical vBMD or length of the long bones weiter...

Author: Lorentzon M, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2005; 20(11): 1936-43, PMID: 16234966
GID: 1193; Last update: 04.03.2008

Research Studies (2006)

Cortical pQCT measures are associated with fractures in dialysis patients

To determine if pQCT could identify HD patients with fractures, we conducted a cross-sectional study in 52 men and women on HD. We found that cortical, but not trabecular, pQCT measures were associated with fra weiter...

Author: Jamal SA, Gilbert J, Gordon C, Bauer DC
Source: J Bone Miner Res., 2006; 21(4): 543-8, PMID: 16598374
GID: 1191; Last update: 04.03.2008

Research Studies (2006)

Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study

The importance of pubertal timing for adult BMD in males was studied through association of pubertal timing with young adult bone phenotype. Pubertal timing was found to predict both cortical and trabecular vol weiter...

Author: Kindblom JM, Lorentzon M, Norjavaara E, Hellqvist A, Nilsson S, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2006; 21(5): 790-5, PMID: 16734395
GID: 1189; Last update: 04.03.2008

Research Studies (2006)

Change in cortical bone density and its distribution differs between boys and girls during puberty

CONCEPT: Postmenarchal girls and premenopausal women have 3-4% higher cortical bone density (CoD, milligrams per cubic centimeter), compared with postpubertal boys and men, respectively. Females" denser cortica weiter...

Author: Kontulainen SA, Macdonald HM, McKay HA
Source: J Clin Endocrinol Metab., 2006; 91(7): 2555-61, PMID: 16636118
GID: 1192; Last update: 04.03.2008

Research Studies (2005)

The state of pediatric bone: summary of the ASBMR pediatric bone initiative

Author: Klein GL, Fitzpatrick LA, Langman CB, Beck TJ, Carpenter TO, Gilsanz V, Holm IA, Leonard MB, Specker BL, ASBMR Group
Source: J Bone Miner Res., 2005; 20(12): 2075-81, PMID: 16294260
GID: 1195; Last update: 04.03.2008

Research Studies (2006)

Magnesium and muscle performance in older persons: the InCHIANTI study

BACKGROUND: The role of magnesium in maintaining muscle integrity and function in older adults is largely unknown. OBJECTIVE: We aimed to investigate the relation between serum magnesium concentrations and musc weiter...

Author: Dominguez LJ, Barbagallo M, Lauretani F, Bandinelli S, Bos A, Corsi AM, Simonsick EM, Ferrucci L
Source: Am J Clin Nutr., 2006; 84(2): 419-26, PMID: 16895893
GID: 1196; Last update: 04.03.2008

Research Studies (2005)

Effects of age, grip strength and smoking on forearm volumetric bone mineral density and bone geometry by peripheral quantitative computed tomography: comparisons between female and male

Peripheral quantitative computed tomography (pQCT) is useful to measure volumetric bone mineral density (vBMD) distinguishing trabecular from cortical bones as well as quantity of bone geometry. In the present weiter...

Author: Kaji H, Kosaka R, Yamauchi M, Kuno K, Chihara K, Sugimoto T
Source: Endocr J., 2005; 52(6): 659-66, PMID: 16410656
GID: 1203; Last update: 04.03.2008

Research Studies (2005)

Intravenous bisphosphonate therapy increases radial width in adults with osteogenesis imperfecta

Neridronate therapy in adult patients with OI significantly increases the cross-sectional area of the proximal radius. This observation may provide an additional explanation for the antifracture efficacy of bis weiter...

Author: Gatti D, Viapiana O, Lippolis I, Braga V, Prizzi R, Rossini M, Adami S
Source: J Bone Miner Res., 2005; 20(8): 1323-6, PMID: 16007328
GID: 1190; Last update: 04.03.2008

Research Studies (2006)

Changes in bone mass and bone turnover following tibial shaft fracture

INTRODUCTION: Bone loss occurs in the regional bone following tibial shaft fracture. An earlier cross-sectional study showed that measurements made at the metaphyseal region of the tibia using peripheral quanti weiter...

Author: Veitch SW, Findlay SC, Hamer AJ, Blumsohn A, Eastell R, Ingle BM
Source: Osteoporos Int., 2006; 17(3): 364-72, PMID: 16362144
GID: 1199; Last update: 04.03.2008

Research Studies (2006)

Correlates of bone quality in older persons

PURPOSE OF THE STUDY: In a population-based sample of older persons, we studied the relationship between tibial bone density and geometry and factors potentially affecting osteoporosis. METHODS: Of the 1260 par weiter...

Author: Lauretani F, Bandinelli S, Russo CR, Maggio M, Di Iorio A, Cherubini A, Maggio D, Ceda GP, Valenti G, Guralnik JM, Ferrucci L
Source: Bone., 2006; 39(4): 915-21, PMID: 16709469
GID: 1202; Last update: 04.03.2008

Research Studies (2006)

COL1A1 Sp1 polymorphism associates with bone density in early puberty

Optimal acquisition of bone mass in puberty is a key determinant of the lifetime risk of osteoporosis and has a strong genetic basis. We investigated the relationship between the COL1A1 Sp1 polymorphism and BMD weiter...

Author: Suuriniemi M, Kovanen V, Mahonen A, Alén M, Wang Q, Lyytikäinen A, Cheng S
Source: Bone., 2006; 39(3): 591-7, PMID: 16580273
GID: 1201; Last update: 04.03.2008

Research Studies (2005)

Free testosterone is a positive, whereas free estradiol is a negative, predictor of cortical bone size in young Swedish men: the GOOD study

In this study, we evaluated the predictive roles of sex steroids for skeletal parameters in young men (n = 1068) at the age of peak bone mass. Serum free estradiol was a negative predictor, whereas free testost weiter...

Author: Lorentzon M, Swanson C, Andersson N, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2005; 20(8): 1334-41, PMID: 16007330
GID: 1194; Last update: 04.03.2008

Research Studies (2006)

A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency

CONTEXT: Low bone mass is a characteristic feature of the adult GH deficiency (GHD) syndrome, but recent dual-energy x-ray absorptiometry (DXA) studies in patients with GH-receptor and GHRH-receptor gene mutati weiter...

Author: Murray RD, Adams JE, Shalet SM
Source: J Clin Endocrinol Metab., 2006; 91(2): 432-8, PMID: 16278268
GID: 1197; Last update: 04.03.2008

Research Studies (2006)

Effect of protein supplementation during a 6-month strength and conditioning program on areal and volumetric bone parameters

BACKGROUND: Skeletal loading and proper nutrition are necessary for optimal bone health. The appropriate amount of dietary protein to maximize skeletal health, however, is under constant debate. OBJECTIVE: To d weiter...

Author: Ballard TL, Specker BL, Binkley TL, Vukovich MD
Source: Bone., 2006; 38(6): 898-904, PMID: 16364710
GID: 1198; Last update: 04.03.2008

Research Studies (2005)

Quantitative bone analysis in children: current methods and recommendations

Over the past decade there have been an increasing number of published manuscripts dealing with pediatric bone mineral density (BMD). The reason for this interest is 2-fold. First, there is a belief that bone g weiter...

Author: Specker BL, Schoenau E
Source: J Pediatr., 2005; 146(6): 726-31, PMID: 15973307
GID: 1166; Last update: 03.03.2008

Research Studies (2005)

Case-control study of the muscular compartments and osseous strength in neurofibromatosis type 1 using peripheral quantitative computed tomography

Skeletal anomalies are observed in neurofibromatosis type 1 (NF1), but the pathogenesis is unknown. Given that muscle mass is important in the development of the strength of bone, peripheral quantitative comput weiter...

Author: Stevenson DA, Moyer-Mileur LJ, Carey JC, Quick JL, Hoff CJ, Viskochil DH
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 145-9, PMID: 15951630
GID: 1163; Last update: 03.03.2008
More information: Original Article

Research Studies (2005)

L-arginine, the natural precursor of NO, is not effective for preventing bone loss in postmenopausal women

NO is an important regulator of bone turnover. L-Arginine, the natural precursor of NO, can enhance NO production. However, no effect of L-arginine hydrochloride supplementation was found on bone metabolism or weiter...

Author: Baecker N, Boese A, Schoenau E, Gerzer R, Heer M
Source: J Bone Miner Res., 2005; 20(3): 471-9, PMID: 15746992
GID: 1168; Last update: 03.03.2008

Research Studies (2005)

Fracture threshold in the femur and tibia of people with spinal cord injury as determined by peripheral quantitative computed tomography

OBJECTIVE: To determine bone traits of the femur and tibia with peripheral quantitative computed tomography (pQCT) that best distinguish between spinal cord injury (SCI) subjects with and without fractures. DES weiter...

Author: Eser P, Frotzler A, Zehnder Y, Denoth J
Source: Arch Phys Med Rehabil., 2005; 86(3): 498-504, PMID: 15759235
GID: 1169; Last update: 03.03.2008

Research Studies (2005)

Bone geometry and density in the skeleton of pre-pubertal gymnasts and school children

We have studied the differences between the peripheral and axial skeleton of pre-pubertal gymnasts and controls. We hypothesised that compared to controls, gymnasts would have larger and stronger radius and tib weiter...

Author: Ward KA, Roberts SA, Adams JE, Mughal MZ
Source: Bone., 2005; 36(6): 1012-8, PMID: 15876561
GID: 1173; Last update: 03.03.2008

Research Studies (2005)

Bone loss is detected more frequently in patients with ankylosing spondylitis with syndesmophytes

OBJECTIVE: To define the relationship between bone growth (syndesmophytes) and bone loss (osteoporosis) in ankylosing spondylitis (AS). METHODS: Bone mineral density (BMD) at the spine, hip, and radius was meas weiter...

Author: Karberg K, Zochling J, Sieper J, Felsenberg D, Braun J
Source: J Rheumatol., 2005; 32(7): 1290-8, PMID: 15996067
GID: 1178; Last update: 03.03.2008

Research Studies (2005)

Differences in peak bone mass in women of European and South Asian origin can be explained by differences in body size

There are few data concerning the occurrence of peak bone mass in women of South Asian origin. The aim of this study was to determine the level of peak bone mass in South Asian women in the UK and to determine weiter...

Author: Roy D, Swarbrick C, King Y, Pye S, Adams J, Berry J, Silman A, O"Neill T
Source: Osteoporos Int., 2005; 16(10): 1254-62, PMID: 15702264
GID: 1179; Last update: 03.03.2008

Research Studies (2005)

Maturity- and sex-related changes in tibial bone geometry, strength and bone-muscle strength indices during growth: a 20-month pQCT study

During growth, bone strength is conferred through subtle adaptations in bone mass and geometry in response to muscle forces. Few studies have examined the changes in bone geometry, strength and the bone-muscle weiter...

Author: Macdonald HM, Kontulainen SA, Mackelvie-O"Brien KJ, Petit MA, Janssen P, Khan KM, McKay HA
Source: Bone., 2005; 36(6): 1003-11, PMID: 15823517
GID: 1175; Last update: 03.03.2008

Research Studies (2005)

Digital radiogrammetry as a new diagnostic tool for estimation of disease-related osteoporosis in rheumatoid arthritis compared with pQCT

OBJECTIVES: To investigate the potential of a new osteogeometric technology based on digital X-ray radiogrammetry (DXR) as a diagnostic tool for quantification of severity-dependent osteoporosis, and to disting weiter...

Author: Böttcher J, Pfeil A, Heinrich B, Lehmann G, Petrovitch A, Hansch A, Heyne JP, Mentzel HJ, Malich A, Hein G, Kaiser WA
Source: Rheumatol Int., 2005; 25(6): 457-64, PMID: 15761729
GID: 1180; Last update: 03.03.2008

Research Studies (2005)

Bone measurements by peripheral quantitative computed tomography (pQCT) in children with cerebral palsy

OBJECTIVE: To use peripheral quantitative computed tomography (pQCT) to determine bone measurements in patients with cerebral palsy (CP) age 3 to 20 years and compare them with control subjects. STUDY DESIGN: A weiter...

Author: Binkley T, Johnson J, Vogel L, Kecskemethy H, Henderson R, Specker B
Source: J Pediatr., 2005; 147(6): 791-6, PMID: 16356433
GID: 1182; Last update: 03.03.2008

Research Studies (2005)

Bone structure and volumetric density in young adults born prematurely: a peripheral quantitative computed tomography study

Prematurity is known to be associated with reduced bone mineral density (BMD) in childhood, but whether this condition has long-term detrimental consequences on adult bone structure is not known. In this study, weiter...

Author: Backström MC, Kuusela AL, Koivisto AM, Sievänen H
Source: Bone., 2005; 36(4): 688-93, PMID: 15780965
GID: 1174; Last update: 03.03.2008

Research Studies (2005)

A cybernetic approach to osteoporosis in anorexia nervosa

A group of 25 female individuals, who had been admitted to the University Hospital with the diagnosis of anorexia nervosa (AN) 3 to 10 years before, was seen for a follow-up visit in the hospital. These women g weiter...

Author: Fricke O, Tutlewski B, Stabrey A, Lehmkuhl G, Schöenau E
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 155-61, PMID: 15951632
GID: 1165; Last update: 03.03.2008
More information: Original Article

Research Studies (2005)

Muscle atrophy and bone loss after 90 days" bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study

Muscle atrophy and bone loss pose substantial problems for long-term space flight and in clinical immobilization. We therefore tested the efficacy of flywheel resistive exercise and pamidronate to counteract su weiter...

Author: Rittweger J, Frost HM, Schiessl H, Ohshima H, Alkner B, Tesch P, Felsenberg D
Source: Bone., 2005; 36(6): 1019-29, PMID: 15811637
Keywords: Flywheel BedRest
GID: 1176; Last update: 03.03.2008

Research Studies (2005)

Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children

BACKGROUND: Protein and alkalizing minerals are increasingly described as playing a major role in influencing bone status, not only in the elderly but also in children and adolescents. OBJECTIVE: We examined wh weiter...

Author: Alexy U, Remer T, Manz F, Neu CM, Schoenau E
Source: Am J Clin Nutr., 2005; 82(5): 1107-14, PMID: 16280446
GID: 1181; Last update: 03.03.2008

Research Studies (2004)

Rural versus nonrural differences in BMC, volumetric BMD, and bone size: a population-based cross-sectional study

Despite reports of lower fracture risk among rural versus urban populations, few studies have investigated rural versus urban differences in bone mineral content (BMC) and bone mineral density (BMD). Population weiter...

Author: Specker B, Binkley T, Fahrenwald N
Source: Bone., 2004; 35(6): 1389-98, PMID: 15589221
GID: 1153; Last update: 29.02.2008

Research Studies (2002)

Mechanical strength of the proximal femur as predicted from geometric and densitometric bone properties at the lower limb versus the distal radius

This experimental study compares geometric and densitometric properties of cortical and trabecular bone at the lower limb and the distal radius with those at the femoral neck, and evaluates their ability to pre weiter...

Author: Lochmüller EM, Groll O, Kuhn V, Eckstein F
Source: Bone., 2002; 30(1): 207-16, PMID: 11792587
GID: 1156; Last update: 29.02.2008

Research Studies (2005)

Association of an aromatase TTTA repeat polymorphism with circulating estrogen, bone structure, and biochemistry in older women

Osteoporosis is a disease that is strongly genetically determined. Aromatase converts androgens to estradiol in postmenopausal women, therefore polymorphisms of the gene for this enzyme may be associated with b weiter...

Author: Dick IM, Devine A, Prince RL
Source: Am J Physiol Endocrinol Metab., 2005; 288(5): E989-95, PMID: 15613678
GID: 1159; Last update: 29.02.2008

Research Studies (2004)

Increased periosteal circumference remains present 12 months after an exercise intervention in preschool children

We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine weiter...

Author: Specker B, Binkley T, Fahrenwald N
Source: Bone., 2004; 35(6): 1383-8, PMID: 15589220
GID: 1154; Last update: 29.02.2008

Research Studies (2005)

Peripheral quantitative computed tomography of the distal radius in young subjects - new reference data and interpretation of results

Application of bone densitometry to clinical use requires the availability of accessible reference data and is helped by an interpretative framework that is based on bone physiology. The aim of this contributio weiter...

Author: Rauch F, Schöenau E
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 119-26, PMID: 15951627
GID: 1162; Last update: 29.02.2008
More information: Original Article

Research Studies (2005)

Growth hormone changes bone geometry and body composition in patients with juvenile idiopathic arthritis requiring glucocorticoid treatment: a controlled study using peripheral quantitative computed tomography

Osteopenia and growth retardation have been described in children with chronic arthritis. GH has an impact on both. In the present controlled study, we used peripheral quantitative computed tomography to evalua weiter...

Author: Bechtold S, Ripperger P, Bonfig W, Pozza RD, Haefner R, Schwarz HP
Source: J Clin Endocrinol Metab., 2005; 90(6): 3168-73, PMID: 15769991
GID: 1158; Last update: 29.02.2008

Research Studies (2004)

Three children with lower limb fractures and a mineralization defect: a novel bone fragility disorder

In this report, we describe three unrelated children with an apparently novel bone fragility disorder that is associated with an idiopathic mineralization defect. Recurrent lower limb fractures started with wei weiter...

Author: Munns CF, Rauch F, Travers R, Glorieux FH
Source: Bone., 2004; 35(5): 1023-8, PMID: 15542026
GID: 1161; Last update: 29.02.2008

Research Studies (2004)

Estimation of bone mineral density and architectural parameters of the distal radius in hemodialysis patients using peripheral quantitative computed tomography

We analyzed bone changes in a series of hemodialysis patients followed up for a maximum of 299 months by assessing bone mineral density (BMD) and architectural parameters of the distal radius using peripheral q weiter...

Author: Hasegawa K, Hasegawa Y, Nagano A
Source: J Biomech., 2004; 37(5): 751-6, PMID: 15047004
GID: 1144; Last update: 28.02.2008

Research Studies (2004)

Estrogens are essential for male pubertal periosteal bone expansion

The skeletal response to estrogen therapy was studied in a 17-yr-old boy with congenital aromatase deficiency. As expected, estrogen therapy (1 mg estradiol valeriate/d from age 17 until 20 yr) normalized total weiter...

Author: Bouillon R, Bex M, Vanderschueren D, Boonen S
Source: J Clin Endocrinol Metab., 2004; 89(12): 6025-9, PMID: 15579754
GID: 1147; Last update: 28.02.2008

Research Studies (2004)

Lower estimates of net endogenous non-carbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women

BACKGROUND: The link between acid-base homeostasis and skeletal integrity has gained increasing prominence in the literature. Estimation of the net rate of endogenous non-carbonic acid production (NEAP) from di weiter...

Author: New SA, MacDonald HM, Campbell MK, Martin JC, Garton MJ, Robins SP, Reid DM
Source: Am J Clin Nutr., 2004; 79(1): 131-8, PMID: 14684409
GID: 1146; Last update: 28.02.2008

Research Studies (2001)

Bone mineral density in children with primary hyperoxaluria type I

BACKGROUND: In primary hyperoxaluria type I (PH 1), hepatic overproduction of oxalate leads to its deposition in various organ systems including bone (oxalosis). To evaluate skeletal status non-invasively in PH weiter...

Author: Behnke B, Kemper MJ, Kruse HP, Müller-Wiefel DE
Source: Nephrol Dial Transplant., 2001; 16(11): 2236-9, PMID: 11682674
GID: 1145; Last update: 28.02.2008

Research Studies (2004)

Total, trabecular, and cortical bone mineral density in different regions of the glenoid

The purpose of this study was to analyze total, trabecular, and cortical bone mineral density (BMD) of different regions of the glenoid. Soft tissue was dissected from 20 cadaveric shoulders, and the glenoids w weiter...

Author: Lehtinen JT, Tingart MJ, Apreleva M, Warner JJ
Source: J Shoulder Elbow Surg., 2004; 13(3): 344-8, PMID: 15111907
GID: 1143; Last update: 28.02.2008

Research Studies (2004)

Is muscle power output a key factor in the age-related decline in physical performance? A comparison of muscle cross section, chair-rising test and jumping power

Ageing compromises locomotor capacity and is associated with an increased risk of falls. Several lines of evidence indicate that both changes in muscle mass and performance are causative. Most studies, however, weiter...

Author: Runge M, Rittweger J, Russo CR, Schiessl H, Felsenberg D
Source: Clin Physiol Funct Imaging., 2004; 24(6): 335-40, PMID: 15522042
GID: 1148; Last update: 28.02.2008
More information: Original Article

Research Studies (2005)

The clinical significance of serum osteocalcin and N-terminal propeptide of type I collagen in predialysis patients with chronic renal failure

Several new serum markers for bone metabolism have recently become available and are being applied to clinical practice. Their clinical usefulness in predialysis patients with chronic renal failure (CRF), howev weiter...

Author: Tsuchida T, Ishimura E, Miki T, Matsumoto N, Naka H, Jono S, Inaba M, Nishizawa Y
Source: Osteoporos Int., 2005; 16(2): 172-9, PMID: 15164161
GID: 1149; Last update: 28.02.2008

Scientific Publications (2004)

The peak bone mass concept: is it still relevant

The peak bone mass concept implies that optimal skeletal development during childhood and adolescence will prevent fractures in late adulthood. This concept is based on the observation that areal bone density i weiter...

Author: Schönau E
Source: Pediatr Nephrol., 2004; 19(8): 825-31, PMID: 15197638
GID: 1138; Last update: 26.02.2008

Research Studies (2004)

Interpretation of whole body dual energy X-ray absorptiometry measures in children: comparison with peripheral quantitative computed tomography

The assessment of bone health in children requires strategies to minimize the confounding effects of bone size on dual energy X-ray absorptiometry (DXA) areal bone mineral density (BMD) results. Cortical bone c weiter...

Author: Leonard MB, Shults J, Elliott DM, Stallings VA, Zemel BS
Source: Bone., 2004; 34(6): 1044-52, PMID: 15193552
GID: 1134; Last update: 26.02.2008

Research Studies (2004)

Androgens and bone

Loss of estrogens or androgens increases the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal imbalance between resorption and format weiter...

Author: Vanderschueren D, Vandenput L, Boonen S, Lindberg MK, Bouillon R, Ohlsson C
Source: Endocr Rev., 2004; 25(3): 389-425, PMID: 15180950
GID: 1135; Last update: 26.02.2008

Research Studies (2002)

Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites

This study comprehensively analyzes the ability of site-specific and nonsite-specific clinical densitometric techniques for predicting mechanical strength of the distal radius in different loading configuration weiter...

Author: Lochmüller EM, Lill CA, Kuhn V, Schneider E, Eckstein F
Source: J Bone Miner Res., 2002; 17(9): 1629-38, PMID: 12211433
GID: 1133; Last update: 26.02.2008

Research Studies (2004)

Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)

The diagnosis of osteoporosis is generally based on the assessment of bone mineral content with dual X-ray absorptiometry (DXA) but does not account for the spatial distribution and inherent material properties weiter...

Author: Hudelmaier M, Kuhn V, Lochmüller EM, Well H, Priemel M, Link TM, Eckstein F
Source: Osteoporos Int., 2004; 15(5): 375-81, PMID: 14740151
GID: 1142; Last update: 26.02.2008

Research Studies (2004)

Accuracy and precision of peripheral quantitative computed tomography measurements at the tibial metaphysis

The ability of 29 peripheral quantitative computed tomography (pQCT) software analysis modes at defining cortical from trabecular bone at three tibial metaphyseal regions was evaluated using five cadaveric tibi weiter...

Author: Veitch SW, Findlay SC, Ingle BM, Ibbotson CJ, Barrington A, Hamer AJ, Eastell R
Source: J Clin Densitom., 2004; 7(2): 209-17, PMID: 15181265
GID: 1139; Last update: 26.02.2008

Research Studies (2004)

Analysis of the functional muscle-bone unit of the forearm in pediatric renal transplant recipients

BACKGROUND: Renal transplantation in children and adolescents is associated with various skeletal complications. The incidence of spontaneous fractures appears to be increased, but the reasons for this are not weiter...

Author: Rüth EM, Weber LT, Schoenau E, Wunsch R, Seibel MJ, Feneberg R, Mehls O, Tönshoff B
Source: Kidney Int., 2004; 66(4): 1694-706, PMID: 15458468
GID: 1140; Last update: 26.02.2008

Research Studies (2004)

Hemoglobin levels and skeletal muscle: results from the InCHIANTI study

BACKGROUND: Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative a weiter...

Author: Cesari M, Penninx BW, Lauretani F, Russo CR, Carter C, Bandinelli S, Atkinson H, Onder G, Pahor M, Ferrucci L
Source: J Gerontol A Biol Sci Med Sci., 2004; 59(3): 249-54, PMID: 15031309
GID: 1141; Last update: 26.02.2008

Research Studies (2003)

Predicting the failure load of the distal radius

The distal radius is an important site for the early detection of patients at risk for fracture. Since measuring bone strength in vivo is not possible, we evaluated which bone assessment method of the forearm w weiter...

Author: Muller ME, Webber CE, Bouxsein ML
Source: Osteoporos Int., 2003; 14(4): 345-52, PMID: 12730737
GID: 1119; Last update: 25.02.2008

Research Studies (2003)

The volumetric bone density and cortical thickness in adult patients affected by osteogenesis imperfecta

In patients with osteogenesis imperfecta (OI), a disease characterized by abnormal bone fragility, bone mineral density (BMD) was found to be relatively preserved. Quantitative computed tomography (QCT) is the weiter...

Author: Gatti D, Colapietro F, Fracassi E, Sartori E, Antoniazzi F, Braga V, Rossini M, Adami S
Source: J Clin Densitom., 2003; 6(2): 173-7, PMID: 12794240
GID: 1118; Last update: 25.02.2008

Research Studies (2003)

Cortical bone density is normal in prepubertal children with growth hormone (GH) deficiency, but initially decreases during GH replacement due to early bone remodeling

Dual energy x-ray absorptiometry (DEXA) has revealed that GH- deficient adults gain in bone mineral density during GH therapy. Measurements of volumetric bone density (grams per cubic centimeter vs. grams per s weiter...

Author: Schweizer R, Martin DD, Schwarze CP, Binder G, Georgiadou A, Ihle J, Ranke MB
Source: J Clin Endocrinol Metab., 2003; 88(11): 5266-72, PMID: 14602760
GID: 1117; Last update: 25.02.2008

Research Studies (2003)

Aging bone in men and women: beyond changes in bone mineral density

Using peripheral quantitative computed tomography (pQCT) we assessed trabecular and cortical bone density, mass and geometric distribution at the tibia level in 512 men and 693 women, age range 20-102 years, ra weiter...

Author: Russo CR, Lauretani F, Bandinelli S, Bartali B, Di Iorio A, Volpato S, Guralnik JM, Harris T, Ferrucci L
Source: Osteoporos Int., 2003; 14(7): 531-8, PMID: 12827220
GID: 1116; Last update: 25.02.2008

Research Studies (2002)

Volumetric and projective bone mineral density

Projectional bone mineral density measurement so far used extensively in radiogrammetry and single and dual source absorptiometry is confronted with a serious limitation for the accurate evaluation of true dens weiter...

Author: Fujita T
Source: J Musculoskelet Neuronal Interact., 2002; 2(4): 302-5, PMID: 15758420
GID: 1115; Last update: 25.02.2008
More information: Original Article

Research Studies (2004)

Augmentation experimentale de la resistance du radius distal osteoporotique par un ciment phosphocalcique

Le diagnostic et le traitement de l’ostéoporose sont focalisés sur la lutte contre la déminéralisation. Or, la densité minérale de l’os n’est pas directement corrélée à la résistance mécanique weiter...

Author: P Liverneaux
Source: Chirurgie de la main, 2004; 23: 37-44
GID: 1128; Last update: 25.02.2008

Research Studies (2003)

Effects of an excess and a deficiency of endogenous parathyroid hormone on volumetric bone mineral density and bone geometry determined by peripheral quantitative computed tomography in female subjects

Peripheral quantitative computed tomography (pQCT) is useful for evaluating volumetric bone mineral density (vBMD) as well as bone mineral density (BMD) of cortical and trabecular bones separately. Although PTH weiter...

Author: Chen Q, Kaji H, Iu MF, Nomura R, Sowa H, Yamauchi M, Tsukamoto T, Sugimoto T, Chihara K
Source: J Clin Endocrinol Metab., 2003; 88(10): 4655-8, PMID: 14557436
GID: 1122; Last update: 25.02.2008

Research Studies (2002)

Predicting human vertebral bone strength by vertebral static histomorphometry

The study investigates the relationship between static histomorphometry and bone strength of human lumbar vertebral bone. The ability of vertebral histomorphometry to predict vertebral bone strength was compare weiter...

Author: Thomsen JS, Ebbesen EN, Mosekilde L
Source: Bone., 2002; 30(3): 502-8, PMID: 11882465
GID: 1125; Last update: 25.02.2008

Research Studies (2004)

Relationship between the duration of paralysis and bone structure: a pQCT study of spinal cord injured individuals

The aim of the present study was to describe bone loss of the separate compartments of trabecular and cortical bone, as well as changes in bone geometry of a large number of spinal cord injured (SCI) individual weiter...

Author: Eser P, Frotzler A, Zehnder Y, Wick L, Knecht H, Denoth J, Schiessl H
Source: Bone., 2004; 34(5): 869-80, PMID: 15121019
GID: 1126; Last update: 25.02.2008

Research Studies (2003)

Hormone replacement therapy improves distal radius bone structure by endocortical mineral deposition

Hormone replacement therapy (HRT) produces a small increase in bone mineral density (BMD) when measured by dual energy X-ray absorptiometry (DXA). The corresponding decrease in fracture risk is more impressive, weiter...

Author: Muller ME, Webber CE, Adachi JD
Source: Can J Physiol Pharmacol., 2003; 81(10): 952-8, PMID: 14608412
GID: 1121; Last update: 25.02.2008

Research Studies (1999)

Age- and gender-related differences in vertebral bone mass, density, and strength

This study was designed to evaluate age- and gender-related differences in vertebral bone mass, density, and strength by dual-energy X-ray absorptiometry (DXA), quantitative computed tomography (QCT), periphera weiter...

Author: Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde L
Source: J Bone Miner Res., 1999; 14(8): 1394-403, PMID: 10457272
GID: 1124; Last update: 25.02.2008

Research Studies (2004)

Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometry

OBJECTIVE: Alterations of the skeletal system, including reduced bone mineral density, increased frequency of fractures, and changes in markers of bone metabolism, have been described in juvenile idiopathic art weiter...

Author: Roth J, Palm C, Scheunemann I, Ranke MB, Schweizer R, Dannecker GE
Source: Arthritis Rheum., 2004; 50(4): 1277-85, PMID: 15077312
GID: 1131; Last update: 25.02.2008
More information: Original Article

Research Studies (2008)

Peripheral quantitative computed tomography of the tibia: pediatric reference values.

Peripheral quantitative computed tomography (pQCT) has been used in a number of pediatric studies. Reference data for children are primarily limited to the radius. The purpose of this study was to establish nor weiter...

Author: Moyer-Mileur LJ, Quick JL, Murray MA
Source: J Clin Densitom, 2008; 11(2): 283-94, PMID: 18164637
Keywords: pädiatrie
GID: 1114; Last update: 23.02.2008

Research Studies (2001)

Bone quality parameters of the distal radius as assessed by pQCT in normal and fractured women

The aim of this study was to test the ability of some indicators of different aspects of bone quality (assessed by peripheral quantitative computed tomography in the distal radius) to discriminate between fract weiter...

Author: Schneider P, Reiners C, Cointry GR, Capozza RF, Ferretti JL
Source: Osteoporos Int., 2001; 12(8): 639-46, PMID: 11580077
GID: 1089; Last update: 07.02.2008

Research Studies (2001)

Age, sex, and grip strength determine architectural bone parameters assessed by peripheral quantitative computed tomography (pQCT) at the human radius

The purpose of this study was to estimate the relation of some noninvasively derived mechanical characteristics of radial bone including architectural parameters for bone strength to grip strength and muscle cr weiter...

Author: Hasegawa Y, Schneider P, Reiners C
Source: J Biomech., 2001; 34(4): 497-503, PMID: 11266673
GID: 1090; Last update: 07.02.2008

Research Studies (2002)

Die Muskel-Knochen-Einheit im Kindes- und Jugendalter. Konsequenzen für Prävention und Klassifikation der Osteoporose

Author: E Schönau
Source: Extracta Orthopaedica, 2002; 11: 20-25
GID: 1087; Last update: 07.02.2008

Research Studies (2003)

Mandible and maxilla bone mineral density and threshold analysis studies by pQCT in two edentulous women receiving pamidronate

The mandible and maxilla of two edentulous women, treated during 25 weeks with oral pamidronate, were monitored by peripheral quantitative tomography (pQCT). Whole bone volumetric mineral density failed to show weiter...

Author: Montangero VE, Capiglioni R, Roldán EJ
Source: Cranio., 2003; 21(2): 110-5, PMID: 12723856
GID: 1084; Last update: 07.02.2008

Research Studies (2003)

Bone mass and density response to a 12-month trial of calcium and vitamin D supplement in preadolescent girls

BACKGROUND: Maximal bone acquisition in adolescent girls through dietary and lifestyle practices is advocated to prevent or minimize the development of osteoporosis and its associated complications in later lif weiter...

Author: Moyer-Mileur LJ, Xie B, Ball SD, Pratt T
Source: J Musculoskelet Neuronal Interact., 2003; 3(1): 63-70, PMID: 15758367
GID: 1086; Last update: 07.02.2008
More information: Original Article

Research Studies (2003)

The value of peripheral quantitative computed tomography (pQCT) in the diagnosis of osteoporosis

AIM: To evaluate the accuracy of distal radial pQCT in discriminating between osteoporotic fracture and non fracture cases and its efficiency to predict fractures. METHODS: Densitometric data determined with an weiter...

Author: Niedhart C, Braun K, Graf Stenbock-Fermor N, Bours F, Schneider P, Zilkens KW, Niethard FU
Source: Z Orthop Ihre Grenzgeb., 2003; 141(2): 135-42, PMID: 12695948
GID: 1085; Last update: 07.02.2008

Research Studies (2003)

Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis

Treatment with teriparatide (rDNA origin) injection [teriparatide, recombinant human parathyroid hormone (1-34) [rhPTH(1-34)]] reduces the risk of vertebral and nonvertebral fragility fractures and increases ca weiter...

Author: Zanchetta JR, Bogado CE, Ferretti JL, Wang O, Wilson MG, Sato M, Gaich GA, Dalsky GP, Myers SL
Source: J Bone Miner Res., 2003; 18(3): 539-43, PMID: 12619939
GID: 1080; Last update: 07.02.2008

Research Studies (2003)

Analysis of the structure and strength of bones in celiac disease patients

OBJECTIVE: The aim of this study was to gain insight into the pathogenesis of bone mass loss and weakening affecting patients with celiac disease, according to the new concepts of bone structure/strength and mu weiter...

Author: Ferretti J, Mazure R, Tanoue P, Marino A, Cointry G, Vazquez H, Niveloni S, Pedreira S, Mauriño E, Zanchetta J, Bai JC
Source: Am J Gastroenterol., 2003; 98(2): 382-90, PMID: 12591059
GID: 1079; Last update: 07.02.2008

Research Studies (2002)

Alter-und geschlechtsabhängige Knochenmineraldichteverteilung und mechanische Eigenschaften des proximalen Humerus

Author: H Lill, P Hepp, W Gowin, JW Oestmann, J Korner, NP Haas, C Josten, GN Duda
Source: Fortschr. Röntgenstr., 2002; 174: 1544-1550
GID: 1078; Last update: 07.02.2008

Research Studies (2003)

Effect of alendronate and exercise on bone and physical performance of postmenopausal women: a randomized controlled trial

In this randomized, double-blind, placebo-controlled 12-month trial we evaluated effects of weight- bearing jumping exercise and oral alendronate, alone or in combination, on the mass and structure of bone, ris weiter...

Author: Uusi-Rasi K, Kannus P, Cheng S, Sievänen H, Pasanen M, Heinonen A, Nenonen A, Halleen J, Fuerst T, Genant H, Vuori I
Source: Bone., 2003; 33(1): 132-43, PMID: 12919708
GID: 1097; Last update: 07.02.2008

Research Studies (2002)

Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis

Despite an intriguing understanding of trabecular bone dynamics, little is known about corticosteroid-induced cortical bone loss and fractures. Recently, we verified a steroid-induced decrease in cortical bone weiter...

Author: Tsugeno H, Tsugeno H, Fujita T, Goto B, Sugishita T, Hosaki Y, Ashida K, Mitsunobu F, Tanizaki Y, Shiratori Y
Source: Osteoporos Int., 2002; 13(8): 650-6, PMID: 12181624
GID: 1096; Last update: 07.02.2008

Research Studies (2002)

Peripheral quantitative Computed Tomography (PQCT) in the evaluation of bone geometry, biomechanics and mineral density in postmenopausal women

AIM: Non-invasive assessment of bone geometry, biomechanics, and mineral content in postmenopausal women by peripheral quantitative Computed Tomography (pQCT). MATERIAL AND METHODS: Total, trabecular and cortic weiter...

Author: Di Leo C, Tarolo GL, Bagni B, Bestetti A, Tagliabue L, Pietrogrande L, Pepe L
Source: Radiol Med (Torino)., 2002; 103(3): 233-41, PMID: 11976620
GID: 1095; Last update: 07.02.2008

Research Studies (2002)

Measurement of bone adjacent to tibial shaft fracture

Delayed union and non-union are common complications after fracture of the tibial shaft. Response of the surrounding bone as a fracture heals could be monitored using techniques currently used in the study of o weiter...

Author: Findlay SC, Eastell R, Ingle BM
Source: Osteoporos Int., 2002; 13(12): 980-9, PMID: 12459941
GID: 1094; Last update: 07.02.2008

Research Studies (2002)

Patient-specific microarchitecture of vertebral cancellous bone: a peripheral quantitative computed tomographic and histological study

This study directly compares peripheral quantitative computed tomography (pQCT) and histology for the assessment of 11 morphological parameters. Sixty-eight cylindrical cancellous bone samples were cored from t weiter...

Author: Banse X, Devogelaer JP, Grynpas M
Source: Bone., 2002; 30(6): 829-35, PMID: 12052449
GID: 1077; Last update: 01.02.2008

Research Studies (2006)

Changes of trabecular bone density in elderly subjects: a 4-year prospective pQCT study

In large cohort studies changes in bone density and mass are often described statistically as mean values over a period of time1,2. This implies that bone loss occurs homogeneously in the study population over weiter...

Author: Schiessl H, Runge M, Willnecker J
Source: J Musculoskelet Neuronal Interact., 2006; 6(2): 160-1, PMID: 16849826
GID: 1070; Last update: 01.02.2008
More information: Original Article

Research Studies (2001)

Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine

OBJECTIVE: To examine bone development in children and adolescents who have uncomplicated idiopathic epilepsy and had received monotherapy with carbamazepine or valproic acid for at least 1 year. METHODS: Thirt weiter...

Author: Rieger-Wettengl G, Tutlewski B, Stabrey A, Rauch F, Herkenrath P, Schauseil-Zipf U, Schoenau E
Source: Pediatrics., 2001; 108(6): E107, PMID: 11731634
GID: 1075; Last update: 01.02.2008

Research Studies (2000)

Analysis of muscle strength and bone structure in children with renal disease

Bone structure and muscular strength of 30 children with renal disease were investigated by peripheral computed tomography and grip strength. Sixteen children suffered from nephrotic syndrome (NS) and had previ weiter...

Author: Tenbrock K, Kruppa S, Mokov E, Querfeld U, Michalk D, Schoenau E
Source: Pediatr Nephrol., 2000; 14(7): 669-72, PMID: 10912540
GID: 1076; Last update: 01.02.2008

Research Studies (2000)

High-impact exercise and bones of growing girls: a 9-month controlled trial

The maximum amount of bone a person can obtain during the first two decades of life is an important determinant of bone mass in later life, and an increase in peak bone mass has been associated with decreased r weiter...

Author: Heinonen A, Sievänen H, Kannus P, Oja P, Pasanen M, Vuori I
Source: Osteoporos Int., 2000; 11(12): 1010-7, PMID: 11256891
GID: 1047; Last update: 30.01.2008

Research Studies (2001)

Ultrasound velocity and cortical bone characteristics in vivo

Axial transmission of ultrasound along cortical bone may reflect a combination of material and structural properties of long bone cortices. The goal of this study was to determine the association of speed of so weiter...

Author: Sievänen H, Cheng S, Ollikainen S, Uusi-Rasi K
Source: Osteoporos Int., 2001; 12(5): 399-405, PMID: 11444089
GID: 1048; Last update: 30.01.2008

Research Studies (2001)

Postmenopausal changes in the distribution of the volumetric BMD of cortical bone. A pQCT study of the human leg

Three different regions of interest (ROIs) were defined in pQCT scans (XCT-3000 machine, Stratec, Germany) taken at the tibial mid-diaphyses of 12 pre-menopausal (pre-MP) and 12 post-menopausal (post-MP) women weiter...

Author: Roldán EJ, Capiglioni R, Cointry CR, Capozza RF, Ferretti JL
Source: J Musculoskelet Neuronal Interact., 2001; 2(2): 157-62, PMID: 15758464
GID: 1049; Last update: 30.01.2008
More information: Original Article

Research Studies (2001)

Changes in bone density during childhood and adolescence: an approach based on bone"s biological organization

Bone densitometry has great potential to improve our understanding of bone development. However, densitometric data in children rarely are interpreted in light of the biological processes they reflect. To stren weiter...

Author: Rauch F, Schoenau E
Source: J Bone Miner Res., 2001; 16(4): 597-604, PMID: 11315987
GID: 1066; Last update: 30.01.2008

Research Studies (2002)

Influence of puberty on muscle development at the forearm

Despite its fundamental importance for physical development, the growth of the muscle system has received relatively little consideration. In this study, we analyzed the relationship between cross-sectional are weiter...

Author: Neu CM, Rauch F, Rittweger J, Manz F, Schoenau E
Source: Am J Physiol Endocrinol Metab., 2002; 283(1): E103-7, PMID: 12067849
GID: 1060; Last update: 30.01.2008

Research Studies (2002)

The muscle-bone relationship: methods and management - perspectives in glycogen storage disease

Currently bone development is commonly presented as a process leading to the "accumulation of peak bone mass". Consequently, the usual approach to a suspected bone disorder in a child is to address the question weiter...

Author: Schönau E, Schwahn B, Rauch F
Source: Eur J Pediatr., 2002; 161 Suppl 1: S50-2, PMID: 12373571
GID: 1062; Last update: 30.01.2008

Research Studies (2001)

Modeling of cross-sectional bone size, mass and geometry at the proximal radius: a study of normal bone development using peripheral quantitative computed tomography

It is becoming increasingly accepted that bone size is an important determinant of bone mass. Studies on the development of bone size may therefore promote a better understanding of the basis of diseases which weiter...

Author: Neu CM, Rauch F, Manz F, Schoenau E
Source: Osteoporos Int., 2001; 12(7): 538-47, PMID: 11527050
GID: 1065; Last update: 30.01.2008

Research Studies (2002)

The bone behind a low areal bone mineral density: peripheral quantitative computed tomographic analysis in a woman with osteogenesis imperfecta

Areal bone mineral density (BMD) is the most widely used densitometric parameter. However, this approach makes it difficult to understand the structural basis of bone diseases, because a large number of bone pr weiter...

Author: Rauch F, Tutlewski B, Schönau E
Source: J Musculoskelet Neuronal Interact., 2002; 2(4): 306-8, PMID: 15758421
GID: 1061; Last update: 30.01.2008
More information: Original Article

Research Studies (2002)

Anthropometric assessment of muscularity during growth: estimating fat-free mass with 2 skinfold-thickness measurements is superior to measuring midupper arm muscle area in healthy prepubertal children

BACKGROUND: Anthropometric measurements are widely used to determine body composition, especially in children. OBJECTIVE: Our aim was to compare 2 of the simplest anthropometry-based equations available for det weiter...

Author: Boye KR, Dimitriou T, Manz F, Schoenau E, Neu C, Wudy S, Remer T
Source: Am J Clin Nutr., 2002; 76(3): 628-32, PMID: 12198010
GID: 1063; Last update: 30.01.2008

Research Studies (2001)

Cut-off values determined for vertebral fracture by peripheral quantitative computed tomography in Japanese women

In spite of the benefits of bone mass measurement by dual-energy X-ray absorptiometry (DXA), the use of DXA has limitations. It is unable to assess a true bone density, and cannot discriminate between the trabe weiter...

Author: Gorai I, Nonaka K, Kishimoto H, Sakata H, Fujii Y, Fujita T
Source: Osteoporos Int., 2001; 12(9): 741-8, PMID: 11605740
GID: 1059; Last update: 30.01.2008

Research Studies (2002)

Site-specific skeletal response to long-term weight training seems to be attributable to principal loading modality: a pQCT study of female weightlifters

Physical training may be able to improve bone strength through site-specific changes in the composition, size and structure of the bone without notable increases in volumetric density. To address this possibili weiter...

Author: Heinonen A, Sievänen H, Kannus P, Oja P, Vuori I
Source: Calcif Tissue Int., 2002; 70(6): 469-74, PMID: 12016461
GID: 1058; Last update: 30.01.2008

Research Studies (2001)

Musculoskeletal analyses of the forearm in young women with Turner syndrome: a study using peripheral quantitative computed tomography

Turner syndrome (TS) is associated with multiple skeletal abnormalities. Fracture incidence appears to be increased, but the reasons for this are not entirely clear. In the present study, we used peripheral qua weiter...

Author: Bechtold S, Rauch F, Noelle V, Donhauser S, Neu CM, Schoenau E, Schwarz HP
Source: J Clin Endocrinol Metab., 2001; 86(12): 5819-23, PMID: 11739445
GID: 1057; Last update: 30.01.2008

Research Studies (2002)

Gender-specific pubertal changes in volumetric cortical bone mineral density at the proximal radius

It is well established that puberty affects the geometry of cortical bone differently in females and males. In the present study we investigated whether there are also gender differences in the volumetric bone weiter...

Author: Schoenau E, Neu CM, Rauch F, Manz F
Source: Bone., 2002; 31(1): 110-3, PMID: 12110422
GID: 1055; Last update: 30.01.2008

Research Studies (2001)

Prediction of strength of cortical bone in vitro by microcomputed tomography

OBJECTIVE: The aim of this study was to evaluate the predictive value of bone mineral density and intracortical porosity measured by microcomputed tomography for the strength of cortical bone biopsies. DESIGN: weiter...

Author: Wachter NJ, Augat P, Krischak GD, Sarkar MR, Mentzel M, Kinzl L, Claes L
Source: Clin Biomech (Bristol, Avon)., 2001; 16(3): 252-6, PMID: 11240061
GID: 1052; Last update: 30.01.2008

Research Studies (2001)

Peripheral quantitative computed tomography at the distal radius: cross-calibration between two scanners

Peripheral quantitative computed tomography (pQCT) is an important technique to study the interaction between the muscle and bone systems. We have recently established pQCT reference ranges for children, adoles weiter...

Author: Rauch F, Tutlewski B, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2001; 2(2): 153-5, PMID: 15758463
GID: 1050; Last update: 30.01.2008
More information: Original Article

Research Studies (2002)

Bone mineral content per muscle cross-sectional area as an index of the functional muscle-bone unit

Bone densitometric data often are difficult to interpret in children and adolescents because of large inter- and intraindividual variations in bone size. Here, we propose a functional approach to bone densitome weiter...

Author: Schoenau E, Neu CM, Beck B, Manz F, Rauch F
Source: J Bone Miner Res., 2002; 17(6): 1095-101, PMID: 12054165
GID: 1053; Last update: 30.01.2008

Research Studies (2001)

Predictive value of Singh index and bone mineral density measured by quantitative computed tomography in determining the local cancellous bone quality of the proximal femur

OBJECTIVE: The purpose of this study was to assess the predictive value of the Singh index as well as quantitative computed tomography for the in vitro local mechanical competence of the cancellous bone of the weiter...

Author: Wachter NJ, Augat P, Hoellen IP, Krischak GD, Sarkar MR, Mentzel M, Kinzl L, Claes L
Source: Clin Biomech (Bristol, Avon)., 2001; 16(3): 257-62, PMID: 11240062
GID: 1051; Last update: 30.01.2008

Research Studies (2000)

Biomechanical Examinations for Validation of the Bone Strength Strain Index SSI, Calculated by Peripheral Quantitative Computed Tomography

Author: G Wilhelm, D Felsenberg, G Bogusch, J Willnecker, J Thaten, P Gummert
Source: MusculoSkeletal Interactions, 2000; 2: 47-52
GID: 1029; Last update: 29.01.2008

Research Studies (2000)

Peripheral computed tomography (pQCT) detected short-term effect of AAACa (heated oyster shell with heated algal ingredient HAI): a double-blind comparison with CaCO3 and placebo

Trabecular bone density at the distal radius and cortical bone density at the midradius were measured in four randomized groups of women before and after 4 months administration of AAACa, oyster shell heated un weiter...

Author: Fujita T, Fujii Y, Goto B, Miyauchi A, Takagi Y
Source: J Bone Miner Metab., 2000; 18(4): 212-5, PMID: 10874600
GID: 1041; Last update: 29.01.2008

Research Studies (2001)

Bone densities and bone size at the distal radius in healthy children and adolescents: a study using peripheral quantitative computed tomography

Peripheral quantitative computed tomography (pQCT) has the ability to improve the diagnostic utility of densitometry in children and adolescents, because bone size and volumetric bone mineral density (vBMD) can weiter...

Author: Neu CM, Manz F, Rauch F, Merkel A, Schoenau E
Source: Bone., 2001; 28(2): 227-32, PMID: 11182383
GID: 1037; Last update: 29.01.2008

Research Studies (1998)

The development of the skeletal system in children and the influence of muscular strength

In a study on 14 healthy children aged from 6 to 13 years, the volumetric spongiosa bone density (SBD), cortical bone density (CBD), bone cross-sectional area (BCSA), cortical area (CA), and bone strength index weiter...

Author: Schönau E
Source: Horm Res., 1998; 49(1): 27-31, PMID: 9438782
GID: 1007; Last update: 29.01.2008

Research Studies (2001)

The development of bone strength at the proximal radius during childhood and adolescence

Current investigations of bone development mostly focus on bone mass, but bone strength may be functionally more important than mass. Therefore, we compared the developmental changes in cortical bone mass (BMCc weiter...

Author: Schoenau E, Neu CM, Rauch F, Manz F
Source: J Clin Endocrinol Metab., 2001; 86(2): 613-8, PMID: 11158018
GID: 1036; Last update: 29.01.2008

Research Studies (2000)

Association of the vitamin D receptor genotype BB with low bone density in hyperthyroidism

Bone mineral density (BMD) is modulated by genetic and environmental factors or certain diseases. In several conditions such as low calcium intake, an influence of vitamin D receptor (VDR) polymorphisms on BMD weiter...

Author: Obermayer-Pietsch BM, Frühauf GE, Chararas K, Mikhail-Reinisch S, Renner W, Berghold A, Kenner L, Lackner C
Source: J Bone Miner Res., 2000; 15(10): 1950-5, PMID: 11028447
GID: 1039; Last update: 29.01.2008

Research Studies (2001)

Bone density in asthmatic children treated with inhaled corticosteroids

Volumetric trabecular bone mineral density of the lumbar spine (vTBMD) and distal radius (rTBMD) were measured in 20 prepubertal white asthmatic children treated with moderate to high doses of inhaled corticost weiter...

Author: Reilly SM, Hambleton G, Adams JE, Mughal MZ
Source: Arch Dis Child., 2001; 84(2): 183-4, PMID: 11159303
GID: 1034; Last update: 29.01.2008

Research Studies (1998)

On new opportunities for absorptiometry

Mechanical loads cause bone strains; and muscle forces, not body weight, cause the largest strains. The strains help to control the effects of bone modeling and remodeling on bone strength and "mass." When stra weiter...

Author: Ferretti JL, Schiessl H, Frost HM
Source: J Clin Densitom., 1998; 1(1): 41-53, PMID: 15304912
GID: 1024; Last update: 29.01.2008

Research Studies (1996)

Influence of muscle strength on bone strength during childhood and adolescence

In connection with the prevention of osteoporosis, paediatrics is challenged with ensuring the optimal formation of the skeletal system with maximal bone strength during childhood and youth. Biomechanical use r weiter...

Author: Schönau E, Werhahn E, Schiedermaier U, Mokow E, Schiessl H, Scheidhauer K, Michalk D
Source: Horm Res., 1996; 45 Suppl 1: 63-6, PMID: 8805035
GID: 1009; Last update: 29.01.2008

Research Studies (1999)

Tomographical description of tennis-loaded radius: reciprocal relation between bone size and volumetric BMD

Effects of long-term tennis loading on volumetric bone mineral density (vBMD) and geometric properties of playing-arm radius were examined. Paired forearms of 16 tennis players (10 women) and 12 healthy control weiter...

Author: Ashizawa N, Nonaka K, Michikami S, Mizuki T, Amagai H, Tokuyama K, Suzuki M
Source: J Appl Physiol., 1999; 86(4): 1347-51, PMID: 10194221
GID: 1015; Last update: 29.01.2008

Research Studies (2000)

Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players

Bilateral bone characteristics of the humerus (proximal, shaft, and distal sites) and radius (shaft and distal sites) in 12 former Finnish national-level male tennis players (mean age 30 years) and their 12 age weiter...

Author: Haapasalo H, Kontulainen S, Sievänen H, Kannus P, Järvinen M, Vuori I
Source: Bone., 2000; 27(3): 351-7, PMID: 10962345
GID: 1028; Last update: 29.01.2008

Research Studies (1999)

Age-related changes in the biochemical properties of human cancellous bone collagen: relationship to bone strength

The metabolism of bone collagen has received little attention in relation to age-related loss of bone mass and strength. The aim of the present study was to analyze bone collagen content and metabolism in human weiter...

Author: Bailey AJ, Sims TJ, Ebbesen EN, Mansell JP, Thomsen JS, Mosekilde L
Source: Calcif Tissue Int., 1999; 65(3): 203-10, PMID: 10441651
GID: 1017; Last update: 29.01.2008

Research Studies (1998)

Peripheral quantitative computed tomography in human long bones: evaluation of in vitro and in vivo precision

Despite the excellent performance in clinical practice and research, the dual-energy X-ray absorptiometry is restricted by the inherent planar nature of the measurement and the inability to discriminate between weiter...

Author: Sievänen H, Koskue V, Rauhio A, Kannus P, Heinonen A, Vuori I
Source: J Bone Miner Res., 1998; 13(5): 871-82, PMID: 9610752
GID: 1005; Last update: 29.01.2008

Research Studies (1999)

Alendronate increases bone density and bone strength at the distal radius in postmenopausal women

In addition to the alendronate Osteoporosis Intervention Trial (FOSIT) core protocol 901-0A of 1908 enrolled patients, the use of peripheral quantitative computed tomography (pQCT) was explored for the assessme weiter...

Author: Schneider PF, Fischer M, Allolio B, Felsenberg D, Schröder U, Semler J, Ittner JR
Source: J Bone Miner Res., 1999; 14(8): 1387-93, PMID: 10457271
GID: 1010; Last update: 29.01.2008

Research Studies (1999)

Bone metabolism and bone mineral density in childhood hypophosphatasia

Childhood hypophosphatasia (HP) is an inborn error of bone metabolism, characterized by a reduced tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). Bone mineral density (BMD) in childhood HP has no weiter...

Author: Girschick HJ, Schneider P, Kruse K, Huppertz HI
Source: Bone., 1999; 25(3): 361-7, PMID: 10495141
GID: 1016; Last update: 29.01.2008

Research Studies (1999)

Long-term recreational gymnastics, estrogen use, and selected risk factors for osteoporotic fractures

The purpose of this cross-sectional study was to examine whether long-term participation in recreational gymnastics or folk dancing or estrogen replacement therapy (ERT) is associated with mechanically more com weiter...

Author: Uusi-Rasi K, Sievänen H, Vuori I, Heinonen A, Kannus P, Pasanen M, Rinne M, Oja P
Source: J Bone Miner Res., 1999; 14(7): 1231-8, PMID: 10404026
GID: 1011; Last update: 29.01.2008

Research Studies (1998)

Comparison of total and regional body composition in adolescent patients with anorexia nervosa and pair-matched controls

Body composition in 31 adolescent girls suffering from anorexia nervosa (AN) was measured at the time of hospitalization in order to assess the muscle/bone relationship as a potential source of the development weiter...

Author: Schneider P, Biko J, Schlamp D, Trott GE, Badura F, Warnke A, Reiners C
Source: Eat Weight Disord., 1998; 3(4): 179-87, PMID: 10728169
GID: 1012; Last update: 29.01.2008

Research Studies (1999)

Lumbar vertebral body compressive strength evaluated by dual-energy X-ray absorptiometry, quantitative computed tomography, and ashing

Bone densitometry with DXA (dual energy X-ray absorptiometry) and QCT (quantitative computed tomography) techniques are used for in vivo assessment of bone strength and thereby prediction of fracture risk. Howe weiter...

Author: Ebbesen EN, Thomsen JS, Beck-Nielsen H, Nepper-Rasmussen HJ, Mosekilde L
Source: Bone., 1999; 25(6): 713-24, PMID: 10593417
GID: 1020; Last update: 29.01.2008

Research Studies (1999)

Age at menarche and cortical bone geometry in premenopausal women

Previous studies have suggested that the timing of puberty might have an impact on the adult skeleton. What composite of bone structure could be affected by the timing of puberty is unknown at present. In this weiter...

Author: Rauch F, Klein K, Allolio B, Schönau E
Source: Bone., 1999; 25(1): 69-73, PMID: 10423024
GID: 1013; Last update: 29.01.2008

Research Studies (1998)

Trabecular bone mineral and calculated structure of human bone specimens scanned by peripheral quantitative computed tomography: relation to biomechanical properties

The relationship of cortical bone mineral density (BMD), and geometry to bone strength has been well documented. In this study, we used peripheral quantitative computerized tomography (pQCT) to acquire trabecul weiter...

Author: Jiang Y, Zhao J, Augat P, Ouyang X, Lu Y, Majumdar S, Genant HK
Source: J Bone Miner Res., 1998; 13(11): 1783-90, PMID: 9797489
GID: 1014; Last update: 29.01.2008

Research Studies (1999)

Peripheral quantitative computed tomography of the femoral neck in 60 Japanese women

Peripheral quantitative computed tomography (pQCT) is able to evaluate trabecular and cortical bone separately, and to determine geometric properties from cross-sectional images for noninvasive assessments of m weiter...

Author: Horikoshi T, Endo N, Uchiyama T, Tanizawa T, Takahashi HE
Source: Calcif Tissue Int., 1999; 65(6): 447-53, PMID: 10594163
GID: 1019; Last update: 29.01.2008

Research Studies (2000)

Age-related changes assessed by peripheral QCT in healthy Italian women

The purpose of this study was to describe the normal cross-sectional pattern of radial bone loss associated with aging in healthy women and to generate a normative database using peripheral quantitative compute weiter...

Author: Guglielmi G, De Serio A, Fusilli S, Scillitani A, Chiodini I, Torlontano M, Cammisa M
Source: Eur Radiol., 2000; 10(4): 609-14, PMID: 10795543
GID: 1018; Last update: 29.01.2008

Research Studies (1999)

Precision and intersite correlation of bone densitometry at the radius, tibia and femur with peripheral quantitative CT

OBJECTIVE: To compare the in situ precision of peripheral quantitative CT (pQCT) at the radius, tibia and femur, and to analyze the intersite correlation, in order to determine whether measurements at the lower weiter...

Author: Groll O, Lochmüller EM, Bachmeier M, Willnecker J, Eckstein F
Source: Skeletal Radiol., 1999; 28(12): 696-702, PMID: 10653365
GID: 1021; Last update: 29.01.2008

Research Studies (1999)

Measurement of forearm bone in children by peripheral computed tomography

By means of peripheral computed tomography (pQCT), adult cortical bone density and volume was shown to be under a fixed rectilinear relationship regardless of age, sex, and presence or absence of osteoporosis. weiter...

Author: Fujita T, Fujii Y, Goto B
Source: Calcif Tissue Int., 1999; 64(1): 34-9, PMID: 9868281
GID: 1003; Last update: 29.01.2008

Research Studies (1998)

Clinical evaluation of a high-resolution new peripheral quantitative computerized tomography (pQCT) scanner for the bone densitometry at the lower limbs

Precision, long-term stability, linearity and accuracy of the x-ray peripheral quantitative computerized tomographic (pQCT) bone scanner XCT 3000 (Norland-Stratec Medical Sys.) were evaluated using the European weiter...

Author: Braun MJ, Meta MD, Schneider P, Reiners C
Source: Phys Med Biol., 1998; 43(8): 2279-94, PMID: 9725604
GID: 1006; Last update: 29.01.2008

Research Studies (1999)

Bone density reduction in various measurement sites in men and women with osteoporotic fractures of spine and hip: the European quantitation of osteoporosis study

We have measured bone mineral density (BMD) using dual X-ray absorptiometry (DXA) of the spine and hip, spinal quantitative computed tomography (QCTspi), and peripheral radial quantitative computed tomography ( weiter...

Author: Kröger H, Lunt M, Reeve J, Dequeker J, Adams JE, Birkenhager JC, Diaz Curiel M, Felsenberg D, Hyldstrup L, Kotzki P, Laval-Jeantet A, Lips P, Louis O, Perez Cano R, Reiners C, Ribot C, Ruegsegger P, Schneider P, Braillon P, Pearson J
Source: Calcif Tissue Int., 1999; 64(3): 191-9, PMID: 10024374
GID: 1004; Last update: 29.01.2008

Research Studies (1998)

Diagnostic sensitivity of peripheral quantitative computed tomography measurements at ultradistal and proximal radius in postmenopausal women

Peripheral quantitative computed tomography (pQCT) is a bone densitometry technique that is able to provide real volumetric bone density values not only of the total but also of trabecular and cortical bone sep weiter...

Author: Nijs J, Westhovens R, Joly J, Cheng XG, Borghs H, Dequeker J
Source: Bone., 1998; 22(6): 659-64, PMID: 9626405
GID: 1002; Last update: 29.01.2008

Research Studies (2000)

pQCT measurement of bone parameters in young children: validation of technique

Dual-energy X-ray absorptiometry (DXA) measures areal bone mineral density (BMD) and is affected by bone size. Peripheral quantitative computed tomography (pQCT) measures volumetric density and should not be af weiter...

Author: Binkley TL, Specker BL
Source: J Clin Densitom., 2000; 3(1): 9-14, PMID: 10745298
GID: 1042; Last update: 29.01.2008

Research Studies (2001)

The development of metaphyseal cortex--implications for distal radius fractures during growth

Fractures of the distal radial metaphysis are very common in otherwise healthy children. The reasons for this high fracture incidence are not entirely clear. To address this problem, we undertook a detailed ana weiter...

Author: Rauch F, Neu C, Manz F, Schoenau E
Source: J Bone Miner Res., 2001; 16(8): 1547-55, PMID: 11499878
GID: 1044; Last update: 29.01.2008

Research Studies (2000)

Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health

BACKGROUND: The role of nutritional influences on bone health remains largely undefined because most studies have focused attention on calcium intake. OBJECTIVE: We reported previously that intakes of nutrients weiter...

Author: New SA, Robins SP, Campbell MK, Martin JC, Garton MJ, Bolton-Smith C, Grubb DA, Lee SJ, Reid DM
Source: Am J Clin Nutr., 2000; 71(1): 142-51, PMID: 10617959
GID: 1040; Last update: 29.01.2008

Research Studies (2001)

Inhomogeneity of human vertebral cancellous bone: systematic density and structure patterns inside the vertebral body

In the spine, cancellous bone quality is usually assessed for the whole vertebral body in a transverse central slice. Correct identification and assessment of the weakest parts of the cancellous bone may lead t weiter...

Author: Banse X, Devogelaer JP, Munting E, Delloye C, Cornu O, Grynpas M
Source: Bone., 2001; 28(5): 563-71, PMID: 11344057
GID: 1043; Last update: 29.01.2008

Research Studies (2000)

Estimation of the architectural properties of cortical bone using peripheral quantitative computed tomography

We assessed the volumetric bone mineral density (vBMD) and cross-sectional architecture of cortical bone at the distal radius by peripheral quantitative computed tomography (pQCT). The volumetric bone mineral d weiter...

Author: Hasegawa Y, Schneider P, Reiners C, Kushida K, Yamazaki K, Hasegawa K, Nagano A
Source: Osteoporos Int., 2000; 11(1): 36-42, PMID: 10663357
GID: 1045; Last update: 29.01.2008

Research Studies (2001)

Comparison of bone parameters by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography in Hutterite vs. non-Hutterite women aged 35-60 years

A previous report of elevated dual-energy X-ray absorptiometry (DXA) bone mineral density (BMD) Z scores suggests that Hutterite females might be significantly less likely to develop osteoporosis compared with weiter...

Author: Wosje KS, Binkley TL, Specker BL
Source: Bone., 2001; 29(2): 192-7, PMID: 11502483
GID: 1046; Last update: 29.01.2008

Research Studies (1997)

Noninvasive Assessment of Bone Architecture and Biomechanical Properties in Animals and Humans Employing pQCT Technology

Author: J L Ferretti
Source: J Jpn Soc Bone Morphom, 1997; 7: 115-125
GID: 999; Last update: 29.01.2008

Research Studies (2000)

Musculoskeletal Interactions in Normal Subjects and Dialysis Patients

Author: CR Russo
Source: MusculoSkeletal Interactions, 2000; 2: 105 - 110
GID: 1030; Last update: 29.01.2008
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Research Studies (2000)

Densitometric and tomographic analyses of musculoskeletal interactions in humans

Previous studies with standard densitometry (DXA) have suggested that the bone mass is strongly dependent on the muscle mass in the species, following a similar relationship at any age and sex hormones or relat weiter...

Author: Ferretti JL, Capozza RF, Cointry GR, Capiglioni R, Roldan EJ, Zanchetta JR
Source: J Musculoskelet Neuronal Interact., 2000; 1(1): 31-4, PMID: 15758522
GID: 1031; Last update: 29.01.2008
More information: Original Article

Research Studies (2000)

Contributions of bone density and geometry to the strength of the human second metatarsal

We investigated, at the whole bone level, the contribution of bone density and geometry to the fracture load of the second metatarsal, a bone that is prone to stress fracture. Dual-energy X-ray absorptiometry ( weiter...

Author: Muehleman C, Lidtke R, Berzins A, Becker JH, Shott S, Sumner DR
Source: Bone., 2000; 27(5): 709-14, PMID: 11062360
GID: 1032; Last update: 29.01.2008

Research Studies (2000)

Ultrasonographic, axial, and peripheral measurements in female patients with benign hypermobility syndrome

Twenty-five female Caucasians, aged 19-57 years, with the hypermobility syndrome had bone density measurements using established noninvasive techniques such as dual X-ray absorptiometry (DXA), single photon abs weiter...

Author: Nijs J, Van Essche E, De Munck M, Dequeker J
Source: Calcif Tissue Int., 2000; 67(1): 37-40, PMID: 10908410
GID: 1025; Last update: 29.01.2008

Research Studies (2000)

Bone-muscle strength indices for the human lower leg

This cross-sectional study is based on images from the lower leg as assessed by peripheral quantitative computer tomography (pQCT). Measurements were performed in 39 female and 38 male control subjects and 15 f weiter...

Author: Rittweger J, Beller G, Ehrig J, Jung C, Koch U, Ramolla J, Schmidt F, Newitt D, Majumdar S, Schiessl H, Felsenberg D
Source: Bone., 2000; 27(2): 319-26, PMID: 10913929
GID: 1035; Last update: 29.01.2008

Research Studies (2001)

Predictive value of bone mineral density and morphology determined by peripheral quantitative computed tomography for cancellous bone strength of the proximal femur

Peripheral quantitative computed tomography (pQCT) is an established diagnostic method for assessment of bone mineral density in the diagnosis of osteoporosis. However, the capacity of structural parameters of weiter...

Author: Wachter NJ, Augat P, Mentzel M, Sarkar MR, Krischak GD, Kinzl L, Claes LE
Source: Bone., 2001; 28(1): 133-9, PMID: 11165955
GID: 1033; Last update: 29.01.2008

Research Studies (1997)

Volumetric bone mineral density using peripheral quantitative computed tomography in Japanese women

The present study evaluated a commercial device for peripheral quantitative computed tomography (pQCT) and examined the age-related changes in normal Japanese women. The volumetric bone mineral density (vBMD) o weiter...

Author: Hasegawa Y, Kushida K, Yamazaki K, Inoue T
Source: Osteoporos Int., 1997; 7(3): 195-9, PMID: 9205630
GID: 991; Last update: 24.01.2008

Research Studies (1996)

Comparison of trabecular bone density at vertebral and radial sites using quantitative computed tomography

Trabecular volumetric bone mineral density (VMD) was measured at the lumbar spine using quantitative computed tomography (QCT) and at the distal radius using peripheral QCT (pQCT) in 60 Japanese women aged 21-8 weiter...

Author: Fujii Y, Chikawa T, Nakamura T, Goto B, Fujita T
Source: Osteoporos Int., 1996; 6(6): 486-90, PMID: 9116395
GID: 988; Last update: 24.01.2008

Research Studies (1996)

Measurement of radial bone mineral density and cortical thickness in children by peripheral quantitative computed tomography

Author: De Schepper, De Boeck & O. Louis
Source: Paediatric osteology, 1996; 135-140
GID: 986; Last update: 24.01.2008

Research Studies (1996)

Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell

Quantitative bone assessment today is primarily based on the analysis of bone mineral density (BMD). The geometric properties of bone, which are an important parameter for skeletal strength, are generally not c weiter...

Author: Augat P, Reeb H, Claes LE
Source: J Bone Miner Res., 1996; 11(9): 1356-63, PMID: 8864911
GID: 984; Last update: 24.01.2008

Research Studies (1996)

Bone and muscle development during childhood in health and disease

Author: E. Schönau, E. Werhahn, U. Schiedermaier, E. Mokov, K. Scheidhauer, E. Rietschel, F. Haverkamp, H. Schießl & D. Michalk
Source: Paediatric osteology, 1996; 1996
GID: 987; Last update: 24.01.2008

Research Studies (1995)

Knochenmineralgehalt bei Kindern und Jugendlichen mit Hyperkalziurie

Author: B. Lettgen, P. Rasche Ch. Reiners
Source: Monatssch. Kinderheilkunde, 1995; 143: 46-49
GID: 973; Last update: 24.01.2008

Research Studies (1995)

Bone mineral density in children and adolescents with juvenile diabetes: selective measurement of bone mineral density of trabecular and cortical bone using peripheral quantitative computed tomography

Bone mineral density (BMD) was studied in 21 children and adolescents with type I diabetes and in age- and sex-matched healthy controls. BMD was selectively measured in trabecular and total bone using periphera weiter...

Author: Lettgen B, Hauffa B, Möhlmann C, Jeken C, Reiners C
Source: Horm Res., 1995; 43(5): 173-5, PMID: 7782045
GID: 977; Last update: 24.01.2008

Research Studies (1994)

Influence of steroid medication on bone mineral density in children with nephrotic syndrome

Bone mineral density (BMD) was studied in 26 children with idiopathic nephrotic syndrome and in age- and sex-matched healthy controls. BMD was selectively measured in trabecular (TBD), cortical (CBD) and total weiter...

Author: Lettgen B, Jeken C, Reiners C
Source: Pediatr Nephrol., 1994; 8(6): 667-70, PMID: 7696102
GID: 976; Last update: 24.01.2008

Research Studies (1996)

Knochendichte bei Kindern und Jugendlichen mit rheumatischen Erkrankungen. Vorläufige Ergebnisse einer Selektiven Messung von Spongiosa und Kortikalis mittels peripherer Computertomographie

(english) Selective measurements of bone mineral density (BMD) of trabecular and cortical bone at the ultradistal radius were made in 27 children with rheumatic diseases and in age- and sex-matched healthy con weiter...

Author: Lettgen B, Neudorf U, Hosse R, Peters S, Reiners C
Source: Klin Pädiatr, 1996; 208: 117-117
GID: 981; Last update: 24.01.2008

Research Studies (1995)

Multicenter German reference data base for peripheral quantitative computer tomography

The wide spread use of bone densitometers in Germany and other European countries has required the establishment of a validated reference population data base. A semianthropomorphic forearm cross-calibration ph weiter...

Author: Schneider P, Butz S, Allolio B, Börner W, Klein K, Lehmann R, Petermann K, Tysarczyk-Niemeyer G, Wüster C, Zander C, , et al
Source: Technol Health Care., 1995; 3(2): 69-73, PMID: 8574764
GID: 979; Last update: 24.01.2008

Research Studies (1996)

Noninvasive bone strength index as analysed by peripheral quantitative computed tomography

Author: H. Schießl, J.L.Ferretti, G. Tysarczyk-Niemeyer & J. Willnecker
Source: Paediatric Osteology, 1996; 141-145
GID: 982; Last update: 24.01.2008

Research Studies (1995)

Cortical mineral content of the radius assessed by peripheral QCT predicts compressive strength on biomechanical testing

Our aim was to evaluate the role of cortical bone in resistance to compression in the human radius. Thirty-three left cadaver forearms were scanned on an XCT 960 Stratec CT scanner. Cortical density and cortica weiter...

Author: Louis O, Boulpaep F, Willnecker J, Van den Winkel P, Osteaux M
Source: Bone., 1995; 16(3): 375-9, PMID: 7786641
GID: 978; Last update: 24.01.2008

Research Studies (1996)

Cortical and total bone mineral content of the radius: accuracy of peripheral computed tomography

The aim of the study was to evaluate the accuracy of an XCT 960 Stratec peripheral quantitative computed tomography (pQCT) device in assessing bone mineral content of the radius. We scanned 27 left forearm spec weiter...

Author: Louis O, Soykens S, Willnecker J, Van den Winkel P, Osteaux M
Source: Bone., 1996; 18(5): 467-72, PMID: 8739905
GID: 983; Last update: 24.01.2008

Research Studies (1995)

Cortical thickness assessed by peripheral quantitative computed tomography: accuracy evaluated on radius specimens

The purpose of the present study was to evaluate the accuracy of peripheral quantitative computed tomography (pQCT) in measuring the thickness of the radial cortex. Thirty left forearm specimens were scanned on weiter...

Author: Louis O, Willnecker J, Soykens S, Van den Winkel P, Osteaux M
Source: Osteoporos Int., 1995; 5(6): 446-9, PMID: 8695966
GID: 980; Last update: 24.01.2008

Research Studies (1997)

Quantitative computed tomography at the axial and peripheral skeleto

Author: Guglielmi G, Schneider P, Lang TF, Giannatempo GM, Cammisa M, Genant HK
Source: Eur Radiol., 1997; 7(10): 32-42, PMID: 9042764
GID: 989; Last update: 24.01.2008

Research Studies (2003)

Änderung der Kraft und Stellenwert verschiedener Kraftmessmethoden bei älteren Frauen

Problemstellung: Der Verlust an Muskelkraft und -leistung ist bedeutsamer Risikofaktor für das erhöhte Sturz und Frakturrisiko im Alter. Die Erfassung der Muskelkraft/-leistung und des Muskelstatus spielt d weiter...

Author: Lammel C, Siegrist M, Zelger O, Jeschke D
Source: D. Zeitschrift Sportmed., Po-059, 2003; 54(7/8): 67
Keywords: elderly force
GID: 577; Last update: 02.01.2008

Research Studies (2006)

Zur Bedeutung der Körperhaltung beim Training auf Vibrationsplattformen

Das Training auf Vibrationsplattformen gilt als eine neue effiziente Trainingsform, die sowohl im Sport als auch in der Rehabilitation verwendet wird. In eigenen Studien wurde nachgewiesen, dass die Körperhalt weiter...

Author: Berschin G, Fischer H, Sommer HM
Source: Z. f. Physiotherapeuten, 2006; 58/3: 208-212
Keywords: Körperhaltung auf Galileo
GID: 407; Last update: 05.12.2007

Research Studies (2000)

Correlation of Strength Strain Index (SSI) and Torque in Upper Limbs

Author: Hartard M, Horn D, Bartenstein P, Schießl H
Source: 2000;
GID: 358; Last update: 04.12.2007
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Research Studies (2003)

Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia

Sarcopenia, the reduction of muscle mass and strength that occurs with aging, is widely considered one of the major causes of disability in older persons. Surprisingly, criteria that may help a clinician to ide weiter...

Author: Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, Rantanen T, Guralnik JM, Ferrucci L
Source: J Appl Physiol., 2003; 95(5): 1851-60, PMID: 14555665
GID: 1755; Last update: 02.12.2007

Research Studies (2006)

Mechanography--a new device for the assessment of muscle function in pediatrics

The development of the musculoskeletal system in children and adolescents became an important topic in the field of pediatric research when the connections between muscle force and bone diseases were revealed. weiter...

Author: Fricke O, Weidler J, Tutlewski B, Schoenau E
Source: Pediatr Res., 2006; 59(1): 46-9, PMID: 16327004
Keywords: Mechanography
GID: 304; Last update: 02.12.2007

Research Studies (2006)

Determinants of musculoskeletal frailty and the risk of falls in old age

Neuromuscular parameters that describe locomotion are indispensable variables for the diagnosis and treatment of frailty, fall risk and osteoporosis. A scientifically-based standardized locomotor assessment sho weiter...

Author: Runge M, Hunter G
Source: J Musculoskelet Neuronal Interact., 2006; 6(2): 167-73, PMID: 16849828
Keywords: Mechanography
GID: 303; Last update: 02.12.2007
More information: Original Article

Research Studies (2004)

Reproducibility of the jumping mechanography as a test of mechanical power output in physically competent adult and elderly subjects

OBJECTIVES: To compare the reproducibility of the newly developed jumping mechanography with other physical tests. DESIGN: Study 1: Repeated testing with an interval of 2 weeks to assess the short-term repetiti weiter...

Author: Rittweger J, Schiessl H, Felsenberg D, Runge M
Source: J Am Geriatr Soc., 2004; 52(1): 128-31, PMID: 14687327
Keywords: Mechanography
GID: 270; Last update: 02.12.2007

Professional Articles (2006)

Lokomotorisches Assessment / Locomotor Assessment

Einschränkungen der Fortbewegung sind die pathogenetische Endstrecke des Alterungsprozesses und vieler Erkrankungen. Die quantifizierende Messung von Bewegung gehört deshalb unverzichtbar zu einer medizinisch weiter...

Author: Runge M (Artikel aus 2006)
Source: arthritis + rheuma, 2006; 26/4: 217-224
GID: 56; Last update: 02.12.2007

Scientific Publications (2003)

Die Muskeln als Determinate des erfolgreichen Alterns

Author: Runge M
Source: MedReport, 2003; 13: 12-13
GID: 254; Last update: 01.12.2007

Fundamental Studies (2006)

Effect of primary hyperparathyroidism on volumetric bone mineral density and bone geometry assessed by peripheral quantitative computed tomography in postmenopausal women

CONTEXT: Primary hyperparathyroidism (PH) is characterized by inappropriate PTH elevation with or without hypercalcemia. Bone disease involves catabolic action at cortical sites, whereas cancellous sites and ge weiter...

Author: Charopoulos I, Tournis S, Trovas G, Raptou P, Kaldrymides P, Skarandavos G, Katsalira K, Lyritis GP
Source: J Clin Endocrinol Metab, 2006; 91(5): 1748-53, PMID: 16492695
GID: 24; Last update: 24.11.2007

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