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Case Report Med., 2009; 2009: 741087, PMID: 19710926

Side-alternating vibration training improves muscle performance in a patient with late-onset pompe disease

Year: 2009

Khan A, Ramage B, Robu I, Benard L
Medical Genetics and Pediatrics, Alberta Children"s Hospital, University of Calgary, 3rd Floor, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8.


Side-alternating vibration training (SAVT) was used for 15 weeks in a patient with Late-onset Pompe disease who had never used enzyme replacement or chaperone therapy. Prior to the use of SAVT, the patient had experienced declining muscle performance and her 6-minute walk distance decreased from 210 to 155 metres in 6 months. After SAVT, her 6-minute walk distance increased 70% from 166 to 282 metres, muscle jumping power increased by 64% from 83 to 166 watts, isometric knee extensor strength increased 17% from 38 to 44 Nm, and she achieved a more normal pattern of ankle, knee, and joint kinematics and kinetics. Her functional ability measured through the Rotterdam 9-item score was unchanged at 19/36. There were no elevations in serum creatine kinase or lactate. This is the first report, to our knowledge, of a performance improvement in a patient with Pompe disease using SAVT.

GID: 1953; Last update: 23.09.2009
More information: Original Article