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Arch Physiother 7:10. doi: 10.1186/s40945-017-0038-4, 2017; 7:10: , PMID: 29340204

Side alternating vibration training in patients with mitochondrial disease: a pilot study.

Year: 2017

Newell C, Ramage B, Robu I, Shearer J, Khan A
Department of Medical Science, Cumming School of Medicine, University of Calgary, Calgary, AB Canada.0000 0004 1936 7697grid.22072.35


Background: Side alternating vibration training (SAVT) is a mechanical oscillation using a vibrating platform that simulates exercise. We hypothesized that patients with mitochondrial myopathies, who experience muscle weakness, may see an improvement in muscle power with SAVT. Methods: Patients with mitochondrial disease started either a treatment (SAVT) or control phase (standing without vibration) for 12 weeks, then 12 weeks of washout, and then a 12-week cross-over. The main outcome measure was peak jump power (PJP). We compared this to a natural history cohort from clinic. Results: Seven out of 13 patients completed at least 80% of their SAVT sessions and were analyzed. The DeltaPJP after the control phase was -2.7 +/- 1.7 W/kg (mean +/- SEM), SAVT was +2.8 +/- 0.6 W/kg (p < 0.05) and from the natural history cohort was -2.4 +/- 0.8 W/kg/year. Conclusions: SAVT is well tolerated and may improve muscle power in mitochondrial disease patients.

GID: 4665; Last update: 19.04.2018
More information: Original Article