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European Oncology and Haematology., 2018; 14 (1): 33-39

Whole-body Vibration Training as a Supportive Therapy During Allogeneic Haematopoietic Stem Cell Transplantation – A Randomised Controlled Trial

Year: 2018

Tobias S Kaeding, Marcel Frimmel, Florian Treondlin, Klaus Jung, Wolfram Jung, Gerald Wulf, Lorenz Trümper, Justin Hasenkamp
Institute of Sport Science & University Medical Center Göttingen


Abstract: Effects of whole-body vibration (WBV) training in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) remain unknown. We examined whether additional WBV training during hospitalisation may stabilise the physical capacity of patients undergoing allogeneic HSCT, improve health-related quality of life (HRQOL) and fatigue status of these patients. In this randomised controlled trial, 26 subjects were randomly allocated 1:1 in an intervention group (INT; n=13) or a control group (CON; n=13). Patients in the CON received conventional physical therapy and patients in the INT completed further WBV training every other day. Isokinetic measurement of the muscular capacity of the lower extremities, functional endurance capacity and HRQOL were evaluated before and after the intervention period. No unwanted side effects were observed. We found a significant positive effect of the intervention on the maximum relative peak torque in extension in the INT compared to the CON (p=0.019) and patients in the INT experienced less pain (p=0.05). WBV training can be successfully implemented as a supportive therapy for patients undergoing allogeneic HSCT. Furthermore, WBV training represents a safe and effective option in the maintenance of muscular capacity of the musculature of the lower extremities and may contribute to pain release.
Keywords: Whole-body vibration training, exercise, cancer, haematopoietic stem cell transplantation, chemotherapy
Disclosure: Tobias S Kaeding, Marcel Frimmel, Florian Treondlin, Klaus Jung, Wolfram Jung, Gerald Wulf, Lorenz Trümper and Justin Hasenkamp have nothing to declare in relation to this article.
Acknowledgments: The whole-body vibration training (Board 3000) devices were provided free of charge by the manufacturer (QIONIC GmbH, Burtenbach, Germany). The authors declare no conflicts of interest, and do not have any professional relationship with the manufacturers of the devices.
Compliance with ethical guidance : This study was approved by the ethics committee of the University Medical Center Göttingen. This study was carried out following the guidelines for Good Clinical Practice (GCP) and all procedures were followed in accordance with the responsible committee on human experimentation and with the Helsinki Declaration of 1975 and subsequent revisions. All subjects provided written informed consent.
Review Process: Double-blind peer review.
Authorship: All named authors meet the criteria of the International Committee of Medical Journal Editors for authorship for this manuscript, take responsibility for the integrity of the work as a whole and have given final approval for the version to be published.
Open Access: This article is published under the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, adaptation and reproduction provided the original author(s) and source are given appropriate credit. © The Authors 2018.
Received: February 16, 2018 Accepted: April 18, 2018 Published Online: May 14, 2018
Correspondence: Tobias S Kaeding, Institute of Sports Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. E:
Support: No funding was received in the publication of this article.

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