To use our website in an optimal way, please activate JavaScript in your Browser.

J Musculoskelet Neuronal Interact, 2015; 15(2): 112-22, PMID: 26032203

Acute bone response to whole body vibration in healthy pre-pubertal boys.

Year: 2015

Harrison R, Ward K, Lee E, Razaghi H, Horne C, Bishop NJ
Academic Unit of Child Health, Sheffield Children"s Hospital, Western Bank, Sheffield, S10 2TH, UK.


The skeleton responds to mechanical stimulation. We wished to ascertain the magnitude and speed of the growing skeleton"s response to a standardised form of mechanical stimulation, vibration. 36 prepubertal boys stood for 10 minutes in total on one of two vibrating platforms (high (>2 g) or low (<1 g) magnitude vibration) on either 1, 3 or 5 successive days (n=12 for each duration); 15 control subjects stood on an inactive platform. Blood samples were taken at intervals before and after vibration to measure bone formation (P1NP, osteocalcin) and resorption (CTx) markers as well as osteoprotegerin and sclerostin. There were no significant differences between platform and control groups in bone turnover markers immediately after vibration on days 1, 3 and 5. Combining platform groups, at day 8 P1NP increased by 25.1% (CI 12.3 to 38.0; paired t-test p=0.005) and bone resorption increased by 10.9% (CI 3.6 to 18.2; paired t-test p=0.009) compared to baseline. Osteocalcin, osteoprotogerin and sclerostin did not change significantly. The growing skeleton can respond quickly to vibration of either high or low magnitude. Further work is needed to determine the utility of such "stimulation-testing" in clinical practice.

Keywords: Child, Bone, Vibration, Bone Turnover Markers, Stimulation Test
GID: 3886; Last update: 17.06.2015