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Literature (405)

Research Studies (2022)

Intermittent fasting and continuous energy restriction result in similar changes in body composition and muscle strength when combined with a 12 week resistance training program.

PURPOSE: The objective of this study was to compare the effects of 12 weeks of resistance training combined with either 5:2 intermittent fasting or continuous energy restriction on body composition, muscle size weiter...

Author: Keenan SJ, Cooke MB, Hassan EB, Chen WS, Sullivan J, Wu SX, El-Ansary D, Imani M, Belski R
Source: Eur J Nutr, 2022; 61(4): 2183-2199, PMID: 35084574
GID: 5636; Last update: 01.02.2022

Research Studies (2021)

Age-Related Declines in Lower Limb Muscle Function are Similar in Power and Endurance Athletes of Both Sexes: A Longitudinal Study of Master Athletes.

The age-related decline in muscle function, particularly muscle power, is associated with increased risk of important clinical outcomes. Physical activity is an important determinant of muscle function, and di weiter...

Author: Ireland A, Mittag U, Degens H, Felsenberg D, Heinonen A, Koltai E, Korhonen MT, McPhee JS, Mekjavic I, Pisot R, Rawer R, Radak Z, Simunic B, Suominen H, Rittweger J
Source: Calcif Tissue Int, 2021; (): , PMID: 34505170
Keywords: Master Athletes
GID: 5551; Last update: 21.09.2021
More information: Original Article

Research Studies (2021)

Mechanography assessment of fall risk in older adults: the Vietnam Osteoporosis Study.

BACKGROUND: Jumping mechanography is a technology for quantitatively assessing muscular function and balance in older adults. This study sought to define the association between jumping mechanography parameters weiter...

Author: Hoang DK, Le NM, Vo-Thi UP, Nguyen HG, Ho-Pham LT, Nguyen TV
Source: J Cachexia Sarcopenia Muscle, 2021; (): , PMID: 34196127
GID: 5464; Last update: 02.07.2021
More information: Original Article

Research Studies (2021)

Randomised controlled trial evaluating the use of Zoledronic acid in Duchenne Muscular Dystrophy.

CONTEXT: Patients with glucocorticoid dependent Duchenne Muscular Dystrophy (DMD) have increased fracture risk and reduced bone mineral density (BMD), often precipitating mobility loss. OBJECTIVE: To investigat weiter...

Author: Zacharin M, Lim A, Gryllakis J, Siafarikas A, Jefferies C, Briody J, Heather N, Pitkin J, Emmanuel J, Lee KJ, Wang X, Simm PJ, Munns CF
Source: J Clin Endocrinol Metab, 2021; (): , PMID: 33954789
GID: 5422; Last update: 10.05.2021

Research Studies (2021)

Whole-body vibration training versus conventional balance training in patients with severe COPD-a randomized, controlled trial.

BACKGROUND: Whole-body vibration training (WBV) performed on a vibration platform can significantly improve physical performance in patients with chronic obstructive pulmonary disease. It has been suggested tha weiter...

Author: Gloeckl R, Schneeberger T, Leitl D, Reinold T, Nell C, Jarosch I, Kenn K, Koczulla AR
Source: Respir Res, 2021; 22(1): 138, PMID: 33947416
Keywords: COPD, Balance, Power, Leistung, #GRFS174, #GRFS176
GID: 5420; Last update: 06.05.2021
More information: Original Article

Research Studies (2021)

Pregnancy-related change in pQCT and bone biochemistry in a population with a habitually low calcium intake.

In pregnancy, changes in maternal calcium (Ca) economy occur to satisfy fetal Ca demand. It is unclear whether maternal mineral reserves facilitate these requirements and no data exist from sub-Saharan Africa. weiter...

Author: Breasail MO, Ward KA, Schoenbuchner SM, Ceesay M, Mendy M, Jarjou LM, Moore SE, Prentice A
Source: J Bone Miner Res, 2021; 36(7): 1269-1280, PMID: 33784438
GID: 5341; Last update: 06.04.2021

Scientific Publications (2020)

Comprehensive evaluation of bone health using DXA and pQCT in an Indian boy with osteogenesis imperfecta.

We present a 9-year-old male child having history of fractures on trivial trauma with a family history of the same. He was treated for osteogenesis imperfecta (OI; zolendronate, calcium and vitamin D) and show weiter...

Author: Karguppikar MB, Ekbote V, Khadilkar A, Khadilkar V
Source: BMJ Case Rep, 2020; 13(12): , PMID: 33318265
GID: 5267; Last update: 11.01.2021

Research Studies (2020)

Ambulanter Lungensport und körperliches Training bei Patienten mit Atemwegs- und Lungenkrankheiten

DE: Um der zu selten genutzten Behandlungsoption „Bewegungstherapie“ bei Patienten mit chronischen Lungenkrankheiten eine bessere Nutzung und eine größere Verbreitung zu ermöglichen, wurden von einer Exp weiter...

Author: Worth H, Bock R, Frisch M, Göhl O, Grünig E, Glöckl R, Limbach M, Schultz K, Spielmanns M, Taube K, Teschler S, Watz H
Source: Pneumologie, 2020; DOI: 10.1055/a-1310-2400:
Keywords: Ganzkörpervibration, Galileo Studien, Metaanalysis
GID: 5258; Last update: 31.12.2020
More information: Original Article

Professional Articles (2020)

Impact of a multimodal exercise program on tibial bone health in adolescents with Development Coordination Disorder: an examination of feasibility and potential efficacy.

OBJECTIVES: Developmental coordination disorder (DCD) compromises bone health purportedly due to lower levels of physical activity. The potential of an exercise intervention to improve bone health parameters in weiter...

Author: Tan JL, Siafarikas A, Rantalainen T, Hart NH, McIntyre F, Hands B, Chivers P
Source: J Musculoskelet Neuronal Interact, 2020; 20(4): 445-471, PMID: 33265073
GID: 5245; Last update: 07.12.2020

Research Studies (2020)

Administration of Denosumab Preserves Bone Mineral Density at the Knee in Persons With Subacute Spinal Cord Injury: Findings From a Randomized Clinical Trial.

Persons with neurologically motor-complete spinal cord injury (SCI) have a marked loss of bone mineral density (BMD) of the long bones of the lower extremities, predisposing them to fragility fractures, especia weiter...

Author: Cirnigliaro CM, La Fountaine MF, Parrott JS, Kirshblum SC, McKenna C, Sauer SJ, Shapses SA, Hao L, McClure IA, Hobson JC, Spungen AM, Bauman WA
Source: JBMR Plus, 2020; 4(8): e10375, PMID: 33134767
GID: 5220; Last update: 09.11.2020

Research Studies (2020)

Impact of whole-body vibration exercise on physical performance and bone turnover in patients with monoclonal gammopathy of undetermined significance.

Objective: Monoclonal Gammopathy of Undetermined Significance (MGUS) is a risk factor for reduced physical performance, osteoporosis, and fractures due to compromised musculoskeletal metabolism. In this conditi weiter...

Author: Seefried L, Genest F, Stromsdorfer J, Engelmann B, Lapa C, Jakob F, Baumann FT, Sperlich B, Jundt F
Source: J Bone Oncol, 2020; 25(): 100323, PMID: 33083217
GID: 5211; Last update: 26.10.2020
More information: Original Article

Scientific Publications (2020)

Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women.

BACKGROUND: Osteoporosis affects elderly patients of both sexes. It is characterized by an increased fracture risk due to defective remodeling of the bone microarchitecture. It affects in particular postmenopau weiter...

Author: Jackle K, Kolb JP, Schilling AF, Schlickewei C, Amling M, Rueger JM, Lehmann W
Source: BMC Musculoskelet Disord, 2020; 21(1): 693, PMID: 33076902
GID: 5212; Last update: 26.10.2020

Research Studies (2020)

Radiographic imaging, densitometry and disease severity in Autosomal dominant osteopetrosis type 2.

OBJECTIVE: To characterize relationships between quantitative computed tomography bone mineral density measurements and other qualitative and quantitative imaging measures, as well as clinical metrics, in pati weiter...

Author: Ladd LM, Imel EA, Niziolek PJ, Liu Z, Warden SJ, Liang Y, Econs MJ
Source: Skeletal Radiol, 2020; 50(5): 903-913, PMID: 33009917
GID: 5204; Last update: 05.10.2020

Research Studies (2020)

Peripheral quantitative computed tomography (pQCT) in 12- and 24-month-old children - Practical aspects and descriptive data.

BACKGROUND: Peripheral quantitative computed tomography (pQCT) is a useful tool to assess detailed bone characteristics. Its utility in infants is however limited due to lack of reference data and technical cha weiter...

Author: Valkama S, Holmlund-Suila E, Ireland A, Hauta-Alus H, Enlund-Cerullo M, Rosendahl J, Andersson S, Makitie O
Source: Bone, 2020; 141(): 115670, PMID: 33007527
GID: 5205; Last update: 05.10.2020

Scientific Publications (2020)

Loss of bone density and bone strength following premenopausal risk-reducing bilateral salpingo-oophorectomy: a prospective controlled study (WHAM Study).

Prophylactic oophorectomy is recommended for women at high risk for ovarian cancer, but the associated impact on bone health is of clinical concern. This prospective, controlled study demonstrated substantial l weiter...

Author: Jiang H, Robinson DL, Lee PVS, Krejany EO, Yates CJ, Hickey M, Wark JD
Source: Osteoporos Int, 2020; (): , PMID: 32856124
Keywords: DXA . Finite element analysis . Hormone replacement . pQCT . Surgical menopause
GID: 5186; Last update: 31.08.2020

Research Studies (2020)

Associations between Physical Fitness, Bone Mass, and Structure in Older People.

The main aim was to analyse the associations between several physical fitness variables and bone parameters in a sample of elderly people. 129 participants (94 females and 35 males, 76.2 +/- 5.4 y) from the EXE weiter...

Author: Moradell A, Gomez-Cabello A, Gomez-Bruton A, Muniz-Pardos B, Puyalto JM, Matute-Llorente A, Gonzalez-Aguero A, Ara I, Casajus JA, Vicente-Rodriguez G
Source: Biomed Res Int, 2020; 2020(): 6930682, PMID: 32733950
GID: 5183; Last update: 25.08.2020

Scientific Publications (2020)

Total urinary polyphenols and longitudinal changes of bone properties. The InCHIANTI study.

The aim of this study was to evaluate the association of levels of urinary total polyphenols considered as a proxy measure of polyphenol intake, with longitudinal changes of bone properties, in the InCHIANTI s weiter...

Author: Di Iorio A, Abate M, Bandinelli S, Barassi G, Cherubini A, Andres-Lacueva C, Zamora-Ros R, Paganelli R, Volpato S, Ferrucci L
Source: Osteoporos Int, 2020; (): , PMID: 32793995
GID: 5179; Last update: 25.08.2020

Scientific Publications (2020)

Naturally occurring stable calcium isotope ratios in body compartments provide a novel biomarker of bone mineral balance in children and young adults.

Serum calcium (Ca), bone biomarkers and radiological imaging do not allow accurate evaluation of bone mineral balance (BMB), a key determinant of bone mineral density (BMD) and fracture risk. We studied natural weiter...

Author: Shroff R, Fewtrell M, Heuser A, Kolevica A, Lalayiannis A, McAlister L, Silva S, Goodman N, Schmitt CP, Biassoni L, Rahn A, Fischer DC, Eisenhauer A
Source: J Bone Miner Res, 2020; (): , PMID: 32786145
GID: 5181; Last update: 25.08.2020

Research Studies (2020)

Bone Geometry and Microarchitecture Deficits in Children with Alagille Syndrome.

Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture of unknown etiology. Our object weiter...

Author: Kindler JM, Mitchell EL, Piccoli DA, Grimberg A, Leonard MB, Loomes KM, Zemel BS
Source: Bone, 2020; 141(): 115576, PMID: 32791330
GID: 5180; Last update: 25.08.2020

Research Studies (2020)

Influence of Changes in Soft Tissue Composition on Changes in Bone Strength in Peri-Pubertal Girls: The STAR Longitudinal Study.

Obesity and osteoporosis remain two major public health concerns. Soft tissue composition and bone are interrelated; however, it is still not well understood how changes in adiposity during adolescence affect b weiter...

Author: Bland VL, Bea JW, Blew RM, Roe DJ, Lee VR, Funk JL, Going SB
Source: J Bone Miner Res, 2020; (): , PMID: 32810295
GID: 5174; Last update: 24.08.2020

Research Studies (2020)

Association of objectively measured physical activity and bone health in children and adolescents: a systematic review and narrative synthesis.

The influence of day-to-day physical activity on bone in adolescence has not been well characterized. Forty articles were identified that assessed the relationship between accelerometry-derived physical activit weiter...

Author: Bland VL, Heatherington-Rauth M, Howe C, Going SB, Bea JW
Source: Osteoporos Int, 2020; 31(10): 1865-1894, PMID: 32542544
GID: 5148; Last update: 22.06.2020

Research Studies (2020)

Pediatric Reference Ranges for Ultradistal Radius Bone Density: Results from the Bone Mineral Density in Childhood Study.

CONTEXT: The ultradistal (UD) radius is rich in trabecular bone and is easily measured by dual energy X-ray absorptiometry (DXA). UD radius areal bone mineral density (aBMD) may help identify trabecular bone d weiter...

Author: Kindler JM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield S, Shepherd JA, Kelly A, Winer KK, Zemel BS
Source: J Clin Endocrinol Metab, 2020; 105(10): 3529-3539, PMID: 32561914
GID: 5147; Last update: 22.06.2020

Fundamental Studies (2020)

Analysis of low-dose estrogen on fracture healing measured by pQCT in postmenopausal women

Background The skeletal disease osteoporosis affects primarily postmenopausal women. It is characterized by increased fracture risk due to defective remodeling of bone tissue and a pathological bone microarchi weiter...

Author: Katharina Blanka Dr. Jäckle, Jan Philipp Kolb, Arndt F Schilling
Source: PREPRINT (Version 1) available at Research Square [+https://doi.org/10.21203/rs.3.rs-29939/v1+], 2020;
Keywords: estrogen, fracture healing, osteoporosis, callus formation
GID: 5144; Last update: 16.06.2020

Scientific Publications (2020)

Physical function and lean body mass as predictors of bone loss after hip fracture: a prospective follow-up study.

BACKGROUND: Predictors of bone deterioration after hip fracture have not been well characterized. The aim of this study was to examine the associations of physical function and lean body mass (LBM) with loss of weiter...

Author: Suominen TH, Edgren J, Salpakoski A, Kallinen M, Cervinka T, Rantalainen T, Tormakangas T, Heinonen A, Sipila S
Source: BMC Musculoskelet Disord, 2020; 21(1): 367, PMID: 32517755
Keywords: Aging, Bone mineral density, Hip fracture, Lean body mass, Physical function, pQCT
GID: 5140; Last update: 15.06.2020

Research Studies (2020)

Are jumping mechanography assessed muscle force and power, and traditional physical capability measures associated with falls in older adults? Results from the Hertfordshire Cohort Study.

OBJECTIVES: To explore associations between measures of lower limb muscle force, velocity and power from jumping mechanography (JM) and simple physical capability (PC) testing, and falls in community dwelling weiter...

Author: Parsons CM, Edwards MH, Cooper C, Dennison EM, Ward KA
Source: J Musculoskelet Neuronal Interact, 2020; 20(2): 168-175, PMID: 32481232
Keywords: Ageing, Epidemiology, Falls, Jump, Muscle, Physical Capability, Leonardo Mechanography, Fall Risk
GID: 5132; Last update: 05.06.2020

Research Studies (2019)

Evaluation of physical performance in musculoskeletal and rheumatic diseases with jumping mechanography.

Objective: Low muscle function is a component of sarcopenia. Rheumatic and musculoskeletal diseases are related to increased muscle loss and decreased muscle performance. Our purpose was to study muscle functio weiter...

Author: Dionyssiotis Y, Skarantavos G, Kantaidou I, Papadatou MC, Papagelopoulos P, Angoules A, Papathanasiou J, Lyritis GP
Source: J Frailty Sarcopenia Falls, 2019; 4(4): 116-121, PMID: 32300726
Keywords: Sarcopenia, Jumping mechanography, Rheumatic diseases, Osteoporosis, Menopause
GID: 5133; Last update: 05.06.2020

Scientific Publications (2020)

Bone Densities and Bone Geometry in Children and Adolescents With Arthrogryposis

Objective: To describe bone densitometry results using lumbar spine dual-energy X-ray absorptiometry and forearm peripheral quantitative computed tomography (pQCT) in children with arthrogryposis multiplex cong weiter...

Author: Noemi Dahan-Oliel 1 , Jessica Collins 2 , Damian Rauch 2 , Gloria Bukovy 2 , Reggie Hamdy 3 , Frank Rauch 4
Source: Bone, 2020; 137: 115454, PMID: 32464275
Keywords: Arthrogryposis; Bone mineral density; Children; Fat and muscle mass.
GID: 5128; Last update: 03.06.2020

Research Studies (2019)

Gender specific paediatric reference data for muscle function parameters assessed using jumping mechanography

Objective: Bone adapts to mechanical stimuli by increasing its mass and changing geometry; muscles are the stimulators for this change as they induce forces through contractions. Thus, bone strength is driven b weiter...

Author: Palande S., Ekbote V., Chiplonkar S., Padidela R., Mughal Z., Vispute S., Rawer R., Khadilkar A., Khadilkar V.
Source: Bone Abstracts (ICCBH 2019), 2019; 10.1530/boneabs.7.P155: 155
GID: 5124; Last update: 30.05.2020
More information: Original Article

Research Studies (2020)

The Effects of 20 Weeks of Side-Alternating Vibration Therapy on Physical Function, Bone and Muscle Health in Adolescents With Down Syndrome

Aims: To evaluate the effects of side-alternating vibration therapy on physical function and body composition in adolescents with Down syndrome.Methods: Fourteen adolescents (8 males) with Down syndrome (mean weiter...

Author: Silmara Gusso, Renuka M Vesey, José G B Derraik, Craig F Munns, Patricia Colle , Janene B Biggs, Paul L Hofman
Source: Phys Occup Ther Pediatr, 2020; 28: 1-12, PMID: 32345083
Keywords: BMC, Down Syndrome, muscle function, vibration plate
#GRFS169
GID: 5121; Last update: 26.05.2020

Research Studies (2020)

Safety, Feasibility and Efficacy of Side-Alternating Vibration Therapy on Bone and Muscle Health in Children and Adolescents With Musculoskeletal Disorders: A Pilot Trial

Aims: A pilot study was performed to establish the safety, feasibility and efficacy of vibration therapy (VT) on bone and muscle health in children and adolescents with a range of musculoskeletal disorders. M weiter...

Author: Renuka M Vesey , Paul L Hofman , José Gb Derraik, Patrícia Colle, Janene B Biggs, Craig F Munns, Wayne S Cutfield, Silmara Gusso
Source: J Paediatr Child Health, 2020; 56(8): 1257-1262, PMID: 32436612
Keywords: bone; muscle; musculoskeletal disorder; physical function; vibration plate.
GID: 5118; Last update: 26.05.2020

Research Studies (2020)

Manual of Vibration Exercise and Vibration Therapy

This book addresses the practical aspects of vibration exercise and vibration therapy. In addition, it describes the technical and physiological background, providing applied scientists and doctors with a deepe weiter...

Author: Rittweger J., van der Zee E.A., Rawer R., Riley D.A., Cochrane D., Ribor-Ciscar E., Ritzmann R., Karcan I., Moreira-Marconi E., Marín P., Patrick O.J., Stark C., Runge M., Bremben D., Gloeckl R., Duran I., Yang F., Gerhardt F., Paineiras-Domingos L.L., Lo
Source: Springer, ISBN 978-3-030-43985-9, 2020;
GID: 5115; Last update: 25.05.2020
More information: Original Article

Professional Articles (2020)

Effects of supervised high-intensity resistance and impact training or machine-based isometric training on regional bone geometry and strength in middle-aged and older men with low bone mass: The LIFTMOR-M semi-randomised controlled trial.

INTRODUCTION: Few data exist on the effects of bone-targeted exercise on geometric and biomechanical indices of bone strength in men. The Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation weiter...

Author: Harding AT, Weeks BK, Lambert C, Watson SL, Weis LJ, Beck BR
Source: Bone, 2020; 136: 115263, PMID: 32289518
GID: 5095; Last update: 20.04.2020

Scientific Publications (2020)

25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D, and Peripheral Bone Densitometry in Adults with Celiac Disease.

Background: Adults with celiac disease (CeD) show low bone mineral density (BMD) and high fracture risk. CeD guidelines suggest measurements of serum minerals and vitamin D. However, studies on vitamin levels weiter...

Author: Ciacci C, Bilancio G, Russo I, Iovino P, Cavallo P, Santonicola A, Bucci C, Cirillo M, Zingone F
Source: Nutrients, 2020; 12(4): 929, PMID: 32230847
GID: 5090; Last update: 06.04.2020

Professional Articles (2020)

High Impact Physical Activity and Bone Health of Lower Extremities in Childhood Cancer Survivors: A Cross-sectional Study of SURfit.

Childhood cancer survivors (CCS) are at risk of reduced bone health and premature osteoporosis. As physical activity with high impact loading (IL-PA) is known to promote bone health, we compared bone densitomet weiter...

Author: Zurcher SJ, Jung R, Monnerat S, Schindera C, Eser P, Meier C, Rueegg CS, von der Weid NX, Kriemler S
Source: Int J Cancer, 2020; (): , PMID: 32167159
GID: 5077; Last update: 16.03.2020

Fundamental Studies (2020)

Site-Specific Effects of Swimming on Bone Density in Female Collegiate Swimmers.

While swimming provides numerous cardiovascular and overall health benefits, past research suggests it provides no constructive benefits to bone strength and density at dual energy x-ray absorptiometry (DXA) me weiter...

Author: Miller M, Kojetin S, Scibora L
Source: Int J Exerc Sci, 2020; 13(1): 249-259, PMID: 32148613
GID: 5078; Last update: 16.03.2020

Research Studies (2020)

The impact of sensory and/or sensorimotor neuropathy on lower limb muscle endurance, explosive and maximal muscle strength in patients with type 2 diabetes mellitus.

AIMS: The purpose of this study was to investigate the impact of diabetic neuropathy (dNP) on lower limb endurance, explosive and maximal muscle strength in patients with Type 2 Diabetes Mellitus (T2DM). METHOD weiter...

Author: Van Eetvelde BLM, Lapauw B, Proot P, Vanden Wyngaert K, Celie B, Cambier D, Calders P
Source: J Diabetes Complications, 2020; 34(6): 107562, PMID: 32122790
Keywords: Type 2 diabetes mellitus Diabetic neuropathy Maximal muscle strength Muscle endurance Explosive muscle strength
GID: 5079; Last update: 16.03.2020

Research Studies (2020)

Characterisation of peripheral bone mineral density in youth at risk of secondary osteoporosis - a preliminary insight.

OBJECTIVES: To describe peripheral long bone material and structural differences in youth at risk of secondary osteoporosis across disease-specific profiles. METHODS: Upper- and lower limbs of children and ado weiter...

Author: Jenkins M, Hart NH, Nimphius S, Chivers P, Rantalainen T, Rothacker KM, Beck BR, Weeks BK, McIntyre F, Hands B, Beeson BP, Siafarikas A
Source: J Musculoskelet Neuronal Interact, 2020; 20(1): 27-52, PMID: 32131368
GID: 5074; Last update: 11.03.2020

Research Studies (2020)

Deficits in bone architecture and strength in children living with HIV on antiretroviral therapy.

BACKGROUND: Reduced bone mineral mass by dual x-ray absorptiometry (DXA) is reported in children living with HIV (CLWH), but few studies of bone microarchitecture, particularly in sub-Saharan Africa, have been weiter...

Author: Shiau S, Yin MT, Strehlau R, Burke M, Patel F, Kuhn L, Coovadia A, Norris SA, Arpadi SM
Source: J Acquir Immune Defic Syndr, 2020; 84(1): 101-106, PMID: 32141960
GID: 5070; Last update: 10.03.2020

Professional Articles (2020)

Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: The Cardiovascular Risk in Young Finns Study.

BACKGROUND: Studies have shown that osteoporosis and atherosclerosis are comorbid conditions sharing common risk factors and pathophysiological mechanisms. Understanding these is crucial in order to develop sha weiter...

Author: Mishra BH, Mishra PP, Mononen N, Hilvo M, Sievanen H, Juonala M, Laaksonen M, Hutri-Kahonen N, Viikari J, Kahonen M, Raitakari OT, Laaksonen R, Lehtimaki T
Source: Bone, 2020; 131(): 115160, PMID: 31759205
GID: 5050; Last update: 27.02.2020

User Reports (2020)

Bone health in adolescents with idiopathic scoliosis.

AIMS: Idiopathic scoliosis is the most common spinal deformity in adolescents and children. The aetiology of the disease remains unknown. Previous studies have shown a lower bone mineral density in individuals weiter...

Author: Diarbakerli E, Savvides P, Wihlborg A, Abbott A, Bergstrom I, Gerdhem P
Source: Bone Joint J, 2020; 102-B(2): 268-272, PMID: 32009439
GID: 5042; Last update: 11.02.2020

Research Studies (2020)

Self-reported Sleep Quality and Bone Outcomes in Older Adults: Findings from the Hertfordshire Cohort Study.

Sleep duration may be associated with risk of osteoporosis, with suggestions that too little or indeed too much sleep may be detrimental to bone health. In this study, we considered whether perceived sleep qual weiter...

Author: Bevilacqua G, Denison HJ, Laskou F, Jameson KA, Ward KA, Cooper C, Dennison EM
Source: Calcif Tissue Int, 2020; 106(5): 455-464, PMID: 31955228
GID: 5027; Last update: 20.01.2020

Research Studies (2020)

Feasibility and Effects on Muscle Function of an Exercise Program for Older Adults.

INTRODUCTION: Study objective was to determine feasibility and compliance with a 3-month exercise intervention in older adults, and if peripheral quantitative computed tomography muscle measures and jumping me weiter...

Author: Minett MM, Binkley TL, Holm RP, Runge M, Specker BL
Source: Med Sci Sports Exerc, 2020; 52(2): 441-448, PMID: 31939912
GID: 5028; Last update: 20.01.2020

Research Studies (2019)

BIA-assessed cellular hydration and muscle performance in youth, adults, and older adults.

BACKGROUND & AIMS: Alterations in body hydration can have an impact on muscle performance, with consequences not only at a sporting level, but on overall health and daily functional competence. Given that t weiter...

Author: Hetherington-Rauth M, Baptista F, Sardinha LB
Source: Clin Nutr, 2019; 39(8): 2624-2630, PMID: 31837838
GID: 5030; Last update: 20.01.2020

Research Studies (2020)

Effects of Whole-Body Vibration Training and Blood Flow Restriction on Muscle Adaptations in Women: A Randomized Controlled Trial.

Centner, C, Ritzmann, R, Gollhofer, A, and Konig, D. Effects of whole-body vibration training and blood flow restriction on muscle adaptations in women: a randomized controlled trial. J Strength Cond Res XX(X): weiter...

Author: Centner C, Ritzmann R, Gollhofer A, Konig D
Source: J Strength Cond Res, 2020; 34(3): 603-608, PMID: 31842133
GID: 5014; Last update: 14.01.2020

Professional Articles (2019)

Low Muscle Density is Associated with Deteriorations in Muscle Strength and Physical Functioning in Rheumatoid Arthritis.

PURPOSE: Rheumatoid arthritis (RA) is associated with low muscle density due to accumulation of intramuscular fat. This study identified predictors of changes in muscle density and determined whether low muscle weiter...

Author: Baker JF, Mostoufi-Moab S, Long J, Taratuta E, Leonard MB, Zemel B
Source: Arthritis Care Res (Hoboken), 2019; (): , PMID: 31841259
GID: 5021; Last update: 14.01.2020

Research Studies (2020)

Balance Performance across the Lifespan Assessed by the Leonardo Mechanograph®: A Cross-Sectional Study

Reference values of sway parameters have not been published for the Leonardo mechanograph® so far. The aim of this cross-sectional study was to determine normative values on postural control measured by the fo weiter...

Author: Wiegmann S, Felsenberg D, Gast U, Börst H, Armbrecht G, Dietzel R
Source: J. Funct. Morphol. Kinesiol., 2020; 5(1): doi:10.3390/jfmk5010, PMID: 33467217
Keywords: Balance
GID: 5007; Last update: 20.12.2019
More information: Original Article

Scientific Publications (2020)

Bone health in women with a history of gestational diabetes or obesity.

INTRODUCTION: Type 2 diabetes is associated with an increased risk of bone fractures. However, bone health of women with a history of gestational diabetes (GDM) has received little attention. This cross-section weiter...

Author: Engberg E, Koivusalo SB, Huvinen E, Viljakainen H
Source: Acta Obstet Gynecol Scand, 2020; 99 (4): 477-487, PMID: 31784976
GID: 5000; Last update: 02.12.2019

Professional Articles (2020)

Bone geometry and lower extremity bone stress injuries in male runners.

Bone stress injuries (BSI) are common among distance runners and research investigations examining risk factors for BSI among men are limited. Therefore, investigations are needed to determine if men with a his weiter...

Author: Popp KL, Frye AC, Stovitz SD, Hughes JM
Source: J Sci Med Sport, 2020; 23(2): 145-150, PMID: 31594711
GID: 4984; Last update: 14.10.2019

Fundamental Studies (2020)

A rare mutation in SMAD9 associated with high bone mass identifies the SMAD-dependent BMP signalling pathway as a potential anabolic target for osteoporosis.

Novel anabolic drug targets are needed to treat osteoporosis. Having established a large national cohort with unexplained high bone mass (HBM), we aimed to identify a novel monogenic cause of HBM and provide i weiter...

Author: Gregson CL, Bergen D, Leo P, Sessions RB, Wheeler L, Hartley A, Youlten S, Croucher PI, McInerney-Leo AM, Fraser W, Tang JCY, Anderson L, Marshall M, Sergot L, Paternoster L, Davey-Smith G, Brown MA, Hammond C, Kemp JP, Tobias JH, Duncan EL
Source: J Bone Miner Res, 2020; 35(1): 92-105, PMID: 31525280
GID: 4977; Last update: 26.09.2019

Scientific Publications (2020)

Effect of rheumatoid arthritis and age on metacarpal bone shaft geometry and density: A longitudinal pQCT study in postmenopausal women.

OBJECTIVE: This study aimed to elucidate the effects of changes in the geometry and density of the metacarpal bone of patients with rheumatoid arthritis (RA). METHODS: This prospective study included consecutiv weiter...

Author: Aeberli D, Fankhauser N, Zebaze R, Bonel H, Moller B, Villiger PM
Source: Semin Arthritis Rheum, 2020; 50(2): 220-227, PMID: 31466837
GID: 4961; Last update: 02.09.2019

Research Studies (2019)

Effects of a Home-Based Physical Rehabilitation Program on Tibial Bone Structure, Density, and Strength After Hip Fracture: A Secondary Analysis of a Randomized Controlled Trial.

Weight-bearing physical activity may decrease or prevent bone deterioration after hip fracture. This study investigated the effects of a home-based physical rehabilitation program on tibial bone traits in older weiter...

Author: Suominen TH, Edgren J, Salpakoski A, Arkela M, Kallinen M, Cervinka T, Rantalainen T, Tormakangas T, Heinonen A, Sipila S
Source: JBMR Plus, 2019; 3(6): e10175, PMID: 31346568
GID: 4946; Last update: 20.08.2019

Professional Articles (2019)

pQCT bone geometry and strength: population epidemiology and concordance in Australian children aged 11-12 years and their parents.

OBJECTIVES: To describe the epidemiology and concordance of bone health in a population-based sample of Australian parent-child dyads at child age 11-12 years. DESIGN: Population-based cross-sectional study (th weiter...

Author: Vlok J, Simm PJ, Lycett K, Clifford SA, Grobler AC, Lange K, Ismail N, Osborn W, Wake M
Source: BMJ Open, 2019; 9(Suppl 3): 63-74, PMID: 31273017
GID: 4939; Last update: 08.07.2019

Scientific Publications (2019)

Pentosidine Is Associated With Cortical Bone Geometry and Insulin Resistance in Otherwise Healthy Children.

Pentosidine is an advanced glycation end product (AGE) associated with fracture in adults with diabetes. AGE accumulation in bone collagen contributes to bone fragility but might also adversely influence bone t weiter...

Author: Kindler JM, Laing EM, Liu W, Dain JA, Lewis RD
Source: J Bone Miner Res, 2019; 34(8): 1446-1450, PMID: 31220375
GID: 4934; Last update: 01.07.2019

Research Studies (2019)

A multi-imaging modality study of bone density, bone structure and the muscle - bone unit in end-stage renal disease.

End stage renal disease (ESRD) is associated with sarcopenia and skeletal fragility. The objectives of this cross-sectional study were to (1) characterize body composition, bone mineral density (BMD) and bone weiter...

Author: Leonard MB, Wehrli FW, Ziolkowski SL, Billig E, Long J, Nickolas TL, Magland JF, Nihtianova S, Zemel BS, Herskovitz R, Rajapakse CS
Source: Bone, 2019; 127(): 271-279, PMID: 31158505
GID: 4917; Last update: 17.06.2019

Scientific Publications (2019)

Bone mineral density, structure, distribution and strength in men with prostate cancer treated with androgen deprivation therapy.

Androgen deprivation therapy (ADT) improves survival in men with advanced prostate cancer (PCa), but has been associated with compromised skeletal health and increased fracture risk. However, limited previous r weiter...

Author: Via JD, Daly RM, Owen PJ, Mundell NL, Rantalainen T, Fraser SF
Source: Bone, 2019; 127(): 367-375, PMID: 31189088
GID: 4926; Last update: 17.06.2019

Research Studies (2015)

Age-Related Loss of Muscle Mass, Strength, and Power and Their Association With Mobility in Recreationally-Active Older Adults in the United Kingdom.

To investigate reasons for the age-related reduction in physical function, we determined the relationships between muscle size, strength, and power with 6-min walk distance (6MWD) and timed up-and-go performan weiter...

Author: Maden-Wilkinson TM, McPhee JS, Jones DA, Degens H
Source: J Aging Phys Act, 2015; 23(3): 352-60, PMID: 25007824
GID: 4905; Last update: 21.05.2019
More information: Original Article

Research Studies (2020)

Testing the deconditioning hypothesis of low back pain: A study in 1182 older women.

This study assessed the deconditioning hypothesis of low back pain (LBP) by examining physical function in relation to LBP and self-reported physical activity in women. This cross-sectional study recruited a re weiter...

Author: Tagliaferri SD, Armbrecht G, Miller CT, Owen PJ, Mundell NL, Felsenberg D, Thomasius F, Belavy DL
Source: Eur J Sport Sci, 2020; 20(1): 17-23, PMID: 31012382
GID: 4899; Last update: 29.04.2019

Research Studies (2019)

Type 1 diabetes onset at young age is associated with compromised bone quality.

Women with type 1 diabetes (T1D) are at increased risk for fracture. We studied the association of T1D and young age at T1D onset (T1D onset before 20years) on bone structural quality. 24 postmenopausal women w weiter...

Author: Shah VN, Joshee P, Sippl R, Pyle L, Vigers T, Carpenter D, Kohrt W, Snell-Bergeon JK
Source: Bone, 2019; 123(): 260-264, PMID: 30936041
GID: 4887; Last update: 08.04.2019

Research Studies (2019)

Calcium and vitamin D supplementation and bone health in Marine recruits: Effect of season.

Stress fractures are common overuse injuries caused by repetitive bone loading. These fractures are of particular concern for military recruits and athletes resulting in attrition in up to 60% of recruits that weiter...

Author: Gaffney-Stomberg E, Nakayama AT, Guerriere KI, Lutz LJ, Walker LA, Staab JS, Scott JM, Gasier HG, McClung JP
Source: Bone, 2019; 123(): 224–233, PMID: 30902791
GID: 4885; Last update: 01.04.2019

Research Studies (2019)

Evaluation of long-term functional donor-site morbidity after deep circumflex iliac crest artery bone flap harvest.

PURPOSE: Free flap surgery can be associated with donor-site morbidity. The purpose of this study was to analyze long-term functional outcomes at the donor site after deep circumflex iliac artery (DCIA) bone fl weiter...

Author: Rendenbach C, Goehler F, Hansen L, Kohlmeier C, Amling M, Hanken H, Beck-Broichsitter B, Heiland M, Riecke B
Source: Microsurgery, 2019; 39(4): 304-309, PMID: 30159928
GID: 4877; Last update: 11.03.2019

Research Studies (2019)

Application of current sarcopenia definitions in spinal cord injury

Objective: Little is known about how appropriate the working definitions of sarcopenia are in subjects with spinal cord injury (SCI). This study aimed to evaluate the application of current sarcopenia definitio weiter...

Author: Yannis Dionyssiotis, Grigorios Skarantavos, Konstantina Petropoulou, Antonios Galanos,Christina-Anastassia Rapidi, George P. Lyritis
Source: J Musculoskelet Neuronal Interact, 2019; 1(19): 21-29, PMID: 30839300
Keywords: Sarcopenia, Spinal Cord Injury, Cross Sectional Muscle Area, pQCT, Whole Body DXA
GID: 4865; Last update: 28.02.2019

Research Studies (2019)

Childhood exposure to passive smoking and bone health in adulthood. The Cardiovascular Risk in Young Finns Study.

Context: Passive smoke exposure has been linked with the risk of osteoporosis in adults. Objective: We aimed to examine the independent effects of exposure to passive smoking in childhood on adult bone health. weiter...

Author: Juonala M, Pitkanen N, Tolonen S, Laaksonen M, Sievanen H, Jokinen E, Laitinen T, Sabin MA, Hutri-Kahonen N, Lehtimaki T, Taittonen L, Jula A, Loo BM, Impivaara O, Kahonen M, Magnussen CG, Viikari JSA, Raitakari OT
Source: J Clin Endocrinol Metab, 2019; 104(6): 2403-2411, PMID: 30715377
GID: 4854; Last update: 13.02.2019

Research Studies (2019)

Acute Neuromuscular Modulation Enhances Postural Control after Whole-Body Vibration

The postural movement control determines performance of almost any kind of human movement. The current study aimed to investigate whether a short bout of whole-body vibration (WBV) can improve postural control. weiter...

Author: Krause A, Ritzmann R, Lee K, Freyler K, Gollhofer A
Source: GERMAN JOURNAL OF SPORTS MEDICINE, 2019; 70(1): 5-12
Keywords: Postural Control, Balance, Leonardo
#GRFS158
GID: 4838; Last update: 05.02.2019
More information: Original Article

Research Studies (2019)

Glucocorticoids and body fat inversely associate with bone marrow density of the distal radius in healthy youths

Background Elevated bone marrow adipose tissue (BMAT) is associated with lower bone quality, higher fracture rates, and an unfavorable overall metabolic profile. Apart from older age, particularly glucocortico weiter...

Author: Jonas Esche Lijie Shi Michaela F Hartmann Eckhard Schönau Stefan A Wudy Thomas Remer
Source: The Journal of Clinical Endocrinology & Metabolism, jc., 2019; 104(6): 2250-2256, PMID: 30715368
GID: 4841; Last update: 05.02.2019

Research Studies (2019)

Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiative.

BACKGROUND: Lower skeletal muscle density, indicating greater infiltration of adipose tissue into muscles, is associated with higher fracture risk in older adults. We aimed to determine whether mid-calf muscle weiter...

Author: Scott D, Johansson J, McMillan LB, Ebeling PR, Nordstrom A, Nordstrom P
Source: Bone, 2019; 120(): 446-451, PMID: 30537557
Keywords: pACT, Muscle Density, Activity
GID: 4820; Last update: 10.01.2019

Scientific Publications (2018)

Assessment of Bone and Muscle Measurements by Peripheral Quantitative Computed Tomography in Geriatric Patients.

The loss of bone and muscle mass increases the risk of osteoporotic fractures. Dual energy X-ray absorptiometry (DXA) loses sensitivity in older age. The purpose of this study was to evaluate bone and muscle me weiter...

Author: Drey M, Henkel M, Petermeise S, Weiss S, Ferrari U, Rottenkolber M, Schmidmaier R
Source: J Clin Densitom, 2018; (): , PMID: 30425007
GID: 4803; Last update: 19.11.2018

Research Studies (2018)

Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies - a randomized controlled pilot study.

BACKGROUND: Hospitalized cancer patients undergoing intensive or high-dose chemotherapy often experience a considerable decline in functional performance associated with the increased risk of adverse health eve weiter...

Author: Pahl A, Wehrle A, Kneis S, Gollhofer A, Bertz H
Source: BMC Cancer, 2018; 18(920): , PMID: 30253746
Keywords: Onkologoie, Cancer, ChemoTherapy
#GRFS158
GID: 4774; Last update: 15.10.2018
More information: Original Article

Research Studies (2018)

Associations of fluoride intake with children"s cortical bone mineral and strength measures at age 11.

OBJECTIVES: There is strong affinity between fluoride and calcium, and mineralized tissues. Investigations of fluoride and bone health during childhood and adolescence show inconsistent results. This analysis weiter...

Author: Levy SM, Eichenberger-Gilmore JM, Warren JJ, Kavand G, Letuchy E, Broffitt B, Marshall TA, Burns TL, Janz KF, Pauley C, Torner JC, Phipps K
Source: J Public Health Dent, 2018; 78(4): 352-359, PMID: 30155933
GID: 4750; Last update: 03.09.2018

Research Studies (2018)

Circum-menarcheal bone acquisition is stress-driven: A longitudinal study in adolescent female gymnasts and non-gymnasts.

Mechanical loading through youth exercise is highly modifiable and represents a strategy to maximize peak adult bone mass, with the potential for broad implementation across the population to lower fracture ris weiter...

Author: Troy KL, Scerpella TA, Dowthwaite JN
Source: J Biomech, 2018; 78(): 45-51, PMID: 30055842
GID: 4745; Last update: 29.08.2018

Research Studies (2018)

Persistence of muscle-bone deficits following anti-tumor necrosis factor therapy in adolescents with crohn"s disease.

OBJECTIVES: To assess change in the muscle-bone unit in adolescents with Crohn"s disease (CD) on anti-tumor necrosis factor (anti-TNFalpha). METHODS: Prospective study following anti-TNFalpha in 19 adolescent weiter...

Author: Altowati MMA, Shepherd S, McMillan M, McGrogan P, Russell R, Ahmed SF, Wong SC
Source: J Pediatr Gastroenterol Nutr, 2018; 67(6): 738-744, PMID: 30052566
GID: 4747; Last update: 29.08.2018

Scientific Publications (2018)

Suboptimal bone status for adolescents with low motor competence and developmental coordination disorder-It"s sex specific.

BACKGROUND: Australian adolescents with low motor competence (LMC) have higher fracture rates and poorer bone health compared to European normative data, but currently no normative data exists for Australians. weiter...

Author: Chivers P, Rantalainen T, McIntyre F, Hands B, Weeks B, Beck B, Sophia N, Hart N, Siafarikas A
Source: Res Dev Disabil, 2018; S0891-4222(18): 30179-3, PMID: 30119956
GID: 4738; Last update: 21.08.2018

Research Studies (2018)

Low physical performance determined by chair rising test muscle mechanography is associated with prevalent fragility fractures.

This study examined associations between physical performance assessed by chair rising test muscle mechanography and DXA T-score as well as body composition in a large patient cohort. Next to various significan weiter...

Author: Rupp T, Butscheidt S, Jahn K, Simon MJ, Mussawy H, Oheim R, Barvencik F, Amling M, Rolvien T
Source: Arch Osteoporos, 2018; 13(1): 71, PMID: 29968169
GID: 4735; Last update: 24.07.2018

Scientific Publications (2018)

Changes in bone microarchitecture following kidney transplantation - beyond bone mineral density.

Bone disease in kidney transplant recipients (KTRs) is characterised by bone mineral density (BMD) loss but bone microarchitecture changes are poorly defined. In this prospective cohort study, we evaluated bone weiter...

Author: Sharma AK, Toussaint ND, Elder GJ, Rajapakse CS, Holt SG, Baldock P, Robertson PL, Ebeling PR, Sorci OR, Masterson R
Source: Clin Transplant, 2018; 32(9): e13347, PMID: 29984421
GID: 4726; Last update: 16.07.2018

Research Studies (2018)

Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study.

OBJECTIVE: To investigate the associations between period-specific and cumulative fluoride (F) intakes from birth to age 17 years, and radial and tibial bone measures obtained using peripheral quantitative comp weiter...

Author: Oweis RR, Levy SM, Eichenberger-Gilmore JM, Warren JJ, Burns TL, Janz KF, Torner JC, Saha PK, Letuchy E
Source: Community Dent Oral Epidemiol, 2018; 46(6): 527-534, PMID: 29962091
GID: 4724; Last update: 09.07.2018

Research Studies (2018)

Assessment of bone quality in patients with diabetes mellitus.

Substantial evidence exists that diabetes mellitus is associated with an increased risk of osteoporotic fractures. Low bone strength as well as bone extrinsic factors are probably contributing to the increased weiter...

Author: Jiang N, Xia W
Source: Osteoporos Int, 2018; 29(8): 1721-1736, PMID: 29736760
GID: 4686; Last update: 22.05.2018

Research Studies (2018)

Validation of Peripheral Quantitative Computed Tomography-Derived Thigh Adipose Tissue Subcompartments in Young Girls Using a 3 T MRI Scanner.

The ability to assess skeletal muscle adipose tissue is important given the negative clinical implications associated with greater fat infiltration of the muscle. Computed tomography and magnetic resonance imag weiter...

Author: Blew RM, Lee VR, Bea JW, Hetherington-Rauth MC, Galons JP, Altbach MI, Lohman TG, Going SB
Source: J Clin Densitom, 2018; 21(4): 583-594, PMID: 29705002
GID: 4680; Last update: 07.05.2018

Fundamental Studies (2018)

The transgenerational effect of maternal and paternal F1 low birth weight on bone health of second and third generation offspring.

Low birth weight programs diseases in adulthood, including adverse bone health. These diseases can have intergenerational and transgenerational origins, whereby transmission to subsequent generations occurs vi weiter...

Author: Anevska K, Wark JD, Wlodek ME, Romano T
Source: J Dev Orig Health Dis, 2018; 314(): 161-170, PMID: 29631641
GID: 4663; Last update: 13.04.2018

Scientific Publications (2018)

Could bioelectric impedance spectroscopy (BIS) measured appendicular intracellular water serve as a lean mass measurement in sarcopenia definitions? A pilot study.

DXA lean mass measurement for sarcopenia diagnosis is not always possible. Bioelectric impedance spectroscopy (BIS), a portable technology, is a potential alternative to DXA-measured lean mass. This pilot study weiter...

Author: Siglinsky E, Buehring B, Krueger D, Binkley N, Yamada Y
Source: Osteoporos Int, 2018; 29(7): 1653-1657, PMID: 29574521
GID: 4662; Last update: 13.04.2018

Research Studies (2018)

Increases in IGF-1 after Anti-TNF-alpha Therapy are Associated with Bone and Muscle Accrual in Pediatric Crohn"s Disease.

Context: Low levels of IGF-1 in pediatric and adolescent Crohn"s Disease (CD) likely contribute to bone and muscle deficits. Objective: Assess changes in IGF-1 levels and associations with bone and muscle accru weiter...

Author: DeBoer MD, Lee AM, Herbert K, Long J, Thayu M, Griffin LM, Baldassano RN, Denson LA, Zemel BS, Denburg MR, Herskovitz R, Leonard MB
Source: J Clin Endocrinol Metab, 2018; 103(3): 936–945, PMID: 29329430
GID: 4613; Last update: 22.01.2018

Research Studies (2018)

The preventive effect of sensorimotor- and vibration exercises on the onset of Oxaliplatin- or vinca-alkaloid induced peripheral neuropathies - STOP.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients weiter...

Author: Streckmann F, Balke M, Lehmann HC, Rustler V, Koliamitra C, Elter T, Hallek M, Leitzmann M, Steinmetz T, Heinen P, Baumann FT, Bloch W
Source: BMC Cancer, 2018; 18(1): 62, PMID: 29316888
Keywords: Chemotherapy, Neuropathy
GID: 4580; Last update: 14.01.2018
More information: Original Article

Scientific Publications (2017)

Dietary Intake of Cadmium, Lead and Mercury and Its Association with Bone Health in Healthy Premenopausal Women.

The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to frac weiter...

Author: Lavado-Garcia JM, Puerto-Parejo LM, Roncero-Martin R, Moran JM, Pedrera-Zamorano JD, Aliaga IJ, Leal-Hernandez O, Canal-Macias ML
Source: Int J Environ Res Public Health, 2017; 14(12): 924-933, PMID: 29168740
Keywords: heavy metals; food; dietary intake; bone health; women’s health; premenopause; bone mineral density
GID: 4567; Last update: 28.11.2017

Research Studies (2017)

Long-term effects of maternal calcium supplementation on childhood growth differ between males and females in a population accustomed to a low calcium intake.

The importance of adequate calcium intakes for healthy growth and bone development has long been recognised. Recent evidence suggests that calcium supplementation may have sex-specific effects on bone growth in weiter...

Author: Ward KA, Jarjou L, Prentice A
Source: Bone, 2017; 103(): 31-38, PMID: 28583879
GID: 4556; Last update: 15.11.2017

Research Studies (2018)

Whole body vibration added to treatment as usual is effective in adolescents with depression: a partly randomized, three-armed clinical trial in inpatients.

There is growing evidence for the effectiveness of exercise in the treatment of adult major depression. With regard to adolescents, clinical trials are scarce. Due to the inherent symptoms of depression (lack o weiter...

Author: Wunram HL, Hamacher S, Hellmich M, Volk M, Janicke F, Reinhard F, Bloch W, Zimmer P, Graf C, Schonau E, Lehmkuhl G, Bender S, Fricke O
Source: Eur Child Adolesc Psychiatry, 2018; 27(5): 645-662, PMID: 29119301
Keywords: UniReha, Cologne Concept, Depression
GID: 4552; Last update: 14.11.2017

Research Studies (2017)

The Gambian Bone and Muscle Ageing Study: Baseline Data from a Prospective Observational African Sub-Saharan Study.

The Gambian Bone and Muscle Ageing Study is a prospective observational study investigating bone and muscle ageing in men and women from a poor, subsistence farming community of The Gambia, West Africa. Musculo weiter...

Author: Zengin A, Fulford AJ, Sawo Y, Jarjou LM, Schoenmakers I, Goldberg G, Prentice A, Ward KA
Source: Front Endocrinol (Lausanne), 2017; 8(): 219, PMID: 28912754
GID: 4531; Last update: 02.10.2017
More information: Original Article

Research Studies (2017)

Associations of Childhood and Adulthood Cognition with Bone Mineral Density in Later Adulthood: A Population-Based Longitudinal Study.

This study explores the association between cognitive ability in childhood and midlife and bone health outcomes in early old age; and the relationships of these bone measures with contemporaneous and subsequent weiter...

Author: Bendayan R, Kuh D, Cooper R, Muthuri S, Muniz-Terrera G, Adams J, Ward K, Richards M
Source: Front Aging Neurosci, 2017; 9(): 241, PMID: 28790912
GID: 4537; Last update: 02.10.2017
More information: Original Article

Research Studies (2017)

Comparison of the moulding ability of Plaster of Paris and polyester cast material in the healthy adult forearm.

OBJECTIVES: To quantify the moulding ability of Plaster of Paris and polyester cast materials as assessed by the novel use of peripheral quantitative computed tomography. METHODS: A prospective crossover study weiter...

Author: Bullen M, Kinealy J, Blanchard R, Rodda C, Pivonka P
Source: Injury, 2017; 48(11): 2586-2589, PMID: 28870625
GID: 4512; Last update: 11.09.2017

Research Studies (2017)

Mechanical basis of bone strength: influence of bone material, bone structure and muscle action.

This review summarises current understanding of how bone is sculpted through adaptive processes, designed to meet the mechanical challenges it faces in everyday life and athletic pursuits, serving as an update weiter...

Author: Hart NH, Nimphius S, Rantalainen T, Ireland A, Siafarikas A, Newton RU
Source: J Musculoskelet Neuronal Interact, 2017; 17(3): 114-139, PMID: 28860414
Keywords: Bone Geometry, Mechanostat, Bone adaptation
GID: 4503; Last update: 06.09.2017

Research Studies (2017)

The Vietnam Osteoporosis Study: Rationale and design

Objectives: Osteoporosis and fracture impose a significant health care burden on the contemporary populations in developing countries. The Vietnam Osteoporosis Study (VOS) sought to assess the burden of osteopo weiter...

Author: Lan T. Ho-Pham, Tuan V. Nguyen
Source: Osteoporosis and Sarcopenia, 2017; 3(2): 90-97
GID: 4485; Last update: 31.08.2017
More information: Original Article

Research Studies (2017)

Please Don"t Move-Evaluating Motion Artifact From Peripheral Quantitative Computed Tomography Scans Using Textural Features.

Most imaging methods, including peripheral quantitative computed tomography (pQCT), are susceptible to motion artifacts particularly in fidgety pediatric populations. Methods currently used to address motion ar weiter...

Author: Rantalainen T, Chivers P, Beck BR, Robertson S, Hart NH, Nimphius S, Weeks BK, McIntyre F, Hands B, Siafarikas A
Source: J Clin Densitom S1094-6950(17), 2017; S1094-6950(17): 30022-7, PMID: 28801168
GID: 4484; Last update: 31.08.2017

Research Studies (2017)

Musculoskeletal health in newly diagnosed children with Crohn"s disease.

We evaluated the impact of Crohn"s disease on muscle and bone strength, mass, density, and geometry in children with newly diagnosed CD and found profound muscle and bone deficits; nevertheless, the prevalence weiter...

Author: Ward LM, Ma J, Rauch F, Benchimol EI, Hay J, Leonard MB, Matzinger MA, Shenouda N, Lentle B, Cosgrove H, Scharke M, Konji VN, Mack DR
Source: Osteoporos Int, 2017; 28(): 3169–3177, PMID: 28791436
GID: 4480; Last update: 14.08.2017

Research Studies (2017)

Muscle abnormalities in osteogenesis imperfecta.

Osteogenesis imperfecta (OI) is mainly characterized by bone fragility but muscle abnormalities have been reported both in OI mouse models and in children with OI. Muscle mass is decreased in OI, even when shor weiter...

Author: Veilleux LN, Trejo P, Rauch F
Source: J Musculoskelet Neuronal Interact, 2017; 17(2): 1-7, PMID: 28574406
Keywords: pQCT Muscle
GID: 4474; Last update: 12.07.2017
More information: Original Article

Research Studies (2017)

Muscle power in children, youth and young adults who acquired HIV perinatally.

OBJECTIVES: To compare muscle power between youth who acquired HIV perinatally and HIV unexposed uninfected (HUU) youth. METHODS: We assessed muscle power (relative to body mass, Pmax/mass), muscle force normal weiter...

Author: Macdonald EtaMu, Nettlefold L, Maan EJ, Cote H, Alimenti A
Source: J Musculoskelet Neuronal Interact, 2017; 17(2): 27-37, PMID: 28574409
GID: 4455; Last update: 06.06.2017
More information: Original Article

Research Studies (2017)

Effects of vibration training in reducing risk of slip-related falls among young adults with obesity.

This study examined the effects of controlled whole-body vibration training on reducing risk of slip-related falls in people with obesity. Twenty-three young adults with obesity were randomly assigned into eith weiter...

Author: Yang F, Munoz J, Han LZ, Yang F
Source: J Biomech, 2017; 57(): 87-93, PMID: 28431747
Keywords: Obesity, Fall-Risk, Muscke Funktion, Msucel Force
#GRFS140
GID: 4433; Last update: 02.05.2017

Research Studies (2017)

Associations of muscle force, power, cross-sectional muscle area and bone geometry in older UK men.

BACKGROUND: Ageing is associated with sarcopenia, osteoporosis, and increased fall risk, all of which contribute to increased fracture risk. Mechanically, bone strength adapts in response to forces created by m weiter...

Author: Zengin A, Pye SR, Cook MJ, Adams JE, Rawer R, Wu FCW, O"Neill TW, Ward KA
Source: J Cachexia Sarcopenia Muscle, 2017; doi:10.1002/jcsm.12198: , PMID: 28474432
GID: 4425; Last update: 24.04.2017
More information: Original Article

Research Studies (2017)

Static postural control in youth with osteogenesis imperfecta type I

Objective: To assess static postural control in eyes-open and eyes-closed conditions in 4 individuals with osteogenesis imperfecta (OI) type I as compared to typically developing (TD) 5 individuals. The secon weiter...

Author: Pouliot-Laforte A, LemayM , Rauch F, Veilleux LN
Source: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2017;
Keywords: Posturography
GID: 4424; Last update: 24.04.2017

Research Studies (2015)

Measuring Muscle and Fat with Peripheral Quantitative Computed Tomography: Precision, Annual Changes, Monitoring Intervals, and Associations with Fall Status in Older Adults

Objectives: The overall aim of this thesis was to investigate the precision error, annual changes, and monitoring time intervals of muscle and fat outcomes measured by peripheral quantitative computed tomograp weiter...

Author: Andrew William Frank-Wilson
Source: Thesis, 2015;
GID: 4411; Last update: 11.04.2017

Research Studies (2017)

Cardiovascular calcification and subcortical bone demineralization in hypertension.

The present study investigated cardiovascular calcification, peripheral bone mineral density (BMD), and lab indices in hypertensive patients aged 55-74 years without severe kidney dysfunction. Cardiovascular c weiter...

Author: Cirillo C, Bilancio G, Natale F, Concilio C, Russo MG, Calabro P, Cirillo M
Source: Hypertens Res, 2017; 40(9): 825-830, PMID: 28381870
GID: 4408; Last update: 10.04.2017

Scientific Publications (2018)

Measuring Marrow Density and Area Using Peripheral Quantitative Computed Tomography at the Tibia: Precision in Young and Older Adults and Individuals With Spinal Cord Injury.

The objective of this study was to compare the test-retest precision error for peripheral quantitative computed tomography (pQCT)-derived marrow density and marrow area segmentation at the tibia using 3 softwar weiter...

Author: Gibbs JC, Brown ZM, Wong AK, Craven BC, Adachi JD, Giangregorio LM
Source: J Clin Densitom, 2018; 21(2): 269-280, PMID: 28359675
GID: 4409; Last update: 10.04.2017

Research Studies (2017)

Lower Jump Power Rather Than Muscle Mass Itself is Associated with Vertebral Fracture in Community-Dwelling Elderly Korean Women.

Sarcopenia is considered to be a risk factor for osteoporotic fracture, which is a major health problem in elderly women. In this study, we aimed to investigate the association of sarcopenia, with regard to mu weiter...

Author: Lee EY, Lee SJ, Kim KM, Seo DH, Lee SW, Choi HS, Kim HC, Youm Y, Kim CO, Rhee Y
Source: Calcif Tissue Int, 2017; 100(6): 585-594, PMID: 28275826
GID: 4405; Last update: 05.04.2017

Research Studies (2006)

Effekte eines niedrigfrequenten Ganzkörpervibrationstrainings auf dem Galileo 2000

Zusammenfassung: Dem Ganzkörpertraining wird der präventive und rehabilitative Nutzen nachgesagt, die Mineralisierung der Knochen zu fördern und darüber hinaus einer allgemeinen Muskeldegeneration entgegen weiter...

Author: Huber G, Weiss K, Eckert K
Source: B & G, 2006; 22(2): 52-57
GID: 4395; Last update: 01.04.2017

Research Studies (2017)

What"s the secret behind the benefits of whole-body vibration training in patients with COPD? A randomized, controlled trial.

BACKGROUND: Several studies have shown that whole-body vibration training (WBVT) improves exercise capacity in patients with severe COPD. The aim of this study was to investigate the determinants of improved e weiter...

Author: Gloeckl R, Jarosch I, Bengsch U, Claus M, Schneeberger T, Andrianopoulos V, Christle JW, Hitzl W, Kenn K
Source: Respir Med, 2017; 126: 17-24, PMID: 28427544
Keywords: COPD, Muslce Power, Balance, Mechanography
#GRFS144
GID: 4386; Last update: 20.03.2017

Research Studies (2018)

Peripheral Quantitative Computed Tomography (pQCT) Measures Contribute to the Understanding of Bone Fragility in Older Patients With Low-trauma Fracture.

Dual-energy X-ray absorptiometry (DXA) as currently used has limitations in identifying patients with osteoporosis and predicting occurrence of fracture. We aimed to express peripheral quantitative computed to weiter...

Author: Jiang H, Yates CJ, Gorelik A, Kale A, Song Q, Wark JD
Source: J Clin Densitom, 2018; 21(1): 140-147, PMID: 28285742
GID: 4385; Last update: 20.03.2017

Research Studies (2017)

Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9-13 Years.

IGF-I is a pivotal hormone in pediatric musculoskeletal development. Though recent data suggest that the role of IGF-I in total body lean mass and total body bone mass accrual may be compromised in children wit weiter...

Author: Kindler JM, Pollock NK, Laing EM, Oshri A, Jenkins NT, Isales CM, Hamrick MW, Ding KH, Hausman DB, McCabe GP, Martin BR, Hill Gallant KM, Warden SJ, Weaver CM, Peacock M, Lewis RD
Source: J Bone Miner Res, 2017; 32(7): 1537-1545, PMID: 28300329
GID: 4384; Last update: 20.03.2017

Research Studies (2017)

Whole-body vibration training as a workplace-based sports activity for employees with chronic low-back pain.

INTRODUCTION: The goal of this randomized and controlled study is to examine whether whole-body vibration (WBV) training is able to reduce back pain and physical disability in seated working office employees wi weiter...

Author: Kaeding TS, Karch A, Schwarz R, Flor T, Wittke TC, Kuck M, Boselt G, Tegtbur U, Stein L
Source: Scand J Med Sci Sports, 2017; 27(12): 2027-2039, PMID: 28185300
Keywords: Back-Pain, Workplace, Leonardo Balance
#GRFS98
GID: 4369; Last update: 17.02.2017

Scientific Publications (2011)

Gait speed and survival in older adults.

CONTEXT: Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival. Physical performance measures, such as gait speed, mi weiter...

Author: Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, Brach J, Chandler J, Cawthon P, Connor EB, Nevitt M, Visser M, Kritchevsky S, Badinelli S, Harris T, Newman AB, Cauley J, Ferrucci L, Guralnik J
Source: JAMA, 2011; 305(1): 50-8, PMID: 21205966
Keywords: Gait Speed
GID: 4364; Last update: 12.02.2017
More information: Original Article

Research Studies (2017)

A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises.

BACKGROUND: Chemotherapy-induced polyneuropathy (CIPN) is a common toxicity after chemotherapy, immunomodulatory drugs or proteasome inhibitors, which is difficult to treat and may also have impact on quality o weiter...

Author: Schonsteiner SS, Bauder Missbach H, Benner A, Mack S, Hamel T, Orth M, Landwehrmeyer B, Sussmuth SD, Geitner C, Mayer-Steinacker R, Riester A, Prokein A, Erhardt E, Kunecki J, Eisenschink AM, Rawer R, Dohner H, Kirchner E, Schlenk RF
Source: Exp Hematol Oncol, 2017; 6: 5, PMID: 28194306
Keywords: Neuropathy
#GRFS36
GID: 4363; Last update: 08.02.2017
More information: Original Article

Research Studies (2017)

Oscillatory whole-body vibration improves exercise capacity and physical performance in pulmonary arterial hypertension: a randomised clinical study.

OBJECTIVE: In patients with pulmonary arterial hypertension (PAH), supportive therapies may be beneficial in addition to targeted medical treatment. Here, we evaluated the effectiveness and safety of oscillator weiter...

Author: Gerhardt F, Dumitrescu D, Gartner C, Beccard R, Viethen T, Kramer T, Baldus S, Hellmich M, Schonau E, Rosenkranz S
Source: Heart, 2017; 103(8): 592-598, PMID: 28100544
Keywords: PAH, 6MWD, HRQoL
#GRFS80
GID: 4351; Last update: 20.01.2017
More information: Original Article

Research Studies (2016)

A controlled trial comparing one-year biochemical bone metabolism outcome in postmenopausal frail osteopenic women under weekly alendronate treatment, with or without whole-body vibration intervention

Purpose: The influence of regular exercise on bone properties is not well defined. Frail subjects have limitations to perform exercise with skeletal impact. This study aims to analyze whole-bone vibration tre weiter...

Author: Ricardo Capiglioni , Claudia Gomez Acotto, Alicia Marino, Mar.a Georgina Muntaabski, Victor Montangero, Luciana D´Alessio, Emilio Jose Antonio Roldan
Source: Journal of Frailty, Sarcopenia and Falls, 2016; 1(3): 29-37
Keywords: Bone biochemical markers, Drinkable alendronate, Osteopenia, Osteoporosis, Peripheral quantitative computerized tomography, Whole-Body-Vibration
GID: 4352; Last update: 20.01.2017

Research Studies (2016)

Low-energy trauma-induced intercondylar femoral fracture.

We present a 44-year-old female patient with recurrent fragility fractures including an intercondylar femoral fracture and with normal planar bone densitometry. Diagnosis of hypophosphatasia was suggested by lo weiter...

Author: Aeby M, Wyss T, Mentrup B, Kunstmann E, Jakob F, Aeberli D
Source: Clin Cases Miner Bone Metab, 2016; 13(2): 151-153, PMID: 27920814
Keywords: hypophosphatasia; fragility fracture; DXA; intercondylar; pQCT
GID: 4344; Last update: 11.01.2017

Research Studies (2016)

Lower insulin sensitivity is related to lower relative muscle cross-sectional area, lower muscle density and lower handgrip force in young and middle aged non-diabetic men.

OBJECTIVES: This study investigated whether an association between insulin resistance (IR) and muscle parameters is appreciable in young healthy men, independent of obesity. Furthermore, markers of muscle metab weiter...

Author: Gysel T, Tonoli C, Pardaens S, Cambier D, Kaufman JM, Zmierczak HG, Goemaere S, Lapauw B, Calders P
Source: J Musculoskelet Neuronal Interact, 2016; 16(4): 302-309, PMID: 27973382
Keywords: Insulin Resistance, Muscle Cross-sectional Area, Handgrip Strength, Estradiol
GID: 4347; Last update: 11.01.2017

Research Studies (2017)

Effect of Exercise and Antidepressants on Skeletal Outcomes in Adolescent Girls With Anorexia Nervosa.

PURPOSE: We examined the relationships between malnutrition, lifestyle factors, and bone health in anorexia nervosa (AN) via dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomograph weiter...

Author: DiVasta AD, Feldman HA, O"Donnell JM, Long J, Leonard MB, Gordon CM
Source: J Adolesc Health, 2017; 60(2): 229-232, PMID: 27939877
Keywords: Anorexia nervosa; Malnutrition; Peripheral quantitative computed tomography; DXA; Exercise; Antidepressant
GID: 4342; Last update: 11.01.2017

Research Studies (2017)

Habitual levels of higher, but not medium or low, impact physical activity are positively related to lower limb bone strength in older women: findings from a population-based study using accelerometers to classify impact magnitude.

This study assessed the effect of accelerometry-measured higher impacts resulting from habitual weight-bearing activity on lower limb bone strength in older women. Despite higher impacts being experienced rarel weiter...

Author: Hannam K, Deere KC, Hartley A, Al-Sari UA, Clark EM, Fraser WD, Tobias JH
Source: Osteoporos Int, 2017; 28(10): 2813-2822, PMID: 27966105
Keywords: G-force . Hip BMD . Tibial pQCT
GID: 4341; Last update: 11.01.2017

Research Studies (2016)

Reference data for jumping mechanography in Canadian children, adolescents and young adults.

OBJECTIVES: To provide age- and sex-specific reference data for mechanography-derived parameters of muscle function in Canadian children and youth using the single two-legged jump (S2LJ) with hands-on-waist. ME weiter...

Author: Gabel L, Macdonald HM, Nettlefold L, Race D, McKay HA
Source: J Musculoskelet Neuronal Interact, 2016; 16(4): 283-295, PMID: 27973380
Keywords: SQ, CMJ
GID: 4311; Last update: 21.12.2016
More information: Original Article

Research Studies (2016)

Distal fibula fracture fixation: Biomechanical evaluation of three different fixation implants.

BACKGROUND: The goal of this study was to evaluate the biomechanical performance of three distal fibula fracture fixation implants in a matched pair cadaveric fibula model: (1) a 5-hole compression plate with weiter...

Author: Knutsen AR, Sangiorgio SN, Liu C, Zhou S, Warganich T, Fleming J, Harris TG, Ebramzadeh E
Source: Foot Ankle Surg, 2016; 22(4): 278-285, PMID: 27810029
GID: 4305; Last update: 29.11.2016

Research Studies (2016)

Bone turnover predicts change in volumetric bone density and bone geometry at the radius in men.

Peripheral quantitative computed tomography scans of the distal and midshaft radius were performed in 514 European men aged 40-79 years at baseline and a median of 4.3 years later. Age-related changes in volume weiter...

Author: Pye SR, Ward KA, Cook MJ, Laurent MR, Gielen E, Borghs H, Adams JE, Boonen S, Vanderschueren D, Wu FC, O"Neill TW
Source: Osteoporos Int, 2016; 28(3): 935-944, PMID: 27815569
GID: 4304; Last update: 29.11.2016
More information: Original Article

Research Studies (2017)

Geometry reconstruction method for patient-specific finite element models for the assessment of tibia fracture risk in osteogenesis imperfecta.

Lower limb deformation in children with osteogenesis imperfecta (OI) impairs ambulation and may lead to fracture. Corrective surgery is based on empirical assessment criteria. The objective was to develop a rec weiter...

Author: Caouette C, Ikin N, Villemure I, Arnoux PJ, Rauch F, Aubin CE
Source: Med Biol Eng Comput, 2017; 55(4): 549-560, PMID: 27314506
GID: 4189; Last update: 27.06.2016

Research Studies (2016)

Muscle histology changes after short term vibration training in healthy controls

In search for additional counter measures of muscle atrophy vibration exercise training may have substantial effort for patients with neuromuscular disorders. To cover safety aspects and obtain muscle morpholog weiter...

Author: Schoser B
Source: Acta Myol, 2016; 34(2-3): 133-8, PMID: 27199541
Keywords: Muscle Histology, Muscle function, muscle power, muscle fiber
#GRFS29
GID: 4195; Last update: 27.06.2016
More information: Original Article

Research Studies (2015)

Greater tibial bone strength in male tennis players than controls in the absence of greater muscle output

Background/Objective: The greatest forces experienced by bones result from muscular contractions muscles produce most force in high-velocity eccentric contractions. Bouncing movements, e.g., sprinting or hoppin weiter...

Author: Alex Ireland, Hans Degens, Bergita Ganse, Thomas Mark Maden-Wilkinson , Desiree Christin Wilks, Jörn Rittweger
Source: Journal of Orthopaedic Translation, 2015; 3(3): 142–151
GID: 4149; Last update: 19.04.2016
More information: Original Article

Research Studies (2016)

Human Musculoskeletal Models of Disuse

According to Frost’s mechanostat theory when the bone receives strains of about 800 to 1600 micro-strain retains its strength; increased strains promote formation (remodeling) up to a fracture point, and whe weiter...

Author: Dionyssiotis Y., Kapsokoulou A., Samlidi E., Iatridou G.
Source: JFSF, Journal of Frailty, Sarcopenia and Falls, 2016; 1(1): 4-7
GID: 4133; Last update: 11.04.2016
More information: Original Article

Research Studies (2016)

Effects of whole-body vibration training on physical function, bone and muscle mass in adolescents and young adults with cerebral palsy.

We performed a clinical trial on the effects of whole-body vibration training (WBVT) on muscle function and bone health of adolescents and young adults with cerebral palsy. Forty participants (11.3-20.8 years) weiter...

Author: Gusso S, Munns CF, Colle P, Derraik JG, Biggs JB, Cutfield WS, Hofman PL
Source: Sci Rep, 2016; 3;6: 22518, PMID: 26936535
Keywords: Galileo CP,Walking Distance, Chair Rising Test,improved muscle function
#GRFS13
GID: 4116; Last update: 09.03.2016
More information: Original Article

Research Studies (2005)

From mechanostat theory to development of the "Functional Muscle-Bone-Unit".

Bone densitometric data are often difficult to interpret in children and adolescents because of large inter- and intraindividual variations in bone size. Here, we propose a functional approach to bone densitom weiter...

Author: Schoenau E
Source: J Musculoskelet Neuronal Interact, 2005; 5(3): 232-8, PMID: 16172514
GID: 4107; Last update: 17.02.2016
More information: Original Article

Research Studies (2005)

The effect of exercise and nutrition on the mechanostat.

In this review, we discuss the effect of increased and decreased loading and nutrition deficiency on muscle and bone mass and strength (and bone length and architecture) independently and combined. Both exercis weiter...

Author: Bass SL, Eser P, Daly R
Source: J Musculoskelet Neuronal Interact, 2005; 5(3): 239-54, PMID: 16172515
GID: 4108; Last update: 17.02.2016
More information: Original Article

Research Studies (2016)

Acute effects of unilateral whole body vibration training on single leg vertical jump height and symmetry in healthy men.

[Purpose] The aim of the present study was to investigate the acute effects of unilateral whole body vibration training on height and symmetry of the single leg vertical jump in healthy men. [Subjects] Thirty m weiter...

Author: Shin S, Lee K, Song C
Source: J Phys Ther Sci, 2016; 27(12): 3923-8, PMID: 26834381
Keywords: Single leg vertical jump, Symmetry, Whole body vibration
#GRFS77
GID: 4076; Last update: 16.02.2016

Research Studies (2015)

Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters.

Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We weiter...

Author: Hoff P, Belavy DL, Huscher D, Lang A, Hahne M, Kuhlmey AK, Maschmeyer P, Armbrecht G, Fitzner R, Perschel FH, Gaber T, Burmester GR, Straub RH, Felsenberg D, Buttgereit F
Source: Cell Mol Immunol, 2015; 12(4): 483-92, PMID: 25382740
Keywords: Galileo Space, Immune System
#GRFS90
GID: 4070; Last update: 29.01.2016
More information: Original Article

Research Studies (2016)

Association of Jumping Mechanography-Derived Indices of Muscle Function with Tibial Cortical Bone Geometry.

Jumping mechanography has been developed to estimate maximum voluntary muscle forces. This study assessed associations of jumping mechanography-derived force and power measurements with tibial cortical bone geo weiter...

Author: Verroken C, Zmierczak HG, Goemaere S, Kaufman JM, Lapauw B
Source: Calcif Tissue Int, 2016; 98(): 446–455, PMID: 26671019
GID: 4043; Last update: 15.01.2016

Research Studies (2015)

Effect of age and sex on jumping mechanography and other measures of muscle mass and function.

OBJECTIVES: Sarcopenia increases falls and fracture risk. Sarcopenia clinical trials require robust quantitative tools to evaluate muscle function; jumping mechanography (JM) is likely one such tool. However, U weiter...

Author: Siglinsky E, Krueger D, Ward RE, Caserotti P, Strotmeyer ES, Harris TB, Binkley N, Buehring B
Source: J Musculoskelet Neuronal Interact, 2015; 15(4): 301-8, PMID: 26636275
GID: 4042; Last update: 10.12.2015
More information: Original Article

Research Studies (2015)

Greater association of peak neuromuscular performance with cortical bone geometry, bone mass and bone strength than bone density: A study in 417 older women.

BACKGROUND: We evaluated which aspects of neuromuscular performance are associated with bone mass, density, strength and geometry. METHODS: 417 women aged 60-94years were examined. Countermovement jump, sit-to- weiter...

Author: Belavy DL, Armbrecht G, Blenk T, Bock O, Borst H, Kocakaya E, Luhn F, Rantalainen T, Rawer R, Tomasius F, Willnecker J, Felsenberg D
Source: Bone, 2015; 83: 119-126, PMID: 26541093
GID: 4028; Last update: 10.11.2015

Research Studies (2015)

Reliability of parameters during stair ascent measured with Leonardo Mechanograph((R)) Stair A in healthy subjects.

OBJECTIVES: Stair climbing (SC) as daily activity is assessed with different SC-tests, but none directly measures ground reaction force over several steps. The Leonardo Mechanograph Stair A has five steps and f weiter...

Author: Saxer S, Speich R, Toigo M, Mueller SM, Ulrich Somaini S
Source: J Musculoskelet Neuronal Interact, 2015; 15(3): 257-63, PMID: 26350944
Keywords: Leonardo SC, Leonardo Mechanography Stair
GID: 3968; Last update: 10.09.2015
More information: Original Article

Research Studies (2015)

Mechanography performance tests and their association with sarcopenia, falls and impairment in the activities of daily living - a pilot cross-sectional study in 293 older adults.

OBJECTIVES: Muscle mass and muscle power considerably decline with aging. The aim of the present study was to determine the association between muscular function using mechanography and sarcopenia, falls and im weiter...

Author: Dietzel R, Felsenberg D, Armbrecht G
Source: J Musculoskelet Neuronal Interact, 2015; 15(3): 249-56, PMID: 26350943
Keywords: Leonardo, Sarcopenia, Performance
GID: 3967; Last update: 10.09.2015
More information: Original Article

Research Studies (2013)

Bone density and neuromuscular function in older competitive athletes depend on running distance.

Individuals who are involved in explosive sport types, such as 100-m sprints and long jump, have greater bone density, leg muscle size, jumping height and grip strength than individuals involved in long-distan weiter...

Author: Gast U, Belavy DL, Armbrecht G, Kusy K, Lexy H, Rawer R, Rittweger J, Winwood K, Zielinski J, Felsenberg D
Source: Osteoporos Int, 2013; 24(7): 2033-42, PMID: 23242430
GID: 3954; Last update: 23.07.2015

Research Studies (2015)

Reduced bone strength and muscle force in women 27 years after anorexia nervosa.

CONTEXT: A substantial body of research findings indicate that muscle mass and bone mass are reduced in populations of anorexic females, even in such populations, whose anorexia nervosa had been in remission fo weiter...

Author: Mueller SM, Immoos M, Anliker E, Drobnjak S, Boutellier U, Toigo M
Source: J Clin Endocrinol Metab, 2015; (): jc20151011, PMID: 26086327
GID: 3929; Last update: 25.06.2015

Research Studies (2015)

Deficits in bone density and structure in children and young adults following Fontan palliation.

BACKGROUND: Survival of patients with congenital heart disease has improved such that there are now more adults than children living with these conditions. Complex single ventricle congenital heart disease req weiter...

Author: Avitabile CM, Goldberg DJ, Zemel BS, Brodsky JL, Dodds K, Hayden-Rush C, Whitehead KK, Goldmuntz E, Rychik J, Leonard MB
Source: Bone, 2015; 77(): 12-6, PMID: 25882907
GID: 3921; Last update: 17.06.2015

Research Studies (2015)

Re-examining the surfaces of bone in boys and girls during adolescent growth: a 12-year mixed longitudinal pQCT study.

We revisit Stanley Garn"s theory related to sex differences in endocortical and periosteal apposition during adolescence using a 12-year mixed longitudinal study design. We used peripheral quantitative computed weiter...

Author: Gabel L, Nettlefold L, Brasher PM, Moore S, Ahamed Y, Macdonald HM, McKay HA
Source: J Bone Miner Res, 2015; 30(12): 2158-67, PMID: 26058373
Keywords: pQCT; BONE ACCRUAL; BONE STRENGTH; PEAK HEIGHT VELOCITY; GROWTH
GID: 3908; Last update: 17.06.2015

Research Studies (2015)

Physical activity in youth with osteogenesis imperfecta type I.

INTRODUCTION: Individuals with Osteogenesis Imperfecta (OI) type I often show muscular weakness. However, it is unclear whether muscular weakness is a consequence of physical inactivity or a result of the disea weiter...

Author: Pouliot-Laforte A, Veilleux LN, Rauch F, Lemay M
Source: J Musculoskelet Neuronal Interact, 2015; 15(2): 171-6, PMID: 26032209
GID: 3924; Last update: 17.06.2015
More information: Original Article

Research Studies (2015)

The functional muscle-bone unit in patients with osteogenesis imperfecta type I.

CONTEXT: Osteogenesis imperfecta (OI) type I is a heritable bone fragility disorder that is caused by mutations affecting collagen type I. We recently showed that patients with OI type I frequently have muscle weiter...

Author: Veilleux LN, Pouliot-Laforte A, Lemay M, Cheung MS, Glorieux FH, Rauch F
Source: Bone, 2015; 79(): 52-57, PMID: 26004918
GID: 3925; Last update: 17.06.2015

Research Studies (2015)

Adolescence physical activity is associated with higher tibial pQCT bone values in adulthood after 28-years of follow-up - The Cardiovascular Risk in Young Finns Study.

High peak bone mass and strong bone phenotype are known to be partly explained by physical activity during growth but there are few prospective studies on this topic. In this 28-year follow-up of Cardiovascular weiter...

Author: Tolonen S, Sievanen H, Mikkila V, Telama R, Oikonen M, Laaksonen M, Viikari J, Kahonen M, Raitakari OT
Source: Bone, 2015; 75(): 77-83, PMID: 25697084
GID: 3853; Last update: 08.04.2015

Research Studies (2015)

Alterations in bone mineral density and lower extremity lean mass after hip arthroscopy in a professional female Ironman triathlete: a case study.

INTRODUCTION: Femoroacetabular impingement is a pathomechanical condition of the hip, which is often treated through arthroscopic techniques. The ensuing immobilization period is associated with decreases in m weiter...

Author: Mueller SM, Braendli S, Toigo M
Source: Springerplus, 2015; 4(): 70, PMID: 25713762
GID: 3851; Last update: 08.04.2015
More information: Original Article

Research Studies (2015)

Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults. A pQCT study.

To compare the independent influence of mechanical and non-mechanical factors on bone features, multiple regression analyses were performed between pQCT indicators of radius and tibia bone mass, mineralization weiter...

Author: Reina P, Cointry GR, Nocciolino L, Feldman S, Ferretti JL, Rittweger J, Capozza RF
Source: J Musculoskelet Neuronal Interact, 2015; 15(1): 10-22, PMID: 25730648
GID: 3850; Last update: 08.04.2015
More information: Original Article

Fundamental Studies (2015)

Longitudinal changes in lean mass predict pQCT measures of tibial geometry and mineralisation at 6-7years.

BACKGROUND: Studies in childhood suggest that both body composition and early postnatal growth are associated with bone mineral density (BMD). However, little is known of the relationships between longitudinal weiter...

Author: Moon RJ, Cole ZA, Crozier SR, Curtis EM, Davies JH, Gregson CL, Robinson SM, Dennison EM, Godfrey KM, Inskip HM, Cooper C, Harvey NC
Source: Bone, 2015; 75(): 105-10, PMID: 25703480
GID: 3852; Last update: 08.04.2015

Research Studies (2015)

Measurement of muscle and fat in postmenopausal women: precision of previously reported pQCT imaging methods.

Peripheral quantitative computed tomography (pQCT) imaging has been used to quantify muscle area and density as well as intermuscular adipose tissue (IMAT) and subcutaneous adipose tissue (SAT) area in the lowe weiter...

Author: Frank-Wilson AW, Johnston JD, Olszynski WP, Kontulainen SA
Source: Bone, 2015; 75(): 49-54, PMID: 25659205
GID: 3857; Last update: 08.04.2015

Research Studies (2015)

Lower-extremity muscle atrophy and fat infiltration after chronic spinal cord injury.

BACKGROUND: Atrophy and fatty-infiltration of lower-extremity muscle after spinal cord injury (SCI) predisposes individuals to metabolic disease and related mortality. OBJECTIVES: To determine the magnitude of weiter...

Author: Moore CD, Craven BC, Thabane L, Laing AC, Frank-Wilson AW, Kontulainen SA, Papaioannou A, Adachi JD, Giangregorio LM
Source: J Musculoskelet Neuronal Interact, 2015; 15(1): 32-41, PMID: 25730650
GID: 3859; Last update: 08.04.2015
More information: Original Article

Research Studies (2015)

Effects of five days of bed rest with intermittent centrifugation on neurovestibular function.

OBJECTIVES: We tested whether intermittent short-radius centrifugation was effective for mitigating alteration in balance and gait following bed rest. METHODS: Ten male subjects were exposed to 5 days of 6 degr weiter...

Author: Clement G, Bareille MP, Goel R, Linnarsson D, Mulder E, Paloski WH, Rittweger J, Wuyts FL, Zange J
Source: J Musculoskelet Neuronal Interact, 2015; 15(1): 60-8, PMID: 25730653
GID: 3860; Last update: 08.04.2015
More information: Original Article

Research Studies (2015)

The muscle-bone interaction in Turner syndrome.

OBJECTIVES: Turner syndrome (TS) is associated with an increased fracture rate due to reduced bone strength, which is mainly determined by skeletal muscle force. This study aimed to assess the muscle force-bone weiter...

Author: Soucek O, Matyskova J, Anliker E, Toigo M, Hlavka Z, Lebl J, Sumnik Z
Source: Bone, 2015; 74C(): 160-165, PMID: 25659206
GID: 3772; Last update: 16.02.2015

Research Studies (2015)

Reproducibility of jumping mechanography and traditional measures of physical and muscle function in older adults.

Improved approaches to assess functional change over time are needed to optimally reduce fall/fracture risk; jumping mechanography (JM) may be one such methodology. In this study, JM parameters were more reprod weiter...

Author: Buehring B, Krueger D, Fidler E, Gangnon R, Heiderscheit B, Binkley N
Source: Osteoporos Int, 2015; 26(2): 819-25, PMID: 25488806
GID: 3750; Last update: 10.02.2015

Research Studies (2014)

Physiological alterations after a marathon in the first 90-year-old male finisher: case study.

INTRODUCTION: Endurance performance decreases during ageing due to alterations in physiological characteristics, energy stores, and psychological factors. To investigate alterations in physiological characteris weiter...

Author: Mueller SM, Knechtle B, Knechtle P, Toigo M
Source: Springerplus, 2014; 3(): 608, PMID: 25392780
GID: 3662; Last update: 24.11.2014
More information: Original Article

Research Studies (2015)

Neuromuscular training based on whole body vibration in children with spina bifida: a retrospective analysis of a new physiotherapy treatment program.

INTRODUCTION: Spina bifida is the most common congenital cause of spinal cord lesions resulting in paralysis and secondary conditions like osteoporosis due to immobilization. Physiotherapy is performed for opt weiter...

Author: Stark C, Hoyer-Kuhn HK, Semler O, Hoebing L, Duran I, Cremer R, Schoenau E
Source: Childs Nerv Syst, 2015; 31(2): 301-9, PMID: 25370032
Keywords: Spina Bifida, Cologne Concept, Auf die Beine, Kölner Konzept, Kontrakturen, Contractures
#GRFS15, #GRFS148
GID: 3658; Last update: 24.11.2014

Research Studies (2014)

Feasibility, compliance, and efficacy of a randomized controlled trial using vibration in pre-pubertal children.

OBJECTIVE: Interventions utilizing vibration may increase bone mass and size which may reduce forearm fractures in children. This randomized controlled pilot trial tested the feasibility, compliance and effica weiter...

Author: Binkley TL, Parupsky EC, Kleinsasser BA, Weidauer LA, Specker BL
Source: J Musculoskelet Neuronal Interact, 2014; 14(3): 294-302, PMID: 25198224
Keywords: BMC, BMD, High-intensity Vibration, Low-intensity Vibration, DXA, pQCT
GID: 3632; Last update: 16.09.2014

Research Studies (2014)

Whole Body Vibration Exercise Protocol versus a Standard Exercise Protocol after ACL Reconstruction: A Clinical Randomized Controlled Trial with Short Term Follow-Up.

The suitability and effectiveness of whole body vibration (WBV) exercise in rehabilitation after injury of the anterior cruciate ligament (ACL) was studied using a specially designed WBV protocol. We wanted to weiter...

Author: Berschin G, Sommer B, Behrens A, Sommer HM
Source: J Sports Sci Med, 2014; 13(3): 580-9, PMID: 25177185
Keywords: Knee injury, anterior cruciate ligament, rehabilitation, exercise protocol, neuromuscular performance.
#GRFS85
GID: 3623; Last update: 16.09.2014

Research Studies (2014)

Muscle anatomy and dynamic muscle function in osteogenesis imperfecta type I.

CONTEXT: Results of previous studies suggested that children and adolescents with osteogenesis imperfecta (OI) type I have a muscle force deficit. However, muscle function has only been assessed by static isom weiter...

Author: Veilleux LN, Lemay M, Pouliot-Laforte A, Cheung MS, Glorieux FH, Rauch F
Source: J Clin Endocrinol Metab, 2014; 99(2): E356-62, PMID: 24248189
GID: 3584; Last update: 28.08.2014

Research Studies (2014)

Jump power and force have distinct associations with cortical bone parameters: findings from a population enriched by individuals with high bone mass.

CONTEXT: Little is known of the relationships between muscle function and bone, based on the recently developed technique of jumping mechanography. OBJECTIVE: Our objective was to determine associations between weiter...

Author: Hardcastle SA, Gregson CL, Rittweger J, Crabtree N, Ward K, Tobias JH
Source: J Clin Endocrinol Metab, 2014; 99(1): 266-75, PMID: 24203064
GID: 3515; Last update: 20.03.2014

Research Studies (2014)

Whole body vibration training - improving balance control and muscle endurance.

Exercise combined with whole body vibration (WBV) is becoming increasingly popular, although additional effects of WBV in comparison to conventional exercises are still discussed controversially in literature. weiter...

Author: Ritzmann R, Kramer A, Bernhardt S, Gollhofer A
Source: PLoS One, 2014; 9(2): e89905, PMID: 24587114
GID: 3507; Last update: 20.03.2014

Research Studies (2014)

Does progressive resistance and balance exercise reduce falls in residential aged care? Randomized controlled trial protocol for the SUNBEAM program

Introduction: Falls are common among older adults. It is reported that approximately 60% of residents of aged care facilities fall each year. This is a major cause of morbidity and mortality, and a significant weiter...

Author: Hewitt J, Refshauge KM, Goodall S, Henwood T, Clemson L
Source: Clinical Interventions in Aging, 2014; 9: 369-376
GID: 3480; Last update: 25.02.2014
More information: Original Article

Research Studies (2011)

Leg muscle activity level and rate of perceived exertion with different whole-body vibration frequencies in multiple sclerosis patients: An exploratory approach

This study aimed to determine the whole-body vibration (WBV) frequencies that cause the highest average electromyogram (EMG) output in four different muscles, in relation to patients suffering from multiple s weiter...

Author: Karel Hendrik Madou,
Source: Hong Kong Physiotherapy Journal, 2011; 29: 12-19
Keywords: electromyography; multiple sclerosis; perceived exertion; whole-body vibration
GID: 3441; Last update: 04.02.2014

Research Studies (2013)

Intra- and inter-rater reliability of jumping mechanography muscle function assessments.

Muscle function can be assessed through jumping mechanography, where portable ground reaction force plates collect dynamic information as a subject jumps. The aim of this study was to assess both intra- and in weiter...

Author: Matheson LA, Duffy S, Maroof A, Gibbons R, Duffy C, Roth J
Source: J Musculoskelet Neuronal Interact, 2013; 13(4): 480-6, PMID: 24292618
GID: 3419; Last update: 10.01.2014

Research Studies (2011)

Altersabhängige Muskelleistung und -kraft bei Senioren-Leistungssportlern verschiedener Sprungdisziplinen und die Anpassung des Knochens

Author: Böhme SA.
Source: Dissertation, 2011;
GID: 3347; Last update: 11.11.2013
More information: Original Article

Research Studies (2012)

Neuromuskuläres Assessment mit besonderer Betonung der spezifischen Sprungkraft im Kontext mit Knochendichtemessungen bei postmenopausalen Frauen

Author: Luhn F.
Source: Dissertation, 2012;
GID: 3348; Last update: 11.11.2013
More information: Original Article

Research Studies (2013)

A TRI-MODALITY COMPARISON OF VOLUMETRIC BONE MEASURE QUANTIFICATION USING 1.0 TESLA PERIPHERAL MAGNETIC RESONANCE IMAGING, PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY AND HIGHRESOLUTION- PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY IMAGES

This comparative study of peripheral (p) QCT, high-resolution pQCT (hr-pQCT) and 1.0 Tesla pMRI technologies focused on quantifying short-term test-retest reproducibility, validity, one-year detection limit a weiter...

Author: Wong A.K.O.
Source: Open Access Dissertations and Theses. Paper 8464, 2013;
Keywords: Morphometric parameters pQCT vs. HR-pQCT
GID: 3342; Last update: 06.11.2013
More information: Original Article

Scientific Publications (2010)

Osteoporosis in Men Chapter 52: Exercise programs for Pateints with osteoporosis

Author: Felsenberg D., Runge M.
Source: Osteoporosis in Men, 2010; 635-652
GID: 3308; Last update: 17.09.2013

Research Studies (2013)

Cross-sectional assessment of neuromuscular function using mechanography in women and men aged 20-85 years.

Objectives: The aim of this cross-sectional study was to examine the influence of age and sex on neuromuscular function of the lower limbs using mechanography. 704 adults aged 20-85 years from Germany participa weiter...

Author: Dietzel R, Gast U, Heine T, Felsenberg D, Armbrecht G
Source: J Musculoskelet Neuronal Interact, 2013; 13(3): 274-81, PMID: 23989252
GID: 3305; Last update: 10.09.2013
More information: Original Article

Research Studies (2013)

Reference data for jumping mechanography in healthy children and adolescents aged 6-18 years.

Objectives: To present gender-specific pediatric normative data on the main parameters of muscle function assessed using jumping mechanography. Methods: The study population included 796 non-selected Caucasian weiter...

Author: Sumnik Z, Matyskova J, Hlavka Z, Durdilova L, Soucek O, Zemkova D
Source: J Musculoskelet Neuronal Interact, 2013; 13(3): 259-73, PMID: 23989251
GID: 3304; Last update: 10.09.2013
More information: Original Article

Research Studies (2013)

The effect of physiotherapy in addition to testosterone replacement therapy on the efficiency of the motor system in men with hypogonadism.

BACKGROUND AND OBJECTIVE. The aim of this study was to analyze whether the addition of physiotherapy to testosterone replacement therapy provides added benefit in improving functional capacity of the motor syst weiter...

Author: Baceviciene R, Valonyte L, Ceponis J
Source: Medicina (Kaunas), 2013; 49(2): 71-7, PMID: 23888342
GID: 3285; Last update: 27.08.2013

Research Studies (2013)

Mechanography in childhood: references for grip force, multiple one-leg hopping force and whole body stiffness.

Objective: We sought to study and procure reference values for weight-related maximum isometric grip force (MIGF), maximum voluntary force in relation to body weight (Fmvrel) and peak whole body stiffness (pKwb weiter...

Author: Lang I, Busche P, Rakhimi N, Rawer R, Martin DD.
Source: J Musculoskelet Neuronal Interact., 2013; 13(2):: 227-35., PMID: 23728109
GID: 3221; Last update: 07.06.2013
More information: Original Article

Research Studies (2013)

Mechanography in childhood: references for force and power in counter movement jumps and chair rising tests.

Objective: We sought to procure age- and gender- related reference data and study the characteristics of body weight related peak force (pFrel), body mass related peak power (pPrel) for counter movement jumps ( weiter...

Author: Busche P, Rawer R, Rakhimi N, Lang I, Martin DD.
Source: J Musculoskelet Neuronal Interact., 2013; 13(2):: 213-26., PMID: 23728108
GID: 3220; Last update: 07.06.2013
More information: Original Article

Research Studies (2013)

Vibration or Balance Training on Neuromuscular Performance in Osteopenic Women.

Maintaining neuromuscular function in older age is an important topic for aging societies, especially for older women with low bone density who may be at risk of falls and bone fracture. This randomized control weiter...

Author: Stolzenberg N, Belavý DL, Rawer R, Felsenberg D.
Source: Int J Sports Med., 2013; 34(11): 956-62, PMID: 23549694
Keywords: osteoporosis menopause whole body vibration ground reaction force
GID: 3192; Last update: 06.06.2013

Research Studies (2013)

Vitamin D status and muscle function in children with neurofibromatosis type 1 (NF1).

Objectives: The aim of this cross-sectional study was to assess the vitamin D status and muscle function in children with NF1 compared with their unaffected siblings. Methods: NF1 children between 5 and 18 year weiter...

Author: Hockett CW, Eelloo J, Huson SM, Roberts SA, Berry JL, Chaloner C, Rawer R, Mughal MZ.
Source: J Musculoskelet Neuronal Interact., 2013; 13(1): 111-119, PMID: 23445921
GID: 3152; Last update: 14.03.2013
More information: Original Article

Research Studies (2013)

Analysing gait using a force-measuring walkway: intrasession repeatability in healthy children and adolescents.

The goal of this study was to determine the repeatability of gait parameters measured by a force plate gait analysis system (Leonardo Mechanograph((R)) GW) in healthy children. Nineteen healthy children and ado weiter...

Author: Veilleux LN, Ballaz L, Robert M, Lemay M, Rauch F
Source: Comput Methods Biomech Biomed Engin, 2013; (): , PMID: 23360226
GID: 3109; Last update: 02.02.2013

Research Studies (2012)

Agreement between vertical ground reaction force and ground reaction force vector in five common clinical tests.

Mechanography is an innovative method to evaluate lower-limb dynamic muscle function. This technique is generally performed on force platforms that measure only the vertical component of ground reaction force ( weiter...

Author: Veilleux LN, Rauch F, Lemay M, Ballaz L
Source: J Musculoskelet Neuronal Interact, 2012; 12(4): 219-23, PMID: 23196264
GID: 3073; Last update: 08.12.2012
More information: Original Article

Research Studies (2012)

Peripheral QCT sector analysis reveals early exercise-induced increases in tibial bone mineral density.

Objectives: The purpose of this controlled trial was to determine whether subtle changes in mineralization and geometry of the tibia were evident following short term exercise interventions. Methods: Fifty-se weiter...

Author: Evans RK, Negus CH, Centi AJ, Spiering BA, Kraemer WJ, Nindl BC
Source: J Musculoskelet Neuronal Interact, 2012; 12(3): 155-64, PMID: 22947547
GID: 3039; Last update: 09.09.2012
More information: Original Article

Research Studies (2012)

Effect of exercise on bone structural traits, physical performance and body composition in breast cancer patients - A 12-month RCT.

In this 12-month RCT, we examined whether aerobic impact exercise training (3x/week) could facilitate breast cancer survivors" recovery by enhancing their bone structural strength, physical performance and body weiter...

Author: Nikander R, Sievanen H, Ojala K, Kellokumpu-Lehtinen P, Palva T, Blomqvist C, Luoto R, Saarto T
Source: J Musculoskelet Neuronal Interact, 2012; 12(3): 127-35, PMID: 22947544
GID: 3036; Last update: 09.09.2012
More information: Original Article

Research Studies (2012)

Is a small muscle mass index really detrimental for insulin sensitivity in postmenopausal women of various body composition status?

Objectives: We sought to determine if a small muscle mass index (MMI) is actually detrimental for insulin sensitivity when studying a large group of postmenopausal women displaying various body composition stat weiter...

Author: Lebon J, Aubertin-Leheudre M, Bobeuf F, Lord C, Labonte M, Dionne IJ
Source: J Musculoskelet Neuronal Interact, 2012; 12(3): 116-26, PMID: 22947543
GID: 3035; Last update: 09.09.2012
More information: Original Article

Research Studies (2012)

Functional assessment of the muscle-bone unit in the lower leg.

Based on the mechanostat theory and the muscle-bone hypothesis, a methodological assessment of the musculoskeletal status in health and disease should relate maximum muscle force in relation to bone mass and g weiter...

Author: Anliker E, Toigo M
Source: J Musculoskelet Neuronal Interact, 2012; 12(2): 46-55, PMID: 22647277
GID: 2980; Last update: 05.06.2012
More information: Original Article

Research Studies (2012)

Effects of jumping exercise on maximum ground reaction force and bone in 8- to 12-year-old boys and girls: a 9-month randomized controlled trial.

Objectives: To assess adaptations of the lower leg muscle-bone unit in 8- to 12-year-old children following a randomized controlled jumping exercise intervention for 9 months. Methods: Twelve boys and 10 girls weiter...

Author: Anliker E, Dick C, Rawer R, Toigo M
Source: J Musculoskelet Neuronal Interact, 2012; 12(2): 56-67, PMID: 22647278
GID: 2981; Last update: 05.06.2012
More information: Original Article

Research Studies (2012)

Abnormalities in Muscle Density and Muscle Function in Hypophosphatemic Rickets.

Context:Animal studies suggest that hypophosphatemic rickets (HPR) is associated with muscle function deficits, but it is unknown whether humans with HPR have a muscle disorder.Objective:Our objective was to a weiter...

Author: Veilleux LN, Cheung M, Ben Amor M, Rauch F
Source: J Clin Endocrinol Metab, 2012; 97(8): E1492-8, PMID: 22639288
GID: 2979; Last update: 05.06.2012

Research Studies (2012)

Effect of different collegiate sports on cortical bone in the tibia.

Objectives: The purpose of this study was to determine the effect of sports participation on cortical bone in the tibia. Methods: 53 female collegiate athletes (25 cross-country, 16 soccer, and 12 volleyball) a weiter...

Author: Weidauer LA, Eilers MM, Binkley TL, Vukovich MD, Specker BL
Source: J Musculoskelet Neuronal Interact, 2012; 12(2): 68-73, PMID: 22647279
GID: 2982; Last update: 05.06.2012
More information: Original Article

Research Studies (2012)

Muscle force and power in obese and overweight children.

The study investigated differences in skeletal muscle function between obese and non-obese children using a force platform. Forty obese children and adolescents (age range 8 to 18 years; 21 girls) and 40 age- weiter...

Author: Rauch R, Veilleux LN, Rauch F, Bock D, Welisch E, Filler G, Robinson T, Burrill E, Norozi K
Source: J Musculoskelet Neuronal Interact, 2012; 12(2): 80-3, PMID: 22647281
GID: 2983; Last update: 05.06.2012
More information: Original Article

Research Studies (2012)

Muscle-bone characteristics in children with Prader-Willi syndrome.

BACKGROUND: A decrease in muscle mass, low motor performance, and normal lumbar spine bone mineral density (BMD) have been reported in children with Prader-Willi syndrome (PWS). However, these data are limited weiter...

Author: Edouard T, Deal C, Van Vliet G, Gaulin N, Moreau A, Rauch F, Alos N
Source: J Clin Endocrinol Metab, 2012; 97(2): E275-81, PMID: 22162467
GID: 2874; Last update: 06.02.2012

Research Studies (2012)

Is 8 weeks of side-alternating whole-body vibration a safe and acceptable modality to improve functional performance in multiple sclerosis?

Purpose: To examine whether an 8-week period of side-alternating whole-body vibration (WBV) exercise is an acceptable and effective exercise intervention to improve and maintain functional performance in multi weiter...

Author: Mason RR, Cochrane DJ, Denny GJ, Firth EC, Stannard SR
Source: Disabil Rehabil, 2012; 34(8): 647-54, PMID: 21992525
Keywords: MS
GID: 2852; Last update: 06.02.2012

Research Studies (2011)

Side-to-side differences in bone strength in master jumpers and sprinters.

Introduction: This study evaluated side-to-side difference in tibial bone structure, calf muscle cross-sectional area (CSA) and hopping force in master athletes as a result of training for sports with different weiter...

Author: Ireland A, Korhonen M, Heinonen A, Suominen H, Baur C, Stevens S, Degens H, Rittweger J
Source: J Musculoskelet Neuronal Interact, 2011; 11(4): 298-305, PMID: 22130138
GID: 2777; Last update: 06.12.2011
More information: Original Article

Research Studies (2011)

The Muscle Activity In The Lower Limb During Single Legged Hop In Children With Juvienile Idiophathic Arthritis

The one-legged hop was used to assess the muscle function of children diagnosed with Juvenile Idiopathic Arthritis. Vertical hopping relies heavily on the triceps surae musculature, and the calcaneal tendon mak weiter...

Author: Dwyer KD; Kennedy MJ; Lamontagne M; Roth J
Source: ISB, Brussels, 2011; 1162
GID: 2753; Last update: 05.10.2011

Research Studies (2011)

Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise.

Protein calcium sensors of the Homer family have been proposed to modulate the activity of various ion channels and nuclear factor of activated T cells (NFAT), the transcription factor modulating skeletal musc weiter...

Author: Salanova M, Bortoloso E, Schiffl G, Gutsmann M, Belavy DL, Felsenberg D, Furlan S, Volpe P, Blottner D
Source: FASEB J, 2011; (): , PMID: 21885651
Keywords: BBR2
GID: 2748; Last update: 28.09.2011

Research Studies (2011)

Correlation of Different Muscle Function Tests in Older Adults

Background: Evidence is growing that sarcopenia is an independent risk factor for falls and osteoporotic fractures. Definition of sarcopenia based on mass alone is not ideal as muscle function appears to bett weiter...

Author: Buehring B, Fidler E, Krueger D, Binkley N
Source: ASBMR, Anual Meeting 2011, San Diego, 2011;
GID: 2727; Last update: 09.09.2011

Research Studies (2011)

Combined Effects of Whole-Body Vibration, Resistance Exercise, and Vascular Occlusion on Skeletal Muscle and Performance.

The purpose of this study was to evaluate the effects of a new high-intensity training modality comprised of vibration exercise with superimposed resistance exercise and vascular occlusion (vibroX) on skeletal weiter...

Author: Item F, Denkinger J, Fontana P, Weber M, Boutellier U, Toigo M
Source: Int J Sports Med, 2011; 32(10): 781-7, PMID: 21870317
Keywords: enduracne, workout, suqat, Kniebeuge, Ausdauer
#GRFS12
GID: 2690; Last update: 29.08.2011

Research Studies (2011)

Maximum Ground Reaction Force in Relation to Tibial Bone Mass in Children and Adults.

PURPOSE:: To assess maximum voluntary forefoot ground reaction force (Fm1LH) during multiple one-legged hopping (m1LH, a new jumping maneuver) and to determine the correlation between tibial volumetric bone min weiter...

Author: Anliker E, Rawer R, Boutellier U, Toigo M
Source: Med Sci Sports Exerc, 2011; (43): 2102-9, PMID: 21502901
GID: 2632; Last update: 19.04.2011

Research Studies (2010)

Assessment of musculoskeletal system in women with jumping mechanography

The purpose of this study was to investigate and add reference data about the musculoskeletal system in women. The mechanography system of the Leonardo weiter...

Author: Dionyssiotis Y, Galanos A, Michas G, Trovas G, Lyritis GP
Source: Int J Womens Health., 2010; 1: 113-8, PMID: 21072281
GID: 2622; Last update: 07.04.2011

Research Studies (2011)

Additive impact of alfacalcidol on bone mineral density and bone strength in alendronate treated postmenopausal women with reduced bone mass

Objectives: Assessment of additive impact of alfacalcidol 1 weiter...

Author: Felsenberg D, Bock O, Börst H, Armbrecht G, Beller G, Degner C, Stephan-Oelkers M, Schacht E, Mazor Z, Hashimoto J, Roth HJ, Martus P, Runge M
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 34-45, PMID: 21364273
GID: 2587; Last update: 05.03.2011
More information: Original Article

Research Studies (2011)

Gait analysis using a force-measuring gangway: Intrasession repeatability in healthy adults

Objectives: The goal of the present study was to determine the repeatability of gait parameters measured by a force plate gait analysis system (Leonardo Mechanograph® GW). Methods: Fifteen healthy adult partic weiter...

Author: Veilleux LN, Robert M, Ballaz L, Lemay M, Rauch F
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 27-33, PMID: 21364272
Keywords: Gangway
GID: 2586; Last update: 05.03.2011
More information: Original Article

Research Studies (2011)

Inter-limb musculoskeletal differences in competitive ten-pin bowlers: A preliminary analysis

Objectives: To compare musculoskeletal characteristics of the loaded and non-loaded forearm and upper leg of competitive ten-pin bowlers. Methods: 10 competitive bowlers (30.6 weiter...

Author: Young KC, Sherk VD, Bemben DA
Source: J Musculoskelet Neuronal Interact., 2011; 11(1): 21-6, PMID: 21364271
GID: 2585; Last update: 05.03.2011
More information: Original Article

Research Studies (2010)

Relationship of muscle function to auxology in preterm born children at the age of seven years

BACKGROUND/AIMS: To characterize the relationship between muscle function and auxology in preterm born children. METHODS: Forty-five preterm born children (birth weight < or =1,500 g with mean +/- SD: 1,06 weiter...

Author: Fricke O, Roedder D, Kribs A, Tutlewski B, von Kleist-Retzow JC, Herkenrath P, Roth B, Schoenau E
Source: Horm Res Paediatr., 2010; 73(5): 390-7, PMID: 20389111
GID: 2573; Last update: 22.02.2011

Research Studies (2010)

Reproducibility of jumping mechanography in healthy children and adults

Objectives: To describe mechanographic tests that can be performed by patients with a range of functional abilities and to assess the reproducibility of test results in healthy adults and children. Methods: Fif weiter...

Author: Veilleux LN, Rauch F
Source: J Musculoskelet Neuronal Interact., 2010; 10(4): 256-66, PMID: 21116062
GID: 2483; Last update: 02.12.2010
More information: Original Article

Research Studies (1998)

The relationship between isokinetic quadriceps strength test and hop tests for distance and one-legged vertical jump test following anterior cruciate ligament reconstruction

Isokinetic measurements and functional tests are often used to assess function following knee ligament reconstruction using the opposite limb as a control. However, the question of whether the uninvolved leg ma weiter...

Author: Petschnig R, Baron R, Albrecht M
Source: J Orthop Sports Phys Ther., 1998; 28(1): 23-31, PMID: 9653687
GID: 2436; Last update: 19.10.2010

Research Studies (2010)

Jumping mechanography: a potential tool for sarcopenia evaluation in older individuals

Muscular function declines with advancing age and is associated with increased risk for falls and fragility fractures. No single methodology ideally quantitatively evaluates this decline. Jumping mechanography weiter...

Author: Buehring B, Krueger D, Binkley N
Source: J Clin Densitom., 2010; 13(3): 283-91, PMID: 20554231
GID: 2325; Last update: 12.07.2010

Research Studies (2010)

Calf muscle x-ray absorption is reduced in patients with chronic spinal cord injury, but not during 90 days of experimental bed rest

BACKGROUND: Immobilisation leads to muscular atrophy. However, certain types of immobilisation, such as e.g. denervation can also cause a fatty degeneration of skeletal muscle. As fat has lower x-ray absorpti weiter...

Author: Rittweger J
Source: Life in Space for Life on Earth, ESA, Triest, 2010;
Keywords: Muskeldichte, MXA
GID: 2300; Last update: 18.06.2010
More information: Original Article

Research Studies (2009)

Non-invasive (pQCT) biomechanical analysis of the whole human tibia in normal men and women

Author: Feldman S, Capozza R, Mortario P, Yelin I, Reina P, Schiessl H, Rittweger J, Ferretti JL, Cointry GR
Source: ASBMR, 2009;
GID: 2228; Last update: 09.04.2010
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Research Studies (2009)

Structural and biomechanical analysis of the whole tibia by pQCT in trained long-distance runners

Author: Feldman S, Capozza R, Mortarino P. Yelin I, Reina P, Ullna MR, Rittweger J, Ferretti JL, Cointry GR
Source: ASBMR, 2009;
GID: 2229; Last update: 09.04.2010
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Research Studies (2010)

Age-Related Changes in Physical Function in Community-Dwelling People Aged 50-79 Years

[Purpose] We aimed to obtain the mean values for physical function tests in healthy community-dwelling people aged 50-79 years and to compare these values between age decades. [Subjects and Methods] We recr weiter...

Author: Tsubaki A, Kubo M, Kobayashi R, Jigami H, Takahashi HE
Source: J. Phys. Ther. Sci, 2010; 22/1: 23-27
GID: 2231; Last update: 09.04.2010
More information: Original Article

Research Studies (2006)

Building a Better Understanding of Basic Mechanical Principles Through Analysis of the Vertical Jump

An understanding of the basic mechanical principles governing movement is essential for the development of training programs, performance improvement, and injury prevention. The goal of this article is to revie weiter...

Author: Reiser RF, Rocheford EC, Armstrong CJ
Source: Strength and conditioning journal, 2006; 28(4): 70-80
GID: 2135; Last update: 05.01.2010

Research Studies (2009)

EFFECT OF SPORT ACTIVITY ON COUNTER MOVEMENT JUMP PARAMETERS IN JUVENILE STUDENTS

INTRODUCTION: The counter movement jump (CMJ) is a commonly used method in performance diagnostics to measure leg power (Frick et al., 1991). The use of arm movements during jumping can increase the release ve weiter...

Author: Richter A, Lang D, Strutzenberger G, Schwameder H
Source: ISBS, Conference Proceedings Archive, 27 International Conference on Biomechanics in Sports (2009), 2009;
GID: 2124; Last update: 28.12.2009
More information: Original Article

Scientific Publications (2009)

Changes in muscle mass and strength after menopause

Menopause is associated with a natural decline in estrogen, that increases visceral fat mass, decreases bone mass density, muscle mass, and strength. This review will examine the role of menopause transition an weiter...

Author: Maltais ML, Desroches J, Dionne IJ
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 186-97, PMID: 19949277
GID: 2108; Last update: 18.12.2009
More information: Original Article

Research Studies (2009)

Skeletal geometry and indices of bone strength in artistic gymnasts

This review addresses bone geometry and indices of skeletal strength associated with exposure to gymnastic loading during growth. A brief background characterizes artistic gymnastics as a mechanical loading mod weiter...

Author: Dowthwaite JN, Scerpella TA
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 198-214, PMID: 19949278
GID: 2109; Last update: 18.12.2009
More information: Original Article

Research Studies (2009)

Resistive vibration exercise reduces lower limb muscle atrophy during 56-day bed-rest

Objectives: The current study aimed to examine the effectiveness of a resistive vibration exercise countermeasure during prolonged bed-rest in preventing lower-limb muscle atrophy. Methods: 20 male subjects und weiter...

Author: Belavý DL, Miokovic T, Armbrecht G, Rittweger J, Felsenberg D
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 225-35, PMID: 19949280
Keywords: BBR, Galileo Space
GID: 2083; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Age-dependency in bone mass and geometry: a pQCT study on male and female master sprinters, middle and long distance runners, race-walkers and sedentary people

Objective: To investigate whether athletic participation allows master athletes to preserve their good bone health into old age. Methods: Bone strength indicators of the tibia and the radius were obtained of ma weiter...

Author: Wilks DC, Winwood K, Gilliver SF, Kwiet A, Sun LW, Gutwasser C, Ferretti JL, Sargeant AJ, Felsenberg D, Rittweger J
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 236-46, PMID: 19949281
Keywords: Master Athletes
GID: 2084; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Age comparisons of bone density and geometry in men

Objectives: The purposes of this study were to examine tibia bone density and geometry in young and middle aged men, and to explore relationships between pQCT- and DXA-derived body composition variables. Method weiter...

Author: Sherk VD, Karabulut M, Bemben MG, Bemben DA
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 256-62, PMID: 19949283
GID: 2086; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Comparison of pQCT parameters between ulna and radius in retired elite gymnasts: the skeletal benefits associated with long-term gymnastics are bone- and site-specific

Objectives: To compare the skeletal benefits associated with gymnastics between ulna and radius. Methods: 19 retired artistic gymnasts, aged 18-36 years, were compared to 24 sedentary women. Bone mineral conten weiter...

Author: Ducher G, Hill BL, Angeli T, Bass SL, Eser P
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 247-55, PMID: 19949282
GID: 2085; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Muscle and bone adaptations after treadmill training in incomplete Spinal Cord Injury: a case study using peripheral Quantitative Computed Tomography

We describe the use of peripheral Quantitative Computed Tomography (pQCT) to identify musculoskeletal responses to partial body-weight supported treadmill training (BWSTT) in incomplete spinal cord injury (SCI) weiter...

Author: Coupaud S, Jack LP, Hunt KJ, Allan DB
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 288-97, PMID: 19949287
GID: 2087; Last update: 03.12.2009
More information: Original Article

Research Studies (2009)

Normative values for maximum power during motor function assessment of jumping among physically active Japanese

Objectives: To determine the relationship between maximum power relative to body weight (Pmax-rel) and the aging process, and to indicate the target values of improvement of motor function in Japanese individua weiter...

Author: Tsubaki A, Kubo M, Kobayashi R, Jigami H, Takahashi HE
Source: J Musculoskelet Neuronal Interact., 2009; 9(4): 263-7, PMID: 19949284
Keywords: Leonardo Normative Data
GID: 2082; Last update: 02.12.2009
More information: Original Article

Scientific Publications (1992)

Skeletal adaptations during growth

NASA: The authors examine the role of mechanical usage in skeletal development. Principle mechanisms of bone physiology include longitudinal bone growth; modeling drifts; micromodeling; remodeling by the basic weiter...

Author: Jee WS, Frost HM
Source: Triangle., 1992; 31(2/3): 77-88, PMID: 11539347
GID: 2078; Last update: 25.11.2009

Scientific Publications (1998)

Perspectives: some roles of mechanical usage, muscle strength, and the mechanostat in skeletal physiology, disease, and research

Author: Frost HM, Ferretti JL, Jee WS
Source: Calcif Tissue Int., 1998; 62(1): 1-7, PMID: 9405724
GID: 2079; Last update: 25.11.2009

Research Studies (2007)

The "Functional Muscle-Bone Unit": probing the relevance of mechanical signals for bone development in children and adolescents

The present text deals with the relationship of muscle force and mass to bone mass and geometry in the developing skeleton of children and adolescents. Recent results of the last ten years are discussed with re weiter...

Author: Fricke O, Schoenau E
Source: Growth Horm IGF Res., 2007; 17(1): 1-9, PMID: 17194607
GID: 2076; Last update: 25.11.2009

Scientific Publications (1992)

The role of changes in mechanical usage set points in the pathogenesis of osteoporosis

Mechanical usage (MU) effects on modeling drifts and BMU-based remodeling affect bone mass in defined ways. Decreased MU stops additions of bone by modeling and increases removal of bone next to marrow by remod weiter...

Author: Frost HM
Source: J Bone Miner Res., 1992; 7(3): 253-61, PMID: 1585826
GID: 2077; Last update: 25.11.2009

Research Studies (2005)

Examining the developing skeletal muscle: Why, what and how

This review focuses on methodological concepts in the evaluation of skeletal muscle function, taking into account classical muscle physiology, the developing motor system in children and anthropometric paramete weiter...

Author: Fricke O, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2005; 5(3): 225-31, PMID: 16172513
GID: 2074; Last update: 25.11.2009
More information: Original Article

Research Studies (2008)

Experimentelle und klinische Validierung der mittels peripherer Quantitativer Computertomographie (pQCT) berechneten biomechanischen Parameter Flächenträgheitsmoment I, Widerstandsmoment W und anderer Festigkeitsindices

Die Zielsetzung dieser Arbeit war die Überprüfung der Richtigkeit der Berechnung der Biegesteifigkeit peripherer Knochen mittels pQCT Messung und deren dichtebasierte Berechnung des Flächenträgheitsmomentes weiter...

Author: Beller GR
Source: Dissertation, 2008;
GID: 1974; Last update: 07.10.2009
More information: Original Article

Research Studies (2008)

Association between long-term consumption of soft drinks and variables of bone modeling and remodeling in a sample of healthy German children and adolescents

BACKGROUND: Soft drinks are thought to displace milk in diets of children and adolescents and therefore might affect variables of bone modeling and remodeling. OBJECTIVE: We assessed the association between lon weiter...

Author: Libuda L, Alexy U, Remer T, Stehle P, Schoenau E, Kersting M
Source: Am J Clin Nutr., 2008; 88(6): 1670-7, PMID: 19064530
GID: 1941; Last update: 22.09.2009

Research Studies (2009)

History of amenorrhoea compromises some of the exercise-induced benefits in cortical and trabecular bone in the peripheral and axial skeleton: a study in retired elite gymnasts

BACKGROUND: Female gymnasts frequently present with overt signs of hypoestrogenism, such as late menarche or menstrual dysfunction. The objective was to investigate the impact of history of amenorrhoea on the e weiter...

Author: Ducher G, Eser P, Hill B, Bass S
Source: Bone., 2009; 45(4): 760-7, PMID: 19573632
GID: 1922; Last update: 07.09.2009

Research Studies (2009)

Influence of exercise mode and osteogenic index on bone biomarker responses during short-term physical training

Prescribing exercise based on intensity, frequency, and duration of loading may maximize osteogenic responses in bone, but a model of the osteogenic potential of exercise has not been established in humans. In weiter...

Author: Lester ME, Urso ML, Evans RK, Pierce JR, Spiering BA, Maresh CM, Hatfield DL, Kraemer WJ, Nindl BC
Source: Bone., 2009; 45(4): 768-76, PMID: 19520194
GID: 1923; Last update: 07.09.2009

Scientific Publications (2008)

Mechanical influences on bone development in children

This review focuses on methodological concepts in the evaluation of skeletal muscle function and on adaptation. It is now thought that the critical property of bone is strength rather than weight, and that cont weiter...

Author: Schoenau E, Fricke O
Source: Eur J Endocrinol., 2008; 159 Suppl 1: S27-31, PMID: 18787052
GID: 1856; Last update: 28.07.2009
More information: Original Article

Scientific Publications (2008)

The "functional muscle-cartilage unit": a reasonable approach to describe a putative relationship between muscle force and longitudinal growth at the forearm in children and adolescents

BACKGROUND: Several reports give evidence that the perichondral ossificiation of bone tubes (modeling) strongly depends on muscular forces in children and adolescents. The present analyses intend to investigate weiter...

Author: Fricke O, Beccard R, Semler O, Land C, Stabrey A, Tutlewski B, Remer T, Schoenau E
Source: Horm Res., 2008; 70(5): 285-93, PMID: 18824867
GID: 1855; Last update: 28.07.2009

Scientific Publications (2008)

Local body composition is associated with gender differences of bone development at the forearm in puberty

BACKGROUND/AIMS: The present analyses intend to clarify if gender and puberty modify the relationship between bone development (modeling and remodeling) and fat mass at the forearm. METHODS: Data were collected weiter...

Author: Fricke O, Sumnik Z, Tutlewski B, Stabrey A, Remer T, Schoenau E
Source: Horm Res., 2008; 70(2): 105-11, PMID: 18547958
GID: 1857; Last update: 28.07.2009

Research Studies (2004)

Muscle mass during childhood--relationship to skeletal development

Bone densitometric data often are difficult to interpret in children and adolescents because of large inter- and intraindividual variations in bone size. Here, we propose a functional approach to bone densitome weiter...

Author: Schoenau E, Neu MC, Manz F
Source: J Musculoskelet Neuronal Interact., 2004; 4(1): 105-8, PMID: 15615084
GID: 1852; Last update: 27.07.2009
More information: Original Article

Research Studies (2009)

Assessment of material, structural, and functional properties of the human skeleton by pQCT systems

Peripheral quantitative computed tomography (pQCT) systems measure bone parameters noninvasively using low radiation doses. This limits image resolution but is practical for the diagnosis and quantitative monit weiter...

Author: Roldán EJ, Bogado CE
Source: Curr Osteoporos Rep., 2009; 7(2): 37-41, PMID: 19631026
GID: 1844; Last update: 27.07.2009

Research Studies (2008)

Precision of the XCT 3000 and comparison of densitometric measurements in distal radius scans between XCT 3000 and XCT 2000 peripheral quantitative computed tomography scanners.

Researchers conducting longitudinal studies face challenges as technology evolves and data collection equipment is upgraded from older to newer models. In this study, we report precision error and associations weiter...

Author: Koenig C, Wey H, Binkley T.
Source: J Clin Densitom., 2008; Oct-Dec;11(4):: 575-80, PMID: 18715808
GID: 1846; Last update: 27.07.2009

Research Studies (2008)

Bone mineral density alterations in upper and lower extremities 12 months after stroke measured by peripheral quantitative computed tomography and DXA.

To evaluate the loss of trabecular and cortical bone mineral density (BMD) and geometric parameters of bone strength expressed by stress-strain index (SSI) in the proximal and distal forearm and the alterations weiter...

Author: Lazoura O, Groumas N, Antoniadou E, Papadaki PJ, Papadimitriou A, Thriskos P, Fezoulidis I, Vlychou M.
Source: J Clin Densitom., 2008; 11(4):: 511-7, PMID: 18639477
GID: 1837; Last update: 21.07.2009

Research Studies (2009)

Influence of weight reduction on muscle performance and bone mass, structure and metabolism in obese premenopausal women.

Muscle performance, body composition and bone mass at the lumbar spine and proximal femur with DXA, structural traits at the tibia and radius with pQCT, and biomarkers of bone metabolism were assessed at baseli weiter...

Author: Uusi-Rasi K, Sievanen H, Kannus P, Pasanen M, Kukkonen-Harjula K, Fogelholm M
Source: J Musculoskelet Neuronal Interact, 2009; 9(2): 72-80, PMID: 19516082
GID: 1836; Last update: 21.07.2009
More information: Original Article

Research Studies (2009)

Intensity, repetitiveness, and directionality of habitual adolescent mobility patterns influence the tibial diaphysis morphology of athletes.

Mobility patterns affect the loads placed on the lower limbs during locomotion and may influence variation in lower limb diaphyseal robusticity and shape. This relationship commonly forms the basis for inferri weiter...

Author: Shaw CN, Stock JT
Source: Am J Phys Anthropol, 2009; 140(1): 149-59, PMID: 19358289
GID: 1811; Last update: 05.05.2009

Research Studies (2009)

Habitual throwing and swimming correspond with upper limb diaphyseal strength and shape in modern human athletes.

Variation in upper limb long bone cross-sectional properties may reflect a phenotypically plastic response to habitual loading patterns. Structural differences between limb bones have often been used to infer p weiter...

Author: Shaw CN, Stock JT
Source: Am J Phys Anthropol, 2009; 140(1): 160-72, PMID: 19358297
GID: 1812; Last update: 05.05.2009

Research Studies (2008)

Study of bone density by pQCT analysis in healthy adults and patients with B-thalassemia major and intermedia

BACKGROUND: Bone changes are a prominent symptom of beta-thalassemias, related to expansion of bone marrow and reduction of bone density. Conventional treatment ameliorates bone changes and improves survival, t weiter...

Author: Ladis V, Raptou P, Rigatou E, Chouliaras G, Galanos A, Korres D, Kattamis C
Source: Pediatr Endocrinol Rev., 2008; 6 Suppl 1: 127-31, PMID: 19360988
GID: 1804; Last update: 16.04.2009

Research Studies (2009)

Long-Term Leisure Time Physical Activity and Properties of Bone: A Twin Study

Abstract Effects of physical activity on bone properties when controlled for genetic effects are not fully understood. We aimed to investigate association between long-term leisure time physical activity (LTPA) weiter...

Author: Ma H, Leskinen T, Alen M, Cheng S, Sipilä S, Heinonen A, Kaprio J, Suominen H, Kujala UM
Source: J Bone Miner Res., 2009; 24/8: 1427-33, PMID: 19335223
GID: 1801; Last update: 16.04.2009

Research Studies (2009)

Bone mass and geometry of the tibia and the radius of master sprinters, middle and long distance runners, race-walkers and sedentary control participants: a pQCT study.

Mechanical loading is thought to be a determinant of bone mass and geometry. Both ground reaction forces and tibial strains increase with running speed. This study investigates the hypothesis that surrogates of weiter...

Author: Wilks DC, Winwood K, Gilliver SF, Kwiet A, Chatfield M, Michaelis I, Sun LW, Ferretti JL, Sargeant AJ, Felsenberg D, Rittweger J
Source: Bone, 2009; 45(1): 91-7, PMID: 19332164
GID: 1800; Last update: 16.04.2009

Research Studies (2009)

Quantification of bone mineral density precision according to repositioning errors in peripheral quantitative computed tomography (pQCT) at the radius and tibia

Peripheral quantitative computed tomography (pQCT) is increasingly being used to measure bone mineral density (BMD) in both research and clinical practice to monitor BMD changes. Repeated measurements in long-t weiter...

Author: Sun L, Beller G, Felsenberg D
Source: J Musculoskelet Neuronal Interact., 2009; 9(1): 18-24, PMID: 19240364
GID: 1798; Last update: 15.04.2009
More information: Original Article

Research Studies (2009)

Distal Radius Strength: A Comparison of DXA-Derived vs pQCT-Measured Parameters in Adolescent Females

Although quantitative computed tomography (QCT) is considered the gold standard for in vivo densitometry, dual-energy X-ray absorptiometry (DXA) scans assess larger bone regions and are more appropriate for ped weiter...

Author: Dowthwaite JN, Hickman RM, Kanaley JA, Ploutz-Snyder RJ, Spadaro JA, Scerpella TA
Source: J Clin Densitom., 2009; 12(1): 42-53, PMID: 19084448
GID: 1732; Last update: 12.03.2009

Research Studies (2008)

Body composition, volumetric and areal bone parameters in male-to-female transsexual persons

CONTEXT: Male-to-female (M-->F) transsexual persons undergo extreme changes in gonadal hormone concentrations, both by pharmacological and surgical interventions. Given the importance of sex steroids for develo weiter...

Author: Lapauw B, Taes Y, Simoens S, Van Caenegem E, Weyers S, Goemaere S, Toye K, Kaufman JM, T"Sjoen GG
Source: Bone., 2008; 43(6): 1016-21, PMID: 18835591
Keywords: transsexual, body composition, bone size
GID: 1727; Last update: 18.02.2009

Research Studies (2009)

Well-nourished cystic fibrosis patients have normal mineral density, but reduced cortical thickness at the forearm

SUMMARY: Our goal was to assess mineral density and geometry of the cortex at the level of the forearm in adolescents and young adults with cystic fibrosis, using peripheral quantitative computed tomography. We weiter...

Author: Louis O, Clerinx P, Gies I, De Wachter E, De Schepper J
Source: Osteoporos Int., 2009; 20(2): 309-14, PMID: 18536951
Keywords: cystic fibrosis bone geometry cortical thickness
GID: 1729; Last update: 18.02.2009

Research Studies (2009)

Beta-adrenergic blockade and leptin replacement effectively mitigate disuse bone loss

Our objective was to test effects of beta-adrenergic blockade on hindlimb unloading (HU)-induced bone loss and serum leptin and to compare these responses with those observed with leptin replacement. Adult male weiter...

Author: Baek K, Bloomfield SA
Source: J Bone Miner Res., 2009; 24(5): 792-9, PMID: 19113907
GID: 1725; Last update: 17.02.2009

Research Studies (2009)

Bone loss in the lower leg during 35 days of bed rest is predominantly from the cortical compartment.

Immobilization-induced bone loss is usually greater in the epiphyses than in the diaphyses. The larger fraction of trabecular bone in the epiphyses than in the diaphyses offers an intuitive explanation to acco weiter...

Author: Rittweger J, Simunic B, Bilancio G, De Santo NG, Cirillo M, Biolo G, Pisot R, Eiken O, Mekjavic IB, Narici M
Source: Bone, 2009; 44(4): 612-8, PMID: 19168165
Keywords: BedRest
GID: 1716; Last update: 17.02.2009

Research Studies (2009)

Serum estradiol is associated with volumetric BMD and modulates the impact of physical activity on bone size at the age of peak bone mass: a study in healthy male siblings.

This study investigates determinants of peak bone mass (PBM) in healthy men, focusing on effects and interactions of parameters reflecting mechanical loading and sex steroids. Healthy male siblings (n = 677; 2 weiter...

Author: Lapauw BM, Taes Y, Bogaert V, Vanbillemont G, Goemaere S, Zmierczak HG, De Bacquer D, Kaufman JM
Source: J Bone Miner Res, 2009; 24(6): 1075-85, PMID: 19113912
GID: 1724; Last update: 17.02.2009

Research Studies (2009)

A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6-19 years.

SUMMARY: We have produced paediatric reference data for forearm sites using the Stratec XCT-2000 peripheral quantitative computed tomography scanner. These data are intended for clinical and research use and w weiter...

Author: Ashby RL, Ward KA, Roberts SA, Edwards L, Mughal MZ, Adams JE
Source: Osteoporos Int, 2009; 20(8): 1337-46, PMID: 19066709
GID: 1726; Last update: 17.02.2009

Research Studies (2009)

Tibial geometry in individuals with neurofibromatosis type 1 without anterolateral bowing of the lower leg using peripheral quantitative computed tomography.

INTRODUCTION: Lower leg bowing with tibial pseudarthrosis is associated with neurofibromatosis type 1 (NF1). The objective of the study is to determine if the geometry of the lower limb in individuals with neur weiter...

Author: Stevenson DA, Viskochil DH, Carey JC, Slater H, Murray M, Sheng X, D"Astous J, Hanson H, Schorry E, Moyer-Mileur LJ
Source: Bone, 2009; 44(4): 585-9, PMID: 19118659
GID: 1722; Last update: 17.02.2009

Research Studies (2007)

Vertical jump performance after 90 days bed rest with and without flywheel resistive exercise, including a 180 days follow-up

Muscle atrophy and neuromuscular de-conditioning occur in response to space flight and bed-rest. In this study, we investigated the efficacy of flywheel training to conserve jumping power and height during 90 d weiter...

Author: Rittweger J, Felsenberg D, Maganaris C, Ferretti JL
Source: Eur J Appl Physiol., 2007; 100(4): 427-36, PMID: 17406887
Keywords: BBR, Berlin BedRest Study, ESA, Galileo Space
GID: 1776; Last update: 06.02.2009

Research Studies (2009)

Sprint and endurance power and ageing: an analysis of master athletic world records

Human physical performance is notably reduced with ageing. Although the effects of ageing are often compounded by disuse, the study of master athletes provides an opportunity for investigating the effects of ag weiter...

Author: Rittweger J, di Prampero PE, Maffulli N, Narici MV
Source: Proc Biol Sci., 2009; 276(1657): 683-9, PMID: 18957366
GID: 1773; Last update: 06.02.2009

Research Studies (2008)

Changes in Volumetric Bone Density and Strength at the Tibial Midshaft in Boys and Girls during Growth

Author: Ahamed Y, Cooper D ML, Burrows M, Braid S, McKay H
Source: ASBMR, 2008;
Keywords: Children
GID: 1772; Last update: 28.01.2009
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Research Studies (2008)

Muscle-bone relationships in the lower leg of healthy pre-pubertal females and males

Muscle-bone relationships in healthy pre-pubertal children were investigated using four muscle measures as predictors of tibial strength: 66% tibia cross-sectional muscle area (CSMA) by pQCT; leg lean mass (LLM weiter...

Author: Binkley TL, Specker BL
Source: J Musculoskelet Neuronal Interact., 2008; 8(3): 239-43, PMID: 18799856
Keywords: Muscle-bone, Pre-pubertal, pQCT, Cross-sectional Muscle Area, Bone Strength
GID: 1690; Last update: 21.01.2009
More information: Original Article

Research Studies (2008)

Peripheral quantitative computed tomography of the proximal radius in young subjects - New reference data and interpretation of results

The aim of this contribution is to provide reference data for peripheral quantitative computed tomography (Stratec XCT2000(R)) performed at the proximal radius (the so-called "65% site") of young subjects and t weiter...

Author: Rauch F, Schoenau E
Source: J Musculoskelet Neuronal Interact., 2008; 8(3): 217-26, PMID: 18799854
Keywords: Bone Geometry, Bone Mineral Density, Bone Size, Children, Peripheral Quantitative Computed Tomography
GID: 1689; Last update: 21.01.2009
More information: Original Article

Research Studies (2009)

Bone mass and structure in adolescents with type 1 diabetes compared to healthy peers

SUMMARY: We measured bone mass and structure using pQCT and DXA in adolescents with Type 1 diabetes and compared the results with those of healthy peers. Our results showed that diabetes is associated with redu weiter...

Author: Saha MT, Sievänen H, Salo MK, Tulokas S, Saha HH
Source: Osteoporos Int., 2009; 20(8): 1401-6, PMID: 19083073
Keywords: Adolescence . Bone fragility . Bone mineral content . Osteoporosis . Type 1 diabetes
GID: 1696; Last update: 21.01.2009

Research Studies (2009)

The effects of high potassium consumption on bone mineral density in a prospective cohort study of elderly postmenopausal women

SUMMARY: Few studies have investigated the long-term effects of potassium intake on BMD. In a cohort of 266 elderly women, we found that baseline potassium intake as reflected by 24-hour urine potassium excreti weiter...

Author: Zhu K, Devine A, Prince RL
Source: Osteoporos Int., 2009; 20(2): 335-40, PMID: 18575949
Keywords: Bone mineral density . Dual energy x-ray absorptiometry . Elderly women . Peripheral quantitative computed tomography . Potassium . Trabecular bone
GID: 1695; Last update: 21.01.2009

Research Studies (2008)

Asymmetric bone adaptations to soleus mechanical loading after spinal cord injury

The purpose of this report is to examine longitudinal bone mineral density (BMD) changes in individuals with spinal cord injury (SCI) who began unilateral soleus electrical stimulation early after injury. Twelv weiter...

Author: Dudley-Javoroski S, Shields RK
Source: J Musculoskelet Neuronal Interact., 2008; 8(3): 227-38, PMID: 18799855
Keywords: Spinal chord injury, bone adaptation, Peripheral Quantitative Computed Tomography, Electrical Stimulation, Compression, Tension
GID: 1697; Last update: 21.01.2009
More information: Original Article

Research Studies (2009)

Contrast agent-enhanced computed tomography of articular cartilage: association with tissue composition and properties.

BACKGROUND: Contrast agent-enhanced computed tomography may enable the noninvasive quantification of glycosaminoglycan (GAG) content of articular cartilage. It has been reported that penetration of the negative weiter...

Author: Silvast TS, Jurvelin JS, Aula AS, Lammi MJ, Toyras J
Source: Acta Radiol, 2009; 50(1): 78-85, PMID: 19052932
GID: 1666; Last update: 12.12.2008

Research Studies (2008)

The effect of L-arginine administration on muscle force and power in postmenopausal women

Previously published data (J Bone Miner Res (2005); 20: 471) did not give evidence that the administration of the nitric oxide precursor L-arginine increases bone formation and decreases bone resorption in post weiter...

Author: Fricke O, Baecker N, Heer M, Tutlewski B, Schoenau E
Source: Clin Physiol Funct Imaging., 2008; 28(5): 307-11, PMID: 18510549
Keywords: cross-sectional muscle area; L-arginine; maximal isometric grip force; nitric oxide; peak jump force; peak jump power
GID: 1675; Last update: 12.12.2008

Research Studies (2006)

Musculoskeletal plasticity after acute spinal cord injury: effects of long-term neuromuscular electrical stimulation training

Maintaining the physiologic integrity of paralyzed limbs may be critical for those with spinal cord injury (SCI) to be viable candidates for a future cure. No long-term intervention has been tested to attempt t weiter...

Author: Shields RK, Dudley-Javoroski S
Source: J Neurophysiol., 2006; 95(4): 2380-90, PMID: 16407424
Keywords: spinal chord injury electrical stimulation
GID: 1676; Last update: 12.12.2008

Research Studies (2009)

Longitudinal Assessment of Bone Density and Structure in an Incident Cohort of Children With Crohn"s Disease

BACKGROUND & AIMS: The impact of childhood Crohn"s disease (CD) and its therapies on volumetric bone mineral density (vBMD), bone structure, and muscle mass have not been established. The objective of this long weiter...

Author: Dubner SE, Shults J, Baldassano RN, Zemel BS, Thayu M, Burnham JM, Herskovitz RM, Howard KM, Leonard MB
Source: Gastroenterology., 2009; 136: 123-130, PMID: 19026647
Keywords: bone geometry, Crohn, muscle children bone geometry
GID: 1670; Last update: 12.12.2008

Research Studies (2009)

Divergent Effects of Glucocorticoids on Cortical and Trabecular Compartment Bone Mineral Density in Childhood Nephrotic Syndrome

Abstract Glucocorticoid (GC) effects on skeletal development have not been established. The objective of this peripheral quantitative computed tomography (pQCT) study was to assess volumetric bone mineral densi weiter...

Author: Wetzsteon RJ, Shults J, Zemel BS, Gupta PU, Burnham JM, Herskovitz RM, Howard KM, Leonard MB
Source: J Bone Miner Res., 2009; 24(3):: 503-13, PMID: 19016583
GID: 1669; Last update: 12.12.2008

Research Studies (2009)

Vitamin D status and muscle function in post-menarchal adolescent girls

Context: There has been a resurgence of vitamin D deficiency among infants, toddlers and adolescents in the United Kingdom. Myopathy is an important clinical symptom of vitamin D deficiency, yet it has not been weiter...

Author: Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, Mughal Z
Source: J Clin Endocrinol Metab., 2009; 94(2): 559-563, PMID: 19033372
GID: 1674; Last update: 12.12.2008

Research Studies (2008)

Bone structure and volumetric BMD in overweight children: a longitudinal study

The effect of excess body fat on bone strength accrual is not well understood. Therefore, we assessed bone measures in healthy weight (HW) and overweight (OW) children. Children (9-11 yr) were classified as HW weiter...

Author: Wetzsteon RJ, Petit MA, Macdonald HM, Hughes JM, Beck TJ, McKay HA
Source: J Bone Miner Res., 2008; 23(12): 1946-53, PMID: 18684083
GID: 1655; Last update: 02.12.2008

Research Studies (2003)

Veränderungen der Knochenstruktur der Tibia, quantifiziert mit der pQCT, bei kleinwüchsigen Kindern und Jugendlichen unter Therapie mit Wachstumshormon

Als Prädiktoren für das Wachstum unter WH-Therapie werden auxiologische und laborchemische Parameter eingesetzt. Diese prospektive Studie evaluiert die Knochenstruktur der Tibia vor und während einer Therapi weiter...

Author: THOMAS SCHWAB
Source: Dissertation, 2003;
Keywords: children bone geometry, growth hormone
GID: 1597; Last update: 19.11.2008
More information: Original Article

Research Studies (1994)

The impact of degenerative spinal changes on the correlation of peripheral and axial bone density

Results of bone density measurements by quantitative computed tomography of the peripheral skeleton (pQCT) were compared with those of measurements at the axial skeleton with a view to study the effects of dege weiter...

Author: Schneider P, Börner W
Source: Nuklearmedizin., 1994; 33(4): 138-43, PMID: 7971288
Keywords: comparison axial peripheral bone density sensitivity
GID: 1636; Last update: 19.11.2008

Research Studies (2008)

Impact on bone of an estrogen receptor-alpha gene loss of function mutation

CONTEXT: The kindred described is the only known instance of a germ line loss of function mutation of estrogen receptor (ER)-alpha. OBJECTIVE: Our objective was to assess the impact of a loss of function mutati weiter...

Author: Smith EP, Specker B, Bachrach BE, Kimbro KS, Li XJ, Young MF, Fedarko NS, Abuzzahab MJ, Frank GR, Cohen RM, Lubahn DB, Korach KS
Source: J Clin Endocrinol Metab., 2008; 93(8): 3088-96, PMID: 18505767
Keywords: estrogen receptor gene
GID: 1571; Last update: 11.11.2008

Research Studies (2008)

Bone steady-state is established at reduced bone strength after spinal cord injury: a longitudinal study using peripheral quantitative computed tomography (pQCT)

Spinal cord injury (SCI) is associated with a marked and rapid sublesional bone loss. So far, reports about the time course of adaptive changes in bone mass and structure in people with chronic and complete SCI weiter...

Author: Frotzler A, Berger M, Knecht H, Eser P
Source: Bone., 2008; 43(3): 549-55, PMID: 18567554
Keywords: spinal chord injury bone strength
GID: 1577; Last update: 11.11.2008

Research Studies (2008)

Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions

The International Society for Clinical Densitometry (ISCD) has developed Official Positions for the clinical use of dual-energy X-ray absorptiometry (DXA) and non-DXA technologies. While only DXA can be used fo weiter...

Author: Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg D, Ito M, Prevrhal S, Hans DB, Lewiecki EM
Source: J Clin Densitom., 2008; 11(1): 123-62, PMID: 18442757
GID: 1537; Last update: 06.11.2008

Research Studies (2008)

BMD and bone geometry in transtibial and transfemoral amputees

Prolonged unloading of bone(s) in the residual limb after amputation may cause significant bone loss in the hip and distal bony end of the residual limb. The purpose of this study was to examine the effect of a weiter...

Author: Sherk VD, Bemben MG, Bemben DA
Source: J Bone Miner Res., 2008; 23(9): 1449-57, PMID: 18410229
GID: 1550; Last update: 06.11.2008

Research Studies (2008)

Improved peripheral cortical bone geometry after surgical treatment of primary hyperparathyroidism in postmenopausal women

CONTEXT: Cortical bone geometry is one of the most important components of bone strength. Excess endogenous PTH or intermittent PTH administration affects cortical bone geometry; however, the changes in cortica weiter...

Author: Kaji H, Yamauchi M, Nomura R, Sugimoto T
Source: J Clin Endocrinol Metab., 2008; 93(8): 3045-50, PMID: 18544624
Keywords: bone geometry, pth primary hyperparathyreoidism
GID: 1553; Last update: 06.11.2008

Research Studies (2008)

Tibial subchondral trabecular volumetric bone density in medial knee joint osteoarthritis using peripheral quantitative computed tomography technology

OBJECTIVE: Knee osteoarthritis (OA) is an organ-level failure of the joint involving pathologic changes in articular cartilage and bone. This cross-sectional study compared apparent volumetric bone mineral dens weiter...

Author: Bennell KL, Creaby MW, Wrigley TV, Hunter DJ
Source: Arthritis Rheum., 2008; 58(9): 2776-85, PMID: 18759296
GID: 1554; Last update: 06.11.2008

Research Studies (2008)

Tibial bone geometry in chronic stroke patients: influence of sex, cardiovascular health, and muscle mass

This study aimed to examine the geometry of the tibia in chronic stroke survivors. Fifty-five ambulatory individuals with chronic stroke were included in the study. pQCT was used to obtain a cross-sectional sca weiter...

Author: Pang MY, Ashe MC, Eng JJ
Source: J Bone Miner Res., 2008; 23(7): 1023-30, PMID: 18302505
Keywords: bone geometry, heart disease, muscle
GID: 1543; Last update: 06.11.2008

Research Studies (2008)

Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits

OBJECTIVE: To identify determinants of musculoskeletal deficits (muscle cross-sectional area [mCSA], trabecular volumetric bone mineral density [vBMD], and cortical bone strength [section modulus]) in patients weiter...

Author: Burnham JM, Shults J, Dubner SE, Sembhi H, Zemel BS, Leonard MB
Source: Arthritis Rheum., 2008; 58(8): 2518-27, PMID: 18668565
GID: 1548; Last update: 06.11.2008

Research Studies (2008)

Mechanographic characteristics of adolescents and young adults with congenital heart disease

The present study comprised 29 adolescents and young adults (15 females, 14 males; aged 14.1-23.9 years) with congenital heart disease (CHD) and focused on the interaction between the biomechanical system and C weiter...

Author: Fricke O, Witzel C, Schickendantz S, Sreeram N, Brockmeier K, Schoenau E
Source: Eur J Pediatr., 2008; 167(3): 331-6, PMID: 17516086
GID: 1559; Last update: 06.11.2008

Research Studies (2008)

Characterising cortical density in the mid-tibia: intra-individual variation in adolescent girls and boys

BACKGROUND: Inter-individual differences in cortical bone volumetric density (CoD), such as those related to sex, are a product of differences in remodelling rates. While cortical bone is often treated as a uni weiter...

Author: Cooper DM, Ahamed Y, Macdonald HM, McKay HA
Source: Br J Sports Med., 2008; 42(8): 690-5, PMID: 18635740
Keywords: Children, adolescents, cortical density
GID: 1547; Last update: 06.11.2008

Research Studies (2008)

Differences in physical fitness of male and female recruits in gender-integrated army basic training

PURPOSE: To evaluate gender differences in physical fitness before and after a 4-month gender-integrated basic training (BT) course and to determine whether this program effectively narrowed the differences bet weiter...

Author: Yanovich R, Evans R, Israeli E, Constantini N, Sharvit N, Merkel D, Epstein Y, Moran DS
Source: Med Sci Sports Exerc., 2008; 40(11 Suppl): S654-9, PMID: 18849869
GID: 1562; Last update: 06.11.2008

Research Studies (2007)

Long-bone changes after pamidronate discontinuation in children and adolescents with osteogenesis imperfecta

Cyclical intravenous pamidronate is a widely used symptomatic therapy in moderate to severe osteogenesis imperfecta (OI). The effects of treatment discontinuation on long bone development have not been characte weiter...

Author: Rauch F, Cornibert S, Cheung M, Glorieux FH
Source: Bone., 2007; 40(4): 821-7, PMID: 17223617
Keywords: bisphosphonates, children, adolescents, osteogenesis imperfecta
GID: 1532; Last update: 26.09.2008

Research Studies (2008)

Bone Volumetric Density, Geometry and Strength in Female and Male Collegiate Runners

Author: Thiescafer AJ, Hughes JM, Popp KL, Wetzsteon RJ, Stovitz SD, Kaufman BC, Kurzer MS, Petit MA
Source: ASBMR, 2008;
GID: 1533; Last update: 26.09.2008
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Research Studies (2008)

Jumping Mechanography Safely Evaluates Muscle Performance in Older Adults

Neuromuscular function declines with advancing age and is strongly associated with increased risk for falls, hip fractures and decreased quality of life. A variety of tests, e.g., chair-rise or timed-up-and-go, weiter...

Author: Buehring B, Valentine S, Woods A, Checovich M, Krueger D, Binkley N
Source: ASBMR 2008, 2008;
GID: 1529; Last update: 19.09.2008
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Research Studies (2008)

Genetic and environmental influence on structural strength of weight-bearing and non-weight-bearing bone: a twin study

A bivariate genetic analysis among 217 older female twin pairs showed that, although the structural strength of tibia and radius are mainly regulated by same genetic and environmental factors, the tibia is more weiter...

Author: Mikkola TM, Sipilä S, Rantanen T, Sievänen H, Suominen H, Kaprio J, Koskenvuo M, Kauppinen M, Heinonen A
Source: J Bone Miner Res., 2008; 23(4): 492-8, PMID: 18072876
Keywords: twins, genetics, bone geometry
GID: 1510; Last update: 09.09.2008

Research Studies (2008)

Longitudinal changes in BMD and bone geometry in a population-based study

We prospectively examined vBMD and structural bone parameters assessed by QCT among participants of the InCHIANTI study over a 6-yr follow-up. Periosteal apposition occurred both in men and women. Endocortical weiter...

Author: Lauretani F, Bandinelli S, Griswold ME, Maggio M, Semba R, Guralnik JM, Ferrucci L
Source: J Bone Miner Res., 2008; 23(3): 400-8, PMID: 17997708
Keywords: longitudinal study, osteoporosis, periosteal apposition, endocortical resorption, BMD, bone geometry
GID: 1506; Last update: 09.09.2008

Research Studies (2008)

Muscle function improves during growth hormone therapy in short children born small for gestational age: results of a peripheral quantitative computed tomography study on body composition

BACKGROUND: Short small for gestational age (SGA) children can be affected by a lack of muscle mass rather than fat mass. They also face a high risk of the metabolic syndrome developing after childhood. It is n weiter...

Author: Schweizer R, Martin DD, Schönau E, Ranke MB
Source: J Clin Endocrinol Metab., 2008; 93(8): 2978-83, PMID: 18505766
Keywords: muscle groth hormone, growth retardation
GID: 1515; Last update: 09.09.2008

Research Studies (2008)

In vivo magnetic resonance detects rapid remodeling changes in the topology of the trabecular bone network after menopause and the protective effect of estradiol

INTRODUCTION: Estrogen depletion after menopause is accompanied by bone loss and architectural deterioration of trabecular bone. The hypothesis underlying this work is that the microMRI-based virtual bone biops weiter...

Author: Wehrli FW, Ladinsky GA, Jones C, Benito M, Magland J, Vasilic B, Popescu AM, Zemel B, Cucchiara AJ, Wright AC, Song HK, Saha PK, Peachey H, Snyder PJ
Source: J Bone Miner Res., 2008; 23(5): 730-40, PMID: 18251704
Keywords: MRI, bone structure, estrogen
GID: 1511; Last update: 09.09.2008

Research Studies (2006)

Comparison of the skeletal effects of the progestogens desogestrel and levonorgestrel in oral contraceptive preparations in young women: controlled, open, partly randomized investigation over 13 cycles

AIM: This 12-month study was conducted to evaluate the skeletal effects of two monophasic oral contraceptives containing 20 mug of ethinylestradiol and 100 mug of levonorgestrel (LEVO) or 150 mug of desogestrel weiter...

Author: Hartard M, Kleinmond C, Luppa P, Zelger O, Egger K, Wiseman M, Weissenbacher ER, Felsenberg D, Erben RG
Source: Contraception., 2006; 74(5): 367-75, PMID: 17046377
GID: 1516; Last update: 09.09.2008

Research Studies (2008)

Methods for measurement of pediatric bone

Many experts believe that optimizing bone mineral accrual early in life may prevent childhood fractures and possibly delay the development of osteoporosis later in life. Adequate nutrition and physical activity weiter...

Author: Binkley TL, Berry R, Specker BL
Source: Rev Endocr Metab Disord., 2008; 9(2): 95-106, PMID: 18247119
Keywords: Pediatrics . pQCT. DXA . Ultrasound . Bone density . Bone geometry, children
GID: 1508; Last update: 09.09.2008

Research Studies (2008)

Glucocorticoid excess affects cortical bone geometry in premenopausal, but not postmenopausal, women

Glucocorticoid (GC) excess causes a great increase in fracture risk, but the effects of GC excess on cortical bone geometry are unknown. The present study was performed to examine the effects of GC excess on co weiter...

Author: Kaji H, Yamauchi M, Chihara K, Sugimoto T
Source: Calcif Tissue Int., 2008; 82(3): 182-90, PMID: 18278571
Keywords: cortisone, bone geometry
GID: 1376; Last update: 22.07.2008

Research Studies (2008)

Whole body vibration in cystic fibrosis - a pilot study

Introduction: In cystic fibrosis (CF), bone mass deficits as well as a lack of muscle mass and force have been described. The bone mass deficits are thought to be at least in part secondary to the reduced muscl weiter...

Author: Roth J, Wust M, Rawer R, Schnabel D, Armbrecht G, Beller G, Rembitzki I, Wahn U, Felsenberg D, Staab D
Source: J Musculoskelet Neuronal Interact., 2008; 8(2): 179-87, PMID: 18622087
Keywords: Cystic Fibrosis, Whole Body Vibration, Bone, Muscle, Mechanography
#GRFS126
GID: 1382; Last update: 22.07.2008
More information: Original Article

Research Studies (2008)

Effects of Depot medroxyprogesterone acetate on bone density and bone metabolism before and after peak bone mass: a case-control study

INTRODUCTION: Depot medroxyprogesterone acetate (DMPA; Depo-Provera, Tadworth, UK) contraception is used by more than 9 million women worldwide and has a high usage among teenagers in the United Kingdom and the weiter...

Author: Walsh JS, Eastell R, Peel NF
Source: J Clin Endocrinol Metab., 2008; 93(4): 1317-23, PMID: 18230659
Keywords: Estrogen, hormones
GID: 1380; Last update: 22.07.2008

Research Studies (2008)

Relationship between endogenous parathyroid hormone and bone metabolism/geometry in female patients treated with glucocorticoid

Although the role of PTH (parathyroid hormone) has been debated in glucocorticoid (GC)-induced osteoporosis (GIO), clinical data about the relation of endogenous PTH to bone metabolism in patients treated with weiter...

Author: Kaji H, Yamauchi M, Chihara K, Sugimoto T
Source: Horm Metab Res., 2008; 40(1): 60-5, PMID: 18072075
Keywords: pth, cortisone, hormone
GID: 1377; Last update: 22.07.2008

Research Studies (2007)

Bone size normalizes with age in children and adolescents with type 1 diabetes

OBJECTIVE: The aim of this study was to establish whether type 1 diabetes has a long-term effect on bone development in children and adolescents. RESEARCH DESIGN AND METHODS: Bone characteristics and muscle cro weiter...

Author: Bechtold S, Putzker S, Bonfig W, Fuchs O, Dirlenbach I, Schwarz HP
Source: Diabetes Care., 2007; 30(8): 2046-50, PMID: 17456838
Keywords: children, adolescents, bone geometry, diabetes
GID: 1379; Last update: 22.07.2008

Fundamental Studies (2007)

Combined xeno/auto-grafting of a benign osteolytic lesion in a dog, using a novel bovine cancellous bone biomaterial

CASE HISTORY: A 4-year-old female Labrador Retriever was diagnosed with an osteolytic lesion of the right distal radius. CLINICAL FINDINGS: Radiographs indicated a well-circumscribed radiolucent area 18 x 15 x weiter...

Author: Worth AJ, Thompson KG, Owen MC, Mucalo MR, Firth EC
Source: N Z Vet J., 2007; 55(3): 143-8, PMID: 17534418
GID: 1401; Last update: 22.07.2008

Research Studies (2008)

High-volume FES-cycling partially reverses bone loss in people with chronic spinal cord injury

Spinal cord injury (SCI) leads to severe bone loss in the paralysed limbs and to a resulting increased fracture risk thereof. Since long bone fractures can lead to comorbidities and a reduction in quality of li weiter...

Author: Frotzler A, Coupaud S, Perret C, Kakebeeke TH, Hunt KJ, Donaldson Nde N, Eser P
Source: Bone., 2008; 43(1): 169-76, PMID: 18440891
GID: 1374; Last update: 22.07.2008

Research Studies (2008)

Trabecular structure quantified with the MRI-based virtual bone biopsy in postmenopausal women contributes to vertebral deformity burden independent of areal vertebral BMD

In postmenopausal women with a wide range of vertebral deformities, MRI-based structural measures of topology and scale at the distal radius are shown to account for as much as 30% of vertebral deformity, indep weiter...

Author: Ladinsky GA, Vasilic B, Popescu AM, Wald M, Zemel BS, Snyder PJ, Loh L, Song HK, Saha PK, Wright AC, Wehrli FW
Source: J Bone Miner Res., 2008; 23(1): 64-74, PMID: 17784842
GID: 1373; Last update: 22.07.2008

Research Studies (2008)

Peripheral quantitative computed tomography in children and adolescents: the 2007 ISCD Pediatric Official Positions

Peripheral quantitative computed tomography (pQCT) has mainly been used as a research tool in children. To evaluate the clinical utility of pQCT and formulate recommendations for its use in children, the Intern weiter...

Author: Zemel B, Bass S, Binkley T, Ducher G, Macdonald H, McKay H, Moyer-Mileur L, Shepherd J, Specker B, Ward K, Hans D
Source: J Clin Densitom., 2008; 11(1): 59-74, PMID: 18442753
GID: 1375; Last update: 22.07.2008

Research Studies (2008)

Decline of specific peak jumping power with age in master runners

Background: It is difficult to disentangle the effects of pure ageing from those of disuse. Master athletes, however, provide an opportunity to assess the effects of ageing per se, as these people maintain high weiter...

Author: Michaelis I, Kwiet A, Gast U, Boshof A, Antvorskov T, Jung T, Rittweger J, Felsenberg D
Source: J Musculoskelet Neuronal Interact., 2008; 8(1): 64-70, PMID: 18398267
Keywords: Power
GID: 1309; Last update: 05.05.2008
More information: Original Article

Research Studies (2007)

Tibial geometry is associated with failure load ex vivo: a MRI, pQCT and DXA study

SUMMARY: We studied the relations between bone geometry and density and the mechanical properties of human cadaveric tibiae. Bone geometry, assessed by MRI and pQCT, and bone density, assessed by DXA, were sign weiter...

Author: Liu D, Manske SL, Kontulainen SA, Tang C, Guy P, Oxland TR, McKay HA
Source: Osteoporos Int., 2007; 18(7): 991-7, PMID: 17268944
GID: 1267; Last update: 06.03.2008

Research Studies (2007)

Impaired geometric properties of tibia in older women with hip fracture history

SUMMARY: This study evaluated side-to-side differences in tibial mineral mass and geometry in women with previous hip fracture sustained on average 3.5 years earlier. Both tibial mineral mass and geometry were weiter...

Author: Mikkola T, Sipilä S, Portegijs E, Kallinen M, Alén M, Kiviranta I, Pekkonen M, Heinonen A
Source: Osteoporos Int., 2007; 18(8): 1083-90, PMID: 17323107
GID: 1264; Last update: 06.03.2008

Research Studies (2006)

Material matters: a mechanostat-based perspective on bone development in osteogenesis imperfecta and hypophosphatemic rickets

This perspective paper presents a hypothesis that links abnormalities of bone material with densitometric findings in two congenital metabolic bone disorders, osteogenesis imperfecta type I (OI) and X-linked hy weiter...

Author: Rauch F
Source: J Musculoskelet Neuronal Interact., 2006; 6(2): 142-6, PMID: 16849823
GID: 1261; Last update: 06.03.2008
More information: Original Article

Research Studies (2007)

Relationship of volumetric bone mineral density and structural parameters with ERalpha gene polymorphisms

Bone mineral density (BMD) contributes to bone strength, and methods for clinical assessment of bone quality characteristics beyond what can be gathered by BMD are awaited. Peripheral quantitative computed tomo weiter...

Author: Cepollaro C, Lauretani F, Gozzini A, Masi L, Falchetti A, Del Monte F, Carbonell-Sala S, Tanini A, Corsi AM, Bandinelli S, Ferrucci L, Brandi ML
Source: Calcif Tissue Int., 2007; 80(5): 307-15, PMID: 17505773
GID: 1259; Last update: 06.03.2008

Research Studies (2007)

Quantitative MRI of parallel changes of articular cartilage and underlying trabecular bone in degeneration

OBJECTIVE: To determine the interrelations between degenerative changes in articular cartilage and underlying trabecular bone during development of osteoarthritis and to test the ability of quantitative magneti weiter...

Author: Lammentausta E, Kiviranta P, Töyräs J, Hyttinen MM, Kiviranta I, Nieminen MT, Jurvelin JS
Source: Osteoarthritis Cartilage., 2007; 15(10): 1149-57, PMID: 17502160
GID: 1272; Last update: 06.03.2008

Research Studies (2006)

Leptin is a negative independent predictor of areal BMD and cortical bone size in young adult Swedish men

The association between leptin and areal BMD has been controversial, and the predictive role of leptin on cortical volumetric BMD and bone size has not previously been studied. We show that leptin is a negative weiter...

Author: Lorentzon M, Landin K, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2006; 21(12): 1871-8, PMID: 17002557
GID: 1252; Last update: 06.03.2008

Research Studies (2005)

Growth patterns at distal radius and tibial shaft in pubertal girls: a 2-year longitudinal study

Bone changes, in terms of both size and BMD, were assessed longitudinally in pubertal girls. Before puberty, BMD at the distal radius declined, whereas bone size increased, suggesting that normal growing girls weiter...

Author: Wang Q, Alén M, Nicholson P, Lyytikäinen A, Suuriniemi M, Helkala E, Suominen H, Cheng S
Source: J Bone Miner Res., 2005; 20(6): 954-61, PMID: 15883635
GID: 1248; Last update: 06.03.2008

Research Studies (2005)

Examining bone surfaces across puberty: a 20-month pQCT trial

This follow-up study assessed sex differences in cortical bone growth at the tibial midshaft across puberty. In both sexes, periosteal apposition dominated over endosteal resorption. Boys had a greater magnitud weiter...

Author: Kontulainen SA, Macdonald HM, Khan KM, McKay HA
Source: J Bone Miner Res., 2005; 20(7): 1202-7, PMID: 15940373
GID: 1249; Last update: 06.03.2008

Research Studies (2005)

Age of attainment of peak bone mass is site specific in Swedish men--The GOOD study

Results from this study suggest that PBM has been attained in the spine and femoral neck, but not in the radius or tibia, in 18- to 20-year-old men, in which an endosteal contraction and increase in cortical vo weiter...

Author: Lorentzon M, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2005; 20(7): 1223-7, PMID: 15940376
GID: 1250; Last update: 06.03.2008

Research Studies (2007)

Is a school-based physical activity intervention effective for increasing tibial bone strength in boys and girls

This 16-month randomized, controlled school-based study compared change in tibial bone strength between 281 boys and girls participating in a daily program of physical activity (Action Schools! BC) and 129 same weiter...

Author: Macdonald HM, Kontulainen SA, Khan KM, McKay HA
Source: J Bone Miner Res., 2007; 22(3): 434-46, PMID: 17181400
GID: 1253; Last update: 06.03.2008

Research Studies (2007)

Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y)

CONTEXT: Sex steroids are involved in the regulation of pubertal cortical bone expansion in males. In vitro studies have indicated that the enzyme uridine diphosphate glucuronosyltransferase (UGT) 2B7 has the c weiter...

Author: Swanson C, Lorentzon M, Vandenput L, Labrie F, Rane A, Jakobsson J, Chouinard S, Bélanger A, Ohlsson C
Source: J Clin Endocrinol Metab., 2007; 92(9): 3697-704, PMID: 17579197
GID: 1255; Last update: 06.03.2008

Research Studies (2007)

Genetic and environmental determinants of volumetric and areal BMD in multi-generational families of African ancestry: the Tobago Family Health Study

BMD is higher and fracture risk is lower among individuals of African versus European descent, but little is known about the genetic architecture of BMD in the former group. Heritabilities of areal and volumetr weiter...

Author: Wang X, Kammerer CM, Wheeler VW, Patrick AL, Bunker CH, Zmuda JM
Source: J Bone Miner Res., 2007; 22(4): 527-36, PMID: 17227221
GID: 1254; Last update: 06.03.2008

Research Studies (2007)

Age-related decline in trabecular and cortical density: a 5-year peripheral quantitative computed tomography follow-up study of pre- and postmenopausal women

This 5-year prospective study assessed changes in trabecular and cortical volumetric bone density at the non-weight-bearing radius and weight-bearing tibia among clinically healthy pre- and postmenopausal women weiter...

Author: Uusi-Rasi K, Sievänen H, Pasanen M, Kannus P
Source: Calcif Tissue Int., 2007; 81(4): 249-53, PMID: 17768589
GID: 1278; Last update: 06.03.2008

Research Studies (2006)

Determinants of bone mass and bone size in a large cohort of physically active young adult men

The determinants of bone mineral density (BMD) at multiple sites were examined in a fit college population. Subjects were 755 males (mean age = 18.7 years) entering the United States Military Academy. A questio weiter...

Author: Ruffing JA, Cosman F, Zion M, Tendy S, Garrett P, Lindsay R, Nieves JW
Source: Nutr Metab (Lond)., 2006; 3: 14, PMID: 16480509
GID: 1219; Last update: 05.03.2008
More information: Original Article

Research Studies (2006)

Bone loss from the human distal tibia epiphysis during 24 days of unilateral lower limb suspension

Bone loss during immobilization is well documented. Currently, the only means of studying this in human beings is bed rest, which is resource intensive and inconvenient for the subjects. Unilateral lower limb s weiter...

Author: Rittweger J, Winwood K, Seynnes O, de Boer M, Wilks D, Lea R, Rennie M, Narici M
Source: J Physiol., 2006; 577(Pt 1): 331-7, PMID: 17023509
GID: 1210; Last update: 05.03.2008

Research Studies (2006)

Muskel und Knochen - eine funktionelle Einheit

Einleitung: Im sich entwickelnden Organismus von Kindern und Jugendlichen steht die Kraft und die Masse der Muskulatur in biologischer Beziehung zur Geometrie und Masse des Skeletts. Methoden: Vor dem Hintergr weiter...

Author: E Schönau, O Fricke
Source: Dtsch Ärztebl 103: (2006) A3414 - 3418, 2006; 103: 3414-3418
GID: 1218; Last update: 05.03.2008

Research Studies (2007)

Skeletal effects of long-term estrogen and testosterone replacement treatment in a man with congenital aromatase deficiency: evidences of a priming effect of estrogen for sex steroids action on bone

The relative contribution of each sex steroid (i.e. estrogen and androgen) on bone in men and the relationships among sex steroids and changes in BMD and bone strength are still unknown. A defective BMD of bone weiter...

Author: Rochira V, Zirilli L, Madeo B, Aranda C, Caffagni G, Fabre B, Montangero VE, Roldan EJ, Maffei L, Carani C
Source: Bone., 2007; 40(6): 1662-8, PMID: 17400043
GID: 1224; Last update: 05.03.2008

Research Studies (2006)

Bone density comparison of selected carpal and tarsal bones: validation for their use in compression fracture fixation studies of scaphoid screws

INTRODUCTION: To determine if trabecular, total and cortical bone densities of the capitate, navicular, cuboid, and first cuneiform were equivalent to those of the scaphoid, such that these bones could be used weiter...

Author: Brutus JP, Rajkumar JS, Rust E, Harley BJ, Palmer AK, Werner FW
Source: Chir Main., 2006; 25(2): 77-80, PMID: 16841768
GID: 1226; Last update: 05.03.2008

Research Studies (2005)

The discriminative ability of peripheral and axial bone measurements to identify proximal femoral, vertebral, distal forearm and proximal humeral fractures: a case control study

Previous studies evaluating peripheral bone measurement devices have often used discontinued technologies, compared single devices, only evaluated a single fracture syndrome or failed to make a comparison with weiter...

Author: Clowes JA, Eastell R, Peel NF
Source: Osteoporos Int., 2005; 16(12): 1794-802, PMID: 15947861
GID: 1240; Last update: 05.03.2008

Research Studies (2003)

Bone density measurements in pediatric patients with renal osteodystrophy

Peripheral quantitative computed tomography (pQCT) can selectively measure the densities of cortical and trabecular bone, but there is limited information about its use in patients with renal osteodystrophy. Th weiter...

Author: Lima EM, Goodman WG, Kuizon BD, Gales B, Emerick A, Goldin J, Salusky IB
Source: Pediatr Nephrol., 2003; 18(6): 554-9, PMID: 12712376
GID: 1229; Last update: 05.03.2008

Research Studies (2005)

High and low density in the same bone: a study on children and adolescents with mild osteogenesis imperfecta

Children and adolescents with osteogenesis imperfecta (OI) generally have low bone mineral density (BMD) at the lumbar spine and hip. However, the effects of the disease on diaphyseal bone have not been well ch weiter...

Author: Rauch F, Land C, Cornibert S, Schoenau E, Glorieux FH
Source: Bone., 2005; 37(5): 634-41, PMID: 16112635
GID: 1228; Last update: 05.03.2008

Scientific Publications (2006)

Measurement of bone density and bone strength with pQCT

Author: J. Willnecker
Source: Novel approaches towards primate toxicology, 2006; 13 - 19
GID: 1213; Last update: 05.03.2008
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Research Studies (2007)

Bone loss and mechanical properties of tibia in spinal cord injured men

AIM: The effects of Spinal Cord Injury (SCI) on bone in paralyzed areas are well documented but there are few data for the importance of the level of injury in the decrease of mechanical strength in paralyzed l weiter...

Author: Dionyssiotis Y, Trovas G, Galanos A, Raptou P, Papaioannou N, Papagelopoulos P, Petropoulou K, Lyritis GP
Source: J Musculoskelet Neuronal Interact., 2007; 7(1): 62-8, PMID: 17396008
GID: 1217; Last update: 05.03.2008
More information: Original Article

Research Studies (2005)

Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial

BACKGROUND: Little is known about the relative effectiveness of calcium supplementation from food or pills with or without vitamin D supplementation for bone mass accrual during the rapid growth period. OBJECTI weiter...

Author: Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F
Source: Am J Clin Nutr., 2005; 82(5): 1115-26; quiz 1147-8, PMID: 16280447
GID: 1185; Last update: 04.03.2008

Research Studies (2006)

Accuracy of pQCT for evaluating the aged human radius: an ashing, histomorphometry and failure load investigation

INTRODUCTION: Quantifying the determinants of bone strength is essential to understanding if or how the structure will fail under load. Determining failure requires knowledge of material and geometric propertie weiter...

Author: Ashe MC, Khan KM, Kontulainen SA, Guy P, Liu D, Beck TJ, McKay HA
Source: Osteoporos Int., 2006; 17(8): 1241-51, PMID: 16683179
GID: 1188; Last update: 04.03.2008

Research Studies (2006)

Cortical pQCT measures are associated with fractures in dialysis patients

To determine if pQCT could identify HD patients with fractures, we conducted a cross-sectional study in 52 men and women on HD. We found that cortical, but not trabecular, pQCT measures were associated with fra weiter...

Author: Jamal SA, Gilbert J, Gordon C, Bauer DC
Source: J Bone Miner Res., 2006; 21(4): 543-8, PMID: 16598374
GID: 1191; Last update: 04.03.2008

Research Studies (2006)

Pubertal timing predicts previous fractures and BMD in young adult men: the GOOD study

The importance of pubertal timing for adult BMD in males was studied through association of pubertal timing with young adult bone phenotype. Pubertal timing was found to predict both cortical and trabecular vol weiter...

Author: Kindblom JM, Lorentzon M, Norjavaara E, Hellqvist A, Nilsson S, Mellström D, Ohlsson C
Source: J Bone Miner Res., 2006; 21(5): 790-5, PMID: 16734395
GID: 1189; Last update: 04.03.2008

Research Studies (2006)

Change in cortical bone density and its distribution differs between boys and girls during puberty

CONCEPT: Postmenarchal girls and premenopausal women have 3-4% higher cortical bone density (CoD, milligrams per cubic centimeter), compared with postpubertal boys and men, respectively. Females" denser cortica weiter...

Author: Kontulainen SA, Macdonald HM, McKay HA
Source: J Clin Endocrinol Metab., 2006; 91(7): 2555-61, PMID: 16636118
GID: 1192; Last update: 04.03.2008

Research Studies (2005)

The state of pediatric bone: summary of the ASBMR pediatric bone initiative

Author: Klein GL, Fitzpatrick LA, Langman CB, Beck TJ, Carpenter TO, Gilsanz V, Holm IA, Leonard MB, Specker BL, ASBMR Group
Source: J Bone Miner Res., 2005; 20(12): 2075-81, PMID: 16294260
GID: 1195; Last update: 04.03.2008

Research Studies (2005)

Effects of age, grip strength and smoking on forearm volumetric bone mineral density and bone geometry by peripheral quantitative computed tomography: comparisons between female and male

Peripheral quantitative computed tomography (pQCT) is useful to measure volumetric bone mineral density (vBMD) distinguishing trabecular from cortical bones as well as quantity of bone geometry. In the present weiter...

Author: Kaji H, Kosaka R, Yamauchi M, Kuno K, Chihara K, Sugimoto T
Source: Endocr J., 2005; 52(6): 659-66, PMID: 16410656
GID: 1203; Last update: 04.03.2008

Research Studies (2006)

Changes in bone mass and bone turnover following tibial shaft fracture

INTRODUCTION: Bone loss occurs in the regional bone following tibial shaft fracture. An earlier cross-sectional study showed that measurements made at the metaphyseal region of the tibia using peripheral quanti weiter...

Author: Veitch SW, Findlay SC, Hamer AJ, Blumsohn A, Eastell R, Ingle BM
Source: Osteoporos Int., 2006; 17(3): 364-72, PMID: 16362144
GID: 1199; Last update: 04.03.2008

Research Studies (2006)

A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency

CONTEXT: Low bone mass is a characteristic feature of the adult GH deficiency (GHD) syndrome, but recent dual-energy x-ray absorptiometry (DXA) studies in patients with GH-receptor and GHRH-receptor gene mutati weiter...

Author: Murray RD, Adams JE, Shalet SM
Source: J Clin Endocrinol Metab., 2006; 91(2): 432-8, PMID: 16278268
GID: 1197; Last update: 04.03.2008

Research Studies (2005)

Case-control study of the muscular compartments and osseous strength in neurofibromatosis type 1 using peripheral quantitative computed tomography

Skeletal anomalies are observed in neurofibromatosis type 1 (NF1), but the pathogenesis is unknown. Given that muscle mass is important in the development of the strength of bone, peripheral quantitative comput weiter...

Author: Stevenson DA, Moyer-Mileur LJ, Carey JC, Quick JL, Hoff CJ, Viskochil DH
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 145-9, PMID: 15951630
GID: 1163; Last update: 03.03.2008
More information: Original Article

Research Studies (2005)

Maturity- and sex-related changes in tibial bone geometry, strength and bone-muscle strength indices during growth: a 20-month pQCT study

During growth, bone strength is conferred through subtle adaptations in bone mass and geometry in response to muscle forces. Few studies have examined the changes in bone geometry, strength and the bone-muscle weiter...

Author: Macdonald HM, Kontulainen SA, Mackelvie-O"Brien KJ, Petit MA, Janssen P, Khan KM, McKay HA
Source: Bone., 2005; 36(6): 1003-11, PMID: 15823517
GID: 1175; Last update: 03.03.2008

Research Studies (2005)

Bone measurements by peripheral quantitative computed tomography (pQCT) in children with cerebral palsy

OBJECTIVE: To use peripheral quantitative computed tomography (pQCT) to determine bone measurements in patients with cerebral palsy (CP) age 3 to 20 years and compare them with control subjects. STUDY DESIGN: A weiter...

Author: Binkley T, Johnson J, Vogel L, Kecskemethy H, Henderson R, Specker B
Source: J Pediatr., 2005; 147(6): 791-6, PMID: 16356433
GID: 1182; Last update: 03.03.2008

Research Studies (2005)

A cybernetic approach to osteoporosis in anorexia nervosa

A group of 25 female individuals, who had been admitted to the University Hospital with the diagnosis of anorexia nervosa (AN) 3 to 10 years before, was seen for a follow-up visit in the hospital. These women g weiter...

Author: Fricke O, Tutlewski B, Stabrey A, Lehmkuhl G, Schöenau E
Source: J Musculoskelet Neuronal Interact., 2005; 5(2): 155-61, PMID: 15951632
GID: 1165; Last update: 03.03.2008
More information: Original Article

Research Studies (2005)

Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children

BACKGROUND: Protein and alkalizing minerals are increasingly described as playing a major role in influencing bone status, not only in the elderly but also in children and adolescents. OBJECTIVE: We examined wh weiter...

Author: Alexy U, Remer T, Manz F, Neu CM, Schoenau E
Source: Am J Clin Nutr., 2005; 82(5): 1107-14, PMID: 16280446
GID: 1181; Last update: 03.03.2008

Research Studies (2002)

Mechanical strength of the proximal femur as predicted from geometric and densitometric bone properties at the lower limb versus the distal radius

This experimental study compares geometric and densitometric properties of cortical and trabecular bone at the lower limb and the distal radius with those at the femoral neck, and evaluates their ability to pre weiter...

Author: Lochmüller EM, Groll O, Kuhn V, Eckstein F
Source: Bone., 2002; 30(1): 207-16, PMID: 11792587
GID: 1156; Last update: 29.02.2008

Professional Articles (2004)

Diagnostik der Osteoporose Knochendichte bestimmen reicht nicht

Die Festigkeit eines Knochens hängt von vielen Faktoren ab und sie ändert sich je nach Alter des Patienten, mechanischer Beanspruchung und systematischen Gegebenheiten wie dem Hormonspiegel. Daher muß man da weiter...

Author: P. Schneider
Source: Der Allgemeinarzt, 2004; 2/04: 112-119
GID: 1155; Last update: 29.02.2008

Research Studies (2004)

Increased periosteal circumference remains present 12 months after an exercise intervention in preschool children

We previously reported that calcium intake enhanced the leg bone response to physical activity of preschool children in a 12-month randomized trial of calcium supplementation and physical activity. To determine weiter...

Author: Specker B, Binkley T, Fahrenwald N
Source: Bone., 2004; 35(6): 1383-8, PMID: 15589220
GID: 1154; Last update: 29.02.2008

Professional Articles (2004)

Diagnostik im Umbruch

Auf dem zweiten interdisziplinären Forum "Knochen und Muskeln - Neue Welten" gab es neue Erkenntnisse über den Zusammenhang von Muskeln und Knochen, die noch weiter wissenschaftlich überprüft werden müssen weiter...

Author: D Felsenberg
Source: Mobiles Leben, 2004; 4/04: 14 - 15
GID: 1157; Last update: 29.02.2008

Research Studies (2004)

Three children with lower limb fractures and a mineralization defect: a novel bone fragility disorder

In this report, we describe three unrelated children with an apparently novel bone fragility disorder that is associated with an idiopathic mineralization defect. Recurrent lower limb fractures started with wei weiter...

Author: Munns CF, Rauch F, Travers R, Glorieux FH
Source: Bone., 2004; 35(5): 1023-8, PMID: 15542026
GID: 1161; Last update: 29.02.2008

Research Studies (2004)

Estimation of bone mineral density and architectural parameters of the distal radius in hemodialysis patients using peripheral quantitative computed tomography

We analyzed bone changes in a series of hemodialysis patients followed up for a maximum of 299 months by assessing bone mineral density (BMD) and architectural parameters of the distal radius using peripheral q weiter...

Author: Hasegawa K, Hasegawa Y, Nagano A
Source: J Biomech., 2004; 37(5): 751-6, PMID: 15047004
GID: 1144; Last update: 28.02.2008

Research Studies (2001)

Bone mineral density in children with primary hyperoxaluria type I

BACKGROUND: In primary hyperoxaluria type I (PH 1), hepatic overproduction of oxalate leads to its deposition in various organ systems including bone (oxalosis). To evaluate skeletal status non-invasively in PH weiter...

Author: Behnke B, Kemper MJ, Kruse HP, Müller-Wiefel DE
Source: Nephrol Dial Transplant., 2001; 16(11): 2236-9, PMID: 11682674
GID: 1145; Last update: 28.02.2008

Research Studies (2004)

Is muscle power output a key factor in the age-related decline in physical performance? A comparison of muscle cross section, chair-rising test and jumping power

Ageing compromises locomotor capacity and is associated with an increased risk of falls. Several lines of evidence indicate that both changes in muscle mass and performance are causative. Most studies, however, weiter...

Author: Runge M, Rittweger J, Russo CR, Schiessl H, Felsenberg D
Source: Clin Physiol Funct Imaging., 2004; 24(6): 335-40, PMID: 15522042
GID: 1148; Last update: 28.02.2008
More information: Original Article

Scientific Publications (2004)

The peak bone mass concept: is it still relevant

The peak bone mass concept implies that optimal skeletal development during childhood and adolescence will prevent fractures in late adulthood. This concept is based on the observation that areal bone density i weiter...

Author: Schönau E
Source: Pediatr Nephrol., 2004; 19(8): 825-31, PMID: 15197638
GID: 1138; Last update: 26.02.2008

Research Studies (2004)

The bone mass concept: problems in short stature

Bone densitometry is currently one of the mainstays in the evaluation of systemic bone diseases in adults and is also increasingly used to assess primary or secondary bone disorders in children and adolescents. weiter...

Author: Schoenau E, Land C, Stabrey A, Remer T, Kroke A
Source: Eur J Endocrinol., 2004; 151 Suppl 1: S87-91, PMID: 15339251
GID: 1137; Last update: 26.02.2008

Scientific Publications (2004)

From bone biology to bone analysis

Bone development is one of the key processes characterizing childhood and adolescence. Understanding this process is not only important for physicians treating pediatric bone disorders, but also for clinicians weiter...

Author: Schoenau E, Saggese G, Peter F, Baroncelli GI, Shaw NJ, Crabtree NJ, Zadik Z, Neu CM, Noordam C, Radetti G, Hochberg Z
Source: Horm Res., 2004; 61(6): 257-69, PMID: 14963367
GID: 1136; Last update: 26.02.2008

Research Studies (2004)

Interpretation of whole body dual energy X-ray absorptiometry measures in children: comparison with peripheral quantitative computed tomography

The assessment of bone health in children requires strategies to minimize the confounding effects of bone size on dual energy X-ray absorptiometry (DXA) areal bone mineral density (BMD) results. Cortical bone c weiter...

Author: Leonard MB, Shults J, Elliott DM, Stallings VA, Zemel BS
Source: Bone., 2004; 34(6): 1044-52, PMID: 15193552
GID: 1134; Last update: 26.02.2008

Research Studies (2004)

Accuracy and precision of peripheral quantitative computed tomography measurements at the tibial metaphysis

The ability of 29 peripheral quantitative computed tomography (pQCT) software analysis modes at defining cortical from trabecular bone at three tibial metaphyseal regions was evaluated using five cadaveric tibi weiter...

Author: Veitch SW, Findlay SC, Ingle BM, Ibbotson CJ, Barrington A, Hamer AJ, Eastell R
Source: J Clin Densitom., 2004; 7(2): 209-17, PMID: 15181265
GID: 1139; Last update: 26.02.2008

Research Studies (2004)

Analysis of the functional muscle-bone unit of the forearm in pediatric renal transplant recipients

BACKGROUND: Renal transplantation in children and adolescents is associated with various skeletal complications. The incidence of spontaneous fractures appears to be increased, but the reasons for this are not weiter...

Author: Rüth EM, Weber LT, Schoenau E, Wunsch R, Seibel MJ, Feneberg R, Mehls O, Tönshoff B
Source: Kidney Int., 2004; 66(4): 1694-706, PMID: 15458468
GID: 1140; Last update: 26.02.2008

Research Studies (2003)

Aging bone in men and women: beyond changes in bone mineral density

Using peripheral quantitative computed tomography (pQCT) we assessed trabecular and cortical bone density, mass and geometric distribution at the tibia level in 512 men and 693 women, age range 20-102 years, ra weiter...

Author: Russo CR, Lauretani F, Bandinelli S, Bartali B, Di Iorio A, Volpato S, Guralnik JM, Harris T, Ferrucci L
Source: Osteoporos Int., 2003; 14(7): 531-8, PMID: 12827220
GID: 1116; Last update: 25.02.2008

Research Studies (2002)

Volumetric and projective bone mineral density

Projectional bone mineral density measurement so far used extensively in radiogrammetry and single and dual source absorptiometry is confronted with a serious limitation for the accurate evaluation of true dens weiter...

Author: Fujita T
Source: J Musculoskelet Neuronal Interact., 2002; 2(4): 302-5, PMID: 15758420
GID: 1115; Last update: 25.02.2008
More information: Original Article

Professional Articles (2004)

Diagnostik der Osteoporose

Dioe Festigkeit eines Knochens hängt von vielen Faktoren ab und sie ändert sich je anch Alter der Patienten, mechanischer Beanspruchung und systematischer Gegebenheiten wie dem Hormonhaushalt. Daher muss man weiter...

Author: P. Schneider
Source: Allgemeinarzt, 2004;
GID: 1129; Last update: 25.02.2008

Research Studies (2004)

Relationship between the duration of paralysis and bone structure: a pQCT study of spinal cord injured individuals

The aim of the present study was to describe bone loss of the separate compartments of trabecular and cortical bone, as well as changes in bone geometry of a large number of spinal cord injured (SCI) individual weiter...

Author: Eser P, Frotzler A, Zehnder Y, Wick L, Knecht H, Denoth J, Schiessl H
Source: Bone., 2004; 34(5): 869-80, PMID: 15121019
GID: 1126; Last update: 25.02.2008

Research Studies (2003)

Hormone replacement therapy improves distal radius bone structure by endocortical mineral deposition

Hormone replacement therapy (HRT) produces a small increase in bone mineral density (BMD) when measured by dual energy X-ray absorptiometry (DXA). The corresponding decrease in fracture risk is more impressive, weiter...

Author: Muller ME, Webber CE, Adachi JD
Source: Can J Physiol Pharmacol., 2003; 81(10): 952-8, PMID: 14608412
GID: 1121; Last update: 25.02.2008

Research Studies (2008)

Peripheral quantitative computed tomography of the tibia: pediatric reference values.

Peripheral quantitative computed tomography (pQCT) has been used in a number of pediatric studies. Reference data for children are primarily limited to the radius. The purpose of this study was to establish nor weiter...

Author: Moyer-Mileur LJ, Quick JL, Murray MA
Source: J Clin Densitom, 2008; 11(2): 283-94, PMID: 18164637
Keywords: pädiatrie
GID: 1114; Last update: 23.02.2008

Scientific Publications (2002)

Osteoporosis a disease requiring treatment or a physiologic osteopenia state? WHO definition in opposition to Utah Paradigm?

Author: Frost HM, Schneider P, Schneider R
Source: Dtsch Med Wochenschr., 2002; 127(48): 2570-4, PMID: 12457328
GID: 1091; Last update: 07.02.2008
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Research Studies (2001)

Bone quality parameters of the distal radius as assessed by pQCT in normal and fractured women

The aim of this study was to test the ability of some indicators of different aspects of bone quality (assessed by peripheral quantitative computed tomography in the distal radius) to discriminate between fract weiter...

Author: Schneider P, Reiners C, Cointry GR, Capozza RF, Ferretti JL
Source: Osteoporos Int., 2001; 12(8): 639-46, PMID: 11580077
GID: 1089; Last update: 07.02.2008

Research Studies (2001)

Age, sex, and grip strength determine architectural bone parameters assessed by peripheral quantitative computed tomography (pQCT) at the human radius

The purpose of this study was to estimate the relation of some noninvasively derived mechanical characteristics of radial bone including architectural parameters for bone strength to grip strength and muscle cr weiter...

Author: Hasegawa Y, Schneider P, Reiners C
Source: J Biomech., 2001; 34(4): 497-503, PMID: 11266673
GID: 1090; Last update: 07.02.2008

Scientific Publications (1998)

Quantitative Bestimmung der Knochenmasse: heutiger Stand und Fallstricke der Methoden

Author: P Schneider, C Reiners
Source: Med Welt (1998) 49: 157 - 163, 1998; 49: 157-163
GID: 1088; Last update: 07.02.2008

Research Studies (2002)

Die Muskel-Knochen-Einheit im Kindes- und Jugendalter. Konsequenzen für Prävention und Klassifikation der Osteoporose

Author: E Schönau
Source: Extracta Orthopaedica, 2002; 11: 20-25
GID: 1087; Last update: 07.02.2008

Research Studies (2003)

Bone mass and density response to a 12-month trial of calcium and vitamin D supplement in preadolescent girls

BACKGROUND: Maximal bone acquisition in adolescent girls through dietary and lifestyle practices is advocated to prevent or minimize the development of osteoporosis and its associated complications in later lif weiter...

Author: Moyer-Mileur LJ, Xie B, Ball SD, Pratt T
Source: J Musculoskelet Neuronal Interact., 2003; 3(1): 63-70, PMID: 15758367
GID: 1086; Last update: 07.02.2008
More information: Original Article

Scientific Publications (2002)

Noninvasive Analysis of Bone Mass, Structure, and Strength

Author: JL Ferretti, GR Cointry, RF Capozza
Source: Orthopaedic Issues in Osteoporosis CRC Press, 2002; 145 - 167
GID: 1081; Last update: 07.02.2008

Research Studies (2003)

The value of peripheral quantitative computed tomography (pQCT) in the diagnosis of osteoporosis

AIM: To evaluate the accuracy of distal radial pQCT in discriminating between osteoporotic fracture and non fracture cases and its efficiency to predict fractures. METHODS: Densitometric data determined with an weiter...

Author: Niedhart C, Braun K, Graf Stenbock-Fermor N, Bours F, Schneider P, Zilkens KW, Niethard FU
Source: Z Orthop Ihre Grenzgeb., 2003; 141(2): 135-42, PMID: 12695948
GID: 1085; Last update: 07.02.2008

Scientific Publications (2002)

Osteopenias and Osteoporoses - Muscle Bone Interactions, Absorptiometry, Safety Factors, and Fracture Risk

Author: JL Ferretti, HM Frost
Source: CRC Press 2002 (202 - 217) Orthopaedic Issues in Osteoporosis CRC Press, 2002; 202 - 217
GID: 1083; Last update: 07.02.2008

Research Studies (2003)

Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis

Treatment with teriparatide (rDNA origin) injection [teriparatide, recombinant human parathyroid hormone (1-34) [rhPTH(1-34)]] reduces the risk of vertebral and nonvertebral fragility fractures and increases ca weiter...

Author: Zanchetta JR, Bogado CE, Ferretti JL, Wang O, Wilson MG, Sato M, Gaich GA, Dalsky GP, Myers SL
Source: J Bone Miner Res., 2003; 18(3): 539-43, PMID: 12619939
GID: 1080; Last update: 07.02.2008

Research Studies (2003)

Effect of alendronate and exercise on bone and physical performance of postmenopausal women: a randomized controlled trial

In this randomized, double-blind, placebo-controlled 12-month trial we evaluated effects of weight- bearing jumping exercise and oral alendronate, alone or in combination, on the mass and structure of bone, ris weiter...

Author: Uusi-Rasi K, Kannus P, Cheng S, Sievänen H, Pasanen M, Heinonen A, Nenonen A, Halleen J, Fuerst T, Genant H, Vuori I
Source: Bone., 2003; 33(1): 132-43, PMID: 12919708
GID: 1097; Last update: 07.02.2008

Scientific Publications (1998)

Peripheral Quantitative Computed Tomography

Author: P Schneider, C Reiners
Source: Bone Densitometry and Osteoporosis Springer, 1998; 349-363
GID: 1093; Last update: 07.02.2008

Research Studies (2001)

Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine

OBJECTIVE: To examine bone development in children and adolescents who have uncomplicated idiopathic epilepsy and had received monotherapy with carbamazepine or valproic acid for at least 1 year. METHODS: Thirt weiter...

Author: Rieger-Wettengl G, Tutlewski B, Stabrey A, Rauch F, Herkenrath P, Schauseil-Zipf U, Schoenau E
Source: Pediatrics., 2001; 108(6): E107, PMID: 11731634
GID: 1075; Last update: 01.02.2008

Research Studies (2000)

Analysis of muscle strength and bone structure in children with renal disease

Bone structure and muscular strength of 30 children with renal disease were investigated by peripheral computed tomography and grip strength. Sixteen children suffered from nephrotic syndrome (NS) and had previ weiter...

Author: Tenbrock K, Kruppa S, Mokov E, Querfeld U, Michalk D, Schoenau E
Source: Pediatr Nephrol., 2000; 14(7): 669-72, PMID: 10912540
GID: 1076; Last update: 01.02.2008

Research Studies (2002)

Influence of puberty on muscle development at the forearm

Despite its fundamental importance for physical development, the growth of the muscle system has received relatively little consideration. In this study, we analyzed the relationship between cross-sectional are weiter...

Author: Neu CM, Rauch F, Rittweger J, Manz F, Schoenau E
Source: Am J Physiol Endocrinol Metab., 2002; 283(1): E103-7, PMID: 12067849
GID: 1060; Last update: 30.01.2008

Research Studies (2001)

Cut-off values determined for vertebral fracture by peripheral quantitative computed tomography in Japanese women

In spite of the benefits of bone mass measurement by dual-energy X-ray absorptiometry (DXA), the use of DXA has limitations. It is unable to assess a true bone density, and cannot discriminate between the trabe weiter...

Author: Gorai I, Nonaka K, Kishimoto H, Sakata H, Fujii Y, Fujita T
Source: Osteoporos Int., 2001; 12(9): 741-8, PMID: 11605740
GID: 1059; Last update: 30.01.2008

Research Studies (2001)

Musculoskeletal analyses of the forearm in young women with Turner syndrome: a study using peripheral quantitative computed tomography

Turner syndrome (TS) is associated with multiple skeletal abnormalities. Fracture incidence appears to be increased, but the reasons for this are not entirely clear. In the present study, we used peripheral qua weiter...

Author: Bechtold S, Rauch F, Noelle V, Donhauser S, Neu CM, Schoenau E, Schwarz HP
Source: J Clin Endocrinol Metab., 2001; 86(12): 5819-23, PMID: 11739445
GID: 1057; Last update: 30.01.2008

Professional Articles (2002)

Klinische Diagnostik des Regelkreises Muskel-Knochen am Unterschenkel

Die Entstehung von osteoporose-bezogenen Frakturen kann nicht allein aus Knochenparametern abgeleitet werden, denn extravertebrale Frakturen entstehen zu mehr als 90% durch einen Sturz. Erst die altersspezifisc weiter...

Author: M. Runge, H. Schießl, J. Rittweger
Source: Osteologie, 2002; 11(1): 25-37
GID: 1054; Last update: 30.01.2008
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Research Studies (2002)

Gender-specific pubertal changes in volumetric cortical bone mineral density at the proximal radius

It is well established that puberty affects the geometry of cortical bone differently in females and males. In the present study we investigated whether there are also gender differences in the volumetric bone weiter...

Author: Schoenau E, Neu CM, Rauch F, Manz F
Source: Bone., 2002; 31(1): 110-3, PMID: 12110422
GID: 1055; Last update: 30.01.2008

Research Studies (2002)

Bone mineral content per muscle cross-sectional area as an index of the functional muscle-bone unit

Bone densitometric data often are difficult to interpret in children and adolescents because of large inter- and intraindividual variations in bone size. Here, we propose a functional approach to bone densitome weiter...

Author: Schoenau E, Neu CM, Beck B, Manz F, Rauch F
Source: J Bone Miner Res., 2002; 17(6): 1095-101, PMID: 12054165
GID: 1053; Last update: 30.01.2008

Scientific Publications (2000)

The "muscle-bone unit" in children and adolescents: a 2000 overview

In former views hormones, calcium, vitamin D and other humoral and nonmechanical agents dominated control of postnatal bone strength (and "mass") in children and adolescents. However later evidence that led to weiter...

Author: Frost HM, Schönau E
Source: J Pediatr Endocrinol Metab., 2000; 13(6): 571-90, PMID: 10905381
GID: 1027; Last update: 29.01.2008

Research Studies (1998)

Problems of bone analysis in childhood and adolescence

The monitoring of bone metabolism and skeletal development during childhood and adolescence is becoming increasingly important in the prevention of osteoporosis. This is especially important in patients with ch weiter...

Author: Schönau E
Source: Pediatr Nephrol., 1998; 12(5): 420-9, PMID: 9686965
GID: 1008; Last update: 29.01.2008

Research Studies (1998)

The development of the skeletal system in children and the influence of muscular strength

In a study on 14 healthy children aged from 6 to 13 years, the volumetric spongiosa bone density (SBD), cortical bone density (CBD), bone cross-sectional area (BCSA), cortical area (CA), and bone strength index weiter...

Author: Schönau E
Source: Horm Res., 1998; 49(1): 27-31, PMID: 9438782
GID: 1007; Last update: 29.01.2008

Research Studies (2001)

The development of bone strength at the proximal radius during childhood and adolescence

Current investigations of bone development mostly focus on bone mass, but bone strength may be functionally more important than mass. Therefore, we compared the developmental changes in cortical bone mass (BMCc weiter...

Author: Schoenau E, Neu CM, Rauch F, Manz F
Source: J Clin Endocrinol Metab., 2001; 86(2): 613-8, PMID: 11158018
GID: 1036; Last update: 29.01.2008

Research Studies (2000)

Association of the vitamin D receptor genotype BB with low bone density in hyperthyroidism

Bone mineral density (BMD) is modulated by genetic and environmental factors or certain diseases. In several conditions such as low calcium intake, an influence of vitamin D receptor (VDR) polymorphisms on BMD weiter...

Author: Obermayer-Pietsch BM, Frühauf GE, Chararas K, Mikhail-Reinisch S, Renner W, Berghold A, Kenner L, Lackner C
Source: J Bone Miner Res., 2000; 15(10): 1950-5, PMID: 11028447
GID: 1039; Last update: 29.01.2008

Research Studies (1998)

On new opportunities for absorptiometry

Mechanical loads cause bone strains; and muscle forces, not body weight, cause the largest strains. The strains help to control the effects of bone modeling and remodeling on bone strength and "mass." When stra weiter...

Author: Ferretti JL, Schiessl H, Frost HM
Source: J Clin Densitom., 1998; 1(1): 41-53, PMID: 15304912
GID: 1024; Last update: 29.01.2008

Research Studies (2000)

Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players

Bilateral bone characteristics of the humerus (proximal, shaft, and distal sites) and radius (shaft and distal sites) in 12 former Finnish national-level male tennis players (mean age 30 years) and their 12 age weiter...

Author: Haapasalo H, Kontulainen S, Sievänen H, Kannus P, Järvinen M, Vuori I
Source: Bone., 2000; 27(3): 351-7, PMID: 10962345
GID: 1028; Last update: 29.01.2008

Research Studies (1998)

Peripheral quantitative computed tomography in human long bones: evaluation of in vitro and in vivo precision

Despite the excellent performance in clinical practice and research, the dual-energy X-ray absorptiometry is restricted by the inherent planar nature of the measurement and the inability to discriminate between weiter...

Author: Sievänen H, Koskue V, Rauhio A, Kannus P, Heinonen A, Vuori I
Source: J Bone Miner Res., 1998; 13(5): 871-82, PMID: 9610752
GID: 1005; Last update: 29.01.2008

Research Studies (1999)

Alendronate increases bone density and bone strength at the distal radius in postmenopausal women

In addition to the alendronate Osteoporosis Intervention Trial (FOSIT) core protocol 901-0A of 1908 enrolled patients, the use of peripheral quantitative computed tomography (pQCT) was explored for the assessme weiter...

Author: Schneider PF, Fischer M, Allolio B, Felsenberg D, Schröder U, Semler J, Ittner JR
Source: J Bone Miner Res., 1999; 14(8): 1387-93, PMID: 10457271
GID: 1010; Last update: 29.01.2008

Research Studies (1999)

Peripheral quantitative computed tomography of the femoral neck in 60 Japanese women

Peripheral quantitative computed tomography (pQCT) is able to evaluate trabecular and cortical bone separately, and to determine geometric properties from cross-sectional images for noninvasive assessments of m weiter...

Author: Horikoshi T, Endo N, Uchiyama T, Tanizawa T, Takahashi HE
Source: Calcif Tissue Int., 1999; 65(6): 447-53, PMID: 10594163
GID: 1019; Last update: 29.01.2008

Scientific Publications (1997)

New Noninvasive pQCT Devices to Determine Bone Structure

Author: G Tysarczyk-Niemeyer
Source: J Jpn Soc Bone Morphom, 1997; 7: 97-105
GID: 1000; Last update: 29.01.2008

Research Studies (1999)

Perspectives on bone mechanical properties and adaptive response to mechanical challenge

The bones of the human skeleton serve a mechanical function besides providing a reservoir for calcium and hematopoietic homeostatis. When mechanically challenged, they usually respond and adapt; failure to do s weiter...

Author: Jiang Y, Zhao J, Rosen C, Geusens P, Genant HK
Source: J Clin Densitom., 1999; 2(4): 423-33, PMID: 10677796
GID: 1023; Last update: 29.01.2008

Research Studies (1998)

Estrogen and bone-muscle strength and mass relationships

The largest voluntary loads on bones come from muscles. To adapt bone strength and mass to them, special strain threshold ranges determine where modeling adds and strengthens bone, and where remodeling conserve weiter...

Author: Schiessl H, Frost HM, Jee WS
Source: Bone., 1998; 22(1): 1-6, PMID: 9437507
GID: 998; Last update: 29.01.2008

Research Studies (1998)

Clinical evaluation of a high-resolution new peripheral quantitative computerized tomography (pQCT) scanner for the bone densitometry at the lower limbs

Precision, long-term stability, linearity and accuracy of the x-ray peripheral quantitative computerized tomographic (pQCT) bone scanner XCT 3000 (Norland-Stratec Medical Sys.) were evaluated using the European weiter...

Author: Braun MJ, Meta MD, Schneider P, Reiners C
Source: Phys Med Biol., 1998; 43(8): 2279-94, PMID: 9725604
GID: 1006; Last update: 29.01.2008

Research Studies (1997)

Peripheral QCT for the diagnosis of osteoporosis

Author: Ito M, Tsurusaki K, Hayashi K
Source: Osteoporos Int., 1997; 7 Suppl 3: S120-7, PMID: 9536317
GID: 1001; Last update: 29.01.2008

Research Studies (2000)

pQCT measurement of bone parameters in young children: validation of technique

Dual-energy X-ray absorptiometry (DXA) measures areal bone mineral density (BMD) and is affected by bone size. Peripheral quantitative computed tomography (pQCT) measures volumetric density and should not be af weiter...

Author: Binkley TL, Specker BL
Source: J Clin Densitom., 2000; 3(1): 9-14, PMID: 10745298
GID: 1042; Last update: 29.01.2008

Research Studies (2000)

Estimation of the architectural properties of cortical bone using peripheral quantitative computed tomography

We assessed the volumetric bone mineral density (vBMD) and cross-sectional architecture of cortical bone at the distal radius by peripheral quantitative computed tomography (pQCT). The volumetric bone mineral d weiter...

Author: Hasegawa Y, Schneider P, Reiners C, Kushida K, Yamazaki K, Hasegawa K, Nagano A
Source: Osteoporos Int., 2000; 11(1): 36-42, PMID: 10663357
GID: 1045; Last update: 29.01.2008

Research Studies (2001)

Comparison of bone parameters by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography in Hutterite vs. non-Hutterite women aged 35-60 years

A previous report of elevated dual-energy X-ray absorptiometry (DXA) bone mineral density (BMD) Z scores suggests that Hutterite females might be significantly less likely to develop osteoporosis compared with weiter...

Author: Wosje KS, Binkley TL, Specker BL
Source: Bone., 2001; 29(2): 192-7, PMID: 11502483
GID: 1046; Last update: 29.01.2008

Research Studies (1997)

Noninvasive Assessment of Bone Architecture and Biomechanical Properties in Animals and Humans Employing pQCT Technology

Author: J L Ferretti
Source: J Jpn Soc Bone Morphom, 1997; 7: 115-125
GID: 999; Last update: 29.01.2008

Research Studies (2000)

Densitometric and tomographic analyses of musculoskeletal interactions in humans

Previous studies with standard densitometry (DXA) have suggested that the bone mass is strongly dependent on the muscle mass in the species, following a similar relationship at any age and sex hormones or relat weiter...

Author: Ferretti JL, Capozza RF, Cointry GR, Capiglioni R, Roldan EJ, Zanchetta JR
Source: J Musculoskelet Neuronal Interact., 2000; 1(1): 31-4, PMID: 15758522
GID: 1031; Last update: 29.01.2008
More information: Original Article

Research Studies (1996)

Measurement of radial bone mineral density and cortical thickness in children by peripheral quantitative computed tomography

Author: De Schepper, De Boeck & O. Louis
Source: Paediatric osteology, 1996; 135-140
GID: 986; Last update: 24.01.2008

Research Studies (1996)

Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell

Quantitative bone assessment today is primarily based on the analysis of bone mineral density (BMD). The geometric properties of bone, which are an important parameter for skeletal strength, are generally not c weiter...

Author: Augat P, Reeb H, Claes LE
Source: J Bone Miner Res., 1996; 11(9): 1356-63, PMID: 8864911
GID: 984; Last update: 24.01.2008

Research Studies (1996)

Bone and muscle development during childhood in health and disease

Author: E. Schönau, E. Werhahn, U. Schiedermaier, E. Mokov, K. Scheidhauer, E. Rietschel, F. Haverkamp, H. Schießl & D. Michalk
Source: Paediatric osteology, 1996; 1996
GID: 987; Last update: 24.01.2008

Research Studies (1995)

Knochenmineralgehalt bei Kindern und Jugendlichen mit Hyperkalziurie

Author: B. Lettgen, P. Rasche Ch. Reiners
Source: Monatssch. Kinderheilkunde, 1995; 143: 46-49
GID: 973; Last update: 24.01.2008

Scientific Publications (1992)

Stellenwert zweier unterschiedlicher Knochendichtemeßmethoden zur Bestimmung des Mineralgehalts am peripheren und axialen Skelett

(English) Between May 1990 and February 1991 we enrolled 212 patients of 410 referred to our clinic for bone mass evaluation according to different diagnosis or therapeutic procedures. These patients were divi weiter...

Author: P. Schneider, W. Börner, J. Rendl, C. Eilles, K. Schlißke, M. Scheubeck
Source: Z Orthop (1992) 130: 16-21, 1992; 130: 16-21
GID: 975; Last update: 24.01.2008

Scientific Publications (1990)

Ability of peripheral QCT at the radius in comparison to DEXA of the spine to diagnose osteoporosis in postmenopausal women

Author: P.Schneider, W. Börner
Source: Osteoporosis, 1990; 59: 921-924
GID: 974; Last update: 24.01.2008
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Research Studies (1995)

Bone mineral density in children and adolescents with juvenile diabetes: selective measurement of bone mineral density of trabecular and cortical bone using peripheral quantitative computed tomography

Bone mineral density (BMD) was studied in 21 children and adolescents with type I diabetes and in age- and sex-matched healthy controls. BMD was selectively measured in trabecular and total bone using periphera weiter...

Author: Lettgen B, Hauffa B, Möhlmann C, Jeken C, Reiners C
Source: Horm Res., 1995; 43(5): 173-5, PMID: 7782045
GID: 977; Last update: 24.01.2008

Research Studies (1996)

Knochendichte bei Kindern und Jugendlichen mit rheumatischen Erkrankungen. Vorläufige Ergebnisse einer Selektiven Messung von Spongiosa und Kortikalis mittels peripherer Computertomographie

(english) Selective measurements of bone mineral density (BMD) of trabecular and cortical bone at the ultradistal radius were made in 27 children with rheumatic diseases and in age- and sex-matched healthy con weiter...

Author: Lettgen B, Neudorf U, Hosse R, Peters S, Reiners C
Source: Klin Pädiatr, 1996; 208: 117-117
GID: 981; Last update: 24.01.2008

Research Studies (1995)

Multicenter German reference data base for peripheral quantitative computer tomography

The wide spread use of bone densitometers in Germany and other European countries has required the establishment of a validated reference population data base. A semianthropomorphic forearm cross-calibration ph weiter...

Author: Schneider P, Butz S, Allolio B, Börner W, Klein K, Lehmann R, Petermann K, Tysarczyk-Niemeyer G, Wüster C, Zander C, , et al
Source: Technol Health Care., 1995; 3(2): 69-73, PMID: 8574764
GID: 979; Last update: 24.01.2008

Research Studies (1996)

Noninvasive bone strength index as analysed by peripheral quantitative computed tomography

Author: H. Schießl, J.L.Ferretti, G. Tysarczyk-Niemeyer & J. Willnecker
Source: Paediatric Osteology, 1996; 141-145
GID: 982; Last update: 24.01.2008

Research Studies (1996)

Cortical and total bone mineral content of the radius: accuracy of peripheral computed tomography

The aim of the study was to evaluate the accuracy of an XCT 960 Stratec peripheral quantitative computed tomography (pQCT) device in assessing bone mineral content of the radius. We scanned 27 left forearm spec weiter...

Author: Louis O, Soykens S, Willnecker J, Van den Winkel P, Osteaux M
Source: Bone., 1996; 18(5): 467-72, PMID: 8739905
GID: 983; Last update: 24.01.2008

Research Studies (1997)

Quantitative computed tomography at the axial and peripheral skeleto

Author: Guglielmi G, Schneider P, Lang TF, Giannatempo GM, Cammisa M, Genant HK
Source: Eur Radiol., 1997; 7(10): 32-42, PMID: 9042764
GID: 989; Last update: 24.01.2008

Research Studies (1996)

Peripheral quantitative computed tomography: reference data and clinical experiences in chronic diseases

Author: Bernhard Lettgen
Source: Paediatric Osteology, 1996; 123-133
GID: 985; Last update: 24.01.2008

Research Studies (2003)

Änderung der Kraft und Stellenwert verschiedener Kraftmessmethoden bei älteren Frauen

Problemstellung: Der Verlust an Muskelkraft und -leistung ist bedeutsamer Risikofaktor für das erhöhte Sturz und Frakturrisiko im Alter. Die Erfassung der Muskelkraft/-leistung und des Muskelstatus spielt d weiter...

Author: Lammel C, Siegrist M, Zelger O, Jeschke D
Source: D. Zeitschrift Sportmed., Po-059, 2003; 54(7/8): 67
Keywords: elderly force
GID: 577; Last update: 02.01.2008

Fundamental Studies (2000)

Modulation of Strain Sensing: A New Approach for the Treatment of Osteoporosis

Author: Gasser JA
Source: J Musculoskelet Neuronal Interact., 2000; 2: 105-110
GID: 490; Last update: 10.12.2007
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Research Studies (2002)

Bone-Strength-Index for the description of setpoint changes of bone remodeling

Author: Hartard M, Schiessl H, Arians A, Jeschke D
Source: Int J Sports Med, 2002; 23 Suppl. 2: 154
Keywords: HRT
GID: 457; Last update: 06.12.2007

Research Studies (2000)

Correlation of Strength Strain Index (SSI) and Torque in Upper Limbs

Author: Hartard M, Horn D, Bartenstein P, Schießl H
Source: 2000;
GID: 358; Last update: 04.12.2007
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Research Studies (2003)

Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia

Sarcopenia, the reduction of muscle mass and strength that occurs with aging, is widely considered one of the major causes of disability in older persons. Surprisingly, criteria that may help a clinician to ide weiter...

Author: Lauretani F, Russo CR, Bandinelli S, Bartali B, Cavazzini C, Di Iorio A, Corsi AM, Rantanen T, Guralnik JM, Ferrucci L
Source: J Appl Physiol., 2003; 95(5): 1851-60, PMID: 14555665
GID: 1755; Last update: 02.12.2007

Research Studies (2006)

Mechanography--a new device for the assessment of muscle function in pediatrics

The development of the musculoskeletal system in children and adolescents became an important topic in the field of pediatric research when the connections between muscle force and bone diseases were revealed. weiter...

Author: Fricke O, Weidler J, Tutlewski B, Schoenau E
Source: Pediatr Res., 2006; 59(1): 46-9, PMID: 16327004
Keywords: Mechanography
GID: 304; Last update: 02.12.2007

Research Studies (2006)

Determinants of musculoskeletal frailty and the risk of falls in old age

Neuromuscular parameters that describe locomotion are indispensable variables for the diagnosis and treatment of frailty, fall risk and osteoporosis. A scientifically-based standardized locomotor assessment sho weiter...

Author: Runge M, Hunter G
Source: J Musculoskelet Neuronal Interact., 2006; 6(2): 167-73, PMID: 16849828
Keywords: Mechanography
GID: 303; Last update: 02.12.2007
More information: Original Article

Research Studies (2004)

Reproducibility of the jumping mechanography as a test of mechanical power output in physically competent adult and elderly subjects

OBJECTIVES: To compare the reproducibility of the newly developed jumping mechanography with other physical tests. DESIGN: Study 1: Repeated testing with an interval of 2 weeks to assess the short-term repetiti weiter...

Author: Rittweger J, Schiessl H, Felsenberg D, Runge M
Source: J Am Geriatr Soc., 2004; 52(1): 128-31, PMID: 14687327
Keywords: Mechanography
GID: 270; Last update: 02.12.2007

Professional Articles (2006)

Lokomotorisches Assessment / Locomotor Assessment

Einschränkungen der Fortbewegung sind die pathogenetische Endstrecke des Alterungsprozesses und vieler Erkrankungen. Die quantifizierende Messung von Bewegung gehört deshalb unverzichtbar zu einer medizinisch weiter...

Author: Runge M (Artikel aus 2006)
Source: arthritis + rheuma, 2006; 26/4: 217-224
GID: 56; Last update: 02.12.2007

Scientific Publications (2003)

Die Muskeln als Determinate des erfolgreichen Alterns

Author: Runge M
Source: MedReport, 2003; 13: 12-13
GID: 254; Last update: 01.12.2007

Scientific Publications (2000)

Neue Erkenntnisse über den Zusammenhang zwischen Knochenstabilität und Muskelkraft

Author: Schiessl H, Willnecker J
Source: TraumaLinc, 2000; 1:
Keywords: Mechanostat, Muscle-Bone Unit
GID: 190; Last update: 01.12.2007
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Fundamental Studies (2006)

Effect of primary hyperparathyroidism on volumetric bone mineral density and bone geometry assessed by peripheral quantitative computed tomography in postmenopausal women

CONTEXT: Primary hyperparathyroidism (PH) is characterized by inappropriate PTH elevation with or without hypercalcemia. Bone disease involves catabolic action at cortical sites, whereas cancellous sites and ge weiter...

Author: Charopoulos I, Tournis S, Trovas G, Raptou P, Kaldrymides P, Skarandavos G, Katsalira K, Lyritis GP
Source: J Clin Endocrinol Metab, 2006; 91(5): 1748-53, PMID: 16492695
GID: 24; Last update: 24.11.2007

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